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transporters (2)
for drugs
Identification
Name Acetic acid
Accession Number DB03166 (DB04184, EXPT00423)
Type small molecule
Groups approved
Description

Acetic acid is a product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed) Acetic acid otic (for the ear) is an antibiotic that treats infections caused by bacteria or fungus.
Structure Thumb
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Display: 2D Structure | 3D Structure
Synonyms
Ethanoat
Ethanoate
Salts Not Available
Brand names
Name Company
Acetasol
Borofair Major Pharma
Volsol
Brand mixtures Not Available
Categories
  • Antibacterial Agents
  • Indicators and Reagents
CAS number 64-19-7
Weight Average: 59.044
Monoisotopic: 59.01330434
Chemical Formula C2H3O2
InChI Key InChIKey=QTBSBXVTEAMEQO-UHFFFAOYSA-M
InChI
InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1
Plain Text
IUPAC Name
acetate
SMILES
CC([O-])=O
Plain Text
Mass Spec Not Available
Taxonomy
Kingdom Not Available
Classes Not Available
Substructures Not Available
Pharmacology
Indication Used to treat infections in the ear canal.
Pharmacodynamics Not Available
Mechanism of action Not Available
Absorption Not Available
Volume of distribution Not Available
Protein binding Not Available
Metabolism
Not Available
Route of elimination Not Available
Half life Not Available
Clearance Not Available
Toxicity Not Available
Affected organisms
  • Bacteria
Pathways Not Available
Pharmacoeconomics
Manufacturers Not Available
Packagers
Dosage forms Not Available
Prices Not Available
Patents Not Available
Properties
State solid
Experimental Properties
Property Value Source
melting point 16.6 °C PhysProp
boiling point 117.9 °C PhysProp
water solubility 1E+006 mg/L (at 25 °C) MERCK INDEX (1996)
logP -0.17 HANSCH,C ET AL. (1995)
logS 1.22 ADME Research, USCD
pKa 4.76 (at 25 °C) SERJEANT,EP & DEMPSEY,B (1979)
Predicted Properties
Property Value Source
water solubility 4.90e+02 g/l ALOGPS
logP -0.29 ALOGPS
logP -0.22 ChemAxon
logS 0.8 ALOGPS
pKa (strongest acidic) 4.54 ChemAxon
physiological charge -1 ChemAxon
hydrogen acceptor count 2 ChemAxon
hydrogen donor count 0 ChemAxon
polar surface area 40.13 ChemAxon
rotatable bond count 0 ChemAxon
refractivity 23.48 ChemAxon
polarizability 4.96 ChemAxon
References
Synthesis Reference Not Available
General Reference
  1. eMedicine
External Links
Resource Link
KEGG Drug D00010 Link_out
KEGG Compound C00033 Link_out
ChEBI 30089 Link_out
ChEMBL 30089 Link_out
PharmGKB PA448021 Link_out
IUPHAR 1058 Link_out
Guide to Pharmacology 1058 Link_out
HET ACY Link_out
Drugs.com http://www.drugs.com/cdi/acetic-acid-solution.html Link_out
Wikipedia http://en.wikipedia.org/wiki/Acetic_acid Link_out
ATC Codes
  • S02AA10
  • G01AD02
AHFS Codes Not Available
PDB Entries
FDA label Not Available
MSDS Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available
Transporters

1. Solute carrier organic anion transporter family member 2B1

Actions: substrate, inhibitor

Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost

UniProt ID: O94956 Link_out
Gene: SLCO2B1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Kobayashi D, Nozawa T, Imai K, Nezu J, Tsuji A, Tamai I: Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane. J Pharmacol Exp Ther. 2003 Aug;306(2):703-8. Epub 2003 Apr 30. Pubmed
  2. Nozawa T, Imai K, Nezu J, Tsuji A, Tamai I: Functional characterization of pH-sensitive organic anion transporting polypeptide OATP-B in human. J Pharmacol Exp Ther. 2004 Feb;308(2):438-45. Epub 2003 Nov 10. Pubmed

2. Monocarboxylate transporter 1

Actions: substrate

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate

UniProt ID: P53985 Link_out
Gene: SLC16A1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Tamai I, Sai Y, Ono A, Kido Y, Yabuuchi H, Takanaga H, Satoh E, Ogihara T, Amano O, Izeki S, Tsuji A: Immunohistochemical and functional characterization of pH-dependent intestinal absorption of weak organic acids by the monocarboxylic acid transporter MCT1. J Pharm Pharmacol. 1999 Oct;51(10):1113-21. Pubmed
Comments
Drug created on June 13, 2005 07:24 / Updated on February 08, 2013 16:21