Magnesium metabolism and its disorders.
Article Details
- CitationCopy to clipboard
Swaminathan R
Magnesium metabolism and its disorders.
Clin Biochem Rev. 2003 May;24(2):47-66.
- PubMed ID
- 18568054 [ View in PubMed]
- Abstract
Magnesium is the fourth most abundant cation in the body and plays an important physiological role in many of its functions. Magnesium balance is maintained by renal regulation of magnesium reabsorption. The exact mechanism of the renal regulation is not fully understood. Magnesium deficiency is a common problem in hospital patients, with a prevalence of about 10%. There are no readily available and easy methods to assess magnesium status. Serum magnesium and the magnesium tolerance test are the most widely used. Measurement of ionised magnesium may become more widely available with the availability of ion selective electrodes. Magnesium deficiency and hypomagnesaemia can result from a variety of causes including gastrointestinal and renal losses. Magnesium deficiency can cause a wide variety of features including hypocalcaemia, hypokalaemia and cardiac and neurological manifestations. Chronic low magnesium state has been associated with a number of chronic diseases including diabetes, hypertension, coronary heart disease, and osteoporosis. The use of magnesium as a therapeutic agent in asthma, myocardial infarction, and pre-eclampsia is also discussed. Hypermagnesaemia is less frequent than hypomagnesaemia and results from failure of excretion or increased intake. Hypermagnesaemia can lead to hypotension and other cardiovascular effects as well as neuromuscular manifestations. Causes and management of hypermagnesaemia are discussed.
DrugBank Data that Cites this Article
- Drugs
- Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Magnesium gluconate 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 Protein Humans NoInducerDetails Magnesium gluconate Adenylate cyclase type 1 Protein Humans NoSubstrateDetails Magnesium gluconate ATP synthase subunit delta, mitochondrial Protein Humans NoSubstrateDetails Magnesium gluconate Creatine kinase B-type Protein Humans NoSubstrateInducerDetails Magnesium gluconate Guanylate cyclase soluble subunit alpha-2 Protein Humans NoSubstrateDetails Magnesium gluconate Sodium/potassium-transporting ATPase subunit alpha-1 Protein Humans NoInducerDetails Magnesium gluconate Tyrosine-protein kinase ABL1 Protein Humans NoSubstrateInducerDetails - Drug Carriers
Drug Carrier Kind Organism Pharmacological Action Actions Magnesium Serum albumin Protein Humans UnknownNot Available Details - Drug Interactions
Drugs Interaction Integrate drug-drug
interactions in your softwareMagnesiumTetracycline The serum concentration of Magnesium can be decreased when it is combined with Tetracycline. MagnesiumMinocycline The serum concentration of Magnesium can be decreased when it is combined with Minocycline. MagnesiumAmiodarone The serum concentration of Magnesium can be decreased when it is combined with Amiodarone. MagnesiumPhenytoin The serum concentration of Magnesium can be decreased when it is combined with Phenytoin. MagnesiumPhenobarbital The serum concentration of Magnesium can be decreased when it is combined with Phenobarbital.