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Identification
NameSulfadiazine
Accession NumberDB00359  (APRD00190)
TypeSmall Molecule
GroupsApproved, Vet Approved
DescriptionOne of the short-acting sulfonamides used in combination with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections. [PubChem]
Structure
Thumb
Synonyms
2-sulfanilamidopyrimidine
2-sulfanilylaminopyrimidine
4-amino-N-2-pyrimidinylbenzenesulfonamide
N(1)-2-Pyrimidinylsulfanilamide
N(1)-2-Pyrimidylsulfanilamide
N1-2-pyrimidinylsulfanilamide
N1-2-pyrimidylsulfanilamide
Sulfadiazina
Sulfadiazine
Sulfadiazinum
Sulfapyrimidine
Sulphadiazine
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Sulfadiazine Tab 7.7grtablet500.5 mgoralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1957-12-312001-07-20Canada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Sulfadiazinetablet500 mg/1oralEon Labs, Inc.1994-07-29Not applicableUs
Sulfadiazinetablet500 mg/1oralREMEDYREPACK INC.2013-02-11Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
AdiazineNot Available
Brand mixtures
NameLabellerIngredients
Coptin Oral SuspensionAxcan Pharma Inc
Coptin TabPfizer Canada Inc
Trisulfaminic SusShepherd Pharmaceuticals Inc.
Trisulfaminic TabShepherd Pharmaceuticals Inc.
Salts
Name/CASStructureProperties
Sulfadiazine sodium
ThumbNot applicableDBSALT001400
Categories
UNII0N7609K889
CAS number68-35-9
WeightAverage: 250.277
Monoisotopic: 250.052446274
Chemical FormulaC10H10N4O2S
InChI KeyInChIKey=SEEPANYCNGTZFQ-UHFFFAOYSA-N
InChI
InChI=1S/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H,12,13,14)
IUPAC Name
4-amino-N-(pyrimidin-2-yl)benzene-1-sulfonamide
SMILES
NC1=CC=C(C=C1)S(=O)(=O)NC1=NC=CC=N1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as aminobenzenesulfonamides. These are organic compounds containing a benzenesulfonamide moiety with an amine group attached to the benzene ring.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassBenzenesulfonamides
Direct ParentAminobenzenesulfonamides
Alternative Parents
Substituents
  • Aminobenzenesulfonamide
  • Sulfonylaniline
  • Substituted aniline
  • Aniline
  • Pyrimidine
  • Primary aromatic amine
  • Heteroaromatic compound
  • Aminosulfonyl compound
  • Sulfonyl
  • Sulfonic acid derivative
  • Sulfonamide
  • Azacycle
  • Organoheterocyclic compound
  • Hydrocarbon derivative
  • Primary amine
  • Organosulfur compound
  • Organonitrogen compound
  • Amine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of rheumatic fever and meningococcal meningitis
PharmacodynamicsSulfadiazine is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
Mechanism of actionSulfadiazine is a competitive inhibitor of the bacterial enzyme dihydropteroate synthetase. This enzyme is needed for the proper processing of para-aminobenzoic acid (PABA) which is essential for folic acid synthesis. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationSulfadiazine is excreted largely in the urine.
Half lifeNot Available
ClearanceNot Available
ToxicityOral LD50 in mouse is 1500 mg/kg.
Affected organisms
  • Enteric bacteria and other eubacteria
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9877
Blood Brain Barrier+0.9383
Caco-2 permeable+0.6988
P-glycoprotein substrateNon-substrate0.9012
P-glycoprotein inhibitor INon-inhibitor0.913
P-glycoprotein inhibitor IINon-inhibitor0.9156
Renal organic cation transporterNon-inhibitor0.8437
CYP450 2C9 substrateNon-substrate0.8031
CYP450 2D6 substrateNon-substrate0.915
CYP450 3A4 substrateNon-substrate0.7671
CYP450 1A2 substrateNon-inhibitor0.9574
CYP450 2C9 inhibitorNon-inhibitor0.922
CYP450 2D6 inhibitorNon-inhibitor0.9548
CYP450 2C19 inhibitorNon-inhibitor0.9693
CYP450 3A4 inhibitorNon-inhibitor0.902
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8569
Ames testNon AMES toxic0.9206
CarcinogenicityNon-carcinogens0.9393
BiodegradationNot ready biodegradable0.9973
Rat acute toxicity1.8353 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9383
hERG inhibition (predictor II)Non-inhibitor0.8673
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Abbott laboratories pharmaceutical products div
  • Everylife
  • Impax laboratories inc
  • Lannett co inc
  • Lederle laboratories div american cyanamid co
  • Eli lilly and co
  • Sandoz inc
Packagers
Dosage forms
FormRouteStrength
Suspensionoral
Tabletoral
Tabletoral500 mg/1
Tabletoral500.5 mg
Prices
Unit descriptionCostUnit
Silver Sulfadiazine 1% Cream 400 gm Jar36.48USD jar
Silver Sulfadiazine 1% Cream 50 gm Jar21.99USD jar
Silver Sulfadiazine 1% Cream 85 gm Jar19.99USD jar
Silver Sulfadiazine 1% Cream 25 gm Jar13.99USD jar
Sulfadiazine 500 mg tablet2.5USD tablet
Sulfazine EC 500 mg Enteric Coated Tabs0.42USD tab
Sulfazine ec 500 mg tablet0.38USD tablet
Sulfazine 500 mg tablet0.25USD tablet
Sulfadiazine powder0.13USD g
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point255.5 dec °CPhysProp
water solubility77 mg/L (at 25 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP-0.09HANSCH,C ET AL. (1995)
logS-3.51ADME Research, USCD
pKa6.36SANGSTER (1994)
Predicted Properties
PropertyValueSource
Water Solubility0.601 mg/mLALOGPS
logP0.25ALOGPS
logP0.39ChemAxon
logS-2.6ALOGPS
pKa (Strongest Acidic)6.99ChemAxon
pKa (Strongest Basic)2.01ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area97.97 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity64.2 m3·mol-1ChemAxon
Polarizability24.39 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (7.99 KB)
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis Reference

Charles L. Fox, Jr., Shanta M. Modak, Paul Fox, “Wound dressing comprising silver sulfadiazine incorporated in animal tissue and method of preparation.” U.S. Patent US4599226, issued September, 1977.

US4599226
General ReferencesNot Available
External Links
ATC CodesJ01EE06J01EE02J01EC02
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (73.5 KB)
Interactions
Drug Interactions
Drug
7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE may increase the hypoglycemic activities of Sulfadiazine.
AbirateroneThe serum concentration of Sulfadiazine can be increased when it is combined with Abiraterone.
AcarboseAcarbose may increase the hypoglycemic activities of Sulfadiazine.
AceclofenacThe metabolism of Aceclofenac can be decreased when combined with Sulfadiazine.
AcenocoumarolSulfadiazine may increase the anticoagulant activities of Acenocoumarol.
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Sulfadiazine.
AcetohexamideSulfadiazine may increase the hypoglycemic activities of Acetohexamide.
Acetylsalicylic acidAcetylsalicylic acid may increase the hypoglycemic activities of Sulfadiazine.
Acetylsalicylic acidThe metabolism of Acetylsalicylic acid can be decreased when combined with Sulfadiazine.
AicarAicar may increase the hypoglycemic activities of Sulfadiazine.
AlogliptinAlogliptin may increase the hypoglycemic activities of Sulfadiazine.
AlosetronThe metabolism of Alosetron can be decreased when combined with Sulfadiazine.
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Sulfadiazine.
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Sulfadiazine.
Aminosalicylic AcidAminosalicylic Acid may increase the hypoglycemic activities of Sulfadiazine.
AmiodaroneThe metabolism of Sulfadiazine can be decreased when combined with Amiodarone.
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Sulfadiazine.
AmoxapineAmoxapine may increase the hypoglycemic activities of Sulfadiazine.
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Sulfadiazine.
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Sulfadiazine.
ApixabanThe metabolism of Apixaban can be decreased when combined with Sulfadiazine.
AprepitantThe serum concentration of Sulfadiazine can be increased when it is combined with Aprepitant.
Arachidonic AcidThe metabolism of Arachidonic Acid can be decreased when combined with Sulfadiazine.
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Sulfadiazine.
ArtemetherThe metabolism of Artemether can be decreased when combined with Sulfadiazine.
AtazanavirThe metabolism of Sulfadiazine can be decreased when combined with Atazanavir.
AtomoxetineThe metabolism of Sulfadiazine can be decreased when combined with Atomoxetine.
AzelastineThe metabolism of Azelastine can be decreased when combined with Sulfadiazine.
BenmoxinBenmoxin may increase the hypoglycemic activities of Sulfadiazine.
BexaroteneThe serum concentration of Sulfadiazine can be decreased when it is combined with Bexarotene.
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Sulfadiazine.
BoceprevirThe metabolism of Sulfadiazine can be decreased when combined with Boceprevir.
BortezomibThe metabolism of Sulfadiazine can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Sulfadiazine can be decreased when it is combined with Bosentan.
BosentanThe serum concentration of Bosentan can be increased when it is combined with Sulfadiazine.
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Sulfadiazine.
BuforminBuformin may increase the hypoglycemic activities of Sulfadiazine.
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Sulfadiazine.
BupropionThe metabolism of Bupropion can be decreased when combined with Sulfadiazine.
CabozantinibThe metabolism of Cabozantinib can be decreased when combined with Sulfadiazine.
CaffeineThe metabolism of Caffeine can be decreased when combined with Sulfadiazine.
CanagliflozinCanagliflozin may increase the hypoglycemic activities of Sulfadiazine.
CandesartanThe metabolism of Candesartan can be decreased when combined with Sulfadiazine.
CapecitabineThe metabolism of Sulfadiazine can be decreased when combined with Capecitabine.
CarbamazepineThe metabolism of Sulfadiazine can be increased when combined with Carbamazepine.
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Sulfadiazine.
CaroxazoneCaroxazone may increase the hypoglycemic activities of Sulfadiazine.
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Sulfadiazine.
CastanospermineCastanospermine may increase the hypoglycemic activities of Sulfadiazine.
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Sulfadiazine.
CeritinibThe serum concentration of Sulfadiazine can be increased when it is combined with Ceritinib.
ChlorpropamideSulfadiazine may increase the hypoglycemic activities of Chlorpropamide.
CholecalciferolThe metabolism of Sulfadiazine can be decreased when combined with Cholecalciferol.
CiglitazoneCiglitazone may increase the hypoglycemic activities of Sulfadiazine.
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Sulfadiazine.
CisaprideThe metabolism of Cisapride can be decreased when combined with Sulfadiazine.
CitalopramCitalopram may increase the hypoglycemic activities of Sulfadiazine.
ClarithromycinThe metabolism of Sulfadiazine can be decreased when combined with Clarithromycin.
ClemastineThe metabolism of Sulfadiazine can be decreased when combined with Clemastine.
ClomipramineClomipramine may increase the hypoglycemic activities of Sulfadiazine.
ClopidogrelThe metabolism of Clopidogrel can be decreased when combined with Sulfadiazine.
ClotrimazoleThe metabolism of Sulfadiazine can be decreased when combined with Clotrimazole.
ClozapineThe metabolism of Clozapine can be decreased when combined with Sulfadiazine.
CobicistatThe metabolism of Sulfadiazine can be decreased when combined with Cobicistat.
ConivaptanThe serum concentration of Sulfadiazine can be increased when it is combined with Conivaptan.
CrizotinibThe metabolism of Sulfadiazine can be decreased when combined with Crizotinib.
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Sulfadiazine.
CyclosporineSulfadiazine may increase the nephrotoxic activities of Cyclosporine.
CyclosporineThe metabolism of Sulfadiazine can be decreased when combined with Cyclosporine.
Cyproterone acetateThe serum concentration of Sulfadiazine can be decreased when it is combined with Cyproterone acetate.
DabrafenibThe serum concentration of Sulfadiazine can be decreased when it is combined with Dabrafenib.
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Sulfadiazine.
DapoxetineDapoxetine may increase the hypoglycemic activities of Sulfadiazine.
DapsoneThe risk or severity of adverse effects can be increased when Dapsone is combined with Sulfadiazine.
DapsoneThe metabolism of Dapsone can be decreased when combined with Sulfadiazine.
DarunavirThe metabolism of Sulfadiazine can be decreased when combined with Darunavir.
DasatinibThe serum concentration of Sulfadiazine can be increased when it is combined with Dasatinib.
DeferasiroxThe serum concentration of Sulfadiazine can be decreased when it is combined with Deferasirox.
DelavirdineThe metabolism of Sulfadiazine can be decreased when combined with Delavirdine.
DexamethasoneThe serum concentration of Sulfadiazine can be decreased when it is combined with Dexamethasone.
DexketoprofenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Sulfadiazine.
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Sulfadiazine.
DiazepamThe metabolism of Diazepam can be decreased when combined with Sulfadiazine.
DiclofenacThe serum concentration of Diclofenac can be increased when it is combined with Sulfadiazine.
DicoumarolSulfadiazine may increase the anticoagulant activities of Dicoumarol.
DiflunisalDiflunisal may increase the hypoglycemic activities of Sulfadiazine.
DihydroergotamineThe metabolism of Sulfadiazine can be decreased when combined with Dihydroergotamine.
DihydrotestosteroneDihydrotestosterone may increase the hypoglycemic activities of Sulfadiazine.
DiltiazemThe metabolism of Sulfadiazine can be decreased when combined with Diltiazem.
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Sulfadiazine.
DisopyramideDisopyramide may increase the hypoglycemic activities of Sulfadiazine.
DisulfiramThe metabolism of Sulfadiazine can be decreased when combined with Disulfiram.
DolasetronThe metabolism of Dolasetron can be decreased when combined with Sulfadiazine.
DonepezilThe metabolism of Donepezil can be decreased when combined with Sulfadiazine.
DopamineThe metabolism of Dopamine can be decreased when combined with Sulfadiazine.
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Sulfadiazine.
DoxepinThe metabolism of Doxepin can be decreased when combined with Sulfadiazine.
DoxycyclineThe metabolism of Sulfadiazine can be decreased when combined with Doxycycline.
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Sulfadiazine.
DronedaroneThe metabolism of Sulfadiazine can be decreased when combined with Dronedarone.
DulaglutideDulaglutide may increase the hypoglycemic activities of Sulfadiazine.
EfavirenzThe serum concentration of Sulfadiazine can be decreased when it is combined with Efavirenz.
EletriptanThe metabolism of Eletriptan can be decreased when combined with Sulfadiazine.
EmpagliflozinEmpagliflozin may increase the hypoglycemic activities of Sulfadiazine.
EnzalutamideThe serum concentration of Sulfadiazine can be decreased when it is combined with Enzalutamide.
EpoprostenolThe metabolism of Epoprostenol can be decreased when combined with Sulfadiazine.
ErythromycinThe metabolism of Sulfadiazine can be decreased when combined with Erythromycin.
EscitalopramEscitalopram may increase the hypoglycemic activities of Sulfadiazine.
Eslicarbazepine acetateThe serum concentration of Sulfadiazine can be decreased when it is combined with Eslicarbazepine acetate.
EstradiolThe metabolism of Estradiol can be decreased when combined with Sulfadiazine.
EstroneThe metabolism of Estrone can be decreased when combined with Sulfadiazine.
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Sulfadiazine.
Ethyl biscoumacetateSulfadiazine may increase the anticoagulant activities of Ethyl biscoumacetate.
EtodolacThe metabolism of Etodolac can be decreased when combined with Sulfadiazine.
EtoperidoneEtoperidone may increase the hypoglycemic activities of Sulfadiazine.
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Sulfadiazine.
EtravirineThe serum concentration of Sulfadiazine can be decreased when it is combined with Etravirine.
EtravirineThe metabolism of Etravirine can be decreased when combined with Sulfadiazine.
ExenatideExenatide may increase the hypoglycemic activities of Sulfadiazine.
FelodipineThe metabolism of Sulfadiazine can be decreased when combined with Felodipine.
FenfluramineFenfluramine may increase the hypoglycemic activities of Sulfadiazine.
FloxuridineThe metabolism of Sulfadiazine can be decreased when combined with Floxuridine.
FluconazoleThe metabolism of Sulfadiazine can be decreased when combined with Fluconazole.
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Sulfadiazine.
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Sulfadiazine.
FluorouracilThe metabolism of Sulfadiazine can be decreased when combined with Fluorouracil.
FluoxetineFluoxetine may increase the hypoglycemic activities of Sulfadiazine.
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Sulfadiazine.
FluoxymesteroneFluoxymesterone may increase the hypoglycemic activities of Sulfadiazine.
FlurbiprofenThe metabolism of Flurbiprofen can be decreased when combined with Sulfadiazine.
FluvastatinThe metabolism of Sulfadiazine can be decreased when combined with Fluvastatin.
FluvoxamineFluvoxamine may increase the hypoglycemic activities of Sulfadiazine.
FormoterolThe metabolism of Formoterol can be decreased when combined with Sulfadiazine.
FosamprenavirThe metabolism of Sulfadiazine can be decreased when combined with Fosamprenavir.
FosaprepitantThe serum concentration of Sulfadiazine can be increased when it is combined with Fosaprepitant.
FosphenytoinThe metabolism of Sulfadiazine can be increased when combined with Fosphenytoin.
FurazolidoneFurazolidone may increase the hypoglycemic activities of Sulfadiazine.
Fusidic AcidThe serum concentration of Sulfadiazine can be increased when it is combined with Fusidic Acid.
GavestinelThe metabolism of Gavestinel can be decreased when combined with Sulfadiazine.
GemfibrozilThe metabolism of Sulfadiazine can be decreased when combined with Gemfibrozil.
GlibornurideSulfadiazine may increase the hypoglycemic activities of Glibornuride.
GliclazideSulfadiazine may increase the hypoglycemic activities of Gliclazide.
GlimepirideSulfadiazine may increase the hypoglycemic activities of Glimepiride.
GlipizideSulfadiazine may increase the hypoglycemic activities of Glipizide.
GliquidoneSulfadiazine may increase the hypoglycemic activities of Gliquidone.
GlisoxepideSulfadiazine may increase the hypoglycemic activities of Glisoxepide.
GlyburideSulfadiazine may increase the hypoglycemic activities of Glyburide.
GuanfacineThe metabolism of Guanfacine can be decreased when combined with Sulfadiazine.
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Sulfadiazine.
HalothaneThe metabolism of Halothane can be decreased when combined with Sulfadiazine.
HexamethylenetetramineThe risk or severity of adverse effects can be increased when Hexamethylenetetramine is combined with Sulfadiazine.
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Sulfadiazine.
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Sulfadiazine.
HydracarbazineHydracarbazine may increase the hypoglycemic activities of Sulfadiazine.
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Sulfadiazine.
IbuprofenThe metabolism of Ibuprofen can be decreased when combined with Sulfadiazine.
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Sulfadiazine.
IdelalisibThe serum concentration of Sulfadiazine can be increased when it is combined with Idelalisib.
IfosfamideThe metabolism of Ifosfamide can be decreased when combined with Sulfadiazine.
ImatinibThe metabolism of Sulfadiazine can be decreased when combined with Imatinib.
IndalpineIndalpine may increase the hypoglycemic activities of Sulfadiazine.
IndinavirThe metabolism of Sulfadiazine can be decreased when combined with Indinavir.
indisulamThe metabolism of indisulam can be decreased when combined with Sulfadiazine.
IndomethacinThe metabolism of Indomethacin can be decreased when combined with Sulfadiazine.
Insulin AspartInsulin Aspart may increase the hypoglycemic activities of Sulfadiazine.
Insulin DetemirInsulin Detemir may increase the hypoglycemic activities of Sulfadiazine.
Insulin GlargineInsulin Glargine may increase the hypoglycemic activities of Sulfadiazine.
Insulin GlulisineInsulin Glulisine may increase the hypoglycemic activities of Sulfadiazine.
Insulin HumanInsulin Human may increase the hypoglycemic activities of Sulfadiazine.
Insulin LisproInsulin Lispro may increase the hypoglycemic activities of Sulfadiazine.
Insulin PorkInsulin Pork may increase the hypoglycemic activities of Sulfadiazine.
IproclozideIproclozide may increase the hypoglycemic activities of Sulfadiazine.
IproniazidIproniazid may increase the hypoglycemic activities of Sulfadiazine.
IrbesartanThe metabolism of Sulfadiazine can be decreased when combined with Irbesartan.
IsavuconazoniumThe metabolism of Sulfadiazine can be decreased when combined with Isavuconazonium.
IsocarboxazidIsocarboxazid may increase the hypoglycemic activities of Sulfadiazine.
IsoniazidThe metabolism of Sulfadiazine can be decreased when combined with Isoniazid.
IsradipineThe metabolism of Sulfadiazine can be decreased when combined with Isradipine.
ItraconazoleThe metabolism of Sulfadiazine can be decreased when combined with Itraconazole.
IvacaftorThe serum concentration of Sulfadiazine can be increased when it is combined with Ivacaftor.
IxazomibThe metabolism of Ixazomib can be decreased when combined with Sulfadiazine.
KetamineThe metabolism of Ketamine can be decreased when combined with Sulfadiazine.
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Sulfadiazine.
KetoconazoleThe metabolism of Sulfadiazine can be decreased when combined with Ketoconazole.
KetoprofenThe metabolism of Ketoprofen can be decreased when combined with Sulfadiazine.
LacosamideThe serum concentration of Lacosamide can be increased when it is combined with Sulfadiazine.
LanreotideSulfadiazine may increase the hypoglycemic activities of Lanreotide.
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Sulfadiazine.
LapatinibThe metabolism of Sulfadiazine can be decreased when combined with Lapatinib.
LeflunomideThe metabolism of Sulfadiazine can be decreased when combined with Leflunomide.
LesinuradThe metabolism of Lesinurad can be decreased when combined with Sulfadiazine.
LevomilnacipranLevomilnacipran may increase the hypoglycemic activities of Sulfadiazine.
LicofeloneThe metabolism of Licofelone can be decreased when combined with Sulfadiazine.
LidocaineThe metabolism of Lidocaine can be decreased when combined with Sulfadiazine.
LinagliptinLinagliptin may increase the hypoglycemic activities of Sulfadiazine.
LiraglutideLiraglutide may increase the hypoglycemic activities of Sulfadiazine.
LopinavirThe metabolism of Sulfadiazine can be decreased when combined with Lopinavir.
LoratadineThe metabolism of Loratadine can be decreased when combined with Sulfadiazine.
LornoxicamThe metabolism of Lornoxicam can be decreased when combined with Sulfadiazine.
LosartanThe metabolism of Sulfadiazine can be decreased when combined with Losartan.
LovastatinThe metabolism of Sulfadiazine can be decreased when combined with Lovastatin.
Lu AA21004Lu AA21004 may increase the hypoglycemic activities of Sulfadiazine.
LuliconazoleThe serum concentration of Sulfadiazine can be increased when it is combined with Luliconazole.
LumacaftorThe serum concentration of Sulfadiazine can be decreased when it is combined with Lumacaftor.
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Sulfadiazine.
MebanazineMebanazine may increase the hypoglycemic activities of Sulfadiazine.
MecamylamineThe risk or severity of adverse effects can be increased when Sulfadiazine is combined with Mecamylamine.
MecaserminSulfadiazine may increase the hypoglycemic activities of Mecasermin.
Mefenamic acidThe metabolism of Mefenamic acid can be decreased when combined with Sulfadiazine.
MelatoninThe metabolism of Melatonin can be decreased when combined with Sulfadiazine.
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Sulfadiazine.
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Sulfadiazine.
MesalazineMesalazine may increase the hypoglycemic activities of Sulfadiazine.
MestranolThe metabolism of Mestranol can be decreased when combined with Sulfadiazine.
MetforminMetformin may increase the hypoglycemic activities of Sulfadiazine.
MethadoneThe metabolism of Methadone can be decreased when combined with Sulfadiazine.
MethotrexateThe risk or severity of adverse effects can be increased when Sulfadiazine is combined with Methotrexate.
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Sulfadiazine.
Methylene blueMethylene blue may increase the hypoglycemic activities of Sulfadiazine.
MethyltestosteroneMethyltestosterone may increase the hypoglycemic activities of Sulfadiazine.
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Sulfadiazine.
MifepristoneSulfadiazine may increase the hypoglycemic activities of Mifepristone.
MiglitolMiglitol may increase the hypoglycemic activities of Sulfadiazine.
MiglustatMiglustat may increase the hypoglycemic activities of Sulfadiazine.
MilnacipranMilnacipran may increase the hypoglycemic activities of Sulfadiazine.
MinaprineMinaprine may increase the hypoglycemic activities of Sulfadiazine.
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Sulfadiazine.
MitiglinideMitiglinide may increase the hypoglycemic activities of Sulfadiazine.
MitotaneThe serum concentration of Sulfadiazine can be decreased when it is combined with Mitotane.
MoclobemideMoclobemide may increase the hypoglycemic activities of Sulfadiazine.
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Sulfadiazine.
ModafinilThe serum concentration of Sulfadiazine can be decreased when it is combined with Modafinil.
MontelukastThe metabolism of Montelukast can be decreased when combined with Sulfadiazine.
NafcillinThe serum concentration of Sulfadiazine can be decreased when it is combined with Nafcillin.
NaproxenThe metabolism of Naproxen can be decreased when combined with Sulfadiazine.
NateglinideNateglinide may increase the hypoglycemic activities of Sulfadiazine.
NefazodoneThe metabolism of Sulfadiazine can be decreased when combined with Nefazodone.
NelfinavirThe metabolism of Sulfadiazine can be decreased when combined with Nelfinavir.
NetupitantThe serum concentration of Sulfadiazine can be increased when it is combined with Netupitant.
NetupitantThe metabolism of Netupitant can be decreased when combined with Sulfadiazine.
NevirapineThe metabolism of Sulfadiazine can be decreased when combined with Nevirapine.
NialamideNialamide may increase the hypoglycemic activities of Sulfadiazine.
NicardipineThe metabolism of Sulfadiazine can be decreased when combined with Nicardipine.
NiclosamideThe metabolism of Niclosamide can be decreased when combined with Sulfadiazine.
NicotineThe metabolism of Nicotine can be decreased when combined with Sulfadiazine.
NilotinibThe metabolism of Sulfadiazine can be decreased when combined with Nilotinib.
Nitric OxideThe risk or severity of adverse effects can be increased when Nitric Oxide is combined with Sulfadiazine.
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Sulfadiazine.
OctamoxinOctamoxin may increase the hypoglycemic activities of Sulfadiazine.
OctreotideOctreotide may increase the hypoglycemic activities of Sulfadiazine.
OlanzapineOlanzapine may increase the hypoglycemic activities of Sulfadiazine.
OlaparibThe metabolism of Sulfadiazine can be decreased when combined with Olaparib.
OlodaterolThe metabolism of Olodaterol can be decreased when combined with Sulfadiazine.
OmeprazoleThe metabolism of Sulfadiazine can be decreased when combined with Omeprazole.
OndansetronThe metabolism of Ondansetron can be decreased when combined with Sulfadiazine.
OsimertinibThe serum concentration of Sulfadiazine can be increased when it is combined with Osimertinib.
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Sulfadiazine.
OxandroloneOxandrolone may increase the hypoglycemic activities of Sulfadiazine.
OxaprozinThe metabolism of Oxaprozin can be decreased when combined with Sulfadiazine.
OxymetholoneOxymetholone may increase the hypoglycemic activities of Sulfadiazine.
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Sulfadiazine.
PalbociclibThe serum concentration of Sulfadiazine can be increased when it is combined with Palbociclib.
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Sulfadiazine.
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Sulfadiazine.
PargylinePargyline may increase the hypoglycemic activities of Sulfadiazine.
ParoxetineParoxetine may increase the hypoglycemic activities of Sulfadiazine.
PasireotideSulfadiazine may increase the hypoglycemic activities of Pasireotide.
PegvisomantPegvisomant may increase the hypoglycemic activities of Sulfadiazine.
PentamidineSulfadiazine may increase the hypoglycemic activities of Pentamidine.
PentobarbitalThe metabolism of Sulfadiazine can be increased when combined with Pentobarbital.
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Sulfadiazine.
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Sulfadiazine.
PhenelzinePhenelzine may increase the hypoglycemic activities of Sulfadiazine.
PhenforminPhenformin may increase the hypoglycemic activities of Sulfadiazine.
PhenindioneSulfadiazine may increase the anticoagulant activities of Phenindione.
PheniprazinePheniprazine may increase the hypoglycemic activities of Sulfadiazine.
PhenobarbitalThe metabolism of Sulfadiazine can be increased when combined with Phenobarbital.
PhenoxypropazinePhenoxypropazine may increase the hypoglycemic activities of Sulfadiazine.
PhenprocoumonSulfadiazine may increase the anticoagulant activities of Phenprocoumon.
PhenylbutazoneThe metabolism of Phenylbutazone can be decreased when combined with Sulfadiazine.
PhenytoinThe metabolism of Sulfadiazine can be increased when combined with Phenytoin.
PioglitazonePioglitazone may increase the hypoglycemic activities of Sulfadiazine.
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Sulfadiazine.
PirlindolePirlindole may increase the hypoglycemic activities of Sulfadiazine.
PiroxicamThe metabolism of Piroxicam can be decreased when combined with Sulfadiazine.
PitavastatinThe metabolism of Pitavastatin can be decreased when combined with Sulfadiazine.
PivhydrazinePivhydrazine may increase the hypoglycemic activities of Sulfadiazine.
PosaconazoleThe metabolism of Sulfadiazine can be decreased when combined with Posaconazole.
PramlintidePramlintide may increase the hypoglycemic activities of Sulfadiazine.
PrasugrelThe metabolism of Prasugrel can be decreased when combined with Sulfadiazine.
PravastatinThe metabolism of Pravastatin can be decreased when combined with Sulfadiazine.
PrilocaineThe risk or severity of adverse effects can be increased when Sulfadiazine is combined with Prilocaine.
PrimidoneThe metabolism of Sulfadiazine can be increased when combined with Primidone.
ProcaineThe therapeutic efficacy of Sulfadiazine can be decreased when used in combination with Procaine.
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Sulfadiazine.
ProguanilThe metabolism of Proguanil can be decreased when combined with Sulfadiazine.
PromazineThe metabolism of Promazine can be decreased when combined with Sulfadiazine.
PropofolThe metabolism of Propofol can be decreased when combined with Sulfadiazine.
PyrimethamineThe metabolism of Sulfadiazine can be decreased when combined with Pyrimethamine.
QuazepamThe metabolism of Quazepam can be decreased when combined with Sulfadiazine.
QuinidineThe metabolism of Quinidine can be decreased when combined with Sulfadiazine.
QuinineSulfadiazine may increase the hypoglycemic activities of Quinine.
RabeprazoleThe metabolism of Sulfadiazine can be decreased when combined with Rabeprazole.
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Sulfadiazine.
RanolazineThe metabolism of Sulfadiazine can be decreased when combined with Ranolazine.
RasagilineRasagiline may increase the hypoglycemic activities of Sulfadiazine.
RepaglinideRepaglinide may increase the hypoglycemic activities of Sulfadiazine.
RifabutinThe metabolism of Sulfadiazine can be increased when combined with Rifabutin.
RifampicinThe metabolism of Sulfadiazine can be increased when combined with Rifampicin.
RifapentineThe metabolism of Sulfadiazine can be increased when combined with Rifapentine.
RitonavirThe metabolism of Sulfadiazine can be decreased when combined with Ritonavir.
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Sulfadiazine.
RosiglitazoneRosiglitazone may increase the hypoglycemic activities of Sulfadiazine.
RosiglitazoneThe metabolism of Rosiglitazone can be decreased when combined with Sulfadiazine.
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Sulfadiazine.
SafrazineSafrazine may increase the hypoglycemic activities of Sulfadiazine.
Salicylic acidSalicylic acid may increase the hypoglycemic activities of Sulfadiazine.
Salicylic acidThe metabolism of Salicylic acid can be decreased when combined with Sulfadiazine.
SaquinavirThe metabolism of Sulfadiazine can be decreased when combined with Saquinavir.
SaxagliptinSaxagliptin may increase the hypoglycemic activities of Sulfadiazine.
SecobarbitalThe metabolism of Sulfadiazine can be increased when combined with Secobarbital.
SelegilineSelegiline may increase the hypoglycemic activities of Sulfadiazine.
SelegilineThe metabolism of Selegiline can be decreased when combined with Sulfadiazine.
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Sulfadiazine.
SertralineSertraline may increase the hypoglycemic activities of Sulfadiazine.
SertralineThe metabolism of Sertraline can be decreased when combined with Sulfadiazine.
SildenafilThe metabolism of Sulfadiazine can be decreased when combined with Sildenafil.
SiltuximabThe serum concentration of Sulfadiazine can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Sulfadiazine can be increased when it is combined with Simeprevir.
SitagliptinSitagliptin may increase the hypoglycemic activities of Sulfadiazine.
SitaxentanThe metabolism of Sitaxentan can be decreased when combined with Sulfadiazine.
Sodium NitriteThe risk or severity of adverse effects can be increased when Sulfadiazine is combined with Sodium Nitrite.
SorafenibThe metabolism of Sulfadiazine can be decreased when combined with Sorafenib.
St. John's WortThe serum concentration of Sulfadiazine can be decreased when it is combined with St. John's Wort.
StanozololStanozolol may increase the hypoglycemic activities of Sulfadiazine.
StiripentolThe serum concentration of Sulfadiazine can be increased when it is combined with Stiripentol.
SulfamethoxazoleSulfadiazine may increase the hypoglycemic activities of Sulfamethoxazole.
SulfamoxoleThe metabolism of Sulfamoxole can be decreased when combined with Sulfadiazine.
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Sulfadiazine.
SulfisoxazoleSulfisoxazole may increase the hypoglycemic activities of Sulfadiazine.
SulodexideSulodexide may increase the hypoglycemic activities of Sulfadiazine.
SunitinibSulfadiazine may increase the hypoglycemic activities of Sunitinib.
SuprofenThe metabolism of Suprofen can be decreased when combined with Sulfadiazine.
TamoxifenThe metabolism of Tamoxifen can be decreased when combined with Sulfadiazine.
TapentadolThe metabolism of Tapentadol can be decreased when combined with Sulfadiazine.
TelaprevirThe metabolism of Sulfadiazine can be decreased when combined with Telaprevir.
TelithromycinThe metabolism of Sulfadiazine can be decreased when combined with Telithromycin.
TemazepamThe metabolism of Temazepam can be decreased when combined with Sulfadiazine.
TenoxicamThe metabolism of Tenoxicam can be decreased when combined with Sulfadiazine.
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Sulfadiazine.
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Sulfadiazine.
TeriflunomideThe metabolism of Sulfadiazine can be decreased when combined with Teriflunomide.
TestosteroneTestosterone may increase the hypoglycemic activities of Sulfadiazine.
TestosteroneThe metabolism of Testosterone can be decreased when combined with Sulfadiazine.
ThalidomideThe metabolism of Thalidomide can be decreased when combined with Sulfadiazine.
TheophyllineThe metabolism of Theophylline can be decreased when combined with Sulfadiazine.
ThiamylalThe metabolism of Thiamylal can be decreased when combined with Sulfadiazine.
TicagrelorThe metabolism of Sulfadiazine can be decreased when combined with Ticagrelor.
TiclopidineThe metabolism of Sulfadiazine can be decreased when combined with Ticlopidine.
TocilizumabThe serum concentration of Sulfadiazine can be decreased when it is combined with Tocilizumab.
TolazamideSulfadiazine may increase the hypoglycemic activities of Tolazamide.
TolbutamideSulfadiazine may increase the hypoglycemic activities of Tolbutamide.
ToloxatoneToloxatone may increase the hypoglycemic activities of Sulfadiazine.
TolterodineThe metabolism of Tolterodine can be decreased when combined with Sulfadiazine.
TorasemideThe metabolism of Torasemide can be decreased when combined with Sulfadiazine.
TrabectedinThe metabolism of Trabectedin can be decreased when combined with Sulfadiazine.
Trans-2-PhenylcyclopropylamineTrans-2-Phenylcyclopropylamine may increase the hypoglycemic activities of Sulfadiazine.
TranylcypromineTranylcypromine may increase the hypoglycemic activities of Sulfadiazine.
TrazodoneTrazodone may increase the hypoglycemic activities of Sulfadiazine.
TreprostinilThe metabolism of Treprostinil can be decreased when combined with Sulfadiazine.
TretinoinThe metabolism of Tretinoin can be decreased when combined with Sulfadiazine.
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Sulfadiazine.
TrimethoprimThe metabolism of Sulfadiazine can be decreased when combined with Trimethoprim.
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Sulfadiazine.
TroglitazoneTroglitazone may increase the hypoglycemic activities of Sulfadiazine.
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Sulfadiazine.
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Sulfadiazine.
Valproic AcidThe metabolism of Sulfadiazine can be decreased when combined with Valproic Acid.
ValsartanThe metabolism of Sulfadiazine can be decreased when combined with Valsartan.
VenlafaxineThe metabolism of Sulfadiazine can be decreased when combined with Venlafaxine.
VerapamilThe metabolism of Sulfadiazine can be decreased when combined with Verapamil.
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Sulfadiazine.
VilazodoneVilazodone may increase the hypoglycemic activities of Sulfadiazine.
VildagliptinVildagliptin may increase the hypoglycemic activities of Sulfadiazine.
VismodegibThe metabolism of Vismodegib can be decreased when combined with Sulfadiazine.
VogliboseVoglibose may increase the hypoglycemic activities of Sulfadiazine.
VoriconazoleThe metabolism of Sulfadiazine can be decreased when combined with Voriconazole.
VortioxetineVortioxetine may increase the hypoglycemic activities of Sulfadiazine.
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Sulfadiazine.
WarfarinSulfadiazine may increase the anticoagulant activities of Warfarin.
XimelagatranThe metabolism of Ximelagatran can be decreased when combined with Sulfadiazine.
ZafirlukastThe metabolism of Sulfadiazine can be decreased when combined with Zafirlukast.
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Sulfadiazine.
ZaltoprofenThe metabolism of Zaltoprofen can be decreased when combined with Sulfadiazine.
ZidovudineThe metabolism of Zidovudine can be decreased when combined with Sulfadiazine.
ZileutonThe metabolism of Zileuton can be decreased when combined with Sulfadiazine.
ZimelidineZimelidine may increase the hypoglycemic activities of Sulfadiazine.
ZiprasidoneThe metabolism of Sulfadiazine can be decreased when combined with Ziprasidone.
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Sulfadiazine.
ZopicloneThe metabolism of Zopiclone can be decreased when combined with Sulfadiazine.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Plasmodium falciparum
Pharmacological action
yes
Actions
inhibitor
General Function:
Dihydropteroate synthase activity
Specific Function:
Not Available
Gene Name:
Not Available
Uniprot ID:
Q27738
Molecular Weight:
43370.845 Da
References
  1. de Araujo MV, Vieira EK, Silva Lazaro G, Conegero LS, Almeida LE, Barreto LS, da Costa NB Jr, Gimenez IF: Sulfadiazine/hydroxypropyl-beta-cyclodextrin host-guest system: Characterization, phase-solubility and molecular modeling. Bioorg Med Chem. 2008 May 15;16(10):5788-94. doi: 10.1016/j.bmc.2008.03.057. Epub 2008 Mar 27. [PubMed:18434167 ]
  2. Iliades P, Meshnick SR, Macreadie IG: Mutations in the Pneumocystis jirovecii DHPS gene confer cross-resistance to sulfa drugs. Antimicrob Agents Chemother. 2005 Feb;49(2):741-8. [PubMed:15673759 ]
  3. Prabhu V, Lui H, King J: Arabidopsis dihydropteroate synthase: general properties and inhibition by reaction product and sulfonamides. Phytochemistry. 1997 May;45(1):23-7. [PubMed:9127492 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Gene Name:
CYP2E1
Uniprot ID:
P05181
Molecular Weight:
56848.42 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23