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Showing drug card for Oxtriphylline (DB01303)

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for All Approved Biotech Experimental Illicit Nutraceutical Small Molecule Withdrawn drugs

Version	2.5
Creation Date	2007-06-30 14:28:32
Update Date	2009-02-19 16:04:19
Primary Accession Number	DB01303
Secondary Accession Number	Not Available
Name	Oxtriphylline
Drug Type	Approved Small Molecule
Description	Oxtriphylline is a cough medicine derived from xanthine and similar to theophylline, that acts as a bronchodilator to open up airways in the lung. It antagonizes adenosine receptors and promotes relaxation of airway smooth muscles. It is also thought to inhibit phosphodiesterases leading to higher levels of cAMP and increased bronchodilation.
Synonyms	Choline theophylline
Brand Names	Choledyl Theocolin
Brand Mixtures	Not Available
Chemical IUPAC Name	1,3-dimethyl-2-oxopurin-6-olate; 2-hydroxyethyl-trimethylazanium
Chemical Formula	C12H21N5O3
Chemical Structure
CAS Registry Number	4499-40-5
InChI Identifier	InChI=1/C7H8N4O2.C5H14NO/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;1-6(2,3)4-5-7/h3,12H,1-2H3;7H,4-5H2,1-3H3/q;+1/p-1/fC7H7N4O2.C5H14NO/h12h;/q-1;m
InChI Key	SOELXOBIIIBLRJ-PGYFHCKPCE
KEGG Drug	D02017
KEGG Compound	Not Available
PubChem Compound	656652
PubChem Substance	7849079
ChEBI ID	Not Available
PharmGKB ID	Not Available
HET ID	Not Available
GenBank ID	Not Available
Drug ID Number [DIN]	Not Available
RxList Link	Not Available
PDRhealth Link	Not Available
Wikipedia Link	http://en.wikipedia.org/wiki/Oxtriphylline
FDA Label	Not Available
Material Safety Data Sheet (MSDS)	Not Available
Synthesis Reference	Not Available
Average Molecular Weight	283.3268
Monoisotopic Molecular Weight	283.1644
State	Solid
Melting Point	Not Available
Experimental Water Solubility	Not Available Source: PhysProp
Predicted Water Solubility	4.52e-01 mg/mL Calculated using ALOGPS
Experimental LogP/Hydrophobicity	Not Available Source: PhysProp
Predicted LogP	-0.47 Calculated using ALOGPS
Experimental LogS	Not Available
Predicted LogS	-2.80 Calculated using ALOGPS
Experimental Caco2 Permeability	Not Available
pKa/Isoelectric Point	Not Available
Mass Spectrum	Not Available
MOL File	Show | Download
SDF File	Show | Download
PDB File	Show | Download
2D Structure
3D Structure
Experimental PDB ID	Not Available
Isomeric SMILES	C[N+](C)(C)CCO.CN1C(=O)N(C)C2=NC=NC2=C1[O-]
Canonical SMILES	C[N+](C)(C)CCO.CN1C(=O)N(C)C2=NC=NC2=C1[O-]
Drug Category	Bronchodilator Agents
ATC Codes	R03DA02
AHFS Codes	86:16.00
Indication	Used to treat the symptoms of asthma, bronchitis, and emphysema.
Pharmacology	Oxtriphylline is a bronchodilator. Oxtriphylline works in several ways: it relaxes muscles in your lungs and chest to allow more air in, decreases the sensitivity of your lungs to allergens and other substances that cause inflammation, and increases the contractions of your diaphragm to draw more air into the lungs.
Mechanism of Action	Oxtriphylline is a choline salt of theophylline. Oxtriphylline relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels and reduces airway responsiveness to histamine, methacholine, adenosine, and allergen. Oxtriphylline competitively inhibits type III and type IV phosphodiesterase (PDE), the enzyme responsible for breaking down cyclic AMP in smooth muscle cells, possibly resulting in bronchodilation. Oxtriphylline also binds to the adenosine A2B receptor and blocks adenosine mediated bronchoconstriction.
Absorption	Not Available
Toxicity	Symptoms of toxicity include abdominal pain (continuing or severe), confusion or change in behavior, convulsions (seizures), dark or bloody vomit, diarrhea, dizziness or lightheadedness, fast and/or irregular heartbeat, nervousness or restlessness (continuing), and trembling (continuing).
Protein Binding	Not Available
Biotransformation	Not Available
Half Life	Not Available
Dosage Forms	Form Route Elixir Oral Syrup Oral Tablet Oral
Patient Information	Not Available
Contraindications	Not Available
Interactions	Not Available
Drug Interactions	Drug Interaction Aciclovir Aciclovir increases the effect and toxicity of theophylline Adenosine This xanthine decreases the effect of adenosine Amobarbital The barbiturate decreases the effect of theophylline Aprobarbital The barbiturate decreases the effect of theophylline Atracurium Theophylline decreases the effect of muscle relaxant Butabarbital The barbiturate decreases the effect of theophylline Butalbital The barbiturate decreases the effect of theophylline Butethal The barbiturate decreases the effect of theophylline Carbamazepine Carbamazepine increases or decreases the effect of theophylline Carteolol Antagonism of action and increased effect of theophylline Cimetidine Cimetidine increases the effect of theophylline Ciprofloxacin The quinolone increases the effect of theophylline Clarithromycin Clarithromycin increases the effect and toxicity of theophylline Dihydroquinidine barbiturate The barbiturate decreases the effect of theophylline Disulfiram Disulfiram increases the effect and toxicity of theophylline Doxacurium Theophylline decreases the effect of muscle relaxant Enoxacin The quinolone increases the effect of theophylline Erythromycin The macrolide increases the effect and toxicity of theophylline Ethinyl Estradiol The contraceptive increases the effect and toxicity of theophylline Ethotoin Decreased effect of both products Fluvoxamine Fluvoxamine increases the effect and toxicity of theophylline Fosphenytoin Decreased effect of both products Gallamine Triethiodide Theophylline decreases the effect of muscle relaxant Grepafloxacin The quinolone increases the effect of theophylline Halothane Increased risk of cardiac arrhythmia Heptabarbital The barbiturate decreases the effect of theophylline Hexobarbital The barbiturate decreases the effect of theophylline Interferon Alfa-2a, Recombinant Interferon increases the effect and toxicity of theophylline Interferon Alfa-2b, Recombinant Interferon increases the effect and toxicity of theophylline Interferon alfa-n1 Interferon increases the effect and toxicity of theophylline Isoniazid Isoniazid increases the effect and toxicity of theophylline Josamycin The macrolide increases the effect and toxicity of theophylline Lithium Theophylline decreases serum levels of lithium Mephenytoin Decreased effect of both products Mestranol The contraceptive increases the effect and toxicity of theophylline Methohexital The barbiturate decreases the effect of theophylline Methylphenobarbital The barbiturate decreases the effect of theophylline Metocurine Theophylline decreases the effect of muscle relaxant Mexiletine Mexiletine increases the effect and toxicity of theophylline Mivacurium Theophylline decreases the effect of muscle relaxant Nadolol Antagonism of action and increased effect of theophylline Norfloxacin The quinolone increases the effect of theophylline Pancuronium Theophylline decreases the effect of muscle relaxant Pefloxacin The quinolone increases the effect of theophylline Peginterferon alfa-2a Interferon increases the effect and toxicity of theophylline Peginterferon alfa-2b Interferon increases the effect and toxicity of theophylline Penbutolol Antagonism of action and increased effect of theophylline Pentobarbital The barbiturate decreases the effect of theophylline Pentoxifylline Pentoxifylline increases the effect and toxicity of theophylline Phenobarbital The barbiturate decreases the effect of theophylline Phenytoin Decreased effect of both products Pindolol Antagonism of action and increased effect of theophylline Primidone The barbiturate decreases the effect of theophylline Propafenone Propafenone increases the effect of theophylline Propranolol Antagonism of action and increased effect of theophylline Quinidine barbiturate The barbiturate decreases the effect of theophylline Rifampin Rifampin decreases the effect and toxicity of theophylline Ritonavir Ritonavir decreases the effect of theophylline Rofecoxib Rofecoxib increases the effect and toxicity of theophylline Secobarbital The barbiturate decreases the effect of theophylline Sotalol Antagonism of action and increased effect of theophylline St. John's Wort St. John's Wort decreases the effect of theophylline Tacrine Tacrine increases the effect and toxicity of theophylline Talbutal The barbiturate decreases the effect of theophylline Terbinafine Terbinafine increases the effect and toxicity of theophylline Thiabendazole Thiabendazole increases the effect and toxicity of theophylline Ticlopidine Ticlopidine increases the effect and toxicity of theophylline Timolol Antagonism of action and increased effect of theophylline Troleandomycin The macrolide increases the effect and toxicity of theophylline Tubocurarine Theophylline decreases the effect of muscle relaxant Vecuronium Theophylline decreases the effect of muscle relaxant Verapamil Verapamil increases the effect of theophylline Zileuton Zileuton increases the effect and toxicity of theophylline
Food Interactions	Avoid high doses of caffeine. Take with food to reduce irritation.
Pathways	Not Available
General References	Wikipedia
Organisms Affected	Humans and other mammals

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