DrugBank: Isopropyl Alcohol (DB02325)

targets (31)

Identification

Name

Isopropyl Alcohol

Accession Number

DB02325 (DB04402, EXPT01912)

Type

small molecule

Groups

experimental

Description

An isomer of 1-propanol. It is a colorless liquid having disinfectant properties. It is used in the manufacture of acetone and its derivatives and as a solvent. Topically, it is used as an antiseptic. [PubChem]

Structure

Download: MOL | SDF | SMILES | InChI
Display: 2D Structure | 3D Structure

Synonyms

Not Available

Brand names

Not Available

Brand name mixtures

Not Available

Categories

Solvents

CAS number

67-63-0

Weight

Average: 60.095
Monoisotopic: 60.057514878

Chemical Formula

C₃H₈O

InChI Key

InChIKey=KFZMGEQAYNKOFK-UHFFFAOYSA-N

InChI

InChI=1S/C3H8O/c1-3(2)4/h3-4H,1-2H3

Plain Text

IUPAC Name

propan-2-ol

SMILES

CC(C)O

Plain Text

Mass Spec

Not Available

Taxonomy

Kingdom

Not Available

Classes

Not Available

Substructures

Not Available

Pharmacology

Indication

Not Available

Pharmacodynamics

Not Available

Mechanism of action

Not Available

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Route of elimination

Not Available

Half life

Not Available

Clearance

Not Available

Toxicity

Not Available

Affected organisms

Not Available

Pathways

Not Available

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Dosage forms

Not Available

Prices

Not Available

Patents

Not Available

Properties

State

solid

Melting point

-89.5 oC

Experimental Properties

Property	Value	Source
water solubility	1000 mg/mL at 25 oC [RIDDICK,JA et al. (1986)]	PhysProp
logP	0.05 [HANSCH,C ET AL. (1995)]	PhysProp

Predicted Properties

Property	Value	Source
water solubility	3.78e+02 g/l	ALOGPS
logP	0.04	ALOGPS
logP	0.25	ChemAxon Molconvert
logS	0.80	ALOGPS
pKa		ChemAxon Molconvert
hydrogen acceptor count	1	ChemAxon Molconvert
hydrogen donor count	1	ChemAxon Molconvert
polar surface area	20.23	ChemAxon Molconvert
rotatable bond count	0	ChemAxon Molconvert
refractivity	17.43	ChemAxon Molconvert
polarizability	7.14	ChemAxon Molconvert

References

Synthesis Reference

Not Available

General Reference

Not Available

External Links

Resource	Link
KEGG Drug	D00137
KEGG Compound	C01845
PubChem Compound	3776
PubChem Substance	46508136
ChemSpider	3644
ChEBI	17824
ChEMBL	17824
PharmGKB	PA450117
HET	IPA
Drug Product Database	167649

ATC Codes

Not Available

AHFS Codes

Not Available

PDB Entries

1FB1
1M8A

FDA label

Not Available

MSDS

Not Available

Interactions

Drug Interactions

Drug	Interaction

Food Interactions

Not Available

Targets
1. Hypothetical protein Pharmacological action: unknown Organism class: bacterial UniProt ID: Q9I1L3 Gene: kguE Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 2. mRNA-capping enzyme Pharmacological action: unknown Organism class: human UniProt ID: O60942 Gene: RNGTT SNPs: SNPJam Report References: Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 3. FMN-dependent NADH-azoreductase Pharmacological action: unknown Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity. The enzyme can reduce ethyl red and methyl red, but is not able to convert sulfonated azo dyes Organism class: bacterial UniProt ID: P41407 Gene: azoR Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 4. Transcription antitermination protein nusG Pharmacological action: unknown Influences transcription termination and antitermination. Acts as a component of the transcription complex, and interacts with the termination factor rho and RNA polymerase (By similarity) Organism class: bacterial UniProt ID: O67757 Gene: nusG Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 5. 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase Pharmacological action: unknown Organism class: human UniProt ID: Q9BV57 Gene: ADI1 SNPs: SNPJam Report References: Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 6. GTP cyclohydrolase I Pharmacological action: unknown Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown Organism class: human UniProt ID: P30793 Gene: GCH1 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 7. Growth/differentiation factor 5 Pharmacological action: unknown Could be involved in bone formation Organism class: human UniProt ID: P43026 Gene: GDF5 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 8. Subtilisin BPN' Pharmacological action: unknown Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides. Has a high substrate specificity to fibrin Organism class: bacterial UniProt ID: P00782 Gene: apr Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 9. Ig kappa chain V-IV region Len Pharmacological action: unknown Organism class: human UniProt ID: P01625 Protein Sequence: FASTA 10. Ribonuclease pancreatic Pharmacological action: unknown Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA Organism class: human UniProt ID: P07998 Gene: RNASE1 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 11. Pectate lyase Pharmacological action: unknown Organism class: bacterial UniProt ID: Q9X592 Gene: pelA Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 12. Trypsin-2 Pharmacological action: unknown Organism class: human UniProt ID: P07478 Gene: PRSS2 SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 13. Gag polyprotein Pharmacological action: unknown Organism class: viral UniProt ID: P05893 Gene: gag Protein Sequence: FASTA SNPs: SNPJam Report 14. Aldehyde oxidoreductase Pharmacological action: unknown An aldehyde + H(2)O + acceptor = a carboxylate + reduced acceptor Organism class: bacterial UniProt ID: Q46509 Gene: mop Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 15. Phospholipase A2, membrane associated Pharmacological action: unknown Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides Organism class: human UniProt ID: P14555 Gene: PLA2G2A Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 16. Ganglioside GM2 activator Pharmacological action: unknown Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3 Organism class: human UniProt ID: P17900 Gene: GM2A Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 17. Bacillolysin Pharmacological action: unknown Extracellular zinc metalloprotease Organism class: bacterial UniProt ID: P43133 Gene: nprS Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 18. Scaffolding dockerin binding protein A Pharmacological action: unknown Organism class: bacterial UniProt ID: P71143 Gene: sdbA Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 19. Chitotriosidase-1 Pharmacological action: unknown Degrades chitin and chitotriose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity Organism class: human UniProt ID: Q13231 Gene: CHIT1 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 20. Alr1529 protein Pharmacological action: unknown Organism class: bacterial UniProt ID: Q8YWS4 Gene: alr1529 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 21. L-xylulose reductase Pharmacological action: unknown Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L- xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules Organism class: human UniProt ID: Q7Z4W1 Gene: DCXR Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 22. Peroxiredoxin-6 Pharmacological action: unknown Organism class: human UniProt ID: P30041 Gene: PRDX6 SNPs: SNPJam Report References: Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 23. Hypothetical protein Pharmacological action: unknown Organism class: bacterial UniProt ID: Q9WZD5 Gene: TM_0667 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 24. Tumor necrosis factor Pharmacological action: unknown Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin 1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation Organism class: human UniProt ID: P01375 Gene: TNF Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 25. Tartrate-resistant acid phosphatase type 5 Pharmacological action: unknown Organism class: human UniProt ID: P13686 Gene: ACP5 SNPs: SNPJam Report References: Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 26. Adenosylhomocysteinase Pharmacological action: unknown Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine Organism class: human UniProt ID: P23526 Gene: AHCY Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 27. Spliceosome RNA helicase BAT1 Pharmacological action: unknown Organism class: human UniProt ID: Q13838 Gene: DDX39B SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 28. DNA mismatch repair protein mutL Pharmacological action: unknown This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of the final effector complex. The ATPase activity of mutL is stimulated by DNA Organism class: bacterial UniProt ID: P23367 Gene: mutL Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 29. Pol polyprotein Pharmacological action: unknown During replicative cycle of retroviruses, the reverse- transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase Organism class: viral UniProt ID: Q04095 Gene: gag-pro-pol Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 30. Lysozyme Pharmacological action: unknown Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity. Acts as a transglycosylase. Cleaves glycosidic bonds between the C1 of N-acetyl muramic acids (NAM) and C4 of N-acetyl glucosamines (NAG) of the peptidoglycan of the bacterial walls Organism class: viral UniProt ID: P03706 Gene: R Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 31. Glucarate dehydratase Pharmacological action: unknown Catalyzes the dehydration of glucarate to 5-keto-4- deoxy-D-glucarate (5-kdGluc). Also acts on L-idarate Organism class: bacterial UniProt ID: P0AES2 Gene: gudD Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

Targets

1. Hypothetical protein

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q9I1L3 Link_out

Gene: kguE
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

2. mRNA-capping enzyme

Pharmacological action: unknown
Organism class: human
UniProt ID: O60942 Link_out

Gene: RNGTT
SNPs: SNPJam Report Link_out

References:

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

3. FMN-dependent NADH-azoreductase

Pharmacological action: unknown

Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity. The enzyme can reduce ethyl red and methyl red, but is not able to convert sulfonated azo dyes

Organism class: bacterial
UniProt ID: P41407 Link_out

Gene: azoR
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

4. Transcription antitermination protein nusG

Pharmacological action: unknown

Influences transcription termination and antitermination. Acts as a component of the transcription complex, and interacts with the termination factor rho and RNA polymerase (By similarity)

Organism class: bacterial
UniProt ID: O67757 Link_out

Gene: nusG
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

5. 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase

Pharmacological action: unknown
Organism class: human
UniProt ID: Q9BV57 Link_out

Gene: ADI1
SNPs: SNPJam Report Link_out

References:

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

6. GTP cyclohydrolase I

Pharmacological action: unknown

Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown

Organism class: human
UniProt ID: P30793 Link_out

Gene: GCH1 Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

7. Growth/differentiation factor 5

Pharmacological action: unknown

Could be involved in bone formation

Organism class: human
UniProt ID: P43026 Link_out

Gene: GDF5
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

8. Subtilisin BPN'

Pharmacological action: unknown

Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides. Has a high substrate specificity to fibrin

Organism class: bacterial
UniProt ID: P00782 Link_out

Gene: apr
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

9. Ig kappa chain V-IV region Len

Pharmacological action: unknown
Organism class: human
UniProt ID: P01625 Link_out

Protein Sequence: FASTA

10. Ribonuclease pancreatic

Pharmacological action: unknown

Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA

Organism class: human
UniProt ID: P07998 Link_out

Gene: RNASE1
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

11. Pectate lyase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q9X592 Link_out

Gene: pelA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

12. Trypsin-2

Pharmacological action: unknown
Organism class: human
UniProt ID: P07478 Link_out

Gene: PRSS2
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

13. Gag polyprotein

Pharmacological action: unknown
Organism class: viral
UniProt ID: P05893 Link_out

Gene: gag
Protein Sequence: FASTA
SNPs: SNPJam Report Link_out

14. Aldehyde oxidoreductase

Pharmacological action: unknown

An aldehyde + H(2)O + acceptor = a carboxylate + reduced acceptor

Organism class: bacterial
UniProt ID: Q46509 Link_out

Gene: mop
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

15. Phospholipase A2, membrane associated

Pharmacological action: unknown

Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides

Organism class: human
UniProt ID: P14555 Link_out

Gene: PLA2G2A Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

16. Ganglioside GM2 activator

Pharmacological action: unknown

Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3

Organism class: human
UniProt ID: P17900 Link_out

Gene: GM2A Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

17. Bacillolysin

Pharmacological action: unknown

Extracellular zinc metalloprotease

Organism class: bacterial
UniProt ID: P43133 Link_out

Gene: nprS
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

18. Scaffolding dockerin binding protein A

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: P71143 Link_out

Gene: sdbA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

19. Chitotriosidase-1

Pharmacological action: unknown

Degrades chitin and chitotriose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity

Organism class: human
UniProt ID: Q13231 Link_out

Gene: CHIT1 Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

20. Alr1529 protein

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q8YWS4 Link_out

Gene: alr1529
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

21. L-xylulose reductase

Pharmacological action: unknown

Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L- xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules

Organism class: human
UniProt ID: Q7Z4W1 Link_out

Gene: DCXR Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

22. Peroxiredoxin-6

Pharmacological action: unknown
Organism class: human
UniProt ID: P30041 Link_out

Gene: PRDX6
SNPs: SNPJam Report Link_out

References:

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

23. Hypothetical protein

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q9WZD5 Link_out

Gene: TM_0667
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

24. Tumor necrosis factor

Pharmacological action: unknown

Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin 1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation

Organism class: human
UniProt ID: P01375 Link_out

Gene: TNF

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

25. Tartrate-resistant acid phosphatase type 5

Pharmacological action: unknown
Organism class: human
UniProt ID: P13686 Link_out

Gene: ACP5
SNPs: SNPJam Report Link_out

References:

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

26. Adenosylhomocysteinase

Pharmacological action: unknown

Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine

Organism class: human
UniProt ID: P23526 Link_out

Gene: AHCY Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

27. Spliceosome RNA helicase BAT1

Pharmacological action: unknown
Organism class: human
UniProt ID: Q13838 Link_out

Gene: DDX39B
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

28. DNA mismatch repair protein mutL

Pharmacological action: unknown

This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of the final effector complex. The ATPase activity of mutL is stimulated by DNA

Organism class: bacterial
UniProt ID: P23367 Link_out

Gene: mutL
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

29. Pol polyprotein

Pharmacological action: unknown

During replicative cycle of retroviruses, the reverse- transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase

Organism class: viral
UniProt ID: Q04095 Link_out

Gene: gag-pro-pol
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

30. Lysozyme

Pharmacological action: unknown

Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity. Acts as a transglycosylase. Cleaves glycosidic bonds between the C1 of N-acetyl muramic acids (NAM) and C4 of N-acetyl glucosamines (NAG) of the peptidoglycan of the bacterial walls

Organism class: viral
UniProt ID: P03706 Link_out

Gene: R
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

31. Glucarate dehydratase

Pharmacological action: unknown

Catalyzes the dehydration of glucarate to 5-keto-4- deoxy-D-glucarate (5-kdGluc). Also acts on L-idarate

Organism class: bacterial
UniProt ID: P0AES2 Link_out

Gene: gudD
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

Enzymes
Searched, but no enzymes found.

Transporters
Searched, but no transporters found.

Carriers
Searched, but no carriers found.

Comments

Drug created on June 13, 2005 07:24 / Updated on October 11, 2011 15:59

This project is supported by Genome Alberta & Genome Canada, a not-for-profit organization that is leading Canada's national genomics strategy with $600 million in funding from the federal government. This project is also supported in part by GenomeQuest, Inc., an enterprise genomic information company serving the life science community.