Displaying drugs 126 - 150 of 4338 in total
Etodolac
Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis.
Approved
Investigational
Vet approved
Choline C-11
Choline C 11 Injection is a radioactive diagnostic agent for positron emission tomography (PET) imaging of pat ients with suspected prostate cancer recurrence and non-informative bone scintigraphy, computerized tomography (CT) or magnetic resonance imaging.
Approved
Trifluridine
Trifluridine is a fluorinated pyrimidine nucleoside that is structurally related to idoxuridine . It is an active antiviral agent in ophthalmic solutions used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus. It displays effective antiviral activity against Herpes simplex virus type 1...
Approved
Investigational
Matched Description: … uptake to aberrate DNA function during cell replication [F649]. ... thymidine-based nucleoside metabolic inhibitor that gets incorporated into DNA of cancer cells following cell …
Tegafur-uracil
Tegafur-uracil is an anti-tumor compound containing tegafur (1-(2-tetrahydrofuryl)-5-fluorouracil) and uracil in a molar ratio of 1:4. It was developed as an anti-cancer therapy by Taiho Pharmaceutical Co Ltd. It is approved in different countries but it is not yet approved by the FDA, Health Canada or EMA.
Approved
Investigational
Matched Description: … Tegafur-uracil is an anti-tumor compound containing tegafur (1-(2-tetrahydrofuryl)-5-fluorouracil) and …
Methotrexate
Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division in neoplastic diseases such...
Approved
Matched Description: … division in neoplastic diseases such as breast cancer and non-Hodgkin's lymphoma. ... [A180322] This inhibition leads to suppression of inflammation as well as prevention of cell division ... of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell …
Hydroxyethyl ethylcellulose
Hydroxyethyl ethylcellulose modulates bacterial binding to salivary pellicle; moderately effective in preventing plaque formation.
Approved
Experimental
Belimumab
Belimumab is a fully human recombinant IgG1λ monoclonal antibody that inhibits soluble human B lymphocyte stimulator protein (BLyS, also referred to as BAFF and TNFSF13B), a B cell survival factor. BLyS levels are often elevated in immunodeficient and autoimmune disorders, such as systemic lupus erythematosus (SLE).[A251495, L42705] By binding to...
Approved
Matched Description: … Belimumab is a fully human recombinant IgG1λ monoclonal antibody that inhibits soluble human B lymphocyte ... It is produced by recombinant DNA technology in a murine cell (NS0) expression system. ... stimulator protein (BLyS, also referred to as BAFF and TNFSF13B), a B cell survival factor. …
Magnesium citrate
Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under...
Approved
Matched Mixtures name: … Super-cell …
Chromium
Chromium is a transition element with the chemical symbol Cr and atomic number 24 that belongs to Group 6 of the periodic table. It is used in various chemical, industrial and manufacturing applications such as wood preservation and metallurgy. The uses of chromium compounds depend on the valency of chromium,...
Approved
Matched Description: … hexavalent Cr (VI) compounds are used as corrosion inhibitors in commercial settings and are known to be human …
Matched Categories: … Cell-mediated Immunity …
Matched Categories: … Cell-mediated Immunity …
Calaspargase pegol
Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparaginase treatment...
Approved
Toripalimab
The proliferation of some cancers can be attributed, at least in part, to the suppression of host tumor surveillance. One mechanism by which this occurs is through the overexpression of programmed cell death ligand (PD-L1) - the binding of PD-L1 (and PD-L2) to its target receptor (PD-1) results in the...
Approved
Investigational
Matched Description: … The proliferation of some cancers can be attributed, at least in part, to the suppression of host tumor ... One mechanism by which this occurs is through the overexpression of programmed cell death ligand (PD-L1 ... proliferation and cytokine production, and thus its overexpression can inhibit T-cell-mediated immune …
Aminoglutethimide
An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant properties. (From Martindale,...
Approved
Investigational
Matched Description: … Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. …
Arbutin
Extracted from the dried leaves of bearberry plant in the genus Arctostaphylos and other plants commonly in the Ericaceae family, arbutin is a beta-D-glucopyranoside of DB09526. It is found in foods, over-the-counter drugs, and herbal dietary supplements . Most commonly, it is an active ingredient in skincare and cosmetic products...
Approved
Cantharidin
Cantharidin is a naturally occurring odorless, colorless fatty substance of the terpenoid class that is produced as an oral fluid in the alimentary canal of the male blister beetle.[A32891, A32892] For its natural purpose, the male blister beetle secretes and presents the cantharidin to a female beetle as a copulatory...
Approved
Investigational
Nelfinavir
Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles.
Approved
Ceftolozane
Ceftolozane is a semi-synthetic broad-spectrum fifth generation cephalosporin. It was approved by the FDA in 2014 for use in combination with Tazobactam for the treatment of serious infections, such as intra-abdominal infections and complicated urinary tract infections. The manufacturer of this drug is Cubist Pharmaceuticals. Most recently, in June 2019,...
Approved
Investigational
Raxibacumab
Raxibacumab is a human IgG1λ monoclonal antibody that binds the protective antigen (PA) component of B. anthracis toxin. Raxibacumab has a molecular weight of approximately 146 kilodaltons. Raxibacumab is produced by recombinant DNA technology in a murine cell expression system. FDA approved on December 14, 2012.
Approved
Matched Description: … Raxibacumab is produced by recombinant DNA technology in a murine cell expression system. ... Raxibacumab is a human IgG1λ monoclonal antibody that binds the protective antigen (PA) component of …
Belinostat
Belinostat is a novel agent that inhibits the enzyme histone deacetylase (HDAC) with a sulfonamide-hydroxamide structure. It was developed as an orphan drug to target hematological malignancies and solid tumors by TopoTarget. The safety and efficacy of belinostat is currently being evaluated for use in combination with traditional front-line therapies...
Approved
Investigational
Matched Description: … It was US-approved in July 2014 as a therapeutic agent for relapsed or refractory peripheral T-cell lymphoma …
Idarubicin
An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity.
Approved
Matched Description: … The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential …
Muromonab
Murine monoclonal antibody specific to CD3 T-cell lymphocyte antigens. More specifically it is a purified murine (mouse) monoclonal antibody, directed against the CD3 (T3) receptor on the surface of human T-cells (T-lymphocytes) cultured using the murine ascites method. Muromonab is 93% monomeric immune globulin G type 2a (IgG2a).
Approved
Investigational
Matched Description: … Murine monoclonal antibody specific to CD3 T-cell lymphocyte antigens. ... purified murine (mouse) monoclonal antibody, directed against the CD3 (T3) receptor on the surface of human …
Diethylamino hydroxybenzoyl hexyl benzoate
Diethylamino hydroxybenzoyl hexyl benzoate is a UV filter with high absorption in the UV-A range. Minimizing the overexposure of human skin to ultraviolet radiation that may lead to acute and chronic photodamage, diethylamino hydroxybenzoyl hexyl benzoate is an oil-soluble UV filter that may be incorporated in the oil phase of...
Approved
Matched Description: … Minimizing the overexposure of human skin to ultraviolet radiation that may lead to acute and chronic …
Matched Mixtures name: … Ohui The First Cell Revolution Age Control Sun Block …
Matched Mixtures name: … Ohui The First Cell Revolution Age Control Sun Block …
Cisplatin
Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also includes carboplatin and oxaliplatin.
Approved
Matched Description: … lung cancer, and ovarian cancer), lymphomas and germ cell tumors. ... chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell …
Olaparib
Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Olaparib...
Approved
Matched Description: … work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell ... A246015]
Olaparib is used to treat a number of BRCA-associated tumours, including ovarian cancer, breast …
Ofloxacin
A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Approved
Arzoxifene
Approved
Investigational
Displaying drugs 126 - 150 of 4338 in total