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Identification
NameTiclopidine
Accession NumberDB00208  (APRD01257)
TypeSmall Molecule
GroupsApproved
DescriptionTiclopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who cannot take aspirin or in whom aspirin has not worked to prevent a thrombotic stroke. The FDA label includes a black-box warning of neutropenia, aplastic anemia, thrombotic thrombocytopenia purpura, and agranulocytosis, so it is necessary to monitor patients' WBC and platelets when they are taking ticlopidine.
Structure
Thumb
Synonyms
Ticlopidina
Ticlopidinum
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Alti-ticlopidine - Tab 250mgTablet250 mgOralAltimed Pharma Inc.1996-12-312005-05-27Canada
Dom-ticlopidineTablet250 mgOralDominion Pharmacal2001-05-232016-10-25Canada
Mylan-ticlopidineTablet250 mgOralMylan Pharmaceuticals Ulc1999-03-04Not applicableCanada
Nu-ticlopidine 250 mgTablet250 mgOralNu Pharm Inc1998-06-092012-09-04Canada
PMS-ticlopidineTablet250 mgOralPharmascience Inc2001-02-232016-10-28Canada
Sandoz TiclopidineTablet250 mgOralSandoz Canada Incorporated2001-05-142011-10-21Canada
Teva-ticlopidineTablet250 mgOralTeva Canada Limited2002-07-30Not applicableCanada
Ticlid 250mg TabletsTablet250 mgOralHoffmann La Roche Limited1995-12-312006-07-25Canada
Ticlid Tab 250mgTablet250 mgOralSyntex Inc.1992-12-311996-09-30Canada
TiclopidineTablet250 mgOralSanis Health Inc2010-02-162014-08-01Canada
Ticlopidine-250Tablet250 mgOralPro Doc Limitee1999-11-182010-07-13Canada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-ticlopidine TabletsTablet250 mgOralApotex Inc1998-03-30Not applicableCanada
Ticlopidine HydrochlorideTablet, film coated250 mg/1OralTeva Pharmaceuticals USA Inc1999-09-072016-02-25Us
Ticlopidine HydrochlorideTablet, film coated250 mg/1OralEon Labs, Inc.1999-08-20Not applicableUs
Ticlopidine HydrochlorideTablet, film coated250 mg/1OralCarilion Materials Management1999-09-07Not applicableUs
Ticlopidine HydrochlorideTablet, film coated250 mg/1OralCaraco Pharmaceutical Laboratories, Ltd.2002-09-26Not applicableUs
Ticlopidine HydrochlorideTablet, film coated250 mg/1OralApotex Corp.1999-07-01Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
TiclidROCHE PALO
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Ticlopidine Hydrochloride
53885-35-1
Thumb
  • InChI Key: MTKNGOHFNXIVOS-UHFFFAOYSA-N
  • Monoisotopic Mass: 299.030225589
  • Average Mass: 300.247
DBSALT000179
Categories
UNIIOM90ZUW7M1
CAS number55142-85-3
WeightAverage: 263.786
Monoisotopic: 263.05354785
Chemical FormulaC14H14ClNS
InChI KeyPHWBOXQYWZNQIN-UHFFFAOYSA-N
InChI
InChI=1S/C14H14ClNS/c15-13-4-2-1-3-11(13)9-16-7-5-14-12(10-16)6-8-17-14/h1-4,6,8H,5,7,9-10H2
IUPAC Name
5-[(2-chlorophenyl)methyl]-4H,5H,6H,7H-thieno[3,2-c]pyridine
SMILES
ClC1=CC=CC=C1CN1CCC2=C(C1)C=CS2
Pharmacology
IndicationUsed in patients, who have had a stroke or stroke precursors and who cannot take aspirin or aspirin has not worked, to try to prevent another thrombotic stroke.
Structured Indications
PharmacodynamicsTiclopidine is a prodrug that is metabolised to an as yet undetermined metabolite that acts as a platelet aggregation inhibitor. Inhibition of platelet aggregation causes a prolongation of bleeding time. In its prodrug form, ticlopidine has no significant in vitro activity at the concentrations attained in vivo.
Mechanism of actionThe active metabolite of ticlopidine prevents binding of adenosine diphosphate (ADP) to its platelet receptor, impairing the ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. It is proposed that the inhibition involves a defect in the mobilization from the storage sites of the platelet granules to the outer membrane. No direct interference occurs with the GPIIb/IIIa receptor. As the glycoprotein GPIIb/IIIa complex is the major receptor for fibrinogen, its impaired activation prevents fibrinogen binding to platelets and inhibits platelet aggregation. By blocking the amplification of platelet activation by released ADP, platelet aggregation induced by agonists other than ADP is also inhibited by the active metabolite of ticlopidine.
TargetKindPharmacological actionActionsOrganismUniProt ID
P2Y purinoceptor 12Proteinyes
antagonist
HumanQ9H244 details
Related Articles
AbsorptionAbsorption is greater than 80%. Food increases absorption by approximately 20%.
Volume of distribution

The volume of distribution was not quantified.

Protein bindingBinds reversibly (98%) to plasma proteins, mainly to serum albumin and lipoproteins. The binding to albumin and lipoproteins is nonsaturable over a wide concentration range. Ticlopidine also binds to alpha-1 acid glycoprotein (about 15% or less).
Metabolism

Ticlopidine is metabolized extensively by the liver with only trace amounts of intact drug detected. At least 20 metabolites have been identified.

SubstrateEnzymesProduct
Ticlopidine
2-ChloroticlopidineDetails
Ticlopidine
2-OxoticlopidineDetails
Ticlopidine
ThienodihydropyridiniumDetails
Ticlopidine
Ticlopidine S-oxideDetails
Ticlopidine
Dehydrogenated ticlopidineDetails
Ticlopidine
Ticlopidine N-oxideDetails
Ticlopidine
di-HydroxyticlopidineDetails
Ticlopidine
Not Available
7-HydroxyticlopidineDetails
2-Oxoticlopidine
Not Available
Active metabolite of TiclopidineDetails
Ticlopidine S-oxide
Not Available
Ticlopidine S-oxide dimerDetails
Thienodihydropyridinium
ThienopyridiniumDetails
Thienodihydropyridinium
Ticlopidine lactam analog (M8)Details
Route of eliminationTiclopidine is eliminated mostly in the urine (60%) and somewhat in the feces (23%).
Half lifeHalf-life following a single 250-mg dose is approximately 7.9 hours in subjects 20 to 43 years of age and 12.6 hours in subjects 65 to 76 years of age. With repeated dosing (250 mg twice a day), half-life is about 4 days in subjects 20 to 43 years of age and about 5 days in subjects 65 to 76 years of age.
Clearance

Ticlopidine clearance was not quantified, but clearance decreases with age.

ToxicitySingle oral doses of ticlopidine at 1600 mg/kg and 500 mg/kg were lethal to rats and mice, respectively. Symptoms of acute toxicity were GI hemorrhage, convulsions, hypothermia, dyspnea, loss of equilibrium and abnormal gait. The FDA label includes a black-box warning of neutropenia, aplastic anemia, thrombotic thrombocytopenia purpura, and agranulocytosis, so it is necessary to monitor patients' WBC and platelets when they are taking ticlopidine.
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Ticlopidine Metabolism PathwayDrug metabolismSMP00611
Ticlopidine Action PathwayDrug actionSMP00261
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
4-MethoxyamphetamineThe metabolism of 4-Methoxyamphetamine can be decreased when combined with Ticlopidine.Experimental, Illicit
AbciximabTiclopidine may increase the anticoagulant activities of Abciximab.Approved
AbirateroneThe serum concentration of Ticlopidine can be increased when it is combined with Abiraterone.Approved
AceclofenacThe metabolism of Aceclofenac can be decreased when combined with Ticlopidine.Approved
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Ticlopidine.Approved
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Ticlopidine.Approved
AcetylcholineThe metabolism of Acetylcholine can be decreased when combined with Ticlopidine.Approved
Acetylsalicylic acidThe risk or severity of adverse effects can be increased when Ticlopidine is combined with Acetylsalicylic acid.Approved, Vet Approved
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Ticlopidine.Approved
AgomelatineThe serum concentration of Agomelatine can be increased when it is combined with Ticlopidine.Approved, Investigational
AjmalineThe metabolism of Ajmaline can be decreased when combined with Ticlopidine.Approved
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Ticlopidine.Approved, Vet Approved
AlclometasoneThe metabolism of Alclometasone can be decreased when combined with Ticlopidine.Approved
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Ticlopidine.Approved, Illicit
AlfuzosinThe metabolism of Alfuzosin can be decreased when combined with Ticlopidine.Approved, Investigational
AliskirenThe metabolism of Aliskiren can be decreased when combined with Ticlopidine.Approved, Investigational
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Ticlopidine.Approved
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Ticlopidine.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Ticlopidine.Approved
AlosetronThe metabolism of Alosetron can be decreased when combined with Ticlopidine.Approved, Withdrawn
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Ticlopidine.Approved, Illicit, Investigational
AlprenololThe metabolism of Alprenolol can be decreased when combined with Ticlopidine.Approved, Withdrawn
AlprostadilAlprostadil may increase the anticoagulant activities of Ticlopidine.Approved, Investigational
AlteplaseTiclopidine may increase the anticoagulant activities of Alteplase.Approved
ALX-0081Ticlopidine may increase the anticoagulant activities of ALX-0081.Investigational
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Ticlopidine.Approved, Investigational
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Ticlopidine.Approved
Ambroxol acefyllinateThe metabolism of Ambroxol acefyllinate can be decreased when combined with Ticlopidine.Experimental
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Ticlopidine.Approved, Withdrawn
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Ticlopidine.Approved
Aminosalicylic AcidThe risk or severity of adverse effects can be increased when Ticlopidine is combined with Aminosalicylic Acid.Approved
AmiodaroneThe metabolism of Ticlopidine can be decreased when combined with Amiodarone.Approved, Investigational
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Ticlopidine.Approved
AmlodipineThe metabolism of Amlodipine can be decreased when combined with Ticlopidine.Approved
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Ticlopidine.Approved
AmoxapineThe metabolism of Amoxapine can be decreased when combined with Ticlopidine.Approved
AmoxicillinThe metabolism of Amoxicillin can be decreased when combined with Ticlopidine.Approved, Vet Approved
AmphetamineThe metabolism of Amphetamine can be decreased when combined with Ticlopidine.Approved, Illicit
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Ticlopidine.Approved
AmsacrineThe metabolism of Amsacrine can be decreased when combined with Ticlopidine.Approved
AnagrelideThe metabolism of Anagrelide can be decreased when combined with Ticlopidine.Approved
AncrodTiclopidine may increase the anticoagulant activities of Ancrod.Investigational
AnilineThe metabolism of Aniline can be decreased when combined with Ticlopidine.Experimental
AnistreplaseTiclopidine may increase the anticoagulant activities of Anistreplase.Approved
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Ticlopidine.Approved
Antithrombin III humanTiclopidine may increase the anticoagulant activities of Antithrombin III human.Approved
ApixabanThe risk or severity of adverse effects can be increased when Ticlopidine is combined with Apixaban.Approved
ApremilastThe metabolism of Apremilast can be decreased when combined with Ticlopidine.Approved, Investigational
AprepitantThe serum concentration of Ticlopidine can be increased when it is combined with Aprepitant.Approved, Investigational
AprindineThe metabolism of Aprindine can be decreased when combined with Ticlopidine.Approved
AprotininThe therapeutic efficacy of Ticlopidine can be decreased when used in combination with Aprotinin.Approved, Withdrawn
Arachidonic AcidThe metabolism of Arachidonic Acid can be decreased when combined with Ticlopidine.Experimental
ArdeparinTiclopidine may increase the anticoagulant activities of Ardeparin.Approved, Withdrawn
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Ticlopidine.Approved, Investigational
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Ticlopidine.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Ticlopidine.Approved, Investigational
ArmodafinilThe metabolism of Ticlopidine can be decreased when combined with Armodafinil.Approved, Investigational
ArtemetherThe metabolism of Artemether can be decreased when combined with Ticlopidine.Approved
ASA404The metabolism of ASA404 can be decreased when combined with Ticlopidine.Investigational
AsenapineThe metabolism of Asenapine can be decreased when combined with Ticlopidine.Approved
AstaxanthinTiclopidine may increase the anticoagulant activities of Astaxanthin.Investigational
AstemizoleThe metabolism of Astemizole can be decreased when combined with Ticlopidine.Approved, Withdrawn
AtazanavirThe metabolism of Ticlopidine can be decreased when combined with Atazanavir.Approved, Investigational
AtomoxetineThe metabolism of Atomoxetine can be decreased when combined with Ticlopidine.Approved
AtorvastatinThe metabolism of Atorvastatin can be decreased when combined with Ticlopidine.Approved
AV650The metabolism of AV650 can be decreased when combined with Ticlopidine.Approved, Investigational
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Ticlopidine.Approved
AxitinibThe metabolism of Axitinib can be decreased when combined with Ticlopidine.Approved, Investigational
AzelastineThe metabolism of Azelastine can be decreased when combined with Ticlopidine.Approved
AzithromycinThe metabolism of Azithromycin can be decreased when combined with Ticlopidine.Approved
BalsalazideThe risk or severity of adverse effects can be increased when Ticlopidine is combined with Balsalazide.Approved, Investigational
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Ticlopidine.Investigational
BatroxobinTiclopidine may increase the anticoagulant activities of Batroxobin.Experimental
BecaplerminTiclopidine may increase the anticoagulant activities of Becaplermin.Approved, Investigational
BedaquilineThe metabolism of Bedaquiline can be decreased when combined with Ticlopidine.Approved
BemiparinTiclopidine may increase the anticoagulant activities of Bemiparin.Approved
BendamustineThe metabolism of Bendamustine can be decreased when combined with Ticlopidine.Approved, Investigational
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Ticlopidine.Approved
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Ticlopidine.Approved, Illicit
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Ticlopidine.Approved
BepridilThe metabolism of Bepridil can be decreased when combined with Ticlopidine.Approved, Withdrawn
BeraprostTiclopidine may increase the anticoagulant activities of Beraprost.Investigational
BetaxololThe metabolism of Betaxolol can be decreased when combined with Ticlopidine.Approved
BexaroteneThe serum concentration of Ticlopidine can be decreased when it is combined with Bexarotene.Approved, Investigational
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Ticlopidine.Approved
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Ticlopidine.Approved
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Ticlopidine.Approved
BivalirudinTiclopidine may increase the anticoagulant activities of Bivalirudin.Approved, Investigational
BoceprevirThe metabolism of Ticlopidine can be decreased when combined with Boceprevir.Approved
BortezomibThe metabolism of Bortezomib can be decreased when combined with Ticlopidine.Approved, Investigational
BosentanThe serum concentration of Bosentan can be increased when it is combined with Ticlopidine.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Ticlopidine.Approved
Brentuximab vedotinThe metabolism of Brentuximab vedotin can be decreased when combined with Ticlopidine.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Ticlopidine.Approved
BrinzolamideThe metabolism of Brinzolamide can be decreased when combined with Ticlopidine.Approved
BromazepamThe metabolism of Bromazepam can be decreased when combined with Ticlopidine.Approved, Illicit
BromocriptineThe metabolism of Bromocriptine can be decreased when combined with Ticlopidine.Approved, Investigational
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Ticlopidine.Approved
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Ticlopidine.Approved
BudesonideThe metabolism of Budesonide can be decreased when combined with Ticlopidine.Approved
BufuralolThe metabolism of Bufuralol can be decreased when combined with Ticlopidine.Experimental, Investigational
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Ticlopidine.Approved, Investigational
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Ticlopidine.Approved, Illicit, Investigational, Vet Approved
BupropionThe serum concentration of Bupropion can be increased when it is combined with Ticlopidine.Approved
BuspironeThe metabolism of Buspirone can be decreased when combined with Ticlopidine.Approved, Investigational
BusulfanThe metabolism of Busulfan can be decreased when combined with Ticlopidine.Approved, Investigational
ButylphthalideButylphthalide may increase the anticoagulant activities of Ticlopidine.Investigational
CabazitaxelThe metabolism of Cabazitaxel can be decreased when combined with Ticlopidine.Approved
CabergolineThe metabolism of Cabergoline can be decreased when combined with Ticlopidine.Approved
CabozantinibThe metabolism of Cabozantinib can be decreased when combined with Ticlopidine.Approved
CaffeineThe metabolism of Caffeine can be decreased when combined with Ticlopidine.Approved
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Ticlopidine.Approved, Nutraceutical
CanagliflozinThe metabolism of Canagliflozin can be decreased when combined with Ticlopidine.Approved
CandesartanThe metabolism of Candesartan can be decreased when combined with Ticlopidine.Approved
CangrelorTiclopidine may increase the anticoagulant activities of Cangrelor.Approved
CapsaicinThe metabolism of Capsaicin can be decreased when combined with Ticlopidine.Approved
CaptoprilThe metabolism of Captopril can be decreased when combined with Ticlopidine.Approved
CarbamazepineThe metabolism of Ticlopidine can be increased when combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Ticlopidine.Approved
CariprazineThe metabolism of Cariprazine can be decreased when combined with Ticlopidine.Approved
CarisoprodolThe metabolism of Carisoprodol can be decreased when combined with Ticlopidine.Approved
CarmustineThe metabolism of Carmustine can be decreased when combined with Ticlopidine.Approved
CarteololThe metabolism of Carteolol can be decreased when combined with Ticlopidine.Approved
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Ticlopidine.Approved, Investigational
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Ticlopidine.Approved, Investigational
CeliprololThe metabolism of Celiprolol can be decreased when combined with Ticlopidine.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be decreased when combined with Ticlopidine.Approved, Vet Approved
CeritinibThe serum concentration of Ticlopidine can be increased when it is combined with Ceritinib.Approved
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Ticlopidine.Withdrawn
CertoparinTiclopidine may increase the anticoagulant activities of Certoparin.Approved
CevimelineThe metabolism of Cevimeline can be decreased when combined with Ticlopidine.Approved
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Ticlopidine.Approved
ChloramphenicolThe metabolism of Chloramphenicol can be decreased when combined with Ticlopidine.Approved, Vet Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Ticlopidine.Approved, Illicit
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Ticlopidine.Approved, Vet Approved
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Ticlopidine.Approved
ChlorpromazineThe metabolism of Chlorpromazine can be decreased when combined with Ticlopidine.Approved, Vet Approved
ChlorpropamideThe metabolism of Chlorpropamide can be decreased when combined with Ticlopidine.Approved
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Ticlopidine.Approved
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Ticlopidine.Approved, Nutraceutical
CiclesonideThe metabolism of Ciclesonide can be decreased when combined with Ticlopidine.Approved, Investigational
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Ticlopidine.Approved
CimetidineThe metabolism of Ticlopidine can be decreased when combined with Cimetidine.Approved
CinacalcetThe metabolism of Ticlopidine can be decreased when combined with Cinacalcet.Approved
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Ticlopidine.Approved
CisaprideThe metabolism of Cisapride can be decreased when combined with Ticlopidine.Approved, Investigational, Withdrawn
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Ticlopidine.Approved
Citric AcidTiclopidine may increase the anticoagulant activities of Citric Acid.Nutraceutical, Vet Approved
ClarithromycinThe metabolism of Ticlopidine can be decreased when combined with Clarithromycin.Approved
ClemastineThe metabolism of Ticlopidine can be decreased when combined with Clemastine.Approved
ClenbuterolThe metabolism of Clenbuterol can be decreased when combined with Ticlopidine.Approved, Vet Approved
ClevidipineThe metabolism of Clevidipine can be decreased when combined with Ticlopidine.Approved
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Ticlopidine.Approved, Vet Approved
ClobazamThe metabolism of Clobazam can be decreased when combined with Ticlopidine.Approved, Illicit
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Ticlopidine.Approved, Investigational
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Ticlopidine.Approved
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Ticlopidine.Investigational
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Ticlopidine.Approved, Vet Approved
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Ticlopidine.Approved, Illicit
ClonidineThe metabolism of Clonidine can be decreased when combined with Ticlopidine.Approved
ClopidogrelThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Ticlopidine resulting in a loss in efficacy.Approved, Nutraceutical
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Ticlopidine.Approved, Illicit
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Ticlopidine.Approved, Illicit
ClotrimazoleThe metabolism of Ticlopidine can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe metabolism of Clozapine can be decreased when combined with Ticlopidine.Approved
CobicistatThe serum concentration of Ticlopidine can be increased when it is combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Ticlopidine.Approved
CocaineThe metabolism of Ticlopidine can be decreased when combined with Cocaine.Approved, Illicit
CodeineThe therapeutic efficacy of Codeine can be decreased when used in combination with Ticlopidine.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Ticlopidine.Approved
CollagenaseThe risk or severity of adverse effects can be increased when Ticlopidine is combined with Collagenase.Approved
ConivaptanThe serum concentration of Ticlopidine can be increased when it is combined with Conivaptan.Approved, Investigational
Conjugated Equine EstrogensThe metabolism of Conjugated Equine Estrogens can be decreased when combined with Ticlopidine.Approved
Cortisone acetateThe metabolism of Cortisone acetate can be decreased when combined with Ticlopidine.Approved
CrizotinibThe metabolism of Crizotinib can be decreased when combined with Ticlopidine.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Ticlopidine.Approved
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Ticlopidine.Approved, Investigational
CyclosporineThe metabolism of Cyclosporine can be decreased when combined with Ticlopidine.Approved, Investigational, Vet Approved
CytarabineThe metabolism of Cytarabine can be decreased when combined with Ticlopidine.Approved, Investigational
Dabigatran etexilateTiclopidine may increase the anticoagulant activities of Dabigatran etexilate.Approved
DabrafenibThe serum concentration of Ticlopidine can be decreased when it is combined with Dabrafenib.Approved
DacarbazineThe metabolism of Dacarbazine can be decreased when combined with Ticlopidine.Approved, Investigational
DaclatasvirThe metabolism of Daclatasvir can be decreased when combined with Ticlopidine.Approved
DalfampridineThe metabolism of Dalfampridine can be decreased when combined with Ticlopidine.Approved
DalteparinTiclopidine may increase the anticoagulant activities of Dalteparin.Approved
DanaparoidTiclopidine may increase the anticoagulant activities of Danaparoid.Approved, Withdrawn
DantroleneThe metabolism of Dantrolene can be decreased when combined with Ticlopidine.Approved
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Ticlopidine.Approved
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Ticlopidine.Investigational
DapsoneThe metabolism of Dapsone can be decreased when combined with Ticlopidine.Approved, Investigational
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Ticlopidine.Approved, Investigational
DarunavirThe serum concentration of Ticlopidine can be increased when it is combined with Darunavir.Approved
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Ticlopidine.Approved
DasatinibDasatinib may increase the anticoagulant activities of Ticlopidine.Approved, Investigational
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Ticlopidine.Approved
DebrisoquinThe metabolism of Debrisoquin can be decreased when combined with Ticlopidine.Approved
DeferasiroxThe serum concentration of Ticlopidine can be decreased when it is combined with Deferasirox.Approved, Investigational
DefibrotideTiclopidine may increase the anticoagulant activities of Defibrotide.Approved, Investigational
DelavirdineThe metabolism of Ticlopidine can be decreased when combined with Delavirdine.Approved
Deoxycholic AcidThe risk or severity of adverse effects can be increased when Ticlopidine is combined with Deoxycholic Acid.Approved
dersalazineThe risk or severity of adverse effects can be increased when Ticlopidine is combined with dersalazine.Investigational
DesipramineThe metabolism of Desipramine can be decreased when combined with Ticlopidine.Approved
DesirudinTiclopidine may increase the anticoagulant activities of Desirudin.Approved
DesmoteplaseTiclopidine may increase the anticoagulant activities of Desmoteplase.Investigational
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Ticlopidine.Approved
DexamethasoneThe serum concentration of Ticlopidine can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Ticlopidine.Approved, Illicit, Withdrawn
DexmedetomidineThe metabolism of Dexmedetomidine can be decreased when combined with Ticlopidine.Approved, Vet Approved
DexmethylphenidateThe metabolism of Dexmethylphenidate can be decreased when combined with Ticlopidine.Approved
DextranTiclopidine may increase the anticoagulant activities of Dextran.Approved, Vet Approved
Dextran 40Ticlopidine may increase the anticoagulant activities of Dextran 40.Approved
Dextran 70Ticlopidine may increase the anticoagulant activities of Dextran 70.Approved
Dextran 75Ticlopidine may increase the anticoagulant activities of Dextran 75.Approved
DextroamphetamineThe metabolism of Dextroamphetamine can be decreased when combined with Ticlopidine.Approved, Illicit
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Ticlopidine.Approved
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Ticlopidine.Approved, Illicit, Withdrawn
DiazepamThe metabolism of Diazepam can be decreased when combined with Ticlopidine.Approved, Illicit, Vet Approved
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Ticlopidine.Approved, Vet Approved
DicoumarolThe metabolism of Dicoumarol can be decreased when combined with Ticlopidine.Approved
DiflunisalThe risk or severity of adverse effects can be increased when Ticlopidine is combined with Diflunisal.Approved
DigitoxinThe metabolism of Digitoxin can be decreased when combined with Ticlopidine.Approved
DigoxinThe metabolism of Digoxin can be decreased when combined with Ticlopidine.Approved
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Ticlopidine.Approved, Illicit
DihydroergotamineThe metabolism of Dihydroergotamine can be decreased when combined with Ticlopidine.Approved
DiltiazemThe metabolism of Diltiazem can be decreased when combined with Ticlopidine.Approved
DinoprostoneThe metabolism of Dinoprostone can be decreased when combined with Ticlopidine.Approved
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Ticlopidine.Approved
DipyridamoleTiclopidine may increase the anticoagulant activities of Dipyridamole.Approved
DisopyramideThe metabolism of Disopyramide can be decreased when combined with Ticlopidine.Approved
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Ticlopidine.Approved
DitazoleTiclopidine may increase the anticoagulant activities of Ditazole.Approved, Withdrawn
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Ticlopidine.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Ticlopidine.Approved
DolasetronThe metabolism of Dolasetron can be decreased when combined with Ticlopidine.Approved
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Ticlopidine.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be decreased when combined with Ticlopidine.Approved
DopamineThe metabolism of Dopamine can be decreased when combined with Ticlopidine.Approved
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Ticlopidine.Approved
DoxazosinThe metabolism of Doxazosin can be decreased when combined with Ticlopidine.Approved
DoxepinThe metabolism of Doxepin can be decreased when combined with Ticlopidine.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Ticlopidine.Approved, Investigational
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Ticlopidine.Approved, Investigational
DoxycyclineThe metabolism of Ticlopidine can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Ticlopidine.Approved, Illicit
DronedaroneThe metabolism of Dronedarone can be decreased when combined with Ticlopidine.Approved
Drotrecogin alfaTiclopidine may increase the anticoagulant activities of Drotrecogin alfa.Approved, Investigational, Withdrawn
DuloxetineThe metabolism of Duloxetine can be decreased when combined with Ticlopidine.Approved
DutasterideThe metabolism of Dutasteride can be decreased when combined with Ticlopidine.Approved, Investigational
DyphyllineThe metabolism of Dyphylline can be decreased when combined with Ticlopidine.Approved
Edetic AcidTiclopidine may increase the anticoagulant activities of Edetic Acid.Approved, Vet Approved
EdoxabanTiclopidine may increase the anticoagulant activities of Edoxaban.Approved
EfavirenzThe serum concentration of Ticlopidine can be decreased when it is combined with Efavirenz.Approved, Investigational
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Ticlopidine.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Ticlopidine.Approved
EltrombopagThe metabolism of Eltrombopag can be decreased when combined with Ticlopidine.Approved
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Ticlopidine.Approved
EnalaprilThe metabolism of Enalapril can be decreased when combined with Ticlopidine.Approved, Vet Approved
EncainideThe metabolism of Encainide can be decreased when combined with Ticlopidine.Approved, Withdrawn
EnclomipheneThe metabolism of Enclomiphene can be decreased when combined with Ticlopidine.Investigational
EnfluraneThe metabolism of Enflurane can be decreased when combined with Ticlopidine.Approved, Vet Approved
EnfuvirtideThe metabolism of Enfuvirtide can be decreased when combined with Ticlopidine.Approved, Investigational
EnoxaparinTiclopidine may increase the anticoagulant activities of Enoxaparin.Approved
EnzalutamideThe serum concentration of Ticlopidine can be decreased when it is combined with Enzalutamide.Approved
EpinastineThe metabolism of Epinastine can be decreased when combined with Ticlopidine.Approved, Investigational
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Ticlopidine.Approved
eplivanserineTiclopidine may increase the anticoagulant activities of eplivanserine.Investigational
EpoprostenolEpoprostenol may increase the antiplatelet activities of Ticlopidine.Approved
EptifibatideEptifibatide may increase the anticoagulant activities of Ticlopidine.Approved, Investigational
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Ticlopidine.Approved, Nutraceutical
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be decreased when combined with Ticlopidine.Approved
ErgonovineThe metabolism of Ergonovine can be decreased when combined with Ticlopidine.Approved
ErgotamineThe metabolism of Ergotamine can be decreased when combined with Ticlopidine.Approved
ErlotinibThe metabolism of Erlotinib can be decreased when combined with Ticlopidine.Approved, Investigational
ErythromycinThe metabolism of Erythromycin can be decreased when combined with Ticlopidine.Approved, Vet Approved
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Ticlopidine.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Ticlopidine can be decreased when it is combined with Eslicarbazepine acetate.Approved
EsmirtazapineThe metabolism of Esmirtazapine can be decreased when combined with Ticlopidine.Investigational
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Ticlopidine.Approved, Investigational
EstazolamThe metabolism of Estazolam can be decreased when combined with Ticlopidine.Approved, Illicit
EstradiolThe metabolism of Estradiol can be decreased when combined with Ticlopidine.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Ticlopidine.Approved
EstramustineThe metabolism of Estramustine can be decreased when combined with Ticlopidine.Approved
EstroneThe metabolism of Estrone can be decreased when combined with Ticlopidine.Approved
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Ticlopidine.Approved
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Ticlopidine.Approved
EthanolThe metabolism of Ethanol can be decreased when combined with Ticlopidine.Approved
Ethanolamine OleateThe metabolism of Ethanolamine Oleate can be decreased when combined with Ticlopidine.Approved
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be decreased when combined with Ticlopidine.Approved
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Ticlopidine.Approved
Ethyl biscoumacetateTiclopidine may increase the anticoagulant activities of Ethyl biscoumacetate.Withdrawn
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Ticlopidine.Approved, Illicit
EtodolacThe metabolism of Etodolac can be decreased when combined with Ticlopidine.Approved, Investigational, Vet Approved
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Ticlopidine.Approved, Investigational
EtoposideThe metabolism of Etoposide can be decreased when combined with Ticlopidine.Approved
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Ticlopidine.Approved, Investigational
EtravirineThe metabolism of Etravirine can be decreased when combined with Ticlopidine.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Ticlopidine.Approved
ExemestaneThe metabolism of Exemestane can be decreased when combined with Ticlopidine.Approved, Investigational
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Ticlopidine.Approved
FamotidineThe metabolism of Famotidine can be decreased when combined with Ticlopidine.Approved
FelbamateThe metabolism of Felbamate can be decreased when combined with Ticlopidine.Approved
FelodipineThe metabolism of Felodipine can be decreased when combined with Ticlopidine.Approved, Investigational
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Ticlopidine.Approved
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Ticlopidine.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Ticlopidine.Approved
FibrinolysinTiclopidine may increase the anticoagulant activities of Fibrinolysin.Approved
FinasterideThe metabolism of Finasteride can be decreased when combined with Ticlopidine.Approved
FingolimodThe metabolism of Fingolimod can be decreased when combined with Ticlopidine.Approved, Investigational
FlecainideThe metabolism of Flecainide can be decreased when combined with Ticlopidine.Approved, Withdrawn
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Ticlopidine.Approved
FluconazoleThe metabolism of Ticlopidine can be decreased when combined with Fluconazole.Approved
FluindioneTiclopidine may increase the anticoagulant activities of Fluindione.Investigational
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Ticlopidine.Approved
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Ticlopidine.Approved, Investigational
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Ticlopidine.Approved, Illicit
FluorometholoneThe metabolism of Fluorometholone can be decreased when combined with Ticlopidine.Approved
FluorouracilThe metabolism of Fluorouracil can be decreased when combined with Ticlopidine.Approved
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Ticlopidine.Approved, Vet Approved
FluphenazineThe metabolism of Fluphenazine can be decreased when combined with Ticlopidine.Approved
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Ticlopidine.Approved, Illicit
FlurbiprofenThe metabolism of Flurbiprofen can be decreased when combined with Ticlopidine.Approved, Investigational
FlutamideThe metabolism of Flutamide can be decreased when combined with Ticlopidine.Approved
Fluticasone furoateThe metabolism of Fluticasone furoate can be decreased when combined with Ticlopidine.Approved
Fluticasone PropionateThe metabolism of Fluticasone Propionate can be decreased when combined with Ticlopidine.Approved
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Ticlopidine.Approved
FluvoxamineThe metabolism of Ticlopidine can be decreased when combined with Fluvoxamine.Approved, Investigational
Folic AcidThe metabolism of Folic Acid can be decreased when combined with Ticlopidine.Approved, Nutraceutical, Vet Approved
FondaparinuxTiclopidine may increase the anticoagulant activities of Fondaparinux.Investigational
Fondaparinux sodiumTiclopidine may increase the anticoagulant activities of Fondaparinux sodium.Approved, Investigational
FormoterolThe metabolism of Formoterol can be decreased when combined with Ticlopidine.Approved, Investigational
FosamprenavirThe metabolism of Fosamprenavir can be decreased when combined with Ticlopidine.Approved
FosaprepitantThe serum concentration of Ticlopidine can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe serum concentration of Fosphenytoin can be increased when it is combined with Ticlopidine.Approved
FrovatriptanThe metabolism of Frovatriptan can be decreased when combined with Ticlopidine.Approved, Investigational
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Ticlopidine.Approved, Investigational
Fusidic AcidThe serum concentration of Ticlopidine can be increased when it is combined with Fusidic Acid.Approved
GabexateTiclopidine may increase the anticoagulant activities of Gabexate.Investigational
GalantamineThe metabolism of Galantamine can be decreased when combined with Ticlopidine.Approved
GavestinelThe metabolism of Gavestinel can be decreased when combined with Ticlopidine.Investigational
GefitinibThe metabolism of Gefitinib can be decreased when combined with Ticlopidine.Approved, Investigational
GemfibrozilThe metabolism of Ticlopidine can be decreased when combined with Gemfibrozil.Approved
GenisteinThe metabolism of Genistein can be decreased when combined with Ticlopidine.Investigational
GliclazideThe metabolism of Gliclazide can be decreased when combined with Ticlopidine.Approved
GlimepirideThe metabolism of Glimepiride can be decreased when combined with Ticlopidine.Approved
GlipizideThe metabolism of Glipizide can be decreased when combined with Ticlopidine.Approved
GlucosamineGlucosamine may increase the antiplatelet activities of Ticlopidine.Approved
GlyburideThe metabolism of Glyburide can be decreased when combined with Ticlopidine.Approved
GranisetronThe metabolism of Granisetron can be decreased when combined with Ticlopidine.Approved, Investigational
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Ticlopidine.Withdrawn
GuanabenzThe metabolism of Guanabenz can be decreased when combined with Ticlopidine.Approved
GuanfacineThe metabolism of Guanfacine can be decreased when combined with Ticlopidine.Approved, Investigational
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Ticlopidine.Approved
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Ticlopidine.Approved
HalothaneThe metabolism of Halothane can be decreased when combined with Ticlopidine.Approved, Vet Approved
HeparinTiclopidine may increase the anticoagulant activities of Heparin.Approved, Investigational
HesperetinThe metabolism of Hesperetin can be decreased when combined with Ticlopidine.Approved
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Ticlopidine.Approved
HigenamineTiclopidine may increase the anticoagulant activities of Higenamine.Investigational
HirulogTiclopidine may increase the anticoagulant activities of Hirulog.Experimental
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Ticlopidine.Approved
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Ticlopidine.Approved, Illicit
HydrocortisoneThe metabolism of Hydrocortisone can be decreased when combined with Ticlopidine.Approved, Vet Approved
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Ticlopidine.Approved, Illicit
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Ticlopidine.Approved
Ibritumomab tiuxetanThe risk or severity of adverse effects can be increased when Ticlopidine is combined with Ibritumomab tiuxetan.Approved
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Ticlopidine.Approved
IbudilastIbudilast may increase the anticoagulant activities of Ticlopidine.Approved, Investigational
IbuprofenThe metabolism of Ibuprofen can be decreased when combined with Ticlopidine.Approved
Icosapent ethylIcosapent ethyl may increase the anticoagulant activities of Ticlopidine.Approved, Nutraceutical
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Ticlopidine.Approved
IdelalisibThe serum concentration of Ticlopidine can be increased when it is combined with Idelalisib.Approved
idraparinuxTiclopidine may increase the anticoagulant activities of idraparinux.Investigational
IfenprodilIfenprodil may increase the anticoagulant activities of Ticlopidine.Approved, Withdrawn
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Ticlopidine resulting in a loss in efficacy.Approved
IloperidoneThe metabolism of Iloperidone can be decreased when combined with Ticlopidine.Approved
IloprostIloprost may increase the antiplatelet activities of Ticlopidine.Approved, Investigational
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Ticlopidine.Approved
ImipramineThe metabolism of Imipramine can be decreased when combined with Ticlopidine.Approved
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Ticlopidine.Approved, Investigational
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Ticlopidine.Approved
IndapamideThe metabolism of Indapamide can be decreased when combined with Ticlopidine.Approved
IndinavirThe metabolism of Ticlopidine can be decreased when combined with Indinavir.Approved
indisulamThe metabolism of indisulam can be decreased when combined with Ticlopidine.Investigational
IndobufenTiclopidine may increase the anticoagulant activities of Indobufen.Investigational
IndomethacinThe metabolism of Indomethacin can be decreased when combined with Ticlopidine.Approved, Investigational
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Ticlopidine.Approved
IrbesartanThe metabolism of Irbesartan can be decreased when combined with Ticlopidine.Approved, Investigational
IrinotecanThe metabolism of Irinotecan can be decreased when combined with Ticlopidine.Approved, Investigational
IsavuconazoniumThe metabolism of Isavuconazonium can be decreased when combined with Ticlopidine.Approved, Investigational
IsofluraneThe metabolism of Isoflurane can be decreased when combined with Ticlopidine.Approved, Vet Approved
IsoniazidThe metabolism of Ticlopidine can be decreased when combined with Isoniazid.Approved
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Ticlopidine.Approved
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Ticlopidine.Approved
IsradipineThe metabolism of Isradipine can be decreased when combined with Ticlopidine.Approved
ItraconazoleThe metabolism of Ticlopidine can be decreased when combined with Itraconazole.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Ticlopidine.Approved
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Ticlopidine.Approved
IvermectinThe metabolism of Ivermectin can be decreased when combined with Ticlopidine.Approved, Vet Approved
IxabepiloneThe metabolism of Ixabepilone can be decreased when combined with Ticlopidine.Approved, Investigational
IxazomibThe metabolism of Ixazomib can be decreased when combined with Ticlopidine.Approved
Kct 0809Ticlopidine may increase the anticoagulant activities of Kct 0809.Investigational
KetamineThe metabolism of Ketamine can be decreased when combined with Ticlopidine.Approved, Vet Approved
KetanserinKetanserin may increase the anticoagulant activities of Ticlopidine.Investigational
KetazolamThe metabolism of Ketazolam can be decreased when combined with Ticlopidine.Approved
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Ticlopidine.Approved
KetoconazoleThe metabolism of Ticlopidine can be decreased when combined with Ketoconazole.Approved, Investigational
KetoprofenThe metabolism of Ketoprofen can be decreased when combined with Ticlopidine.Approved, Vet Approved
LabetalolThe metabolism of Labetalol can be decreased when combined with Ticlopidine.Approved
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Ticlopidine.Approved, Investigational
LapatinibThe metabolism of Lapatinib can be decreased when combined with Ticlopidine.Approved, Investigational
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Ticlopidine.Investigational
LeflunomideThe metabolism of Leflunomide can be decreased when combined with Ticlopidine.Approved, Investigational
LenvatinibThe metabolism of Lenvatinib can be decreased when combined with Ticlopidine.Approved
LepirudinTiclopidine may increase the anticoagulant activities of Lepirudin.Approved
LercanidipineThe metabolism of Lercanidipine can be decreased when combined with Ticlopidine.Approved, Investigational
LesinuradThe metabolism of Lesinurad can be decreased when combined with Ticlopidine.Approved
LetrozoleThe metabolism of Letrozole can be decreased when combined with Ticlopidine.Approved, Investigational
LevobupivacaineThe metabolism of Levobupivacaine can be decreased when combined with Ticlopidine.Approved
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Ticlopidine.Approved
LevodopaThe metabolism of Levodopa can be decreased when combined with Ticlopidine.Approved
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Ticlopidine.Approved
LevomilnacipranThe metabolism of Levomilnacipran can be decreased when combined with Ticlopidine.Approved
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Ticlopidine.Approved, Investigational
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Ticlopidine.Approved
LicofeloneThe metabolism of Licofelone can be decreased when combined with Ticlopidine.Investigational
LidocaineThe metabolism of Lidocaine can be decreased when combined with Ticlopidine.Approved, Vet Approved
LimaprostThe risk or severity of adverse effects can be increased when Limaprost is combined with Ticlopidine.Approved
LisurideThe metabolism of Lisuride can be decreased when combined with Ticlopidine.Approved
LomefloxacinThe metabolism of Lomefloxacin can be decreased when combined with Ticlopidine.Approved
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Ticlopidine.Approved
LomustineThe metabolism of Lomustine can be decreased when combined with Ticlopidine.Approved
LoperamideThe metabolism of Loperamide can be decreased when combined with Ticlopidine.Approved
LopinavirThe metabolism of Ticlopidine can be decreased when combined with Lopinavir.Approved
LoratadineThe metabolism of Loratadine can be decreased when combined with Ticlopidine.Approved
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Ticlopidine.Approved
LornoxicamThe metabolism of Lornoxicam can be decreased when combined with Ticlopidine.Approved
LosartanThe metabolism of Losartan can be decreased when combined with Ticlopidine.Approved
LovastatinThe metabolism of Lovastatin can be decreased when combined with Ticlopidine.Approved, Investigational
LuliconazoleThe serum concentration of Ticlopidine can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Ticlopidine can be decreased when it is combined with Lumacaftor.Approved
LumefantrineThe metabolism of Lumefantrine can be decreased when combined with Ticlopidine.Approved
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Ticlopidine.Approved, Investigational
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Ticlopidine.Approved
MacitentanThe metabolism of Macitentan can be decreased when combined with Ticlopidine.Approved
MalathionThe metabolism of Malathion can be decreased when combined with Ticlopidine.Approved, Investigational
MaprotilineThe metabolism of Maprotiline can be decreased when combined with Ticlopidine.Approved
MaravirocThe metabolism of Maraviroc can be decreased when combined with Ticlopidine.Approved, Investigational
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Ticlopidine.Approved, Vet Approved
Medroxyprogesterone acetateThe metabolism of Medroxyprogesterone acetate can be decreased when combined with Ticlopidine.Approved, Investigational
Mefenamic acidThe metabolism of Mefenamic acid can be decreased when combined with Ticlopidine.Approved
MefloquineThe metabolism of Mefloquine can be decreased when combined with Ticlopidine.Approved
MelatoninThe metabolism of Melatonin can be decreased when combined with Ticlopidine.Approved, Nutraceutical, Vet Approved
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Ticlopidine.Approved, Vet Approved
MenadioneThe metabolism of Menadione can be decreased when combined with Ticlopidine.Approved, Nutraceutical
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Ticlopidine.Investigational, Withdrawn
MeprobamateThe metabolism of Meprobamate can be decreased when combined with Ticlopidine.Approved, Illicit
MequitazineThe metabolism of Mequitazine can be decreased when combined with Ticlopidine.Approved
MesalazineThe risk or severity of adverse effects can be increased when Ticlopidine is combined with Mesalazine.Approved
MesoridazineThe metabolism of Mesoridazine can be decreased when combined with Ticlopidine.Approved
MestranolThe metabolism of Mestranol can be decreased when combined with Ticlopidine.Approved
MethadoneThe metabolism of Methadone can be decreased when combined with Ticlopidine.Approved
MethamphetamineThe metabolism of Methamphetamine can be decreased when combined with Ticlopidine.Approved, Illicit
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Ticlopidine.Illicit, Withdrawn
MethotrimeprazineThe metabolism of Ticlopidine can be decreased when combined with Methotrimeprazine.Approved
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Ticlopidine.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Ticlopidine.Approved, Vet Approved
MethsuximideThe metabolism of Methsuximide can be decreased when combined with Ticlopidine.Approved
MethylphenidateThe metabolism of Methylphenidate can be decreased when combined with Ticlopidine.Approved, Investigational
MethylphenobarbitalThe metabolism of Methylphenobarbital can be decreased when combined with Ticlopidine.Approved
MethylprednisoloneThe metabolism of Methylprednisolone can be decreased when combined with Ticlopidine.Approved, Vet Approved
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Ticlopidine.Approved
MethyprylonThe metabolism of Methyprylon can be decreased when combined with Ticlopidine.Approved, Illicit, Withdrawn
MetoclopramideThe metabolism of Metoclopramide can be decreased when combined with Ticlopidine.Approved, Investigational
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Ticlopidine.Approved, Investigational
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Ticlopidine.Approved
MexiletineThe metabolism of Mexiletine can be decreased when combined with Ticlopidine.Approved
MianserinThe metabolism of Mianserin can be decreased when combined with Ticlopidine.Approved
MibefradilThe metabolism of Mibefradil can be decreased when combined with Ticlopidine.Withdrawn
MiconazoleThe metabolism of Miconazole can be decreased when combined with Ticlopidine.Approved, Investigational, Vet Approved
MidazolamThe metabolism of Midazolam can be decreased when combined with Ticlopidine.Approved, Illicit
MifepristoneThe serum concentration of Ticlopidine can be increased when it is combined with Mifepristone.Approved, Investigational
MilrinoneMilrinone may increase the anticoagulant activities of Ticlopidine.Approved
MinaprineThe metabolism of Minaprine can be decreased when combined with Ticlopidine.Approved
MirabegronThe metabolism of Mirabegron can be decreased when combined with Ticlopidine.Approved
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Ticlopidine.Approved
MitotaneThe serum concentration of Ticlopidine can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe metabolism of Mitoxantrone can be decreased when combined with Ticlopidine.Approved, Investigational
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Ticlopidine.Approved
ModafinilThe serum concentration of Ticlopidine can be decreased when it is combined with Modafinil.Approved, Investigational
MontelukastThe metabolism of Montelukast can be decreased when combined with Ticlopidine.Approved
MorphineThe metabolism of Morphine can be decreased when combined with Ticlopidine.Approved, Investigational
muraglitazarThe metabolism of muraglitazar can be decreased when combined with Ticlopidine.Investigational
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Ticlopidine.Approved, Investigational
NabumetoneThe metabolism of Nabumetone can be decreased when combined with Ticlopidine.Approved
NadroparinTiclopidine may increase the anticoagulant activities of Nadroparin.Approved
NafamostatTiclopidine may increase the anticoagulant activities of Nafamostat.Investigational
NafcillinThe serum concentration of Ticlopidine can be decreased when it is combined with Nafcillin.Approved
NaftopidilNaftopidil may increase the anticoagulant activities of Ticlopidine.Investigational
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Ticlopidine.Approved
NaloxoneThe metabolism of Naloxone can be decreased when combined with Ticlopidine.Approved, Vet Approved
NaproxenThe metabolism of Naproxen can be decreased when combined with Ticlopidine.Approved, Vet Approved
NateglinideThe metabolism of Nateglinide can be decreased when combined with Ticlopidine.Approved, Investigational
NCX 4016The risk or severity of adverse effects can be increased when Ticlopidine is combined with NCX 4016.Investigational
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Ticlopidine.Approved, Investigational
NefazodoneThe metabolism of Ticlopidine can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe metabolism of Ticlopidine can be decreased when combined with Nelfinavir.Approved
NetupitantThe serum concentration of Ticlopidine can be increased when it is combined with Netupitant.Approved
NevirapineThe metabolism of Ticlopidine can be increased when combined with Nevirapine.Approved
NicardipineThe metabolism of Nicardipine can be decreased when combined with Ticlopidine.Approved
NicergolineThe metabolism of Nicergoline can be decreased when combined with Ticlopidine.Approved
NiclosamideThe metabolism of Niclosamide can be decreased when combined with Ticlopidine.Approved, Vet Approved
NicotineThe metabolism of Nicotine can be decreased when combined with Ticlopidine.Approved
NifedipineThe metabolism of Nifedipine can be decreased when combined with Ticlopidine.Approved
NilotinibThe metabolism of Nilotinib can be decreased when combined with Ticlopidine.Approved, Investigational
NilutamideThe metabolism of Nilutamide can be decreased when combined with Ticlopidine.Approved
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Ticlopidine.Approved
NimesulideNimesulide may increase the anticoagulant activities of Ticlopidine.Approved, Withdrawn
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Ticlopidine.Approved
NisoldipineThe metabolism of Nisoldipine can be decreased when combined with Ticlopidine.Approved
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Ticlopidine.Approved
NitrendipineThe metabolism of Nitrendipine can be decreased when combined with Ticlopidine.Approved
Nitric OxideThe metabolism of Nitric Oxide can be decreased when combined with Ticlopidine.Approved
NitroaspirinThe risk or severity of adverse effects can be increased when Ticlopidine is combined with Nitroaspirin.Investigational
NitrofuralThe metabolism of Nitrofural can be decreased when combined with Ticlopidine.Approved, Vet Approved
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Ticlopidine.Approved
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Ticlopidine.Approved
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Ticlopidine.Approved
ObinutuzumabThe risk or severity of adverse effects can be increased when Ticlopidine is combined with Obinutuzumab.Approved
OlanzapineThe metabolism of Olanzapine can be decreased when combined with Ticlopidine.Approved, Investigational
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Ticlopidine.Approved
OlodaterolThe metabolism of Olodaterol can be decreased when combined with Ticlopidine.Approved
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Ticlopidine.Approved
OlsalazineThe risk or severity of adverse effects can be increased when Ticlopidine is combined with Olsalazine.Approved
Omega-3 fatty acidsOmega-3 fatty acids may increase the antiplatelet activities of Ticlopidine.Approved
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Ticlopidine.Approved, Investigational, Vet Approved
OndansetronThe metabolism of Ondansetron can be decreased when combined with Ticlopidine.Approved
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Ticlopidine.Approved
OsimertinibThe serum concentration of Ticlopidine can be increased when it is combined with Osimertinib.Approved
OspemifeneThe metabolism of Ospemifene can be decreased when combined with Ticlopidine.Approved
OtamixabanTiclopidine may increase the anticoagulant activities of Otamixaban.Investigational
OxaliplatinThe metabolism of Oxaliplatin can be decreased when combined with Ticlopidine.Approved, Investigational
OxaprozinThe metabolism of Oxaprozin can be decreased when combined with Ticlopidine.Approved
OxazepamThe metabolism of Oxazepam can be decreased when combined with Ticlopidine.Approved
OxiconazoleThe metabolism of Oxiconazole can be decreased when combined with Ticlopidine.Approved
OxtriphyllineThe metabolism of Oxtriphylline can be decreased when combined with Ticlopidine.Approved
OxybutyninThe metabolism of Oxybutynin can be decreased when combined with Ticlopidine.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Ticlopidine is combined with Oxycodone.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Ticlopidine.Approved, Investigational, Vet Approved
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Ticlopidine.Approved, Vet Approved
PalbociclibThe serum concentration of Ticlopidine can be increased when it is combined with Palbociclib.Approved
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Ticlopidine.Approved, Investigational
PanobinostatThe serum concentration of Ticlopidine can be increased when it is combined with Panobinostat.Approved, Investigational
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Ticlopidine.Approved
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Ticlopidine.Approved
ParamethasoneThe metabolism of Paramethasone can be decreased when combined with Ticlopidine.Approved
ParecoxibThe metabolism of Parecoxib can be decreased when combined with Ticlopidine.Approved
ParicalcitolThe metabolism of Paricalcitol can be decreased when combined with Ticlopidine.Approved, Investigational
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Ticlopidine.Approved
ParnaparinTiclopidine may increase the anticoagulant activities of Parnaparin.Approved
ParoxetineThe metabolism of Ticlopidine can be decreased when combined with Paroxetine.Approved, Investigational
PazopanibThe metabolism of Pazopanib can be decreased when combined with Ticlopidine.Approved
Peginterferon alfa-2bThe serum concentration of Ticlopidine can be decreased when it is combined with Peginterferon alfa-2b.Approved
PentamidineThe metabolism of Pentamidine can be decreased when combined with Ticlopidine.Approved
PentobarbitalThe metabolism of Ticlopidine can be increased when combined with Pentobarbital.Approved, Vet Approved
Pentosan PolysulfateThe risk or severity of adverse effects can be increased when Pentosan Polysulfate is combined with Ticlopidine.Approved
PentoxifyllinePentoxifylline may increase the antiplatelet activities of Ticlopidine.Approved, Investigational
PerampanelThe metabolism of Perampanel can be decreased when combined with Ticlopidine.Approved
PergolideThe metabolism of Pergolide can be decreased when combined with Ticlopidine.Approved, Vet Approved, Withdrawn
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Ticlopidine.Approved
PermethrinThe metabolism of Permethrin can be decreased when combined with Ticlopidine.Approved, Investigational
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Ticlopidine.Approved
PethidineThe metabolism of Pethidine can be decreased when combined with Ticlopidine.Approved
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Ticlopidine.Withdrawn
PhenforminThe metabolism of Phenformin can be decreased when combined with Ticlopidine.Approved, Withdrawn
PhenindioneTiclopidine may increase the anticoagulant activities of Phenindione.Approved
PhenobarbitalThe metabolism of Ticlopidine can be increased when combined with Phenobarbital.Approved
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Ticlopidine.Approved
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Ticlopidine.Approved
PhenylbutazoneThe metabolism of Phenylbutazone can be decreased when combined with Ticlopidine.Approved, Vet Approved
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Ticlopidine.Approved, Vet Approved
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Ticlopidine.Approved
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Ticlopidine.Approved, Investigational
PimozideThe serum concentration of Pimozide can be increased when it is combined with Ticlopidine.Approved
PinacidilThe metabolism of Pinacidil can be decreased when combined with Ticlopidine.Withdrawn
PindololThe metabolism of Pindolol can be decreased when combined with Ticlopidine.Approved
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Ticlopidine.Approved, Investigational
PiperazineThe metabolism of Piperazine can be decreased when combined with Ticlopidine.Approved, Vet Approved
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Ticlopidine.Approved
PirfenidoneThe serum concentration of Pirfenidone can be increased when it is combined with Ticlopidine.Investigational
PiroxicamThe metabolism of Piroxicam can be decreased when combined with Ticlopidine.Approved, Investigational
PitavastatinThe metabolism of Pitavastatin can be decreased when combined with Ticlopidine.Approved
PlasminTiclopidine may increase the anticoagulant activities of Plasmin.Investigational
PodofiloxThe metabolism of Podofilox can be decreased when combined with Ticlopidine.Approved
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Ticlopidine.Approved
PonatinibThe metabolism of Ponatinib can be decreased when combined with Ticlopidine.Approved
PosaconazoleThe metabolism of Ticlopidine can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PrasteroneThe metabolism of Prasterone can be decreased when combined with Ticlopidine.Approved, Nutraceutical
PrasugrelThe metabolism of Prasugrel can be decreased when combined with Ticlopidine.Approved
PravastatinThe metabolism of Pravastatin can be decreased when combined with Ticlopidine.Approved
PrazepamThe metabolism of Prazepam can be decreased when combined with Ticlopidine.Approved, Illicit
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Ticlopidine.Approved, Vet Approved
PrednisoloneThe metabolism of Prednisolone can be decreased when combined with Ticlopidine.Approved, Vet Approved
PrednisoneThe metabolism of Prednisone can be decreased when combined with Ticlopidine.Approved, Vet Approved
PrimaquineThe metabolism of Primaquine can be decreased when combined with Ticlopidine.Approved
PrimidoneThe metabolism of Ticlopidine can be increased when combined with Primidone.Approved, Vet Approved
ProcainamideThe metabolism of Procainamide can be decreased when combined with Ticlopidine.Approved
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Ticlopidine.Approved, Vet Approved
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Ticlopidine.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be decreased when combined with Ticlopidine.Approved
PromazineThe metabolism of Promazine can be decreased when combined with Ticlopidine.Approved, Vet Approved
PromethazineThe metabolism of Promethazine can be decreased when combined with Ticlopidine.Approved
PropafenoneThe serum concentration of Ticlopidine can be increased when it is combined with Propafenone.Approved
PropofolThe metabolism of Propofol can be decreased when combined with Ticlopidine.Approved, Investigational, Vet Approved
PropranololThe metabolism of Propranolol can be decreased when combined with Ticlopidine.Approved, Investigational
Protein CTiclopidine may increase the anticoagulant activities of Protein C.Approved
Protein S humanTiclopidine may increase the anticoagulant activities of Protein S human.Approved
ProtocatechualdehydeTiclopidine may increase the anticoagulant activities of Protocatechualdehyde.Approved
ProtriptylineThe metabolism of Protriptyline can be decreased when combined with Ticlopidine.Approved
PseudoephedrineThe metabolism of Pseudoephedrine can be decreased when combined with Ticlopidine.Approved
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Ticlopidine.Approved
QuazepamThe metabolism of Quazepam can be decreased when combined with Ticlopidine.Approved, Illicit
QuetiapineThe metabolism of Quetiapine can be decreased when combined with Ticlopidine.Approved
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Ticlopidine.Approved
QuinidineThe metabolism of Ticlopidine can be decreased when combined with Quinidine.Approved
QuinineThe metabolism of Quinine can be decreased when combined with Ticlopidine.Approved
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Ticlopidine.Approved, Investigational
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Ticlopidine.Approved, Investigational
RamatrobanRamatroban may increase the anticoagulant activities of Ticlopidine.Investigational
RamelteonThe metabolism of Ramelteon can be decreased when combined with Ticlopidine.Approved, Investigational
RanitidineThe metabolism of Ranitidine can be decreased when combined with Ticlopidine.Approved
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Ticlopidine.Approved, Investigational
RasagilineThe metabolism of Rasagiline can be decreased when combined with Ticlopidine.Approved
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Ticlopidine.Approved, Investigational
RegorafenibThe metabolism of Regorafenib can be decreased when combined with Ticlopidine.Approved
RemoxiprideThe metabolism of Remoxipride can be decreased when combined with Ticlopidine.Approved, Withdrawn
RepaglinideThe metabolism of Repaglinide can be decreased when combined with Ticlopidine.Approved, Investigational
repinotanThe metabolism of repinotan can be decreased when combined with Ticlopidine.Investigational
ResveratrolThe metabolism of Resveratrol can be decreased when combined with Ticlopidine.Experimental, Investigational
RetapamulinThe metabolism of Retapamulin can be decreased when combined with Ticlopidine.Approved
ReteplaseTiclopidine may increase the anticoagulant activities of Reteplase.Approved
ReviparinTiclopidine may increase the anticoagulant activities of Reviparin.Approved
RidogrelRidogrel may increase the anticoagulant activities of Ticlopidine.Approved
RifabutinThe metabolism of Ticlopidine can be increased when combined with Rifabutin.Approved
RifampicinThe metabolism of Ticlopidine can be increased when combined with Rifampicin.Approved
RifapentineThe metabolism of Ticlopidine can be increased when combined with Rifapentine.Approved
RilpivirineThe metabolism of Rilpivirine can be decreased when combined with Ticlopidine.Approved
RiluzoleThe metabolism of Riluzole can be decreased when combined with Ticlopidine.Approved, Investigational
RimonabantThe metabolism of Rimonabant can be decreased when combined with Ticlopidine.Approved, Investigational
RiociguatThe metabolism of Riociguat can be decreased when combined with Ticlopidine.Approved
RisperidoneThe metabolism of Risperidone can be decreased when combined with Ticlopidine.Approved, Investigational
RitonavirThe metabolism of Ticlopidine can be decreased when combined with Ritonavir.Approved, Investigational
RivaroxabanTiclopidine may increase the anticoagulant activities of Rivaroxaban.Approved
RizatriptanThe metabolism of Rizatriptan can be decreased when combined with Ticlopidine.Approved
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Ticlopidine.Investigational, Withdrawn
RolapitantThe metabolism of Rolapitant can be decreased when combined with Ticlopidine.Approved
RomidepsinThe metabolism of Romidepsin can be decreased when combined with Ticlopidine.Approved, Investigational
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Ticlopidine.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Ticlopidine.Approved
RosiglitazoneThe metabolism of Rosiglitazone can be decreased when combined with Ticlopidine.Approved, Investigational
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Ticlopidine.Approved
RotigotineThe metabolism of Rotigotine can be decreased when combined with Ticlopidine.Approved
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Ticlopidine.Approved, Withdrawn
RuxolitinibThe metabolism of Ruxolitinib can be decreased when combined with Ticlopidine.Approved
Salicylic acidThe risk or severity of adverse effects can be increased when Ticlopidine is combined with Salicylic acid.Approved, Vet Approved
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Ticlopidine.Approved
SaquinavirThe metabolism of Ticlopidine can be decreased when combined with Saquinavir.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Ticlopidine.Approved
SCH-530348SCH-530348 may increase the anticoagulant activities of Ticlopidine.Investigational
SelegilineThe metabolism of Selegiline can be decreased when combined with Ticlopidine.Approved, Investigational, Vet Approved
SelexipagThe metabolism of Selexipag can be decreased when combined with Ticlopidine.Approved
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Ticlopidine.Approved, Investigational
SertindoleThe metabolism of Sertindole can be decreased when combined with Ticlopidine.Approved, Withdrawn
SertralineThe metabolism of Sertraline can be decreased when combined with Ticlopidine.Approved
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Ticlopidine.Approved, Vet Approved
SibutramineThe metabolism of Sibutramine can be decreased when combined with Ticlopidine.Approved, Illicit, Investigational, Withdrawn
SildenafilThe metabolism of Sildenafil can be decreased when combined with Ticlopidine.Approved, Investigational
SilodosinThe metabolism of Silodosin can be decreased when combined with Ticlopidine.Approved
SiltuximabThe serum concentration of Ticlopidine can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Ticlopidine.Approved
SimvastatinThe metabolism of Simvastatin can be decreased when combined with Ticlopidine.Approved
SirolimusThe metabolism of Sirolimus can be decreased when combined with Ticlopidine.Approved, Investigational
SitagliptinThe metabolism of Sitagliptin can be decreased when combined with Ticlopidine.Approved, Investigational
SitaxentanThe metabolism of Sitaxentan can be decreased when combined with Ticlopidine.Approved, Investigational, Withdrawn
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Ticlopidine.Approved
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Ticlopidine.Approved, Investigational
SorafenibThe metabolism of Sorafenib can be decreased when combined with Ticlopidine.Approved, Investigational
SparteineThe metabolism of Sparteine can be decreased when combined with Ticlopidine.Experimental
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Ticlopidine.Approved
SRT501SRT501 may increase the anticoagulant activities of Ticlopidine.Investigational
St. John's WortThe serum concentration of Ticlopidine can be decreased when it is combined with St. John's Wort.Nutraceutical
StiripentolThe serum concentration of Ticlopidine can be increased when it is combined with Stiripentol.Approved
StreptokinaseTiclopidine may increase the anticoagulant activities of Streptokinase.Approved
SufentanilThe metabolism of Sufentanil can be decreased when combined with Ticlopidine.Approved, Investigational
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Ticlopidine.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Ticlopidine.Approved
SulfamoxoleThe metabolism of Sulfamoxole can be decreased when combined with Ticlopidine.Approved
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Ticlopidine.Approved
SulfisoxazoleThe metabolism of Ticlopidine can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SulodexideTiclopidine may increase the anticoagulant activities of Sulodexide.Approved, Investigational
SunitinibThe metabolism of Sunitinib can be decreased when combined with Ticlopidine.Approved, Investigational
SuprofenThe metabolism of Suprofen can be decreased when combined with Ticlopidine.Approved, Withdrawn
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Ticlopidine.Approved
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Ticlopidine.Approved
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Ticlopidine.Approved
TacrineThe metabolism of Tacrine can be decreased when combined with Ticlopidine.Withdrawn
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Ticlopidine.Approved, Investigational
TadalafilThe metabolism of Tadalafil can be decreased when combined with Ticlopidine.Approved, Investigational
TamoxifenThe serum concentration of the active metabolites of Tamoxifen can be reduced when Tamoxifen is used in combination with Ticlopidine resulting in a loss in efficacy.Approved
TamsulosinThe metabolism of Tamsulosin can be decreased when combined with Ticlopidine.Approved, Investigational
TapentadolThe metabolism of Tapentadol can be decreased when combined with Ticlopidine.Approved
TasosartanThe metabolism of Tasosartan can be decreased when combined with Ticlopidine.Approved
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Ticlopidine.Experimental
TegaserodThe metabolism of Tegaserod can be decreased when combined with Ticlopidine.Investigational, Withdrawn
TelaprevirThe metabolism of Ticlopidine can be decreased when combined with Telaprevir.Approved
TelithromycinThe metabolism of Ticlopidine can be decreased when combined with Telithromycin.Approved
TemafloxacinThe metabolism of Temafloxacin can be decreased when combined with Ticlopidine.Withdrawn
TemazepamThe metabolism of Temazepam can be decreased when combined with Ticlopidine.Approved
TemsirolimusThe metabolism of Temsirolimus can be decreased when combined with Ticlopidine.Approved
TenecteplaseTiclopidine may increase the anticoagulant activities of Tenecteplase.Approved
TeniposideThe metabolism of Teniposide can be decreased when combined with Ticlopidine.Approved
TenoxicamThe metabolism of Tenoxicam can be decreased when combined with Ticlopidine.Approved
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Ticlopidine.Approved, Investigational, Vet Approved
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Ticlopidine.Withdrawn
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Ticlopidine.Investigational
TestosteroneThe metabolism of Testosterone can be decreased when combined with Ticlopidine.Approved, Investigational
TetrabenazineThe metabolism of Tetrabenazine can be decreased when combined with Ticlopidine.Approved
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Ticlopidine.Approved, Vet Approved
ThalidomideThe metabolism of Thalidomide can be decreased when combined with Ticlopidine.Approved, Investigational, Withdrawn
TheobromineThe metabolism of Theobromine can be decreased when combined with Ticlopidine.Approved
TheophyllineThe metabolism of Theophylline can be decreased when combined with Ticlopidine.Approved
ThiabendazoleThe metabolism of Thiabendazole can be decreased when combined with Ticlopidine.Approved, Vet Approved
ThiamylalThe metabolism of Thiamylal can be decreased when combined with Ticlopidine.Approved, Vet Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Ticlopidine.Approved
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Ticlopidine.Approved
ThiothixeneThe metabolism of Thiothixene can be decreased when combined with Ticlopidine.Approved
TiagabineThe metabolism of Tiagabine can be decreased when combined with Ticlopidine.Approved
TicagrelorThe metabolism of Ticagrelor can be decreased when combined with Ticlopidine.Approved
TimololThe metabolism of Timolol can be decreased when combined with Ticlopidine.Approved
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Ticlopidine.Approved, Investigational
TinzaparinTiclopidine may increase the anticoagulant activities of Tinzaparin.Approved
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Ticlopidine.Approved
TipranavirTipranavir may increase the antiplatelet activities of Ticlopidine.Approved, Investigational
TirapazamineThe metabolism of Tirapazamine can be decreased when combined with Ticlopidine.Investigational
TirofibanTiclopidine may increase the anticoagulant activities of Tirofiban.Approved
TizanidineThe serum concentration of Tizanidine can be increased when it is combined with Ticlopidine.Approved
TocilizumabThe serum concentration of Ticlopidine can be decreased when it is combined with Tocilizumab.Approved
TofacitinibThe metabolism of Tofacitinib can be decreased when combined with Ticlopidine.Approved, Investigational
TolbutamideThe metabolism of Tolbutamide can be decreased when combined with Ticlopidine.Approved
TolterodineThe metabolism of Tolterodine can be decreased when combined with Ticlopidine.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Ticlopidine.Approved
TopiramateThe metabolism of Ticlopidine can be decreased when combined with Topiramate.Approved
TorasemideThe metabolism of Torasemide can be decreased when combined with Ticlopidine.Approved
ToremifeneThe metabolism of Toremifene can be decreased when combined with Ticlopidine.Approved, Investigational
TositumomabThe risk or severity of adverse effects can be increased when Ticlopidine is combined with Tositumomab.Approved
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Ticlopidine.Approved, Investigational
TramadolThe therapeutic efficacy of Tramadol can be decreased when used in combination with Ticlopidine.Approved, Investigational
TranilastTranilast may increase the anticoagulant activities of Ticlopidine.Approved, Investigational
TranylcypromineThe metabolism of Ticlopidine can be decreased when combined with Tranylcypromine.Approved
TrapidilTrapidil may increase the anticoagulant activities of Ticlopidine.Approved
Trastuzumab emtansineThe metabolism of Trastuzumab emtansine can be decreased when combined with Ticlopidine.Approved
TrazodoneThe metabolism of Trazodone can be decreased when combined with Ticlopidine.Approved, Investigational
TreprostinilTreprostinil may increase the antiplatelet activities of Ticlopidine.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be decreased when combined with Ticlopidine.Approved, Investigational, Nutraceutical
TriamcinoloneThe metabolism of Triamcinolone can be decreased when combined with Ticlopidine.Approved, Vet Approved
TriamtereneThe metabolism of Triamterene can be decreased when combined with Ticlopidine.Approved
TriazolamThe metabolism of Triazolam can be decreased when combined with Ticlopidine.Approved
TrifluoperazineThe metabolism of Trifluoperazine can be decreased when combined with Ticlopidine.Approved
TriflusalTiclopidine may increase the anticoagulant activities of Triflusal.Approved
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Ticlopidine.Approved
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Ticlopidine.Approved, Vet Approved
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Ticlopidine.Approved
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Ticlopidine.Withdrawn
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Ticlopidine.Approved
UdenafilThe metabolism of Udenafil can be decreased when combined with Ticlopidine.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Ticlopidine.Approved
UmeclidiniumThe metabolism of Umeclidinium can be decreased when combined with Ticlopidine.Approved
UrokinaseTiclopidine may increase the anticoagulant activities of Urokinase.Approved, Investigational, Withdrawn
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Ticlopidine.Investigational, Withdrawn
Valproic AcidThe metabolism of Valproic Acid can be decreased when combined with Ticlopidine.Approved, Investigational
ValsartanThe metabolism of Valsartan can be decreased when combined with Ticlopidine.Approved, Investigational
VandetanibThe metabolism of Vandetanib can be decreased when combined with Ticlopidine.Approved
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Ticlopidine.Investigational
VardenafilThe metabolism of Vardenafil can be decreased when combined with Ticlopidine.Approved
VemurafenibThe metabolism of Vemurafenib can be decreased when combined with Ticlopidine.Approved
VenetoclaxThe metabolism of Venetoclax can be decreased when combined with Ticlopidine.Approved
VenlafaxineThe metabolism of Venlafaxine can be decreased when combined with Ticlopidine.Approved
VerapamilThe metabolism of Verapamil can be decreased when combined with Ticlopidine.Approved
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Ticlopidine.Investigational
VilanterolThe metabolism of Vilanterol can be decreased when combined with Ticlopidine.Approved
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Ticlopidine.Approved
VinblastineThe metabolism of Vinblastine can be decreased when combined with Ticlopidine.Approved
VincristineThe metabolism of Vincristine can be decreased when combined with Ticlopidine.Approved, Investigational
VindesineThe serum concentration of Vindesine can be increased when it is combined with Ticlopidine.Approved
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Ticlopidine.Approved, Investigational
VismodegibThe metabolism of Vismodegib can be decreased when combined with Ticlopidine.Approved
Vitamin EVitamin E may increase the antiplatelet activities of Ticlopidine.Approved, Nutraceutical, Vet Approved
VorapaxarTiclopidine may increase the anticoagulant activities of Vorapaxar.Approved
VoriconazoleThe metabolism of Ticlopidine can be decreased when combined with Voriconazole.Approved, Investigational
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Ticlopidine.Approved
WarfarinThe metabolism of Warfarin can be decreased when combined with Ticlopidine.Approved
XimelagatranThe metabolism of Ximelagatran can be decreased when combined with Ticlopidine.Approved, Investigational, Withdrawn
Ym150Ticlopidine may increase the anticoagulant activities of Ym150.Investigational
YohimbineThe metabolism of Yohimbine can be decreased when combined with Ticlopidine.Approved, Vet Approved
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Ticlopidine.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Ticlopidine.Approved
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Ticlopidine.Approved, Illicit, Investigational
ZaltoprofenThe metabolism of Zaltoprofen can be decreased when combined with Ticlopidine.Approved
ZidovudineThe metabolism of Zidovudine can be decreased when combined with Ticlopidine.Approved
ZileutonThe metabolism of Zileuton can be decreased when combined with Ticlopidine.Approved, Investigational, Withdrawn
ZiprasidoneThe metabolism of Ziprasidone can be decreased when combined with Ticlopidine.Approved
ZolmitriptanThe metabolism of Zolmitriptan can be decreased when combined with Ticlopidine.Approved, Investigational
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Ticlopidine.Approved
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Ticlopidine.Withdrawn
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Ticlopidine.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Ticlopidine.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Ticlopidine.Approved, Investigational
Food Interactions
  • High fat meals will increase ticlopidine absorption. As well, food can help ticlopidine-induced stomach upset.
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External Links
ATC CodesB01AC05
AHFS Codes
  • 20:12.18
PDB EntriesNot Available
FDA labelDownload (916 KB)
MSDSDownload (106 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9902
Blood Brain Barrier+0.9906
Caco-2 permeable+0.6062
P-glycoprotein substrateSubstrate0.6111
P-glycoprotein inhibitor IInhibitor0.8
P-glycoprotein inhibitor IIInhibitor0.8513
Renal organic cation transporterInhibitor0.8152
CYP450 2C9 substrateNon-substrate0.8234
CYP450 2D6 substrateNon-substrate0.9115
CYP450 3A4 substrateNon-substrate0.5155
CYP450 1A2 substrateInhibitor0.9107
CYP450 2C9 inhibitorNon-inhibitor0.907
CYP450 2D6 inhibitorInhibitor0.9209
CYP450 2C19 inhibitorInhibitor0.8994
CYP450 3A4 inhibitorNon-inhibitor0.8808
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.9666
Ames testNon AMES toxic0.6773
CarcinogenicityNon-carcinogens0.9414
BiodegradationNot ready biodegradable0.9959
Rat acute toxicity2.2022 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Strong inhibitor0.6392
hERG inhibition (predictor II)Inhibitor0.6333
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Roche palo alto llc
  • Actavis elizabeth llc
  • Apotex inc
  • Caraco pharmaceutical laboratories ltd
  • Genpharm inc
  • Mylan pharmaceuticals inc
  • Sandoz inc
  • Teva pharmaceuticals usa inc
  • Watson laboratories inc
Packagers
Dosage forms
FormRouteStrength
TabletOral250 mg
Tablet, film coatedOral250 mg/1
Prices
Unit descriptionCostUnit
Ticlid 30 250 mg tablet Bottle87.36USD bottle
Ticlid 250 mg tablet2.61USD tablet
Ticlopidine HCl 250 mg tablet2.1USD tablet
Ticlopidine 250 mg tablet1.86USD tablet
Apo-Ticlopidine 250 mg Tablet0.72USD tablet
Mylan-Ticlopidine 250 mg Tablet0.72USD tablet
Novo-Ticlopidine 250 mg Tablet0.72USD tablet
Nu-Ticlopidine 250 mg Tablet0.72USD tablet
Sandoz Ticlopidine 250 mg Tablet0.72USD tablet
Ticlopidine 250 mg Tablet0.72USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting pointapprox. 1 189°CFrom Remington: The Science and Practice of Pharmacy
water solubilityFreely solubleFrom Remington: The Science and Practice of Pharmacy
logP2.9Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0219 mg/mLALOGPS
logP4.25ALOGPS
logP4.2ChemAxon
logS-4.1ALOGPS
pKa (Strongest Basic)7.31ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area3.24 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity74.33 m3·mol-1ChemAxon
Polarizability27.99 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as thienopyridines. These are heterocyclic compounds containing a thiophene ring fused to a pyridine ring. Thiophene is 5-membered ring consisting of four carbon atoms and one sulfur atom. Pyridine is a 6-membered ring consisting of five carbon atoms and one nitrogen center.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassThienopyridines
Sub ClassNot Available
Direct ParentThienopyridines
Alternative Parents
Substituents
  • Thienopyridine
  • Phenylmethylamine
  • Benzylamine
  • Aralkylamine
  • Halobenzene
  • Chlorobenzene
  • Benzenoid
  • Pyridine
  • Monocyclic benzene moiety
  • Aryl halide
  • Aryl chloride
  • Heteroaromatic compound
  • Thiophene
  • Tertiary aliphatic amine
  • Tertiary amine
  • Azacycle
  • Hydrocarbon derivative
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Guanyl-nucleotide exchange factor activity
Specific Function:
Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation.
Gene Name:
P2RY12
Uniprot ID:
Q9H244
Molecular Weight:
39438.355 Da
References
  1. Storey RF: The P2Y12 receptor as a therapeutic target in cardiovascular disease. Platelets. 2001 Jun;12(4):197-209. [PubMed:11454254 ]
  2. Boeynaems JM, van Giezen H, Savi P, Herbert JM: P2Y receptor antagonists in thrombosis. Curr Opin Investig Drugs. 2005 Mar;6(3):275-82. [PubMed:15816504 ]
  3. Gachet C: The platelet P2 receptors as molecular targets for old and new antiplatelet drugs. Pharmacol Ther. 2005 Nov;108(2):180-92. Epub 2005 Jun 13. [PubMed:15955565 ]
  4. Zhan C, Yang J, Dong XC, Wang YL: Molecular modeling of purinergic receptor P2Y12 and interaction with its antagonists. J Mol Graph Model. 2007 Jul;26(1):20-31. Epub 2006 Sep 26. [PubMed:17110146 ]
  5. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Peroxidase activity
Specific Function:
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
Gene Name:
MPO
Uniprot ID:
P05164
Molecular Weight:
83867.71 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Vitamin d 24-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP1A1
Uniprot ID:
P04798
Molecular Weight:
58164.815 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
References
  1. Walsky RL, Astuccio AV, Obach RS: Evaluation of 227 drugs for in vitro inhibition of cytochrome P450 2B6. J Clin Pharmacol. 2006 Dec;46(12):1426-38. [PubMed:17101742 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Gene Name:
CYP2E1
Uniprot ID:
P05181
Molecular Weight:
56848.42 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Comments
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23