Nerve Tissue Proteins

DrugDrug NameDrug Description
DB00007LeuprolideA protein-based luteinizing hormone antagonist used to treat prostate cancer, endometriosis, and precocious puberty.
DB00010SermorelinFor the treatment of dwarfism, prevention of HIV-induced weight loss
DB00014GoserelinA synthetic analog of luteinizing hormone-releasing hormone used to treat breast cancer and prostate cancer by reducing secretion of gonadotropins from the pituitary.
DB00017Salmon CalcitoninA synthetic peptide form of calcitonin used to inhibit bone resorption in the treatment of hypercalcemia, osteoporosis, and Paget's disease.
DB00035DesmopressinA synthetic analog of vasopressin used to reduce renal excretion of water in central diabetes insipidus and nocturia.
DB00050CetrorelixA synthetic peptide antagonist of gonadotropin releasing hormone used to prevent luteinizing hormone surges in women undergoing assisted reproduction therapy.
DB00067VasopressinA peptide hormone used to increase blood pressure in patients with vasodilatory shock who are resistant to fluid and catecholamine therapy.
DB00093FelypressinFor use as an alternative to adrenaline as a localising agent, provided that local ischaemia is not essential.
DB00183PentagastrinA gastrin-like molecule used as a diagnostic aid for the evaluation of gastric acid secretory function, gastric hypersecretion, and Zollinger-Ellison tumors.
DB00644GonadorelinA synthetic GnRH used to test the function of gonadotropes and the pituitary.
DB00666NafarelinA gonadotropin releasing hormone agonist used to treat central precocious puberty.
DB00855Aminolevulinic acidA porphyrin precursor used to treat actinic keratosis of the face, scalp, and upper extremities, as well as to visualize a glioma.
DB01284TetracosactideA diagnostic agent used in the screening of patients presumed to have adrenocortical insufficiency.
DB01285CorticotropinA diagnostic agent used in the screening of patients presumed to have adrenocortical insufficiency.
DB02638TerlipressinCommonly used to stop bleeding of varices in the food pipe (oesophagus).
DB04894VapreotideFor the treatment of esophageal variceal bleeding in patients with cirrhotic liver disease and has also shown efficacy in the treatment of patients with AIDS-related diarrhea.
DB04899NesiritideA recombinant natriuretic peptide used for the treatment of patients with acutely decompensated congestive heart failure who have dyspnea at rest or with minimal activity.
DB04914G17DTIntended for the treatment of various forms of cancer.
DB04921DirucotideFor the treatment of multiple sclerosis (MS).
DB05155CR665Investigated for use/treatment in pain (acute or chronic).
DB05344Ciliary neurotrophic factorInvestigated for use/treatment in eye disorders/infections, macular degeneration, and retinal disorders (unspecified).
DB05394CorticorelinInvestigated for use/treatment in brain cancer and neurologic disorders.
DB06196IcatibantA bradykinin B2 receptor antagonist used to treat acute episodes of swelling and inflammation associated with hereditary angioedema (HAE).
DB06260AviptadilNot Annotated
DB06379Calcitonin gene-related peptideInvestigated for use/treatment in myocardial infarction, heart disease, and asthma.
DB06549LabradimilInvestigated for use/treatment in brain cancer and pediatric indications.
DB06663PasireotideA somatostatin analog used in the treatment of Cushing’s disease, specifically for those patients whom pituitary surgery is not appropriate.
DB06719BuserelinA LHRH agonist used for the palliative treatment of hormone-dependent advanced carcinoma of the prostate gland in males and treatment of endometriosis in females.
DB06763SaralasinNot Annotated
DB06785GanirelixA GnRH antagonist used in assisted reproduction in women undergoing controlled ovarian hyperstimulation to control ovulation by inhibiting the premature LH surges.
DB06788HistrelinA GnRH agonist found in subcutaneous implants used for the treatment of pediatric patients with central precocious puberty and the palliative treatment of advanced prostate cancer.
DB06791LanreotideA somatostatin analog used for the treatment of unresectable, well- or moderately-differentiated, locally advanced or metastatic gastroenteropancreatic neuroendocrine tumors and acromegaly.
DB06825TriptorelinA GnRH agonist indicated for the palliative treatment of advanced prostate cancer.
DB08856DADLEA delta-selective opioid (ANALGESICS, OPIOID). It can cause transient depression of mean arterial blood pressure and heart rate.
DB08861DPDPEA heterodetic cyclic peptide that is a cyclic enkephalin analogue, having D-penicillaminyl residues located at positions 2 and 5, which form the heterocycle via a disulfide bond.
DB08869TesamorelinA growth hormone releasing factor (GRF) analog used to reduce excessive abdominal fat in HIV patients who have developed lipodystrophy.
DB09067Corticorelin ovine triflutateA synthetic corticotropin-releasing hormone used for diagnostic purposes in differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushing's syndrome.
DB09099SomatostatinA naturally-occurring peptide hormone used for the symptomatic treatment of acute bleeding from esophageal varices.
DB09221PolaprezincPeptic ulcer disease, dyspepsia .
DB09421ProtirelinA synthetic analogue of thyrotropin-releasing hormone that has been used during diagnostic tests to evaluate function of the thyroid gland.
DB09527Secretin porcineA secretin hormone used to stimulate pancreatic or gastric secretions to diagnose exocrine pancreas dysfunction, gastrinoma, and abnormalities in the bile and pancreatic ducts.
DB11510DeslorelinDeslorelin acetate is an injectable gonadotropin releasing hormone super-agonist also known as an LHRH agonist. It stops the production of sex hormones.
DB11653BremelanotideBremelanotide is indicated to treat premenopausal women with hypoactive sexual desire disorder that is not due to a medical or psychiatric condition, problems with the relationship, or the effects of...
DB11695CarnosineCarnosine has been investigated for the treatment of Gulf War Illness.
DB11700SetmelanotideSetmelanotide has been investigated for the treatment of obesity.
DB11724BombesinBombesin is under investigation in clinical trial NCT01205321 (PET/CT Imaging for Radiation Dosimetry, Plasma Pharmacokinetics, Biodistribution, Safety and Tolerability and Diagnostic Performance of BAY86-7548 in Patients With Prostate Cancer and...
DB11788Neuropeptide YNeuropeptide Y is under investigation for the basic science of Type 2 Diabetes Mellitus.
DB11842Angiotensin IIA peptide hormone of the RAAS system used to raise blood pressure in septic or other forms of shock.
DB11975TAK-448TAK-448 has been used in trials studying the treatment of Prostate Cancer, Low Testosterone, Prostatic Neoplasms, and Hypogonadotropic Hypogonadism.
DB12088TT-232Tln 232 is under investigation in clinical trial NCT00422786 (Phase II Study of CAP-232 in Patients With Refractory Metastatic Renal Cell Carcinoma).
DB12126BradykininBradykinin has been investigated for the basic science and treatment of Hypertension and Diabetes Type 2.
DB12495SelepressinSelepressin has been used in trials studying the treatment of Septic Shock.
DB12602PentetreotidePentetreotide has been used in trials studying the diagnostic of cushing syndrome.
DB12620Nerve Growth FactorNerve Growth Factor has been used in trials studying the prevention and treatment of Mental Handicap, Alzheimer's Disease, Traumatic Brain Injury, Cerebral Palsy Children, and Delayed Speech Development, among others.
DB12738TiplimotideTiplimotide has been used in trials studying the treatment of Multiple Sclerosis.
DB12755Zoptarelin doxorubicinZoptarelin doxorubicin has been used in trials studying the treatment of Breast Cancer, Ovarian Cancer, Prostate Cancer, Endometrial Cancer, and Urothelial Carcinoma, among others.
DB12777SomatoprimSomatoprim is under investigation for the treatment of Acromegaly.
DB12822Pancreatic PolypeptidePancreatic Polypeptide has been investigated for the treatment of Diabetes Mellitus, Type 1.
DB13033Urocortin-2Urocortin 2 has been investigated for the basic science of Heart Failure and Cardiovascular Disease.
DB13298AlsactideNot Annotated
DB13464OrnipressinNot Annotated
DB13517AngiotensinamideNot Annotated
DB13742ElcatoninNot Annotated
DB09532Secretin humanA secretin hormone used to stimulate pancreatic or gastric secretions to diagnose exocrine pancreas dysfunction, gastrinoma, and abnormalities in the bile and pancreatic ducts.
DB14642LypressinNot Annotated
DB11835Indium In-111 pentetreotideIndium In 111 pentetreotide (Octreoscan) has been used in trials studying the diagnostic of SARCOIDOSIS, Solid Tumors, and cushing syndrome.
DB05875Sar9, Met (O2)11-Substance PInvestigated for use/treatment in acute respiratory distress syndrome (ARDS) and viral infection.
DB15217Gastric inhibitory polypeptideGastric inhibitory polypeptide is under investigation in clinical trial NCT03081676 (The Effect of GIP and GLP-1 on Insulin and Glucagon Secretion in Patients With HNF1A-diabetes Treated With or Without Sulphonylurea).
DB05950Contulakin-GInvestigated for use/treatment in pain (acute or chronic).
DB11720Angiotensin 1-7TXA127 has been investigated for the treatment of Miscellaneous Peripheral Blood Cell Abnormalities.
DB12631AclerastideAclerastide has been investigated for the treatment of Diabetic Foot, Diabetic Foot Ulcers, and Foot Ulcer, Diabetic.
DB15171TirzepatideTirzepatide is under investigation in clinical trial NCT03311724 (A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes).
DrugDrug NameTargetType
DB00007LeuprolideGonadotropin-releasing hormone receptortarget
DB00007LeuprolideCytochrome P450 3A4enzyme
DB00010SermorelinGrowth hormone-releasing hormone receptortarget
DB00014GoserelinLutropin-choriogonadotropic hormone receptortarget
DB00014GoserelinGonadotropin-releasing hormone receptortarget
DB00017Salmon CalcitoninCalcitonin receptortarget
DB00035DesmopressinVasopressin V1a receptortarget
DB00035DesmopressinVasopressin V1b receptortarget
DB00035DesmopressinVasopressin V2 receptortarget
DB00035DesmopressinProstaglandin G/H synthase 1enzyme
DB00035DesmopressinProstaglandin G/H synthase 2enzyme
DB00050CetrorelixLutropin-choriogonadotropic hormone receptortarget
DB00050CetrorelixGonadotropin-releasing hormone receptortarget
DB00067VasopressinVasopressin V1a receptortarget
DB00067VasopressinVasopressin V2 receptortarget
DB00067VasopressinVasopressin V1b receptortarget
DB00067VasopressinCanalicular multispecific organic anion transporter 1transporter
DB00093FelypressinVasopressin V1a receptortarget
DB00183PentagastrinGastrin/cholecystokinin type B receptortarget
DB00183PentagastrinCholinesteraseenzyme
DB00644GonadorelinGonadotropin-releasing hormone receptortarget
DB00644GonadorelinPutative gonadotropin-releasing hormone II receptortarget
DB00666NafarelinGonadotropin-releasing hormone receptortarget
DB00666NafarelinPutative gonadotropin-releasing hormone II receptortarget
DB00855Aminolevulinic acidDelta-aminolevulinic acid dehydratasetarget
DB00855Aminolevulinic acidSolute carrier family 15 member 1transporter
DB00855Aminolevulinic acidSolute carrier family 15 member 2transporter
DB01284TetracosactideAdrenocorticotropic hormone receptortarget
DB01285CorticotropinAdrenocorticotropic hormone receptortarget
DB01285CorticotropinCorticoliberintarget
DB01285Corticotropin3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2enzyme
DB01285Corticotropin25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialenzyme
DB01285Corticotropin1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
DB01285CorticotropinCytochrome P450 3A4enzyme
DB02638TerlipressinVasopressin V1a receptortarget
DB02638TerlipressinVasopressin V2 receptortarget
DB02638TerlipressinVasopressin V1b receptortarget
DB04894VapreotideNeurokinin 1 receptortarget
DB04894VapreotideSomatostatin receptor type 2target
DB04894VapreotideSomatostatin receptor type 5target
DB04894VapreotideCytochrome P450 3A4enzyme
DB04899NesiritideAtrial natriuretic peptide receptor 1target
DB04899NesiritideAtrial natriuretic peptide receptor 2target
DB04899NesiritideAtrial natriuretic peptide receptor 3target
DB05155CR665Kappa-type opioid receptortarget
DB05394CorticorelinDopamine beta-hydroxylaseenzyme
DB06196IcatibantB2 bradykinin receptortarget
DB06196IcatibantAminopeptidase Ntarget
DB06549LabradimilB2 bradykinin receptortarget
DB06663PasireotideSomatostatin receptor type 1target
DB06663PasireotideSomatostatin receptor type 2target
DB06663PasireotideSomatostatin receptor type 3target
DB06663PasireotideSomatostatin receptor type 5target
DB06663PasireotideCytochrome P450 3A4enzyme
DB06719BuserelinLutropin-choriogonadotropic hormone receptortarget
DB06719BuserelinGonadotropin-releasing hormone receptortarget
DB06719BuserelinCytochrome P450 19A1enzyme
DB06785GanirelixGonadotropin-releasing hormone receptortarget
DB06788HistrelinGonadotropin-releasing hormone receptortarget
DB06791LanreotideSomatostatin receptor type 2target
DB06791LanreotideSomatostatin receptor type 5target
DB06791LanreotideCytochrome P450 3A4enzyme
DB06825TriptorelinGonadotropin-releasing hormone receptortarget
DB08856DADLESolute carrier organic anion transporter family member 1B1transporter
DB08861DPDPESolute carrier organic anion transporter family member 1B3transporter
DB08869TesamorelinGrowth hormone-releasing hormone receptortarget
DB09067Corticorelin ovine triflutateCorticotropin-releasing factor receptor 1target
DB09099SomatostatinSomatostatin receptor type 1target
DB09099SomatostatinSomatostatin receptor type 2target
DB09099SomatostatinSomatostatin receptor type 3target
DB09099SomatostatinSomatostatin receptor type 4target
DB09099SomatostatinSomatostatin receptor type 5target
DB09099SomatostatinP-glycoprotein 1transporter
DB09099SomatostatinCytochrome P450 3A4enzyme
DB09221PolaprezincTumor necrosis factortarget
DB09221PolaprezincInterleukin-6target
DB09221PolaprezincInterleukin-3target
DB09221PolaprezincSuperoxide dismutase [Cu-Zn]enzyme
DB09221PolaprezincHeme oxygenase 1enzyme
DB09221PolaprezincSuperoxide dismutase [Mn], mitochondrialenzyme
DB09221PolaprezincGlutathione S-transferase theta-1enzyme
DB09221PolaprezincGlutathione peroxidase 1enzyme
DB09221PolaprezincPeroxiredoxin-1enzyme
DB09221PolaprezincPeroxiredoxin-5, mitochondrialenzyme
DB09221PolaprezincVascular endothelial growth factor receptor 1target
DB09221PolaprezincBeta-nerve growth factortarget
DB09221PolaprezincPlatelet-derived growth factor receptor betatarget
DB09221PolaprezincHeat shock protein HSP 90-alphatarget
DB09221PolaprezincHeat shock protein HSP 90-betatarget
DB09421ProtirelinThyrotropin Releasing Hormone Receptortarget
DB11653BremelanotideMelanocyte-stimulating hormone receptortarget
DB11653BremelanotideMelanocortin receptor 4target
DB11653BremelanotideMelanocortin receptor 3target
DB11653BremelanotideMelanocortin receptor 5target
DB11653BremelanotideAdrenocorticotropic hormone receptortarget
DB11842Angiotensin IIType-1 angiotensin II receptortarget
DB09532Secretin humanSecretin receptortarget
DB14642LypressinVasopressin V1a receptortarget
DB14642LypressinVasopressin V2 receptortarget
DB14642LypressinVasopressin V1b receptortarget
DB14642LypressinCanalicular multispecific organic anion transporter 1transporter
DB05875Sar9, Met (O2)11-Substance PCytochrome P450 19A1enzyme
DB05875Sar9, Met (O2)11-Substance PCholinesteraseenzyme
DB05875Sar9, Met (O2)11-Substance PProstaglandin G/H synthase 2enzyme
DB05950Contulakin-GVoltage-dependent N-type calcium channel subunit alpha-1Btarget