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Identification
NameMethocarbamol
Accession NumberDB00423  (APRD01102)
TypeSmall Molecule
GroupsApproved, Vet Approved
Description

A centrally acting muscle relaxant whose mode of action has not been established. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1206)

Structure
Thumb
Synonyms
(RS)-2-hydroxy-3-(2-methoxyphenoxy)propyl carbamate
Delaxin
Methocarbamol
Méthocarbamol
Methocarbamolum
Metocarbamol
Metocarbamolo
Robaxin
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Methocarbamol Inj 100mg/mlliquid100 mgintramuscular; intravenousUnivet Pharmaceuticals Ltd.1988-12-31Not applicableCanada
Methocarbamol Omegaliquid100 mgintramuscular; intravenousOmega Laboratories Ltd2003-07-28Not applicableCanada
PMS-methocarbamol Inj 100mg/mlliquid100 mgintramuscular; intravenousPharmascience Inc1990-12-31Not applicableCanada
Robaximol Inj 100mg/mlliquid100 mgintramuscular; intravenousMontreal Veterinary Products Inc.1989-12-31Not applicableCanada
Robaxininjection100 mg/mLintramuscular; intravenousWest Ward Pharmaceutical Corp.1959-06-16Not applicableUs
Robaxintablet, film coated750 mg/1oralPd Rx Pharmaceuticals, Inc.2003-01-20Not applicableUs
Robaxintablet, film coated750 mg/1oralActient Pharmaceuticals, LLC2011-08-18Not applicableUs
Robaxintablet, film coated500 mg/1oralActient Pharmaceuticals, LLC2012-05-15Not applicableUs
Robaxintablet500 mg/1oralREMEDYREPACK INC.2012-08-16Not applicableUs
Robaxintablet, film coated750 mg/1oralSTAT Rx USA LLC2003-01-20Not applicableUs
Robaxin Inj 100mg/mlliquid100 mgintramuscular; intravenousAyerst Laboratories1992-12-311997-08-15Canada
Robaxin Injectable Liq 100mg/mlliquid100 mgintramuscular; intravenousWyeth Ayerst Canada Inc.1996-10-252000-03-07Canada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Methocarbamoltablet500 mg/1oralbryant ranch prepack2010-03-01Not applicableUs
Methocarbamoltablet, film coated750 mg/1oralVirtus Pharmaceuticals2015-07-13Not applicableUs
Methocarbamoltablet500 mg/1oralREMEDYREPACK INC.2014-10-13Not applicableUs
Methocarbamoltablet500 mg/1oralKeltman Pharmaceuticals Inc.2009-05-08Not applicableUs
Methocarbamoltablet750 mg/1oralContract Pharmacy Services Pa2000-01-01Not applicableUs
Methocarbamoltablet750 mg/1oralClinical Solutions Wholesale, Llc2013-03-20Not applicableUs
Methocarbamoltablet500 mg/1oralREMEDYREPACK INC.2012-03-12Not applicableUs
Methocarbamoltablet, film coated500 mg/1oralVirtus Pharmaceuticals2013-12-15Not applicableUs
Methocarbamoltablet500 mg/1oralPd Rx Pharmaceuticals, Inc.2000-01-01Not applicableUs
Methocarbamoltablet500 mg/1oralA S Medication Solutions Llc2000-01-01Not applicableUs
Methocarbamoltablet750 mg/1oralRebel Distributors Corp2010-03-01Not applicableUs
Methocarbamoltablet750 mg/1oralNorthwind Pharmaceuticals, LLC2014-09-23Not applicableUs
Methocarbamoltablet750 mg/1oralGolden State Medical Supply, Inc.2015-01-13Not applicableUs
Methocarbamoltablet750 mg/1oralREMEDYREPACK INC.2012-03-27Not applicableUs
Methocarbamoltablet500 mg/1oralCardinal Health2007-07-03Not applicableUs
Methocarbamoltablet750 mg/1oralA S Medication Solutions Llc2000-01-01Not applicableUs
Methocarbamoltablet750 mg/1oralBlenheim Pharmacal, Inc.2014-01-22Not applicableUs
Methocarbamoltablet750 mg/1oralWatson Laboratories, Inc.1987-11-01Not applicableUs
Methocarbamoltablet500 mg/1oralWest Ward Pharmaceuticals Corp2000-01-01Not applicableUs
Methocarbamoltablet500 mg/1oralLake Erie Medical DBA Quality Care Products LLC2013-03-20Not applicableUs
Methocarbamoltablet500 mg/1oralREMEDYREPACK INC.2013-01-19Not applicableUs
Methocarbamoltablet750 mg/1oralBlenheim Pharmacal, Inc.2014-01-13Not applicableUs
Methocarbamoltablet500 mg/1oralDispensing Solutions, Inc.2000-01-01Not applicableUs
Methocarbamoltablet500 mg/1oralClinical Solutions Wholesale, Llc2013-03-20Not applicableUs
Methocarbamoltablet500 mg/1oralREMEDYREPACK INC.2013-09-27Not applicableUs
Methocarbamoltablet500 mg/1oralPd Rx Pharmaceuticals, Inc.2000-01-01Not applicableUs
Methocarbamoltablet750 mg/1oralA S Medication Solutions Llc2000-01-01Not applicableUs
Methocarbamoltablet750 mg/1oralUnit Dose Services2000-01-01Not applicableUs
Methocarbamoltablet500 mg/1oralGolden State Medical Supply, Inc.2015-01-13Not applicableUs
Methocarbamoltablet750 mg/1oralCardinal Health2007-07-09Not applicableUs
Methocarbamoltablet750 mg/1oralBlenheim Pharmacal, Inc.2000-01-01Not applicableUs
Methocarbamoltablet500 mg/1oralWatson Laboratories, Inc.1987-11-01Not applicableUs
Methocarbamoltablet750 mg/1oralLake Erie Medical DBA Quality Care Products LLC2003-01-29Not applicableUs
Methocarbamoltablet500 mg/1oralREMEDYREPACK INC.2015-06-02Not applicableUs
Methocarbamoltablet750 mg/1oralDispensing Solutions, Inc.2003-01-29Not applicableUs
Methocarbamoltablet750 mg/1oralProficient Rx LP2013-01-15Not applicableUs
Methocarbamoltablet, film coated500 mg/1oralVirtus Pharmaceuticals2015-07-13Not applicableUs
Methocarbamoltablet750 mg/1oralKeltman Pharmaceuticals Inc.2007-07-25Not applicableUs
Methocarbamoltablet500 mg/1oralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
Methocarbamoltablet500 mg/1oralUnit Dose Services2000-01-01Not applicableUs
Methocarbamoltablet, film coated750 mg/1oralGolden State Medical Supply, Inc.2014-02-20Not applicableUs
Methocarbamoltablet750 mg/1oralCardinal Health2003-01-29Not applicableUs
Methocarbamoltablet750 mg/1oralMajor Pharmaceuticals1976-08-18Not applicableUs
Methocarbamoltablet500 mg/1oralLiberty Pharmaceuticals, Inc.2003-01-29Not applicableUs
Methocarbamoltablet500 mg/1oralLake Erie Medical DBA Quality Care Products LLC2003-01-29Not applicableUs
Methocarbamoltablet750 mg/1oralREMEDYREPACK INC.2013-04-022016-03-12Us
Methocarbamoltablet750 mg/1oralHetero Drugs Limited Unit III2009-11-06Not applicableUs
Methocarbamoltablet500 mg/1oralProficient Rx LP2013-03-20Not applicableUs
Methocarbamoltablet500 mg/1oralAvera Mc Kennan Hospital2015-09-30Not applicableUs
Methocarbamoltablet750 mg/1oralAmerican Health Packaging2013-06-26Not applicableUs
Methocarbamoltablet750 mg/1oralCardinal Health2013-06-26Not applicableUs
Methocarbamoltablet500 mg/1oralREMEDYREPACK INC.2011-07-122016-03-17Us
Methocarbamoltablet750 mg/1oralPd Rx Pharmaceuticals, Inc.2000-01-01Not applicableUs
Methocarbamoltablet500 mg/1oralMajor Pharmaceuticals1976-08-11Not applicableUs
Methocarbamoltablet500 mg/1oralKAISER FOUNDATION HOSPITALS2008-08-02Not applicableUs
Methocarbamoltablet750 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2000-01-01Not applicableUs
Methocarbamoltablet750 mg/1oralRebel Distributors Corp.1976-08-18Not applicableUs
Methocarbamoltablet500 mg/1oralHetero Drugs Limited Unit III2009-11-06Not applicableUs
Methocarbamoltablet750 mg/1oralProficient Rx LP2013-03-20Not applicableUs
Methocarbamoltablet750 mg/1oralPreferred Pharmaceuticals Inc.2015-08-20Not applicableUs
Methocarbamoltablet500 mg/1oralAmerican Health Packaging2013-06-26Not applicableUs
Methocarbamoltablet, film coated500 mg/1oralCarilion Materials Management2013-12-15Not applicableUs
Methocarbamoltablet750 mg/1oralMedsource Pharmaceuticals2013-01-15Not applicableUs
Methocarbamoltablet500 mg/1oralPd Rx Pharmaceuticals, Inc.2003-01-29Not applicableUs
Methocarbamoltablet750 mg/1oralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
Methocarbamoltablet750 mg/1oralAv Pak2014-10-20Not applicableUs
Methocarbamoltablet, film coated500 mg/1oralGolden State Medical Supply, Inc.2014-02-20Not applicableUs
Methocarbamoltablet500 mg/1oralCardinal Health2003-01-29Not applicableUs
Methocarbamoltablet750 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2003-01-29Not applicableUs
Methocarbamoltablet500 mg/1oralKAISER FOUNDATION HOSPITALS2015-06-04Not applicableUs
Methocarbamoltablet500 mg/1oralAidarex Pharmaceuticals LLC2000-01-01Not applicableUs
Methocarbamoltablet500 mg/1oralRebel Distributors Corp.2000-01-01Not applicableUs
Methocarbamoltablet750 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2003-01-29Not applicableUs
Methocarbamoltablet, film coated750 mg/1oralDIRECT RX2015-01-01Not applicableUs
Methocarbamoltablet500 mg/1oralPreferred Pharmaceuticals, Inc.2014-11-18Not applicableUs
Methocarbamoltablet500 mg/1oralAphena Pharma Solutions Tennessee, Inc.2000-01-01Not applicableUs
Methocarbamoltablet750 mg/1oralBlenheim Pharmacal, Inc.2016-01-07Not applicableUs
Methocarbamoltablet750 mg/1oralSolco Healthcare US LLC2013-01-15Not applicableUs
Methocarbamoltablet750 mg/1oralPd Rx Pharmaceuticals, Inc.2003-01-29Not applicableUs
Methocarbamoltablet500 mg/1oralH.J. Harkins Company, Inc.1987-11-01Not applicableUs
Methocarbamoltablet500 mg/1oralAv Pak2014-10-20Not applicableUs
Methocarbamoltablet750 mg/1oralClinical Solutions Wholesale2003-01-29Not applicableUs
Methocarbamoltablet750 mg/1oralPhysicians Total Care, Inc.2003-07-14Not applicableUs
Methocarbamoltablet750 mg/1oralSTAT Rx USA LLC2000-01-01Not applicableUs
Methocarbamoltablet500 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2003-01-29Not applicableUs
Methocarbamoltablet750 mg/1oralDIRECT RX2015-01-01Not applicableUs
Methocarbamoltablet750 mg/1oralPreferred Pharmaceuticals, Inc.2014-11-25Not applicableUs
Methocarbamoltablet750 mg/1oralAphena Pharma Solutions Tennessee, Inc.2000-01-01Not applicableUs
Methocarbamoltablet750 mg/1oralAmerican Health Packaging2013-05-062015-12-29Us
Methocarbamoltablet500 mg/1oralSolco Healthcare US LLC2013-01-15Not applicableUs
Methocarbamoltablet500 mg/1oralSTAT Rx USA LLC1987-11-01Not applicableUs
Methocarbamoltablet750 mg/1oralH.J. Harkins Company, Inc.1987-11-01Not applicableUs
Methocarbamoltablet750 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-11-16Not applicableUs
Methocarbamoltablet500 mg/1oralClinical Solutions Wholesale2000-01-01Not applicableUs
Methocarbamoltablet500 mg/1oralPhysicians Total Care, Inc.2009-07-21Not applicableUs
Methocarbamoltablet500 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2003-01-09Not applicableUs
Methocarbamoltablet750 mg/1oralKAISER FOUNDATION HOSPITALS2011-06-07Not applicableUs
Methocarbamoltablet750 mg/1oralAidarex Pharmaceuticals LLC2000-01-01Not applicableUs
Methocarbamoltablet750 mg/1oralbryant ranch prepack2003-01-29Not applicableUs
Methocarbamoltablet500 mg/1oralDIRECT RX2015-01-01Not applicableUs
Methocarbamoltablet750 mg/1oralPreferred Pharmaceuticals, Inc.2010-08-06Not applicableUs
Methocarbamolinjection, solution100 mg/mLintramuscular; intravenousMylan Institutional LLC2014-12-05Not applicableUs
Methocarbamoltablet500 mg/1oralAmerican Health Packaging2013-05-062015-12-29Us
Methocarbamoltablet500 mg/1oralAphena Pharma Solutions Tennessee, Llc2003-01-29Not applicableUs
Methocarbamoltablet750 mg/1oralSTAT Rx USA LLC1987-11-01Not applicableUs
Methocarbamoltablet750 mg/1oralREMEDYREPACK INC.2015-06-22Not applicableUs
Methocarbamoltablet500 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-11-16Not applicableUs
Methocarbamoltablet500 mg/1oralPd Rx Pharmaceuticals, Inc.2010-03-01Not applicableUs
Methocarbamoltablet750 mg/1oralA S Medication Solutions Llc2000-01-01Not applicableUs
Methocarbamoltablet750 mg/1oralQualitest Pharmaceuticals2003-01-29Not applicableUs
Methocarbamoltablet500 mg/1oralKAISER FOUNDATION HOSPITALS2011-06-06Not applicableUs
Methocarbamoltablet750 mg/1oralCamber Pharmaceuticals, Inc.2013-03-20Not applicableUs
Methocarbamoltablet500 mg/1oralSTAT Rx USA LLC2000-01-01Not applicableUs
Methocarbamoltablet750 mg/1oralbryant ranch prepack2003-01-29Not applicableUs
Methocarbamoltablet750 mg/1oralREMEDYREPACK INC.2015-12-24Not applicableUs
Methocarbamoltablet500 mg/1oralPreferred Pharmaceuticals, Inc.2010-08-06Not applicableUs
Methocarbamoltablet750 mg/1oralContract Pharmacy Services Pa2010-03-01Not applicableUs
Methocarbamoltablet, film coated750 mg/1oralVirtus Pharmaceuticals2013-12-15Not applicableUs
Methocarbamoltablet750 mg/1oralAphena Pharma Solutions Tennessee, Llc2003-01-29Not applicableUs
Methocarbamoltablet500 mg/1oralRebel Distributors Corp2010-03-01Not applicableUs
Methocarbamoltablet500 mg/1oralREMEDYREPACK INC.2014-01-08Not applicableUs
Methocarbamoltablet500 mg/1oralREMEDYREPACK INC.2012-07-10Not applicableUs
Methocarbamoltablet750 mg/1oralPd Rx Pharmaceuticals, Inc.1987-11-01Not applicableUs
Methocarbamoltablet500 mg/1oralA S Medication Solutions Llc2000-01-01Not applicableUs
Methocarbamoltablet500 mg/1oralQualitest Pharmaceuticals2003-01-29Not applicableUs
Methocarbamoltablet750 mg/1oralWest Ward Pharmaceuticals Corp2000-01-01Not applicableUs
Methocarbamoltablet500 mg/1oralCamber Pharmaceuticals, Inc.2013-03-20Not applicableUs
Methocarbamoltablet500 mg/1oralBlenheim Pharmacal, Inc.2014-01-22Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Robaxintablet500 mgoralPfizer Consumer Healthcare A Division Of Pfizer Canada Inc1958-12-31Not applicableCanada
Robaxin 750tablet750 mgoralPfizer Consumer Healthcare A Division Of Pfizer Canada Inc1993-12-31Not applicableCanada
Unapproved/Other Products Not Available
International Brands
NameCompany
BolaxinYing Yuan
CarbaflexPaill
DelaxinNot Available
DoloVisanDr.Kade Pharmaceutische Fabrik
FubaxinGrape King
LumirelaxJuvise
MetocarbamolAZ Pharma
MioflexLabinco
MiorelCheminter
MusxanPharmasant
OrtotonRecordati
RebamolWinston
Robaxin-750Pfizer
RobinaxKhandelwal
SinaxarArmofar
TaspanHonten
Brand mixtures
NameLabellerIngredients
A.S.A. With Methocarbamol Night-time Extra StrengthPharmetics (2011) Inc
Acetaminophen 325mg + Methocarbamol 400mg CapletsInternational Pharmaceutical Generics Ltd
Acetaminophen 500mg + Methocarbamol 400mg Extra Strength CapletsInternational Pharmaceutical Generics Ltd
Advil Back PainPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Analgesic and Muscle RelaxantPharmascience Inc
Analgesic and Muscle Relaxant CapletsTeva Canada Limited
Aspirin BackacheBayer Inc Consumer Care
Aspirin Night-timeBayer Inc Consumer Care
Axacet-C1/8Technilab Pharma Inc.
Axisal-C1/8Technilab Pharma Inc.
AxumTeva Canada Limited
Dodd's Back-ease Muscle Spasm and Back Pain ReliefStella Pharmaceutical Canada Inc.
Dodd's Extra Strength Back-easeStella Pharmaceutical Canada Inc.
Douleurs Musculaires Et Les Courbatures Extra Fort/muscle and Back Pain Relief Extra StrengthProdemdis Enr.
Extra Strength Aspirin BackacheBayer Inc Consumer Care
Extra Strength Back PainPharmetics (2011) Inc
Extra Strength Body Pain NightPharmetics (2011) Inc
Extra Strength Muscle & Back Pain Asa 500 Mg Methocarbamol 400 Mg & Acetylsalicylic Acid 500 mgVita Health Products Inc
Extra Strength Muscle & Back Pain ReliefVita Health Products Inc
Extra Strength Muscle & Back Pain Relief With AsaVita Health Products Inc
Extra Strength Tylenol Back PainMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol Body Pain NightMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Ibuprofen+methocarbamol CapletsInternational Pharmaceutical Generics Ltd
MethoxacetTeva Canada Limited
Methoxacet Extra StrengthTeva Canada Limited
Methoxacet-C 1/8Teva Canada Limited
MethoxisalRougier Pharma Division Of Ratiopharm Inc
Methoxisal Extra StrengthTeva Canada Limited
Methoxisal-C 1/2Teva Canada Limited
Methoxisal-C 1/4Teva Canada Limited
Methoxisal-C 1/8Teva Canada Limited
Midol Night-timeBayer Inc Consumer Care
Motrin Platinum Muscle and BodyMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Muscle & Back Pain Asa 325 Mg Methocarbamol 400 Mg & Acetylsalicylic Acid 325 mgVita Health Products Inc
Muscle & Back Pain ReliefPendopharm Division Of De Pharmascience Inc
Muscle & Back Pain Relief - 8Vita Health Products Inc
Muscle & Back Pain Relief CapletsJamp Pharma Corporation
Muscle & Back Pain Relief Extra StrengthPendopharm Division Of De Pharmascience Inc
Muscle & Back Pain Relief With IbuprofenTeva Canada Limited
Muscle & Back Pain Relief-8Pharmascience Inc
Muscle and Back Pain Platinum ReliefVita Health Products Inc
Muscle and Back Pain ReliefPendopharm Division Of De Pharmascience Inc
Muscle and Back Pain Relief - 8 TabletsPharmetics (2011) Inc
Muscle and Back Pain Relief CapletsJamp Pharma Corporation
Muscle and Back Pain Relief Extra StrengthPendopharm Division Of De Pharmascience Inc
Muscle and Back Pain Relief Extra Strength TabletsPharmetics (2011) Inc
Muscle and Back Pain Relief Regular Strength TabletsPharmetics (2011) Inc
Muscle and Back Pain Relief With AsaTechnilab Pharma Inc.
Muscle and Back Pain Relief With Asa Extra StrengthTechnilab Pharma Inc.
Muscle and Back Pain Relief-8Teva Canada Limited
Muscle Relaxant and AnalgesicTechnilab Pharma Inc.
Muscle Relaxant and Analgesic CapletsInternational Pharmaceutical Generics Ltd
Muscle Relaxant and Back Pain Relief Extra Strength TabletsPharmetics (2011) Inc
Muscle Relaxant and Back Pain Relief Regular Strength TabletsPharmetics (2011) Inc
Nighttime Body PainVita Health Products Inc
Platinum Muscle and Back Pain ReliefVita Health Products Inc
Regular Strength Analgesic & Muscle Relaxant CapletsTeva Canada Limited
Regular Strength Tylenol Back PainMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Regular Strength Tylenol Body Pain NightMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Relaxophen CapletsTanta Pharmaceuticals Inc
Robax PlatinumPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
RobaxacetPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Robaxacet Extra StrengthPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Robaxacet TabletsWyeth Consumer Healthcare Inc.
Robaxacet-8Pfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Robaxisal C 1/2Pfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Robaxisal C 1/4Pfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Robaxisal C-1/8 TabletsWyeth Consumer Healthcare Inc.
Robaxisal CapletsWyeth Consumer Healthcare Inc.
Robaxisal Extra StrengthPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Robaxisal TabletsWyeth Consumer Healthcare Inc.
Soulagement Des Douleurs Musculaires & Courbatures Extra FortPharmalab Inc.
Spasmhalt-8Pendopharm Division Of De Pharmascience Inc
Spasmhalt-asa-8Pendopharm Division Of De Pharmascience Inc
Summit UltraPendopharm Division Of De Pharmascience Inc
Super Extra Strength Aspirin BackacheBayer Inc Consumer Care
SaltsNot Available
Categories
UNII125OD7737X
CAS number532-03-6
WeightAverage: 241.2405
Monoisotopic: 241.095022595
Chemical FormulaC11H15NO5
InChI KeyInChIKey=GNXFOGHNGIVQEH-UHFFFAOYSA-N
InChI
InChI=1S/C11H15NO5/c1-15-9-4-2-3-5-10(9)16-6-8(13)7-17-11(12)14/h2-5,8,13H,6-7H2,1H3,(H2,12,14)
IUPAC Name
2-hydroxy-3-(2-methoxyphenoxy)propyl carbamate
SMILES
COC1=CC=CC=C1OCC(O)COC(N)=O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as anisoles. These are organic compounds containing a methoxybenzene or a derivative thereof.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassPhenol ethers
Direct ParentAnisoles
Alternative Parents
Substituents
  • Anisole
  • Alkyl aryl ether
  • Secondary alcohol
  • Ether
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Alcohol
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationFor use as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions.
PharmacodynamicsMethocarbamol is a central muscle relaxant for skeletal muscles, used to treat spasms. It is structurally related to guaifenesin. Methocarbamol's exact mechanism of causing skeletal muscle relaxation is unknown. It is thought to work centrally, perhaps by general depressant effects. It has no direct relaxant effects on striated muscle, nerve fibers, or the motor endplate. It will not directly relax contracted skeletal muscles. The drug has a secondary sedative effect.
Mechanism of actionThe mechanism of action of methocarbamol in humans has not been established, but may be due to central nervous system depression. It has no direct action on the contractile mechanism of striated muscle, the motor end plate or the nerve fiber.
Related Articles
AbsorptionRapid. Onset of action is about 30 minutes after oral administration.
Volume of distributionNot Available
Protein bindingNot Available
Metabolism

Hepatic.

Route of eliminationSmall amounts of unchanged methocarbamol also are excreted in the urine.
Half life1.14-1.24 hours
Clearance
  • 0.2 – 0.8 L/h/kg [healthy]
ToxicitySymptoms of overdose include blurred vision, coma, drowsiness, low blood pressure, nausea, and seizures.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9638
Blood Brain Barrier+0.5747
Caco-2 permeable-0.6689
P-glycoprotein substrateNon-substrate0.6452
P-glycoprotein inhibitor INon-inhibitor0.9411
P-glycoprotein inhibitor IINon-inhibitor0.8887
Renal organic cation transporterNon-inhibitor0.9105
CYP450 2C9 substrateNon-substrate0.8431
CYP450 2D6 substrateNon-substrate0.7658
CYP450 3A4 substrateNon-substrate0.606
CYP450 1A2 substrateInhibitor0.9107
CYP450 2C9 inhibitorNon-inhibitor0.9302
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorNon-inhibitor0.9066
CYP450 3A4 inhibitorNon-inhibitor0.9338
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9542
Ames testNon AMES toxic0.5776
CarcinogenicityNon-carcinogens0.9406
BiodegradationNot ready biodegradable0.8358
Rat acute toxicity2.2930 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.984
hERG inhibition (predictor II)Non-inhibitor0.9411
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Marsam pharmaceuticals llc
  • Watson laboratories inc
  • Baxter healthcare corp anesthesia critical care
  • Ferndale laboratories inc
  • Forest laboratories inc
  • Able laboratories inc
  • American therapeutics inc
  • Ascot hosp pharmaceuticals inc div travenol laboratories inc
  • Clonmel healthcare ltd
  • Heather drug co inc
  • Hetero drugs ltd
  • Impax laboratories inc
  • Inwood laboratories inc sub forest laboratories inc
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Kv pharmaceutical co
  • Lannett co inc
  • Mutual pharmaceutical co inc
  • Mylan pharmaceuticals inc
  • Nylos trading co inc
  • Pharmeral inc
  • Pioneer pharmaceuticals inc
  • Purepac pharmaceutical co
  • Roxane laboratories inc
  • Sandoz inc
  • Solco healthcare us llc
  • Solvay pharmaceuticals
  • Superpharm corp
  • Tablicaps inc
  • Upsher smith laboratories inc
  • Vintage pharmaceuticals inc
  • West ward pharmaceutical corp
  • Schwarz pharma inc
Packagers
Dosage forms
FormRouteStrength
Injection, solutionintramuscular; intravenous100 mg/mL
Tabletoral500 mg/1
Tabletoral750 mg/1
Liquidintramuscular; intravenous100 mg
Tabletoral
Injectionintramuscular; intravenous100 mg/mL
Tabletoral500 mg
Tablet, film coatedoral500 mg/1
Tablet, film coatedoral750 mg/1
Tabletoral750 mg
Prices
Unit descriptionCostUnit
Robaxin-750 750 mg tablet2.48USD tablet
Robaxin 100 mg/ml vial2.2USD ml
Robaxin-750 tablet1.99USD tablet
Robaxin 500 mg tablet1.68USD tablet
Methocarbamol powder0.95USD g
Methocarbamol 750 mg tablet0.49USD tablet
Methocarbamol 500 mg tablet0.38USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point93 °CPhysProp
water solubility7200 mg/L (at 25 °C)CHEM INSPECT TEST INST (1992)
logP0.61CHEM INSPECT TEST INST (1992)
Predicted Properties
PropertyValueSource
Water Solubility4.21 mg/mLALOGPS
logP0.63ALOGPS
logP0.45ChemAxon
logS-1.8ALOGPS
pKa (Strongest Acidic)13.6ChemAxon
pKa (Strongest Basic)-3.4ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area91.01 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity59.07 m3·mol-1ChemAxon
Polarizability24.28 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis ReferenceNot Available
General References
  1. Sica DA, Comstock TJ, Davis J, Manning L, Powell R, Melikian A, Wright G: Pharmacokinetics and protein binding of methocarbamol in renal insufficiency and normals. Eur J Clin Pharmacol. 1990;39(2):193-4. [PubMed:2253675 ]
External Links
ATC CodesM03BA03M03BA53M03BA73
AHFS Codes
  • 12:20.00
PDB EntriesNot Available
FDA labelDownload (121 KB)
MSDSNot Available
Interactions
Drug Interactions
Drug
AzelastineMethocarbamol may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Methocarbamol.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Methocarbamol.
BuprenorphineMethocarbamol may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Methocarbamol.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Methocarbamol.
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Methocarbamol.
EperisoneThe risk or severity of adverse effects can be increased when Eperisone is combined with Methocarbamol.
EthanolMethocarbamol may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
HydrocodoneMethocarbamol may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Methocarbamol.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Methocarbamol.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Methocarbamol.
MethotrimeprazineMethocarbamol may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
MetyrosineMethocarbamol may increase the sedative activities of Metyrosine.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Methocarbamol.
MirtazapineMethocarbamol may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Methocarbamol.
OrphenadrineMethocarbamol may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
ParaldehydeMethocarbamol may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParoxetineThe risk or severity of adverse effects can be increased when Methocarbamol is combined with Paroxetine.
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Methocarbamol.
PramipexoleMethocarbamol may increase the sedative activities of Pramipexole.
PyridostigmineThe therapeutic efficacy of Pyridostigmine can be decreased when used in combination with Methocarbamol.
RopiniroleMethocarbamol may increase the sedative activities of Ropinirole.
RotigotineMethocarbamol may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Methocarbamol.
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Methocarbamol.
SuvorexantMethocarbamol may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Methocarbamol.
ThalidomideMethocarbamol may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
ZolpidemMethocarbamol may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Food Interactions
  • Avoid alcohol.
  • Take without regard to meals.

Targets

Kind
Protein
Organism
Human
Pharmacological action
no
Actions
inhibitor
General Function:
Zinc ion binding
Specific Function:
Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea.
Gene Name:
CA1
Uniprot ID:
P00915
Molecular Weight:
28870.0 Da
References
  1. Parr JS, Khalifah RG: Inhibition of carbonic anhydrases I and II by N-unsubstituted carbamate esters. J Biol Chem. 1992 Dec 15;267(35):25044-50. [PubMed:1460006 ]
Comments
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Drug created on June 13, 2005 07:24 / Updated on January 06, 2014 14:00