Drugs related to monoamine oxidase activity.
Article Details
- CitationCopy to clipboard
Fisar Z
Drugs related to monoamine oxidase activity.
Prog Neuropsychopharmacol Biol Psychiatry. 2016 Aug 1;69:112-24. doi: 10.1016/j.pnpbp.2016.02.012. Epub 2016 Mar 2.
- PubMed ID
- 26944656 [ View in PubMed]
- Abstract
Progress in understanding the role of monoamine neurotransmission in pathophysiology of neuropsychiatric disorders was made after the discovery of the mechanisms of action of psychoactive drugs, including monoamine oxidase (MAO) inhibitors. The increase in monoamine neurotransmitter availability, decrease in hydrogen peroxide production, and neuroprotective effects evoked by MAO inhibitors represent an important approach in the development of new drugs for the treatment of mental disorders and neurodegenerative diseases. New drugs are synthesized by acting as multitarget-directed ligands, with MAO, acetylcholinesterase, and iron chelation as targets. Basic information is summarized in this paper about the drug-induced regulation of monoaminergic systems in the brain, with a focus on MAO inhibition. Desirable effects of MAO inhibition include increased availability of monoamine neurotransmitters, decreased oxidative stress, decreased formation of neurotoxins, induction of pro-survival genes and antiapoptotic factors, and improved mitochondrial functions.
DrugBank Data that Cites this Article
- Drugs
- Drug Interactions
Drugs Interaction Integrate drug-drug
interactions in your softwareEscitalopramLinezolid The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Escitalopram. EscitalopramFurazolidone The risk or severity of serotonin syndrome can be increased when Furazolidone is combined with Escitalopram. EscitalopramProcaine The risk or severity of serotonin syndrome can be increased when Procaine is combined with Escitalopram. EscitalopramProcarbazine The risk or severity of serotonin syndrome can be increased when Procarbazine is combined with Escitalopram. EscitalopramRasagiline The risk or severity of serotonin syndrome can be increased when Rasagiline is combined with Escitalopram.