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Showing drug card for Methocarbamol (DB00423)

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Version 2.5
Creation Date 2005-06-13 13:24:05
Update Date 2009-06-23 18:05:55
Primary Accession Number DB00423
Secondary Accession Number
  • APRD01102
Name Methocarbamol
Drug Type
  • Approved
  • Small Molecule
Description A centrally acting muscle relaxant whose mode of action has not been established. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1206)
Synonyms Not Available
Brand Names
  1. AHR 85
  2. Avetil
  3. Delaxin
  4. Etroflex
  5. Forbaxin
  6. Glycerylguaiacolate carbamate
  7. Glycerylguajacol-Carbamat
  8. Guaiacol glyceryl ether carbamate
  9. Guaiphenesin carbamate
  10. Guaiphenesine carbamate
  11. Lumirelax
  12. Methocal
  13. Metocarbamol
  14. Metocarbamolo
  15. Metofenia
  16. Metofenina
  17. Miolaxene
  18. Miorilas
  19. Miowas
  20. Myolaxene
  21. Neuraxin
  22. Parabaxin
  23. Perilax
  24. Reflexyn
  25. Relestrid
  26. Robamol
  27. Robaxan
  28. Robaxin
  29. Robaxine
  30. Robaxon
  31. Robinax
  32. Romethocarb
  33. Surquetil
  34. Traumacut
  35. Tresortil
Brand Mixtures
  1. Extra Strength Muscle & Back Pain ASA (Acetylsalicylic acid + Methocarbamol)
  2. Methoxacet Extra Strength (Acetaminophen + Methocarbamol)
  3. Muscle & Back Pain ASA (Acetylsalicylic acid + Methocarbamol)
  4. Muscle & Back Pain Relief Caplets (Acetaminophen + Methocarbamol)
  5. Muscle & Back Pain Relief Extra Strength (Acetylsalicylic acid + Methocarbamol)
  6. Muscle Relaxant and Analgesic (Acetylsalicylic acid + Methocarbamol)
  7. Muscle and Back Pain Relief with Asa (Acetylsalicylic acid + Methocarbamol)
  8. Muscle and Back Pain Relief-8 (Acetaminophen + Codeine Phosphate + Methocarbamol)
  9. Robaxacet (Methocarbamol + Acetaminophen)
Chemical IUPAC Name [2-hydroxy-3-(2-methoxyphenoxy)propyl] carbamate
Chemical Formula C11H15NO5
Chemical Structure Structure
CAS Registry Number 532-03-6
InChI Identifier InChI=1/C11H15NO5/c1-15-9-4-2-3-5-10(9)16-6-8(13)7-17-11(12)14/h2-5,8,13H,6-7H2,1H3,(H2,12,14)/f/h12H2
InChI Key GNXFOGHNGIVQEH-GAJRPKRDCZ
KEGG Drug D00402 Link Image
KEGG Compound Not Available
PubChem Compound 4107 Link Image
PubChem Substance 7847468 Link Image
ChEBI ID Not Available
PharmGKB ID PA450424 Link Image
HET ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 00731110 Link Image
RxList Link http://www.rxlist.com/cgi/generic/methocar.htm Link Image
PDRhealth Link http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/rob1384.shtml Link Image
Wikipedia Link http://en.wikipedia.org/wiki/Methocarbamol Link Image
FDA Label
Material Safety Data Sheet (MSDS) Not Available
Synthesis Reference Not Available
Average Molecular Weight 241.2405
Monoisotopic Molecular Weight 241.0950
State Solid
Melting Point 93 oC
Experimental Water Solubility 7200 mg/L Source: PhysProp
Predicted Water Solubility 4.20e+00 mg/mL Calculated using ALOGPS
Experimental LogP/Hydrophobicity 0.1 Source: PhysProp
Predicted LogP 0.63 Calculated using ALOGPS
Experimental LogS Not Available
Predicted LogS -1.76 Calculated using ALOGPS
Experimental Caco2 Permeability Not Available
pKa/Isoelectric Point Not Available
Mass Spectrum Not Available
MOL File Show Link Image | Download Link Image
SDF File Show Link Image | Download Link Image
PDB File Show Link Image | Download Link Image
2D Structure
3D Structure
Experimental PDB ID Not Available
Isomeric SMILES COC1=CC=CC=C1OC[C@@H](O)COC(N)=O
Canonical SMILES COC1=CC=CC=C1OCC(O)COC(N)=O
Drug Category
  • Muscle Relaxants, Central
ATC Codes
AHFS Codes
  • 12:20.00
Indication For use as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions.
Pharmacology Methocarbamol is a central muscle relaxant for skeletal muscles, used to treat spasms. It is structurally related to guaifenesin. Methocarbamol's exact mechanism of causing skeletal muscle relaxation is unknown. It is thought to work centrally, perhaps by general depressant effects. It has no direct relaxant effects on striated muscle, nerve fibers, or the motor endplate. It will not directly relax contracted skeletal muscles. The drug has a secondary sedative effect.
Mechanism of Action The mechanism of action of methocarbamol in humans has not been established, but may be due to central nervous system depression. It has no direct action on the contractile mechanism of striated muscle, the motor end plate or the nerve fiber.
Absorption Rapid. Onset of action is about 30 minutes after oral administration.
Toxicity Symptoms of overdose include blurred vision, coma, drowsiness, low blood pressure, nausea, and seizures.
Protein Binding Not Available
Biotransformation Hepatic.
Half Life 1.14-1.24 hours
Dosage Forms
Form Route
Liquid Intramuscular
Liquid Intravenous
Tablet Oral
Patient Information Not Available
Contraindications Show Link Image
Interactions Show Link Image
Drug Interactions Not Available
Food Interactions
  • Avoid alcohol.
  • Take without regard to meals.
Pathways Not Available
General References
  1. Sica DA, Comstock TJ, Davis J, Manning L, Powell R, Melikian A, Wright G: Pharmacokinetics and protein binding of methocarbamol in renal insufficiency and normals. Eur J Clin Pharmacol. 1990;39(2):193-4. [PubMed Link Image]
  2. Drugs.com Link Image
  3. Wikipedia Link Image
  4. RxList Link Image
  5. PDRhealth Link Image
Organisms Affected
  • Humans and other mammals

This project is supported by Genome Alberta & Genome Canada, a not-for-profit organization that is leading Canada's national genomics strategy with $600 million in funding from the federal government. This project is also supported in part by GenomeQuest, Inc., an enterprise genomic information company serving the life science community.