Antiplatelet agents

Name
Antiplatelet agents
Accession Number
DBCAT000149
Description

Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.

Drugs
DrugDrug Description
EptifibatideA peptide-based antagonist for glycoprotein IIb/IIIa used in the medical management of myocardial infarction and as an adjunct to percutaneous coronary intervention.
TiclopidineA platelet aggregation inhibitor used in the prevention of conditions associated with thrombi, such as stroke and transient ischemic attacks (TIA).
TirofibanA platelet aggregation inhibitor used to prevent thrombotic events in non-ST elevated acute coronary syndrome.
DipyridamoleA phosphodiesterase inhibitor used to prevent postoperative thromboembolic events.
ClopidogrelAn antiplatelet agent used to prevent blood clots in peripheral vascular disease, coronary artery disease, and cerebrovascular disease.
Acetylsalicylic acidA salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events.
PrasugrelA P2Y12 platelet inhibitor used to reduce risk of thrombotic cardiovascular events in unstable angina or non-ST-elevation myocardial infarction (NSTEMI), and in patients with STEMI when managed with either primary or delayed PCI.
VorapaxarA platelet aggregation inhibitor used to reduce thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or peripheral arterial disease (PAD).
AbciximabA monoclonal anti-glycoprotein IIb/IIIa receptor antibody used to prevent thrombosis during percutaneous coronary intervention.
AnagrelideA platelet-reducing agent used in myeloproliferative disorders to prevent thrombotic complications.
PentoxifyllineA methylxanthine derivative used to treat intermittent claudication caused by chronic occlusive arterial disease of the limbs.
IloprostA synthetic prostacyclin analog indicated to treat pulmonary arterial hypertension (PAH).
CilostazolAn antiplatelet agent and vasodilator used for the symptomatic relief of intermittent claudication.
RidogrelUsed as an adjunctive therapy to induce thrombolysis in patients suffering acute myocardial infarction.
SevofluraneA inhalation anaesthetic agent used for induction and maintenance of general anesthesia during surgical procedures.
EpoprostenolA vasodilator and platelet aggregation inhibitor used for the management of primary pulmonary hypertension and pulmonary hypertension in patients with heart failure.
ResveratrolBeing investigated for the treatment of Herpes labialis infections (cold sores).
NimesulideFor the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old.
DefibrotideA mixture of single-stranded oligonucleotides used in the treatment of severe hepatic veno-occlusive disease with renal or pulmonary dysfunction following hematopoietic stem-cell transplantation.
BeraprostFor the treatment of pulmonary hypertension.
IbudilastFor the treatment of multiple sclerosis, asthma, and cerebrovascular disease.
AndrographolideInvestigated for use/treatment in ulcerative colitis.
CangrelorA P2Y12 platelet receptor antagonist used during percutaneous coronary intervention to reduce the risk for periprocedural myocardial infarction (MI), repeat coronary revascularization, and stent thrombosis (ST).
TranilastFor the treatment of bronchial asthma, keloid and hypertrophic scar, and allergic disorders such as asthma, allergic rhinitis and atopic dermatitis.
TriflusalTriflusal is indicated as prophylaxis of thromboembolic disorders. It has been registered in Spain and in other countries of Europe, South America and South Korea for the prevention of Stroke...
Icosapent ethylAn ethyl ester of eicosapentaenoic acid (EPA) that reduces synthesis and enhances clearance of triglycerides that is used to treat patients with severe hypertriglyceridemia.
TrapidilUsed in the treatment of chronic stable angina .
NaftopidilNaftopidil has been investigated for the treatment of Disorder of Urinary Stent.
SarpogrelateSarpogrelate has been investigated for the treatment of Diabetes Mellitus, Diabetic Nephropathy, Coronary Artery Disease, and Renal Insufficiency, Chronic.
IfetrobanIfetroban has been used in trials studying the treatment of Skin Diseases, Autoimmune Diseases, Pathologic Processes, Scleroderma, Limited, and Scleroderma, Diffuse, among others.
NitroaspirinNitroaspirin has been investigated for the treatment of Intermittent Claudication.
KetanserinKetanserin has been investigated for the treatment of Septic Shock, Severe Sepsis, and Diabetic Foot Ulcer.
IndobufenIndobufen has been used in trials studying the supportive care and prevention of Atrial Fibrillation.
ButylphthalideButylphthalide has been used in trials studying the prevention of Restenosis.
HydroxytyrosolHydroxytyrosol has been used in trials studying the prevention of Breast Cancer.
RamatrobanRamatroban has been used in trials studying the treatment of Asthma.
PicotamideNot Annotated
CloricromenNot Annotated
LinsidomineNot Annotated
BuflomedilNot Annotated
RelcovaptanNot Annotated
TicagrelorA P2Y12 platelet inhibitor used in patients with a history of myocardial infarction or with acute coronary syndrome (ACS) to prevent future myocardial infarction, stroke and cardiovascular death.
TesmilifeneIntended for the treatment of various forms of cancer.
SulfinpyrazoneA platelet inhibitory and uricosuric agent used to inhibit thrombotic and embolic processes and to manage the chronic phases of gout .
CaplacizumabA von Willebrand factor (vWF)-directed antibody fragment used to treat acquired thrombotic thrombocytopenic purpura (aTTP).
1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamineNot Available
Bisindolylmaleimide VIIINot Available
Drugs & Drug Targets
DrugTargetType
EptifibatideIntegrin beta-3target
TiclopidineP2Y purinoceptor 12target
TiclopidineCytochrome P450 2C19enzyme
TiclopidineCytochrome P450 2B6enzyme
TiclopidineCytochrome P450 2C9enzyme
TiclopidineCytochrome P450 2D6enzyme
TiclopidineMyeloperoxidaseenzyme
TiclopidineCytochrome P450 1A2enzyme
TiclopidineCytochrome P450 2C8enzyme
TiclopidineCytochrome P450 2E1enzyme
TirofibanIntegrin alpha-IIbtarget
TirofibanIntegrin beta-3target
DipyridamolecAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10Atarget
DipyridamolecGMP-specific 3',5'-cyclic phosphodiesterasetarget
DipyridamolecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
DipyridamoleAdenosine deaminasetarget
DipyridamoleMultidrug resistance-associated protein 4transporter
DipyridamoleMultidrug resistance-associated protein 5transporter
DipyridamoleP-glycoprotein 1transporter
DipyridamoleCalcipressin-1target
DipyridamoleAlpha-1-acid glycoprotein 1target
DipyridamoleSolute carrier organic anion transporter family member 1B1transporter
DipyridamoleSolute carrier organic anion transporter family member 1B3transporter
DipyridamoleSolute carrier organic anion transporter family member 2B1transporter
DipyridamoleBile salt export pumptransporter
ClopidogrelP2Y purinoceptor 12target
ClopidogrelCytochrome P450 3A4enzyme
ClopidogrelCytochrome P450 2B6enzyme
ClopidogrelCytochrome P450 3A5enzyme
ClopidogrelCytochrome P450 2C19enzyme
ClopidogrelCytochrome P450 2C9enzyme
ClopidogrelCytochrome P450 1A2enzyme
ClopidogrelCytochrome P450 2C8enzyme
ClopidogrelLiver carboxylesterase 1enzyme
ClopidogrelP-glycoprotein 1transporter
ClopidogrelSolute carrier family 22 member 1transporter
ClopidogrelSolute carrier family 22 member 2transporter
Acetylsalicylic acidProstaglandin G/H synthase 1target
Acetylsalicylic acidProstaglandin G/H synthase 2target
Acetylsalicylic acidAldo-keto reductase family 1 member C1target
Acetylsalicylic acidSolute carrier family 22 member 6transporter
Acetylsalicylic acidP-glycoprotein 1transporter
Acetylsalicylic acidCytochrome P450 2C19enzyme
Acetylsalicylic acidCytochrome P450 2C9enzyme
Acetylsalicylic acid5'-AMP-activated protein kinasetarget
Acetylsalicylic acidEndothelin-1 receptortarget
Acetylsalicylic acidCellular tumor antigen p53target
Acetylsalicylic acid78 kDa glucose-regulated proteintarget
Acetylsalicylic acidRibosomal protein S6 kinase alpha-3target
Acetylsalicylic acidNF-kappa-B inhibitor alphatarget
Acetylsalicylic acidTumor necrosis factor-inducible gene 6 proteintarget
Acetylsalicylic acidCaspase-1target
Acetylsalicylic acidCaspase-3target
Acetylsalicylic acidInhibitor of nuclear factor kappa-B kinase subunit betatarget
Acetylsalicylic acidExtracellular signal-regulated kinase (ERK)target
Acetylsalicylic acidG1/S-specific cyclin-D1target
Acetylsalicylic acidMyc proto-oncogene proteintarget
Acetylsalicylic acidProliferating cell nuclear antigentarget
Acetylsalicylic acidCyclin Atarget
Acetylsalicylic acidUDP-glucuronosyltransferase 1-6enzyme
Acetylsalicylic acidArylamine N-acetyltransferase 2enzyme
Acetylsalicylic acidSolute carrier family 22 member 8transporter
PrasugrelP2Y purinoceptor 12target
PrasugrelCocaine esteraseenzyme
PrasugrelCytochrome P450 3A4enzyme
PrasugrelCytochrome P450 2B6enzyme
PrasugrelCytochrome P450 2C9enzyme
PrasugrelCytochrome P450 2C19enzyme
PrasugrelSerum albumincarrier
VorapaxarProteinase-activated receptor 1target
VorapaxarCytochrome P450 3A4enzyme
VorapaxarCytochrome P450 2J2enzyme
VorapaxarP-glycoprotein 1transporter
AbciximabIntegrin beta-3target
AbciximabLow affinity immunoglobulin gamma Fc region receptor III-Btarget
AbciximabComplement C1r subcomponenttarget
AbciximabComplement C1q subcomponent subunit Atarget
AbciximabComplement C1q subcomponent subunit Btarget
AbciximabComplement C1q subcomponent subunit Ctarget
AbciximabLow affinity immunoglobulin gamma Fc region receptor III-Atarget
AbciximabComplement C1s subcomponenttarget
AbciximabHigh affinity immunoglobulin gamma Fc receptor Itarget
AbciximabLow affinity immunoglobulin gamma Fc region receptor II-atarget
AbciximabLow affinity immunoglobulin gamma Fc region receptor II-btarget
AbciximabLow affinity immunoglobulin gamma Fc region receptor II-ctarget
AbciximabIntegrin alpha-IIbtarget
AbciximabVitronectintarget
AnagrelidecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
AnagrelideCytochrome P450 1A2enzyme
PentoxifyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
PentoxifyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
Pentoxifylline5'-nucleotidasetarget
PentoxifyllinecGMP-specific 3',5'-cyclic phosphodiesterasetarget
PentoxifyllineAdenosine receptor A1target
PentoxifyllineAdenosine receptor A2atarget
PentoxifyllineCytochrome P450 1A2enzyme
IloprostProstacyclin receptortarget
IloprostTissue-type plasminogen activatortarget
IloprostcAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
IloprostSolute carrier organic anion transporter family member 2B1transporter
IloprostSolute carrier organic anion transporter family member 2A1transporter
IloprostSolute carrier organic anion transporter family member 3A1transporter
IloprostcAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
IloprostcAMP-specific 3',5'-cyclic phosphodiesterase 4Ctarget
IloprostcAMP-specific 3',5'-cyclic phosphodiesterase 4Dtarget
IloprostProstaglandin E2 receptor EP1 subtypetarget
IloprostProstaglandin D2 receptor 2target
CilostazolcGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
CilostazolCytochrome P450 2C19enzyme
CilostazolCytochrome P450 3A4enzyme
CilostazolCytochrome P450 3A5enzyme
CilostazolCytochrome P450 3A7enzyme
CilostazolCytochrome P450 1A2enzyme
CilostazolCytochrome P450 2D6enzyme
RidogrelThromboxane-A synthasetarget
RidogrelThromboxane A2 receptortarget
SevofluraneCalcium-transporting ATPase type 2C member 1target
SevofluraneNADH-ubiquinone oxidoreductase chain 1target
SevofluraneGlycine receptor subunit alpha-1target
SevofluraneGlutamate receptor 1target
SevofluraneGamma-aminobutyric acid receptor subunit alpha-1target
SevofluranePotassium voltage-gated channel subfamily A member 1target
SevofluraneATP synthase subunit delta, mitochondrialtarget
SevofluraneCytochrome P450 2E1enzyme
SevofluraneSerum albumincarrier
SevofluraneCytochrome P450 2A6enzyme
SevofluraneCytochrome P450 2B6enzyme
SevofluraneCytochrome P450 3A4enzyme
SevofluraneGABA-A receptor (anion channel)target
EpoprostenolP2Y purinoceptor 12target
EpoprostenolProstacyclin receptortarget
EpoprostenolProstacyclin synthasetarget
ResveratrolTransthyretincarrier
ResveratrolRibosyldihydronicotinamide dehydrogenase [quinone]target
ResveratrolProstaglandin G/H synthase 1target
ResveratrolCasein kinase II subunit alphatarget
ResveratrolProstaglandin G/H synthase 2target
ResveratrolNAD-dependent protein deacetylase sirtuin-1target
ResveratrolCytochrome P450 1A1enzyme
ResveratrolCytochrome P450 3A4enzyme
ResveratrolCytochrome P450 1A2enzyme
ResveratrolCytochrome P450 1B1enzyme
ResveratrolArachidonate 15-lipoxygenasetarget
ResveratrolArachidonate 5-lipoxygenasetarget
ResveratrolAryl hydrocarbon receptortarget
ResveratrolPhosphatidylinositol 4-kinase type 2-betatarget
ResveratrolIntegrin alpha-5target
ResveratrolIntegrin beta-3target
ResveratrolSerum albumincarrier
ResveratrolAmyloid beta A4 proteintarget
ResveratrolAlpha-synucleintarget
ResveratrolEstrogen receptor alphatarget
ResveratrolMelatonin receptor type 1Atarget
ResveratrolMelatonin receptor type 1Btarget
ResveratrolC-type lectin domain family 14 member Atarget
ResveratrolNuclear receptor subfamily 1 group I member 2target
ResveratrolNuclear receptor subfamily 1 group I member 3target
ResveratrolSolute carrier family 2, facilitated glucose transporter member 1target
ResveratrolCarbonyl reductase [NADPH] 1target
ResveratrolPeroxisome proliferator-activated receptor alphatarget
ResveratrolPeroxisome proliferator-activated receptor gammatarget
ResveratrolRAC-alpha serine/threonine-protein kinasetarget
ResveratrolFar upstream element-binding protein 2target
ResveratrolTyrosine--tRNA ligase, cytoplasmictarget
NimesulideProstaglandin G/H synthase 2target
NimesulideGroup IIE secretory phospholipase A2target
NimesulideLactotransferrintarget
NimesulideCytochrome P450 3A4enzyme
DefibrotideAdenosine receptor A1target
DefibrotideAdenosine receptor A2atarget
DefibrotideAdenosine receptor A2btarget
BeraprostProstacyclin receptortarget
BeraprostCytochrome P450 2C8enzyme
IbudilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
IbudilastcGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
IbudilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
IbudilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Ctarget
IbudilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Dtarget
AndrographolideTumor necrosis factortarget
AndrographolideInterleukin-1 betatarget
AndrographolideInterleukin-6target
AndrographolideNuclear factor NF-kappa-B p100 subunittarget
AndrographolideNuclear factor NF-kappa-B p105 subunittarget
CangrelorP2Y purinoceptor 12target
TranilastHematopoietic prostaglandin D synthasetarget
TranilastCytochrome P450 3A4enzyme
TranilastCytochrome P450 2C9enzyme
TriflusalProstaglandin G/H synthase 1target
TriflusalNuclear factor NF-kappa-B p105 subunittarget
TriflusalNitric oxide synthase, inducibletarget
TriflusalcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10Atarget
TriflusalSerum albumincarrier
TrapidilPlatelet-derived growth factor receptor betatarget
TrapidilCyclic nucleotide phosphodiesterasetarget
NaftopidilCytochrome P450 3A4enzyme
Sarpogrelate5-hydroxytryptamine receptor 2Ctarget
Sarpogrelate5-hydroxytryptamine receptor 2Atarget
NitroaspirinProstaglandin G/H synthase 1target
Ketanserin5-hydroxytryptamine receptor 2Atarget
RamatrobanProstaglandin D2 receptor 2target
RelcovaptanOxytocin receptortarget
RelcovaptanVasopressin V1a receptortarget
TicagrelorCytochrome P450 3A4enzyme
TicagrelorP2Y purinoceptor 12target
TicagrelorP-glycoprotein 1transporter
TicagrelorCytochrome P450 2D6enzyme
TicagrelorCytochrome P450 2C9enzyme
TesmilifeneP-glycoprotein 1target
TesmilifeneHistamine H1 receptortarget
TesmilifeneCytochrome P450 3A4enzyme
TesmilifeneCytochrome P450 2D6enzyme
TesmilifeneCytochrome P450 1A1enzyme
SulfinpyrazoneMultidrug resistance-associated protein 1target
SulfinpyrazoneCanalicular multispecific organic anion transporter 1target
SulfinpyrazoneFatty acid-binding protein, intestinalcarrier
SulfinpyrazoneCytochrome P450 2C9enzyme
SulfinpyrazoneCanalicular multispecific organic anion transporter 2transporter
SulfinpyrazoneMultidrug resistance-associated protein 4transporter
SulfinpyrazoneMultidrug resistance-associated protein 5transporter
SulfinpyrazoneMultidrug resistance-associated protein 6transporter
SulfinpyrazoneMultidrug resistance-associated protein 1transporter
SulfinpyrazoneCanalicular multispecific organic anion transporter 1transporter
SulfinpyrazoneCytochrome P450 3A4enzyme
SulfinpyrazoneCytochrome P450 2B6enzyme
SulfinpyrazoneCytochrome P450 2C8enzyme
SulfinpyrazoneSolute carrier family 22 member 12target
SulfinpyrazoneNuclear receptor subfamily 1 group I member 2target
SulfinpyrazoneBile salt export pumptransporter
Caplacizumabvon Willebrand factortarget
1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamineRhodopsintarget
Bisindolylmaleimide VIII3-phosphoinositide-dependent protein kinase 1target
Bisindolylmaleimide VIIIMyotonin-protein kinasetarget