DPDPE
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- DPDPE
- DrugBank Accession Number
- DB08861
- Background
A heterodetic cyclic peptide that is a cyclic enkephalin analogue, having D-penicillaminyl residues located at positions 2 and 5, which form the heterocycle via a disulfide bond.
- Type
- Small Molecule
- Groups
- Experimental
- Structure
- Weight
- Average: 645.79
Monoisotopic: 645.229090964 - Chemical Formula
- C30H39N5O7S2
- Synonyms
- (D-Pen2,D-Pen5)-Enkephalin
- [D-Pen2-D-Pen5]-enkephaline
- 2,5-Pen-enkephalin
- cyclo-[D-Pen2,5]-enkephalin
- D-penicillamine-(2,5)-enkephalin
- L-tyrosyl-3-mercapto-D-valylglycyl-L-phenylalanyl-3-mercapto-D-valine, cyclic (2-5)-disulfide
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your software1,2-Benzodiazepine The risk or severity of adverse effects can be increased when DPDPE is combined with 1,2-Benzodiazepine. Acetazolamide The risk or severity of CNS depression can be increased when Acetazolamide is combined with DPDPE. Acetophenazine The risk or severity of hypotension and CNS depression can be increased when Acetophenazine is combined with DPDPE. Aclidinium The risk or severity of adverse effects can be increased when Aclidinium is combined with DPDPE. Agomelatine The risk or severity of CNS depression can be increased when Agomelatine is combined with DPDPE. - Food Interactions
- Not Available
Categories
- Drug Categories
- Amino Acids, Peptides, and Proteins
- Analgesics
- Central Nervous System Agents
- Central Nervous System Depressants
- Enkephalins
- Narcotics
- Nerve Tissue Proteins
- Neuropeptides
- Neurotransmitter Agents
- Opioid Peptides
- Opioids
- Peptides
- Peripheral Nervous System Agents
- Proteins
- Sensory System Agents
- Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- HB4QD9GL6F
- CAS number
- 88373-73-3
- InChI Key
- MCMMCRYPQBNCPH-WMIMKTLMSA-N
- InChI
- InChI=1S/C30H39N5O7S2/c1-29(2)23(34-25(38)20(31)14-18-10-12-19(36)13-11-18)27(40)32-16-22(37)33-21(15-17-8-6-5-7-9-17)26(39)35-24(28(41)42)30(3,4)44-43-29/h5-13,20-21,23-24,36H,14-16,31H2,1-4H3,(H,32,40)(H,33,37)(H,34,38)(H,35,39)(H,41,42)/t20-,21-,23-,24-/m0/s1
- IUPAC Name
- (4S,7S,13S)-13-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]-7-benzyl-3,3,14,14-tetramethyl-6,9,12-trioxo-1,2-dithia-5,8,11-triazacyclotetradecane-4-carboxylic acid
- SMILES
- CC1(C)SSC(C)(C)[C@@H](NC(=O)[C@@H](N)CC2=CC=C(O)C=C2)C(=O)NCC(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@H]1C(O)=O
References
- General References
- Not Available
- External Links
- KEGG Compound
- C20164
- ChemSpider
- 94592
- BindingDB
- 21008
- ChEBI
- 73356
- ChEMBL
- CHEMBL31421
- ZINC
- ZINC000029206920
- Wikipedia
- DPDPE
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.00632 mg/mL ALOGPS logP 0.59 ALOGPS logP -1 Chemaxon logS -5 ALOGPS pKa (Strongest Acidic) 3.39 Chemaxon pKa (Strongest Basic) 7.73 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 8 Chemaxon Hydrogen Donor Count 7 Chemaxon Polar Surface Area 199.95 Å2 Chemaxon Rotatable Bond Count 7 Chemaxon Refractivity 168.07 m3·mol-1 Chemaxon Polarizability 65.64 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Transporters
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Sodium-independent organic anion transmembrane transporter activity
- Specific Function
- Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotre...
- Gene Name
- SLCO1B3
- Uniprot ID
- Q9NPD5
- Uniprot Name
- Solute carrier organic anion transporter family member 1B3
- Molecular Weight
- 77402.175 Da
References
- Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. [Article]
Drug created at March 04, 2013 00:42 / Updated at June 12, 2020 16:52