DrugBank: Citric Acid (DB04272)

targets (69) transporters (1)

Identification

Name

Citric Acid

Accession Number

DB04272 (EXPT00922)

Type

small molecule

Groups

experimental

Description

A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability. [PubChem]

Structure

Download: MOL | SDF | SMILES | InChI
Display: 2D Structure | 3D Structure

Synonyms

Not Available

Salts

Not Available

Brand names

Not Available

Brand mixtures

Not Available

Categories

Anticoagulants
Chelating Agents

CAS number

77-92-9

Weight

Average: 192.1235
Monoisotopic: 192.02700261

Chemical Formula

C₆H₈O₇

InChI Key

InChIKey=KRKNYBCHXYNGOX-UHFFFAOYSA-N

InChI

InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

Plain Text

IUPAC Name

2-hydroxypropane-1,2,3-tricarboxylic acid

SMILES

OC(=O)CC(O)(CC(O)=O)C(O)=O

Plain Text

Mass Spec

Not Available

Taxonomy

Kingdom

Not Available

Classes

Not Available

Substructures

Not Available

Pharmacology

Indication

Not Available

Pharmacodynamics

Not Available

Mechanism of action

Not Available

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Not Available

Route of elimination

Not Available

Half life

Not Available

Clearance

Not Available

Toxicity

Not Available

Affected organisms

Not Available

Pathways

Not Available

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage forms

Not Available

Prices

Not Available

Patents

Not Available

Properties

State

solid

Experimental Properties

Property	Value	Source
melting point	153 °C	PhysProp
water solubility	5.92E+005 mg/L (at 20 °C)	MERCK INDEX (1989)
logP	-1.64	AVDEEF,A (1997)
logS	0.51	ADME Research, USCD
pKa	2.79	SERJEANT,EP & DEMPSEY,B (1979)

Predicted Properties

Property	Value	Source
water solubility	1.06e+02 g/l	ALOGPS
logP	-1.3	ALOGPS
logP	-1.3	ChemAxon
logS	-0.26	ALOGPS
pKa (strongest acidic)	3.05	ChemAxon
pKa (strongest basic)	-4.2	ChemAxon
physiological charge	-3	ChemAxon
hydrogen acceptor count	7	ChemAxon
hydrogen donor count	4	ChemAxon
polar surface area	132.13	ChemAxon
rotatable bond count	5	ChemAxon
refractivity	35.62	ChemAxon
polarizability	15.54	ChemAxon

References

Synthesis Reference

Not Available

General Reference

Not Available

External Links

Resource	Link
KEGG Drug	D00037
KEGG Compound	C00158
BindingDB	14672
ChEBI	30769
ChEMBL	30769
PharmGKB	PA449021
IUPHAR	2478
Guide to Pharmacology	2478
HET	CIT

ATC Codes

A09AB04

AHFS Codes

Not Available

PDB Entries

1HTO

FDA label

Not Available

MSDS

Not Available

Interactions

Drug Interactions

Drug	Interaction
Eltrombopag	Levels of eltrombopag are decreased due to GI inhibition. Separate administration by at least 4 hours.
Lithium	The urine alkalizer decreases the effect of lithium

Food Interactions

Not Available

Targets
1. KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase Pharmacological action: unknown 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate Organism class: bacterial UniProt ID: P0A955 Gene: eda Protein Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 2. Molybdopterin-guanine dinucleotide biosynthesis protein A Pharmacological action: unknown Links a guanosine 5'-phosphate to molydopterin (MPT) forming molybdopterin guanine dinucleotide (MGD) Organism class: bacterial UniProt ID: P32173 Gene: mobA Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 3. Fumarate hydratase class II Pharmacological action: unknown (S)-malate = fumarate + H(2)O Organism class: bacterial UniProt ID: P05042 Gene: fumC Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 4. 6-phosphogluconolactonase Pharmacological action: unknown Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate Organism class: bacterial UniProt ID: Q9X0N8 Gene: pgl Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 5. Oxygen-insensitive NAD(P)H nitroreductase Pharmacological action: unknown Reduction of a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferred. Capable of reducing nitrofurazone, quinones and the anti-tumor agent CB1954 (5- (aziridin-1-yl)-2,4-dinitrobenzamide). The reduction of CB1954 results in the generation of cytotoxic species Organism class: bacterial UniProt ID: P38489 Gene: nfnB Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 6. Pol polyprotein Pharmacological action: unknown During replicative cycle of retroviruses, the reverse- transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase Organism class: viral UniProt ID: Q04095 Gene: gag-pro-pol Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 7. L-amino-acid oxidase Pharmacological action: unknown Organism class: human UniProt ID: Q96RQ9 Gene: IL4I1 SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 8. Macrophage migration inhibitory factor Pharmacological action: unknown The expression of MIF at sites of inflammation suggest a role for the mediator in regulating the function of macrophage in host defense. Also acts as a phenylpyruvate tautomerase Organism class: human UniProt ID: P14174 Gene: MIF Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 9. Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 Pharmacological action: unknown Organism class: human UniProt ID: Q9GZU7 Gene: CTDSP1 SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 10. 1-deoxy-D-xylulose 5-phosphate reductoisomerase Pharmacological action: unknown Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) Organism class: bacterial UniProt ID: P45568 Gene: dxr Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 11. Tryptophan synthase alpha chain Pharmacological action: unknown The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate Organism class: bacterial UniProt ID: P16608 Gene: trpA Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 12. Sialidase Pharmacological action: unknown To release sialic acids for use as carbon and energy sources for this non-pathogenic bacterium while in pathogenic microorganisms, sialidases have been suggested to be pathogenic factors Organism class: bacterial UniProt ID: Q02834 Gene: nedA Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 13. RNASE4 protein Pharmacological action: unknown Organism class: human UniProt ID: Q53X86 Gene: RNASE4 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 14. Cytochrome c peroxidase Pharmacological action: unknown Organism class: bacterial UniProt ID: P83787 Protein Sequence: FASTA 15. Hepatocyte growth factor-regulated tyrosine kinase substrate Pharmacological action: unknown Organism class: human UniProt ID: O14964 Gene: HGS SNPs: SNPJam Report References: Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 16. Invasin Pharmacological action: unknown Invasin is a protein that allows enteric bacteria to penetrate cultured mammalian cells. The entry of invasin in the cell is mediated by binding several beta-1 chain integrins Organism class: bacterial UniProt ID: P11922 Gene: YPTB1668 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 17. Intron-associated endonuclease 1 Pharmacological action: unknown This endonuclease is specific to the thymidylate synthase (td) gene splice junction and is involved in intron homing Organism class: viral UniProt ID: P13299 Gene: ITEVIR Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 18. Short tail fiber protein Pharmacological action: unknown Structural component of the short tail fiber (baseplate) Organism class: viral UniProt ID: P10930 Gene: 12 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 19. Malate dehydrogenase, mitochondrial Pharmacological action: unknown Organism class: human UniProt ID: P40926 Gene: MDH2 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 20. N5-carboxyaminoimidazole ribonucleotide mutase Pharmacological action: unknown Organism class: bacterial UniProt ID: Q2QJL3 Gene: purE Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 21. 50S ribosomal protein L4 Pharmacological action: unknown Forms part of the polypeptide exit tunnel (By similarity) Organism class: bacterial UniProt ID: P38516 Gene: rplD Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 22. Carboxypeptidase B Pharmacological action: unknown Preferential release of a C-terminal lysine or arginine amino acid Organism class: human UniProt ID: P15086 Gene: CPB1 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 23. Medium-chain-fatty-acid--CoA ligase Pharmacological action: unknown Organism class: bacterial UniProt ID: Q6L8F0 Protein Sequence: FASTA Gene Sequence: FASTA 24. Hexon protein Pharmacological action: unknown This protein is one of the structural proteins in the viral coat and is synthesized during late infection Organism class: viral UniProt ID: P03277 Gene: PII Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 25. Riboflavin kinase/FMN adenylyltransferase Pharmacological action: unknown Organism class: bacterial UniProt ID: Q9WZW1 Gene: TM_0857 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 26. Beta-fructosidase Pharmacological action: unknown Hydrolysis of sucrose, raffinose, inulin and levan. Specific for the fructose moiety and the beta-anomeric configuration of the glycosidic linkages of its substrates. The enzyme released fructose from sucrose and raffinose, and the fructose polymer inulin is hydrolyzed quantitatively in an exo- type fashion Organism class: bacterial UniProt ID: O33833 Gene: bfrA Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 27. Regulator of transcription; stringent starvation protein A Pharmacological action: unknown Organism class: bacterial UniProt ID: Q7CL96 Gene: sspA Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 28. Citrate synthase Pharmacological action: unknown Organism class: bacterial UniProt ID: Q9LCX9 Gene: cit Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 29. RNA 3'-terminal phosphate cyclase Pharmacological action: unknown Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps:(A) adenylation of the enzyme by ATP; (B) the enzyme acts on RNA-N3'P to produce RNA-N3'PP5'A; (C) a non catalytic nucleophilic attack by the adjacent 2'hydroxyl on the phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing Organism class: bacterial UniProt ID: P46849 Gene: rtcA Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 30. U6 snRNA-associated Sm-like protein LSm6 Pharmacological action: unknown Organism class: human UniProt ID: P62312 Gene: LSM6 SNPs: SNPJam Report References: Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 31. Pleckstrin homology domain-containing family A member 1 Pharmacological action: unknown Binds specifically to phosphatidylinositol-3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane Organism class: human UniProt ID: Q9HB21 Gene: PLEKHA1 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 32. Iron(III)-binding periplasmic protein Pharmacological action: unknown Part of the ABC transporter complex fbpABC (TC 3.A.1.10.1) involved in Fe(3+) ions import. This protein specifically binds Fe(3+) and is involved in its transmembrane transport (By similarity) Organism class: bacterial UniProt ID: P21408 Gene: fbpA Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 33. Cell division protein FtsY Pharmacological action: unknown Organism class: bacterial UniProt ID: Q9WZ40 Gene: TM_0570 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 34. Nicotinate-nucleotide adenylyltransferase Pharmacological action: unknown Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) Organism class: bacterial UniProt ID: P0A753 Gene: nadD Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 35. N utilization substance protein B homolog Pharmacological action: unknown Involved in the transcription termination process (By similarity) Organism class: bacterial UniProt ID: Q9X286 Gene: nusB Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 36. Complement component C8 gamma chain Pharmacological action: unknown C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol Organism class: human UniProt ID: P07360 Gene: C8G Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 37. Ribonucleoside-diphosphate reductase subunit beta Pharmacological action: unknown Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Organism class: bacterial UniProt ID: Q9CBQ2 Gene: nrdF Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 38. Glutamine synthetase 1 Pharmacological action: unknown ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine Organism class: bacterial UniProt ID: P0A590 Gene: glnA1 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 39. Citrate synthase Pharmacological action: unknown Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA Organism class: bacterial UniProt ID: O34002 Gene: gltA Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 40. Transferase Pharmacological action: unknown Organism class: bacterial UniProt ID: Q7SIC5 Protein Sequence: FASTA 41. Prostaglandin F synthase Pharmacological action: unknown Organism class: parasitic UniProt ID: Q9GV41 Gene: Tb11.02.2310 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 42. Cell division protein ftsZ Pharmacological action: unknown This protein is essential to the cell-division process. It seems to assemble into a dynamic ring on the inner surface of the cytoplasmic membrane at the place where division will occur, and the formation of the ring is the signal for septation to begin. Binds to and hydrolyzes GTP Organism class: bacterial UniProt ID: P64170 Gene: ftsZ Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 43. Adenine phosphoribosyltransferase Pharmacological action: unknown Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis Organism class: human UniProt ID: P07741 Gene: APRT Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 44. Angiogenin Pharmacological action: unknown May function as a tRNA-specific ribonuclease that binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus, thereby promoting the endothelial invasiveness necessary for blood vessel formation. Angiogenin induces vascularization of normal and malignant tissues. Abolishes protein synthesis by specifically hydrolyzing cellular tRNAs Organism class: human UniProt ID: P03950 Gene: ANG Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 45. Glucose-1-phosphate thymidylyltransferase Pharmacological action: unknown Organism class: bacterial UniProt ID: Q9HU22 Gene: rmlA Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 46. Beta-lactamase II Pharmacological action: unknown Can hydrolyze carbapenem compounds Organism class: bacterial UniProt ID: P04190 Gene: blm Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 47. Glyoxalase family protein Pharmacological action: unknown Organism class: bacterial UniProt ID: Q81F54 Gene: BC_1747 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 48. Uridine-cytidine kinase 2 Pharmacological action: unknown Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4- thiouridine, 5-bromouridine, 4-N-acetylcytidine, 4-N- benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5- methylcytidine, and 4-N-anisoylcytidine Organism class: human UniProt ID: Q9BZX2 Gene: UCK2 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 49. Tumor necrosis factor ligand superfamily member 13B Pharmacological action: unknown Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response Organism class: human UniProt ID: Q9Y275 Gene: TNFSF13B Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 50. UPF0124 protein yfiH Pharmacological action: unknown Organism class: bacterial UniProt ID: P33644 Gene: yfiH Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 51. Betaine--homocysteine S-methyltransferase 1 Pharmacological action: unknown Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline Organism class: human UniProt ID: Q93088 Gene: BHMT Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 52. Ribose-5-phosphate isomerase A Pharmacological action: unknown D-ribose 5-phosphate = D-ribulose 5-phosphate Organism class: bacterial UniProt ID: P44725 Gene: rpiA Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 53. Tryptophanyl-tRNA synthetase Pharmacological action: unknown ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp) Organism class: bacterial UniProt ID: P00953 Gene: trpS Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 54. GMP synthase [glutamine-hydrolyzing] Pharmacological action: unknown Catalyzes the synthesis of GMP from XMP Organism class: bacterial UniProt ID: P04079 Gene: guaA Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 55. Aldose reductase Pharmacological action: unknown Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies Organism class: human UniProt ID: P15121 Gene: AKR1B1 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 56. Inosine triphosphate pyrophosphatase Pharmacological action: unknown Organism class: human UniProt ID: Q9BY32 Gene: ITPA SNPs: SNPJam Report References: Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 57. Citrate synthase, mitochondrial Pharmacological action: unknown Organism class: human UniProt ID: O75390 Gene: CS SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 58. Lysozyme Pharmacological action: unknown Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity (By similarity) Organism class: viral UniProt ID: Q37875 Gene: 17 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 59. Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 Pharmacological action: unknown Transfers a sulfuryl group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate Organism class: human UniProt ID: Q9Y663 Gene: HS3ST3A1 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 60. Glycerol uptake operon antiterminator-related protein Pharmacological action: unknown Organism class: bacterial UniProt ID: Q9X1F0 Gene: TM_1436 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 61. cGMP-specific 3',5'-cyclic phosphodiesterase Pharmacological action: unknown Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'- GMP Organism class: human UniProt ID: O76074 Gene: PDE5A Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 62. 3-carboxy-cis,cis-muconate cycloisomerase Pharmacological action: unknown Catalyzes an anti cycloisomerization Organism class: bacterial UniProt ID: P32427 Gene: pcaB Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 63. Proto-oncogene tyrosine-protein kinase Src Pharmacological action: unknown Organism class: human UniProt ID: P12931 Gene: SRC Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 64. Pyruvate decarboxylase Pharmacological action: unknown A 2-oxo acid = an aldehyde + CO(2) Organism class: bacterial UniProt ID: P06672 Gene: pdc Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 65. Ribonuclease pancreatic Pharmacological action: unknown Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA Organism class: human UniProt ID: P07998 Gene: RNASE1 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 66. Isocitrate dehydrogenase [NADP] Pharmacological action: unknown Isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH Organism class: bacterial UniProt ID: P39126 Gene: icd Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 67. Glycine N-methyltransferase Pharmacological action: unknown Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine Organism class: human UniProt ID: Q14749 Gene: GNMT Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 68. Eosinophil cationic protein Pharmacological action: unknown Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity Organism class: human UniProt ID: P12724 Gene: RNASE3 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 69. Beta-lactamase Pharmacological action: unknown A beta-lactam + H(2)O = a substituted beta- amino acid Organism class: bacterial UniProt ID: P00808 Gene: penP Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

Targets

1. KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase

Pharmacological action: unknown

4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate

Organism class: bacterial
UniProt ID: P0A955 Link_out

Gene: eda
Protein Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

2. Molybdopterin-guanine dinucleotide biosynthesis protein A

Pharmacological action: unknown

Links a guanosine 5'-phosphate to molydopterin (MPT) forming molybdopterin guanine dinucleotide (MGD)

Organism class: bacterial
UniProt ID: P32173 Link_out

Gene: mobA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

3. Fumarate hydratase class II

Pharmacological action: unknown

(S)-malate = fumarate + H(2)O

Organism class: bacterial
UniProt ID: P05042 Link_out

Gene: fumC
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

4. 6-phosphogluconolactonase

Pharmacological action: unknown

Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate

Organism class: bacterial
UniProt ID: Q9X0N8 Link_out

Gene: pgl
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

5. Oxygen-insensitive NAD(P)H nitroreductase

Pharmacological action: unknown

Reduction of a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferred. Capable of reducing nitrofurazone, quinones and the anti-tumor agent CB1954 (5- (aziridin-1-yl)-2,4-dinitrobenzamide). The reduction of CB1954 results in the generation of cytotoxic species

Organism class: bacterial
UniProt ID: P38489 Link_out

Gene: nfnB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

6. Pol polyprotein

Pharmacological action: unknown

During replicative cycle of retroviruses, the reverse- transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase

Organism class: viral
UniProt ID: Q04095 Link_out

Gene: gag-pro-pol
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

7. L-amino-acid oxidase

Pharmacological action: unknown
Organism class: human
UniProt ID: Q96RQ9 Link_out

Gene: IL4I1
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

8. Macrophage migration inhibitory factor

Pharmacological action: unknown

The expression of MIF at sites of inflammation suggest a role for the mediator in regulating the function of macrophage in host defense. Also acts as a phenylpyruvate tautomerase

Organism class: human
UniProt ID: P14174 Link_out

Gene: MIF

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

9. Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

Pharmacological action: unknown
Organism class: human
UniProt ID: Q9GZU7 Link_out

Gene: CTDSP1
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

10. 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Pharmacological action: unknown

Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

Organism class: bacterial
UniProt ID: P45568 Link_out

Gene: dxr
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

11. Tryptophan synthase alpha chain

Pharmacological action: unknown

The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate

Organism class: bacterial
UniProt ID: P16608 Link_out

Gene: trpA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

12. Sialidase

Pharmacological action: unknown

To release sialic acids for use as carbon and energy sources for this non-pathogenic bacterium while in pathogenic microorganisms, sialidases have been suggested to be pathogenic factors

Organism class: bacterial
UniProt ID: Q02834 Link_out

Gene: nedA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

13. RNASE4 protein

Pharmacological action: unknown
Organism class: human
UniProt ID: Q53X86 Link_out

Gene: RNASE4
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

14. Cytochrome c peroxidase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: P83787 Link_out

Protein Sequence: FASTA

15. Hepatocyte growth factor-regulated tyrosine kinase substrate

Pharmacological action: unknown
Organism class: human
UniProt ID: O14964 Link_out

Gene: HGS
SNPs: SNPJam Report Link_out

References:

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

16. Invasin

Pharmacological action: unknown

Invasin is a protein that allows enteric bacteria to penetrate cultured mammalian cells. The entry of invasin in the cell is mediated by binding several beta-1 chain integrins

Organism class: bacterial
UniProt ID: P11922 Link_out

Gene: YPTB1668
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

17. Intron-associated endonuclease 1

Pharmacological action: unknown

This endonuclease is specific to the thymidylate synthase (td) gene splice junction and is involved in intron homing

Organism class: viral
UniProt ID: P13299 Link_out

Gene: ITEVIR
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

18. Short tail fiber protein

Pharmacological action: unknown

Structural component of the short tail fiber (baseplate)

Organism class: viral
UniProt ID: P10930 Link_out

Gene: 12
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

19. Malate dehydrogenase, mitochondrial

Pharmacological action: unknown
Organism class: human
UniProt ID: P40926 Link_out

Gene: MDH2 Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

20. N5-carboxyaminoimidazole ribonucleotide mutase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q2QJL3 Link_out

Gene: purE
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

21. 50S ribosomal protein L4

Pharmacological action: unknown

Forms part of the polypeptide exit tunnel (By similarity)

Organism class: bacterial
UniProt ID: P38516 Link_out

Gene: rplD
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

22. Carboxypeptidase B

Pharmacological action: unknown

Preferential release of a C-terminal lysine or arginine amino acid

Organism class: human
UniProt ID: P15086 Link_out

Gene: CPB1
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

23. Medium-chain-fatty-acid--CoA ligase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q6L8F0 Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA

24. Hexon protein

Pharmacological action: unknown

This protein is one of the structural proteins in the viral coat and is synthesized during late infection

Organism class: viral
UniProt ID: P03277 Link_out

Gene: PII
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

25. Riboflavin kinase/FMN adenylyltransferase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q9WZW1 Link_out

Gene: TM_0857
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

26. Beta-fructosidase

Pharmacological action: unknown

Hydrolysis of sucrose, raffinose, inulin and levan. Specific for the fructose moiety and the beta-anomeric configuration of the glycosidic linkages of its substrates. The enzyme released fructose from sucrose and raffinose, and the fructose polymer inulin is hydrolyzed quantitatively in an exo- type fashion

Organism class: bacterial
UniProt ID: O33833 Link_out

Gene: bfrA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

27. Regulator of transcription; stringent starvation protein A

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q7CL96 Link_out

Gene: sspA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

28. Citrate synthase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q9LCX9 Link_out

Gene: cit
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

29. RNA 3'-terminal phosphate cyclase

Pharmacological action: unknown

Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps:(A) adenylation of the enzyme by ATP; (B) the enzyme acts on RNA-N3'P to produce RNA-N3'PP5'A; (C) a non catalytic nucleophilic attack by the adjacent 2'hydroxyl on the phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing

Organism class: bacterial
UniProt ID: P46849 Link_out

Gene: rtcA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

30. U6 snRNA-associated Sm-like protein LSm6

Pharmacological action: unknown
Organism class: human
UniProt ID: P62312 Link_out

Gene: LSM6
SNPs: SNPJam Report Link_out

References:

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

31. Pleckstrin homology domain-containing family A member 1

Pharmacological action: unknown

Binds specifically to phosphatidylinositol-3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane

Organism class: human
UniProt ID: Q9HB21 Link_out

Gene: PLEKHA1
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

32. Iron(III)-binding periplasmic protein

Pharmacological action: unknown

Part of the ABC transporter complex fbpABC (TC 3.A.1.10.1) involved in Fe(3+) ions import. This protein specifically binds Fe(3+) and is involved in its transmembrane transport (By similarity)

Organism class: bacterial
UniProt ID: P21408 Link_out

Gene: fbpA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

33. Cell division protein FtsY

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q9WZ40 Link_out

Gene: TM_0570
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

34. Nicotinate-nucleotide adenylyltransferase

Pharmacological action: unknown

Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)

Organism class: bacterial
UniProt ID: P0A753 Link_out

Gene: nadD
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

35. N utilization substance protein B homolog

Pharmacological action: unknown

Involved in the transcription termination process (By similarity)

Organism class: bacterial
UniProt ID: Q9X286 Link_out

Gene: nusB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

36. Complement component C8 gamma chain

Pharmacological action: unknown

C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol

Organism class: human
UniProt ID: P07360 Link_out

Gene: C8G
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

37. Ribonucleoside-diphosphate reductase subunit beta

Pharmacological action: unknown

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)

Organism class: bacterial
UniProt ID: Q9CBQ2 Link_out

Gene: nrdF
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

38. Glutamine synthetase 1

Pharmacological action: unknown

ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine

Organism class: bacterial
UniProt ID: P0A590 Link_out

Gene: glnA1
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

39. Citrate synthase

Pharmacological action: unknown

Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA

Organism class: bacterial
UniProt ID: O34002 Link_out

Gene: gltA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

40. Transferase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q7SIC5 Link_out

Protein Sequence: FASTA

41. Prostaglandin F synthase

Pharmacological action: unknown
Organism class: parasitic
UniProt ID: Q9GV41 Link_out

Gene: Tb11.02.2310
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

42. Cell division protein ftsZ

Pharmacological action: unknown

This protein is essential to the cell-division process. It seems to assemble into a dynamic ring on the inner surface of the cytoplasmic membrane at the place where division will occur, and the formation of the ring is the signal for septation to begin. Binds to and hydrolyzes GTP

Organism class: bacterial
UniProt ID: P64170 Link_out

Gene: ftsZ
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

43. Adenine phosphoribosyltransferase

Pharmacological action: unknown

Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

Organism class: human
UniProt ID: P07741 Link_out

Gene: APRT Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

44. Angiogenin

Pharmacological action: unknown

May function as a tRNA-specific ribonuclease that binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus, thereby promoting the endothelial invasiveness necessary for blood vessel formation. Angiogenin induces vascularization of normal and malignant tissues. Abolishes protein synthesis by specifically hydrolyzing cellular tRNAs

Organism class: human
UniProt ID: P03950 Link_out

Gene: ANG

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

45. Glucose-1-phosphate thymidylyltransferase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q9HU22 Link_out

Gene: rmlA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

46. Beta-lactamase II

Pharmacological action: unknown

Can hydrolyze carbapenem compounds

Organism class: bacterial
UniProt ID: P04190 Link_out

Gene: blm
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

47. Glyoxalase family protein

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q81F54 Link_out

Gene: BC_1747
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

48. Uridine-cytidine kinase 2

Pharmacological action: unknown

Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4- thiouridine, 5-bromouridine, 4-N-acetylcytidine, 4-N- benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5- methylcytidine, and 4-N-anisoylcytidine

Organism class: human
UniProt ID: Q9BZX2 Link_out

Gene: UCK2 Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

49. Tumor necrosis factor ligand superfamily member 13B

Pharmacological action: unknown

Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response

Organism class: human
UniProt ID: Q9Y275 Link_out

Gene: TNFSF13B Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

50. UPF0124 protein yfiH

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: P33644 Link_out

Gene: yfiH
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

51. Betaine--homocysteine S-methyltransferase 1

Pharmacological action: unknown

Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline

Organism class: human
UniProt ID: Q93088 Link_out

Gene: BHMT Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

52. Ribose-5-phosphate isomerase A

Pharmacological action: unknown

D-ribose 5-phosphate = D-ribulose 5-phosphate

Organism class: bacterial
UniProt ID: P44725 Link_out

Gene: rpiA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

53. Tryptophanyl-tRNA synthetase

Pharmacological action: unknown

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp)

Organism class: bacterial
UniProt ID: P00953 Link_out

Gene: trpS
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

54. GMP synthase [glutamine-hydrolyzing]

Pharmacological action: unknown

Catalyzes the synthesis of GMP from XMP

Organism class: bacterial
UniProt ID: P04079 Link_out

Gene: guaA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

55. Aldose reductase

Pharmacological action: unknown

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies

Organism class: human
UniProt ID: P15121 Link_out

Gene: AKR1B1 Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

56. Inosine triphosphate pyrophosphatase

Pharmacological action: unknown
Organism class: human
UniProt ID: Q9BY32 Link_out

Gene: ITPA
SNPs: SNPJam Report Link_out

References:

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

57. Citrate synthase, mitochondrial

Pharmacological action: unknown
Organism class: human
UniProt ID: O75390 Link_out

Gene: CS
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

58. Lysozyme

Pharmacological action: unknown

Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity (By similarity)

Organism class: viral
UniProt ID: Q37875 Link_out

Gene: 17
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

59. Heparan sulfate glucosamine 3-O-sulfotransferase 3A1

Pharmacological action: unknown

Transfers a sulfuryl group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate

Organism class: human
UniProt ID: Q9Y663 Link_out

Gene: HS3ST3A1 Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

60. Glycerol uptake operon antiterminator-related protein

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q9X1F0 Link_out

Gene: TM_1436
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

61. cGMP-specific 3',5'-cyclic phosphodiesterase

Pharmacological action: unknown

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'- GMP

Organism class: human
UniProt ID: O76074 Link_out

Gene: PDE5A Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

62. 3-carboxy-cis,cis-muconate cycloisomerase

Pharmacological action: unknown

Catalyzes an anti cycloisomerization

Organism class: bacterial
UniProt ID: P32427 Link_out

Gene: pcaB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

63. Proto-oncogene tyrosine-protein kinase Src

Pharmacological action: unknown
Organism class: human
UniProt ID: P12931 Link_out

Gene: SRC

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

64. Pyruvate decarboxylase

Pharmacological action: unknown

A 2-oxo acid = an aldehyde + CO(2)

Organism class: bacterial
UniProt ID: P06672 Link_out

Gene: pdc
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

65. Ribonuclease pancreatic

Pharmacological action: unknown

Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA

Organism class: human
UniProt ID: P07998 Link_out

Gene: RNASE1
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

66. Isocitrate dehydrogenase [NADP]

Pharmacological action: unknown

Isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH

Organism class: bacterial
UniProt ID: P39126 Link_out

Gene: icd
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

67. Glycine N-methyltransferase

Pharmacological action: unknown

Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine

Organism class: human
UniProt ID: Q14749 Link_out

Gene: GNMT Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

68. Eosinophil cationic protein

Pharmacological action: unknown

Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity

Organism class: human
UniProt ID: P12724 Link_out

Gene: RNASE3 Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

69. Beta-lactamase

Pharmacological action: unknown

A beta-lactam + H(2)O = a substituted beta- amino acid

Organism class: bacterial
UniProt ID: P00808 Link_out

Gene: penP
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

Transporters
1. Solute carrier organic anion transporter family member 2B1 Actions: inhibitor Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost UniProt ID: O94956 Gene: SLCO2B1 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Kobayashi D, Nozawa T, Imai K, Nezu J, Tsuji A, Tamai I: Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane. J Pharmacol Exp Ther. 2003 Aug;306(2):703-8. Epub 2003 Apr 30. Pubmed

Transporters

1. Solute carrier organic anion transporter family member 2B1

Actions: inhibitor

Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost

UniProt ID: O94956 Link_out

Gene: SLCO2B1 Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Kobayashi D, Nozawa T, Imai K, Nezu J, Tsuji A, Tamai I: Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane. J Pharmacol Exp Ther. 2003 Aug;306(2):703-8. Epub 2003 Apr 30. Pubmed

Comments

Drug created on June 13, 2005 07:24 / Updated on February 08, 2013 16:23