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Identification
NameCiprofloxacin
Accession NumberDB00537  (APRD00424, EXPT00999)
TypeSmall Molecule
GroupsApproved, Investigational
DescriptionA broad-spectrum antimicrobial carboxyfluoroquinoline. [PubChem]
Structure
Thumb
Synonyms
1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid
1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
1-Cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid
1-CYCLOPROPYL-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydroquinoline-3-carboxylic acid
1-Cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid
1-Cyclopropyl-6-fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid
1-Cyclopropyl-6-fluoro-7-hexahydro-1-pyrazinyl-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid
Ciprofloxacin
Ciprofloxacine
Ciprofloxacino
Ciprofloxacinum
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Act Ciprofloxacintablet500 mgoralActavis Pharma Company2004-02-18Not applicableCanada
Act Ciprofloxacintablet750 mgoralActavis Pharma Company2004-02-18Not applicableCanada
Act Ciprofloxacintablet250 mgoralActavis Pharma Company2004-02-18Not applicableCanada
Auro-ciprofloxacintablet500 mgoralAuro Pharma Inc2012-06-13Not applicableCanada
Auro-ciprofloxacintablet750 mgoralAuro Pharma Inc2012-06-13Not applicableCanada
Auro-ciprofloxacintablet250 mgoralAuro Pharma Inc2012-06-13Not applicableCanada
Bio-ciprofloxacintablet500 mgoralBiomed Pharma2016-06-17Not applicableCanada
Ciloxansolution0.3 %ophthalmicAlcon Canada Inc1992-12-31Not applicableCanada
Ciloxanointment3.33 mg/gophthalmicAlcon Laboratories, Inc.1998-06-02Not applicableUs
Ciloxanointment0.3 %ophthalmicAlcon Canada Inc1998-10-07Not applicableCanada
Ciloxansolution/ drops3 mg/mLophthalmicAlcon Laboratories, Inc.1991-01-15Not applicableUs
Ciloxansolution3.5 mg/mLophthalmicPhysicians Total Care, Inc.1995-07-10Not applicableUs
Ciprosolution, concentrate2 mg/mLintravenousBayer Health Care Pharmaceuticals Inc.2009-04-22Not applicableUs
CiprokitBayer Health Care Pharmaceuticals Inc.1997-09-26Not applicableUs
Ciprotablet, film coated500 mg/1oralBayer Health Care Pharmaceuticals Inc.1987-10-22Not applicableUs
CiprokitBayer Health Care Pharmaceuticals Inc.1997-09-26Not applicableUs
Ciprotablet, film coated250 mg/1oralBayer Health Care Pharmaceuticals Inc.1987-10-22Not applicableUs
Cipro 100 - Tab 100mgtablet100 mgoralBayer Inc1996-10-232001-01-16Canada
Cipro 250 - Tab 250mgtablet250 mgoralBayer Inc1996-10-10Not applicableCanada
Cipro 500 - Tab 500mgtablet500 mgoralBayer Inc1996-10-10Not applicableCanada
Cipro 750 - Tab 750mgtablet750 mgoralBayer Inc1996-10-11Not applicableCanada
Cipro I.V. - Liq 10mg/mlliquid10 mgintravenousBayer Inc1996-08-162005-07-27Canada
Cipro I.V. Minibags 2mg/mlsolution2 mgintravenousBayer Inc1998-12-022010-08-05Canada
Cipro IV 10mg/mlliquid10 mgintravenousMiles Canada Inc. Pharmaceutical Division1992-12-312000-08-01Canada
Cipro Oral Suspension 10%suspension10 goralBayer Inc1998-09-15Not applicableCanada
Cipro Tab 100mgtablet100 mgoralMiles Canada Inc. Pharmaceutical Division1994-12-312000-08-01Canada
Cipro Tab 250mgtablet250 mgoralMiles Canada Inc. Pharmaceutical Division1989-12-312000-08-01Canada
Cipro Tab 500mgtablet500 mgoralMiles Canada Inc. Pharmaceutical Division1989-12-312000-08-01Canada
Cipro Tab 750mgtablet750 mgoralMiles Canada Inc. Pharmaceutical Division1989-12-312000-08-01Canada
Cipro XLtablet (extended-release)500 mgoralBayer Inc2003-08-07Not applicableCanada
Cipro XLtablet (extended-release)1000 mgoralBayer Inc2004-04-08Not applicableCanada
Ciprofloxacintablet100 mgoralSivem Pharmaceuticals UlcNot applicableNot applicableCanada
Ciprofloxacintablet250 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Ciprofloxacintablet750 mgoralSivem Pharmaceuticals UlcNot applicableNot applicableCanada
Ciprofloxacintablet250 mgoralSanis Health Inc2010-07-26Not applicableCanada
Ciprofloxacintablet500 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Ciprofloxacintablet500 mgoralSanis Health Inc2010-07-26Not applicableCanada
Ciprofloxacintablet250 mgoralSivem Pharmaceuticals Ulc2012-06-12Not applicableCanada
Ciprofloxacintablet500 mgoralSivem Pharmaceuticals Ulc2012-06-12Not applicableCanada
Ciprofloxacintablet750 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Ciprofloxacintablet750 mgoralSanis Health Inc2010-07-26Not applicableCanada
Ciprofloxacin Hydrochloridesolution/ drops3 mg/mLophthalmicSandoz Inc.2004-05-07Not applicableUs
Ciprofloxacin Hydrochloridesolution3.5 mg/mLophthalmicSTAT Rx USA LLC2004-05-07Not applicableUs
Ciprofloxacin Hydrochloridesolution3.5 mg/mLophthalmicRebel Distributors Corp1990-12-31Not applicableUs
Ciprofloxacin Injectionsolution2 mgintravenousOmega Laboratories Ltd2012-04-17Not applicableCanada
Ciprofloxacin Injectionsolution10 mgintravenousFresenius Kabi Canada LtdNot applicableNot applicableCanada
Ciprofloxacin Injectionsolution2 mgintravenousFresenius Kabi Canada LtdNot applicableNot applicableCanada
Ciprofloxacin Injectionsolution0.2 %intravenousClaris Pharmaservices2008-05-16Not applicableCanada
Ciprofloxacin Injection USPsolution10 mgintravenousSandoz Canada Incorporated2007-03-12Not applicableCanada
Ciprofloxacin Injection USPsolution2 mgintravenousHospira Healthcare Corporation2008-04-08Not applicableCanada
Ciprofloxacin Injection, USPsolution2 mgintravenousBaxter Corporation2008-08-252010-06-03Canada
Ciprofloxacin Intravenous Infusionsolution2.0 mgintravenousTeva Canada Limited2008-05-22Not applicableCanada
Ciprofloxacin Intravenous Infusion BPsolution2 mgintravenousSandoz Canada Incorporated2008-03-27Not applicableCanada
Ciprofloxacin Intravenous Infusion, BPsolution2 mgintravenousApotex Inc2008-03-27Not applicableCanada
Ciprofloxacin Omegasolution2 mgintravenousOmega Laboratories LtdNot applicableNot applicableCanada
Ciprofloxacin Oticsolution/ drops.5 mg/.25mLauricular (otic)Xspire Pharma2012-08-27Not applicableUs
Ciprofloxacin Tabletstablet250 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Ciprofloxacin Tabletstablet500 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Ciprofloxacin Tabletstablet750 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Ciprofloxacin Tablets USP - 100 mgtablet100 mgoralDr Reddys Laboratories IncNot applicableNot applicableCanada
Ciprofloxacin Tablets USP - 250 mgtablet250 mgoralDr Reddys Laboratories IncNot applicableNot applicableCanada
Ciprofloxacin Tablets USP - 500 mgtablet500 mgoralDr Reddys Laboratories IncNot applicableNot applicableCanada
Ciprofloxacin Tablets USP - 750 mgtablet750 mgoralDr Reddys Laboratories IncNot applicableNot applicableCanada
Ciprofloxacin-250tablet250 mgoralPro Doc Limitee2004-04-072009-07-23Canada
Ciprofloxacin-500tablet500 mgoralPro Doc Limitee2004-04-072010-07-13Canada
Ciprofloxacin-750tablet750 mgoralPro Doc Limitee2004-04-072009-07-23Canada
Dom-ciprofloxacintablet100 mgoralDominion PharmacalNot applicableNot applicableCanada
Dom-ciprofloxacintablet250 mgoralDominion Pharmacal2004-03-26Not applicableCanada
Dom-ciprofloxacintablet500 mgoralDominion Pharmacal2004-03-26Not applicableCanada
Dom-ciprofloxacintablet750 mgoralDominion Pharmacal2004-03-26Not applicableCanada
Ipg-ciprofloxacintablet500 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-ciprofloxacintablet750 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-ciprofloxacintablet250 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Jamp-ciprofloxacintablet250 mgoralJamp Pharma Corporation2012-03-13Not applicableCanada
Jamp-ciprofloxacintablet500 mgoralJamp Pharma Corporation2012-03-13Not applicableCanada
Jamp-ciprofloxacintablet750 mgoralJamp Pharma Corporation2012-03-13Not applicableCanada
Mar-ciprofloxacintablet250 mgoralMarcan Pharmaceuticals Inc2012-09-06Not applicableCanada
Mar-ciprofloxacintablet500 mgoralMarcan Pharmaceuticals Inc2012-09-06Not applicableCanada
Mar-ciprofloxacintablet750 mgoralMarcan Pharmaceuticals Inc2012-09-06Not applicableCanada
Mint-ciprofloxtablet250 mgoralMint Pharmaceuticals Inc2014-06-02Not applicableCanada
Mint-ciprofloxtablet500 mgoralMint Pharmaceuticals Inc2014-06-02Not applicableCanada
Mint-ciprofloxtablet750 mgoralMint Pharmaceuticals Inc2014-06-02Not applicableCanada
Mint-ciprofloxacintablet250 mgoralMint Pharmaceuticals Inc2008-10-29Not applicableCanada
Mint-ciprofloxacintablet500 mgoralMint Pharmaceuticals Inc2008-10-29Not applicableCanada
Mint-ciprofloxacintablet750 mgoralMint Pharmaceuticals Inc2008-10-29Not applicableCanada
Mylan-ciprofloxacintablet250 mgoralMylan Pharmaceuticals Ulc2004-02-18Not applicableCanada
Mylan-ciprofloxacintablet500 mgoralMylan Pharmaceuticals Ulc2004-02-18Not applicableCanada
Mylan-ciprofloxacintablet750 mgoralMylan Pharmaceuticals Ulc2004-02-18Not applicableCanada
Mylan-ciprofloxacin XLtablet (extended-release)500 mgoralMylan Pharmaceuticals UlcNot applicableNot applicableCanada
Mylan-ciprofloxacin XLtablet (extended-release)1000 mgoralMylan Pharmaceuticals UlcNot applicableNot applicableCanada
Nu-ciprofloxsolution0.3 %ophthalmicNu Pharm IncNot applicableNot applicableCanada
Nu-ciprofloxacin Tabletstablet250 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-ciprofloxacin Tabletstablet500 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-ciprofloxacin Tabletstablet750 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-ciprofloxacin Tabletstablet100 mgoralNu Pharm IncNot applicableNot applicableCanada
Otipriosuspension6 mg/mLintratympanicOtonomy, Inc.2016-02-11Not applicableUs
PHL-ciprofloxacintablet250 mgoralPharmel Inc2004-04-06Not applicableCanada
PHL-ciprofloxacintablet100 mgoralPharmel IncNot applicableNot applicableCanada
PHL-ciprofloxacintablet500 mgoralPharmel Inc2004-04-06Not applicableCanada
PHL-ciprofloxacintablet750 mgoralPharmel Inc2004-04-06Not applicableCanada
PMS-ciprofloxacintablet500 mgoralPharmascience Inc2004-02-18Not applicableCanada
PMS-ciprofloxacintablet750 mgoralPharmascience Inc2004-02-18Not applicableCanada
PMS-ciprofloxacintablet100 mgoralPharmascience IncNot applicableNot applicableCanada
PMS-ciprofloxacintablet250 mgoralPharmascience Inc2004-02-18Not applicableCanada
PMS-ciprofloxacin 0.3%solution0.3 %ophthalmicPharmascience Inc2005-02-072013-05-31Canada
PMS-ciprofloxacin XLtablet (extended-release)500 mgoralPharmascience Inc2014-01-14Not applicableCanada
Priva-ciprofloxacintablet500 mgoralPharmapar Inc2016-06-17Not applicableCanada
Pro-ciprofloxacintablet500 mgoralPro Doc Limitee2008-10-27Not applicableCanada
Pro-ciprofloxacintablet250 mgoralPro Doc Limitee2008-10-27Not applicableCanada
Proquin XRtablet, film coated, extended release500 mg/1oralDepomed, Inc.2005-10-01Not applicableUs
Q-ciprofloxacintablet250 mgoralQd Pharmaceuticals UlcNot applicableNot applicableCanada
Q-ciprofloxacintablet500 mgoralQd Pharmaceuticals UlcNot applicableNot applicableCanada
Q-ciprofloxacintablet750 mgoralQd Pharmaceuticals UlcNot applicableNot applicableCanada
Ran-ciprofloxtablet500 mgoralRanbaxy Pharmaceuticals Canada Inc.2008-01-24Not applicableCanada
Ran-ciprofloxtablet750 mgoralRanbaxy Pharmaceuticals Canada Inc.2008-01-24Not applicableCanada
Ran-ciprofloxtablet250 mgoralRanbaxy Pharmaceuticals Canada Inc.2008-01-24Not applicableCanada
Ran-ciprofloxacintablet750 mgoralRanbaxy Pharmaceuticals Canada Inc.2005-07-052010-08-06Canada
Ran-ciprofloxacintablet250 mgoralRanbaxy Pharmaceuticals Canada Inc.2005-07-052010-08-06Canada
Ran-ciprofloxacintablet500 mgoralRanbaxy Pharmaceuticals Canada Inc.2005-07-052010-08-06Canada
Ratio-ciprofloxacintablet250 mgoralTeva Canada Limited2004-02-18Not applicableCanada
Ratio-ciprofloxacintablet500 mgoralTeva Canada Limited2004-02-18Not applicableCanada
Ratio-ciprofloxacintablet750 mgoralTeva Canada Limited2004-02-18Not applicableCanada
Riva-ciprofloxacintablet750 mgoralLaboratoire Riva Inc2004-03-25Not applicableCanada
Riva-ciprofloxacintablet250 mgoralLaboratoire Riva Inc2004-03-25Not applicableCanada
Riva-ciprofloxacintablet500 mgoralLaboratoire Riva Inc2004-03-25Not applicableCanada
Riva-ciprofloxacintablet100 mgoralLaboratoire Riva IncNot applicableNot applicableCanada
Sandoz Ciprofloxacintablet750 mgoralSandoz Canada Incorporated2004-02-18Not applicableCanada
Sandoz Ciprofloxacintablet250 mgoralSandoz Canada Incorporated2004-02-18Not applicableCanada
Sandoz Ciprofloxacintablet500 mgoralSandoz Canada Incorporated2004-02-18Not applicableCanada
Sandoz Ciprofloxacinsolution0.3 %ophthalmicSandoz Canada Incorporated2012-07-03Not applicableCanada
Septa-ciprofloxacintablet250 mgoralSepta Pharmaceuticals Inc2012-09-12Not applicableCanada
Septa-ciprofloxacintablet500 mgoralSepta Pharmaceuticals Inc2012-09-12Not applicableCanada
Septa-ciprofloxacintablet750 mgoralSepta Pharmaceuticals Inc2012-09-12Not applicableCanada
Taro-ciprofloxacintablet250 mgoralTaro Pharmaceuticals Inc2006-02-22Not applicableCanada
Taro-ciprofloxacintablet500 mgoralTaro Pharmaceuticals Inc2006-02-22Not applicableCanada
Taro-ciprofloxacintablet750 mgoralTaro Pharmaceuticals IncNot applicableNot applicableCanada
Teva-ciprofloxacintablet250 mgoralTeva Canada Limited2004-07-09Not applicableCanada
Teva-ciprofloxacintablet500 mgoralTeva Canada Limited2004-07-09Not applicableCanada
Teva-ciprofloxacintablet750 mgoralTeva Canada Limited2004-07-09Not applicableCanada
Van-ciprofloxacintablet250 mgoralVanc Pharmaceuticals Inc2015-05-21Not applicableCanada
Van-ciprofloxacintablet500 mgoralVanc Pharmaceuticals Inc2015-05-21Not applicableCanada
Van-ciprofloxacintablet750 mgoralVanc Pharmaceuticals Inc2015-05-21Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-ciprofloxsolution0.3 %ophthalmicApotex Inc2005-09-14Not applicableCanada
Apo-ciprofloxtablet250 mgoralApotex Inc2004-02-09Not applicableCanada
Apo-ciprofloxtablet500 mgoralApotex Inc2004-02-09Not applicableCanada
Apo-ciprofloxtablet750 mgoralApotex Inc2004-02-09Not applicableCanada
Ciprofloxacintablet500 mg/1oralLake Erie Medical DBA Quality Care Products LLC2004-09-10Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralPd Rx Pharmaceuticals, Inc.2009-10-10Not applicableUs
Ciprofloxacintablet250 mg/1oralREMEDYREPACK INC.2011-05-23Not applicableUs
Ciprofloxacinsolution/ drops3 mg/mLophthalmicREMEDYREPACK INC.2013-12-17Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralBlenheim Pharmacal, Inc.2011-02-15Not applicableUs
Ciprofloxacintablet, film coated250 mg/1oralA S Medication Solutions Llc2004-06-09Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralHHS/Program Support Center/Supply Service Center2011-12-22Not applicableUs
Ciprofloxacintablet, film coated750 mg/1oralWest Ward Pharmaceuticals Corp2004-06-09Not applicableUs
Ciprofloxacintablet250 mg/1oralSt Marys Medical Park Pharmacy2014-01-16Not applicableUs
Ciprofloxacintablet, film coated750 mg/1oralRanbaxy Pharmaceuticals Inc.2004-06-09Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralRed Pharm Drug Inc.2004-06-09Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralPreferred Pharmaceuticals, Inc.2014-10-21Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralNorth Star Rx Llc2007-04-26Not applicableUs
Ciprofloxacinsolution/ drops3 mg/mLophthalmic; topicalPACK Pharmaceuticals, LLC2010-09-15Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralBlu Pharmaceuticals, LLC2004-06-09Not applicableUs
Ciprofloxacinsolution/ drops3.5 mg/mLophthalmicPharma Force, Inc.2008-01-16Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralUnit Dose Services2004-06-09Not applicableUs
Ciprofloxacinsolution/ drops3 mg/mLophthalmicHenry Schein Inc.2015-05-13Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralAphena Pharma Solutions New Jersey, Llc2009-08-01Not applicableUs
Ciprofloxacintablet500 mg/1oralBlenheim Pharmacal, Inc.2010-05-17Not applicableUs
Ciprofloxacintablet, film coated750 mg/1oralDr. Reddy's Laboratories Limited2004-06-09Not applicableUs
Ciprofloxacininjection, solution, concentrate10 mg/mLintravenousPfizer Labs, Division of Pfizer Inc2009-09-11Not applicableUs
Ciprofloxacintablet, film coated750 mg/1oralHikma Pharmaceutical2004-06-09Not applicableUs
Ciprofloxacintablet500 mg/1oralProficient Rx LP2004-09-10Not applicableUs
Ciprofloxacintablet, film coated250 mg/1oralAurobindo Pharma Limited2007-04-26Not applicableUs
CiprofloxacinkitLupin Pharmaceuticals, Inc.2014-06-06Not applicableUs
Ciprofloxacinsolution/ drops3.5 mg/mLtopicalLake Erie Medical DBA Quality Care Products LLC2008-03-20Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralKAISER FOUNDATION HOSPITALS2010-02-26Not applicableUs
Ciprofloxacintablet250 mg/1oralDIRECT RX2014-01-01Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2012-11-20Not applicableUs
Ciprofloxacintablet, film coated250 mg/1oralAmerican Health Packaging2013-07-08Not applicableUs
Ciprofloxacintablet500 mg/1oralLife Line Home Care Services, Inc.2012-02-06Not applicableUs
Ciprofloxacintablet250 mg/1oralRebel Distributors Corp2003-08-19Not applicableUs
Ciprofloxacininjection, solution, concentrate10 mg/mLintravenousClaris Lifesciences Inc.2009-09-17Not applicableUs
Ciprofloxacinsolution/ drops3 mg/mLophthalmic; topicalMedsource Pharmaceuticals2005-01-21Not applicableUs
Ciprofloxacinsolution/ drops3 mg/mLophthalmic; topicalLake Erie Medical DBA Quality Care Products LLC2005-01-21Not applicableUs
Ciprofloxacintablet, film coated750 mg/1oralH.J. Harkins Company, Inc.2004-06-09Not applicableUs
Ciprofloxacintablet, film coated250 mg/1oralBlenheim Pharmacal, Inc.2010-05-17Not applicableUs
Ciprofloxacinsolution/ drops3 mg/mLophthalmic; topicalPhysicians Total Care, Inc.2004-08-09Not applicableUs
Ciprofloxacintablet, film coated250 mg/1oralActavis Pharma, Inc.2004-06-09Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralA S Medication Solutions Llc2004-06-09Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralHHS/Program Support Center/Supply Service Center2004-06-09Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralCardinal Health2012-06-29Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralWest ward Pharmaceutical Corp2004-06-09Not applicableUs
Ciprofloxacintablet, film coated250 mg/1oralApotex Corp2005-04-19Not applicableUs
Ciprofloxacinsolution/ drops3 mg/mLophthalmic; topicalProficient Rx LP2005-01-21Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralPreferred Pharmaceuticals, Inc.2004-06-09Not applicableUs
Ciprofloxacininjection, solution2 mg/mLintravenousCardinal Health2008-03-18Not applicableUs
Ciprofloxacintablet500 mg/1oralSTAT Rx USA LLC2004-09-10Not applicableUs
Ciprofloxacintablet250 mg/1oralAidarex Pharmaceuticals LLC2004-09-10Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralPd Rx Pharmaceuticals, Inc.2004-06-09Not applicableUs
Ciprofloxacintablet, film coated250 mg/1oralREMEDYREPACK INC.2013-05-02Not applicableUs
Ciprofloxacininjection2 mg/mLintravenousSandoz Inc2008-03-24Not applicableUs
Ciprofloxacintablet, film coated750 mg/1oralNorth Star Rx Llc2007-04-26Not applicableUs
Ciprofloxacintablet, film coated250 mg/1oralLake Erie Medical DBA Quality Care Products LLC2013-05-02Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralAphena Pharma Solutions Tennessee, Llc2009-08-01Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralGen Source Rx2007-04-262016-03-29Us
Ciprofloxacintablet500 mg/1oralBlenheim Pharmacal, Inc.2012-06-27Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralPhysicians Total Care, Inc.2003-09-12Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralApotheca Inc.2004-06-09Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralPd Rx Pharmaceuticals, Inc.2004-06-09Not applicableUs
Ciprofloxacintablet, film coated250 mg/1oralIVAX Pharmaceuticals, Inc.2004-06-09Not applicableUs
Ciprofloxacintablet250 mg/1oralREMEDYREPACK INC.2014-11-18Not applicableUs
Ciprofloxacintablet, film coated250 mg/1oralbryant ranch prepack2004-06-09Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralRed Pharm Drug Inc.2004-06-09Not applicableUs
Ciprofloxacinsolution/ drops3.5 mg/mLtopicalPreferred Pharmaceuticals, Inc.2014-07-03Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralLegacy Pharmaceutical Packaging2011-04-12Not applicableUs
Ciprofloxacintablet, film coated250 mg/1oralCarlsbad Technology, Inc.2009-10-10Not applicableUs
Ciprofloxacintablet250 mg/1oralRising Pharmaceuticals, Inc.2004-09-10Not applicableUs
Ciprofloxacininjection, solution2 mg/mLintravenousSagent Pharmaceuticals2008-03-24Not applicableUs
Ciprofloxacinsolution/ drops3 mg/mLophthalmic; topicalRebel Distributors Corp2005-01-21Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralMylan Institutional Inc.2011-04-11Not applicableUs
Ciprofloxacininjection, solution, concentrate200 mg/20mLintravenousHospira, Inc.2006-08-28Not applicableUs
Ciprofloxacintablet, film coated250 mg/1oralBlenheim Pharmacal, Inc.2015-04-30Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralCardinal Health2004-08-19Not applicableUs
Ciprofloxacininjection, solution, concentrate10 mg/mLintravenousPfizer Labs, Division of Pfizer Inc2009-09-11Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralHikma Pharmaceutical2004-06-09Not applicableUs
Ciprofloxacintablet250 mg/1oralProficient Rx LP2004-09-10Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralAurobindo Pharma Limited2007-04-26Not applicableUs
Ciprofloxacintablet, film coated250 mg/1oralH.J. Harkins Company, Inc.2004-06-09Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralBlenheim Pharmacal, Inc.2010-05-17Not applicableUs
Ciprofloxacintablet, film coated100 mg/1oralDr. Reddy's Laboratories Limited2004-06-09Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralActavis Pharma, Inc.2004-06-09Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralClinical Solutions Wholesale2004-06-09Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralKAISER FOUNDATION HOSPITALS2015-10-29Not applicableUs
Ciprofloxacinsolution/ drops3.5 mg/1topicalDIRECT RX2014-01-01Not applicableUs
Ciprofloxacintablet, film coated250 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2007-04-26Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralAmerican Health Packaging2013-07-08Not applicableUs
Ciprofloxacininjection10 mg/mLintravenousRebel Distributors Corp2006-08-28Not applicableUs
Ciprofloxacininjection, solution, concentrate10 mg/mLintravenousClaris Lifesciences Inc.2009-09-17Not applicableUs
Ciprofloxacinsolution/ drops3 mg/mLophthalmic; topicalHi Tech Pharmacal Co., Inc.2005-01-21Not applicableUs
Ciprofloxacinsolution/ drops3.5 mg/mLtopicalREMEDYREPACK INC.2013-05-31Not applicableUs
Ciprofloxacininjection2 mg/mLintravenousSandoz Inc2008-03-24Not applicableUs
Ciprofloxacintablet, film coated250 mg/1oralA S Medication Solutions Llc2004-06-09Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralHHS/Program Support Center/Supply Service Center2004-06-09Not applicableUs
Ciprofloxacintablet, film coated250 mg/1oralWest Ward Pharmaceuticals Corp2004-06-09Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralApotex Corp2005-04-19Not applicableUs
Ciprofloxacintablet, film coated250 mg/1oralRanbaxy Pharmaceuticals Inc.2004-06-09Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralPreferred Pharmaceuticals, Inc.2014-11-12Not applicableUs
Ciprofloxacintablet, film coated750 mg/1oralSTAT Rx USA LLC2004-06-09Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralLake Erie Medical DBA Quality Care Products LLC2004-06-09Not applicableUs
Ciprofloxacintablet250 mg/1oralPd Rx Pharmaceuticals, Inc.2004-09-10Not applicableUs
Ciprofloxacintablet, film coated250 mg/1oralRed Pharm Drug Inc.2004-06-09Not applicableUs
Ciprofloxacintablet, film coated250 mg/1oralPreferred Pharmaceuticals, Inc.2012-11-21Not applicableUs
Ciprofloxacinsolution/ drops3 mg/mLophthalmicAkorn Inc.2009-07-24Not applicableUs
Ciprofloxacininjection, solution2 mg/mLintravenousClaris Lifesciences Inc.2008-08-04Not applicableUs
Ciprofloxacintablet500 mg/1oralMedsource Pharmaceuticals2004-09-10Not applicableUs
Ciprofloxacintablet250 mg/1oralLake Erie Medical DBA Quality Care Products LLC2012-02-29Not applicableUs
Ciprofloxacinsolution/ drops3 mg/mLophthalmic; topicalH.J. Harkins Company, Inc.2005-01-21Not applicableUs
Ciprofloxacintablet, film coated250 mg/1oralBlenheim Pharmacal, Inc.2010-02-03Not applicableUs
Ciprofloxacintablet, film coated250 mg/1oralPhysicians Total Care, Inc.2003-08-19Not applicableUs
Ciprofloxacintablet, film coated250 mg/1oralAurolife Pharma LLC2009-08-01Not applicableUs
Ciprofloxacintablet, film coated250 mg/1oralPd Rx Pharmaceuticals, Inc.2004-06-09Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralIVAX Pharmaceuticals, Inc.2004-06-09Not applicableUs
Ciprofloxacintablet500 mg/1oralREMEDYREPACK INC.2015-04-16Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralbryant ranch prepack2004-06-09Not applicableUs
Ciprofloxacinsolution/ drops3.5 mg/mLtopicalProficient Rx LP2008-03-20Not applicableUs
Ciprofloxacintablet, film coated750 mg/1oralAurobindo Pharma Limited2007-04-26Not applicableUs
Ciprofloxacintablet, film coated250 mg/1oralPreferred Pharmaceuticals, Inc.2011-06-14Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralCarlsbad Technology, Inc.2009-10-10Not applicableUs
Ciprofloxacintablet500 mg/1oralRising Pharmaceuticals, Inc.2004-09-10Not applicableUs
Ciprofloxacintablet500 mg/1oralAidarex Pharmaceuticals LLC2004-09-10Not applicableUs
Ciprofloxacintablet, film coated250 mg/1oralAv Kare, Inc.2014-06-16Not applicableUs
Ciprofloxacintablet500 mg/1oralNorthwind Pharmaceuticals2014-06-01Not applicableUs
Ciprofloxacininjection, solution2 mg/mLintravenousHospira, Inc.2008-03-18Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralBlenheim Pharmacal, Inc.2014-10-24Not applicableUs
Ciprofloxacintablet, film coated250 mg/1oralCardinal Health2004-08-19Not applicableUs
Ciprofloxacininjection, solution2 mg/mLintravenousPfizer Labs, Division of Pfizer Inc2009-09-11Not applicableUs
Ciprofloxacintablet, film coated250 mg/1oralHikma Pharmaceutical2004-06-09Not applicableUs
Ciprofloxacintablet250 mg/1oralUnit Dose Services2004-09-10Not applicableUs
Ciprofloxacintablet, coated500 mg/1oralTestpak Holding Company2009-10-10Not applicableUs
Ciprofloxacintablet, film coated250 mg/1oralDr. Reddy's Laboratories Limited2004-06-09Not applicableUs
Ciprofloxacintablet, film coated750 mg/1oralActavis Pharma, Inc.2004-06-09Not applicableUs
Ciprofloxacintablet250 mg/1oralClinical Solutions Wholesale2004-09-10Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralBlenheim Pharmacal, Inc.2015-02-27Not applicableUs
Ciprofloxacintablet, film coated250 mg/1oralReady Meds2004-06-09Not applicableUs
Ciprofloxacintablet, film coated750 mg/1oralAmerican Health Packaging2013-07-08Not applicableUs
Ciprofloxacininjection, solution, concentrate400 mg/40mLintravenousRebel Distributors Corp2009-12-08Not applicableUs
Ciprofloxacininjection, solution2 mg/mLintravenousClaris Lifesciences Inc.2008-08-04Not applicableUs
Ciprofloxacinsolution/ drops3.5 mg/mLtopicalREMEDYREPACK INC.2013-04-23Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralMajor Pharmaceuticals2014-06-09Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralA S Medication Solutions Llc2004-06-09Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralHHS/Program Support Center/Supply Service Center2004-06-09Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralWest Ward Pharmaceuticals Corp2004-06-09Not applicableUs
Ciprofloxacintablet, film coated750 mg/1oralApotex Corp2008-03-13Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralRanbaxy Pharmaceuticals Inc.2004-06-09Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralRed Pharm Drug Inc.2009-08-01Not applicableUs
Ciprofloxacintablet250 mg/1oralPreferred Pharmaceuticals, Inc.2015-01-29Not applicableUs
Ciprofloxacintablet, film coated250 mg/1oralNorth Star Rx Llc2007-04-26Not applicableUs
Ciprofloxacintablet, film coated250 mg/1oralLake Erie Medical DBA Quality Care Products LLC2004-06-09Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralPd Rx Pharmaceuticals, Inc.2011-05-24Not applicableUs
Ciprofloxacintablet500 mg/1oralDIRECT RX2014-01-01Not applicableUs
Ciprofloxacintablet, film coated750 mg/1oralbryant ranch prepack2004-06-09Not applicableUs
Ciprofloxacintablet250 mg/1oralRed Pharm Drug Inc.2004-09-10Not applicableUs
Ciprofloxacinsolution/ drops3 mg/mLophthalmic; topicalPreferred Pharmaceuticals, Inc.2012-01-12Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralRebel Distributors Corp.2004-06-09Not applicableUs
Ciprofloxacininjection, solution2 mg/mLintravenousClaris Lifesciences Inc.2008-08-04Not applicableUs
Ciprofloxacinsolution/ drops3.5 mg/mLtopicalMedsource Pharmaceuticals2008-03-20Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-11-03Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralH.J. Harkins Company, Inc.2004-06-09Not applicableUs
Ciprofloxacintablet250 mg/1oralBlenheim Pharmacal, Inc.2010-05-17Not applicableUs
Ciprofloxacintablet, film coated750 mg/1oralPhysicians Total Care, Inc.2004-03-17Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralAurolife Pharma LLC2009-08-01Not applicableUs
Ciprofloxacintablet, film coated750 mg/1oralPd Rx Pharmaceuticals, Inc.2004-06-09Not applicableUs
Ciprofloxacintablet, film coated750 mg/1oralIVAX Pharmaceuticals, Inc.2004-06-09Not applicableUs
Ciprofloxacininjection, solution2 mg/mLintravenousPfizer Labs, Division of Pfizer Inc2009-09-11Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralGolden State Medical Supply, Inc2014-11-03Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralProficient Rx LP2004-06-09Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralMed Vantx, Inc.2007-04-26Not applicableUs
Ciprofloxacintablet500 mg/1oralPreferred Pharmaceuticals, Inc.2011-06-10Not applicableUs
Ciprofloxacintablet, film coated750 mg/1oralCarlsbad Technology, Inc.2009-10-10Not applicableUs
Ciprofloxacintablet750 mg/1oralRising Pharmaceuticals, Inc.2004-09-10Not applicableUs
Ciprofloxacintablet750 mg/1oralAidarex Pharmaceuticals LLC2004-09-10Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralREMEDYREPACK INC.2013-03-14Not applicableUs
Ciprofloxacininjection, solution, concentrate400 mg/40mLintravenousHospira, Inc.2006-08-28Not applicableUs
Ciprofloxacintablet500 mg/1oralState of Florida DOH Central Pharmacy2014-11-01Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralBlenheim Pharmacal, Inc.2004-06-09Not applicableUs
Ciprofloxacintablet, film coated250 mg/1oralCardinal Health2004-06-09Not applicableUs
Ciprofloxacinsolution/ drops3 mg/mLophthalmic; topicalUnit Dose Services2005-01-21Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralBlenheim Pharmacal, Inc.2010-05-17Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralDr. Reddy's Laboratories Limited2004-06-09Not applicableUs
Ciprofloxacinsolution/ drops3.5 mg/mLtopicalPACK Pharmaceuticals, LLC2008-03-20Not applicableUs
Ciprofloxacinsolution/ drops3 mg/mLophthalmic; topicalClinical Solutions Wholesale2005-01-21Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralMylan Pharmaceuticals Inc.2004-06-09Not applicableUs
Ciprofloxacinsolution/ drops3 mg/mLophthalmic; topicalProficient Rx LP2004-08-09Not applicableUs
Ciprofloxacintablet, film coated500 mg/1oralReady Meds2004-06-09Not applicableUs
CiprofloxacinkitLupin Pharmaceuticals, Inc.2014-06-06Not applicableUs
Ciprofloxacinsolution/ drops3 mg/mLophthalmicBausch & Lomb Incorporated2004-06-09Not applicableUs
Ciprofloxacininjection, solution2 mg/mLintravenousClaris Lifesciences Inc.2012-10-23Not applicableUs
Ciprofloxacin Hydrochloridetablet750 mg/1oralCardinal Health2009-10-09Not applicableUs
Ciprofloxacin Hydrochloridetablet, film coated500 mg/1oralREMEDYREPACK INC.2011-04-20Not applicableUs
Ciprofloxacin Hydrochloridetablet500 mg/1oralMed Vantx, Inc.2004-06-09Not applicableUs
Ciprofloxacin Hydrochloridetablet500 mg/1oralREMEDYREPACK INC.2011-08-04Not applicableUs
Ciprofloxacin Hydrochloridetablet500 mg/1oralREMEDYREPACK INC.2011-12-12Not applicableUs
Ciprofloxacin Hydrochloridetablet250 mg/1oralREMEDYREPACK INC.2011-05-05Not applicableUs
Ciprofloxacin Hydrochloridetablet500 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Ciprofloxacin Hydrochloridetablet250 mg/1oralREMEDYREPACK INC.2010-10-11Not applicableUs
Ciprofloxacin Hydrochloridetablet, film coated500 mg/1oralREMEDYREPACK INC.2011-03-15Not applicableUs
Ciprofloxacin Hydrochloridetablet500 mg/1oralCardinal Health2009-10-09Not applicableUs
Ciprofloxacin Hydrochloridetablet500 mg/1oralRed Pharm Drug Inc.2011-04-04Not applicableUs
Ciprofloxacin Hydrochloridetablet500 mg/1oralREMEDYREPACK INC.2011-06-08Not applicableUs
Ciprofloxacin Hydrochloridetablet500 mg/1oralBlenheim Pharmacal, Inc.2010-05-17Not applicableUs
Ciprofloxacin Hydrochloridetablet500 mg/1oralKAISER FOUNDATION HOSPITALS2011-06-23Not applicableUs
Ciprofloxacin Hydrochloridetablet500 mg/1oralREMEDYREPACK INC.2010-10-18Not applicableUs
Ciprofloxacin Hydrochloridetablet500 mg/1oralREMEDYREPACK INC.2011-12-07Not applicableUs
Ciprofloxacin Hydrochloridetablet250 mg/1oralCardinal Health2009-10-09Not applicableUs
Ciprofloxacin Hydrochloridetablet500 mg/1oralApothecary Shop Wholesale Inc.2011-07-01Not applicableUs
Ciprofloxacin Hydrochloridetablet250 mg/1oralREMEDYREPACK INC.2011-07-29Not applicableUs
Ciprofloxacin Hydrochloridetablet, coated500 mg/1oralTestpak Holding Company2009-12-03Not applicableUs
Ciprofloxacin Hydrochloridetablet500 mg/1oralREMEDYREPACK INC.2010-11-22Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
BacquinorNot Available
BaycipNot Available
CifloxNot Available
CifloxinNot Available
CiprinolNot Available
CiprobayNot Available
CiprocinolNot Available
CiprodarNot Available
CiproxanNot Available
CiproxinNot Available
FlociprinNot Available
ProquinNot Available
Brand mixtures
NameLabellerIngredients
CiproBayer Health Care Pharmaceuticals Inc.
Cipro HCAlcon Laboratories, Inc.
Cipro HC Otic SuspensionAlcon Canada Inc
CiprodexRebel Distributors Corp
CiprofloxacinMylan Pharmaceuticals Inc.
Ciprofloxacin Extended-releasePar Pharmaceutical, Inc.
Salts
Name/CASStructureProperties
Ciprofloxacin Hydrochloride
93107-08-5
Thumb
  • InChI Key: DIOIOSKKIYDRIQ-UHFFFAOYSA-N
  • Monoisotopic Mass: 367.109897401
  • Average Mass: 367.802
DBSALT000293
Categories
UNII5E8K9I0O4U
CAS number85721-33-1
WeightAverage: 331.3415
Monoisotopic: 331.133219662
Chemical FormulaC17H18FN3O3
InChI KeyInChIKey=MYSWGUAQZAJSOK-UHFFFAOYSA-N
InChI
InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24)
IUPAC Name
1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
SMILES
OC(=O)C1=CN(C2CC2)C2=CC(N3CCNCC3)=C(F)C=C2C1=O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as quinoline carboxylic acids. These are quinolines in which the quinoline ring system is substituted by a carboxyl group at one or more positions.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassQuinolines and derivatives
Sub ClassQuinoline carboxylic acids
Direct ParentQuinoline carboxylic acids
Alternative Parents
Substituents
  • Quinoline-3-carboxylic acid
  • N-arylpiperazine
  • Fluoroquinolone
  • Dihydroquinolone
  • Aminoquinoline
  • Dihydroquinoline
  • Pyridine carboxylic acid or derivatives
  • Pyridine carboxylic acid
  • Dialkylarylamine
  • Fluorobenzene
  • Benzenoid
  • Pyridine
  • Piperazine
  • 1,4-diazinane
  • Aryl halide
  • Aryl fluoride
  • Heteroaromatic compound
  • Vinylogous amide
  • Tertiary amine
  • Azacycle
  • Secondary amine
  • Monocarboxylic acid or derivatives
  • Secondary aliphatic amine
  • Carboxylic acid
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Organofluoride
  • Organohalogen compound
  • Carbonyl group
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of the following infections caused by susceptible organisms: urinary tract infections, acute uncomplicated cystitis, chronic bacterial prostatitis, lower respiratory tract infections, acute sinusitis, skin and skin structure infections, bone and joint infections, complicated intra-abdominal infections (used in combination with metronidazole), infectious diarrhea, typhoid fever (enteric fever), uncomplicated cervical and urethral gonorrhea, and inhalational anthrax (post-exposure).
PharmacodynamicsCiprofloxacin is a broad-spectrum antiinfective agent of the fluoroquinolone class. Ciprofloxacin has in vitro activity against a wide range of gram-negative and gram-positive microorganisms. The mechanism of action of quinolones, including ciprofloxacin, is different from that of other antimicrobial agents such as beta-lactams, macrolides, tetracyclines, or aminoglycosides; therefore, organisms resistant to these drugs may be susceptible to ciprofloxacin. There is no known cross-resistance between ciprofloxacin and other classes of antimicrobials. Notably the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian.
Mechanism of actionThe bactericidal action of ciprofloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, strand supercoiling repair, and recombination.
Related Articles
AbsorptionRapidly and well absorbed from the gastrointestinal tract after oral administration. The absolute bioavailability is approximately 70% with no substantial loss by first pass metabolism.
Volume of distributionNot Available
Protein binding20 to 40%
Metabolism

Hepatic. Four metabolites have been identified in human urine which together account for approximately 15% of an oral dose. The metabolites have antimicrobial activity, but are less active than unchanged ciprofloxacin.

Route of eliminationApproximately 40 to 50% of an orally administered dose is excreted in the urine as unchanged drug.
Half life4 hours
Clearance
  • Renal cl=300 mL/min
ToxicityThe major adverse effect seen with use of is gastrointestinal irritation, common with many antibiotics.
Affected organisms
  • Enteric bacteria and other eubacteria
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal AbsorptionNot AvailableNot Available
Blood Brain BarrierNot AvailableNot Available
Caco-2 permeableNot AvailableNot Available
P-glycoprotein substrateNot AvailableNot Available
P-glycoprotein inhibitor INot AvailableNot Available
P-glycoprotein inhibitor IINot AvailableNot Available
Renal organic cation transporterNot AvailableNot Available
CYP450 2C9 substrateNot AvailableNot Available
CYP450 2D6 substrateNot AvailableNot Available
CYP450 3A4 substrateNot AvailableNot Available
CYP450 1A2 substrateNot AvailableNot Available
CYP450 2C9 inhibitorNot AvailableNot Available
CYP450 2D6 inhibitorNot AvailableNot Available
CYP450 2C19 inhibitorNot AvailableNot Available
CYP450 3A4 inhibitorNot AvailableNot Available
CYP450 inhibitory promiscuityNot AvailableNot Available
Ames testNot AvailableNot Available
CarcinogenicityNot AvailableNot Available
BiodegradationNot AvailableNot Available
Rat acute toxicityNot AvailableNot applicable
hERG inhibition (predictor I)Not AvailableNot Available
hERG inhibition (predictor II)Not AvailableNot Available
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Bayer healthcare pharmaceuticals inc
  • Bayer pharmaceuticals corp
  • App pharmaceuticals llc
  • Bedford laboratories
  • Claris lifesciences ltd
  • Hospira inc
  • Teva parenteral medicines inc
  • West ward pharmaceutical corp
  • Hikma farmaceutica (portugal) sa
  • Acs dobfar info sa
  • Baxter healthcare corp
  • Bedford laboratories div ben venue laboratories inc
  • Alcon inc
  • Akorn inc
  • Bausch and lomb pharmaceuticals inc
  • Fdc ltd
  • Hitech pharmacal corp
  • Nexus pharmaceuticals inc
  • Novex pharma
  • Pharmaforce inc
  • Wraser pharmaceuticals llc
  • Depomed inc
  • Apotex inc
  • Aurobindo pharma ltd
  • Barr laboratories inc
  • Carlsbad technology inc
  • Dr reddys laboratories ltd
  • Hikma pharmaceuticals
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Mylan pharmaceuticals inc
  • Nostrum laboratories inc
  • Pliva inc
  • Ranbaxy pharmaceuticals inc
  • Sandoz inc
  • Taro pharmaceuticals usa inc
  • Teva pharmaceuticals usa inc
  • Unique pharmaceutical laboratories
  • Watson laboratories inc
  • Allergan inc
Packagers
Dosage forms
FormRouteStrength
Solutionophthalmic0.3 %
Ointmentophthalmic0.3 %
Ointmentophthalmic3.33 mg/g
Kit
Solution, concentrateintravenous2 mg/mL
Tabletoral250 mg
Tabletoral500 mg
Tabletoral750 mg
Suspensionauricular (otic)
Liquidintravenous10 mg
Suspensionoral10 g
Tabletoral100 mg
Tablet (extended-release)oral1000 mg
Tablet (extended-release)oral500 mg
Suspensionotic
Suspension/ dropsauricular (otic)
Injectionintravenous10 mg/mL
Injectionintravenous2 mg/mL
Injection, solutionintravenous2 mg/mL
Injection, solution, concentrateintravenous10 mg/mL
Injection, solution, concentrateintravenous200 mg/20mL
Injection, solution, concentrateintravenous400 mg/40mL
Solution/ dropsophthalmic3 mg/mL
Solution/ dropsophthalmic3.5 mg/mL
Solution/ dropsophthalmic; topical3 mg/mL
Solution/ dropstopical3.5 mg/1
Solution/ dropstopical3.5 mg/mL
Tabletoral250 mg/1
Tabletoral750 mg/1
Tablet, coatedoral500 mg/1
Tablet, film coatedoral100 mg/1
Tablet, film coatedoral250 mg/1
Tablet, film coatedoral500 mg/1
Tablet, film coatedoral750 mg/1
Tablet, film coated, extended releaseoral
Solutionophthalmic3.5 mg/mL
Tabletoral500 mg/1
Solutionintravenous0.2 %
Solutionintravenous10 mg
Solutionintravenous2 mg
Solutionintravenous2.0 mg
Solution/ dropsauricular (otic).5 mg/.25mL
Suspensionintratympanic6 mg/mL
Tablet, film coated, extended releaseoral500 mg/1
Prices
Unit descriptionCostUnit
Cipro 400 mg Solution 40ml Vial259.99USD vial
Floxin Otic 0.3% Solution 10ml Bottle142.91USD bottle
Cipro 500 mg/5ml(10%) Suspension 100ml Bottle136.75USD bottle
Cipro HC 0.2-1% Suspension 10ml Bottle131.54USD bottle
Cipro 250 mg/5ml(5%) Suspension 100ml Bottle116.8USD bottle
Ocuflox 0.3% Solution 10ml Bottle106.09USD bottle
Ciprofloxacin HCl 0.3% Solution 10ml Bottle98.22USD bottle
Ciloxan 0.3% Ointment 3.5 gm Tube87.49USD tube
Floxin Otic 0.3% Solution 5ml Bottle86.49USD bottle
Ciloxan 0.3% Solution 5ml Bottle68.33USD bottle
Ocuflox 0.3% Solution 5ml Bottle57.32USD bottle
Ciprofloxacin HCl 0.3% Solution 5ml Bottle49.2USD bottle
ProQuin XR 3 500 mg 24 Hour tablet Disp Pack39.99USD disp
Ciprofloxacin HCl 0.3% Solution 2.5ml Bottle26.03USD bottle
Ciloxan 0.3% eye drops13.33USD ml
Ciprofloxacin 0.3% eye drop12.96USD ml
Cipro hc otic suspension12.65USD ml
Proquin xr 500 mg tablet12.18USD tablet
Cipro xr 1000 mg tablet11.91USD tablet
Ciprofloxacin-Ciproflox HCl 1000 mg 24 Hour tablet11.6USD tablet
Ocuflox 0.3% eye drops11.35USD ml
ProQuin XR 500 mg 24 Hour tablet11.18USD tablet
Ciprofloxacin er 1000 mg tablet11.16USD tablet
Cipro XR 500 mg 24 Hour tablet10.88USD tablet
Cipro XR 1000 mg 24 Hour tablet10.75USD tablet
Cipro xr 500 mg tablet10.46USD tablet
Ciprofloxacin-Ciproflox HCl 500 mg 24 Hour tablet10.19USD tablet
Ciprofloxacin er 500 mg tablet9.8USD tablet
Floxin 400 mg tablet9.55USD tablet
Cetraxal 0.2% ear solution7.14USD each
Floxin 200 mg tablet6.6USD tablet
Cipro 750 mg tablet6.26USD tablet
Cipro 500 mg tablet6.08USD tablet
Ciprofloxacin hcl 750 mg tablet5.65USD tablet
Floxin 300 mg tablet5.61USD tablet
Ciprofloxacin hcl 500 mg tablet5.59USD tablet
Cipro 250 mg tablet5.2USD tablet
Ciprofloxacin hcl 250 mg tablet4.59USD tablet
Floxin otic singles4.28USD each
Ciprofloxacin hcl 100 mg tablet4.17USD tablet
Ciloxan 0.3 % Solution2.18USD ml
Ciprofloxacin hcl powder1.29USD g
Apo-Ciproflox 0.3 % Solution1.18USD ml
Pms-Ciprofloxacin 0.3 % Solution1.18USD ml
Cipro i.v. 10 mg/ml vial0.72USD ml
Cipro i.v. 200 mg/100 ml d5w0.16USD ml
Ciprofloxacin 200 mg/20 ml vial0.13USD ml
Ciprofloxacn-d5w 200 mg/100 ml0.03USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA1330946 No1994-07-262011-07-26Canada
CA2414271 No2005-09-272021-06-13Canada
US5286754 No1994-02-152011-02-15Us
US5972389 No1996-09-192016-09-19Us
US6284804 No2000-08-102020-08-10Us
US6340475 No1996-09-192016-09-19Us
US6359016 No2000-08-102020-08-10Us
US6488962 No2000-06-202020-06-20Us
US6635280 No1996-09-192016-09-19Us
US7709022 Yes2001-12-232021-12-23Us
US8187632 Yes2001-12-232021-12-23Us
US8318817 No2010-04-272030-04-27Us
US8846650 No2005-06-042025-06-04Us
US8932610 No2010-03-242030-03-24Us
US9149486 No2002-09-132022-09-13Us
US9205048 No2009-04-212029-04-21Us
US9220796 No2015-07-012035-07-01Us
US9233068 No2009-12-112029-12-11Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point255-257 °CNot Available
water solubility3E+004 mg/L (at 20 °C)NOWARA,A ET AL. (1997)
logP0.28TAKACS-NOVAK,K ET AL. (1992)
pKa6.09TORNIANEN,K ET AL. (1996)
Predicted Properties
PropertyValueSource
Water Solubility1.35 mg/mLALOGPS
logP-0.57ALOGPS
logP-0.81ChemAxon
logS-2.4ALOGPS
pKa (Strongest Acidic)5.76ChemAxon
pKa (Strongest Basic)8.68ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area72.88 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity87.94 m3·mol-1ChemAxon
Polarizability33.12 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis Reference

DrugSyn.org

US4670444
General References
  1. Drusano GL, Standiford HC, Plaisance K, Forrest A, Leslie J, Caldwell J: Absolute oral bioavailability of ciprofloxacin. Antimicrob Agents Chemother. 1986 Sep;30(3):444-6. [PubMed:3777908 ]
  2. Hilliard JJ, Krause HM, Bernstein JI, Fernandez JA, Nguyen V, Ohemeng KA, Barrett JF: A comparison of active site binding of 4-quinolones and novel flavone gyrase inhibitors to DNA gyrase. Adv Exp Med Biol. 1995;390:59-69. [PubMed:8718602 ]
  3. Spivey JM, Cummings DM, Pierson NR: Failure of prostatitis treatment secondary to probable ciprofloxacin-sucralfate drug interaction. Pharmacotherapy. 1996 Mar-Apr;16(2):314-6. [PubMed:8820479 ]
  4. Brouwers JR: Drug interactions with quinolone antibacterials. Drug Saf. 1992 Jul-Aug;7(4):268-81. [PubMed:1524699 ]
External Links
ATC CodesJ01MA02J01RA11S02AA15J01RA12S03AA07S01AE03J01RA10
AHFS Codes
  • 08:12.18
  • 52:04.04
PDB EntriesNot Available
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Interactions
Drug Interactions
Drug
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Ciprofloxacin.
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Ciprofloxacin.
AcetyldigitoxinAcetyldigitoxin may decrease the cardiotoxic activities of Ciprofloxacin.
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Ciprofloxacin.
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Ciprofloxacin.
AlbendazoleThe serum concentration of Ciprofloxacin can be increased when it is combined with Albendazole.
AldosteroneThe serum concentration of Ciprofloxacin can be decreased when it is combined with Aldosterone.
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Ciprofloxacin.
AlectinibThe serum concentration of Ciprofloxacin can be increased when it is combined with Alectinib.
AlfentanilThe serum concentration of Ciprofloxacin can be increased when it is combined with Alfentanil.
AlfuzosinAlfuzosin may increase the QTc-prolonging activities of Ciprofloxacin.
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Ciprofloxacin.
AmantadineAmantadine may increase the QTc-prolonging activities of Ciprofloxacin.
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Ciprofloxacin.
Aminohippuric acidThe serum concentration of Ciprofloxacin can be increased when it is combined with Aminohippuric acid.
AmiodaroneCiprofloxacin may increase the QTc-prolonging activities of Amiodarone.
AmiodaroneThe serum concentration of Ciprofloxacin can be decreased when it is combined with Amiodarone.
AmitriptylineAmitriptyline may increase the QTc-prolonging activities of Ciprofloxacin.
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Ciprofloxacin.
AmlodipineThe serum concentration of Ciprofloxacin can be increased when it is combined with Amlodipine.
AmoxapineAmoxapine may increase the QTc-prolonging activities of Ciprofloxacin.
AmprenavirThe serum concentration of Ciprofloxacin can be decreased when it is combined with Amprenavir.
AmsacrineThe serum concentration of Ciprofloxacin can be increased when it is combined with Amsacrine.
AnagrelideCiprofloxacin may increase the QTc-prolonging activities of Anagrelide.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Ciprofloxacin.
ApomorphineApomorphine may increase the QTc-prolonging activities of Ciprofloxacin.
ArformoterolArformoterol may increase the QTc-prolonging activities of Ciprofloxacin.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Ciprofloxacin.
AripiprazoleAripiprazole may increase the QTc-prolonging activities of Ciprofloxacin.
Arsenic trioxideCiprofloxacin may increase the QTc-prolonging activities of Arsenic trioxide.
ArtemetherCiprofloxacin may increase the QTc-prolonging activities of Artemether.
AsenapineCiprofloxacin may increase the QTc-prolonging activities of Asenapine.
AstemizoleThe serum concentration of Ciprofloxacin can be increased when it is combined with Astemizole.
AtazanavirAtazanavir may increase the QTc-prolonging activities of Ciprofloxacin.
AtazanavirThe serum concentration of Atazanavir can be increased when it is combined with Ciprofloxacin.
AtenololThe serum concentration of Atenolol can be increased when it is combined with Ciprofloxacin.
AtomoxetineAtomoxetine may increase the QTc-prolonging activities of Ciprofloxacin.
AtorvastatinThe serum concentration of Ciprofloxacin can be increased when it is combined with Atorvastatin.
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Ciprofloxacin.
AzelastineThe serum concentration of Ciprofloxacin can be increased when it is combined with Azelastine.
Azilsartan medoxomilAzilsartan medoxomil may increase the arrhythmogenic activities of Ciprofloxacin.
AzithromycinCiprofloxacin may increase the QTc-prolonging activities of Azithromycin.
AzithromycinThe serum concentration of Ciprofloxacin can be increased when it is combined with Azithromycin.
BedaquilineCiprofloxacin may increase the QTc-prolonging activities of Bedaquiline.
BenazeprilBenazepril may increase the arrhythmogenic activities of Ciprofloxacin.
BenzocaineThe serum concentration of Ciprofloxacin can be increased when it is combined with Benzocaine.
BepridilThe serum concentration of Ciprofloxacin can be increased when it is combined with Bepridil.
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Ciprofloxacin.
BevacizumabBevacizumab may increase the cardiotoxic activities of Ciprofloxacin.
BiperidenThe serum concentration of Ciprofloxacin can be increased when it is combined with Biperiden.
BoceprevirThe serum concentration of Boceprevir can be increased when it is combined with Ciprofloxacin.
BortezomibBortezomib may increase the QTc-prolonging activities of Ciprofloxacin.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Ciprofloxacin.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Ciprofloxacin.
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Ciprofloxacin.
BuprenorphineThe serum concentration of Ciprofloxacin can be increased when it is combined with Buprenorphine.
BuserelinBuserelin may increase the QTc-prolonging activities of Ciprofloxacin.
BuspironeThe serum concentration of Ciprofloxacin can be increased when it is combined with Buspirone.
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Ciprofloxacin.
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Ciprofloxacin.
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Ciprofloxacin.
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Ciprofloxacin.
CandesartanCandesartan may increase the arrhythmogenic activities of Ciprofloxacin.
CandoxatrilCandoxatril may increase the arrhythmogenic activities of Ciprofloxacin.
CaptoprilCaptopril may increase the arrhythmogenic activities of Ciprofloxacin.
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Ciprofloxacin.
CarbamazepineThe serum concentration of Ciprofloxacin can be decreased when it is combined with Carbamazepine.
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Ciprofloxacin.
CarvedilolThe serum concentration of Ciprofloxacin can be increased when it is combined with Carvedilol.
CaspofunginThe serum concentration of Ciprofloxacin can be increased when it is combined with Caspofungin.
CeritinibCeritinib may increase the QTc-prolonging activities of Ciprofloxacin.
CeritinibThe serum concentration of Ceritinib can be increased when it is combined with Ciprofloxacin.
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Ciprofloxacin.
ChloroquineCiprofloxacin may increase the QTc-prolonging activities of Chloroquine.
ChloroquineThe serum concentration of Ciprofloxacin can be increased when it is combined with Chloroquine.
ChlorpromazineThe serum concentration of Ciprofloxacin can be increased when it is combined with Chlorpromazine.
ChlorpropamideThe serum concentration of Ciprofloxacin can be increased when it is combined with Chlorpropamide.
ChlorprothixeneThe serum concentration of Ciprofloxacin can be increased when it is combined with Chlorprothixene.
CholesterolThe serum concentration of Ciprofloxacin can be increased when it is combined with Cholesterol.
Cholic AcidThe serum concentration of Ciprofloxacin can be decreased when it is combined with Cholic Acid.
CilazaprilCilazapril may increase the arrhythmogenic activities of Ciprofloxacin.
CimetidineThe serum concentration of Ciprofloxacin can be decreased when it is combined with Cimetidine.
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Ciprofloxacin.
CisaprideCiprofloxacin may increase the QTc-prolonging activities of Cisapride.
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Ciprofloxacin.
CitalopramCiprofloxacin may increase the QTc-prolonging activities of Citalopram.
CitalopramThe serum concentration of Ciprofloxacin can be increased when it is combined with Citalopram.
ClarithromycinThe serum concentration of Ciprofloxacin can be increased when it is combined with Clarithromycin.
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Ciprofloxacin.
ClofazimineThe serum concentration of Ciprofloxacin can be increased when it is combined with Clofazimine.
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Ciprofloxacin.
ClomipramineClomipramine may increase the QTc-prolonging activities of Ciprofloxacin.
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Ciprofloxacin.
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Ciprofloxacin.
ClotrimazoleThe serum concentration of Ciprofloxacin can be decreased when it is combined with Clotrimazole.
ClozapineCiprofloxacin may increase the QTc-prolonging activities of Clozapine.
CobicistatThe serum concentration of Ciprofloxacin can be increased when it is combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Ciprofloxacin.
ColchicineThe serum concentration of Ciprofloxacin can be increased when it is combined with Colchicine.
ColforsinThe serum concentration of Ciprofloxacin can be increased when it is combined with Colforsin.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Ciprofloxacin.
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Ciprofloxacin.
CyclophosphamideCyclophosphamide may increase the cardiotoxic activities of Ciprofloxacin.
CyclosporineThe serum concentration of Ciprofloxacin can be decreased when it is combined with Cyclosporine.
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Ciprofloxacin.
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be increased when it is combined with Ciprofloxacin.
DabrafenibDabrafenib may increase the QTc-prolonging activities of Ciprofloxacin.
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Ciprofloxacin.
DaclatasvirThe serum concentration of Ciprofloxacin can be increased when it is combined with Daclatasvir.
DactinomycinThe serum concentration of Ciprofloxacin can be increased when it is combined with Dactinomycin.
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Ciprofloxacin.
DasatinibDasatinib may increase the QTc-prolonging activities of Ciprofloxacin.
DasatinibThe serum concentration of Dasatinib can be increased when it is combined with Ciprofloxacin.
DaunorubicinThe serum concentration of Ciprofloxacin can be decreased when it is combined with Daunorubicin.
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Ciprofloxacin.
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Ciprofloxacin.
DegarelixDegarelix may increase the QTc-prolonging activities of Ciprofloxacin.
DesfluraneDesflurane may increase the QTc-prolonging activities of Ciprofloxacin.
DesipramineDesipramine may increase the QTc-prolonging activities of Ciprofloxacin.
DeslanosideDeslanoside may decrease the cardiotoxic activities of Ciprofloxacin.
DesloratadineThe serum concentration of Ciprofloxacin can be increased when it is combined with Desloratadine.
DexamethasoneThe serum concentration of Ciprofloxacin can be decreased when it is combined with Dexamethasone.
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Ciprofloxacin.
DextromethorphanThe serum concentration of Ciprofloxacin can be increased when it is combined with Dextromethorphan.
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Ciprofloxacin.
DiclofenacThe serum concentration of Ciprofloxacin can be increased when it is combined with Diclofenac.
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Ciprofloxacin.
DigitoxinDigitoxin may decrease the cardiotoxic activities of Ciprofloxacin.
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Ciprofloxacin.
DigoxinDigoxin may decrease the cardiotoxic activities of Ciprofloxacin.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Ciprofloxacin.
DihydroergotamineThe serum concentration of Ciprofloxacin can be increased when it is combined with Dihydroergotamine.
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Ciprofloxacin.
DiltiazemThe serum concentration of Ciprofloxacin can be increased when it is combined with Diltiazem.
DiphenhydramineDiphenhydramine may increase the QTc-prolonging activities of Ciprofloxacin.
DipyridamoleThe serum concentration of Ciprofloxacin can be increased when it is combined with Dipyridamole.
DisopyramideCiprofloxacin may increase the QTc-prolonging activities of Disopyramide.
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Ciprofloxacin.
DocetaxelThe risk or severity of adverse effects can be increased when Docetaxel is combined with Ciprofloxacin.
DofetilideCiprofloxacin may increase the QTc-prolonging activities of Dofetilide.
DolasetronCiprofloxacin may increase the QTc-prolonging activities of Dolasetron.
DomperidoneCiprofloxacin may increase the QTc-prolonging activities of Domperidone.
DoxazosinThe serum concentration of Ciprofloxacin can be increased when it is combined with Doxazosin.
DoxepinDoxepin may increase the QTc-prolonging activities of Ciprofloxacin.
DoxorubicinThe serum concentration of Ciprofloxacin can be decreased when it is combined with Doxorubicin.
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Ciprofloxacin.
DronabinolThe serum concentration of Ciprofloxacin can be increased when it is combined with Dronabinol.
DronedaroneCiprofloxacin may increase the QTc-prolonging activities of Dronedarone.
DronedaroneThe serum concentration of Ciprofloxacin can be increased when it is combined with Dronedarone.
DroperidolDroperidol may increase the QTc-prolonging activities of Ciprofloxacin.
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Ciprofloxacin.
ElbasvirThe serum concentration of Ciprofloxacin can be increased when it is combined with Elbasvir.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Ciprofloxacin.
EliglustatCiprofloxacin may increase the QTc-prolonging activities of Eliglustat.
EnalaprilEnalapril may increase the arrhythmogenic activities of Ciprofloxacin.
EnalaprilatEnalaprilat may increase the arrhythmogenic activities of Ciprofloxacin.
EnzalutamideThe serum concentration of Ciprofloxacin can be increased when it is combined with Enzalutamide.
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Ciprofloxacin.
EprosartanEprosartan may increase the arrhythmogenic activities of Ciprofloxacin.
ErgonovineThe serum concentration of Ciprofloxacin can be increased when it is combined with Ergonovine.
ErgotamineThe serum concentration of Ciprofloxacin can be increased when it is combined with Ergotamine.
EribulinEribulin may increase the QTc-prolonging activities of Ciprofloxacin.
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Ciprofloxacin.
ErythromycinThe serum concentration of Ciprofloxacin can be decreased when it is combined with Erythromycin.
ErythromycinThe serum concentration of Erythromycin can be increased when it is combined with Ciprofloxacin.
EscitalopramCiprofloxacin may increase the QTc-prolonging activities of Escitalopram.
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Ciprofloxacin.
EstramustineThe serum concentration of Ciprofloxacin can be increased when it is combined with Estramustine.
EstriolThe serum concentration of Ciprofloxacin can be decreased when it is combined with Estriol.
EstriolThe serum concentration of Estriol can be increased when it is combined with Ciprofloxacin.
EstroneThe serum concentration of Ciprofloxacin can be decreased when it is combined with Estrone.
EstroneThe serum concentration of Estrone can be increased when it is combined with Ciprofloxacin.
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Ciprofloxacin.
EtoposideThe serum concentration of Ciprofloxacin can be increased when it is combined with Etoposide.
EtravirineThe serum concentration of Ciprofloxacin can be increased when it is combined with Etravirine.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Ciprofloxacin.
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Ciprofloxacin.
EzogabineEzogabine may increase the QTc-prolonging activities of Ciprofloxacin.
FamotidineFamotidine may increase the QTc-prolonging activities of Ciprofloxacin.
FelbamateFelbamate may increase the QTc-prolonging activities of Ciprofloxacin.
FelodipineThe serum concentration of Ciprofloxacin can be increased when it is combined with Felodipine.
FentanylThe serum concentration of Ciprofloxacin can be increased when it is combined with Fentanyl.
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Ciprofloxacin.
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Ciprofloxacin.
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Ciprofloxacin.
FingolimodFingolimod may increase the QTc-prolonging activities of Ciprofloxacin.
FlecainideCiprofloxacin may increase the QTc-prolonging activities of Flecainide.
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Ciprofloxacin.
FluconazoleFluconazole may increase the QTc-prolonging activities of Ciprofloxacin.
FluoxetineCiprofloxacin may increase the QTc-prolonging activities of Fluoxetine.
FluoxetineThe serum concentration of Ciprofloxacin can be increased when it is combined with Fluoxetine.
FlupentixolCiprofloxacin may increase the QTc-prolonging activities of Flupentixol.
FlupentixolThe serum concentration of Ciprofloxacin can be increased when it is combined with Flupentixol.
FluphenazineThe serum concentration of Ciprofloxacin can be increased when it is combined with Fluphenazine.
FlurazepamThe serum concentration of Ciprofloxacin can be increased when it is combined with Flurazepam.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Ciprofloxacin.
FluvoxamineThe serum concentration of Ciprofloxacin can be increased when it is combined with Fluvoxamine.
ForasartanForasartan may increase the arrhythmogenic activities of Ciprofloxacin.
FormoterolFormoterol may increase the QTc-prolonging activities of Ciprofloxacin.
FoscarnetFoscarnet may increase the QTc-prolonging activities of Ciprofloxacin.
FosinoprilFosinopril may increase the arrhythmogenic activities of Ciprofloxacin.
FosphenytoinFosphenytoin may increase the QTc-prolonging activities of Ciprofloxacin.
Gadobenic acidCiprofloxacin may increase the QTc-prolonging activities of Gadobenic acid.
GalantamineGalantamine may increase the QTc-prolonging activities of Ciprofloxacin.
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Ciprofloxacin.
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Ciprofloxacin.
GemifloxacinCiprofloxacin may increase the QTc-prolonging activities of Gemifloxacin.
GenisteinThe serum concentration of Ciprofloxacin can be increased when it is combined with Genistein.
GlyburideThe serum concentration of Ciprofloxacin can be increased when it is combined with Glyburide.
GlycerolThe serum concentration of Ciprofloxacin can be increased when it is combined with Glycerol.
GoserelinGoserelin may increase the QTc-prolonging activities of Ciprofloxacin.
Gramicidin DThe serum concentration of Ciprofloxacin can be increased when it is combined with Gramicidin D.
GranisetronCiprofloxacin may increase the QTc-prolonging activities of Granisetron.
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Ciprofloxacin.
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Ciprofloxacin.
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Ciprofloxacin.
HistrelinHistrelin may increase the QTc-prolonging activities of Ciprofloxacin.
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Ciprofloxacin.
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Ciprofloxacin.
HydroxyzineHydroxyzine may increase the QTc-prolonging activities of Ciprofloxacin.
IbandronateIbandronate may increase the QTc-prolonging activities of Ciprofloxacin.
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Ciprofloxacin.
IbutilideCiprofloxacin may increase the QTc-prolonging activities of Ibutilide.
IdelalisibThe serum concentration of Idelalisib can be increased when it is combined with Ciprofloxacin.
IloperidoneCiprofloxacin may increase the QTc-prolonging activities of Iloperidone.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Ciprofloxacin.
ImipramineImipramine may increase the QTc-prolonging activities of Ciprofloxacin.
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Ciprofloxacin.
IndacaterolIndacaterol may increase the QTc-prolonging activities of Ciprofloxacin.
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Ciprofloxacin.
IndapamideIndapamide may increase the QTc-prolonging activities of Ciprofloxacin.
IndinavirThe serum concentration of Ciprofloxacin can be decreased when it is combined with Indinavir.
IndinavirThe serum concentration of Indinavir can be increased when it is combined with Ciprofloxacin.
IndomethacinThe serum concentration of Ciprofloxacin can be increased when it is combined with Indomethacin.
IrbesartanIrbesartan may increase the arrhythmogenic activities of Ciprofloxacin.
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Ciprofloxacin.
IsavuconazoniumThe serum concentration of Ciprofloxacin can be increased when it is combined with Isavuconazonium.
IsofluraneIsoflurane may increase the QTc-prolonging activities of Ciprofloxacin.
IsradipineIsradipine may increase the QTc-prolonging activities of Ciprofloxacin.
ItraconazoleItraconazole may increase the QTc-prolonging activities of Ciprofloxacin.
IvabradineIvabradine may increase the QTc-prolonging activities of Ciprofloxacin.
IvacaftorThe serum concentration of Ciprofloxacin can be increased when it is combined with Ivacaftor.
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Ciprofloxacin.
KetamineThe serum concentration of Ciprofloxacin can be increased when it is combined with Ketamine.
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Ciprofloxacin.
KetoconazoleKetoconazole may increase the QTc-prolonging activities of Ciprofloxacin.
KetoconazoleThe serum concentration of Ketoconazole can be increased when it is combined with Ciprofloxacin.
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Ciprofloxacin.
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Ciprofloxacin.
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Ciprofloxacin.
LapatinibLapatinib may increase the QTc-prolonging activities of Ciprofloxacin.
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Ciprofloxacin.
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Ciprofloxacin.
LenvatinibLenvatinib may increase the QTc-prolonging activities of Ciprofloxacin.
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Ciprofloxacin.
LeuprolideLeuprolide may increase the QTc-prolonging activities of Ciprofloxacin.
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Ciprofloxacin.
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Ciprofloxacin.
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Ciprofloxacin.
LevothyroxineThe serum concentration of Levothyroxine can be decreased when it is combined with Ciprofloxacin.
LidocaineThe serum concentration of Ciprofloxacin can be increased when it is combined with Lidocaine.
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Ciprofloxacin.
LiothyronineThe serum concentration of Liothyronine can be decreased when it is combined with Ciprofloxacin.
LiotrixThe serum concentration of Liotrix can be decreased when it is combined with Ciprofloxacin.
LisinoprilLisinopril may increase the arrhythmogenic activities of Ciprofloxacin.
LithiumLithium may increase the QTc-prolonging activities of Ciprofloxacin.
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Ciprofloxacin.
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Ciprofloxacin.
LopinavirCiprofloxacin may increase the QTc-prolonging activities of Lopinavir.
LopinavirThe serum concentration of Ciprofloxacin can be increased when it is combined with Lopinavir.
LoratadineThe serum concentration of Ciprofloxacin can be increased when it is combined with Loratadine.
LosartanLosartan may increase the arrhythmogenic activities of Ciprofloxacin.
LosartanThe serum concentration of Losartan can be increased when it is combined with Ciprofloxacin.
LovastatinThe serum concentration of Ciprofloxacin can be increased when it is combined with Lovastatin.
LumacaftorThe serum concentration of Ciprofloxacin can be decreased when it is combined with Lumacaftor.
LumefantrineCiprofloxacin may increase the QTc-prolonging activities of Lumefantrine.
MannitolThe serum concentration of Mannitol can be increased when it is combined with Ciprofloxacin.
MaprotilineMaprotiline may increase the QTc-prolonging activities of Ciprofloxacin.
MebendazoleThe serum concentration of Ciprofloxacin can be increased when it is combined with Mebendazole.
MefloquineMefloquine may increase the QTc-prolonging activities of Ciprofloxacin.
Megestrol acetateThe serum concentration of Ciprofloxacin can be increased when it is combined with Megestrol acetate.
MeprobamateThe serum concentration of Ciprofloxacin can be increased when it is combined with Meprobamate.
MethadoneCiprofloxacin may increase the QTc-prolonging activities of Methadone.
MethadoneThe serum concentration of Ciprofloxacin can be increased when it is combined with Methadone.
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Ciprofloxacin.
MethotrimeprazineMethotrimeprazine may increase the QTc-prolonging activities of Ciprofloxacin.
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Ciprofloxacin.
MetoclopramideMetoclopramide may increase the QTc-prolonging activities of Ciprofloxacin.
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Ciprofloxacin.
MetronidazoleMetronidazole may increase the QTc-prolonging activities of Ciprofloxacin.
MibefradilThe serum concentration of Ciprofloxacin can be increased when it is combined with Mibefradil.
MiconazoleThe serum concentration of Ciprofloxacin can be increased when it is combined with Miconazole.
MidazolamThe serum concentration of Ciprofloxacin can be decreased when it is combined with Midazolam.
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Ciprofloxacin.
MifepristoneMifepristone may increase the QTc-prolonging activities of Ciprofloxacin.
MirabegronMirabegron may increase the QTc-prolonging activities of Ciprofloxacin.
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Ciprofloxacin.
MirtazapineMirtazapine may increase the QTc-prolonging activities of Ciprofloxacin.
MitomycinThe serum concentration of Ciprofloxacin can be increased when it is combined with Mitomycin.
MitoxantroneThe serum concentration of Ciprofloxacin can be decreased when it is combined with Mitoxantrone.
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Ciprofloxacin.
MoexiprilMoexipril may increase the arrhythmogenic activities of Ciprofloxacin.
MorphineThe serum concentration of Morphine can be increased when it is combined with Ciprofloxacin.
MoxifloxacinMoxifloxacin may increase the QTc-prolonging activities of Ciprofloxacin.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Ciprofloxacin.
NadololThe serum concentration of Nadolol can be increased when it is combined with Ciprofloxacin.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Ciprofloxacin.
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Ciprofloxacin.
NaltrexoneThe serum concentration of Ciprofloxacin can be increased when it is combined with Naltrexone.
NaringeninThe serum concentration of Ciprofloxacin can be increased when it is combined with Naringenin.
NefazodoneThe serum concentration of Ciprofloxacin can be decreased when it is combined with Nefazodone.
NelfinavirNelfinavir may increase the QTc-prolonging activities of Ciprofloxacin.
NelfinavirThe serum concentration of Nelfinavir can be increased when it is combined with Ciprofloxacin.
NeostigmineThe serum concentration of Ciprofloxacin can be increased when it is combined with Neostigmine.
NicardipineNicardipine may increase the QTc-prolonging activities of Ciprofloxacin.
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Ciprofloxacin.
NifedipineThe serum concentration of Ciprofloxacin can be decreased when it is combined with Nifedipine.
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Ciprofloxacin.
NilotinibCiprofloxacin may increase the QTc-prolonging activities of Nilotinib.
NilotinibThe serum concentration of Ciprofloxacin can be increased when it is combined with Nilotinib.
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Ciprofloxacin.
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Ciprofloxacin.
NisoldipineThe serum concentration of Ciprofloxacin can be increased when it is combined with Nisoldipine.
NitrazepamThe serum concentration of Ciprofloxacin can be increased when it is combined with Nitrazepam.
NitrendipineThe serum concentration of Ciprofloxacin can be increased when it is combined with Nitrendipine.
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Ciprofloxacin.
NorethisteroneThe serum concentration of Ciprofloxacin can be decreased when it is combined with Norethisterone.
NorfloxacinNorfloxacin may increase the QTc-prolonging activities of Ciprofloxacin.
NortriptylineNortriptyline may increase the QTc-prolonging activities of Ciprofloxacin.
OctreotideOctreotide may increase the QTc-prolonging activities of Ciprofloxacin.
OfloxacinCiprofloxacin may increase the QTc-prolonging activities of Ofloxacin.
OlanzapineOlanzapine may increase the QTc-prolonging activities of Ciprofloxacin.
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Ciprofloxacin.
OlmesartanOlmesartan may increase the arrhythmogenic activities of Ciprofloxacin.
OlodaterolOlodaterol may increase the QTc-prolonging activities of Ciprofloxacin.
OmapatrilatOmapatrilat may increase the arrhythmogenic activities of Ciprofloxacin.
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Ciprofloxacin.
OmeprazoleThe serum concentration of Ciprofloxacin can be increased when it is combined with Omeprazole.
OndansetronCiprofloxacin may increase the QTc-prolonging activities of Ondansetron.
OsimertinibThe serum concentration of Osimertinib can be increased when it is combined with Ciprofloxacin.
OuabainOuabain may decrease the cardiotoxic activities of Ciprofloxacin.
OxytocinOxytocin may increase the QTc-prolonging activities of Ciprofloxacin.
P-NitrophenolThe serum concentration of Ciprofloxacin can be increased when it is combined with P-Nitrophenol.
PaclitaxelThe serum concentration of Ciprofloxacin can be increased when it is combined with Paclitaxel.
PaliperidoneCiprofloxacin may increase the QTc-prolonging activities of Paliperidone.
Palmitic AcidThe serum concentration of Ciprofloxacin can be increased when it is combined with Palmitic Acid.
PanobinostatPanobinostat may increase the QTc-prolonging activities of Ciprofloxacin.
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Ciprofloxacin.
PantoprazoleThe serum concentration of Ciprofloxacin can be increased when it is combined with Pantoprazole.
ParoxetineParoxetine may increase the QTc-prolonging activities of Ciprofloxacin.
PasireotidePasireotide may increase the QTc-prolonging activities of Ciprofloxacin.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Ciprofloxacin.
PazopanibPazopanib may increase the QTc-prolonging activities of Ciprofloxacin.
PentamidineCiprofloxacin may increase the QTc-prolonging activities of Pentamidine.
PerflutrenCiprofloxacin may increase the QTc-prolonging activities of Perflutren.
PerindoprilPerindopril may increase the arrhythmogenic activities of Ciprofloxacin.
PhenobarbitalThe serum concentration of Ciprofloxacin can be decreased when it is combined with Phenobarbital.
PhenobarbitalThe serum concentration of Phenobarbital can be increased when it is combined with Ciprofloxacin.
PhenytoinThe therapeutic efficacy of Phenytoin can be decreased when used in combination with Ciprofloxacin.
Picosulfuric acidThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Ciprofloxacin.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Ciprofloxacin.
PirfenidoneThe serum concentration of Pirfenidone can be increased when it is combined with Ciprofloxacin.
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Ciprofloxacin.
Platelet Activating FactorThe serum concentration of Ciprofloxacin can be decreased when it is combined with Platelet Activating Factor.
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Ciprofloxacin.
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Ciprofloxacin.
PosaconazolePosaconazole may increase the QTc-prolonging activities of Ciprofloxacin.
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Ciprofloxacin.
PrazosinThe serum concentration of Ciprofloxacin can be increased when it is combined with Prazosin.
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Ciprofloxacin.
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Ciprofloxacin.
PrimaquineCiprofloxacin may increase the QTc-prolonging activities of Primaquine.
ProbenecidThe serum concentration of Ciprofloxacin can be increased when it is combined with Probenecid.
ProcainamideCiprofloxacin may increase the QTc-prolonging activities of Procainamide.
ProgesteroneThe serum concentration of Ciprofloxacin can be decreased when it is combined with Progesterone.
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Ciprofloxacin.
PromazinePromazine may increase the QTc-prolonging activities of Ciprofloxacin.
PromethazinePromethazine may increase the QTc-prolonging activities of Ciprofloxacin.
PropafenoneCiprofloxacin may increase the QTc-prolonging activities of Propafenone.
PropafenoneThe serum concentration of Ciprofloxacin can be increased when it is combined with Propafenone.
PropofolPropofol may increase the QTc-prolonging activities of Ciprofloxacin.
PropranololThe serum concentration of Propranolol can be increased when it is combined with Ciprofloxacin.
ProtriptylineProtriptyline may increase the QTc-prolonging activities of Ciprofloxacin.
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Ciprofloxacin.
QuercetinThe serum concentration of Ciprofloxacin can be increased when it is combined with Quercetin.
QuetiapineCiprofloxacin may increase the QTc-prolonging activities of Quetiapine.
QuinacrineThe serum concentration of Ciprofloxacin can be increased when it is combined with Quinacrine.
QuinaprilQuinapril may increase the arrhythmogenic activities of Ciprofloxacin.
QuinidineCiprofloxacin may increase the QTc-prolonging activities of Quinidine.
QuinidineThe serum concentration of Ciprofloxacin can be increased when it is combined with Quinidine.
QuinineCiprofloxacin may increase the QTc-prolonging activities of Quinine.
QuinineThe serum concentration of Ciprofloxacin can be increased when it is combined with Quinine.
RamiprilRamipril may increase the arrhythmogenic activities of Ciprofloxacin.
RanitidineThe serum concentration of Ciprofloxacin can be increased when it is combined with Ranitidine.
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Ciprofloxacin.
ReboxetineThe serum concentration of Ciprofloxacin can be increased when it is combined with Reboxetine.
RegorafenibThe serum concentration of Ciprofloxacin can be increased when it is combined with Regorafenib.
RescinnamineRescinnamine may increase the arrhythmogenic activities of Ciprofloxacin.
ReserpineThe serum concentration of Ciprofloxacin can be decreased when it is combined with Reserpine.
ReserpineThe serum concentration of Reserpine can be increased when it is combined with Ciprofloxacin.
RifampicinThe serum concentration of Ciprofloxacin can be decreased when it is combined with Rifampicin.
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Ciprofloxacin.
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Ciprofloxacin.
RilpivirineRilpivirine may increase the QTc-prolonging activities of Ciprofloxacin.
RisperidoneRisperidone may increase the QTc-prolonging activities of Ciprofloxacin.
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Ciprofloxacin.
RitonavirRitonavir may increase the QTc-prolonging activities of Ciprofloxacin.
RitonavirThe serum concentration of Ritonavir can be increased when it is combined with Ciprofloxacin.
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Ciprofloxacin.
RoflumilastThe serum concentration of Roflumilast can be increased when it is combined with Ciprofloxacin.
RolapitantThe serum concentration of Ciprofloxacin can be increased when it is combined with Rolapitant.
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Ciprofloxacin.
RopiniroleThe serum concentration of Ropinirole can be increased when it is combined with Ciprofloxacin.
RopivacaineThe serum concentration of Ropivacaine can be increased when it is combined with Ciprofloxacin.
SalbutamolSalbutamol may increase the QTc-prolonging activities of Ciprofloxacin.
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Ciprofloxacin.
SalmeterolSalmeterol may increase the QTc-prolonging activities of Ciprofloxacin.
SaprisartanSaprisartan may increase the arrhythmogenic activities of Ciprofloxacin.
SaquinavirThe serum concentration of Ciprofloxacin can be decreased when it is combined with Saquinavir.
SaquinavirThe serum concentration of Saquinavir can be increased when it is combined with Ciprofloxacin.
SaralasinSaralasin may increase the arrhythmogenic activities of Ciprofloxacin.
ScopolamineThe serum concentration of Ciprofloxacin can be increased when it is combined with Scopolamine.
SelegilineThe serum concentration of Ciprofloxacin can be increased when it is combined with Selegiline.
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Ciprofloxacin.
SertralineSertraline may increase the QTc-prolonging activities of Ciprofloxacin.
SevofluraneSevoflurane may increase the QTc-prolonging activities of Ciprofloxacin.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Ciprofloxacin.
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Ciprofloxacin.
SimvastatinThe serum concentration of Ciprofloxacin can be increased when it is combined with Simvastatin.
SirolimusThe serum concentration of Ciprofloxacin can be decreased when it is combined with Sirolimus.
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Ciprofloxacin.
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Ciprofloxacin.
SolifenacinSolifenacin may increase the QTc-prolonging activities of Ciprofloxacin.
SorafenibSorafenib may increase the QTc-prolonging activities of Ciprofloxacin.
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Ciprofloxacin.
SotalolCiprofloxacin may increase the QTc-prolonging activities of Sotalol.
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Ciprofloxacin.
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Ciprofloxacin.
SpiraprilSpirapril may increase the arrhythmogenic activities of Ciprofloxacin.
SpironolactoneSpironolactone may increase the arrhythmogenic activities of Ciprofloxacin.
St. John's WortThe serum concentration of Ciprofloxacin can be decreased when it is combined with St. John's Wort.
StaurosporineThe serum concentration of Ciprofloxacin can be increased when it is combined with Staurosporine.
StreptozocinThe serum concentration of Ciprofloxacin can be decreased when it is combined with Streptozocin.
SulfamethoxazoleSulfamethoxazole may increase the QTc-prolonging activities of Ciprofloxacin.
SulfinpyrazoneThe serum concentration of Ciprofloxacin can be increased when it is combined with Sulfinpyrazone.
SulfisoxazoleSulfisoxazole may increase the QTc-prolonging activities of Ciprofloxacin.
SumatriptanThe serum concentration of Ciprofloxacin can be increased when it is combined with Sumatriptan.
SunitinibSunitinib may increase the QTc-prolonging activities of Ciprofloxacin.
TacrineThe serum concentration of Ciprofloxacin can be increased when it is combined with Tacrine.
TacrolimusThe serum concentration of Ciprofloxacin can be decreased when it is combined with Tacrolimus.
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Ciprofloxacin.
TamoxifenTamoxifen may increase the QTc-prolonging activities of Ciprofloxacin.
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Ciprofloxacin.
TasosartanTasosartan may increase the arrhythmogenic activities of Ciprofloxacin.
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Ciprofloxacin.
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Ciprofloxacin.
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Ciprofloxacin.
TelavancinCiprofloxacin may increase the QTc-prolonging activities of Telavancin.
TelithromycinCiprofloxacin may increase the QTc-prolonging activities of Telithromycin.
TelmisartanTelmisartan may increase the arrhythmogenic activities of Ciprofloxacin.
TemocaprilTemocapril may increase the arrhythmogenic activities of Ciprofloxacin.
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Ciprofloxacin.
TerazosinThe serum concentration of Ciprofloxacin can be increased when it is combined with Terazosin.
TerbutalineTerbutaline may increase the QTc-prolonging activities of Ciprofloxacin.
TerfenadineThe serum concentration of Ciprofloxacin can be increased when it is combined with Terfenadine.
TesmilifeneThe serum concentration of Ciprofloxacin can be decreased when it is combined with Tesmilifene.
TestosteroneThe serum concentration of Ciprofloxacin can be increased when it is combined with Testosterone.
TetrabenazineCiprofloxacin may increase the QTc-prolonging activities of Tetrabenazine.
ThioridazineCiprofloxacin may increase the QTc-prolonging activities of Thioridazine.
ThiothixeneThiothixene may increase the QTc-prolonging activities of Ciprofloxacin.
Thyroid, porcineThe serum concentration of Thyroid, porcine can be decreased when it is combined with Ciprofloxacin.
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Ciprofloxacin.
TimololThe serum concentration of Timolol can be increased when it is combined with Ciprofloxacin.
TizanidineTizanidine may increase the QTc-prolonging activities of Ciprofloxacin.
TolterodineTolterodine may increase the QTc-prolonging activities of Ciprofloxacin.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Ciprofloxacin.
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Ciprofloxacin.
ToremifeneCiprofloxacin may increase the QTc-prolonging activities of Toremifene.
TrandolaprilTrandolapril may increase the arrhythmogenic activities of Ciprofloxacin.
TrastuzumabTrastuzumab may increase the cardiotoxic activities of Ciprofloxacin.
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Ciprofloxacin.
TrazodoneTrazodone may increase the QTc-prolonging activities of Ciprofloxacin.
TreprostinilTreprostinil may increase the QTc-prolonging activities of Ciprofloxacin.
TrifluoperazineThe serum concentration of Ciprofloxacin can be increased when it is combined with Trifluoperazine.
TriflupromazineThe serum concentration of Ciprofloxacin can be increased when it is combined with Triflupromazine.
TrimethoprimTrimethoprim may increase the QTc-prolonging activities of Ciprofloxacin.
TrimipramineTrimipramine may increase the QTc-prolonging activities of Ciprofloxacin.
TriptorelinTriptorelin may increase the QTc-prolonging activities of Ciprofloxacin.
TroleandomycinThe serum concentration of Ciprofloxacin can be increased when it is combined with Troleandomycin.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Ciprofloxacin.
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Ciprofloxacin.
ValsartanValsartan may increase the arrhythmogenic activities of Ciprofloxacin.
VandetanibCiprofloxacin may increase the QTc-prolonging activities of Vandetanib.
VardenafilVardenafil may increase the QTc-prolonging activities of Ciprofloxacin.
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Ciprofloxacin.
VemurafenibCiprofloxacin may increase the QTc-prolonging activities of Vemurafenib.
VenlafaxineVenlafaxine may increase the QTc-prolonging activities of Ciprofloxacin.
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Ciprofloxacin.
VerapamilThe serum concentration of Ciprofloxacin can be decreased when it is combined with Verapamil.
VerapamilThe serum concentration of Verapamil can be increased when it is combined with Ciprofloxacin.
VilanterolVilanterol may increase the QTc-prolonging activities of Ciprofloxacin.
VinblastineThe serum concentration of Ciprofloxacin can be decreased when it is combined with Vinblastine.
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Ciprofloxacin.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Ciprofloxacin.
VincristineThe serum concentration of Ciprofloxacin can be decreased when it is combined with Vincristine.
VinorelbineThe serum concentration of Ciprofloxacin can be increased when it is combined with Vinorelbine.
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Ciprofloxacin.
VoriconazoleVoriconazole may increase the QTc-prolonging activities of Ciprofloxacin.
VorinostatVorinostat may increase the QTc-prolonging activities of Ciprofloxacin.
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Ciprofloxacin.
ZimelidineThe serum concentration of Ciprofloxacin can be increased when it is combined with Zimelidine.
ZiprasidoneCiprofloxacin may increase the QTc-prolonging activities of Ziprasidone.
ZuclopenthixolCiprofloxacin may increase the QTc-prolonging activities of Zuclopenthixol.
Food Interactions
  • Avoid excessive quantities of coffee or tea (Caffeine).
  • Avoid milk, calcium containing dairy products, iron, magnesium, zinc, antacids, or aluminum salts 2 hours before or 6 hours after using antacids while on this medication.
  • Take with a full glass of water.
  • Take without regard to meals.

Targets

Kind
Protein
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Pharmacological action
yes
Actions
inhibitor
General Function:
Dna topoisomerase type ii (atp-hydrolyzing) activity
Specific Function:
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Gene Name:
parC
Uniprot ID:
P43702
Molecular Weight:
83366.24 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Chaudhry U, Ray K, Bala M, Saluja D: Mutation patterns in gyrA and parC genes of ciprofloxacin resistant isolates of Neisseria gonorrhoeae from India. Sex Transm Infect. 2002 Dec;78(6):440-4. [PubMed:12473806 ]
  4. Lee JK, Lee YS, Park YK, Kim BS: Mutations in the gyrA and parC genes in ciprofloxacin-resistant clinical isolates of Acinetobacter baumannii in Korea. Microbiol Immunol. 2005;49(7):647-53. [PubMed:16034208 ]
  5. Leavis HL, Willems RJ, Top J, Bonten MJ: High-level ciprofloxacin resistance from point mutations in gyrA and parC confined to global hospital-adapted clonal lineage CC17 of Enterococcus faecium. J Clin Microbiol. 2006 Mar;44(3):1059-64. [PubMed:16517894 ]
  6. Drlica K, Zhao X: DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev. 1997 Sep;61(3):377-92. [PubMed:9293187 ]
Kind
Protein
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Pharmacological action
yes
Actions
inhibitor
General Function:
Dna topoisomerase type ii (atp-hydrolyzing) activity
Specific Function:
DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.
Gene Name:
gyrA
Uniprot ID:
P43700
Molecular Weight:
97817.145 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Chaudhry U, Ray K, Bala M, Saluja D: Mutation patterns in gyrA and parC genes of ciprofloxacin resistant isolates of Neisseria gonorrhoeae from India. Sex Transm Infect. 2002 Dec;78(6):440-4. [PubMed:12473806 ]
  4. Abdelbaqi K, Menard A, Prouzet-Mauleon V, Bringaud F, Lehours P, Megraud F: Nucleotide sequence of the gyrA gene of Arcobacter species and characterization of human ciprofloxacin-resistant clinical isolates. FEMS Immunol Med Microbiol. 2007 Apr;49(3):337-45. [PubMed:17378897 ]
  5. Taylor DE, Chau AS: Cloning and nucleotide sequence of the gyrA gene from Campylobacter fetus subsp. fetus ATCC 27374 and characterization of ciprofloxacin-resistant laboratory and clinical isolates. Antimicrob Agents Chemother. 1997 Mar;41(3):665-71. [PubMed:9056011 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Ubiquitin binding
Specific Function:
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (By similarity).
Gene Name:
TOP2A
Uniprot ID:
P11388
Molecular Weight:
174383.88 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  2. Robinson MJ, Martin BA, Gootz TD, McGuirk PR, Osheroff N: Effects of novel fluoroquinolones on the catalytic activities of eukaryotic topoisomerase II: Influence of the C-8 fluorine group. Antimicrob Agents Chemother. 1992 Apr;36(4):751-6. [PubMed:1323952 ]
  3. Hussy P, Maass G, Tummler B, Grosse F, Schomburg U: Effect of 4-quinolones and novobiocin on calf thymus DNA polymerase alpha primase complex, topoisomerases I and II, and growth of mammalian lymphoblasts. Antimicrob Agents Chemother. 1986 Jun;29(6):1073-8. [PubMed:3015015 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
Specific Function:
Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoforms USO have no channel activity by themself, but modulates channel characteristics by forming heterotetramers with other isoforms which are r...
Gene Name:
KCNH2
Uniprot ID:
Q12809
Molecular Weight:
126653.52 Da
References
  1. Keseru GM: Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods. Bioorg Med Chem Lett. 2003 Aug 18;13(16):2773-5. [PubMed:12873512 ]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
unknown
General Function:
Identical protein binding
Specific Function:
DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.
Gene Name:
gyrA
Uniprot ID:
P0AES4
Molecular Weight:
96962.63 Da
References
  1. Hubschwerlen C, Specklin JL, Baeschlin DK, Borer Y, Haefeli S, Sigwalt C, Schroeder S, Locher HH: Structure-activity relationship in the oxazolidinone-quinolone hybrid series: influence of the central spacer on the antibacterial activity and the mode of action. Bioorg Med Chem Lett. 2003 Dec 1;13(23):4229-33. [PubMed:14623007 ]
Kind
Protein
Organism
Staphylococcus aureus
Pharmacological action
unknown
General Function:
Dna topoisomerase type ii (atp-hydrolyzing) activity
Specific Function:
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Gene Name:
parC
Uniprot ID:
P0C1U9
Molecular Weight:
91040.465 Da
References
  1. Wiles JA, Song Y, Wang Q, Lucien E, Hashimoto A, Cheng J, Marlor CW, Ou Y, Podos SD, Thanassi JA, Thoma CL, Deshpande M, Pucci MJ, Bradbury BJ: Biological evaluation of isothiazoloquinolones containing aromatic heterocycles at the 7-position: In vitro activity of a series of potent antibacterial agents that are effective against methicillin-resistant Staphylococcus aureus. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1277-81. Epub 2005 Dec 7. [PubMed:16337789 ]
Kind
Protein
Organism
Bacillus subtilis (strain 168)
Pharmacological action
unknown
General Function:
Magnesium ion binding
Specific Function:
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Gene Name:
parE
Uniprot ID:
Q59192
Molecular Weight:
73006.17 Da
References
  1. Butler MM, Lamarr WA, Foster KA, Barnes MH, Skow DJ, Lyden PT, Kustigian LM, Zhi C, Brown NC, Wright GE, Bowlin TL: Antibacterial activity and mechanism of action of a novel anilinouracil-fluoroquinolone hybrid compound. Antimicrob Agents Chemother. 2007 Jan;51(1):119-27. Epub 2006 Oct 30. [PubMed:17074800 ]
Kind
Protein
Organism
Bacillus subtilis (strain 168)
Pharmacological action
unknown
General Function:
Dna topoisomerase type ii (atp-hydrolyzing) activity
Specific Function:
DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.
Gene Name:
gyrA
Uniprot ID:
P05653
Molecular Weight:
92098.19 Da
References
  1. Butler MM, Lamarr WA, Foster KA, Barnes MH, Skow DJ, Lyden PT, Kustigian LM, Zhi C, Brown NC, Wright GE, Bowlin TL: Antibacterial activity and mechanism of action of a novel anilinouracil-fluoroquinolone hybrid compound. Antimicrob Agents Chemother. 2007 Jan;51(1):119-27. Epub 2006 Oct 30. [PubMed:17074800 ]
Kind
Protein
Organism
Escherichia coli
Pharmacological action
unknown
General Function:
Drug transmembrane transporter activity
Specific Function:
Multidrug efflux pump that functions probably as a Na(+)/drug antiporter.
Gene Name:
mdtK
Uniprot ID:
C3T8E2
Molecular Weight:
49446.52 Da
References
  1. Long F, Rouquette-Loughlin C, Shafer WM, Yu EW: Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli. Antimicrob Agents Chemother. 2008 Sep;52(9):3052-60. doi: 10.1128/AAC.00475-08. Epub 2008 Jun 30. [PubMed:18591276 ]
Kind
Protein
Organism
Mycobacterium tuberculosis
Pharmacological action
unknown
General Function:
Dna topoisomerase type ii (atp-hydrolyzing) activity
Specific Function:
Not Available
Gene Name:
Not Available
Uniprot ID:
B4YQT9
Molecular Weight:
17024.015 Da
References
  1. Karkare S, Chung TT, Collin F, Mitchenall LA, McKay AR, Greive SJ, Meyer JJ, Lall N, Maxwell A: The naphthoquinone diospyrin is an inhibitor of DNA gyrase with a novel mechanism of action. J Biol Chem. 2013 Feb 15;288(7):5149-56. doi: 10.1074/jbc.M112.419069. Epub 2012 Dec 28. [PubMed:23275348 ]
Kind
Protein
Organism
Staphylococcus aureus
Pharmacological action
unknown
General Function:
Dna topoisomerase type ii (atp-hydrolyzing) activity
Specific Function:
DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.
Gene Name:
gyrA
Uniprot ID:
P20831
Molecular Weight:
99620.34 Da
References
  1. Surivet JP, Zumbrunn C, Rueedi G, Hubschwerlen C, Bur D, Bruyere T, Locher H, Ritz D, Keck W, Seiler P, Kohl C, Gauvin JC, Mirre A, Kaegi V, Dos Santos M, Gaertner M, Delers J, Enderlin-Paput M, Boehme M: Design, synthesis, and characterization of novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram-positive activity. J Med Chem. 2013 Sep 26;56(18):7396-415. doi: 10.1021/jm400963y. Epub 2013 Sep 11. [PubMed:23968485 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Wang E, Lew K, Barecki M, Casciano CN, Clement RP, Johnson WW: Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4. Chem Res Toxicol. 2001 Dec;14(12):1596-603. [PubMed:11743742 ]
  2. Yamaguchi H, Yano I, Saito H, Inui K: Effect of cisplatin-induced acute renal failure on bioavailability and intestinal secretion of quinolone antibacterial drugs in rats. Pharm Res. 2004 Feb;21(2):330-8. [PubMed:15032316 ]
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Drug created on June 13, 2005 07:24 / Updated on October 01, 2016 03:35