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Identification
NameCiprofloxacin
Accession NumberDB00537  (APRD00424, EXPT00999)
TypeSmall Molecule
GroupsApproved, Investigational
Description

A broad-spectrum antimicrobial carboxyfluoroquinoline. [PubChem]

Structure
Thumb
Synonyms
SynonymLanguageCode
1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acidNot AvailableNot Available
1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acidNot AvailableNot Available
1-Cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acidNot AvailableNot Available
1-CYCLOPROPYL-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydroquinoline-3-carboxylic acidNot AvailableNot Available
1-Cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acidNot AvailableNot Available
1-Cyclopropyl-6-fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acidNot AvailableNot Available
1-Cyclopropyl-6-fluoro-7-hexahydro-1-pyrazinyl-4-oxo-1,4-dihydro-3-quinolinecarboxylic acidNot AvailableNot Available
CiprofloxacinNot AvailableNot Available
CiprofloxacineNot AvailableNot Available
CiprofloxacinoNot AvailableNot Available
CiprofloxacinumNot AvailableNot Available
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Ciloxanointment3.33 mg/gophthalmicAlcon Laboratories, Inc.1998-06-02Not AvailableUs
Ciloxansolution3.5 mg/mLophthalmicAlcon Laboratories, Inc.1991-01-15Not AvailableUs
Proquin XRtablet, film coated, extended release500 mgoralDepomed, Inc.2005-10-01Not AvailableUs
Ciprofloxacin Hydrochloridesolution3.5 mg/mLophthalmicSTAT Rx USA LLC2004-05-07Not AvailableUs
Ciprofloxacin Hydrochloridesolution3.5 mg/mLophthalmicRebel Distributors Corp1990-12-31Not AvailableUs
Ciprofloxacin Oticsolution/ drops.5 mg/.25mLauricular (otic)Xspire Pharma2012-08-27Not AvailableUs
Ciprotablet, film coated500 mgoralBayer Health Care Pharmaceuticals Inc.1987-10-22Not AvailableUs
Ciprotablet, film coated250 mgoralBayer Health Care Pharmaceuticals Inc.1987-10-22Not AvailableUs
Ciprosolution, concentrate2 mg/mLintravenousBayer Health Care Pharmaceuticals Inc.2009-04-22Not AvailableUs
CiprokitBayer Health Care Pharmaceuticals Inc.1997-09-26Not AvailableUs
CiprokitBayer Health Care Pharmaceuticals Inc.1997-09-26Not AvailableUs
Ciprotablet, film coated, extended release212.6; 287.5 mg/1; 1oralBayer Health Care Pharmaceuticals Inc.2012-10-01Not AvailableUs
Ciprotablet, film coated, extended release452.2; 574.9 mg/1; 1oralBayer Health Care Pharmaceuticals Inc.2012-10-01Not AvailableUs
Ciloxansolution3.5 mg/mLophthalmicPhysicians Total Care, Inc.1995-07-10Not AvailableUs
Ciprosuspension9; 2; 10 mg/mL; mg/mL; mg/mLauricular (otic)Physicians Total Care, Inc.2009-02-12Not AvailableUs
Ciprofloxacin Hydrochloridesolution3.5 mg/mLophthalmicFalcon Pharmaceuticals, Ltd.2004-05-07Not AvailableUs
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Ciprofloxacininjection, solution, concentrate10 mg/mLintravenousPfizer Labs, Division of Pfizer Inc2009-09-11Not AvailableUs
Ciprofloxacininjection, solution, concentrate10 mg/mLintravenousPfizer Labs, Division of Pfizer Inc2009-09-11Not AvailableUs
Ciprofloxacininjection, solution2 mg/mLintravenousPfizer Labs, Division of Pfizer Inc2009-09-11Not AvailableUs
Ciprofloxacininjection, solution2 mg/mLintravenousPfizer Labs, Division of Pfizer Inc2009-09-11Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralWest ward Pharmaceutical Corp2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated250 mgoralWest ward Pharmaceutical Corp2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralWest ward Pharmaceutical Corp2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated750 mgoralWest ward Pharmaceutical Corp2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated250 mgoralIVAX Pharmaceuticals, Inc.2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralIVAX Pharmaceuticals, Inc.2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated750 mgoralIVAX Pharmaceuticals, Inc.2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralKAISER FOUNDATION HOSPITALS2010-02-26Not AvailableUs
Ciprofloxacin Hydrochloridetablet500 mgoralKAISER FOUNDATION HOSPITALS2011-06-23Not AvailableUs
Ciprofloxacintablet, film coated, extended release212.6; 287.5 mg/1; mgoralMylan Pharmaceuticals Inc.2007-03-22Not AvailableUs
Ciprofloxacintablet, film coated, extended release425.2; 574.9 mg/1; mgoralMylan Pharmaceuticals Inc.2007-03-22Not AvailableUs
Ciprofloxacintablet, film coated250 mgoralMylan Pharmaceuticals Inc.2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralMylan Pharmaceuticals Inc.2004-06-09Not AvailableUs
Ciprofloxacininjection, solution, concentrate200 mg/20mLintravenousHospira, Inc.2006-08-28Not AvailableUs
Ciprofloxacininjection, solution2 mg/mLintravenousHospira, Inc.2008-03-18Not AvailableUs
Ciprofloxacininjection, solution2 mg/mLintravenousHospira, Inc.2008-03-18Not AvailableUs
Ciprofloxacininjection, solution, concentrate400 mg/40mLintravenousHospira, Inc.2006-08-28Not AvailableUs
Ciprofloxacininjection2 mg/mLintravenousSandoz Inc2008-03-24Not AvailableUs
Ciprofloxacininjection2 mg/mLintravenousSandoz Inc2008-03-24Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralMajor Pharmaceuticals2014-06-09Not AvailableUs
Ciprofloxacin Extended-Releasetablet, film coated, extended release287.5; 212.6 mg/1; mgoralPar Pharmaceutical, Inc.2011-08-05Not AvailableUs
Ciprofloxacin Extended-Releasetablet, film coated, extended release574.9; 425.2 mg/1; mgoralPar Pharmaceutical, Inc.2011-08-05Not AvailableUs
Ciprofloxacintablet500 mgoralBlenheim Pharmacal, Inc.2012-06-27Not AvailableUs
Ciprofloxacintablet250 mgoralBlenheim Pharmacal, Inc.2010-05-17Not AvailableUs
Ciprofloxacintablet, film coated250 mgoralBlenheim Pharmacal, Inc.2010-05-17Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralBlenheim Pharmacal, Inc.2010-05-17Not AvailableUs
Ciprofloxacin Hydrochloridetablet500 mgoralBlenheim Pharmacal, Inc.2010-05-17Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralBlenheim Pharmacal, Inc.2010-05-17Not AvailableUs
Ciprofloxacintablet500 mgoralBlenheim Pharmacal, Inc.2010-05-17Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralHHS/Program Support Center/Supply Service Center2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralHHS/Program Support Center/Supply Service Center2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralHHS/Program Support Center/Supply Service Center2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralHHS/Program Support Center/Supply Service Center2011-12-22Not AvailableUs
Ciprofloxacintablet, film coated250 mgoralAurolife Pharma LLC2009-08-01Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralAurolife Pharma LLC2009-08-01Not AvailableUs
Ciprofloxacintablet, film coated250 mgoralActavis Pharma, Inc.2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralActavis Pharma, Inc.2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated750 mgoralActavis Pharma, Inc.2004-06-09Not AvailableUs
Ciprofloxacinsolution/ drops3.5 mg/mLtopicalPACK Pharmaceuticals, LLC2008-03-20Not AvailableUs
Ciprofloxacinsolution/ drops3 mg/mLophthalmic; topicalPACK Pharmaceuticals, LLC2010-09-15Not AvailableUs
Ciprofloxacintablet250 mgoralPACK Pharmaceuticals, LLC2004-09-10Not AvailableUs
Ciprofloxacintablet500 mgoralPACK Pharmaceuticals, LLC2004-09-10Not AvailableUs
Ciprofloxacintablet750 mgoralPACK Pharmaceuticals, LLC2004-09-10Not AvailableUs
Ciprofloxacintablet500 mgoralSTAT Rx USA LLC2004-09-10Not AvailableUs
Ciprofloxacintablet, film coated750 mgoralSTAT Rx USA LLC2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated250 mgoralNorth Star Rx Llc2007-04-26Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralNorth Star Rx Llc2007-04-26Not AvailableUs
Ciprofloxacintablet, film coated750 mgoralNorth Star Rx Llc2007-04-26Not AvailableUs
Ciprofloxacinsolution/ drops3 mg/mLophthalmicAkorn Inc.2009-07-24Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralRebel Distributors Corp.2004-06-09Not AvailableUs
Ciprofloxacintablet250 mgoralRebel Distributors Corp2003-08-19Not AvailableUs
Ciprofloxacininjection10 mg/mLintravenousRebel Distributors Corp2006-08-28Not AvailableUs
Ciprofloxacininjection, solution, concentrate400 mg/40mLintravenousRebel Distributors Corp2009-12-08Not AvailableUs
Ciprofloxacinsolution/ drops3.5 mg/mLophthalmicBausch & Lomb Incorporated2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralBlu Pharmaceuticals, LLC2004-06-09Not AvailableUs
Ciprofloxacininjection2 mg/mLintravenousSagent Pharmaceuticals2008-03-24Not AvailableUs
Ciprofloxacintablet500 mgoralAidarex Pharmaceuticals LLC2004-09-10Not AvailableUs
Ciprofloxacintablet750 mgoralAidarex Pharmaceuticals LLC2004-09-10Not AvailableUs
Ciprofloxacintablet250 mgoralAidarex Pharmaceuticals LLC2004-09-10Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralLake Erie Medical DBA Quality Care Products LLC2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated250 mgoralLake Erie Medical DBA Quality Care Products LLC2004-06-09Not AvailableUs
Ciprofloxacintablet500 mgoralLake Erie Medical DBA Quality Care Products LLC2004-09-10Not AvailableUs
Ciprofloxacintablet, film coated250 mgoralLake Erie Medical DBA Quality Care Products LLC2013-05-02Not AvailableUs
Ciprofloxacininjection, solution2 mg/mLintravenousClaris Lifesciences Inc.2008-08-04Not AvailableUs
Ciprofloxacininjection, solution2 mg/mLintravenousClaris Lifesciences Inc.2008-08-04Not AvailableUs
Ciprofloxacininjection, solution, concentrate10 mg/mLintravenousClaris Lifesciences Inc.2009-09-17Not AvailableUs
Ciprofloxacininjection, solution, concentrate10 mg/mLintravenousClaris Lifesciences Inc.2009-09-17Not AvailableUs
Ciprofloxacininjection, solution2 mg/mLintravenousClaris Lifesciences Inc.2008-08-04Not AvailableUs
Ciprofloxacininjection, solution2 mg/mLintravenousClaris Lifesciences Inc.2014-08-01Not AvailableUs
Ciprofloxacinsolution/ drops3.5 mg/mLophthalmicPharma Force, Inc.2008-01-16Not AvailableUs
Ciprofloxacinsolution/ drops3 mg/mLophthalmic; topicalRebel Distributors Corp2005-01-21Not AvailableUs
Ciprofloxacintablet, film coated250 mgoralAv Kare, Inc.2014-06-16Not AvailableUs
Ciprofloxacin Hydrochloridetablet500 mgoralApothecary Shop Wholesale Inc.2011-07-01Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralPd Rx Pharmaceuticals, Inc.2004-06-09Not AvailableUs
Ciprofloxacintablet250 mgoralPd Rx Pharmaceuticals, Inc.2004-09-10Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralPd Rx Pharmaceuticals, Inc.2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralPd Rx Pharmaceuticals, Inc.2009-10-10Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralAphena Pharma Solutions Tennessee, Llc2009-08-01Not AvailableUs
Ciprofloxacin Hydrochloridetablet250 mgoralREMEDYREPACK INC.2010-10-11Not AvailableUs
Ciprofloxacin Hydrochloridetablet500 mgoralREMEDYREPACK INC.2010-10-18Not AvailableUs
Ciprofloxacin Hydrochloridetablet500 mgoralREMEDYREPACK INC.2010-11-22Not AvailableUs
Ciprofloxacin Hydrochloridetablet, film coated500 mgoralREMEDYREPACK INC.2011-04-20Not AvailableUs
Ciprofloxacin Hydrochloridetablet250 mgoralREMEDYREPACK INC.2011-05-05Not AvailableUs
Ciprofloxacin Hydrochloridetablet500 mgoralREMEDYREPACK INC.2011-06-08Not AvailableUs
Ciprofloxacin Hydrochloridetablet500 mgoralREMEDYREPACK INC.2011-06-08Not AvailableUs
Ciprofloxacin Hydrochloridetablet250 mgoralREMEDYREPACK INC.2011-07-29Not AvailableUs
Ciprofloxacin Hydrochloridetablet500 mgoralREMEDYREPACK INC.2011-08-04Not AvailableUs
Ciprofloxacin Hydrochloridetablet, film coated500 mgoralREMEDYREPACK INC.2011-03-15Not AvailableUs
Ciprofloxacin Hydrochloridetablet, film coated500 mgoralREMEDYREPACK INC.2011-05-24Not AvailableUs
Ciprofloxacin Hydrochloridetablet500 mgoralREMEDYREPACK INC.2013-07-24Not AvailableUs
Ciprofloxacin Hydrochloridetablet500 mgoralREMEDYREPACK INC.2013-07-24Not AvailableUs
Ciprofloxacin Hydrochloridetablet500 mgoralREMEDYREPACK INC.2013-07-30Not AvailableUs
Ciprofloxacin Hydrochloridetablet500 mgoralREMEDYREPACK INC.2011-12-07Not AvailableUs
Ciprofloxacin Hydrochloridetablet500 mgoralREMEDYREPACK INC.2013-07-24Not AvailableUs
Ciprofloxacintablet250 mgoralREMEDYREPACK INC.2011-05-23Not AvailableUs
Ciprofloxacin Hydrochloridetablet500 mgoralREMEDYREPACK INC.2011-12-12Not AvailableUs
Ciprofloxacintablet250 mgoralLake Erie Medical DBA Quality Care Products LLC2012-02-29Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralLake Erie Medical DBA Quality Care Products LLC2010-11-03Not AvailableUs
Ciprofloxacinsolution/ drops3 mg/mLophthalmic; topicalLake Erie Medical DBA Quality Care Products LLC2005-01-21Not AvailableUs
Ciprofloxacinsolution/ drops3 mg/mLophthalmic; topicalHi Tech Pharmacal Co., Inc.2005-01-21Not AvailableUs
Ciprofloxacintablet250 mgoralUnit Dose Services2004-09-10Not AvailableUs
Ciprofloxacinsolution/ drops3 mg/mLophthalmic; topicalUnit Dose Services2005-01-21Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralUnit Dose Services2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralMylan Institutional Inc.2011-04-11Not AvailableUs
Ciprofloxacintablet500 mgoralNorthwind Pharmaceuticals2014-06-01Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralREMEDYREPACK INC.2013-03-14Not AvailableUs
Ciprofloxacintablet, film coated250 mgoralREMEDYREPACK INC.2013-05-02Not AvailableUs
Ciprofloxacintablet, film coated250 mgoralREMEDYREPACK INC.2013-05-02Not AvailableUs
Ciprofloxacintablet, film coated250 mgoralREMEDYREPACK INC.2013-07-16Not AvailableUs
Ciprofloxacintablet, film coated250 mgoralREMEDYREPACK INC.2013-05-02Not AvailableUs
Ciprofloxacinsolution/ drops3.5 mg/mLtopicalREMEDYREPACK INC.2013-05-31Not AvailableUs
Ciprofloxacinsolution/ drops3.5 mg/mLtopicalREMEDYREPACK INC.2013-04-23Not AvailableUs
Ciprofloxacinsolution/ drops3.5 mg/mLtopicalREMEDYREPACK INC.2013-11-18Not AvailableUs
Ciprofloxacinsolution/ drops3 mg/mLophthalmicREMEDYREPACK INC.2013-12-17Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralGen Source Rx2007-04-26Not AvailableUs
Ciprofloxacinsolution/ drops3 mg/mLophthalmic; topicalH.J. Harkins Company, Inc.2005-01-21Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralH.J. Harkins Company, Inc.2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated750 mgoralH.J. Harkins Company, Inc.2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated250 mgoralH.J. Harkins Company, Inc.2004-06-09Not AvailableUs
Ciprofloxacintablet, coated500 mgoralTestpak Holding Company2009-10-10Not AvailableUs
Ciprofloxacin Hydrochloridetablet, coated500 mgoralTestpak Holding Company2009-12-03Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralAphena Pharma Solutions New Jersey, Llc2009-08-01Not AvailableUs
Ciprofloxacin Hydrochloridetablet500 mgoralState of Florida DOH Central Pharmacy2009-07-01Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralState of Florida DOH Central Pharmacy2009-07-01Not AvailableUs
Ciprofloxacintablet500 mgoralState of Florida DOH Central Pharmacy2014-11-01Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralA S Medication Solutions Llc2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated250 mgoralA S Medication Solutions Llc2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralA S Medication Solutions Llc2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated250 mgoralA S Medication Solutions Llc2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralPhysicians Total Care, Inc.2003-09-12Not AvailableUs
Ciprofloxacintablet, film coated250 mgoralPhysicians Total Care, Inc.2003-08-19Not AvailableUs
Ciprofloxacintablet, film coated750 mgoralPhysicians Total Care, Inc.2004-03-17Not AvailableUs
Ciprofloxacinsolution/ drops3 mg/mLophthalmic; topicalPhysicians Total Care, Inc.2004-08-09Not AvailableUs
Ciprofloxacintablet, film coated100 mgoralDr Reddy's Laboratories2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated250 mgoralDr Reddy's Laboratories2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralDr Reddy's Laboratories2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated750 mgoralDr Reddy's Laboratories2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated, extended release212.6; 287.5 mg/1; mgoralDr. Reddy's Laboratories Limited2007-03-26Not AvailableUs
Ciprofloxacintablet, film coated, extended release425.2; 574.9 mg/1; mgoralDr. Reddy's Laboratories Limited2007-10-31Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralCardinal Health2004-08-19Not AvailableUs
Ciprofloxacintablet, film coated250 mgoralCardinal Health2004-08-19Not AvailableUs
Ciprofloxacintablet, film coated250 mgoralCardinal Health2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralCardinal Health2012-06-29Not AvailableUs
Ciprofloxacin Hydrochloridetablet500 mgoralCardinal Health2009-10-09Not AvailableUs
Ciprofloxacin Hydrochloridetablet250 mgoralCardinal Health2009-10-09Not AvailableUs
Ciprofloxacin Hydrochloridetablet750 mgoralCardinal Health2009-10-09Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralPd Rx Pharmaceuticals, Inc.2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated250 mgoralPd Rx Pharmaceuticals, Inc.2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated750 mgoralPd Rx Pharmaceuticals, Inc.2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralClinical Solutions Wholesale2004-06-09Not AvailableUs
Ciprofloxacintablet250 mgoralClinical Solutions Wholesale2004-09-10Not AvailableUs
Ciprofloxacinsolution/ drops3 mg/mLophthalmic; topicalClinical Solutions Wholesale2005-01-21Not AvailableUs
Ciprofloxacintablet, film coated750 mgoralHikma Pharmaceutical2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralHikma Pharmaceutical2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated250 mgoralHikma Pharmaceutical2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralGolden State Medical Supply, Inc2014-11-03Not AvailableUs
Ciprofloxacintablet, film coated250 mgoralGolden State Medical Supply, Inc.2004-06-092015-08-30Us
Ciprofloxacintablet, film coated500 mgoralGolden State Medical Supply, Inc.2004-06-092015-08-30Us
Ciprofloxacintablet, film coated250 mgoralApotex Corp2005-04-19Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralApotex Corp2005-04-19Not AvailableUs
Ciprofloxacintablet, film coated750 mgoralApotex Corp2008-03-13Not AvailableUs
Ciprofloxacintablet250 mgoralSt Marys Medical Park Pharmacy2014-01-16Not AvailableUs
Ciprofloxacintablet, film coated250 mgoralCarlsbad Technology, Inc.2009-10-10Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralCarlsbad Technology, Inc.2009-10-10Not AvailableUs
Ciprofloxacintablet, film coated750 mgoralCarlsbad Technology, Inc.2009-10-10Not AvailableUs
Ciprofloxacintablet250 mgoralREMEDYREPACK INC.2014-12-11Not AvailableUs
Ciprofloxacintablet250 mgoralREMEDYREPACK INC.2014-11-18Not AvailableUs
Ciprofloxacintablet250 mgoralDIRECT RX2014-01-01Not AvailableUs
Ciprofloxacinsolution/ drops3.5 mgtopicalDIRECT RX2014-01-01Not AvailableUs
Ciprofloxacintablet, film coated, extended release425.2; 574.9 mg/1; mgoralWatson Pharma, Inc.2010-11-30Not AvailableUs
Ciprofloxacintablet, film coated, extended release212.6; 287.5 mg/1; mgoralWatson Pharma, Inc.2010-11-30Not AvailableUs
Ciprofloxacinsolution/ drops3 mg/mLophthalmic; topicalProficient Rx LP2004-08-09Not AvailableUs
Ciprofloxacintablet500 mgoralProficient Rx LP2004-09-10Not AvailableUs
Ciprofloxacintablet250 mgoralProficient Rx LP2004-09-10Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralProficient Rx LP2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated250 mgoralRanbaxy Pharmaceuticals Inc.2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralRanbaxy Pharmaceuticals Inc.2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated750 mgoralRanbaxy Pharmaceuticals Inc.2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated250 mgoralbryant ranch prepack2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralbryant ranch prepack2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated750 mgoralbryant ranch prepack2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2012-11-20Not AvailableUs
Ciprofloxacintablet, film coated250 mgoralReady Meds2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralReady Meds2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated250 mgoralAurobindo Pharma Limited2007-04-26Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralAurobindo Pharma Limited2007-04-26Not AvailableUs
Ciprofloxacintablet, film coated750 mgoralAurobindo Pharma Limited2007-04-26Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralMed Vantx, Inc.2007-04-26Not AvailableUs
Ciprofloxacin Hydrochloridetablet500 mgoralMed Vantx, Inc.2004-06-09Not AvailableUs
Ciprofloxacin Hydrochloridetablet500 mgoralRed Pharm Drug Inc.2011-04-04Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralRed Pharm Drug Inc.2009-08-01Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralRed Pharm Drug Inc.2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralRed Pharm Drug Inc.2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated250 mgoralRed Pharm Drug Inc.2004-06-09Not AvailableUs
Ciprofloxacintablet250 mgoralRed Pharm Drug Inc.2004-09-10Not AvailableUs
Ciprofloxacintablet, film coated250 mgoralAmerican Health Packaging2013-07-08Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralAmerican Health Packaging2013-07-08Not AvailableUs
Ciprofloxacintablet, film coated750 mgoralAmerican Health Packaging2013-07-08Not AvailableUs
CiprofloxacinkitLupin Pharmaceuticals, Inc.2014-06-06Not AvailableUs
CiprofloxacinkitLupin Pharmaceuticals, Inc.2014-06-06Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralLegacy Pharmaceutical Packaging2011-04-12Not AvailableUs
Ciprofloxacintablet, film coated250 mgoralPreferred Pharmaceuticals, Inc.2011-06-14Not AvailableUs
Ciprofloxacintablet500 mgoralPreferred Pharmaceuticals, Inc.2011-06-10Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralPreferred Pharmaceuticals, Inc.2004-06-09Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralPreferred Pharmaceuticals, Inc.2014-11-12Not AvailableUs
Ciprofloxacintablet250 mgoralPreferred Pharmaceuticals, Inc.2015-01-29Not AvailableUs
Ciprofloxacintablet, film coated500 mgoralPreferred Pharmaceuticals, Inc.2014-10-21Not AvailableUs
Ciprofloxacinsolution/ drops3.5 mg/mLtopicalPreferred Pharmaceuticals, Inc.2014-07-03Not AvailableUs
Ciprofloxacintablet, film coated250 mgoralPreferred Pharmaceuticals, Inc.2012-11-21Not AvailableUs
Ciprofloxacinsolution/ drops3 mg/mLophthalmic; topicalPreferred Pharmaceuticals, Inc.2012-01-12Not AvailableUs
Ciprofloxacintablet500 mgoralLife Line Home Care Services, Inc.2012-02-06Not AvailableUs
Over the Counter ProductsNot Available
International Brands
NameCompany
BacquinorNot Available
BaycipNot Available
CifloxNot Available
CifloxinNot Available
CiprinolNot Available
CiprobayNot Available
CiprocinolNot Available
CiprodarNot Available
CiproxanNot Available
CiproxinNot Available
FlociprinNot Available
ProquinNot Available
Brand mixtures
Brand NameIngredients
Cipro HC Otic SuspensionCiprofloxacin hydrochloride + Hydrocortisone
CiprodexCiprofloxacin hydrochloride + Dexamethasone
CiproquinolCiprofloxacin hydrochloride + Hydrocortisone
Salts
Name/CASStructureProperties
Ciprofloxacin Hydrochloride
93107-08-5
Thumb
  • InChI Key: DIOIOSKKIYDRIQ-UHFFFAOYSA-N
  • Monoisotopic Mass: 367.109897401
  • Average Mass: 367.802
DBSALT000293
Categories
CAS number85721-33-1
WeightAverage: 331.3415
Monoisotopic: 331.133219662
Chemical FormulaC17H18FN3O3
InChI KeyMYSWGUAQZAJSOK-UHFFFAOYSA-N
InChI
InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24)
IUPAC Name
1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
SMILES
OC(=O)C1=CN(C2CC2)C2=CC(N3CCNCC3)=C(F)C=C2C1=O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as quinoline carboxylic acids. These are quinolines in which the quinoline ring system is substituted by a carboxyl group at one or more positions.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassQuinolines and derivatives
Sub ClassQuinoline carboxylic acids
Direct ParentQuinoline carboxylic acids
Alternative Parents
Substituents
  • Quinoline-3-carboxylic acid
  • N-arylpiperazine
  • Fluoroquinolone
  • Dihydroquinolone
  • Aminoquinoline
  • Dihydroquinoline
  • Pyridine carboxylic acid or derivatives
  • Pyridine carboxylic acid
  • Dialkylarylamine
  • Fluorobenzene
  • Benzenoid
  • Pyridine
  • Piperazine
  • 1,4-diazinane
  • Aryl halide
  • Aryl fluoride
  • Heteroaromatic compound
  • Vinylogous amide
  • Tertiary amine
  • Azacycle
  • Secondary amine
  • Monocarboxylic acid or derivatives
  • Secondary aliphatic amine
  • Carboxylic acid
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Organofluoride
  • Organohalogen compound
  • Carbonyl group
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of the following infections caused by susceptible organisms: urinary tract infections, acute uncomplicated cystitis, chronic bacterial prostatitis, lower respiratory tract infections, acute sinusitis, skin and skin structure infections, bone and joint infections, complicated intra-abdominal infections (used in combination with metronidazole), infectious diarrhea, typhoid fever (enteric fever), uncomplicated cervical and urethral gonorrhea, and inhalational anthrax (post-exposure).
PharmacodynamicsCiprofloxacin is a broad-spectrum antiinfective agent of the fluoroquinolone class. Ciprofloxacin has in vitro activity against a wide range of gram-negative and gram-positive microorganisms. The mechanism of action of quinolones, including ciprofloxacin, is different from that of other antimicrobial agents such as beta-lactams, macrolides, tetracyclines, or aminoglycosides; therefore, organisms resistant to these drugs may be susceptible to ciprofloxacin. There is no known cross-resistance between ciprofloxacin and other classes of antimicrobials. Notably the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian.
Mechanism of actionThe bactericidal action of ciprofloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, strand supercoiling repair, and recombination.
AbsorptionRapidly and well absorbed from the gastrointestinal tract after oral administration. The absolute bioavailability is approximately 70% with no substantial loss by first pass metabolism.
Volume of distributionNot Available
Protein binding20 to 40%
Metabolism

Hepatic. Four metabolites have been identified in human urine which together account for approximately 15% of an oral dose. The metabolites have antimicrobial activity, but are less active than unchanged ciprofloxacin.

Route of eliminationApproximately 40 to 50% of an orally administered dose is excreted in the urine as unchanged drug.
Half life4 hours
Clearance
  • Renal cl=300 mL/min
ToxicityThe major adverse effect seen with use of is gastrointestinal irritation, common with many antibiotics.
Affected organisms
  • Enteric bacteria and other eubacteria
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal AbsorptionNot AvailableNot Available
Blood Brain BarrierNot AvailableNot Available
Caco-2 permeableNot AvailableNot Available
P-glycoprotein substrateNot AvailableNot Available
P-glycoprotein inhibitor INot AvailableNot Available
P-glycoprotein inhibitor IINot AvailableNot Available
Renal organic cation transporterNot AvailableNot Available
CYP450 2C9 substrateNot AvailableNot Available
CYP450 2D6 substrateNot AvailableNot Available
CYP450 3A4 substrateNot AvailableNot Available
CYP450 1A2 substrateNot AvailableNot Available
CYP450 2C9 substrateNot AvailableNot Available
CYP450 2D6 substrateNot AvailableNot Available
CYP450 2C19 substrateNot AvailableNot Available
CYP450 3A4 substrateNot AvailableNot Available
CYP450 inhibitory promiscuityNot AvailableNot Available
Ames testNot AvailableNot Available
CarcinogenicityNot AvailableNot Available
BiodegradationNot AvailableNot Available
Rat acute toxicityNot AvailableNot applicable
hERG inhibition (predictor I)Not AvailableNot Available
hERG inhibition (predictor II)Not AvailableNot Available
Pharmacoeconomics
Manufacturers
  • Bayer healthcare pharmaceuticals inc
  • Bayer pharmaceuticals corp
  • App pharmaceuticals llc
  • Bedford laboratories
  • Claris lifesciences ltd
  • Hospira inc
  • Teva parenteral medicines inc
  • West ward pharmaceutical corp
  • Hikma farmaceutica (portugal) sa
  • Acs dobfar info sa
  • Baxter healthcare corp
  • Bedford laboratories div ben venue laboratories inc
  • Alcon inc
  • Akorn inc
  • Bausch and lomb pharmaceuticals inc
  • Fdc ltd
  • Hitech pharmacal corp
  • Nexus pharmaceuticals inc
  • Novex pharma
  • Pharmaforce inc
  • Wraser pharmaceuticals llc
  • Depomed inc
  • Apotex inc
  • Aurobindo pharma ltd
  • Barr laboratories inc
  • Carlsbad technology inc
  • Dr reddys laboratories ltd
  • Hikma pharmaceuticals
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Mylan pharmaceuticals inc
  • Nostrum laboratories inc
  • Pliva inc
  • Ranbaxy pharmaceuticals inc
  • Sandoz inc
  • Taro pharmaceuticals usa inc
  • Teva pharmaceuticals usa inc
  • Unique pharmaceutical laboratories
  • Watson laboratories inc
  • Allergan inc
Packagers
Dosage forms
FormRouteStrength
Injectionintravenous10 mg/mL
Injectionintravenous2 mg/mL
Injection, solutionintravenous2 mg/mL
Injection, solution, concentrateintravenous10 mg/mL
Injection, solution, concentrateintravenous200 mg/20mL
Injection, solution, concentrateintravenous400 mg/40mL
Kit
Ointmentophthalmic3.33 mg/g
Solutionophthalmic3.5 mg/mL
Solution, concentrateintravenous2 mg/mL
Solution/ dropsauricular (otic).5 mg/.25mL
Solution/ dropsophthalmic3 mg/mL
Solution/ dropsophthalmic3.5 mg/mL
Solution/ dropsophthalmic; topical3 mg/mL
Solution/ dropstopical3.5 mg
Solution/ dropstopical3.5 mg/mL
Suspensionauricular (otic)9; 2; 10 mg/mL; mg/mL; mg/mL
Tabletoral250 mg
Tabletoral500 mg
Tabletoral750 mg
Tablet, coatedoral500 mg
Tablet, film coatedoral100 mg
Tablet, film coatedoral250 mg
Tablet, film coatedoral500 mg
Tablet, film coatedoral750 mg
Tablet, film coated, extended releaseoral212.6; 287.5 mg/1; 1
Tablet, film coated, extended releaseoral212.6; 287.5 mg/1; mg
Tablet, film coated, extended releaseoral287.5; 212.6 mg/1; mg
Tablet, film coated, extended releaseoral425.2; 574.9 mg/1; mg
Tablet, film coated, extended releaseoral452.2; 574.9 mg/1; 1
Tablet, film coated, extended releaseoral500 mg
Tablet, film coated, extended releaseoral574.9; 425.2 mg/1; mg
Prices
Unit descriptionCostUnit
Cipro 400 mg Solution 40ml Vial259.99USD vial
Floxin Otic 0.3% Solution 10ml Bottle142.91USD bottle
Cipro 500 mg/5ml(10%) Suspension 100ml Bottle136.75USD bottle
Cipro HC 0.2-1% Suspension 10ml Bottle131.54USD bottle
Cipro 250 mg/5ml(5%) Suspension 100ml Bottle116.8USD bottle
Ocuflox 0.3% Solution 10ml Bottle106.09USD bottle
Ciprofloxacin HCl 0.3% Solution 10ml Bottle98.22USD bottle
Ciloxan 0.3% Ointment 3.5 gm Tube87.49USD tube
Floxin Otic 0.3% Solution 5ml Bottle86.49USD bottle
Ciloxan 0.3% Solution 5ml Bottle68.33USD bottle
Ocuflox 0.3% Solution 5ml Bottle57.32USD bottle
Ciprofloxacin HCl 0.3% Solution 5ml Bottle49.2USD bottle
ProQuin XR 3 500 mg 24 Hour tablet Disp Pack39.99USD disp
Ciprofloxacin HCl 0.3% Solution 2.5ml Bottle26.03USD bottle
Ciloxan 0.3% eye drops13.33USD ml
Ciprofloxacin 0.3% eye drop12.96USD ml
Cipro hc otic suspension12.65USD ml
Proquin xr 500 mg tablet12.18USD tablet
Cipro xr 1000 mg tablet11.91USD tablet
Ciprofloxacin-Ciproflox HCl 1000 mg 24 Hour tablet11.6USD tablet
Ocuflox 0.3% eye drops11.35USD ml
ProQuin XR 500 mg 24 Hour tablet11.18USD tablet
Ciprofloxacin er 1000 mg tablet11.16USD tablet
Cipro XR 500 mg 24 Hour tablet10.88USD tablet
Cipro XR 1000 mg 24 Hour tablet10.75USD tablet
Cipro xr 500 mg tablet10.46USD tablet
Ciprofloxacin-Ciproflox HCl 500 mg 24 Hour tablet10.19USD tablet
Ciprofloxacin er 500 mg tablet9.8USD tablet
Floxin 400 mg tablet9.55USD tablet
Cetraxal 0.2% ear solution7.14USD each
Floxin 200 mg tablet6.6USD tablet
Cipro 750 mg tablet6.26USD tablet
Cipro 500 mg tablet6.08USD tablet
Ciprofloxacin hcl 750 mg tablet5.65USD tablet
Floxin 300 mg tablet5.61USD tablet
Ciprofloxacin hcl 500 mg tablet5.59USD tablet
Cipro 250 mg tablet5.2USD tablet
Ciprofloxacin hcl 250 mg tablet4.59USD tablet
Floxin otic singles4.28USD each
Ciprofloxacin hcl 100 mg tablet4.17USD tablet
Ciloxan 0.3 % Solution2.18USD ml
Ciprofloxacin hcl powder1.29USD g
Apo-Ciproflox 0.3 % Solution1.18USD ml
Pms-Ciprofloxacin 0.3 % Solution1.18USD ml
Cipro i.v. 10 mg/ml vial0.72USD ml
Cipro i.v. 200 mg/100 ml d5w0.16USD ml
Ciprofloxacin 200 mg/20 ml vial0.13USD ml
Ciprofloxacn-d5w 200 mg/100 ml0.03USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
CountryPatent NumberApprovedExpires (estimated)
Canada13309461994-07-262011-07-26
Canada24142712005-09-272021-06-13
United States52867541994-02-152011-02-15
United States77090222001-12-232021-12-23
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point255-257 °CNot Available
water solubility3E+004 mg/L (at 20 °C)NOWARA,A ET AL. (1997)
logP0.28TAKACS-NOVAK,K ET AL. (1992)
pKa6.09TORNIANEN,K ET AL. (1996)
Predicted Properties
PropertyValueSource
Water Solubility1.35 mg/mLALOGPS
logP-0.57ALOGPS
logP-0.81ChemAxon
logS-2.4ALOGPS
pKa (Strongest Acidic)5.76ChemAxon
pKa (Strongest Basic)8.68ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area72.88 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity87.94 m3·mol-1ChemAxon
Polarizability33.12 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis Reference

DrugSyn.org

US4670444
General Reference
  1. Drusano GL, Standiford HC, Plaisance K, Forrest A, Leslie J, Caldwell J: Absolute oral bioavailability of ciprofloxacin. Antimicrob Agents Chemother. 1986 Sep;30(3):444-6. Pubmed
  2. Hilliard JJ, Krause HM, Bernstein JI, Fernandez JA, Nguyen V, Ohemeng KA, Barrett JF: A comparison of active site binding of 4-quinolones and novel flavone gyrase inhibitors to DNA gyrase. Adv Exp Med Biol. 1995;390:59-69. Pubmed
  3. Spivey JM, Cummings DM, Pierson NR: Failure of prostatitis treatment secondary to probable ciprofloxacin-sucralfate drug interaction. Pharmacotherapy. 1996 Mar-Apr;16(2):314-6. Pubmed
  4. Brouwers JR: Drug interactions with quinolone antibacterials. Drug Saf. 1992 Jul-Aug;7(4):268-81. Pubmed
External Links
ATC CodesJ01MA02S01AE03S02AA15S03AA07
AHFS Codes
  • 08:12.18
  • 52:04.04
PDB EntriesNot Available
FDA labelDownload (120 KB)
MSDSDownload (73.9 KB)
Interactions
Drug Interactions
Drug
AcenocoumarolThe quinolone antibiotic, ciprofloxacin, may increase the anticoagulant effect of acenocoumarol.
AluminiumFormation of non-absorbable complexes
AminophyllineCiprofloxacin may increase the effect of aminophylline.
AnisindioneThe quinolone antibiotic, ciprofloxacin, may increase the anticoagulant effect of anisindione.
BendamustineDecreases metabolism, thus INCREASING levels of bendamustine. Decreased conversion of bendamustine to active metabolites. Concurrent administration of Ciproflaxacin or other CYP1A2 inhibitors may also increase the levels of bendamustine into active metabolites.
CaffeineCiprofloxacin may increase the effect and toxicity of caffeine.
CalciumFormation of non-absorbable complexes
Calcium AcetateCalcium salts such as calcium acetate may decrease the absorption of quinolone antibiotics such as ciprofloxacin. Of concern only with oral administration of both agents. Interactions can be minimized by administering oral quinolone at least 2 hours before, or 6 hours after, the dose of an oral calcium supplement. Monitor for decreased therapeutic effects of oral quinolones if administered with oral calcium supplements.
ClozapineCiprofloxacin may increase clozapine serum levels
CyclosporineCiprofloxacin may increase the effect and toxicity of cyclosporine.
DicoumarolThe quinolone antibiotic, ciprofloxacin, may increase the anticoagulant effect of dicumarol.
DihydroxyaluminiumFormation of non-absorbable complexes
DuloxetineCiprofloxacin, a strong CYP1A2 inhibitor, may decrease the metabolism of duloxetine. Monitor for changes in the therapeutic and adverse effects of duloxetine if ciprofloxacin is initiated or discontinued.
DyphyllineCiprofloxacin may increase the effect of dyphylline.
EltrombopagAffects hepatic CYP1A2 metabolism, will increase effect/level of eltrombopag.
EthotoinDecreases the hydantoin effect
FoscarnetIncreased risk of convulsions
IronFormation of non-absorbable complexes
Iron DextranFormation of non-absorbable complexes
LomitapideThe effect of coadminstration of lomipatide with ciproflaxacin, and other moderate CYP3A4 inhibitors (such as aprepitant, amprenavir, atazanavir, ciprofloxacin, crizotinib, darunavir/ritonavir, diltiazem, erythromycin, fluconazole, fosamprenavir, imatinib, verapamil) is unknown. However, as coadministration is likely to increase serum concentrations of lomipatide, concomitant use is contraindicated.
MagnesiumFormation of non-absorbable complexes
Magnesium oxideFormation of non-absorbable complexes
MephenytoinDecreases the hydantoin effect
MethotrexateCiprofloxacine may decrease the metabolism of methotrexate. Monitor for changes adverse effects of methotrexate if ciprofloxacin is initiated.
OxtriphyllineCiprofloxacin may increase the effect of oxtriphylline.
PhenytoinCiprofloxacin may decrease the therapeutic effect of phenytoin.
ProcainamideCiprofloxacin may increase the effect of procainamide.
RamelteonCiprofloxacin increases levels/toxicity of ramelteon
RasagilineCiprofloxacin, a strong CYP1A2 inhibitor, may decrease the metabolism of rasagiline. Monitor for changes in the therapeutic and adverse effects of rasagiline if ciprofloxacin is initiated or discontinued.
RopiniroleCiprofloxacin may increase the effect and toxicity of ropinirole.
SevelamerSevelamer decreases ciprofloxacin bioavailability
SildenafilCiprofloxacin may increase the serum level of sildenafil.
SucralfateFormation of non-absorbable complexes
TacrineThe metabolism of Tacrine, a CYP1A2 substrate, may be reduced by strong CYP1A2 inhibitors such as Ciprofloxacin. Consider modifying therapy to avoid Tacrine toxicity. Monitor the efficacy and toxicity of Tacrine if Ciprofloxacin is initiated, discontinued or if the dose is changed.
TheophyllineCiprofloxacin may increase the effect of theophylline.
ThiothixeneThe strong CYP1A2 inhibitor, Ciprofloxacin, may decrease the metabolism and clearance of Thiothixene, a CYP1A2 substrate. Consider alternate therapy or monitor for changes in Thiothixene therapeutic and adverse effects if Ciprofloxacin is initiated, discontinued or dose changed.
TizanidineCiprofloxacin inhibits the metabolism and clearance of Tizanidine. Concomitant therapy is contraindicated.
WarfarinThe quinolone antibiotic, ciprofloxacin, may increase the anticoagulant effect of warfarin.
ZincFormation of non-absorbable complexes
Food Interactions
  • Avoid excessive quantities of coffee or tea (Caffeine).
  • Avoid milk, calcium containing dairy products, iron, magnesium, zinc, antacids, or aluminum salts 2 hours before or 6 hours after using antacids while on this medication.
  • Take with a full glass of water.
  • Take without regard to meals.

Targets

1. DNA topoisomerase 4 subunit A

Kind: protein

Organism: Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Pharmacological action: yes

Actions: inhibitor

Components

Name UniProt ID Details
DNA topoisomerase 4 subunit A P43702 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Chaudhry U, Ray K, Bala M, Saluja D: Mutation patterns in gyrA and parC genes of ciprofloxacin resistant isolates of Neisseria gonorrhoeae from India. Sex Transm Infect. 2002 Dec;78(6):440-4. Pubmed
  4. Lee JK, Lee YS, Park YK, Kim BS: Mutations in the gyrA and parC genes in ciprofloxacin-resistant clinical isolates of Acinetobacter baumannii in Korea. Microbiol Immunol. 2005;49(7):647-53. Pubmed
  5. Leavis HL, Willems RJ, Top J, Bonten MJ: High-level ciprofloxacin resistance from point mutations in gyrA and parC confined to global hospital-adapted clonal lineage CC17 of Enterococcus faecium. J Clin Microbiol. 2006 Mar;44(3):1059-64. Pubmed
  6. Drlica K, Zhao X: DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev. 1997 Sep;61(3):377-92. Pubmed

2. DNA gyrase subunit A

Kind: protein

Organism: Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Pharmacological action: yes

Actions: inhibitor

Components

Name UniProt ID Details
DNA gyrase subunit A P43700 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Chaudhry U, Ray K, Bala M, Saluja D: Mutation patterns in gyrA and parC genes of ciprofloxacin resistant isolates of Neisseria gonorrhoeae from India. Sex Transm Infect. 2002 Dec;78(6):440-4. Pubmed
  4. Abdelbaqi K, Menard A, Prouzet-Mauleon V, Bringaud F, Lehours P, Megraud F: Nucleotide sequence of the gyrA gene of Arcobacter species and characterization of human ciprofloxacin-resistant clinical isolates. FEMS Immunol Med Microbiol. 2007 Apr;49(3):337-45. Pubmed
  5. Taylor DE, Chau AS: Cloning and nucleotide sequence of the gyrA gene from Campylobacter fetus subsp. fetus ATCC 27374 and characterization of ciprofloxacin-resistant laboratory and clinical isolates. Antimicrob Agents Chemother. 1997 Mar;41(3):665-71. Pubmed

3. DNA topoisomerase 2-alpha

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
DNA topoisomerase 2-alpha P11388 Details

References:

  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. Pubmed
  2. Robinson MJ, Martin BA, Gootz TD, McGuirk PR, Osheroff N: Effects of novel fluoroquinolones on the catalytic activities of eukaryotic topoisomerase II: Influence of the C-8 fluorine group. Antimicrob Agents Chemother. 1992 Apr;36(4):751-6. Pubmed
  3. Hussy P, Maass G, Tummler B, Grosse F, Schomburg U: Effect of 4-quinolones and novobiocin on calf thymus DNA polymerase alpha primase complex, topoisomerases I and II, and growth of mammalian lymphoblasts. Antimicrob Agents Chemother. 1986 Jun;29(6):1073-8. Pubmed

Enzymes

1. Cytochrome P450 1A2

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Cytochrome P450 1A2 P05177 Details

References:

  1. Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). Accessed May 28, 2010.
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

2. Cytochrome P450 3A4

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Cytochrome P450 3A4 P08684 Details

References:

  1. Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). Accessed May 28, 2010.
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

3. Cytochrome P450 3A5

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Cytochrome P450 3A5 P20815 Details

References:

  1. Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). Accessed May 28, 2010.

4. Cytochrome P450 3A7

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Cytochrome P450 3A7 P24462 Details

References:

  1. Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). Accessed May 28, 2010.

Transporters

1. Multidrug resistance protein 1

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Multidrug resistance protein 1 P08183 Details

References:

  1. Wang E, Lew K, Barecki M, Casciano CN, Clement RP, Johnson WW: Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4. Chem Res Toxicol. 2001 Dec;14(12):1596-603. Pubmed
  2. Yamaguchi H, Yano I, Saito H, Inui K: Effect of cisplatin-induced acute renal failure on bioavailability and intestinal secretion of quinolone antibacterial drugs in rats. Pharm Res. 2004 Feb;21(2):330-8. Pubmed

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Drug created on June 13, 2005 07:24 / Updated on October 08, 2013 14:22