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Identification
NameTimolol
Accession NumberDB00373  (APRD00229, DB08625)
TypeSmall Molecule
GroupsApproved
DescriptionA beta-adrenergic antagonist similar in action to propranolol. The levo-isomer is the more active. Timolol has been proposed as an antihypertensive, antiarrhythmic, antiangina, and antiglaucoma agent. It is also used in the treatment of migraine disorders and tremor. [PubChem]
Structure
Thumb
Synonyms
(S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
Timolol
Timolol anhydrous
Timololo
Timololum
External Identifiers
  • MK 950
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Beta-tim - 0.25% Liqliquid0.25 %ophthalmicCiba Vision Canada Inc1994-12-311998-07-16Canada
Beta-tim - 0.5% Liqliquid0.5 %ophthalmicCiba Vision Canada Inc1994-12-311998-07-16Canada
Betimolsolution/ drops5.12 mg/mLophthalmicOak Pharmaceuticals, Inc. (Subsidiary of Akorn, Inc.) (968937719)2014-01-02Not applicableUs
Betimolsolution2.5 mg/mLophthalmicVistakon Pharmaceuticals LLC2000-10-01Not applicableUs
Betimolsolution5 mg/mLophthalmicVistakon Pharmaceuticals LLC2000-10-01Not applicableUs
Betimolsolution/ drops2.56 mg/mLophthalmicOak Pharmaceuticals, Inc. (Subsidiary of Akorn, Inc.) (968937719)2014-01-02Not applicableUs
Blocadren Tab 10mgtablet10 mgoralMerck Frosst Canada & Cie, Merck Frosst Canada & Co.1977-12-312000-08-03Canada
Blocadren Tab 20mgtablet20 mgoralMerck Frosst Canada & Cie, Merck Frosst Canada & Co.1980-12-311999-03-02Canada
Blocadren Tab 5mgtablet5 mgoralMerck Frosst Canada & Cie, Merck Frosst Canada & Co.1978-12-312000-08-03Canada
Dom-timololliquid0.25 %ophthalmicDominion Pharmacal1999-03-08Not applicableCanada
Dom-timololliquid0.5 %ophthalmicDominion Pharmacal1999-03-08Not applicableCanada
Istalolsolution5 mg/mLophthalmicISTA Pharmaceuticals, Inc.2004-08-01Not applicableUs
Istalolsolution/ drops5 mg/mLophthalmicBausch & Lomb Incorporated2004-08-02Not applicableUs
Jamp-timololsolution5 mgophthalmicJamp Pharma Corporation2015-11-20Not applicableCanada
Med Timolol Liq Oph 0.25%liquid0.25 %ophthalmicMedican Pharma Incorporated1995-12-312011-03-29Canada
Med Timolol Liq Oph 0.5%liquid0.5 %ophthalmicMedican Pharma Incorporated1995-12-312011-03-29Canada
Mylan-timololsolution0.5 %ophthalmicMylan Pharmaceuticals Ulc1992-12-312012-10-19Canada
Mylan-timololsolution0.25 %ophthalmicMylan Pharmaceuticals Ulc1992-12-312012-10-19Canada
Novo-timol Liq 0.25%liquid0.25 %ophthalmicNovopharm Limited1993-12-312015-10-26Canada
Novo-timol Liq 0.5%liquid0.5 %ophthalmicNovopharm Limited1993-12-312015-10-26Canada
Nu-timolol Tab 10mgtablet10 mgoralNu Pharm Inc1993-12-312012-09-04Canada
Nu-timolol Tab 20mgtablet20 mgoralNu Pharm Inc1993-12-312012-09-04Canada
Nu-timolol Tab 5mgtablet5 mgoralNu Pharm Inc1993-12-312012-09-04Canada
Odan-timololliquid0.25 %ophthalmicOdan Laboratories Ltd1994-12-31Not applicableCanada
Odan-timololliquid0.5 %ophthalmicOdan Laboratories Ltd1994-12-31Not applicableCanada
PMS-timololliquid0.5 %ophthalmicPharmascience Inc1997-11-13Not applicableCanada
PMS-timololliquid0.25 %ophthalmicPharmascience Inc1997-11-13Not applicableCanada
Ratio-timolol Maleate 0.25%solution0.25 %ophthalmicRatiopharm Inc Division Of Teva Canada Limited2001-08-242006-08-04Canada
Ratio-timolol Maleate 0.5%solution0.5 %ophthalmicRatiopharm Inc Division Of Teva Canada Limited2001-08-242006-08-04Canada
Rhoxal-timolol 0.25%liquid0.25 %ophthalmicRhoxalpharma Inc2000-05-022009-11-24Canada
Rhoxal-timolol 0.5%liquid0.5 %ophthalmicRhoxalpharma Inc2000-05-022009-11-24Canada
Sandoz Timololsolution0.25 %ophthalmicSandoz Canada Incorporated1995-12-31Not applicableCanada
Sandoz Timololsolution0.5 %ophthalmicSandoz Canada Incorporated1995-12-31Not applicableCanada
T-LO - Liq Oph 0.25%liquid0.25 %ophthalmicAlcon Canada IncNot applicableNot applicableCanada
T-LO - Liq Oph 0.5%liquid0.5 %ophthalmicAlcon Canada IncNot applicableNot applicableCanada
Teva-timololtablet5 mgoralTeva Canada Limited1992-12-31Not applicableCanada
Teva-timololtablet20 mgoralTeva Canada Limited1992-12-31Not applicableCanada
Teva-timololtablet10 mgoralTeva Canada Limited1992-12-31Not applicableCanada
Timolol Gfssolution, gel forming, extended release2.5 mg/mLophthalmicSandoz Inc1998-12-24Not applicableUs
Timolol Gfssolution, gel forming, extended release5 mg/mLophthalmicSandoz Inc1998-12-24Not applicableUs
Timolol Maleatesolution6.8 mg/mLophthalmicREMEDYREPACK INC.2013-12-03Not applicableUs
Timolol Maleatesolution6.8 mg/mLophthalmicPhysicians Total Care, Inc.2002-10-16Not applicableUs
Timolol Maleatesolution2.5 mg/mLophthalmicAton Pharma, Inc.2009-10-15Not applicableUs
Timolol Maleatesolution5 mg/mLophthalmicAton Pharma, Inc.1993-11-14Not applicableUs
Timolol Maleate-EXsolution0.25 %ophthalmicAlcon Canada Inc2003-04-30Not applicableCanada
Timolol Maleate-EXsolution0.50 %ophthalmicAlcon Canada Inc2003-04-30Not applicableCanada
Timolol Solution - 0.25%solution.25 %ophthalmicBdh Inc.1998-10-132000-08-03Canada
Timolol Solution - 0.5%solution0.5 %ophthalmicBdh Inc.1998-10-132000-08-03Canada
Timolol-10 Tab 10mgtablet10 mgoralPro Doc Limitee1989-12-312011-07-27Canada
Timolol-20 Tab 20mgtablet20 mgoralPro Doc Limitee1989-12-312009-07-23Canada
Timolol-5 Tab 5mgtablet5 mgoralPro Doc Limitee1989-12-312011-07-27Canada
Timopticsolution2.5 mg/mLophthalmicAton Pharma, Inc.1986-11-05Not applicableUs
Timopticsolution0.25 %ophthalmicMerck Canada Inc1979-12-312006-11-22Canada
Timopticsolution6.8 mg/mLophthalmicValeant Pharmaceuticals North America LLC1986-11-05Not applicableUs
Timopticsolution5 mg/mLophthalmicAton Pharma, Inc.1986-11-05Not applicableUs
Timopticsolution3.4 mg/mLophthalmicValeant Pharmaceuticals North America LLC1986-11-05Not applicableUs
Timopticsolution0.5 %ophthalmicMerck Canada Inc1979-12-31Not applicableCanada
Timopticsolution2.5 mg/mLophthalmicAton Pharma, Inc.1978-08-17Not applicableUs
Timopticsolution5 mg/mLophthalmicAton Pharma, Inc.1978-08-17Not applicableUs
Timoptic-XEsolution5 mg/mLophthalmicAton Pharma, Inc.1993-11-14Not applicableUs
Timoptic-XEsolution (long-acting)0.25 %ophthalmicMerck Canada Inc1995-12-31Not applicableCanada
Timoptic-XEsolution (long-acting)0.5 %ophthalmicMerck Canada Inc1995-12-31Not applicableCanada
Timoptic-XEsolution2.5 mg/mLophthalmicAton Pharma, Inc.1993-11-14Not applicableUs
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-timol Tablets 10mgtablet10 mgoralApotex Inc1988-12-31Not applicableCanada
Apo-timol Tablets 20mgtablet20 mgoralApotex Inc1988-12-31Not applicableCanada
Apo-timol Tablets 5mgtablet5 mgoralApotex Inc1988-12-31Not applicableCanada
Apo-timop Gelsolution0.5 %ophthalmicApotex Inc2008-02-20Not applicableCanada
Apo-timop Gelsolution0.25 %ophthalmicApotex IncNot applicableNot applicableCanada
Apo-timop Liq 0.5%liquid0.5 %ophthalmicApotex Inc1988-12-31Not applicableCanada
Apo-timop Oph Soln 0.25%liquid0.25 %ophthalmicApotex Inc1988-12-31Not applicableCanada
Timolol Maleatesolution/ drops5 mg/mLophthalmicBausch & Lomb Incorporated1997-03-25Not applicableUs
Timolol Maleatesolution/ drops2.5 mg/mLophthalmicREMEDYREPACK INC.2015-11-17Not applicableUs
Timolol Maleatetablet5 mg/1oralMylan Pharmaceuticals Inc.1990-06-08Not applicableUs
Timolol Maleatesolution/ drops2.5 mg/mLophthalmicApotex Corp.2011-07-15Not applicableUs
Timolol Maleatesolution2.5 mg/mLophthalmicPhysicians Total Care, Inc.1996-01-26Not applicableUs
Timolol Maleatesolution/ drops5 mg/mLophthalmicPack Pharmaceuticals LLC2009-02-162016-01-23Us
Timolol Maleatesolution2.5 mg/mLophthalmicSandoz Inc1996-01-15Not applicableUs
Timolol Maleatesolution/ drops2.5 mg/mLophthalmicRising Pharmaceuticals, Inc.2014-12-15Not applicableUs
Timolol Maleatesolution/ drops2.5 mg/mLophthalmicBausch & Lomb Incorporated1997-03-25Not applicableUs
Timolol Maleatetablet10 mg/1oralMylan Pharmaceuticals Inc.1990-06-08Not applicableUs
Timolol Maleatesolution/ drops5 mg/mLophthalmicApotex Corp.2011-07-15Not applicableUs
Timolol Maleatesolution5 mg/mLophthalmicPhysicians Total Care, Inc.1995-01-26Not applicableUs
Timolol Maleatesolution/ drops5 mg/mLophthalmicAkorn, Inc.2012-03-26Not applicableUs
Timolol Maleatesolution5 mg/mLophthalmicSandoz Inc1996-01-15Not applicableUs
Timolol Maleatesolution/ drops5 mg/mLophthalmicHi Tech Pharmacal Co., Inc.2002-09-10Not applicableUs
Timolol Maleatesolution/ drops5 mg/mLophthalmicRising Pharmaceuticals, Inc.2014-12-15Not applicableUs
Timolol Maleatetablet20 mg/1oralMylan Pharmaceuticals Inc.1990-06-08Not applicableUs
Timolol Maleatesolution/ drops5 mg/mLophthalmicPacific Pharma, Inc.1997-05-20Not applicableUs
Timolol Maleatesolution/ drops2.5 mg/mLophthalmicFdc Limited2014-12-15Not applicableUs
Timolol Maleatesolution/ drops2.5 mg/mLophthalmicAkorn, Inc.2012-03-26Not applicableUs
Timolol Maleatesolution/ drops2.5 mg/mLophthalmicREMEDYREPACK INC.2015-06-16Not applicableUs
Timolol Maleatesolution/ drops5 mg/mLophthalmicREMEDYREPACK INC.2013-12-03Not applicableUs
Timolol Maleatesolution5 mg/mLophthalmicAscend Laboratories, LLC2011-03-09Not applicableUs
Timolol Maleatesolution/ drops2.5 mg/mLophthalmicPack Pharmaceuticals LLC2009-02-162016-01-23Us
Timolol Maleatesolution/ drops2.5 mg/mLophthalmicPacific Pharma, Inc.1997-05-20Not applicableUs
Timolol Maleatesolution/ drops5 mg/mLophthalmicFdc Limited2014-12-15Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
BlocadrenMerck
ProflaxSidus
TenoptSigma
Timacar DepotMSD
TimacorGerda
TimoptolMerck
Brand mixtures
NameLabellerIngredients
Act DorzotimololActavis Pharma Company
Act Latanoprost/timololActavis Pharma Company
Apo-brimonidine-timopApotex Inc
Apo-dorzo-timopApotex Inc
Apo-latanoprost-timopApotex Inc
Apo-travoprost-timopApotex Inc
AzargaAlcon Canada Inc
CombiganAllergan, Inc.
CosoptMerck Sharp & Dohme Corp.
Cosopt PFMerck Sharp & Dohme Corp.
Dorzolamide HCl /timolol MaleateREMEDYREPACK INC.
Dorzolamide HCl and Timolol MaleateActavis Pharma, Inc.
Dorzolamide Hydrochloride and Timolol MaleateBausch & Lomb Incorporated
Dorzolamide Hydrochloride and Timolol Maleate Ophthalmic SolutionBausch & Lomb Inc
Dorzolamide Hydrochloride-timolol MaleateLannett Company, Inc.
Dorzolamide Hydrochloride-timolol Maleate Ophthalmic Solution Sterile Ophthalmic SolutionAlvogen Inc.
Duotrav PqAlcon Canada Inc
Gd-latanoprost/timololGenmed A Division Of Pfizer Canada Inc
Jamp-latanoprost/timololJamp Pharma Corporation
Med-dorzolamide-timololGeneric Medical Partners Inc
Med-latanoprost-timololGeneric Medical Partners Inc
Mint-dorzolamide/timololMint Pharmaceuticals Inc
Mint-latanoprost/timololMint Pharmaceuticals Inc
Mylan-dorzolamide/timololMylan Pharmaceuticals Ulc
Mylan-latanoprost/timololMylan Pharmaceuticals Ulc
PMS-dorzolamide-timololPharmascience Inc
PMS-latanoprost-timololPharmascience Inc
Preservative-free CosoptMerck Canada Inc
Riva-dorzolamide/timololLaboratoire Riva Inc
Sandoz Dorzolamide/timololSandoz Canada Incorporated
Sandoz Latanoprost/timololSandoz Canada Incorporated
Sandoz Travoprost / Timolol PqSandoz Canada Incorporated
Teva-dorzotimolTeva Canada Limited
Teva-latanoprost/timololTeva Canada Limited
Timolide TabMerck Frosst Canada & Cie, Merck Frosst Canada & Co.
Timpilo 2Merck Canada Inc
Timpilo 4Merck Canada Inc
Van-dorzolamide-timololVanc Pharmaceuticals Inc
XalacomPfizer Canada Inc
Salts
Name/CASStructureProperties
Timolol hemihydrate
91524-16-2
Thumb
  • InChI Key: TWBNMYSKRDRHAT-RCWTXCDDSA-N
  • Monoisotopic Mass: 650.32438833
  • Average Mass: 650.86
DBSALT000990
Timolol maleate
26921-17-5
Thumb
  • InChI Key: WLRMANUAADYWEA-NWASOUNVSA-N
  • Monoisotopic Mass: 432.167870432
  • Average Mass: 432.49
DBSALT000989
Categories
UNII5JKY92S7BR
CAS number26839-75-8
WeightAverage: 316.42
Monoisotopic: 316.156911344
Chemical FormulaC13H24N4O3S
InChI KeyInChIKey=BLJRIMJGRPQVNF-UHFFFAOYSA-N
InChI
InChI=1S/C13H24N4O3S/c1-13(2,3)14-8-10(18)9-20-12-11(15-21-16-12)17-4-6-19-7-5-17/h10,14,18H,4-9H2,1-3H3
IUPAC Name
1-(tert-butylamino)-3-{[4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy}propan-2-ol
SMILES
CC(C)(C)NCC(O)COC1=NSN=C1N1CCOCC1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as dialkylarylamines. These are aliphatic aromatic amines in which the amino group is linked to two aliphatic chains and one aromatic group.
KingdomOrganic compounds
Super ClassOrganonitrogen compounds
ClassAmines
Sub ClassTertiary amines
Direct ParentDialkylarylamines
Alternative Parents
Substituents
  • Dialkylarylamine
  • Alkyl aryl ether
  • Imidolactam
  • Oxazinane
  • Morpholine
  • 3-amino-1,2,5-thiadiazole
  • Heteroaromatic compound
  • Thiadiazole
  • Azole
  • Secondary alcohol
  • 1,2-aminoalcohol
  • Oxacycle
  • Azacycle
  • Organoheterocyclic compound
  • Secondary amine
  • Ether
  • Secondary aliphatic amine
  • Dialkyl ether
  • Hydrocarbon derivative
  • Organooxygen compound
  • Alcohol
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationIn its oral form it is used to treat high blood pressure and prevent heart attacks, and occasionally to prevent migraine headaches. In its opthalmic form it is used to treat open-angle and occasionally secondary glaucoma.
PharmacodynamicsSimilar to propranolol and nadolol, timolol is a non-selective, beta-adrenergic receptor antagonist. Timolol does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anesthetic (membrane-stabilizing) activity, but does possess a relatively high degree of lipid solubility. Timolol, when applied topically to the eye, has the action of reducing elevated, as well as normal, intraocular pressure, whether or not accompanied by glaucoma. Elevated intraocular pressure is a major risk factor in the pathogenesis of glaucomatous visual field loss and optic nerve damage.
Mechanism of actionLike propranolol and nadolol, timolol competes with adrenergic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart and vascular smooth muscle and beta(2)-receptors in the bronchial and vascular smooth muscle. Beta(1)-receptor blockade results in a decrease in resting and exercise heart rate and cardiac output, a decrease in both systolic and diastolic blood pressure, and, possibly, a reduction in reflex orthostatic hypotension. Beta(2)-blockade results in an increase in peripheral vascular resistance. The exact mechanism whereby timolol reduces ocular pressure is still not known. The most likely action is by decreasing the secretion of aqueous humor.
Related Articles
AbsorptionBioavailability is about 60%
Volume of distributionNot Available
Protein binding~10%
Metabolism

Primarily hepatic (80%) via the cytochrome P450 2D6 isoenzyme.

Route of eliminationTimolol and its metabolites are primarily excreted in the urine.
Half life2.5-5 hours
ClearanceNot Available
ToxicityLD50=1190 mg/kg (oral, mice), LD50=900 mg/kg (oral, rat). Symptoms of overdose include drowsiness, vertigo, headache, and atriventricular block.
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Timolol Action PathwayDrug actionSMP00659
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9958
Blood Brain Barrier-0.6467
Caco-2 permeable+0.8867
P-glycoprotein substrateSubstrate0.8522
P-glycoprotein inhibitor INon-inhibitor0.6567
P-glycoprotein inhibitor IINon-inhibitor0.9552
Renal organic cation transporterNon-inhibitor0.9105
CYP450 2C9 substrateNon-substrate0.7898
CYP450 2D6 substrateSubstrate0.8918
CYP450 3A4 substrateSubstrate0.5389
CYP450 1A2 substrateNon-inhibitor0.9046
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorInhibitor0.8932
CYP450 2C19 inhibitorNon-inhibitor0.9026
CYP450 3A4 inhibitorNon-inhibitor0.8309
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8678
Ames testNon AMES toxic0.9132
CarcinogenicityNon-carcinogens0.7338
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.6096 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9214
hERG inhibition (predictor II)Non-inhibitor0.7334
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Santen oy
  • Falcon pharmaceuticals ltd
  • Aton pharma inc
  • Ista pharmaceuticals
  • Akorn inc
  • Bausch and lomb pharmaceuticals inc
  • Bausch and lomb inc
  • Falcon pharmaceuticals inc
  • Fdc ltd
  • E fougera div altana inc
  • Hi tech pharmacal co inc
  • Novex pharma
  • Pacific pharma inc
  • Pacific pharma
  • Wockhardt ltd
  • Merck research laboratories div merck co inc
  • Mylan pharmaceuticals inc
  • Quantum pharmics ltd
  • Sandoz inc
  • Teva pharmaceuticals usa inc
  • Usl pharma inc
  • Watson laboratories inc
Packagers
Dosage forms
FormRouteStrength
Suspensionophthalmic
Solution/ dropsophthalmic2.56 mg/mL
Solution/ dropsophthalmic5.12 mg/mL
Solution/ dropsophthalmic
Solutionophthalmic
Solutionophthalmic5 mg
Liquidophthalmic0.25 %
Liquidophthalmic0.5 %
Solutionophthalmic0.25 %
Solutionophthalmic0.5 %
Tabletoral10 mg
Tabletoral20 mg
Tabletoral5 mg
Tabletoral
Solution, gel forming, extended releaseophthalmic2.5 mg/mL
Solution, gel forming, extended releaseophthalmic5 mg/mL
Solution/ dropsophthalmic2.5 mg/mL
Solution/ dropsophthalmic5 mg/mL
Tabletoral10 mg/1
Tabletoral20 mg/1
Tabletoral5 mg/1
Solutionophthalmic0.50 %
Solutionophthalmic.25 %
Solutionophthalmic3.4 mg/mL
Solutionophthalmic6.8 mg/mL
Solutionophthalmic2.5 mg/mL
Solutionophthalmic5 mg/mL
Solution (long-acting)ophthalmic0.25 %
Solution (long-acting)ophthalmic0.5 %
Prices
Unit descriptionCostUnit
Betimol 0.5% Solution 15ml Bottle152.24USD bottle
Timolol maleate powder107.1USD g
Betimol 0.5% Solution 10ml Bottle106.88USD bottle
Betimol 0.25% Solution 15ml Bottle93.56USD bottle
Timoptic-XE 0.5% Gel Forming Solution 5ml Bottle85.09USD bottle
Timoptic 0.5% Solution 10ml Bottle83.2USD bottle
Timoptic-XE 0.25% Gel Forming Solution 5ml Bottle65.37USD bottle
Betimol 0.5% Solution 5ml Bottle63.43USD bottle
Timolol Maleate 0.5% Gel Forming Solution 5ml Bottle60.84USD bottle
Timoptic 0.5% Solution 5ml Bottle59.8USD bottle
Timolol Maleate 0.25% Gel Forming Solution 5ml Bottle59.71USD bottle
Betimol 0.25% Solution 5ml Bottle55.56USD bottle
Timolol Maleate 0.5% Solution 15ml Bottle50.7USD bottle
Betimol 0.25% Solution 10ml Bottle49.99USD bottle
Timolol Maleate 0.5% Gel Forming Solution 2.5ml Bottle46.74USD bottle
Timolol Maleate 0.25% Solution 15ml Bottle43.68USD bottle
Timoptic 0.25% Solution 5ml Bottle43.06USD bottle
Istalol 0.5% eye drops36.43USD ml
Timolol Maleate 0.5% Solution 10ml Bottle33.58USD bottle
Timolol Maleate 0.25% Solution 10ml Bottle28.87USD bottle
Timoptic-XE 0.25% Gel Forming Solution 2.5ml Bottle23.99USD bottle
Timolol Maleate 0.5% Solution 5ml Bottle17.68USD bottle
Timolol Maleate 0.25% Solution 5ml Bottle15.6USD bottle
Timoptic-xe 0.5% eye solution13.6USD ml
Timoptic-xe 0.25% eye solution11.51USD ml
Betimol 0.5% eye drops10.15USD ml
Betimol 0.25% eye drops9.19USD ml
Timoptic 0.5% eye drops8.63USD ml
Timoptic 0.25% eye drops7.32USD ml
Timoptic-Xe 0.5 % Long Acting Gellan Solution4.64USD ml
Timoptic 0.5% ocudose drops4.57USD each
Timoptic-Xe 0.25 % Long Acting Gellan Solution3.88USD ml
Timoptic 0.25% ocudose drops3.8USD each
Timoptic 0.5 % Solution3.63USD ml
Timolol 0.5% eye drops3.24USD ml
Timolol 0.25% eye drops2.78USD ml
Apo-Timop 0.5 % Solution1.95USD ml
Mylan-Timolol 0.5 % Solution1.95USD ml
Pms-Timolol 0.5 % Solution1.95USD ml
Sandoz Timolol Maleate 0.5 % Solution1.95USD ml
Apo-Timop 0.25 % Solution1.62USD ml
Mylan-Timolol 0.25 % Solution1.62USD ml
Pms-Timolol 0.25 % Solution1.62USD ml
Sandoz Timolol Maleate 0.25 % Solution1.62USD ml
Timolol maleate 20 mg tablet0.94USD tablet
Hydrocortisone 2.5% lotion0.6USD ml
Apo-Timol 20 mg Tablet0.59USD tablet
Novo-Timol 20 mg Tablet0.59USD tablet
Timolol maleate 10 mg tablet0.51USD tablet
Timolol maleate 5 mg tablet0.41USD tablet
Apo-Timol 10 mg Tablet0.3USD tablet
Novo-Timol 10 mg Tablet0.3USD tablet
Nu-Timolol 10 mg Tablet0.3USD tablet
Apo-Timol 5 mg Tablet0.19USD tablet
Novo-Timol 5 mg Tablet0.19USD tablet
Nu-Timolol 5 mg Tablet0.19USD tablet
Aquanil hc 1% lotion0.12USD ml
Aquanil cleanser0.03USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5231095 No1993-07-272010-07-27Us
US6174524 Yes1999-09-262019-09-26Us
US6335335 No1998-11-022018-11-02Us
US6645963 No1998-11-162018-11-16Us
US7030149 No2002-04-192022-04-19Us
US7320976 No2002-04-192022-04-19Us
US7323463 No2003-01-192023-01-19Us
US7642258 No2002-04-192022-04-19Us
US8133890 No2002-04-192022-04-19Us
US8354409 No2002-04-192022-04-19Us
US8748425 No2002-04-192022-04-19Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point202 °CPhysProp
water solubility2.74 mg/mLNot Available
logP1.83HANSCH,C ET AL. (1995)
Caco2 permeability-4.85ADME Research, USCD
pKa9.21KONTTURI,K & MURTOMAKI,L (1992)
Predicted Properties
PropertyValueSource
Water Solubility0.269 mg/mLALOGPS
logP1.44ALOGPS
logP1.34ChemAxon
logS-3.1ALOGPS
pKa (Strongest Acidic)14.08ChemAxon
pKa (Strongest Basic)9.76ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area79.74 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity83.92 m3·mol-1ChemAxon
Polarizability33.99 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis Reference

Markku Per alampi, “S-timolol hemihydrate composition and method of preparation therefor.” U.S. Patent US5574035, issued October, 1986.

US5574035
General References
  1. Link [Link]
External Links
ATC CodesC07DA06S01ED51S01ED01C07BA06C07AA06
AHFS Codes
  • 24:24.00
  • 52:92.00
PDB EntriesNot Available
FDA labelDownload (471 KB)
MSDSDownload (73.5 KB)
Interactions
Drug Interactions
Drug
1,10-Phenanthroline1,10-Phenanthroline may increase the bradycardic activities of Timolol.
4-Methoxyamphetamine4-Methoxyamphetamine may increase the atrioventricular blocking (AV block) activities of Timolol.
7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE may increase the hypotensive activities of Timolol.
AbirateroneThe metabolism of Timolol can be decreased when combined with Abiraterone.
AcebutololTimolol may increase the hypotensive activities of Acebutolol.
AceclofenacAceclofenac may decrease the antihypertensive activities of Timolol.
AcepromazineAcepromazine may increase the hypotensive activities of Timolol.
AcetaminophenThe serum concentration of Timolol can be increased when it is combined with Acetaminophen.
AcetazolamideThe risk or severity of adverse effects can be increased when Timolol is combined with Acetazolamide.
AcetohexamideTimolol may increase the hypoglycemic activities of Acetohexamide.
AcetylcholineThe risk or severity of adverse effects can be increased when Timolol is combined with Acetylcholine.
AcetyldigitoxinTimolol may increase the bradycardic activities of Acetyldigitoxin.
Acetylsalicylic acidAcetylsalicylic acid may decrease the antihypertensive activities of Timolol.
AdapaleneAdapalene may decrease the antihypertensive activities of Timolol.
AfatinibThe serum concentration of Timolol can be increased when it is combined with Afatinib.
AgmatineAgmatine may increase the atrioventricular blocking (AV block) activities of Timolol.
AlbendazoleThe serum concentration of Timolol can be increased when it is combined with Albendazole.
AldesleukinThe risk or severity of adverse effects can be increased when Aldesleukin is combined with Timolol.
AldosteroneThe serum concentration of Timolol can be decreased when it is combined with Aldosterone.
AlectinibThe serum concentration of Timolol can be increased when it is combined with Alectinib.
AlfentanilThe serum concentration of Timolol can be increased when it is combined with Alfentanil.
AlfuzosinAlfuzosin may increase the hypotensive activities of Timolol.
AlfuzosinTimolol may increase the orthostatic hypotensive activities of Alfuzosin.
AlimemazineAlimemazine may increase the hypotensive activities of Timolol.
AliskirenTimolol may increase the hypotensive activities of Aliskiren.
AlprenololTimolol may increase the hypotensive activities of Alprenolol.
AmantadineThe serum concentration of Timolol can be increased when it is combined with Amantadine.
AmbenoniumAmbenonium may increase the bradycardic activities of Timolol.
AmbrisentanTimolol may increase the hypotensive activities of Ambrisentan.
AmifostineTimolol may increase the hypotensive activities of Amifostine.
AmilorideThe risk or severity of adverse effects can be increased when Timolol is combined with Amiloride.
Aminohippuric acidThe serum concentration of Timolol can be increased when it is combined with Aminohippuric acid.
AminophyllineTimolol may decrease the bronchodilatory activities of Aminophylline.
AmiodaroneAmiodarone may increase the bradycardic activities of Timolol.
AmitriptylineThe serum concentration of Timolol can be increased when it is combined with Amitriptyline.
AmlodipineTimolol may increase the hypotensive activities of Amlodipine.
AmobarbitalAmobarbital may increase the hypotensive activities of Timolol.
AmodiaquineThe metabolism of Timolol can be decreased when combined with Amodiaquine.
AmoxapineThe serum concentration of Timolol can be increased when it is combined with Amoxapine.
AmprenavirThe serum concentration of Timolol can be decreased when it is combined with Amprenavir.
AmsacrineThe serum concentration of Timolol can be increased when it is combined with Amsacrine.
Amyl NitriteThe risk or severity of adverse effects can be increased when Timolol is combined with Amyl Nitrite.
AntipyrineAntipyrine may decrease the antihypertensive activities of Timolol.
ApomorphineApomorphine may increase the atrioventricular blocking (AV block) activities of Timolol.
ApraclonidineThe risk or severity of adverse effects can be increased when Timolol is combined with Apraclonidine.
ApremilastApremilast may decrease the antihypertensive activities of Timolol.
ArbutamineTimolol may decrease the bronchodilatory activities of Arbutamine.
ArecolineThe risk or severity of adverse effects can be increased when Timolol is combined with Arecoline.
ArformoterolTimolol may decrease the bronchodilatory activities of Arformoterol.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Timolol.
AripiprazoleAripiprazole may increase the hypotensive activities of Timolol.
ArmodafinilThe metabolism of Timolol can be decreased when combined with Armodafinil.
ArtemetherThe metabolism of Timolol can be decreased when combined with Artemether.
AstemizoleThe serum concentration of Timolol can be increased when it is combined with Astemizole.
AtazanavirThe serum concentration of Timolol can be increased when it is combined with Atazanavir.
AtenololAtenolol may increase the hypotensive activities of Timolol.
AtomoxetineThe metabolism of Timolol can be decreased when combined with Atomoxetine.
AtorvastatinThe serum concentration of Timolol can be increased when it is combined with Atorvastatin.
AzapropazoneAzapropazone may decrease the antihypertensive activities of Timolol.
AzelastineAzelastine may decrease the antihypertensive activities of Timolol.
Azilsartan medoxomilThe risk or severity of adverse effects can be increased when Timolol is combined with Azilsartan medoxomil.
AzithromycinThe serum concentration of Timolol can be increased when it is combined with Azithromycin.
BalsalazideBalsalazide may decrease the antihypertensive activities of Timolol.
BambuterolTimolol may decrease the bronchodilatory activities of Bambuterol.
BarbitalBarbital may increase the hypotensive activities of Timolol.
BenazeprilTimolol may increase the hypotensive activities of Benazepril.
BendroflumethiazideTimolol may increase the hypotensive activities of Bendroflumethiazide.
BenmoxinBenmoxin may increase the hypotensive activities of Timolol.
BenoxaprofenBenoxaprofen may decrease the antihypertensive activities of Timolol.
BenzocaineThe serum concentration of Timolol can be increased when it is combined with Benzocaine.
BenzphetamineBenzphetamine may increase the atrioventricular blocking (AV block) activities of Timolol.
BepridilTimolol may increase the hypotensive activities of Bepridil.
BeractantTimolol may increase the bradycardic activities of Beractant.
BetaxololBetaxolol may increase the hypotensive activities of Timolol.
BethanecholThe risk or severity of adverse effects can be increased when Timolol is combined with Bethanechol.
BethanidineBethanidine may increase the hypotensive activities of Timolol.
BimatoprostTimolol may increase the hypotensive activities of Bimatoprost.
BiperidenThe serum concentration of Timolol can be increased when it is combined with Biperiden.
BisoprololTimolol may increase the hypotensive activities of Bisoprolol.
BortezomibThe metabolism of Timolol can be decreased when combined with Bortezomib.
BosentanTimolol may increase the hypotensive activities of Bosentan.
BosutinibThe serum concentration of Timolol can be increased when it is combined with Bosutinib.
BretyliumBretylium may increase the bradycardic activities of Timolol.
BretyliumTimolol may increase the hypotensive activities of Bretylium.
BrimonidineTimolol may increase the hypotensive activities of Brimonidine.
BrimonidineBrimonidine may increase the antihypertensive activities of Timolol.
BromfenacBromfenac may decrease the antihypertensive activities of Timolol.
BromocriptineTimolol may increase the vasoconstricting activities of Bromocriptine.
BromocriptineThe serum concentration of Timolol can be increased when it is combined with Bromocriptine.
BumetanideThe risk or severity of adverse effects can be increased when Timolol is combined with Bumetanide.
BupivacaineThe serum concentration of Bupivacaine can be increased when it is combined with Timolol.
BupranololTimolol may increase the hypotensive activities of Bupranolol.
BuprenorphineThe serum concentration of Timolol can be increased when it is combined with Buprenorphine.
BupropionThe metabolism of Timolol can be decreased when combined with Bupropion.
BuspironeThe serum concentration of Timolol can be increased when it is combined with Buspirone.
CabazitaxelThe serum concentration of Timolol can be increased when it is combined with Cabazitaxel.
CabergolineTimolol may increase the vasoconstricting activities of Cabergoline.
CaffeineThe serum concentration of Timolol can be increased when it is combined with Caffeine.
CalfactantTimolol may increase the bradycardic activities of Calfactant.
CanagliflozinThe risk or severity of adverse effects can be increased when Timolol is combined with Canagliflozin.
CandesartanTimolol may increase the hypotensive activities of Candesartan.
CandoxatrilTimolol may increase the hypotensive activities of Candoxatril.
CaptoprilTimolol may increase the hypotensive activities of Captopril.
CarbacholThe risk or severity of adverse effects can be increased when Timolol is combined with Carbachol.
CarbamazepineThe serum concentration of Timolol can be decreased when it is combined with Carbamazepine.
CaroxazoneCaroxazone may increase the hypotensive activities of Timolol.
CarprofenCarprofen may decrease the antihypertensive activities of Timolol.
CarteololTimolol may increase the hypotensive activities of Carteolol.
CarvedilolTimolol may increase the hypotensive activities of Carvedilol.
CaspofunginThe serum concentration of Timolol can be increased when it is combined with Caspofungin.
CastanospermineCastanospermine may decrease the antihypertensive activities of Timolol.
CelecoxibCelecoxib may decrease the antihypertensive activities of Timolol.
CeliprololCeliprolol may increase the hypotensive activities of Timolol.
CeliprololTimolol may decrease the bronchodilatory activities of Celiprolol.
CeritinibTimolol may increase the bradycardic activities of Ceritinib.
CevimelineThe risk or severity of adverse effects can be increased when Timolol is combined with Cevimeline.
ChloramphenicolThe metabolism of Timolol can be decreased when combined with Chloramphenicol.
ChloroquineChloroquine may decrease the antihypertensive activities of Timolol.
ChlorothiazideTimolol may increase the hypotensive activities of Chlorothiazide.
ChlorpromazineChlorpromazine may increase the hypotensive activities of Timolol.
ChlorpropamideTimolol may increase the hypoglycemic activities of Chlorpropamide.
ChlorpropamideThe serum concentration of Timolol can be increased when it is combined with Chlorpropamide.
ChlorprothixeneThe serum concentration of Timolol can be increased when it is combined with Chlorprothixene.
ChlorthalidoneChlorthalidone may increase the hypotensive activities of Timolol.
CholecalciferolThe metabolism of Timolol can be decreased when combined with Cholecalciferol.
CholesterolThe serum concentration of Timolol can be increased when it is combined with Cholesterol.
Cholic AcidThe serum concentration of Timolol can be decreased when it is combined with Cholic Acid.
CilazaprilTimolol may increase the hypotensive activities of Cilazapril.
CimetidineThe serum concentration of Timolol can be decreased when it is combined with Cimetidine.
CinacalcetThe metabolism of Timolol can be decreased when combined with Cinacalcet.
CiprofloxacinThe serum concentration of Timolol can be increased when it is combined with Ciprofloxacin.
CitalopramThe serum concentration of Timolol can be increased when it is combined with Citalopram.
ClarithromycinThe serum concentration of Timolol can be increased when it is combined with Clarithromycin.
ClemastineThe metabolism of Timolol can be decreased when combined with Clemastine.
ClenbuterolTimolol may decrease the bronchodilatory activities of Clenbuterol.
ClevidipineThe risk or severity of adverse effects can be increased when Timolol is combined with Clevidipine.
ClobazamThe metabolism of Timolol can be decreased when combined with Clobazam.
ClofazimineThe serum concentration of Timolol can be increased when it is combined with Clofazimine.
ClomipramineThe serum concentration of Timolol can be increased when it is combined with Clomipramine.
ClonidineTimolol may increase the hypotensive activities of Clonidine.
ClonixinClonixin may decrease the antihypertensive activities of Timolol.
ClotrimazoleThe serum concentration of Timolol can be decreased when it is combined with Clotrimazole.
ClozapineThe metabolism of Timolol can be decreased when combined with Clozapine.
CobicistatThe serum concentration of Timolol can be increased when it is combined with Cobicistat.
CocaineThe metabolism of Timolol can be decreased when combined with Cocaine.
ColchicineThe serum concentration of Timolol can be increased when it is combined with Colchicine.
ColforsinThe serum concentration of Timolol can be increased when it is combined with Colforsin.
CoumaphosCoumaphos may increase the bradycardic activities of Timolol.
CrizotinibThe serum concentration of Timolol can be increased when it is combined with Crizotinib.
CrizotinibTimolol may increase the bradycardic activities of Crizotinib.
CryptenamineTimolol may increase the hypotensive activities of Cryptenamine.
CyclophosphamideThe serum concentration of Timolol can be increased when it is combined with Cyclophosphamide.
CyclosporineThe serum concentration of Timolol can be decreased when it is combined with Cyclosporine.
CyclothiazideTimolol may increase the hypotensive activities of Cyclothiazide.
D-LimoneneD-Limonene may decrease the antihypertensive activities of Timolol.
DabrafenibThe serum concentration of Timolol can be decreased when it is combined with Dabrafenib.
DaclatasvirThe serum concentration of Timolol can be increased when it is combined with Daclatasvir.
DactinomycinThe serum concentration of Timolol can be increased when it is combined with Dactinomycin.
DapagliflozinThe risk or severity of adverse effects can be increased when Timolol is combined with Dapagliflozin.
DapoxetineThe serum concentration of Timolol can be increased when it is combined with Dapoxetine.
DarifenacinThe metabolism of Timolol can be decreased when combined with Darifenacin.
DarunavirThe serum concentration of Timolol can be increased when it is combined with Darunavir.
DasatinibThe serum concentration of Timolol can be increased when it is combined with Dasatinib.
DaunorubicinThe serum concentration of Timolol can be decreased when it is combined with Daunorubicin.
DebrisoquinTimolol may increase the hypotensive activities of Debrisoquin.
DecamethoniumDecamethonium may increase the bradycardic activities of Timolol.
DelavirdineThe metabolism of Timolol can be decreased when combined with Delavirdine.
DemecariumDemecarium may increase the bradycardic activities of Timolol.
DeserpidineTimolol may increase the hypotensive activities of Deserpidine.
DesipramineThe serum concentration of Timolol can be increased when it is combined with Desipramine.
DeslanosideTimolol may increase the bradycardic activities of Deslanoside.
DesloratadineThe serum concentration of Timolol can be increased when it is combined with Desloratadine.
DexamethasoneThe serum concentration of Timolol can be decreased when it is combined with Dexamethasone.
DexmedetomidineThe risk or severity of adverse effects can be increased when Timolol is combined with Dexmedetomidine.
DextromethorphanThe serum concentration of Timolol can be increased when it is combined with Dextromethorphan.
DiazoxideDiazoxide may increase the hypotensive activities of Timolol.
DichlorvosDichlorvos may increase the bradycardic activities of Timolol.
DiclofenacDiclofenac may decrease the antihypertensive activities of Timolol.
DiclofenamideThe risk or severity of adverse effects can be increased when Timolol is combined with Diclofenamide.
DiflunisalDiflunisal may decrease the antihypertensive activities of Timolol.
DigitoxinTimolol may increase the bradycardic activities of Digitoxin.
DigoxinTimolol may increase the bradycardic activities of Digoxin.
DigoxinThe serum concentration of Timolol can be decreased when it is combined with Digoxin.
DihydroergotamineTimolol may increase the vasoconstricting activities of Dihydroergotamine.
DihydroergotamineThe serum concentration of Timolol can be increased when it is combined with Dihydroergotamine.
DiltiazemDiltiazem may increase the hypotensive activities of Timolol.
DinutuximabThe risk or severity of adverse effects can be increased when Timolol is combined with Dinutuximab.
DiphenhydramineThe metabolism of Timolol can be decreased when combined with Diphenhydramine.
DipivefrinDipivefrin may increase the atrioventricular blocking (AV block) activities of Timolol.
DipivefrinTimolol may decrease the bronchodilatory activities of Dipivefrin.
DipyridamoleDipyridamole may increase the bradycardic activities of Timolol.
DipyridamoleThe risk or severity of adverse effects can be increased when Timolol is combined with Dipyridamole.
DisopyramideDisopyramide may increase the bradycardic activities of Timolol.
DobutamineTimolol may decrease the bronchodilatory activities of Dobutamine.
DonepezilDonepezil may increase the bradycardic activities of Timolol.
DorzolamideTimolol may increase the hypotensive activities of Dorzolamide.
DoxazosinTimolol may increase the hypotensive activities of Doxazosin.
DoxepinThe serum concentration of Timolol can be increased when it is combined with Doxepin.
DoxorubicinThe serum concentration of Timolol can be decreased when it is combined with Doxorubicin.
DronabinolThe serum concentration of Timolol can be increased when it is combined with Dronabinol.
DronedaroneThe serum concentration of Timolol can be increased when it is combined with Dronedarone.
DronedaroneTimolol may increase the bradycardic activities of Dronedarone.
DroxicamDroxicam may decrease the antihypertensive activities of Timolol.
DroxidopaDroxidopa may increase the atrioventricular blocking (AV block) activities of Timolol.
DroxidopaTimolol may decrease the bronchodilatory activities of Droxidopa.
DuloxetineTimolol may increase the orthostatic hypotensive activities of Duloxetine.
DuloxetineThe metabolism of Timolol can be decreased when combined with Duloxetine.
DyphyllineTimolol may decrease the bronchodilatory activities of Dyphylline.
EchothiophateEchothiophate may increase the bradycardic activities of Timolol.
EdrophoniumEdrophonium may increase the bradycardic activities of Timolol.
EfavirenzThe metabolism of Timolol can be decreased when combined with Efavirenz.
EfonidipineTimolol may increase the hypotensive activities of Efonidipine.
ElbasvirThe serum concentration of Timolol can be increased when it is combined with Elbasvir.
EliglustatThe metabolism of Timolol can be decreased when combined with Eliglustat.
EmpagliflozinThe risk or severity of adverse effects can be increased when Timolol is combined with Empagliflozin.
EnalaprilTimolol may increase the hypotensive activities of Enalapril.
EnalaprilatTimolol may increase the hypotensive activities of Enalaprilat.
EnzalutamideThe serum concentration of Timolol can be increased when it is combined with Enzalutamide.
EphedraEphedra may increase the atrioventricular blocking (AV block) activities of Timolol.
EphedraTimolol may decrease the bronchodilatory activities of Ephedra.
EPIBATIDINEThe risk or severity of adverse effects can be increased when Timolol is combined with EPIBATIDINE.
EpinephrineEpinephrine may increase the atrioventricular blocking (AV block) activities of Timolol.
EpinephrineTimolol may decrease the bronchodilatory activities of Epinephrine.
EpirizoleEpirizole may decrease the antihypertensive activities of Timolol.
EplerenoneThe risk or severity of adverse effects can be increased when Timolol is combined with Eplerenone.
EpoprostenolTimolol may increase the hypotensive activities of Epoprostenol.
EprosartanTimolol may increase the hypotensive activities of Eprosartan.
Ergoloid mesylateTimolol may increase the vasoconstricting activities of Ergoloid mesylate.
ErgonovineTimolol may increase the vasoconstricting activities of Ergonovine.
ErgonovineThe serum concentration of Timolol can be increased when it is combined with Ergonovine.
ErgotamineTimolol may increase the vasoconstricting activities of Ergotamine.
ErgotamineThe serum concentration of Timolol can be increased when it is combined with Ergotamine.
ErythromycinThe serum concentration of Timolol can be decreased when it is combined with Erythromycin.
Eslicarbazepine acetateThe metabolism of Timolol can be decreased when combined with Eslicarbazepine acetate.
EsmololThe risk or severity of adverse effects can be increased when Esmolol is combined with Timolol.
EsomeprazoleThe metabolism of Timolol can be decreased when combined with Esomeprazole.
EstramustineThe serum concentration of Timolol can be increased when it is combined with Estramustine.
EstriolThe serum concentration of Timolol can be decreased when it is combined with Estriol.
EstroneThe serum concentration of Timolol can be decreased when it is combined with Estrone.
Etacrynic acidThe risk or severity of adverse effects can be increased when Timolol is combined with Etacrynic acid.
EtanerceptEtanercept may decrease the antihypertensive activities of Timolol.
EtodolacEtodolac may decrease the antihypertensive activities of Timolol.
EtofenamateEtofenamate may decrease the antihypertensive activities of Timolol.
EtomidateEtomidate may increase the atrioventricular blocking (AV block) activities of Timolol.
EtoperidoneThe serum concentration of Timolol can be increased when it is combined with Etoperidone.
EtoposideThe serum concentration of Timolol can be increased when it is combined with Etoposide.
EtoricoxibEtoricoxib may decrease the antihypertensive activities of Timolol.
EtravirineThe serum concentration of Timolol can be increased when it is combined with Etravirine.
Evening primrose oilEvening primrose oil may decrease the antihypertensive activities of Timolol.
exisulindexisulind may decrease the antihypertensive activities of Timolol.
FelodipineTimolol may increase the hypotensive activities of Felodipine.
FenbufenFenbufen may decrease the antihypertensive activities of Timolol.
FenfluramineThe serum concentration of Timolol can be increased when it is combined with Fenfluramine.
FenoldopamTimolol may increase the hypotensive activities of Fenoldopam.
FenoprofenFenoprofen may decrease the antihypertensive activities of Timolol.
FenoterolTimolol may decrease the bronchodilatory activities of Fenoterol.
FentanylThe serum concentration of Timolol can be increased when it is combined with Fentanyl.
FenthionFenthion may increase the bradycardic activities of Timolol.
FexofenadineThe serum concentration of Timolol can be increased when it is combined with Fexofenadine.
FidaxomicinThe serum concentration of Timolol can be increased when it is combined with Fidaxomicin.
FingolimodTimolol may increase the bradycardic activities of Fingolimod.
FloctafenineThe risk or severity of adverse effects can be increased when Floctafenine is combined with Timolol.
FluconazoleThe serum concentration of Timolol can be increased when it is combined with Fluconazole.
FlunixinFlunixin may decrease the antihypertensive activities of Timolol.
FluoxetineThe serum concentration of Timolol can be increased when it is combined with Fluoxetine.
FlupentixolThe serum concentration of Timolol can be increased when it is combined with Flupentixol.
FluphenazineFluphenazine may increase the hypotensive activities of Timolol.
FlurazepamThe serum concentration of Timolol can be increased when it is combined with Flurazepam.
FlurbiprofenFlurbiprofen may decrease the antihypertensive activities of Timolol.
FluvoxamineThe serum concentration of Timolol can be increased when it is combined with Fluvoxamine.
FormoterolTimolol may decrease the bronchodilatory activities of Formoterol.
FosinoprilTimolol may increase the hypotensive activities of Fosinopril.
FosphenytoinThe metabolism of Timolol can be increased when combined with Fosphenytoin.
FurazolidoneFurazolidone may increase the hypotensive activities of Timolol.
FurosemideThe risk or severity of adverse effects can be increased when Timolol is combined with Furosemide.
GalantamineGalantamine may increase the bradycardic activities of Timolol.
Gallamine TriethiodideGallamine Triethiodide may increase the bradycardic activities of Timolol.
GefitinibThe serum concentration of Timolol can be increased when it is combined with Gefitinib.
GemfibrozilThe metabolism of Timolol can be decreased when combined with Gemfibrozil.
GenisteinThe serum concentration of Timolol can be increased when it is combined with Genistein.
Ginkgo bilobaGinkgo biloba may increase the bradycardic activities of Timolol.
GlibornurideTimolol may increase the hypoglycemic activities of Glibornuride.
GliclazideTimolol may increase the hypoglycemic activities of Gliclazide.
GlimepirideTimolol may increase the hypoglycemic activities of Glimepiride.
GlipizideTimolol may increase the hypoglycemic activities of Glipizide.
GliquidoneTimolol may increase the hypoglycemic activities of Gliquidone.
GlisoxepideTimolol may increase the hypoglycemic activities of Glisoxepide.
GlyburideTimolol may increase the hypoglycemic activities of Glyburide.
GlyburideThe serum concentration of Timolol can be increased when it is combined with Glyburide.
GlycerolThe serum concentration of Timolol can be increased when it is combined with Glycerol.
Gramicidin DThe serum concentration of Timolol can be increased when it is combined with Gramicidin D.
GrepafloxacinThe serum concentration of Timolol can be increased when it is combined with Grepafloxacin.
GTS-21The risk or severity of adverse effects can be increased when Timolol is combined with GTS-21.
GuanabenzTimolol may increase the hypotensive activities of Guanabenz.
GuanadrelGuanadrel may increase the hypotensive activities of Timolol.
GuanethidineTimolol may increase the hypotensive activities of Guanethidine.
GuanfacineTimolol may increase the hypotensive activities of Guanfacine.
HaloperidolThe serum concentration of Timolol can be increased when it is combined with Haloperidol.
HexamethoniumTimolol may increase the hypotensive activities of Hexamethonium.
HexobarbitalHexobarbital may increase the hypotensive activities of Timolol.
HMPL-004HMPL-004 may decrease the antihypertensive activities of Timolol.
Huperzine AHuperzine A may increase the bradycardic activities of Timolol.
HydracarbazineHydracarbazine may increase the hypotensive activities of Timolol.
HydralazineTimolol may increase the hypotensive activities of Hydralazine.
HydrochlorothiazideTimolol may increase the hypotensive activities of Hydrochlorothiazide.
HydrocortisoneThe serum concentration of Timolol can be increased when it is combined with Hydrocortisone.
HydroflumethiazideTimolol may increase the hypotensive activities of Hydroflumethiazide.
HydroxychloroquineThe metabolism of Timolol can be decreased when combined with Hydroxychloroquine.
IbuprofenIbuprofen may decrease the antihypertensive activities of Timolol.
IbuproxamIbuproxam may decrease the antihypertensive activities of Timolol.
IcatibantIcatibant may decrease the antihypertensive activities of Timolol.
IdelalisibThe serum concentration of Timolol can be increased when it is combined with Idelalisib.
IloprostIloprost may increase the hypotensive activities of Timolol.
ImatinibThe serum concentration of Timolol can be increased when it is combined with Imatinib.
ImipramineThe serum concentration of Timolol can be increased when it is combined with Imipramine.
IndacaterolTimolol may decrease the bronchodilatory activities of Indacaterol.
IndalpineThe serum concentration of Timolol can be increased when it is combined with Indalpine.
IndapamideTimolol may increase the hypotensive activities of Indapamide.
IndenololTimolol may increase the hypotensive activities of Indenolol.
IndinavirThe serum concentration of Timolol can be decreased when it is combined with Indinavir.
IndomethacinIndomethacin may decrease the antihypertensive activities of Timolol.
IndoprofenIndoprofen may decrease the antihypertensive activities of Timolol.
IndoraminTimolol may increase the hypotensive activities of Indoramin.
Insulin PorkTimolol may increase the hypoglycemic activities of Insulin Pork.
IproclozideIproclozide may increase the hypotensive activities of Timolol.
IproniazidIproniazid may increase the hypotensive activities of Timolol.
IrbesartanTimolol may increase the hypotensive activities of Irbesartan.
IsavuconazoniumThe serum concentration of Timolol can be increased when it is combined with Isavuconazonium.
IsocarboxazidIsocarboxazid may increase the hypotensive activities of Timolol.
IsoetarineTimolol may decrease the bronchodilatory activities of Isoetarine.
IsoflurophateIsoflurophate may increase the bradycardic activities of Timolol.
IsoniazidThe metabolism of Timolol can be decreased when combined with Isoniazid.
IsoprenalineTimolol may decrease the bronchodilatory activities of Isoprenaline.
Isosorbide DinitrateThe risk or severity of adverse effects can be increased when Timolol is combined with Isosorbide Dinitrate.
Isosorbide MononitrateThe risk or severity of adverse effects can be increased when Timolol is combined with Isosorbide Mononitrate.
IsoxicamIsoxicam may decrease the antihypertensive activities of Timolol.
IsoxsuprineThe risk or severity of adverse effects can be increased when Timolol is combined with Isoxsuprine.
IsradipineIsradipine may increase the hypotensive activities of Timolol.
ItraconazoleThe serum concentration of Timolol can be increased when it is combined with Itraconazole.
IvabradineTimolol may increase the bradycardic activities of Ivabradine.
IvacaftorThe serum concentration of Timolol can be increased when it is combined with Ivacaftor.
IvermectinThe serum concentration of Timolol can be increased when it is combined with Ivermectin.
KebuzoneKebuzone may decrease the antihypertensive activities of Timolol.
KetamineThe serum concentration of Timolol can be increased when it is combined with Ketamine.
KetoconazoleThe serum concentration of Timolol can be increased when it is combined with Ketoconazole.
KetoprofenKetoprofen may decrease the antihypertensive activities of Timolol.
KetorolacKetorolac may decrease the antihypertensive activities of Timolol.
LabetalolTimolol may increase the hypotensive activities of Labetalol.
LacidipineTimolol may increase the hypotensive activities of Lacidipine.
LacosamideTimolol may increase the atrioventricular blocking (AV block) activities of Lacosamide.
LanreotideTimolol may increase the bradycardic activities of Lanreotide.
LansoprazoleThe serum concentration of Timolol can be increased when it is combined with Lansoprazole.
LapatinibThe serum concentration of Timolol can be increased when it is combined with Lapatinib.
LatanoprostTimolol may increase the hypotensive activities of Latanoprost.
LeflunomideLeflunomide may decrease the antihypertensive activities of Timolol.
LercanidipineTimolol may increase the hypotensive activities of Lercanidipine.
LevobunololThe risk or severity of adverse effects can be increased when Timolol is combined with Levobunolol.
LevodopaTimolol may increase the orthostatic hypotensive activities of Levodopa.
LevofloxacinThe serum concentration of Timolol can be increased when it is combined with Levofloxacin.
LevomilnacipranThe serum concentration of Timolol can be increased when it is combined with Levomilnacipran.
LevothyroxineThe serum concentration of Timolol can be decreased when it is combined with Levothyroxine.
LidocaineThe serum concentration of Lidocaine can be increased when it is combined with Timolol.
LiothyronineThe serum concentration of Timolol can be decreased when it is combined with Liothyronine.
LiotrixThe serum concentration of Timolol can be decreased when it is combined with Liotrix.
LisinoprilTimolol may increase the hypotensive activities of Lisinopril.
LobelineThe risk or severity of adverse effects can be increased when Timolol is combined with Lobeline.
LofexidineTimolol may increase the hypotensive activities of Lofexidine.
LomitapideThe serum concentration of Timolol can be increased when it is combined with Lomitapide.
LoperamideThe serum concentration of Timolol can be increased when it is combined with Loperamide.
LopinavirThe serum concentration of Timolol can be increased when it is combined with Lopinavir.
LoratadineThe serum concentration of Timolol can be increased when it is combined with Loratadine.
LorcaserinThe metabolism of Timolol can be decreased when combined with Lorcaserin.
LornoxicamLornoxicam may decrease the antihypertensive activities of Timolol.
LosartanTimolol may increase the hypotensive activities of Losartan.
LovastatinThe serum concentration of Timolol can be increased when it is combined with Lovastatin.
LoxoprofenLoxoprofen may decrease the antihypertensive activities of Timolol.
Lu AA21004The serum concentration of Timolol can be increased when it is combined with Lu AA21004.
LucinactantTimolol may increase the bradycardic activities of Lucinactant.
LuliconazoleThe serum concentration of Timolol can be increased when it is combined with Luliconazole.
LumacaftorThe serum concentration of Timolol can be decreased when it is combined with Lumacaftor.
LumefantrineThe metabolism of Timolol can be decreased when combined with Lumefantrine.
LumiracoxibLumiracoxib may decrease the antihypertensive activities of Timolol.
MacitentanTimolol may increase the hypotensive activities of Macitentan.
Magnesium salicylateMagnesium salicylate may decrease the antihypertensive activities of Timolol.
MalathionMalathion may increase the bradycardic activities of Timolol.
ManidipineTimolol may increase the hypotensive activities of Manidipine.
MannitolThe risk or severity of adverse effects can be increased when Timolol is combined with Mannitol.
MaprotilineThe serum concentration of Timolol can be increased when it is combined with Maprotiline.
MasoprocolMasoprocol may decrease the antihypertensive activities of Timolol.
MebanazineMebanazine may increase the hypotensive activities of Timolol.
MebendazoleThe serum concentration of Timolol can be increased when it is combined with Mebendazole.
MecamylamineTimolol may increase the hypotensive activities of Mecamylamine.
Meclofenamic acidMeclofenamic acid may decrease the antihypertensive activities of Timolol.
Mefenamic acidMefenamic acid may decrease the antihypertensive activities of Timolol.
MefloquineMefloquine may increase the bradycardic activities of Timolol.
Megestrol acetateThe serum concentration of Timolol can be increased when it is combined with Megestrol acetate.
MeloxicamMeloxicam may decrease the antihypertensive activities of Timolol.
MemantineMemantine may increase the bradycardic activities of Timolol.
MepivacaineThe serum concentration of Mepivacaine can be increased when it is combined with Timolol.
MeprobamateThe serum concentration of Timolol can be increased when it is combined with Meprobamate.
MesalazineMesalazine may decrease the antihypertensive activities of Timolol.
MesoridazineMesoridazine may increase the hypotensive activities of Timolol.
MetamizoleMetamizole may decrease the antihypertensive activities of Timolol.
MethacholineThe risk or severity of adverse effects can be increased when Timolol is combined with Methacholine.
MethadoneThe serum concentration of Timolol can be increased when it is combined with Methadone.
MethamphetamineMethamphetamine may increase the atrioventricular blocking (AV block) activities of Timolol.
MethazolamideThe risk or severity of adverse effects can be increased when Timolol is combined with Methazolamide.
MethohexitalMethohexital may increase the hypotensive activities of Timolol.
MethotrimeprazineMethotrimeprazine may increase the hypotensive activities of Timolol.
MethyclothiazideThe risk or severity of adverse effects can be increased when Methyclothiazide is combined with Timolol.
MethyldopaTimolol may increase the hypotensive activities of Methyldopa.
Methylene blueMethylene blue may increase the hypotensive activities of Timolol.
MethylphenidateMethylphenidate may decrease the antihypertensive activities of Timolol.
MethylphenobarbitalMethylphenobarbital may increase the hypotensive activities of Timolol.
MetipranololTimolol may increase the hypotensive activities of Metipranolol.
MetolazoneTimolol may increase the hypotensive activities of Metolazone.
MetoprololMetoprolol may increase the hypotensive activities of Timolol.
MibefradilTimolol may increase the hypotensive activities of Mibefradil.
MiconazoleThe serum concentration of Timolol can be increased when it is combined with Miconazole.
MidazolamThe serum concentration of Timolol can be decreased when it is combined with Midazolam.
MidodrineTimolol may increase the bradycardic activities of Midodrine.
MifepristoneThe serum concentration of Timolol can be decreased when it is combined with Mifepristone.
MilnacipranThe serum concentration of Timolol can be increased when it is combined with Milnacipran.
MinaprineMinaprine may increase the bradycardic activities of Timolol.
MinoxidilMinoxidil may increase the hypotensive activities of Timolol.
MirabegronThe metabolism of Timolol can be decreased when combined with Mirabegron.
MitomycinThe serum concentration of Timolol can be increased when it is combined with Mitomycin.
MitoxantroneThe serum concentration of Timolol can be decreased when it is combined with Mitoxantrone.
MoclobemideMoclobemide may increase the hypotensive activities of Timolol.
ModafinilThe metabolism of Timolol can be decreased when combined with Modafinil.
MoexiprilTimolol may increase the hypotensive activities of Moexipril.
MolsidomineMolsidomine may increase the hypotensive activities of Timolol.
MoricizineMoricizine may increase the hypotensive activities of Timolol.
MorphineThe serum concentration of Timolol can be increased when it is combined with Morphine.
MoxonidineTimolol may increase the hypotensive activities of Moxonidine.
Mycophenolate mofetilMycophenolate mofetil may decrease the antihypertensive activities of Timolol.
Mycophenolic acidMycophenolic acid may decrease the antihypertensive activities of Timolol.
NabumetoneNabumetone may decrease the antihypertensive activities of Timolol.
NadololTimolol may increase the hypotensive activities of Nadolol.
NaftifineNaftifine may decrease the antihypertensive activities of Timolol.
NaltrexoneThe serum concentration of Timolol can be increased when it is combined with Naltrexone.
NaphazolineNaphazoline may increase the atrioventricular blocking (AV block) activities of Timolol.
NaproxenNaproxen may decrease the antihypertensive activities of Timolol.
NaringeninThe serum concentration of Timolol can be increased when it is combined with Naringenin.
NCX 4016NCX 4016 may decrease the antihypertensive activities of Timolol.
NebivololTimolol may increase the hypotensive activities of Nebivolol.
NefazodoneThe serum concentration of Timolol can be decreased when it is combined with Nefazodone.
NelfinavirThe serum concentration of Timolol can be decreased when it is combined with Nelfinavir.
NeostigmineNeostigmine may increase the bradycardic activities of Timolol.
NepafenacNepafenac may decrease the antihypertensive activities of Timolol.
NesiritideThe risk or severity of adverse effects can be increased when Timolol is combined with Nesiritide.
NevirapineThe metabolism of Timolol can be decreased when combined with Nevirapine.
NialamideNialamide may increase the hypotensive activities of Timolol.
NicardipineTimolol may increase the hypotensive activities of Nicardipine.
NicorandilNicorandil may increase the hypotensive activities of Timolol.
NicotineThe risk or severity of adverse effects can be increased when Timolol is combined with Nicotine.
Nicotine bitartrateThe risk or severity of adverse effects can be increased when Timolol is combined with Nicotine bitartrate.
NifedipineNifedipine may increase the hypotensive activities of Timolol.
NifedipineThe risk or severity of adverse effects can be increased when Timolol is combined with Nifedipine.
Niflumic AcidNiflumic Acid may decrease the antihypertensive activities of Timolol.
NiguldipineTimolol may increase the hypotensive activities of Niguldipine.
NilotinibThe serum concentration of Timolol can be increased when it is combined with Nilotinib.
NilvadipineTimolol may increase the hypotensive activities of Nilvadipine.
NimesulideNimesulide may decrease the antihypertensive activities of Timolol.
NimodipineTimolol may increase the hypotensive activities of Nimodipine.
NisoldipineTimolol may increase the hypotensive activities of Nisoldipine.
NitrazepamThe serum concentration of Timolol can be increased when it is combined with Nitrazepam.
NitrendipineTimolol may increase the hypotensive activities of Nitrendipine.
NitroglycerinThe risk or severity of adverse effects can be increased when Timolol is combined with Nitroglycerin.
NitroprussideNitroprusside may increase the hypotensive activities of Timolol.
NorepinephrineNorepinephrine may increase the atrioventricular blocking (AV block) activities of Timolol.
NorepinephrineTimolol may decrease the bronchodilatory activities of Norepinephrine.
NorethisteroneThe serum concentration of Timolol can be decreased when it is combined with Norethisterone.
ObinutuzumabTimolol may increase the hypotensive activities of Obinutuzumab.
OctamoxinOctamoxin may increase the hypotensive activities of Timolol.
OctreotideOctreotide may increase the bradycardic activities of Timolol.
OlanzapineThe serum concentration of Timolol can be increased when it is combined with Olanzapine.
OlmesartanOlmesartan may increase the hypotensive activities of Timolol.
OlodaterolTimolol may decrease the bronchodilatory activities of Olodaterol.
OlopatadineOlopatadine may decrease the antihypertensive activities of Timolol.
OlsalazineOlsalazine may decrease the antihypertensive activities of Timolol.
OmapatrilatTimolol may increase the hypotensive activities of Omapatrilat.
OmeprazoleThe serum concentration of Timolol can be increased when it is combined with Omeprazole.
OrciprenalineTimolol may decrease the bronchodilatory activities of Orciprenaline.
OrgoteinOrgotein may decrease the antihypertensive activities of Timolol.
OuabainTimolol may increase the bradycardic activities of Ouabain.
OxaprozinOxaprozin may decrease the antihypertensive activities of Timolol.
OxprenololTimolol may increase the hypotensive activities of Oxprenolol.
OxymetazolineOxymetazoline may increase the atrioventricular blocking (AV block) activities of Timolol.
OxyphenbutazoneOxyphenbutazone may decrease the antihypertensive activities of Timolol.
P-NitrophenolThe serum concentration of Timolol can be increased when it is combined with P-Nitrophenol.
PaclitaxelThe serum concentration of Timolol can be increased when it is combined with Paclitaxel.
PaliperidonePaliperidone may increase the atrioventricular blocking (AV block) activities of Timolol.
Palmitic AcidThe serum concentration of Timolol can be increased when it is combined with Palmitic Acid.
PanobinostatThe metabolism of Timolol can be decreased when combined with Panobinostat.
PantoprazoleThe serum concentration of Timolol can be increased when it is combined with Pantoprazole.
PapaverineThe risk or severity of adverse effects can be increased when Timolol is combined with Papaverine.
ParecoxibParecoxib may decrease the antihypertensive activities of Timolol.
PargylineTimolol may increase the hypotensive activities of Pargyline.
ParoxetineThe serum concentration of Timolol can be increased when it is combined with Paroxetine.
PasireotideTimolol may increase the bradycardic activities of Pasireotide.
Peginterferon alfa-2bThe serum concentration of Timolol can be decreased when it is combined with Peginterferon alfa-2b.
PenbutololTimolol may increase the hypotensive activities of Penbutolol.
PentobarbitalPentobarbital may increase the hypotensive activities of Timolol.
PentoliniumTimolol may increase the hypotensive activities of Pentolinium.
PentoxifyllinePentoxifylline may increase the hypotensive activities of Timolol.
PergolidePergolide may increase the atrioventricular blocking (AV block) activities of Timolol.
PerindoprilTimolol may increase the hypotensive activities of Perindopril.
PerphenazinePerphenazine may increase the hypotensive activities of Timolol.
PhenelzinePhenelzine may increase the hypotensive activities of Timolol.
PheniprazinePheniprazine may increase the hypotensive activities of Timolol.
PhenobarbitalPhenobarbital may increase the hypotensive activities of Timolol.
PhenoxybenzamineTimolol may increase the hypotensive activities of Phenoxybenzamine.
PhenoxypropazinePhenoxypropazine may increase the hypotensive activities of Timolol.
PhentolamineTimolol may increase the hypotensive activities of Phentolamine.
PhenylbutazonePhenylbutazone may decrease the antihypertensive activities of Timolol.
PhenylpropanolaminePhenylpropanolamine may increase the atrioventricular blocking (AV block) activities of Timolol.
PhenylpropanolamineTimolol may decrease the bronchodilatory activities of Phenylpropanolamine.
PhenytoinThe metabolism of Timolol can be increased when combined with Phenytoin.
PhysostigminePhysostigmine may increase the bradycardic activities of Timolol.
PilocarpineThe risk or severity of adverse effects can be increased when Timolol is combined with Pilocarpine.
PimecrolimusPimecrolimus may decrease the antihypertensive activities of Timolol.
PimozideThe serum concentration of Timolol can be increased when it is combined with Pimozide.
PinacidilTimolol may increase the hypotensive activities of Pinacidil.
PindololTimolol may increase the hypotensive activities of Pindolol.
PirbuterolTimolol may decrease the bronchodilatory activities of Pirbuterol.
PirfenidonePirfenidone may decrease the antihypertensive activities of Timolol.
PirlindolePirlindole may increase the hypotensive activities of Timolol.
PiroxicamPiroxicam may decrease the antihypertensive activities of Timolol.
PivhydrazinePivhydrazine may increase the hypotensive activities of Timolol.
Platelet Activating FactorThe serum concentration of Timolol can be decreased when it is combined with Platelet Activating Factor.
PolythiazideTimolol may increase the hypotensive activities of Polythiazide.
PonatinibThe serum concentration of Timolol can be increased when it is combined with Ponatinib.
Poractant alfaTimolol may increase the bradycardic activities of Poractant alfa.
PosaconazoleThe serum concentration of Timolol can be increased when it is combined with Posaconazole.
PravastatinThe serum concentration of Timolol can be increased when it is combined with Pravastatin.
PrazosinTimolol may increase the hypotensive activities of Prazosin.
PrednisoneThe serum concentration of Timolol can be increased when it is combined with Prednisone.
PrimaquineThe metabolism of Timolol can be decreased when combined with Primaquine.
PrimidonePrimidone may increase the hypotensive activities of Timolol.
ProbenecidThe serum concentration of Timolol can be increased when it is combined with Probenecid.
ProcaterolTimolol may decrease the bronchodilatory activities of Procaterol.
ProchlorperazineProchlorperazine may increase the hypotensive activities of Timolol.
ProgesteroneThe serum concentration of Timolol can be decreased when it is combined with Progesterone.
PromazinePromazine may increase the hypotensive activities of Timolol.
PromethazinePromethazine may increase the hypotensive activities of Timolol.
PropacetamolPropacetamol may decrease the antihypertensive activities of Timolol.
PropafenoneThe serum concentration of Timolol can be increased when it is combined with Propafenone.
PropafenoneTimolol may increase the bradycardic activities of Propafenone.
PropranololTimolol may increase the hypotensive activities of Propranolol.
ProtriptylineThe serum concentration of Timolol can be increased when it is combined with Protriptyline.
PseudoephedrinePseudoephedrine may increase the atrioventricular blocking (AV block) activities of Timolol.
PTC299PTC299 may decrease the antihypertensive activities of Timolol.
PyridostigminePyridostigmine may increase the bradycardic activities of Timolol.
QuercetinThe serum concentration of Timolol can be increased when it is combined with Quercetin.
QuetiapineThe risk or severity of adverse effects can be increased when Timolol is combined with Quetiapine.
QuinacrineThe serum concentration of Timolol can be increased when it is combined with Quinacrine.
QuinaprilTimolol may increase the hypotensive activities of Quinapril.
QuinidineThe serum concentration of Timolol can be increased when it is combined with Quinidine.
QuinineQuinine may increase the hypotensive activities of Timolol.
RamiprilRamipril may increase the hypotensive activities of Timolol.
RanitidineThe serum concentration of Timolol can be increased when it is combined with Ranitidine.
RanolazineThe serum concentration of Timolol can be increased when it is combined with Ranolazine.
RasagilineRasagiline may increase the hypotensive activities of Timolol.
ReboxetineThe serum concentration of Timolol can be increased when it is combined with Reboxetine.
RegorafenibRegorafenib may increase the bradycardic activities of Timolol.
RemikirenRemikiren may increase the hypotensive activities of Timolol.
RescinnamineTimolol may increase the hypotensive activities of Rescinnamine.
ReserpineReserpine may increase the hypotensive activities of Timolol.
ResveratrolResveratrol may decrease the antihypertensive activities of Timolol.
RifampicinThe serum concentration of Timolol can be decreased when it is combined with Rifampicin.
RilpivirineThe serum concentration of Timolol can be increased when it is combined with Rilpivirine.
RiociguatTimolol may increase the hypotensive activities of Riociguat.
RisperidoneTimolol may increase the hypotensive activities of Risperidone.
RisperidoneRisperidone may increase the atrioventricular blocking (AV block) activities of Timolol.
RitodrineTimolol may decrease the bronchodilatory activities of Ritodrine.
RitonavirThe serum concentration of Timolol can be decreased when it is combined with Ritonavir.
RituximabTimolol may increase the hypotensive activities of Rituximab.
RivastigmineRivastigmine may increase the bradycardic activities of Timolol.
RofecoxibRofecoxib may decrease the antihypertensive activities of Timolol.
RolapitantThe serum concentration of Timolol can be increased when it is combined with Rolapitant.
RopiniroleThe metabolism of Timolol can be decreased when combined with Ropinirole.
RuxolitinibRuxolitinib may increase the bradycardic activities of Timolol.
SafrazineSafrazine may increase the hypotensive activities of Timolol.
SalbutamolTimolol may decrease the bronchodilatory activities of Salbutamol.
SalicylamideSalicylamide may decrease the antihypertensive activities of Timolol.
Salicylic acidSalicylic acid may decrease the antihypertensive activities of Timolol.
SalmeterolTimolol may decrease the bronchodilatory activities of Salmeterol.
SalsalateSalsalate may decrease the antihypertensive activities of Timolol.
SaprisartanTimolol may increase the hypotensive activities of Saprisartan.
SaquinavirThe serum concentration of Timolol can be decreased when it is combined with Saquinavir.
ScopolamineThe serum concentration of Timolol can be increased when it is combined with Scopolamine.
SecobarbitalSecobarbital may increase the hypotensive activities of Timolol.
SelegilineSelegiline may increase the hypotensive activities of Timolol.
SelexipagTimolol may increase the hypotensive activities of Selexipag.
SeratrodastSeratrodast may decrease the antihypertensive activities of Timolol.
SertralineThe serum concentration of Timolol can be increased when it is combined with Sertraline.
SildenafilSildenafil may increase the antihypertensive activities of Timolol.
SilodosinTimolol may increase the orthostatic hypotensive activities of Silodosin.
SimeprevirThe serum concentration of Timolol can be increased when it is combined with Simeprevir.
SimvastatinThe serum concentration of Timolol can be increased when it is combined with Simvastatin.
SirolimusThe serum concentration of Timolol can be decreased when it is combined with Sirolimus.
SitaxentanTimolol may increase the hypotensive activities of Sitaxentan.
SorafenibThe serum concentration of Timolol can be increased when it is combined with Sorafenib.
SotalolThe risk or severity of adverse effects can be increased when Timolol is combined with Sotalol.
SpiraprilTimolol may increase the hypotensive activities of Spirapril.
SpironolactoneThe risk or severity of adverse effects can be increased when Timolol is combined with Spironolactone.
SRT501SRT501 may decrease the antihypertensive activities of Timolol.
St. John's WortThe serum concentration of Timolol can be decreased when it is combined with St. John's Wort.
StaurosporineThe serum concentration of Timolol can be increased when it is combined with Staurosporine.
StiripentolThe metabolism of Timolol can be decreased when combined with Stiripentol.
StreptozocinThe serum concentration of Timolol can be decreased when it is combined with Streptozocin.
SufentanilTimolol may increase the bradycardic activities of Sufentanil.
SulfasalazineSulfasalazine may decrease the antihypertensive activities of Timolol.
SulfinpyrazoneThe serum concentration of Timolol can be increased when it is combined with Sulfinpyrazone.
SulindacSulindac may decrease the antihypertensive activities of Timolol.
SumatriptanThe serum concentration of Timolol can be increased when it is combined with Sumatriptan.
SunitinibThe serum concentration of Timolol can be increased when it is combined with Sunitinib.
SuprofenSuprofen may decrease the antihypertensive activities of Timolol.
TacrineTacrine may increase the bradycardic activities of Timolol.
TacrolimusThe serum concentration of Timolol can be decreased when it is combined with Tacrolimus.
TadalafilTadalafil may increase the antihypertensive activities of Timolol.
TamoxifenThe serum concentration of Timolol can be decreased when it is combined with Tamoxifen.
TamsulosinTimolol may increase the orthostatic hypotensive activities of Tamsulosin.
Taurocholic AcidThe serum concentration of Timolol can be increased when it is combined with Taurocholic Acid.
TelmisartanTimolol may increase the hypotensive activities of Telmisartan.
TemocaprilTimolol may increase the hypotensive activities of Temocapril.
TemsirolimusThe serum concentration of Timolol can be increased when it is combined with Temsirolimus.
TenoxicamTenoxicam may decrease the antihypertensive activities of Timolol.
TepoxalinTepoxalin may decrease the antihypertensive activities of Timolol.
TerazosinThe risk or severity of adverse effects can be increased when Timolol is combined with Terazosin.
TerbinafineThe metabolism of Timolol can be decreased when combined with Terbinafine.
TerbutalineTimolol may decrease the bronchodilatory activities of Terbutaline.
TerfenadineThe serum concentration of Timolol can be increased when it is combined with Terfenadine.
TeriflunomideTeriflunomide may decrease the antihypertensive activities of Timolol.
TerlipressinTimolol may increase the hypotensive activities of Terlipressin.
TesmilifeneThe serum concentration of Timolol can be decreased when it is combined with Tesmilifene.
TestosteroneThe serum concentration of Timolol can be increased when it is combined with Testosterone.
TheophyllineTimolol may decrease the bronchodilatory activities of Theophylline.
ThiamylalThiamylal may increase the hypotensive activities of Timolol.
ThiethylperazineThiethylperazine may increase the hypotensive activities of Timolol.
ThiopentalThiopental may increase the hypotensive activities of Timolol.
ThioridazineThioridazine may increase the hypotensive activities of Timolol.
Tiaprofenic acidTiaprofenic acid may decrease the antihypertensive activities of Timolol.
TiboloneTimolol may increase the hypotensive activities of Tibolone.
TicagrelorThe serum concentration of Timolol can be increased when it is combined with Ticagrelor.
TiclopidineThe metabolism of Timolol can be decreased when combined with Ticlopidine.
TicrynafenTimolol may increase the hypotensive activities of Ticrynafen.
TipranavirThe metabolism of Timolol can be decreased when combined with Tipranavir.
TizanidineThe risk or severity of adverse effects can be increased when Timolol is combined with Tizanidine.
TofacitinibTofacitinib may increase the bradycardic activities of Timolol.
TolazamideTimolol may increase the hypoglycemic activities of Tolazamide.
TolazolineTimolol may increase the hypotensive activities of Tolazoline.
TolbutamideTimolol may increase the hypoglycemic activities of Tolbutamide.
Tolfenamic AcidTolfenamic Acid may decrease the antihypertensive activities of Timolol.
TolmetinTolmetin may decrease the antihypertensive activities of Timolol.
ToloxatoneToloxatone may increase the hypotensive activities of Timolol.
TolvaptanThe serum concentration of Timolol can be increased when it is combined with Tolvaptan.
TopiramateThe metabolism of Timolol can be decreased when combined with Topiramate.
TorasemideTorasemide may increase the hypotensive activities of Timolol.
TrandolaprilTimolol may increase the hypotensive activities of Trandolapril.
TranilastTranilast may decrease the antihypertensive activities of Timolol.
Trans-2-PhenylcyclopropylamineTrans-2-Phenylcyclopropylamine may increase the hypotensive activities of Timolol.
TranylcypromineTranylcypromine may increase the hypotensive activities of Timolol.
TravoprostTravoprost may increase the hypotensive activities of Timolol.
TrazodoneThe serum concentration of Timolol can be increased when it is combined with Trazodone.
TreprostinilTimolol may increase the hypotensive activities of Treprostinil.
TriamtereneThe risk or severity of adverse effects can be increased when Timolol is combined with Triamterene.
TrichlorfonTrichlorfon may increase the bradycardic activities of Timolol.
TrichlormethiazideTimolol may increase the hypotensive activities of Trichlormethiazide.
TrifluoperazineTrifluoperazine may increase the hypotensive activities of Timolol.
TriflupromazineTriflupromazine may increase the hypotensive activities of Timolol.
TrimazosinTimolol may increase the hypotensive activities of Trimazosin.
TrimethaphanTimolol may increase the hypotensive activities of Trimethaphan.
TrimethoprimThe serum concentration of Timolol can be decreased when it is combined with Trimethoprim.
TrimipramineThe serum concentration of Timolol can be increased when it is combined with Trimipramine.
Trisalicylate-cholineTrisalicylate-choline may decrease the antihypertensive activities of Timolol.
TroleandomycinThe serum concentration of Timolol can be increased when it is combined with Troleandomycin.
TubocurarineTubocurarine may increase the bradycardic activities of Timolol.
UdenafilUdenafil may increase the antihypertensive activities of Timolol.
UnoprostoneTimolol may increase the hypotensive activities of Unoprostone.
ValdecoxibValdecoxib may decrease the antihypertensive activities of Timolol.
ValsartanValsartan may increase the hypotensive activities of Timolol.
VardenafilVardenafil may increase the antihypertensive activities of Timolol.
VareniclineThe risk or severity of adverse effects can be increased when Timolol is combined with Varenicline.
VenlafaxineThe serum concentration of Timolol can be increased when it is combined with Venlafaxine.
VerapamilThe risk or severity of adverse effects can be increased when Timolol is combined with Verapamil.
VilanterolTimolol may decrease the bronchodilatory activities of Vilanterol.
VilazodoneThe serum concentration of Timolol can be increased when it is combined with Vilazodone.
VinblastineThe serum concentration of Timolol can be decreased when it is combined with Vinblastine.
VincristineThe serum concentration of Timolol can be decreased when it is combined with Vincristine.
VinorelbineThe serum concentration of Timolol can be increased when it is combined with Vinorelbine.
VoriconazoleThe metabolism of Timolol can be decreased when combined with Voriconazole.
VortioxetineThe serum concentration of Timolol can be increased when it is combined with Vortioxetine.
XylometazolineTimolol may increase the hypotensive activities of Xylometazoline.
YohimbineYohimbine may decrease the antihypertensive activities of Timolol.
ZaltoprofenZaltoprofen may decrease the antihypertensive activities of Timolol.
ZileutonZileuton may decrease the antihypertensive activities of Timolol.
ZimelidineThe serum concentration of Timolol can be increased when it is combined with Zimelidine.
ZiprasidoneThe metabolism of Timolol can be decreased when combined with Ziprasidone.
ZomepiracZomepirac may decrease the antihypertensive activities of Timolol.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Receptor signaling protein activity
Specific Function:
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling.
Gene Name:
ADRB1
Uniprot ID:
P08588
Molecular Weight:
51322.1 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  2. Nieminen T, Uusitalo H, Maenpaa J, Turjanmaa V, Rane A, Lundgren S, Ropo A, Rontu R, Lehtimaki T, Kahonen M: Polymorphisms of genes CYP2D6, ADRB1 and GNAS1 in pharmacokinetics and systemic effects of ophthalmic timolol. A pilot study. Eur J Clin Pharmacol. 2005 Dec;61(11):811-9. Epub 2005 Nov 17. [PubMed:16315032 ]
  3. Varma DR, Shen H, Deng XF, Peri KG, Chemtob S, Mulay S: Inverse agonist activities of beta-adrenoceptor antagonists in rat myocardium. Br J Pharmacol. 1999 Jun;127(4):895-902. [PubMed:10433496 ]
  4. Hirooka K, Kelly ME, Baldridge WH, Barnes S: Suppressive actions of betaxolol on ionic currents in retinal ganglion cells may explain its neuroprotective effects. Exp Eye Res. 2000 May;70(5):611-21. [PubMed:10870519 ]
  5. Bhattacharyya BJ, Lee E, Krupin D, Hockberger P, Krupin T: (-)-Isoproterenol modulation of maxi-K(+) channel in nonpigmented ciliary epithelial cells through a G-protein gated pathway. Curr Eye Res. 2002 Mar;24(3):173-81. [PubMed:12221524 ]
  6. Wang T, Kaumann AJ, Brown MJ: (--)-Timolol is a more potent antagonist of the positive inotropic effects of (--)-adrenaline than of those of (--)-noradrenaline in human atrium. Br J Clin Pharmacol. 1996 Aug;42(2):217-23. [PubMed:8864321 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Protein homodimerization activity
Specific Function:
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
Gene Name:
ADRB2
Uniprot ID:
P07550
Molecular Weight:
46458.32 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  2. Fuchsjager-Mayrl G, Markovic O, Losert D, Lucas T, Wachek V, Muller M, Schmetterer L: Polymorphism of the beta-2 adrenoceptor and IOP lowering potency of topical timolol in healthy subjects. Mol Vis. 2005 Sep 23;11:811-5. [PubMed:16205624 ]
  3. Rotmensch HH, Vlasses PH, Feinberg JA, Abrams WB, Ferguson RK: Comparisons of beta-adrenergic blocking properties of S- and R-timolol in humans. J Clin Pharmacol. 1993 Jun;33(6):544-8. [PubMed:8103526 ]
  4. Borger P, Hoekstra Y, Esselink MT, Postma DS, Zaagsma J, Vellenga E, Kauffman HF: Beta-adrenoceptor-mediated inhibition of IFN-gamma, IL-3, and GM-CSF mRNA accumulation in activated human T lymphocytes is solely mediated by the beta2-adrenoceptor subtype. Am J Respir Cell Mol Biol. 1998 Sep;19(3):400-7. [PubMed:9730867 ]
  5. Van der Graaf PH, Saxena PR, Shankley NP, Black JW: Exposure and characterization of the action of noradrenaline at dopamine receptors mediating endothelium-independent relaxation of rat isolated small mesenteric arteries. Br J Pharmacol. 1995 Dec;116(8):3237-42. [PubMed:8719802 ]
  6. Ferro A, Hall JA, Dickerson JE, Brown MJ: A prospective study of the effects of prolonged timolol therapy on alpha- and beta-adrenoceptor and angiotensin II receptor mediated responses in normal subjects. Br J Clin Pharmacol. 1997 Mar;43(3):301-8. [PubMed:9088585 ]
  7. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Enterobacteria phage T4
Pharmacological action
unknown
General Function:
Lysozyme activity
Specific Function:
Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.
Gene Name:
E
Uniprot ID:
P00720
Molecular Weight:
18691.385 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Terao T, Hisanaga E, Sai Y, Tamai I, Tsuji A: Active secretion of drugs from the small intestinal epithelium in rats by P-glycoprotein functioning as an absorption barrier. J Pharm Pharmacol. 1996 Oct;48(10):1083-9. [PubMed:8953513 ]
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Drug created on June 13, 2005 07:24 / Updated on September 26, 2016 03:28