Nerve Tissue Proteins

DrugDrug NameDrug Indication
DB00007LeuprolideFor treatment of prostate cancer, endometriosis, uterine fibroids and premature puberty
DB00010SermorelinFor the treatment of dwarfism, prevention of HIV-induced weight loss
DB00014GoserelinGoserelin is indicated for: - Use in combination with flutamide for the management of locally confined carcinoma of the prostate - Palliative treatment of advanced carcinoma of the prostate - The management of endometriosis - Use as an endometrial-thinning agent prior to endometrial ablation for dysfunctional uterine bleeding - Use in the palliative treatment of advanced breast cancer in pre- and perimenopausal women
DB00017Salmon CalcitoninUsed in the treatment of symptomatic Paget's disease for patients unresponsive to alternate treatments or intolerant to such treatments. In addition, it is used in emergency situations when serum calcium levels must be decreased quickly until the underlying condition is identified. It can also be added to existing therapeutic regimens for hypercalcemia such as intravenous fluids and furosemide, oral phosphate or corticosteroids, or other agents. Calcitonin can be used in patients with azotemia and cases where intravenous fluids would be contraindicated due to limited cardiac reserves. Also for the treatment of post-menopausal osteoporosis in women more than 5 years post-menopause.
DB00035Desmopressin- Indicated for the treatment of nocturia due to nocturnal polyuria in adults who awaken at least 2 times per night to void (intranasal). - Indicated as antidiuretic replacement therapy in the management of central cranial diabetes insipidus and for management of the temporary polyuria and polydipsia following head trauma or surgery in the pituitary region (intranasal/parenteral). - Indicated for patients with hemophilia A with factor VIII coagulant activity levels greater than 5% or mild to moderate classic von Willebrand's Disease (Type I) with factor VIII levels greater than 5% during surgical procedures and postoperatively to maintain hemostasis (parenteral).
DB00050CetrorelixFor the inhibition of premature LH surges in women undergoing controlled ovarian stimulation
DB00067VasopressinFor the treatment of enuresis, polyuria, diabetes insipidus, polydipsia and oesophageal varices with bleeding
DB00093FelypressinFor use as an alternative to adrenaline as a localising agent, provided that local ischaemia is not essential.
DB00183PentagastrinUsed as a diagnostic aid for evaluation of gastric acid secretory function
DB00644GonadorelinFor evaluating the functional capacity and response of the gonadotropes of the anterior pituitary also for evaluating residual gonadotropic function of the pituitary following removal of a pituitary tumor by surgery and/or irradiation.
DB00666NafarelinFor treatment of central precocious puberty (true precocious puberty, GnRH-dependent precocious precocity, complete isosexual precocity) in children of both sexes and for the treatment of endometriosis.
DB00855Aminolevulinic acidAminolevulinic acid plus blue light illumination using a blue light photodynamic therapy illuminator is indicated for the treatment of minimally to moderately thick actinic keratoses of the face or scalp.
DB01284TetracosactideFor use as a diagnostic agent in the screening of patients presumed to have adrenocortical insufficiency.
DB01285CorticotropinFor use as a diagnostic agent in the screening of patients presumed to have adrenocortical insufficiency.
DB02638TerlipressinCommonly used to stop bleeding of varices in the food pipe (oesophagus).
DB04894VapreotideFor the treatment of esophageal variceal bleeding in patients with cirrhotic liver disease and has also shown efficacy in the treatment of patients with AIDS-related diarrhea.
DB04899NesiritideFor the intravenous treatment of patients with acutely decompensated congestive heart failure who have dyspnea at rest or with minimal activity.
DB04914G17DTIntended for the treatment of various forms of cancer.
DB04921DirucotideFor the treatment of multiple sclerosis (MS).
DB04931AfamelanotideInvestigated for use/treatment in actinic keratosis, keratoses, skin cell studies, and skin infections/disorders.
DB05155CR665Investigated for use/treatment in pain (acute or chronic).
DB05344Ciliary neurotrophic factorInvestigated for use/treatment in eye disorders/infections, macular degeneration, and retinal disorders (unspecified).
DB05394CorticorelinInvestigated for use/treatment in brain cancer and neurologic disorders.
DB06196IcatibantApproved for use in acute attacks of hereditary angioedema (HAE). Investigated for use/treatment in angioedema, liver disease, and burns and burn infections.
DB06260AviptadilNot Available
DB06379Calcitonin gene-related peptideInvestigated for use/treatment in myocardial infarction, heart disease, and asthma.
DB06549LabradimilInvestigated for use/treatment in brain cancer and pediatric indications.
DB06663PasireotideFor the treatment of Cushing’s disease, specifically for those patients whom pituitary surgery has not been curative or is not an option.
DB06719BuserelinBuserelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, estrogen-dependent conditions (such as endometriosis or uterine fibroids), and in assisted reproduction.
DB06763SaralasinNot Available
DB06785GanirelixFor the inhibition of premature LH surges in women undergoing controlled ovarian hyperstimulation.
DB06788HistrelinAs the product Supprelin LA (FDA), histrelin is indicated for the treatment of children with central precocious puberty (CPP). As the product Vantas (FDA), histrelin is indicated for the palliative treatment of advanced prostate cancer.
DB06791LanreotideLanreotide is a somatostatin analog approved for treatment of neuroendocrine tumours and acromegaly. (2)
DB06825TriptorelinTriptorelin is indicated for the palliative treatment of advanced prostate cancer.
DB08856DADLENot Available
DB08861DPDPENot Available
DB08869TesamorelinTesamorelin acetate is a synthetic analogue of human hypothalamic Growth Hormone Releasing Factor (hGRF) indicated to induce and maintain a reduction of excess abdominal fat in HIV-infected patients with lipodystrophy.
DB09067Corticorelin ovine triflutateCorticorelin is indicated for use in differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushing's syndrome.
DB09099SomatostatinFor the symptomatic treatment of acute bleeding from esophageal varices. Other treatment options for long-term management of the condition may be considered if necessary, once initial control has been established.
DB09221PolaprezincPeptic ulcer disease, dyspepsia [L1308].
DB09421ProtirelinNot Available
DB09527Secretin porcineNot Available
DB11510DeslorelinNot Available
DB11653BremelanotideBremelanotide is indicated to treat premenopausal women with hypoactive sexual desire disorder that is not due to a medical or psychiatric condition, problems with the relationship, or the effects of a medication or drug.[L4894]
DB11695CarnosineNot Available
DB11700SetmelanotideNot Available
DB11724BombesinNot Available
DB11788Neuropeptide YNot Available
DB11842Angiotensin IIAngiotensin II is a vasoconstrictor indicated for increasing blood pressure in adults with septic or other distributive shock [FDA Label].
DB11975TAK-448Not Available
DB12088TT-232Not Available
DB12126BradykininNot Available
DB12495SelepressinNot Available
DB12602PentetreotideNot Available
DB12620Nerve Growth FactorNot Available
DB12738TiplimotideNot Available
DB12755Zoptarelin doxorubicinNot Available
DB12777SomatoprimNot Available
DB12822Pancreatic PolypeptideNot Available
DB13033Urocortin-2Not Available
DB13298AlsactideNot Available
DB13464OrnipressinNot Available
DB13517AngiotensinamideNot Available
DB13742ElcatoninNot Available
DB09532Secretin humanIndicated for the stimulation of: - pancreatic secretions, including bicarbonate, to aid in the diagnosis of pancreatic exocrine dysfunction [FDA Label]. - gastrin secretion to aid in the diagnosis of gastrinoma [FDA Label]. - pancreatic secretions to facilitate the identification of the ampulla of Vater and accessory papilla during endoscopic retrograde cholangiopancreatography (ERCP) [FDA Label].
DB14642LypressinNot Available
DB11835Indium In-111 pentetreotideNot Available
DB05875Sar9, Met (O2)11-Substance PInvestigated for use/treatment in acute respiratory distress syndrome (ARDS) and viral infection.
DB15217Gastric inhibitory polypeptideNot Available
DB05950Contulakin-GInvestigated for use/treatment in pain (acute or chronic).
DB11720Angiotensin 1-7Not Available
DB12631AclerastideNot Available
DB15171TirzepatideNot Available
DrugDrug NameTargetType
DB00007LeuprolideGonadotropin-releasing hormone receptortarget
DB00007LeuprolideCytochrome P450 3A4enzyme
DB00010SermorelinGrowth hormone-releasing hormone receptortarget
DB00014GoserelinLutropin-choriogonadotropic hormone receptortarget
DB00014GoserelinGonadotropin-releasing hormone receptortarget
DB00017Salmon CalcitoninCalcitonin receptortarget
DB00035DesmopressinVasopressin V1a receptortarget
DB00035DesmopressinVasopressin V1b receptortarget
DB00035DesmopressinVasopressin V2 receptortarget
DB00035DesmopressinProstaglandin G/H synthase 1enzyme
DB00035DesmopressinProstaglandin G/H synthase 2enzyme
DB00050CetrorelixLutropin-choriogonadotropic hormone receptortarget
DB00050CetrorelixGonadotropin-releasing hormone receptortarget
DB00067VasopressinVasopressin V1a receptortarget
DB00067VasopressinVasopressin V2 receptortarget
DB00067VasopressinVasopressin V1b receptortarget
DB00067VasopressinCanalicular multispecific organic anion transporter 1transporter
DB00093FelypressinVasopressin V1a receptortarget
DB00183PentagastrinGastrin/cholecystokinin type B receptortarget
DB00644GonadorelinGonadotropin-releasing hormone receptortarget
DB00644GonadorelinPutative gonadotropin-releasing hormone II receptortarget
DB00666NafarelinGonadotropin-releasing hormone receptortarget
DB00666NafarelinPutative gonadotropin-releasing hormone II receptortarget
DB00855Aminolevulinic acidDelta-aminolevulinic acid dehydratasetarget
DB00855Aminolevulinic acidSolute carrier family 15 member 1transporter
DB00855Aminolevulinic acidSolute carrier family 15 member 2transporter
DB01284TetracosactideAdrenocorticotropic hormone receptortarget
DB01285CorticotropinAdrenocorticotropic hormone receptortarget
DB01285Corticotropin3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2enzyme
DB01285Corticotropin25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialenzyme
DB01285Corticotropin1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
DB01285CorticotropinCytochrome P450 3A4enzyme
DB02638TerlipressinVasopressin V1a receptortarget
DB02638TerlipressinVasopressin V2 receptortarget
DB02638TerlipressinVasopressin V1b receptortarget
DB04894VapreotideSubstance-P receptortarget
DB04894VapreotideSomatostatin receptor type 2target
DB04894VapreotideSomatostatin receptor type 5target
DB04894VapreotideCytochrome P450 3A4enzyme
DB04899NesiritideAtrial natriuretic peptide receptor 1target
DB04899NesiritideAtrial natriuretic peptide receptor 2target
DB04899NesiritideAtrial natriuretic peptide receptor 3target
DB04931AfamelanotideMelanocyte-stimulating hormone receptortarget
DB05155CR665Kappa-type opioid receptortarget
DB05394CorticorelinDopamine beta-hydroxylaseenzyme
DB06196IcatibantB2 bradykinin receptortarget
DB06196IcatibantAminopeptidase Ntarget
DB06549LabradimilB2 bradykinin receptortarget
DB06663PasireotideSomatostatin receptor type 1target
DB06663PasireotideSomatostatin receptor type 2target
DB06663PasireotideSomatostatin receptor type 3target
DB06663PasireotideSomatostatin receptor type 5target
DB06663PasireotideCytochrome P450 3A4enzyme
DB06719BuserelinLutropin-choriogonadotropic hormone receptortarget
DB06719BuserelinGonadotropin-releasing hormone receptortarget
DB06719BuserelinCytochrome P450 19A1enzyme
DB06785GanirelixGonadotropin-releasing hormone receptortarget
DB06788HistrelinGonadotropin-releasing hormone receptortarget
DB06791LanreotideSomatostatin receptor type 2target
DB06791LanreotideSomatostatin receptor type 5target
DB06791LanreotideCytochrome P450 3A4enzyme
DB06825TriptorelinGonadotropin-releasing hormone receptortarget
DB08856DADLESolute carrier organic anion transporter family member 1B1transporter
DB08861DPDPESolute carrier organic anion transporter family member 1B3transporter
DB08869TesamorelinGrowth hormone-releasing hormone receptortarget
DB09067Corticorelin ovine triflutateCorticotropin-releasing factor receptor 1target
DB09099SomatostatinSomatostatin receptor type 1target
DB09099SomatostatinSomatostatin receptor type 2target
DB09099SomatostatinSomatostatin receptor type 3target
DB09099SomatostatinSomatostatin receptor type 4target
DB09099SomatostatinSomatostatin receptor type 5target
DB09099SomatostatinMultidrug resistance protein 1transporter
DB09099SomatostatinCytochrome P450 3A4enzyme
DB09221PolaprezincTumor necrosis factortarget
DB09221PolaprezincSuperoxide dismutase [Cu-Zn]enzyme
DB09221PolaprezincHeme oxygenase 1enzyme
DB09221PolaprezincSuperoxide dismutase [Mn], mitochondrialenzyme
DB09221PolaprezincGlutathione S-transferase theta-1enzyme
DB09221PolaprezincGlutathione peroxidase 1enzyme
DB09221PolaprezincPeroxiredoxin-5, mitochondrialenzyme
DB09221PolaprezincVascular endothelial growth factor receptor 1target
DB09221PolaprezincBeta-nerve growth factortarget
DB09221PolaprezincPlatelet-derived growth factor receptor betatarget
DB09221PolaprezincHeat shock protein HSP 90-alphatarget
DB09221PolaprezincHeat shock protein HSP 90-betatarget
DB09421ProtirelinThyrotropin Releasing Hormone Receptortarget
DB11653BremelanotideMelanocyte-stimulating hormone receptortarget
DB11653BremelanotideMelanocortin receptor 4target
DB11653BremelanotideMelanocortin receptor 3target
DB11653BremelanotideMelanocortin receptor 5target
DB11653BremelanotideAdrenocorticotropic hormone receptortarget
DB11842Angiotensin IIType-1 angiotensin II receptortarget
DB09532Secretin humanSecretin receptortarget
DB14642LypressinVasopressin V1a receptortarget
DB14642LypressinVasopressin V2 receptortarget
DB14642LypressinVasopressin V1b receptortarget
DB14642LypressinCanalicular multispecific organic anion transporter 1transporter
DB05875Sar9, Met (O2)11-Substance PCytochrome P450 19A1enzyme
DB05875Sar9, Met (O2)11-Substance PCholinesteraseenzyme
DB05875Sar9, Met (O2)11-Substance PProstaglandin G/H synthase 2enzyme
DB05950Contulakin-GVoltage-dependent N-type calcium channel subunit alpha-1Btarget