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Identification
NamePhenylpropanolamine
Accession NumberDB00397  (APRD00457)
Typesmall molecule
Groupsapproved, withdrawn
Description

Phenylpropanolamine has been withdrawn in Canada and the United States. In November 2000, the Food and Drug Administration (FDA) issued a public health advisory against the use of the drug.

Structure
Thumb
Synonyms
SynonymLanguageCode
2-amino-1-phenylpropan-1-olNot AvailableIUPAC
FenilpropanolaminaSpanishINN
NorephedrinNot AvailableWHO
NorephedrineNot AvailableNot Available
PhenylpropanolaminGermanINN
PhénylpropanolamineFrenchINN
PhenylpropanolaminumLatinINN
PPANot AvailableNot Available
β-hydroxyamphetamine)Not AvailableNot Available
Salts
Name/CAS Structure Properties
Phenylpropanolamine hydrochloride
Thumb Not applicable DBSALT000996
Brand names
NameCompany
AcutrimNot Available
BoxogettenCheplapharm
DexatrimNot Available
DisudrinPediatrica
NaldecIAE
NasadecMedlink
NasatheraMorishita-Seggs
PropagestNot Available
Recatol monoRiemser
RhindeconNot Available
RinexinMeda
Brand mixtures
Brand NameIngredients
Alka Seltzer Plus Cold Medicine EvtAcetylsalicylic Acid + Chlorpheniramine Maleate + Phenylpropanolamine Bitartrate
Bronchodex D CapChlorpheniramine Maleate + Pheniramine Maleate + Phenylpropanolamine Hydrochloride
Bronchosirum Pour EnfantsDextromethorphan Hydrobromide + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate
Caldomine DHHydrocodone Bitartrate + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate
Centracol DMDextromethorphan Hydrobromide + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate
Chlor Tripolon DecongestChlorpheniramine Maleate + Phenylpropanolamine Hydrochloride
Cold & AllergyBrompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride
Cold & Allergy ReliefBrompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride
Cold Decongestant Long ActingChlorpheniramine Maleate + Pheniramine Maleate + Phenylpropanolamine Hydrochloride
Cold ReliefBrompheniramine Maleate + Phenylpropanolamine Hydrochloride
Cold Relief DMBrompheniramine Maleate + Dextromethorphan Hydrobromide + Phenylpropanolamine Hydrochloride
Coltalin TabletAcetaminophen + Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride
Contac Cold CapsulesChlorpheniramine Maleate + Phenylpropanolamine Hydrochloride
Contac Cold Extra Strength CapsulesChlorpheniramine Maleate + Phenylpropanolamine Hydrochloride
Contac Cough Cold and Flu CapletsAcetaminophen + Chlorpheniramine Maleate + Dextromethorphan Hydrobromide + Phenylpropanolamine Hydrochloride
Contact CChlorpheniramine Maleate + Phenylpropanolamine Hydrochloride
Coricidin DAcetylsalicylic Acid + Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride
Coricidin NDAcetylsalicylic Acid + Phenylpropanolamine Hydrochloride
Coricidin Sinus HeadacheAcetaminophen + Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride
Corsym SuspensionChlorpheniramine Maleate + Phenylpropanolamine Hydrochloride
Cough, Cold & Allergy ReliefBrompheniramine Maleate + Dextromethorphan Hydrobromide + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride
Counteract Sinus and AllergyAcetaminophen + Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride
Decongestant Antihistaminic SyrupBrompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride
DilotabAcetaminophen + Phenylpropanolamine Hydrochloride
Dimetane ExpectorantBrompheniramine Maleate + Guaifenesin + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride
Dimetane Expectorant-CBrompheniramine Maleate + Codeine Phosphate + Guaifenesin + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride
Dimetane Expectorant-DCBrompheniramine Maleate + Guaifenesin + Hydrocodone Bitartrate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride
DimetappBrompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride
Dimetapp Chewable TabletsBrompheniramine Maleate + Phenylpropanolamine Hydrochloride
Dimetapp Children's Cold & Allergy TabletsBrompheniramine Maleate + Phenylpropanolamine Hydrochloride
Dimetapp Children's Cold & FeverAcetaminophen + Brompheniramine Maleate + Phenylpropanolamine Hydrochloride
Dimetapp ClearBrompheniramine Maleate + Phenylpropanolamine Hydrochloride
Dimetapp Cold & SinusAcetaminophen + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride
Dimetapp Cough & Cold Liqui-GelsBrompheniramine Maleate + Dextromethorphan Hydrobromide + Phenylpropanolamine Hydrochloride
Dimetapp Cough, Cold & FluAcetaminophen + Brompheniramine Maleate + Dextromethorphan Hydrobromide + Phenylpropanolamine Hydrochloride
Dimetapp DMBrompheniramine Maleate + Dextromethorphan Hydrobromide + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride
Dimetapp ElixirBrompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride
Dimetapp ExtentabsBrompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride
Dimetapp Liqui-GelsBrompheniramine Maleate + Phenylpropanolamine Hydrochloride
Dimetapp Oral Infant DropsBrompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride
Dimetapp-CBrompheniramine Maleate + Codeine Phosphate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride
Dristan CapsulesAcetylsalicylic Acid + Caffeine + Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride
Emercidin DAcetaminophen + Caffeine + Diphenylpyraline Hydrochloride + Phenylpropanolamine Hydrochloride
EmertabsAcetaminophen + Caffeine + Phenylpropanolamine Hydrochloride
Entex LAGuaifenesin + Phenylpropanolamine Hydrochloride
Extra Strength Contac CChlorpheniramine Maleate + Phenylpropanolamine Hydrochloride
Oradrine 2Acetaminophen + Caffeine + Diphenylpyraline Hydrochloride + Phenylpropanolamine Hydrochloride
Oradrine TabletsAcetaminophen + Caffeine + Codeine Phosphate + Diphenylpyraline Hydrochloride + Phenylpropanolamine Hydrochloride
Ornade AF LiquidChlorpheniramine Maleate + Phenylpropanolamine Hydrochloride
Ornade AF SpansuleChlorpheniramine Maleate + Phenylpropanolamine Hydrochloride
Ornade DMChlorpheniramine Maleate + Dextromethorphan Hydrobromide + Phenylpropanolamine Hydrochloride
Ornade Expectorant Cough FormulaChlorpheniramine Maleate + Guaifenesin + Phenylpropanolamine Hydrochloride
Ornade LiquidChlorpheniramine Maleate + Phenylpropanolamine Hydrochloride
Ornade SpansuleChlorpheniramine Maleate + Phenylpropanolamine Hydrochloride
Partuss-LAGuaifenesin + Phenylpropanolamine Hydrochloride
Pharmacol DMDextromethorphan Hydrobromide + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate
Pharmetapp ElixirBrompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride
Pharminicol DM SyrupDextromethorphan Hydrobromide + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate
Sine Off NDAcetaminophen + Phenylpropanolamine Hydrochloride
Sine-Off AllergyAcetaminophen + Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride
Sinutab SAAcetaminophen + Phenylpropanolamine Hydrochloride + Phenyltoloxamine Citrate
Tantacol DMDextromethorphan Hydrobromide + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate
Tantapp ElixirBrompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride
Tavist-DClemastine (Clemastine Hydrogen Fumarate) + Phenylpropanolamine Hydrochloride
Tri-Anamine Cold SyrupChlorpheniramine Maleate + Phenylpropanolamine Hydrochloride
Tri-Anamine Expect AntihistGuaifenesin + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate
Triaminic Cold and Allergy SyrupChlorpheniramine Maleate + Phenylpropanolamine Hydrochloride
Triaminic DM DaytimeDextromethorphan Hydrobromide + Guaifenesin + Phenylpropanolamine Hydrochloride
Triaminic Expectorant DH SyrupGuaifenesin + Hydrocodone Bitartrate + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate
Triaminic Time ReleasePheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate
Triaminicin Colds & Flu CapletsAcetaminophen + Caffeine + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate
TrisulfaminicPheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate + Sulfadiazine + Sulfamerazine + Sulfamethazine
Tussaminic C Forte SyrupCodeine Phosphate + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate
Tussaminic C Pediatric SyrupCodeine Phosphate + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate
Tussaminic Dh Forte SyrupHydrocodone Bitartrate + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate
Tussaminic DH Pediatric SyrupHydrocodone Bitartrate + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate
Categories
CAS number14838-15-4
WeightAverage: 151.2056
Monoisotopic: 151.099714043
Chemical FormulaC9H13NO
InChI KeyDLNKOYKMWOXYQA-VXNVDRBHSA-N
InChI
InChI=1S/C9H13NO/c1-7(10)9(11)8-5-3-2-4-6-8/h2-7,9,11H,10H2,1H3/t7-,9-/m1/s1
IUPAC Name
(1S,2R)-2-amino-1-phenylpropan-1-ol
SMILES
C[C@@H](N)[C@@H](O)C1=CC=CC=C1
Mass SpecNot Available
Taxonomy
KingdomOrganic Compounds
SuperclassBenzenoids
ClassBenzene and Substituted Derivatives
SubclassPhenethylamines
Direct parentAmphetamines and Derivatives
Alternative parentsSecondary Alcohols; 1,2-Aminoalcohols; Polyamines; Monoalkylamines
Substituents1,2-aminoalcohol; secondary alcohol; polyamine; primary amine; amine; primary aliphatic amine; alcohol; organonitrogen compound
Classification descriptionThis compound belongs to the amphetamines and derivatives. These are organic compounds containing or derived from 1-phenylpropan-2-amine.
Pharmacology
IndicationFor the treatment of nasal congestion, control of urinary incontinence, priapism and obesity.
PharmacodynamicsPhenylpropanolamine (PPA), a sympathomimetic agent structurally similar to pseudoephedrine, is used to treat nasal congestion. Phenylpropanolamine is found in appetite suppressant formulations and with guaifenesinin in cough-cold formulations. In 2000, the FDA requested that all drug companies discontinue marketing products containing phenylpropanolamine, due to an increased risk of hemorrhagic stroke in women who used phenylpropanolamine.
Mechanism of actionPhenylpropanolamine acts directly on alpha- and, to a lesser degree, beta-adrenergic receptors in the mucosa of the respiratory tract. Stimulation of alpha-adrenergic receptors produces vasoconstriction, reduces tissue hyperemia, edema, and nasal congestion, and increases nasal airway patency. PPA indirectly stimulates beta-receptors, producing tachycardia and a positive inotropic effect.
AbsorptionReduced bioavailability (about 38%) from gastrointestinal tract because of first pass metabolism by monoamine oxidase in the stomach and liver.
Volume of distributionNot Available
Protein bindingNot Available
Metabolism

Hepatic

Route of eliminationNot Available
Half life2.1 to 3.4 hours.
ClearanceNot Available
ToxicityMay induce ventricular extrasystoles and short paroxysms of ventricular tachycardia, a sensation of fullness in the head and tingling of the extremities; LD50=1490mg/kg (orally in rat)
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
Property Value Probability
Human Intestinal Absorption + 0.9871
Blood Brain Barrier + 0.5843
Caco-2 permeable + 0.7568
P-glycoprotein substrate Non-substrate 0.7276
P-glycoprotein inhibitor I Non-inhibitor 0.9849
P-glycoprotein inhibitor II Non-inhibitor 0.9917
Renal organic cation transporter Non-inhibitor 0.9113
CYP450 2C9 substrate Non-substrate 0.8077
CYP450 2D6 substrate Non-substrate 0.8418
CYP450 3A4 substrate Non-substrate 0.8063
CYP450 1A2 substrate Non-inhibitor 0.9046
CYP450 2C9 substrate Non-inhibitor 0.9071
CYP450 2D6 substrate Non-inhibitor 0.9231
CYP450 2C19 substrate Non-inhibitor 0.9026
CYP450 3A4 substrate Non-inhibitor 0.9261
CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.9096
Ames test Non AMES toxic 0.9132
Carcinogenicity Non-carcinogens 0.6929
Biodegradation Not ready biodegradable 0.6917
Rat acute toxicity 2.0244 LD50, mol/kg Not applicable
hERG inhibition (predictor I) Weak inhibitor 0.9446
hERG inhibition (predictor II) Non-inhibitor 0.937
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage formsNot Available
Prices
Unit descriptionCostUnit
Naldecon Senior EX 200 mg/5ml Syrup 118ml Bottle15.99USDbottle
Entex ER 10-300 mg 12 Hour Capsule1.14USDcapsule
Codimal la capsule0.7USDcapsule
Despec-dm tablet0.61USDtablet
Despec-tab tablet0.47USDtablet
Triaminic allergy thin strip0.35USDstrip
Triaminic cold-stuff nose strip0.35USDstrip
Conex tablet0.33USDtablet
Triaminic cgh-runny nose strip0.3USDstrip
Triaminic cough strips0.3USDstrip
Triaminic cough-cold chew0.27USDeach
Triaminic softchew tablet0.27USDtablet
Triaminic softchews tablet0.25USDtablet
Childrens triaminic decon spray0.24USDml
Triaminicin tablet0.23USDtablet
Dexatrim natural caplet0.19USDcaplet
Codimal DH 5-8.33-1.66 mg/5ml Syrup0.18USDml
Despec-exp syrup0.18USDml
Codimal dm syrup0.16USDml
Naldecon-dx senior0.06USDml
Apap allergy sinus caplet0.05USDcaplet
Triaminic chest-nasal cong liq0.04USDml
Triaminic cold & cough liquid0.04USDml
Triaminic cold-allergy pe liq0.04USDml
Triaminic cough-nasal cong liquid0.04USDml
Triaminic cough-sore throat liquid0.04USDml
Triaminic flu cough-fever suspension0.04USDml
Triaminic flu-cough-fever liquid0.04USDml
Triaminic-d syrup0.04USDml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
Statesolid
Experimental Properties
PropertyValueSource
melting point190-194 °CNot Available
water solubilityFreely solubleNot Available
logP0.67SANGSTER (1994)
pKa9.44 (at 20 °C)PERRIN,DD (1965)
Predicted Properties
PropertyValueSource
water solubility2.06e+01 g/lALOGPS
logP0.57ALOGPS
logP0.89ChemAxon
logS-0.87ALOGPS
pKa (strongest acidic)13.9ChemAxon
pKa (strongest basic)9.37ChemAxon
physiological charge1ChemAxon
hydrogen acceptor count2ChemAxon
hydrogen donor count2ChemAxon
polar surface area46.25ChemAxon
rotatable bond count2ChemAxon
refractivity44.91ChemAxon
polarizability16.98ChemAxon
number of rings1ChemAxon
bioavailability1ChemAxon
rule of fiveYesChemAxon
Ghose filterNoChemAxon
Veber's ruleNoChemAxon
MDDR-like ruleNoChemAxon
Spectra
SpectraMS/MS1D NMR2D NMR
References
Synthesis ReferenceNot Available
General ReferenceNot Available
External Links
ResourceLink
KEGG CompoundC07911
PubChem Compound26934
PubChem Substance46508087
ChemSpider25082
Therapeutic Targets DatabaseDNC001144
PharmGKBPA164748965
Drug Product Database2247031
Drugs.comhttp://www.drugs.com/mtm/phenylpropanolamine.html
WikipediaPhenylpropanolamine
ATC CodesR01BA01
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSshow(52.4 KB)
Interactions
Drug Interactions
Drug
AcetophenazineDecreased anorexic effect, may increase psychotic symptoms
AlimemazineDecreased anorexic effect, may increase psychotic symptoms
AlseroxylonIncreased arterial pressure
AmitriptylineThe tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect of phenylpropanolamine.
AmoxapineThe tricyclic antidepressant, amoxapine, increases the sympathomimetic effect of phenylpropanolamine.
BromocriptineThe sympathomimetic, phenylpropanolamine, increases the toxicity of bromocriptine.
ChlorpromazineDecreased anorexic effect, may increase psychotic symptoms
ClomipramineThe tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of phenylpropanolamine.
DeserpidineIncreased arterial pressure
DesipramineThe tricyclic antidepressant, desipramine, increases the sympathomimetic effect of phenylpropanolamine.
DoxepinThe tricyclic antidepressant, doxepin, increases the sympathomimetic effect of phenylpropanolamine.
EthopropazineDecreased anorexic effect, may increase psychotic symptoms
FluoxetineRisk of serotoninergic syndrome
FluphenazineDecreased anorexic effect, may increase psychotic symptoms
FluvoxamineRisk of serotoninergic syndrome
GuanethidinePhenylpropanolamine may decrease the effect of guanethidine.
ImipramineThe tricyclic antidepressant, imipramine, increases the sympathomimetic effect of phenylpropanolamine.
IobenguaneSympathomimetic that increase chances of producing a false negative imaging result
IsocarboxazidIncreased arterial pressure
LinezolidPossible increase of arterial pressure
MesoridazineDecreased anorexic effect, may increase psychotic symptoms
MethdilazineDecreased anorexic effect, may increase psychotic symptoms
MethotrimeprazineDecreased anorexic effect, may increase psychotic symptoms
MethyldopaIncreased arterial pressure
MidodrineIncreased arterial pressure
MoclobemideMoclobemide increases the sympathomimetic effect of phenylpropanolamine.
NortriptylineThe tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of phenylpropanolamine.
PargylineIncreased arterial pressure
ParoxetineRisk of serotoninergic syndrome
PerphenazineDecreased anorexic effect, may increase psychotic symptoms
PhenelzineIncreased arterial pressure
ProchlorperazineDecreased anorexic effect, may increase psychotic symptoms.
PromazineDecreased anorexic effect, may increase psychotic symptoms
PromethazineDecreased anorexic effect, may increase psychotic symptoms.
PropericiazineDecreased anorexic effect, may increase psychotic symptoms.
PropiomazineDecreased anorexic effect, may increase psychotic symptoms
ProtriptylineThe tricyclic antidepressant, protriptyline, increases the sympathomimetic effect of phenylpropanolamine.
RasagilineIncreased arterial pressure
ReserpineIncreased arterial pressure
ThiethylperazineDecreased anorexic effect, may increase psychotic symptoms
ThioridazineDecreased anorexic effect, may increase psychotic symptoms
TranylcypromineIncreased arterial pressure
TrifluoperazineDecreased anorexic effect, may increase psychotic symptoms
TriflupromazineDecreased anorexic effect, may increase psychotic symptoms
TrimipramineThe tricyclic antidepressant, trimipramine, increases the sympathomimetic effect of phenylpropanolamine.
VenlafaxineRisk of serotoninergic syndrome
Food Interactions
  • Limit caffeine intake.
  • Take without regard to meals.

Targets

1. Alpha-1A adrenergic receptor

Kind: protein

Organism: Human

Pharmacological action: yes

Actions: agonist

Components

Name UniProt ID Details
Alpha-1A adrenergic receptor P35348 Details

References:

  1. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  2. Wellman PJ, McMahon LR, Green T, Tole A: Effects of the alpha 1a-adrenoceptor antagonist RS-17053 on phenylpropanolamine-induced anorexia in rats. Pharmacol Biochem Behav. 1997 May-Jun;57(1-2):281-4. Pubmed
  3. Buckner SA, Milicic I, Daza AV, Meyer MD, Altenbach RJ, Williams M, Sullivan JP, Brioni JD: ABT-866, a novel alpha(1A)-adrenoceptor agonist with antagonist properties at the alpha(1B)- and alpha(1D)-adrenoceptor subtypes. Eur J Pharmacol. 2002 Aug 2;449(1-2):159-65. Pubmed
  4. Altenbach RJ, Khilevich A, Kolasa T, Rohde JJ, Bhatia PA, Patel MV, Searle XB, Yang F, Bunnelle WH, Tietje K, Bayburt EK, Carroll WA, Meyer MD, Henry R, Buckner SA, Kuk J, Daza AV, Milicic IV, Cain JC, Kang CH, Ireland LM, Carr TL, Miller TR, Hancock AA, Nakane M, Esbenshade TA, Brune ME, O’Neill AB, Gauvin DM, Katwala SP, Holladay MW, Brioni JD, Sullivan JP: Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonami de, an imidazole-containing alpha(1A)-adrenoceptor agonist. J Med Chem. 2004 Jun 3;47(12):3220-35. Pubmed
  5. Moya-Huff FA, Maher TJ: Adrenergic receptor subtype activation by ()-, (-)- and (/-)-norephedrine in the pithed rat. J Pharm Pharmacol. 1987 Feb;39(2):108-12. Pubmed

2. Alpha-2A adrenergic receptor

Kind: protein

Organism: Human

Pharmacological action: yes

Actions: agonist

Components

Name UniProt ID Details
Alpha-2A adrenergic receptor P08913 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Flavahan NA: Phenylpropanolamine constricts mouse and human blood vessels by preferentially activating alpha2-adrenoceptors. J Pharmacol Exp Ther. 2005 Apr;313(1):432-9. Epub 2004 Dec 17. Pubmed

3. D(1A) dopamine receptor

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: partial agonist

Components

Name UniProt ID Details
D(1A) dopamine receptor P21728 Details

References:

  1. Cheng JT, Kuo DY: Both alpha1-adrenergic and D(1)-dopaminergic neurotransmissions are involved in phenylpropanolamine-mediated feeding suppression in mice. Neurosci Lett. 2003 Aug 21;347(2):136-8. Pubmed

4. Beta-1 adrenergic receptor

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: agonist

Components

Name UniProt ID Details
Beta-1 adrenergic receptor P08588 Details

References:

  1. Thomas SH, Clark KL, Allen R, Smith SE: A comparison of the cardiovascular effects of phenylpropanolamine and phenylephrine containing proprietary cold remedies. Br J Clin Pharmacol. 1991 Dec;32(6):705-11. Pubmed
  2. Moya-Huff FA, Maher TJ: Adrenergic receptor subtype activation by ()-, (-)- and (/-)-norephedrine in the pithed rat. J Pharm Pharmacol. 1987 Feb;39(2):108-12. Pubmed

5. Beta-2 adrenergic receptor

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: agonist

Components

Name UniProt ID Details
Beta-2 adrenergic receptor P07550 Details

References:

  1. Moya-Huff FA, Maher TJ: Adrenergic receptor subtype activation by ()-, (-)- and (/-)-norephedrine in the pithed rat. J Pharm Pharmacol. 1987 Feb;39(2):108-12. Pubmed

Enzymes

1. Amine oxidase [flavin-containing] A

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Amine oxidase [flavin-containing] A P21397 Details

References:

  1. Yu PH: Inhibition of monoamine oxidase activity by phenylpropanolamine, an anorectic agent. Res Commun Chem Pathol Pharmacol. 1986 Feb;51(2):163-71. Pubmed

2. Cytochrome P450 1A2

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Cytochrome P450 1A2 P05177 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

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Drug created on June 13, 2005 07:24 / Updated on March 13, 2014 11:46