Drug interactions of clinical importance among the opioids, methadone and buprenorphine, and other frequently prescribed medications: a review.

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McCance-Katz EF, Sullivan LE, Nallani S

Drug interactions of clinical importance among the opioids, methadone and buprenorphine, and other frequently prescribed medications: a review.

Am J Addict. 2010 Jan-Feb;19(1):4-16. doi: 10.1111/j.1521-0391.2009.00005.x.

PubMed ID
20132117 [ View in PubMed
]
Abstract

Drug interactions are a leading cause of morbidity and mortality. Methadone and buprenorphine are frequently prescribed for the treatment of opioid addiction. Patients needing treatment with these medications often have co-occurring medical and mental illnesses that require medication treatment. The abuse of illicit substances is also common in opioid-addicted individuals. These clinical realities place patients being treated with methadone and buprenorphine at risk for potentially toxic drug interactions. A substantial literature has accumulated on drug interactions between either methadone or buprenorphine with other medications when ingested concomitantly by humans. This review summarizes current literature in this area.

DrugBank Data that Cites this Article

Drug Enzymes
DrugEnzymeKindOrganismPharmacological ActionActions
BuprenorphineCytochrome P450 3A4ProteinHumans
Unknown
Substrate
Inhibitor
Details
Drug Interactions
DrugsInteraction
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interactions in your software
Alfentanil
Phendimetrazine		Phendimetrazine may increase the analgesic activities of Alfentanil.
Alfentanil
Pseudoephedrine		Pseudoephedrine may increase the analgesic activities of Alfentanil.
Alfentanil
Diethylpropion		Diethylpropion may increase the analgesic activities of Alfentanil.
Alfentanil
Mephentermine		Mephentermine may increase the analgesic activities of Alfentanil.
Alfentanil
MMDA		MMDA may increase the analgesic activities of Alfentanil.