Bone Density Conservation Agents

Name
Bone Density Conservation Agents
Accession Number
DBCAT000089
Description

Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS.

Drugs
DrugDrug Description
Pamidronic acidA bisphosphonate used to treat Paget's disease, to treat hypercalcemia of malignancy, and to treat osteolytic bone lesions.
Zoledronic acidA bisphosphonate used to treat malignancy associated hypercalcemia, multiple myeloma, and bone metastasis from solid tumors.
Alendronic acidA bisphosphonate drug that prevents osteoclastic bone resorption and is used for the prevention and treatment of osteoporosis.
Clodronic acidA bisphosphonate used to treat osteoporosis in postmenopausal women, hypercalcemia of malignancy, and osteolysis.
Risedronic acidA bisphosphonate used to treat osteoporosis and Paget's disease.
Etidronic acidA bisphosphonate drug that prevents osteoclastic bone resorption; used for the prevention and treatment of osteoporosis.
DenosumabA RANK ligand (RANKL) inhibitor used for the management of osteoporosis in patients at high risk for bone fractures.
Salmon calcitoninA synthetic peptide form of calcitonin used to inhibit bone resorption in the treatment of hypercalcemia, osteoporosis, and Paget's disease.
CalcitriolAn active metabolite of vitamin D that is used to treat hyperparathyroidism and is also used in dialysis patients to combat hypocalcemia.
CalcifediolAn active metabolite of vitamin D used to treat hyperparathyroidism as well as to combat hypocalcemia in dialysis patients.
ErgocalciferolA vitamin found in many supplement products.
CholecalciferolA form of Vitamin D used in the treatment of specific medical conditions such as refractory rickets, hypoparathyroidism, and familial hypophosphatemia, as well as osteoporosis and chronic kidney disease.
RaloxifeneA selective estrogen receptor modulator that is used to prevent and treat osteoporosis and reduce the risk of invasive breast cancer in high-risk postmenopausal women.
ToremifeneA first generation nonsteroidal selective estrogen receptor modulator used to treat certain breast cancers.
IbandronateA bisphosphonate used to treat osteoporosis in postmenopausal women.
ParicalcitolA vitamin D analog used to treat hyperparathyroidism associated with stage 3 or greater chronic kidney disease.
DihydrotachysterolA synthetic analog of vitamin D that does not require renal activation like vitamin D2 or Vitamin D3.
Tiludronic acidA bisphosphonate used for the treatment of Paget's disease of bone.
AlfacalcidolA vitamin D analogue used for the management of hypocalcemia, secondary hyperparathyroidism, and osteodystrophy in patients with chronic renal failure.
Incadronic acidIncadronate has been investigated in the treatment of myeloma,[A14426,A14431] leukemia, and other cancers. It has also been investigated in patients with hypercalcemia of malignancy.
TeriparatideA recombinant parathyroid hormone used for the treatment of osteoporosis.
BazedoxifeneA selective estrogen receptor modulator (SERM) used to treat moderate to severe vasomotor symptoms in menopause and osteoporosis alone or in combination with conjugated estrogens.
DoxercalciferolA synthetic vitamin D2 analog used to treat secondary hyperparathyroidism in patients with chronic kidney disease with or without therapy of dialysis.
Strontium ranelateA medication used for the management of severe osteoporosis in high-risk postmenopausal women and adult men.
Vitamin DAn ingredient found in a variety of supplements and vitamins.
Human calcitoninHuman calcitonin is indicated for the treatment of Paget's disease in the cases where the use of salmon calcitonin may provoke the generation of high-titer of antibodies. Paget's disease is...
Calcitonin porcineCalcitonin is a polypeptide hormone secreted by the parafollicular cells of the thyroid gland in mammals. It inhibits bone resorption and lowers both serum and urinary calcium concentrations. Human calcitonin...
ElcatoninNot Annotated
AbaloparatideA parathyroid hormone-related protein (PTHrP) analog used for the treatment of osteoporosis in postmenopausal women with a high risk of fracture.
EldecalcitolInvestigated for use/treatment in osteoporosis.
Nandrolone decanoateAn anabolic steroid indicated for the management of the anemia of renal insufficiency by increasing hemoglobin and red cell mass.
Drugs & Drug Targets
DrugTargetType
Pamidronic acidFarnesyl pyrophosphate synthasetarget
Pamidronic acidHydroxylapatitetarget
Pamidronic acidGeranylgeranyl pyrophosphate synthasetarget
Pamidronic acidCaspase-3target
Pamidronic acidCaspase-9target
Zoledronic acidFarnesyl pyrophosphate synthasetarget
Zoledronic acidGeranylgeranyl pyrophosphate synthasetarget
Zoledronic acidHydroxylapatitetarget
Zoledronic acidMultidrug resistance-associated protein 1transporter
Alendronic acidFarnesyl pyrophosphate synthasetarget
Alendronic acidTyrosine-protein phosphatase non-receptor type 4target
Alendronic acidReceptor-type tyrosine-protein phosphatase Starget
Alendronic acidReceptor-type tyrosine-protein phosphatase epsilontarget
Alendronic acidV-type proton ATPase catalytic subunit Atarget
Alendronic acidHydroxylapatitetarget
Clodronic acidADP/ATP translocase 2target
Clodronic acidADP/ATP translocase 1target
Clodronic acidADP/ATP translocase 3target
Clodronic acidHydroxylapatitetarget
Clodronic acidProstaglandin G/H synthase 2enzyme
Risedronic acidFarnesyl pyrophosphate synthasetarget
Risedronic acidHydroxylapatitetarget
Risedronic acidProstaglandin G/H synthase 2enzyme
Etidronic acidHydroxylapatitetarget
Etidronic acidReceptor-type tyrosine-protein phosphatase Starget
Etidronic acidV-type proton ATPase catalytic subunit Atarget
Etidronic acidADP/ATP translocase 1target
Etidronic acidADP/ATP translocase 2target
Etidronic acidADP/ATP translocase 3target
DenosumabTumor necrosis factor ligand superfamily member 11target
Salmon calcitoninCalcitonin receptortarget
CalcitriolVitamin D3 receptortarget
Calcitriol1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
CalcitriolCytochrome P450 3A4enzyme
CalcitriolHomeobox protein Hox-A10target
CalcitriolVitamin D-binding proteincarrier
Calcifediol25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialenzyme
CalcifediolVitamin D3 receptortarget
Calcifediol1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
ErgocalciferolVitamin D3 receptortarget
Ergocalciferol1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
Ergocalciferol25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialenzyme
ErgocalciferolSterol 26-hydroxylase, mitochondrialenzyme
ErgocalciferolVitamin D 25-hydroxylaseenzyme
ErgocalciferolVitamin D-binding proteincarrier
ErgocalciferolVoltage-dependent calcium channeltarget
ErgocalciferolRibulose-phosphate 3-epimeraseenzyme
ErgocalciferolCholesterol side-chain cleavage enzyme, mitochondrialenzyme
CholecalciferolVitamin D-binding proteincarrier
CholecalciferolCholesterol side-chain cleavage enzyme, mitochondrialenzyme
CholecalciferolVitamin D 25-hydroxylaseenzyme
CholecalciferolSterol 26-hydroxylase, mitochondrialenzyme
CholecalciferolCytochrome P450 2J2enzyme
CholecalciferolCytochrome P450 3A4enzyme
CholecalciferolVitamin D3 receptortarget
CholecalciferolCytochrome P450 1A1enzyme
CholecalciferolCytochrome P450 2C8enzyme
RaloxifeneEstrogen receptor alphatarget
RaloxifeneEstrogen receptor betatarget
RaloxifeneAldehyde oxidaseenzyme
RaloxifeneCytochrome P450 2C8enzyme
RaloxifeneCytochrome P450 2B6enzyme
RaloxifeneCytochrome P450 19A1enzyme
RaloxifeneCytochrome P450 3A4enzyme
RaloxifeneSerpin B9target
RaloxifeneTrefoil factor 1target
RaloxifeneUDP-glucuronosyltransferase 1-1enzyme
RaloxifeneSerum albumincarrier
RaloxifeneAlpha-1-acid glycoprotein 1carrier
RaloxifeneSolute carrier organic anion transporter family member 1B1transporter
RaloxifeneSolute carrier organic anion transporter family member 1B3transporter
RaloxifeneP-glycoprotein 1transporter
RaloxifeneATP-binding cassette sub-family G member 2transporter
RaloxifeneCanalicular multispecific organic anion transporter 1transporter
RaloxifeneCanalicular multispecific organic anion transporter 2transporter
RaloxifeneMultidrug resistance-associated protein 4transporter
RaloxifeneUDP-glucuronosyltransferase 1-10enzyme
RaloxifeneUDP-glucuronosyltransferase 1-8enzyme
ToremifeneEstrogen receptor alphatarget
ToremifeneCytochrome P450 3A4enzyme
ToremifeneP-glycoprotein 1transporter
ToremifeneCytochrome P450 1A1enzyme
ToremifeneSex hormone-binding globulintarget
IbandronateFarnesyl pyrophosphate synthasetarget
IbandronateHydroxylapatitetarget
IbandronateGeranylgeranyl pyrophosphate synthasetarget
ParicalcitolVitamin D3 receptortarget
Paricalcitol1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
ParicalcitolCytochrome P450 3A4enzyme
ParicalcitolUDP-glucuronosyltransferase 1-4enzyme
DihydrotachysterolVitamin D3 receptortarget
Tiludronic acidTyrosine-protein phosphatase non-receptor type 12target
Tiludronic acidV-ATPase Subunitstarget
Tiludronic acidHydroxylapatitetarget
Tiludronic acidAdenosine triphosphate (ATP)target
Tiludronic acidSerum albumincarrier
Tiludronic acidTyrosine-protein phosphatase non-receptor type 6target
Tiludronic acidReceptor-type tyrosine-protein phosphatase epsilontarget
AlfacalcidolVitamin D-binding proteincarrier
AlfacalcidolVitamin D3 receptortarget
Alfacalcidol25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialtarget
AlfacalcidolRetinoic acid receptor RXR-alphatarget
Incadronic acidFarnesyl pyrophosphate synthasetarget
Incadronic acidCaspase-3target
Incadronic acidCaspase-4target
Incadronic acidCaspase-7target
TeriparatideParathyroid hormone/parathyroid hormone-related peptide receptortarget
BazedoxifeneEstrogen receptor alphatarget
BazedoxifeneUDP-glucuronosyltransferase 1-4enzyme
BazedoxifeneEstrogen receptor betatarget
BazedoxifeneUDP-glucuronosyltransferase 1-8enzyme
BazedoxifeneUDP-glucuronosyltransferase 1-10enzyme
DoxercalciferolSterol 26-hydroxylase, mitochondrialenzyme
DoxercalciferolVitamin D3 receptortarget
Vitamin DVitamin D3 receptortarget
Vitamin DVitamin D-binding proteintarget
Vitamin DVitamin D 25-hydroxylaseenzyme
Vitamin D25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialenzyme
Vitamin DCytochrome P450 3A4enzyme
Human calcitoninAlpha-actinin-1target
Human calcitoninAlpha-N-acetylglucosaminidaseenzyme
Human calcitoninAminopeptidase Nenzyme
Human calcitoninPhosphoglucomutase-1enzyme
AbaloparatideParathyroid hormone/parathyroid hormone-related peptide receptortarget
EldecalcitolVitamin D3 receptortarget
Nandrolone decanoateAndrogen receptortarget
Nandrolone decanoateCytochrome P450 19A1enzyme
Nandrolone decanoateAmine oxidase [flavin-containing] Benzyme
Nandrolone decanoateAmine oxidase [flavin-containing] Aenzyme