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Identification
NameChlorothiazide
Accession NumberDB00880  (APRD00721)
TypeSmall Molecule
GroupsApproved
Description

A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812)

Structure
Thumb
Synonyms
SynonymLanguageCode
6-Chloro-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[1,2,4]thiadiazine-7-sulfonic acid amideNot AvailableNot Available
6-chloro-7-Sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxideNot AvailableNot Available
ChlorothiazidNot AvailableNot Available
ChlorothiazideNot AvailableNot Available
ChlorothiazidumNot AvailablePH: Ph. Eur. 7, Ph. Int. 2
ChlorthiazideNot AvailableNot Available
ClorotiazidaNot AvailableNot Available
MechlozidNot AvailableIS
UrofluxNot AvailableIS
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Chlorothiazide Sodiuminjection500 mgintravenousAkorn, Inc.2012-08-13Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diurilsuspension250 mg/5mLoralSalix Pharmaceuticals, Inc.1962-02-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Chlorothiazidetablet250 mgoralWest ward Pharmaceutical Corp2005-08-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Chlorothiazidetablet500 mgoralWest ward Pharmaceutical Corp2005-08-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Chlorothiazidetablet250 mgoralMylan Pharmaceuticals Inc.1975-06-26Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Chlorothiazidetablet500 mgoralMylan Pharmaceuticals Inc.1975-07-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Chlorothiazide Sodiuminjection, powder, lyophilized, for solution500 mg/18mLintravenousSun Pharma Global FZE2011-08-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Chlorothiazidetablet250 mgoralGolden State Medical Supply, Inc.2005-08-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Chlorothiazidetablet500 mgoralGolden State Medical Supply, Inc.2005-08-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Chlorothiazideinjection, powder, lyophilized, for solution500 mg/18mLintravenousFresenius Kabi USA, LLC2009-10-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Chlorothiazideinjection, powder, lyophilized, for solution500 mg/18mLintravenousAPP Pharmaceuticals, LLC2009-10-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Chlorothiazideinjection, powder, lyophilized, for solution500 mg/18mLintravenousFresenius Kabi USA, LLC2009-10-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Chlorothiazide Sodiuminjection, powder, lyophilized, for solution500 mg/18mLintravenousMylan Institutional LLC2014-08-08Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Over the Counter ProductsNot Available
International BrandsNot Available
Brand mixtures
Brand NameIngredients
Supres 150 TabChlorothiazide + Methyldopa
Supres 250 TabChlorothiazide + Methyldopa
Salts
Name/CASStructureProperties
Chlorothiazide Sodium
ThumbNot applicableDBSALT000926
Categories
CAS number58-94-6
WeightAverage: 295.723
Monoisotopic: 294.948824782
Chemical FormulaC7H6ClN3O4S2
InChI KeyJBMKAUGHUNFTOL-UHFFFAOYSA-N
InChI
InChI=1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13)
IUPAC Name
6-chloro-1,1-dioxo-4H-1λ⁶,2,4-benzothiadiazine-7-sulfonamide
SMILES
NS(=O)(=O)C1=C(Cl)C=C2NC=NS(=O)(=O)C2=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as benzothiadiazines. These are organic compounds containing a benzene fused to a thiadiazine ring (a six-member ring with two nitrogen atoms and a sulfur atom).
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassThiadiazines
Sub ClassBenzothiadiazines
Direct ParentBenzothiadiazines
Alternative Parents
Substituents
  • Benzothiadiazine
  • Benzenesulfonamide
  • Chlorobenzene
  • Benzenoid
  • Aryl halide
  • Aryl chloride
  • Aminosulfonyl compound
  • Sulfonyl
  • Sulfonic acid derivative
  • Sulfonamide
  • Azacycle
  • Amidine
  • Hydrocarbon derivative
  • Organosulfur compound
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationChlorothiazide is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. It is also indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs in the more severe forms of hypertension.
PharmacodynamicsLike other thiazides, chlorothiazide promotes water loss from the body (diuretics). It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue. Chlorothiazide affects the distal renal tubular mechanism of electrolyte reabsorption. At maximal therapeutic dosages, all thiazides are approximately equal in their diuretic efficacy. Chlorothiazide increases excretion of sodium and chloride in approximately equivalent amounts. Natriuresis may be accompanied by some loss of potassium and bicarbonate. After oral doses, 10-15 percent of the dose is excreted unchanged in the urine. Chlorothiazide crosses the placental but not the blood-brain barrier and is excreted in breast milk.
Mechanism of actionAs a diuretic, chlorothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like chlorothiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of chlorothiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle.
AbsorptionRapidly absorbed following oral administration.
Volume of distributionNot Available
Protein bindingApproximately 40% bound to plasma proteins.
Metabolism

Chlorothiazide is not metabolized but is eliminated rapidly by the kidney.

Route of eliminationChlorothiazide is not metabolized but is eliminated rapidly by the kidney. After oral doses, 10 to 15 percent of the dose is excreted unchanged in the urine. Chlorothiazide crosses the placental but not the blood-brain barrier and is excreted in breast milk.
Half life45-120 minutes
ClearanceNot Available
ToxicityOral, rat LD50: > 10 g/kg. Signs of overdose include those caused by electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration resulting from excessive diuresis. If digitalis has also been administered hypokalemia may accentuate cardiac arrhythmias.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9119
Blood Brain Barrier-0.9506
Caco-2 permeable-0.7368
P-glycoprotein substrateNon-substrate0.706
P-glycoprotein inhibitor INon-inhibitor0.8482
P-glycoprotein inhibitor IINon-inhibitor0.8381
Renal organic cation transporterNon-inhibitor0.8177
CYP450 2C9 substrateNon-substrate0.755
CYP450 2D6 substrateNon-substrate0.8379
CYP450 3A4 substrateNon-substrate0.6308
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 substrateNon-inhibitor0.9071
CYP450 2D6 substrateNon-inhibitor0.923
CYP450 2C19 substrateNon-inhibitor0.9382
CYP450 3A4 substrateNon-inhibitor0.8901
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8658
Ames testNon AMES toxic0.9132
CarcinogenicityNon-carcinogens0.7792
BiodegradationNot ready biodegradable1.0
Rat acute toxicity1.5023 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9654
hERG inhibition (predictor II)Non-inhibitor0.9352
Pharmacoeconomics
Manufacturers
  • Salix pharmaceuticals inc
  • Abc holding corp
  • Lederle laboratories div american cyanamid co
  • Mylan pharmaceuticals inc
  • Sandoz inc
  • Watson laboratories inc
  • West ward pharmaceutical corp
  • Lundbeck inc
  • App pharmaceuticals llc
Packagers
Dosage forms
FormRouteStrength
Injectionintravenous500 mg
Injection, powder, lyophilized, for solutionintravenous500 mg/18mL
Suspensionoral250 mg/5mL
Tabletoral250 mg
Tabletoral500 mg
Prices
Unit descriptionCostUnit
Diuril sodium 500 mg vial519.62USD vial
Chlorothiazide sod 500 mg vial357.24USD vial
Microzide 12.5 mg capsule0.95USD capsule
Aldoclor 250-250 mg tablet0.67USD tablet
Chlorothiazide 500 mg tablet0.36USD tablet
Chlorothiazide 250 mg tablet0.28USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point342.5-343Novello, F.C.; US. Patent 2,809,194; October 8,1957; assigned to Merck & Co.,Inc. Hinkley, D.F.; US. Patent 2,937,169; May 17,1960; assigned to Merck & Co., Inc.
water solubility266 mg/L (at 30 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP-0.24HANSCH,C ET AL. (1995)
logS-3.05ADME Research, USCD
Caco2 permeability-6.72ADME Research, USCD
pKa6.85MERCK INDEX (1996)
Predicted Properties
PropertyValueSource
Water Solubility0.398 mg/mLALOGPS
logP0.41ALOGPS
logP-0.44ChemAxon
logS-2.9ALOGPS
pKa (Strongest Acidic)9.1ChemAxon
pKa (Strongest Basic)1.15ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area118.69 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity62.51 m3·mol-1ChemAxon
Polarizability24.55 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (10.1 KB)
SpectraNot Available
References
Synthesis Reference

Eugene S. Barabas, “Water soluble complex of a poly (vinyl lactam) and chlorothiazide and process for producing same.” U.S. Patent US4713238, issued December, 1985.

US4713238
General ReferenceNot Available
External Links
ATC CodesC03AA04
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (72.7 KB)
Interactions
Drug Interactions
Drug
AcetohexamideThiazide Diuretics may diminish the therapeutic effect of Antidiabetic Agents.
AlfentanilAnalgesics (Opioid) may enhance the adverse/toxic effect of Diuretics.
AlfuzosinMay enhance the hypotensive effect of Antihypertensives.
AllopurinolThiazide Diuretics may enhance the potential for allergic or hypersensitivity reactions to Allopurinol. Thiazide Diuretics may increase the serum concentration of Allopurinol. Specifically, Thiazide Diuretics may increase the concentration of Oxypurinol, an active metabolite of Allopurinol.
AlogliptinThiazide Diuretics may diminish the therapeutic effect of Antidiabetic Agents.
AmifostineAntihypertensives may enhance the hypotensive effect of Amifostine.
BuprenorphineAnalgesics (Opioid) may enhance the adverse/toxic effect of Diuretics.
ButabarbitalMay enhance the orthostatic hypotensive effect of Thiazide Diuretics.
ButethalMay enhance the orthostatic hypotensive effect of Thiazide Diuretics.
ButorphanolAnalgesics (Opioid) may enhance the adverse/toxic effect of Diuretics.
CanagliflozinThiazide Diuretics may diminish the therapeutic effect of Antidiabetic Agents.
CarbamazepineThiazide Diuretics may enhance the adverse/toxic effect of CarBAMazepine. Specifically, there may be an increased risk for hyponatremia.
ChlorpropamideThiazide Diuretics may diminish the therapeutic effect of Antidiabetic Agents.
CodeineAnalgesics (Opioid) may enhance the adverse/toxic effect of Diuretics.
ColesevelamMay decrease the absorption of Thiazide Diuretics. The diuretic response is likewise decreased.
CyclophosphamideThiazide Diuretics may enhance the adverse/toxic effect of Cyclophosphamide. Specifically, granulocytopenia may be enhanced.
DiazoxideThiazide Diuretics may enhance the adverse/toxic effect of Diazoxide.
DihydrocodeineAnalgesics (Opioid) may enhance the adverse/toxic effect of Diuretics.
DofetilideThiazide Diuretics may enhance the QTc-prolonging effect of Dofetilide. Thiazide Diuretics may increase the serum concentration of Dofetilide.
DuloxetineHypotensive Agents may enhance the orthostatic hypotensive effect of DULoxetine.
FentanylAnalgesics (Opioid) may enhance the adverse/toxic effect of Diuretics.
GliclazideThiazide Diuretics may diminish the therapeutic effect of Antidiabetic Agents.
GlimepirideThiazide Diuretics may diminish the therapeutic effect of Antidiabetic Agents.
GliquidoneThiazide Diuretics may diminish the therapeutic effect of Antidiabetic Agents.
GlyburideThiazide Diuretics may diminish the therapeutic effect of Antidiabetic Agents.
HeptabarbitalMay enhance the orthostatic hypotensive effect of Thiazide Diuretics.
HexobarbitalMay enhance the orthostatic hypotensive effect of Thiazide Diuretics.
HydrocodoneAnalgesics (Opioid) may enhance the adverse/toxic effect of Diuretics.
HydromorphoneAnalgesics (Opioid) may enhance the adverse/toxic effect of Diuretics.
Insulin AspartThiazide Diuretics may diminish the therapeutic effect of Antidiabetic Agents.
Insulin DetemirThiazide Diuretics may diminish the therapeutic effect of Antidiabetic Agents.
Insulin GlargineThiazide Diuretics may diminish the therapeutic effect of Antidiabetic Agents.
Insulin GlulisineThiazide Diuretics may diminish the therapeutic effect of Antidiabetic Agents.
Insulin LisproThiazide Diuretics may diminish the therapeutic effect of Antidiabetic Agents.
Insulin RegularThiazide Diuretics may diminish the therapeutic effect of Antidiabetic Agents.
Insulin, isophaneThiazide Diuretics may diminish the therapeutic effect of Antidiabetic Agents.
LevorphanolAnalgesics (Opioid) may enhance the adverse/toxic effect of Diuretics.
LinagliptinThiazide Diuretics may diminish the therapeutic effect of Antidiabetic Agents.
LithiumThiazide Diuretics may decrease the excretion of Lithium.
MetforminThiazide Diuretics may diminish the therapeutic effect of Antidiabetic Agents.
MethadoneAnalgesics (Opioid) may enhance the adverse/toxic effect of Diuretics.
MethohexitalMay enhance the orthostatic hypotensive effect of Thiazide Diuretics.
MethylphenidateMay diminish the antihypertensive effect of Antihypertensives.
MorphineAnalgesics (Opioid) may enhance the adverse/toxic effect of Diuretics.
NalbuphineAnalgesics (Opioid) may enhance the adverse/toxic effect of Diuretics.
ObinutuzumabAntihypertensives may enhance the hypotensive effect of Obinutuzumab.
OxcarbazepineThiazide Diuretics may enhance the adverse/toxic effect of OXcarbazepine. Specifically, there may be an increased risk for hyponatremia.
OxycodoneAnalgesics (Opioid) may enhance the adverse/toxic effect of Diuretics.
OxymorphoneAnalgesics (Opioid) may enhance the adverse/toxic effect of Diuretics.
PentobarbitalMay enhance the orthostatic hypotensive effect of Thiazide Diuretics.
PentoxifyllineMay enhance the hypotensive effect of Antihypertensives.
PethidineAnalgesics (Opioid) may enhance the adverse/toxic effect of Diuretics.
PorfimerPhotosensitizing Agents may enhance the photosensitizing effect of Porfimer.
PrimidoneMay enhance the orthostatic hypotensive effect of Thiazide Diuretics.
RemifentanilAnalgesics (Opioid) may enhance the adverse/toxic effect of Diuretics.
RepaglinideThiazide Diuretics may diminish the therapeutic effect of Antidiabetic Agents.
RisperidoneHypotensive Agents may enhance the hypotensive effect of RisperiDONE.
RituximabAntihypertensives may enhance the hypotensive effect of RiTUXimab.
SaxagliptinThiazide Diuretics may diminish the therapeutic effect of Antidiabetic Agents.
SecobarbitalMay enhance the orthostatic hypotensive effect of Thiazide Diuretics.
SufentanilAnalgesics (Opioid) may enhance the adverse/toxic effect of Diuretics.
TadalafilMay enhance the antihypertensive effect of Antihypertensives.
TapentadolAnalgesics (Opioid) may enhance the adverse/toxic effect of Diuretics.
TolbutamideThiazide Diuretics may diminish the therapeutic effect of Antidiabetic Agents.
TopiramateThiazide Diuretics may enhance the hypokalemic effect of Topiramate. Thiazide Diuretics may increase the serum concentration of Topiramate.
ToremifeneThiazide Diuretics may enhance the hypercalcemic effect of Toremifene.
TramadolAnalgesics (Opioid) may enhance the adverse/toxic effect of Diuretics.
VardenafilMay enhance the antihypertensive effect of Antihypertensives.
VerteporfinPhotosensitizing Agents may enhance the photosensitizing effect of Verteporfin.
VildagliptinThiazide Diuretics may diminish the therapeutic effect of Antidiabetic Agents.
YohimbineMay diminish the antihypertensive effect of Antihypertensives.
Food InteractionsNot Available

Targets

1. Solute carrier family 12 member 3

Kind: protein

Organism: Human

Pharmacological action: yes

Actions: inhibitor

Components

Name UniProt ID Details
Solute carrier family 12 member 3 P55017 Details

References:

  1. Thakker RV: Molecular pathology of renal chloride channels in Dent’s disease and Bartter’s syndrome. Exp Nephrol. 2000 Nov-Dec;8(6):351-60. Pubmed
  2. Schmidt H, Kabesch M, Schwarz HP, Kiess W: Clinical, biochemical and molecular genetic data in five children with Gitelman’s syndrome. Horm Metab Res. 2001 Jun;33(6):354-7. Pubmed
  3. Wilson FH, Kahle KT, Sabath E, Lalioti MD, Rapson AK, Hoover RS, Hebert SC, Gamba G, Lifton RP: Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4. Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):680-4. Epub 2003 Jan 6. Pubmed
  4. Maki N, Komatsuda A, Wakui H, Ohtani H, Kigawa A, Aiba N, Hamai K, Motegi M, Yamaguchi A, Imai H, Sawada K: Four novel mutations in the thiazide-sensitive Na-Cl co-transporter gene in Japanese patients with Gitelman’s syndrome. Nephrol Dial Transplant. 2004 Jul;19(7):1761-6. Epub 2004 Apr 6. Pubmed
  5. Reinalter SC, Jeck N, Peters M, Seyberth HW: Pharmacotyping of hypokalaemic salt-losing tubular disorders. Acta Physiol Scand. 2004 Aug;181(4):513-21. Pubmed

2. Carbonic anhydrase 1

Kind: protein

Organism: Human

Pharmacological action: yes

Actions: inhibitor

Components

Name UniProt ID Details
Carbonic anhydrase 1 P00915 Details

References:

  1. Puscas I, Coltau M, Baican M, Domuta G, Hecht A: Vasodilatory effect of diuretics is dependent on inhibition of vascular smooth muscle carbonic anhydrase by a direct mechanism of action. Drugs Exp Clin Res. 1999;25(6):271-9. Pubmed
  2. Puscas I, Coltau M, Baican M, Pasca R, Domuta G: The inhibitory effect of diuretics on carbonic anhydrases. Res Commun Mol Pathol Pharmacol. 1999;105(3):213-36. Pubmed

3. Carbonic anhydrase 2

Kind: protein

Organism: Human

Pharmacological action: yes

Actions: inhibitor

Components

Name UniProt ID Details
Carbonic anhydrase 2 P00918 Details

References:

  1. Weiner ID, Verlander JW: Renal and hepatic expression of the ammonium transporter proteins, Rh B Glycoprotein and Rh C Glycoprotein. Acta Physiol Scand. 2003 Dec;179(4):331-8. Pubmed
  2. Puscas I, Coltau M, Baican M, Pasca R, Domuta G: The inhibitory effect of diuretics on carbonic anhydrases. Res Commun Mol Pathol Pharmacol. 1999;105(3):213-36. Pubmed
  3. Verlander JW, Miller RT, Frank AE, Royaux IE, Kim YH, Weiner ID: Localization of the ammonium transporter proteins RhBG and RhCG in mouse kidney. Am J Physiol Renal Physiol. 2003 Feb;284(2):F323-37. Epub 2002 Oct 8. Pubmed
  4. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. Pubmed

4. Carbonic anhydrase 4

Kind: protein

Organism: Human

Pharmacological action: yes

Actions: inhibitor

Components

Name UniProt ID Details
Carbonic anhydrase 4 P22748 Details

References:

  1. Puscas I, Coltau M, Baican M, Domuta G, Hecht A: Vasodilatory effect of diuretics is dependent on inhibition of vascular smooth muscle carbonic anhydrase by a direct mechanism of action. Drugs Exp Clin Res. 1999;25(6):271-9. Pubmed
  2. Puscas I, Coltau M, Baican M, Pasca R, Domuta G: The inhibitory effect of diuretics on carbonic anhydrases. Res Commun Mol Pathol Pharmacol. 1999;105(3):213-36. Pubmed

Transporters

1. Solute carrier family 22 member 6

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Solute carrier family 22 member 6 Q4U2R8 Details

References:

  1. Uwai Y, Saito H, Hashimoto Y, Inui KI: Interaction and transport of thiazide diuretics, loop diuretics, and acetazolamide via rat renal organic anion transporter rOAT1. J Pharmacol Exp Ther. 2000 Oct;295(1):261-5. Pubmed

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Drug created on June 13, 2005 07:24 / Updated on September 16, 2013 17:12