Platelet Aggregation Inhibitors

Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
DrugDrug NameDrug Indication
DB00063EptifibatideFor treatment of myocardial infarction and acute coronary syndrome.
DB00208TiclopidineUsed in patients, who have had a stroke or stroke precursors and who cannot take aspirin or aspirin has not worked, to try to prevent another thrombotic stroke.
DB00775TirofibanFor treatment, in combination with heparin, of acute coronary syndrome, including patients who are to be managed medically and those undergoing PTCA or atherectomy.
DB00975DipyridamoleFor as an adjunct to coumarin anticoagulants in the prevention of postoperative thromboembolic complications of cardiac valve replacement and also used in prevention of angina.
DB00758ClopidogrelFor the reduction of atherosclerotic events (myocardial infarction, stroke, and vascular death) in patients with atherosclerosis documented by recent stroke, recent myocardial infarction, or established peripheral arterial disease.
DB00945Acetylsalicylic acidFor use in the temporary relief of various forms of pain, inflammation associated with various conditions (including rheumatoid arthritis, juvenile rheumatoid arthritis, systemic lupus erythematosus, osteoarthritis, and ankylosing spondylitis), and is also used to reduce the risk of death and/or nonfatal myocardial infarction in patients with a previous infarction or unstable angina pectoris.
DB06209PrasugrelIndicated in combination with acetylsalicylic acid (ASA) to prevent atherothrombotic events in patients with acute coronary syndrome (ACS) who are to be managed with percutaneous coronary intervention (PCI). May be used in patients with unstable angina (UA), non-ST elevation myocardial infarction (NSTEMI), ST-elevation myocardial infarction (STEMI) who are to be managed with PCI. Prasugrel is not recommended in patients 75 years of age or greater, those that weigh<60kg, and patients with a history of stroke or transient ischemic attack due to increased risk of fatal and intracranial bleeding.
DB09030VorapaxarVorapaxar is indicated for the reduction of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or peripheral arterial disease (PAD). It is usually co-administered with acetylsalicylic acid (ASA) and/or clopidogrel, and should therefore be administered as an addition to these medications as it has not been studied alone.
DB00054AbciximabAbciximab is indicated as an adjunct to percutaneous coronary intervention for the prevention of cardiac ischemic complications in patients undergoing percutaneous coronary intervention and in patients with unstable angina not responding to conventional medical therapy when percutaneous coronary intervention is planned within 24 hours. Abciximab is intended for use with aspirin and heparin and has been studied only in that setting.
DB00235MilrinoneIndicated for the treatment of congestive heart failure.
DB00261AnagrelideFor the treatment of patients with thrombocythemia, secondary to myeloproliferative disorders, to reduce the elevated platelet count and the risk of thrombosis and to ameliorate associated symptoms including thrombo-hemorrhagic events.
DB00278ArgatrobanArgatroban is indicated for prevention and treatment of thrombosis caused by heparin induced thrombocytopenia (HIT). It is also indicated for use in patients with, or at risk for, HIT who are undergoing percutaneous coronary intervention.
DB00751EpinastineFor the prevention of itching associated with allergic conjunctivitis.
DB00770AlprostadilFor palliative, not definitive, therapy to temporarily maintain the patency of the ductus arteriosus until corrective or palliative surgery can be performed in neonates who have congenital heart defects and who depend upon the patent ductus for survival. Also for the treatment of erectile dysfunction due to neurogenic, vasculogenic, psychogenic, or mixed etiology.
DB00806PentoxifyllineFor the treatment of patients with intermittent lameness or immobility arising from chronic occlusive arterial disease of the limbs.
DB00972AzelastineFor the symptomatic treatment of seasonal allergic rhinitis and non-allergic rhinitis, as well as symptomatic relief of ocular itching associated with allergic conjunctivitis.
DB01088IloprostUsed for the treatment of pulmonary arterial hypertension.
DB01166CilostazolFor the reduction of symptoms of intermittent claudication (pain in the legs that occurs with walking and disappears with rest).
DB01207RidogrelUsed as an adjunctive therapy to induce thrombolysis in patients suffering acute myocardial infarction.
DB01236SevofluraneUsed for induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery.
DB01240EpoprostenolFor the long-term intravenous treatment of primary pulmonary hypertension and pulmonary hypertension associated with the scleroderma spectrum of disease in NYHA Class III and Class IV patients who do not respond adequately to conventional therapy.
DB02709ResveratrolBeing investigated for the treatment of Herpes labialis infections (cold sores).
DB04743NimesulideFor the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old.
DB04905TesmilifeneIntended for the treatment of various forms of cancer.
DB04932DefibrotideDefibrotide is used to treat or prevent a failure of normal blood flow (occlusive venous disease, OVD) in the liver of patients who have had bone marrow transplants or received certain drugs such as oral estrogens, mercaptopurine, and many others.
DB05073SRT501Investigated for use/treatment in diabetes mellitus type 2 and neurologic disorders.
DB05229BeraprostFor the treatment of pulmonary hypertension.
DB05266IbudilastFor the treatment of multiple sclerosis, asthma, and cerebrovascular disease.
DB05767AndrographolideInvestigated for use/treatment in ulcerative colitis.
DB06441CangrelorFor use as an adjunct to percutaneous coronary intervention (PCI) for reducing the risk of periprocedural myocardial infarction (MI), repeat coronary revascularization, and stent thrombosis (ST) in patients in who have not been treated with a P2Y12 platelet inhibitor and are not being given a glycoprotein IIb/IIIa inhibitor.
DB07615TranilastFor the treatment of bronchial asthma, keloid and hypertrophic scar, and allergic disorders such as asthma, allergic rhinitis and atopic dermatitis.
DB08814TriflusalFor the pevention of cardiovascular events such as stroke, for acute treatment of cerebral infarction, myocardial infarction, and for thromboprophylaxis due to atrial fibrillation.
DB08887Icosapent ethylIcosapent ethyl is used as adjunct therapy to reduce triglyceride (TG) levels in adults with severe (>500 mg/dL) hypertriglyceridemia.
DB08954IfenprodilNot Available
DB09283TrapidilUsed in the treatment of chronic stable angina [A19770].
DB12092NaftopidilNot Available
DB12163SarpogrelateNot Available
DB12177EplivanserinNot Available
DB12321IfetrobanNot Available
DB12445NitroaspirinNot Available
DB12465KetanserinNot Available
DB12545IndobufenNot Available
DB12749ButylphthalideNot Available
DB12771HydroxytyrosolNot Available
DB13036RamatrobanNot Available
DB08816TicagrelorFor the prevention of thrombotic events (for example stroke or heart attack) in patients with acute coronary syndrome or myocardial infarction with ST elevation.
DrugDrug NameTargetType
DB00063EptifibatideIntegrin beta-3target
DB00208TiclopidineP2Y purinoceptor 12target
DB00208TiclopidineCytochrome P450 3A4enzyme
DB00208TiclopidineCytochrome P450 2C19enzyme
DB00208TiclopidineCytochrome P450 2B6enzyme
DB00208TiclopidineCytochrome P450 2C9enzyme
DB00208TiclopidineCytochrome P450 2D6enzyme
DB00208TiclopidineMyeloperoxidaseenzyme
DB00208TiclopidineCytochrome P450 1A1enzyme
DB00208TiclopidineCytochrome P450 1A2enzyme
DB00208TiclopidineCytochrome P450 2C8enzyme
DB00208TiclopidineCytochrome P450 2E1enzyme
DB00775TirofibanIntegrin alpha-IIbtarget
DB00775TirofibanIntegrin beta-3target
DB00975DipyridamolecAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10Atarget
DB00975DipyridamolecGMP-specific 3',5'-cyclic phosphodiesterasetarget
DB00975DipyridamolecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
DB00975DipyridamoleAdenosine deaminasetarget
DB00975DipyridamoleMultidrug resistance-associated protein 4transporter
DB00975DipyridamoleMultidrug resistance-associated protein 5transporter
DB00975DipyridamoleMultidrug resistance protein 1transporter
DB00975DipyridamoleCalcipressin-1target
DB00975DipyridamoleAlpha-1-acid glycoprotein 1target
DB00758ClopidogrelP2Y purinoceptor 12target
DB00758ClopidogrelCytochrome P450 3A4enzyme
DB00758ClopidogrelCytochrome P450 2B6enzyme
DB00758ClopidogrelCytochrome P450 3A5enzyme
DB00758ClopidogrelCytochrome P450 2C19enzyme
DB00758ClopidogrelCytochrome P450 2C9enzyme
DB00758ClopidogrelCytochrome P450 1A2enzyme
DB00758ClopidogrelCytochrome P450 2C8enzyme
DB00758ClopidogrelLiver carboxylesterase 1enzyme
DB00758ClopidogrelMultidrug resistance protein 1transporter
DB00945Acetylsalicylic acidProstaglandin G/H synthase 1target
DB00945Acetylsalicylic acidProstaglandin G/H synthase 2target
DB00945Acetylsalicylic acidSerum albumincarrier
DB00945Acetylsalicylic acidAldo-keto reductase family 1 member C1target
DB00945Acetylsalicylic acidSolute carrier family 22 member 6transporter
DB00945Acetylsalicylic acidMultidrug resistance protein 1transporter
DB00945Acetylsalicylic acidSolute carrier family 22 member 7transporter
DB00945Acetylsalicylic acidCytochrome P450 2C19enzyme
DB00945Acetylsalicylic acidCytochrome P450 2C8enzyme
DB00945Acetylsalicylic acidCytochrome P450 2C9enzyme
DB00945Acetylsalicylic acid5'-AMP-activated protein kinasetarget
DB00945Acetylsalicylic acidEndothelin-1 receptortarget
DB00945Acetylsalicylic acidInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB00945Acetylsalicylic acidCellular tumor antigen p53target
DB00945Acetylsalicylic acid78 kDa glucose-regulated proteintarget
DB00945Acetylsalicylic acidRibosomal protein S6 kinase alpha-3target
DB00945Acetylsalicylic acidNF-kappa-B inhibitor alphatarget
DB00945Acetylsalicylic acidNuclear factor NF-kappa-Btarget
DB06209PrasugrelP2Y purinoceptor 12target
DB06209PrasugrelCocaine esteraseenzyme
DB06209PrasugrelCytochrome P450 3A4enzyme
DB06209PrasugrelCytochrome P450 2B6enzyme
DB06209PrasugrelCytochrome P450 2C9enzyme
DB06209PrasugrelCytochrome P450 2C19enzyme
DB06209PrasugrelSerum albumincarrier
DB09030VorapaxarProteinase-activated receptor 1target
DB00054AbciximabIntegrin beta-3target
DB00054AbciximabLow affinity immunoglobulin gamma Fc region receptor III-Btarget
DB00054AbciximabComplement C1r subcomponenttarget
DB00054AbciximabComplement C1q subcomponent subunit Atarget
DB00054AbciximabComplement C1q subcomponent subunit Btarget
DB00054AbciximabComplement C1q subcomponent subunit Ctarget
DB00054AbciximabLow affinity immunoglobulin gamma Fc region receptor III-Atarget
DB00054AbciximabComplement C1s subcomponenttarget
DB00054AbciximabHigh affinity immunoglobulin gamma Fc receptor Itarget
DB00054AbciximabLow affinity immunoglobulin gamma Fc region receptor II-atarget
DB00054AbciximabLow affinity immunoglobulin gamma Fc region receptor II-btarget
DB00054AbciximabLow affinity immunoglobulin gamma Fc region receptor II-ctarget
DB00054AbciximabIntegrin alpha-IIbtarget
DB00054AbciximabVitronectintarget
DB00235MilrinonecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
DB00261AnagrelidecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
DB00261AnagrelideCytochrome P450 1A2enzyme
DB00278ArgatrobanProthrombintarget
DB00278ArgatrobanCytochrome P450 3A4enzyme
DB00278ArgatrobanCytochrome P450 3A5enzyme
DB00751EpinastineHistamine H1 receptortarget
DB00751EpinastineHistamine H2 receptortarget
DB00751EpinastineAlpha-1A adrenergic receptortarget
DB00751EpinastineAlpha-2A adrenergic receptortarget
DB00751Epinastine5-hydroxytryptamine receptor 2Atarget
DB00751Epinastine5-hydroxytryptamine receptor 7target
DB00751EpinastineMultidrug resistance protein 1transporter
DB00751EpinastineCytochrome P450 2B6enzyme
DB00751EpinastineCytochrome P450 2D6enzyme
DB00751EpinastineCytochrome P450 3A4enzyme
DB00770AlprostadilProstaglandin E2 receptor EP2 subtypetarget
DB00770AlprostadilProstaglandin E2 receptor EP1 subtypetarget
DB00770AlprostadilMultidrug resistance-associated protein 5transporter
DB00770AlprostadilSolute carrier organic anion transporter family member 2B1transporter
DB00770AlprostadilSolute carrier organic anion transporter family member 3A1transporter
DB00770AlprostadilMultidrug resistance-associated protein 4transporter
DB00770AlprostadilSolute carrier organic anion transporter family member 2A1transporter
DB00770AlprostadilProstaglandin D2 receptor 2target
DB00806PentoxifyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
DB00806PentoxifyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
DB00806Pentoxifylline5'-nucleotidasetarget
DB00806PentoxifyllinecGMP-specific 3',5'-cyclic phosphodiesterasetarget
DB00806PentoxifyllineAdenosine receptor A1target
DB00806PentoxifyllineAdenosine receptor A2atarget
DB00806PentoxifyllineCytochrome P450 1A2enzyme
DB00972AzelastineHistamine H1 receptortarget
DB00972AzelastineCytochrome P450 1A2enzyme
DB00972AzelastineCytochrome P450 2D6enzyme
DB00972AzelastineCytochrome P450 3A4enzyme
DB00972AzelastineCytochrome P450 2C19enzyme
DB00972AzelastineCytochrome P450 1A1enzyme
DB00972AzelastineCytochrome P450 3A5enzyme
DB00972AzelastineCytochrome P450 2C9enzyme
DB00972AzelastineCytochrome P450 2C8enzyme
DB00972AzelastineMultidrug resistance protein 1transporter
DB00972AzelastineCytochrome P450 2A6enzyme
DB00972AzelastineCytochrome P450 2B6enzyme
DB00972AzelastineCytochrome P450 2E1enzyme
DB01088IloprostProstacyclin receptortarget
DB01088IloprostTissue-type plasminogen activatortarget
DB01088IloprostcAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
DB01088IloprostSolute carrier organic anion transporter family member 2B1transporter
DB01088IloprostSolute carrier organic anion transporter family member 2A1transporter
DB01088IloprostSolute carrier organic anion transporter family member 3A1transporter
DB01088IloprostcAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
DB01088IloprostcAMP-specific 3',5'-cyclic phosphodiesterase 4Ctarget
DB01088IloprostcAMP-specific 3',5'-cyclic phosphodiesterase 4Dtarget
DB01088IloprostProstaglandin E2 receptor EP1 subtypetarget
DB01088IloprostProstaglandin D2 receptor 2target
DB01166CilostazolcGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
DB01166CilostazolCytochrome P450 2C19enzyme
DB01166CilostazolCytochrome P450 3A4enzyme
DB01166CilostazolCytochrome P450 3A5enzyme
DB01166CilostazolCytochrome P450 3A7enzyme
DB01166CilostazolCytochrome P450 1A2enzyme
DB01166CilostazolCytochrome P450 2D6enzyme
DB01207RidogrelThromboxane-A synthasetarget
DB01207RidogrelThromboxane A2 receptortarget
DB01236SevofluraneCalcium-transporting ATPase type 2C member 1target
DB01236SevofluraneNADH-ubiquinone oxidoreductase chain 1target
DB01236SevofluraneGlycine receptor subunit alpha-1target
DB01236SevofluraneGlutamate receptor 1target
DB01236SevofluraneGamma-aminobutyric acid receptor subunit alpha-1target
DB01236SevofluranePotassium voltage-gated channel subfamily A member 1target
DB01236SevofluraneATP synthase subunit delta, mitochondrialtarget
DB01236SevofluraneCytochrome P450 2E1enzyme
DB01236SevofluraneSerum albumincarrier
DB01236SevofluraneCytochrome P450 2A6enzyme
DB01236SevofluraneCytochrome P450 2B6enzyme
DB01236SevofluraneCytochrome P450 3A4enzyme
DB01236SevofluraneGABA-A receptor (anion channel)target
DB01240EpoprostenolP2Y purinoceptor 12target
DB01240EpoprostenolProstacyclin receptortarget
DB01240EpoprostenolProstacyclin synthasetarget
DB01240EpoprostenolCytochrome P450 2C9enzyme
DB02709ResveratrolTransthyretincarrier
DB02709ResveratrolRibosyldihydronicotinamide dehydrogenase [quinone]target
DB02709ResveratrolProstaglandin G/H synthase 1target
DB02709ResveratrolCasein kinase II subunit alphatarget
DB02709ResveratrolProstaglandin G/H synthase 2target
DB02709ResveratrolCytochrome P450 1A1enzyme
DB02709ResveratrolCytochrome P450 3A4enzyme
DB02709ResveratrolCytochrome P450 1A2enzyme
DB02709ResveratrolCytochrome P450 1B1enzyme
DB02709ResveratrolArachidonate 15-lipoxygenasetarget
DB02709ResveratrolArachidonate 5-lipoxygenasetarget
DB02709ResveratrolAryl hydrocarbon receptortarget
DB02709ResveratrolPhosphatidylinositol 4-kinase type 2-betatarget
DB02709ResveratrolIntegrin alpha-5target
DB02709ResveratrolIntegrin beta-3target
DB02709ResveratrolSerum albumincarrier
DB02709ResveratrolAmyloid beta A4 proteintarget
DB02709ResveratrolAlpha-synucleintarget
DB02709ResveratrolEstrogen receptor alphatarget
DB02709ResveratrolMelatonin receptor type 1Atarget
DB02709ResveratrolMelatonin receptor type 1Btarget
DB02709ResveratrolC-type lectin domain family 14 member Atarget
DB02709ResveratrolNuclear receptor subfamily 1 group I member 2target
DB02709ResveratrolNuclear receptor subfamily 1 group I member 3target
DB02709ResveratrolSolute carrier family 2, facilitated glucose transporter member 1target
DB02709ResveratrolCarbonyl reductase [NADPH] 1target
DB02709ResveratrolPeroxisome proliferator-activated receptor alphatarget
DB02709ResveratrolPeroxisome proliferator-activated receptor gammatarget
DB02709ResveratrolRAC-alpha serine/threonine-protein kinasetarget
DB02709ResveratrolFar upstream element-binding protein 2target
DB02709ResveratrolTyrosine--tRNA ligase, cytoplasmictarget
DB04743NimesulideProstaglandin G/H synthase 2target
DB04743NimesulideGroup IIE secretory phospholipase A2target
DB04743NimesulideLactotransferrintarget
DB04905TesmilifeneMultidrug resistance protein 1target
DB04905TesmilifeneHistamine H1 receptortarget
DB04905TesmilifeneCytochrome P450 3A4enzyme
DB04905TesmilifeneCytochrome P450 2D6enzyme
DB04905TesmilifeneCytochrome P450 1A1enzyme
DB04932DefibrotideAdenosine receptor A1target
DB04932DefibrotideAdenosine receptor A2atarget
DB04932DefibrotideAdenosine receptor A2btarget
DB05073SRT501NAD-dependent protein deacetylase sirtuin-1target
DB05229BeraprostProstacyclin receptortarget
DB05229BeraprostCytochrome P450 2C8enzyme
DB05266IbudilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
DB05266IbudilastcGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
DB05266IbudilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
DB05266IbudilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Ctarget
DB05266IbudilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Dtarget
DB05767AndrographolideTumor necrosis factortarget
DB05767AndrographolideInterleukin-1 betatarget
DB05767AndrographolideInterleukin-6target
DB05767AndrographolideNuclear factor NF-kappa-B p100 subunittarget
DB05767AndrographolideNuclear factor NF-kappa-B p105 subunittarget
DB06441CangrelorP2Y purinoceptor 12target
DB07615TranilastHematopoietic prostaglandin D synthasetarget
DB08814TriflusalProstaglandin G/H synthase 1target
DB08814TriflusalNuclear factor NF-kappa-B p105 subunittarget
DB08814TriflusalNitric oxide synthase, inducibletarget
DB08814TriflusalcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10Atarget
DB08954IfenprodilGlutamate receptor ionotropic, NMDA 1target
DB08954IfenprodilGlutamate receptor ionotropic, NMDA 2Btarget
DB09283TrapidilPlatelet derived growth factor receptor betatarget
DB09283TrapidilCyclic nucleotide phosphodiesterasetarget
DB12163Sarpogrelate5-hydroxytryptamine receptor 2Ctarget
DB12163Sarpogrelate5-hydroxytryptamine receptor 2Atarget
DB12445NitroaspirinProstaglandin G/H synthase 1target
DB12465Ketanserin5-hydroxytryptamine receptor 2Atarget
DB13036RamatrobanProstaglandin D2 receptor 2target
DB08816TicagrelorCytochrome P450 3A4enzyme
DB08816TicagrelorP2Y purinoceptor 12target
DB08816TicagrelorMultidrug resistance protein 1transporter
DB08816TicagrelorCytochrome P450 2D6enzyme
DB08816TicagrelorCytochrome P450 2C9enzyme