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Identification
Name Felypressin
Accession Number DB00093 (BIOD00114, BTD00114)
Type biotech
Groups approved
Description

Synthetic analog of lypressin with more vasoconstrictor than antidiuretic action. It is used as a hemostatic.
Protein structure No_structure_small
Protein chemical formula C46H65N13O11S2
Protein average weight 1040.2190
Sequences 
>DE = Felypressin
CFFQNCPKG

FASTA
Synonyms
2-(L-Phenylalanine)-8-L-lysinevasopressin
Salts Not Available
Brand names
Name Company
Felipresina [INN-Spanish]
Felipressina [DCIT]
Felypressin [USAN:BAN:INN]
Felypressine [INN-French]
Felypressinum [INN-Latin]
Octapressin
Brand mixtures Not Available
Categories
  • Renal Agents
  • Vasoconstrictor Agents
CAS number 56-59-7
Taxonomy
Kingdom Not Available
Classes Not Available
Substructures Not Available
Pharmacology
Indication For use as an alternative to adrenaline as a localising agent, provided that local ischaemia is not essential.
Pharmacodynamics Felypressin is a synthetic analog of lypressin or vasopressin with more vasoconstrictor activity than antidiuretic action. It is used primarily as a hemostatic. Felypressin is a non-catecholamine vasoconstrictor that is chemically related to vasopressin, the posterior pituitary hormone.
Mechanism of action Felypressin binds to the vasopressin receptor V1a. This causes contraction of the smooth muscle in the vascular bed, especially capillaries, small arterioles and venules.
Absorption Not Available
Volume of distribution Not Available
Protein binding Not Available
Metabolism Not Available
Route of elimination Not Available
Half life Not Available
Clearance Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Pathways Not Available
Pharmacoeconomics
Manufacturers
  • Novartis pharmaceuticals corp
Packagers Not Available
Dosage forms Not Available
Prices Not Available
Patents Not Available
Properties
State solid
Experimental Properties
Property Value Source
hydrophobicity -3.6 Not Available
References
Synthesis Reference Not Available
General Reference
  1. Sequence Information Link
  2. Cecanho R, De Luca LA Jr, Ranali J: Cardiovascular effects of felypressin. Anesth Prog. 2006 Winter;53(4):119-25. Pubmed
External Links
Resource Link
PharmGKB PA164744374 Link_out
Wikipedia http://en.wikipedia.org/wiki/Felypressin Link_out
ATC Codes Not Available
AHFS Codes Not Available
PDB Entries Not Available
FDA label Not Available
MSDS Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available
Targets

1. Vasopressin V1a receptor

Pharmacological action: yes
Actions: agonist

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment

Organism class: human
UniProt ID: P37288 Link_out
Gene: AVPR1A Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Manning M, Stoev S, Chini B, Durroux T, Mouillac B, Guillon G: Peptide and non-peptide agonists and antagonists for the vasopressin and oxytocin V1a, V1b, V2 and OT receptors: research tools and potential therapeutic agents. Prog Brain Res. 2008;170:473-512. Pubmed
  4. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. Pubmed
Comments
Drug created on June 13, 2005 07:24 / Updated on September 29, 2010 14:34