Carbonic anhydrase 2

Details

Name
Carbonic anhydrase 2
Synonyms
  • 4.2.1.1
  • CA-II
  • CAC
  • Carbonate dehydratase II
  • Carbonic anhydrase C
  • Carbonic anhydrase II
Gene Name
CA2
Organism
Human
Amino acid sequence
>lcl|BSEQ0018937|Carbonic anhydrase 2
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
Number of residues
260
Molecular Weight
29245.895
Theoretical pI
7.47
GO Classification
Functions
zinc ion binding / carbonate dehydratase activity / arylesterase activity
Processes
positive regulation of dipeptide transmembrane transport / angiotensin-activated signaling pathway / positive regulation of synaptic transmission, GABAergic / kidney development / response to estrogen / positive regulation of osteoclast differentiation / positive regulation of cellular pH reduction / cellular response to fluid shear stress / odontogenesis of dentin-containing tooth / positive regulation of bone resorption / morphogenesis of an epithelium / small molecule metabolic process / response to zinc ion / secretion / bicarbonate transport / regulation of chloride transport / one-carbon metabolic process / regulation of intracellular pH / response to pH / regulation of anion transport
Components
axon / cytoplasm / microvillus / plasma membrane / extracellular space / apical part of cell / cytosol / extracellular exosome / myelin sheath / basolateral plasma membrane
General Function
Zinc ion binding
Specific Function
Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0018938|Carbonic anhydrase 2 (CA2)
ATGTCCCATCACTGGGGGTACGGCAAACACAACGGACCTGAGCACTGGCATAAGGACTTC
CCCATTGCCAAGGGAGAGCGCCAGTCCCCTGTTGACATCGACACTCATACAGCCAAGTAT
GACCCTTCCCTGAAGCCCCTGTCTGTTTCCTATGATCAAGCAACTTCCCTGAGGATCCTC
AACAATGGTCATGCTTTCAACGTGGAGTTTGATGACTCTCAGGACAAAGCAGTGCTCAAG
GGAGGACCCCTGGATGGCACTTACAGATTGATTCAGTTTCACTTTCACTGGGGTTCACTT
GATGGACAAGGTTCAGAGCATACTGTGGATAAAAAGAAATATGCTGCAGAACTTCACTTG
GTTCACTGGAACACCAAATATGGGGATTTTGGGAAAGCTGTGCAGCAACCTGATGGACTG
GCCGTTCTAGGTATTTTTTTGAAGGTTGGCAGCGCTAAACCGGGCCTTCAGAAAGTTGTT
GATGTGCTGGATTCCATTAAAACAAAGGGCAAGAGTGCTGACTTCACTAACTTCGATCCT
CGTGGCCTCCTTCCTGAATCCTTGGATTACTGGACCTACCCAGGCTCACTGACCACCCCT
CCTCTTCTGGAATGTGTGACCTGGATTGTGCTCAAGGAACCCATCAGCGTCAGCAGCGAG
CAGGTGTTGAAATTCCGTAAACTTAACTTCAATGGGGAGGGTGAACCCGAAGAACTGATG
GTGGACAACTGGCGCCCAGCTCAGCCACTGAAGAACAGGCAAATCAAAGCTTCCTTCAAA
TAA
Chromosome Location
8
Locus
8q22
External Identifiers
ResourceLink
UniProtKB IDP00918
UniProtKB Entry NameCAH2_HUMAN
GenBank Protein ID179780
GenBank Gene IDM77181
GenAtlas IDCA2
HGNC IDHGNC:1373
General References
Not Available

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00869DorzolamideapprovedyesinhibitorDetails
DB01031Ethinamateapproved, illicit, withdrawnyesinhibitorDetails
DB00232MethyclothiazideapprovedunknowninhibitorDetails
DB00273TopiramateapprovedyesinhibitorDetails
DB00436BendroflumethiazideapprovedunknowninhibitorDetails
DB00562BenzthiazideapprovedunknowninhibitorDetails
DB00606CyclothiazideapprovedunknowninhibitorDetails
DB00774Hydroflumethiazideapproved, investigationalunknowninhibitorDetails
DB00880Chlorothiazideapproved, vet_approvedyesinhibitorDetails
DB00999Hydrochlorothiazideapproved, vet_approvedunknowninhibitorDetails
DB01021Trichlormethiazideapproved, vet_approvedunknowninhibitorDetails
DB01119DiazoxideapprovedyesinhibitorDetails
DB01194BrinzolamideapprovedyesinhibitorDetails
DB016714-(Hydroxymercury)Benzoic AcidexperimentalunknownDetails
DB01748N-Benzyl-4-Sulfamoyl-BenzamideexperimentalunknownDetails
DB017844-FlourobenzenesulfonamideexperimentalunknownDetails
DB01942Formic Acidapproved, experimental, investigationalunknownDetails
DB01964AL5424experimentalunknownDetails
DB02069N-(2-Flouro-Benzyl)-4-Sulfamoyl-BenzamideexperimentalunknownDetails
DB020873,5-DifluorobenzenesulfonamideexperimentalunknownDetails
DB02220AL7089AexperimentalunknownDetails
DB022214-(Aminosulfonyl)-N-[(2,4,6-Trifluorophenyl)Methyl]-BenzamideexperimentalunknownDetails
DB02292IrosustatinvestigationalunknownDetails
DB024294-(Aminosulfonyl)-N-[(4-Fluorophenyl)Methyl]-BenzamideexperimentalunknownDetails
DB02479(R)-N-(3-Indol-1-Yl-2-Methyl-Propyl)-4-Sulfamoyl-BenzamideexperimentalunknownDetails
DB02535Aminodi(Ethyloxy)EthylaminocarbonylbenzenesulfonamideexperimentalunknownDetails
DB02602AL7182experimentalunknownDetails
DB02610N-(2,3,4,5,6-Pentaflouro-Benzyl)-4-Sulfamoyl-BenzamideexperimentalunknownDetails
DB02679CyanamideexperimentalunknownDetails
DB028614-(Aminosulfonyl)-N-[(3,4,5-Trifluorophenyl)Methyl]-BenzamideexperimentalunknownDetails
DB02866DansylamideexperimentalunknownDetails
DB02894Sulfamic Acid 2,3-O-(1-Methylethylidene)-4,5-O-Sulfonyl-Beta-Fructopyranose EsterexperimentalunknownDetails
DB02986N-(2-Thienylmethyl)-2,5-ThiophenedisulfonamideexperimentalunknownDetails
DB030394-(Aminosulfonyl)-N-[(2,5-Difluorophenyl)Methyl]-BenzamideexperimentalunknownDetails
DB03221AL7099AexperimentalunknownDetails
DB03262Al-6619, [2h-Thieno[3,2-E]-1,2-Thiazine-6-Sulfonamide,2-(3-Hydroxyphenyl)-3-(4-Morpholinyl)-, 1,1-Dioxide]experimentalunknownDetails
DB032702,6-DifluorobenzenesulfonamideexperimentalunknownDetails
DB032941-Methyl-3-Oxo-1,3-Dihydro-Benzo[C]Isothiazole-5-Sulfonic Acid AmideexperimentalunknownDetails
DB03333(4-sulfamoyl-phenyl)-thiocarbamic acid O-(2-thiophen-3-yl-ethyl) esterexperimentalunknownDetails
DB033854-MethylimidazoleexperimentalunknownDetails
DB03526AL5927experimentalunknownDetails
DB035941,2,4-TriazoleexperimentalunknownDetails
DB03596N-[2-(1h-Indol-5-Yl)-Butyl]-4-Sulfamoyl-BenzamideexperimentalunknownDetails
DB03598Al-6629, [2h-Thieno[3,2-E]-1,2-Thiazine-6-Sulfonamide,2-(3-Methoxyphenyl)-3-(4-Morpholinyl)-, 1,1-Dioxide]experimentalunknownDetails
DB036974-Sulfonamide-[1-(4-Aminobutane)]BenzamideexperimentalunknownDetails
DB03844N-(2,6-Diflouro-Benzyl)-4-Sulfamoyl-BenzamideexperimentalunknownDetails
DB03877AL4623experimentalunknownDetails
DB03904Ureaapproved, investigationalunknownDetails
DB03950(S)-N-(3-Indol-1-Yl-2-Methyl-Propyl)-4-Sulfamoyl-BenzamideexperimentalunknownDetails
DB03975Mercuribenzoic AcidexperimentalunknownDetails
DB040024-Sulfonamide-[4-(Thiomethylaminobutane)]BenzamideexperimentalunknownDetails
DB04081(4s-Trans)-4-(Methylamino)-5,6-Dihydro-6-Methyl-4h-Thieno(2,3-B)Thiopyran-2-Sulfonamide-7,7-DioxideexperimentalunknownDetails
DB04089AL5300experimentalunknownDetails
DB041804-(Aminosulfonyl)-N-[(2,4-Difluorophenyl)Methyl]-BenzamideexperimentalunknownDetails
DB042033-Mercuri-4-AminobenzenesulfonamideexperimentalunknownDetails
DB04371AL6528experimentalunknownDetails
DB043943-Nitro-4-(2-Oxo-Pyrrolidin-1-Yl)-BenzenesulfonamideexperimentalunknownDetails
DB045494-(Aminosulfonyl)-N-[(2,3,4-Trifluorophenyl)Methyl]-BenzamideexperimentalunknownDetails
DB01325QuinethazoneapprovedyesinhibitorDetails
DB046004-[(3-BROMO-4-O-SULFAMOYLBENZYL)(4-CYANOPHENYL)AMINO]-4H-[1,2,4]-TRIAZOLEexperimentalunknownDetails
DB046014-[(4-O-SULFAMOYLBENZYL)(4-CYANOPHENYL)AMINO]-4H-[1,2,4]-TRIAZOLEexperimentalunknownDetails
DB047631-N-(4-SULFAMOYLPHENYL-ETHYL)-2,4,6-TRIMETHYLPYRIDINIUMexperimentalunknownDetails
DB00909Zonisamideapproved, investigationalunknowninhibitorDetails
DB068915-{[(4-AMINO-3-CHLORO-5-FLUOROPHENYL)SULFONYL]AMINO}-1,3,4-THIADIAZOLE-2-SULFONAMIDEexperimentalunknownDetails
DB069542-(cycloheptylmethyl)-1,1-dioxido-1-benzothiophen-6-yl sulfamateexperimentalunknownDetails
DB07048N-[(2R)-5-(aminosulfonyl)-2,3-dihydro-1H-inden-2-yl]-2-propylpentanamideexperimentalunknownDetails
DB070505-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamideexperimentalunknownDetails
DB07363THIOPHENE-2,5-DISULFONIC ACID 2-AMIDE-5-(4-METHYL-BENZYLAMIDE)experimentalunknownDetails
DB074674-chloro-N-[(2S)-2-methyl-2,3-dihydro-1H-indol-1-yl]-3-sulfamoylbenzamideexperimentalunknownDetails
DB07476N-[4-(AMINOSULFONYL)PHENYL]-2-MERCAPTOBENZAMIDEexperimentalunknownDetails
DB07596(17beta)-17-(cyanomethyl)-2-methoxyestra-1(10),2,4-trien-3-yl sulfamateexperimentalunknownDetails
DB076325-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamideexperimentalunknownDetails
DB07710PHENYLALANYLAMINODI(ETHYLOXY)ETHYL BENZENESULFONAMIDEAMINOCARBONYLBENZENESULFONAMIDEexperimentalunknownDetails
DB07742N-(2,3-DIFLUORO-BENZYL)-4-SULFAMOYL-BENZAMIDEexperimentalunknownDetails
DB080462-chloro-5-[(1S)-1-hydroxy-3-oxo-2H-isoindol-1-yl]benzenesulfonamideexperimentalunknownDetails
DB080832-(1,3-thiazol-4-yl)-1H-benzimidazole-5-sulfonamideexperimentalunknownDetails
DB08155N-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}ACETAMIDEexperimentalunknownDetails
DB081563-[4-(AMINOSULFONYL)PHENYL]PROPANOIC ACIDexperimentalunknownDetails
DB08157ETHYL 3-[4-(AMINOSULFONYL)PHENYL]PROPANOATEexperimentalunknownDetails
DB08165indane-5-sulfonamideexperimentalunknownDetails
DB082024-({[(4-METHYLPIPERAZIN-1-YL)AMINO]CARBONOTHIOYL}AMINO)BENZENESULFONAMIDEexperimentalunknownDetails
DB08301N-({[4-(AMINOSULFONYL)PHENYL]AMINO}CARBONYL)-4-METHYLBENZENESULFONAMIDEexperimentalunknownDetails
DB08329SulthiameexperimentalunknownDetails
DB08416(9BETA,13ALPHA,14BETA,17ALPHA)-2-METHOXYESTRA-1,3,5(10)-TRIENE-3,17-DIYL DISULFAMATEexperimentalunknownDetails
DB08418(4aS,4bR,10bS,12aS)-12a-methyl-1,3-dioxo-2-(pyridin-3-ylmethyl)-1,2,3,4,4a,4b,5,6,10b,11,12,12a-dodecahydronaphtho[2,1-f]isoquinolin-8-yl sulfamateexperimentalunknownDetails
DB086456-CHLORO-3-(DICHLOROMETHYL)-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDEexperimentalunknownDetails
DB086592-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamideexperimentalunknownDetails
DB087656-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDEexperimentalunknownDetails
DB087824-(2-AMINOETHYL)BENZENESULFONAMIDEexperimentalunknownDetails
DB00819Acetazolamideapproved, vet_approvedyesinhibitorDetails
DB00311EthoxzolamidewithdrawnyesinhibitorDetails
DB00703MethazolamideapprovedyesinhibitorDetails
DB01144Diclofenamideapproved, investigationalyesinhibitorDetails
DB00695Furosemideapproved, vet_approvedunknownDetails
DB08846Ellagic AcidinvestigationalunknowninhibitorDetails
DB09460Sodium carbonateapprovedunknowninhibitorDetails
DB09472Sodium sulfateapproved, vet_approvedyesinhibitorDetails
DB00482Celecoxibapproved, investigationalunknowninhibitorDetails
DB00391Sulpirideapproved, investigationalunknowninhibitorDetails
DB00580Valdecoxibapproved, investigational, withdrawnunknowninhibitorDetails