Identification

Name
Clopidogrel
Accession Number
DB00758  (APRD00444)
Type
Small Molecule
Groups
Approved, Nutraceutical
Description

Clopidogrel, an antiplatelet agent structurally and pharmacologically similar to ticlopidine, is used to inhibit blood clots in a variety of conditions such as peripheral vascular disease, coronary artery disease, and cerebrovascular disease. Clopidogrel is sold under the name Plavix by Sanofi and Bristol-Myers Squibb. The drug is an irreversible inhibitor of the P2Y12 adenosine diphosphate receptor found on the membranes of platelet cells. Clopidogrel use is associated with several serious adverse drug reactions such as severe neutropenia, various forms of hemorrhage, and cardiovascular edema.

Structure
Thumb
Synonyms
  • (+)-Clopidogrel
  • Clopidogrelum
External IDs
R 130964 / R-130964 / SR 25990 / SR-25990 / SR-25990C
Product Ingredients
IngredientUNIICASInChI Key
Clopidogrel Bisulfate08I79HTP27120202-66-6FDEODCTUSIWGLK-RSAXXLAASA-N
Product Images
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Abbott-clopidogrelTablet75 mgOralAbbott2014-03-172015-12-31Canada
Accel-clopidogrelTablet75 mgOralAccel Pharma Inc2014-09-042015-11-09Canada
Accel-clopidogrelTablet300 mgOralAccel Pharma IncNot applicableNot applicableCanada
Act ClopidogrelTablet75 mgOralActavis Pharma Company2011-12-07Not applicableCanada
Ag-clopidogrelTablet75 mgOralAngita Pharma Inc.Not applicableNot applicableCanada
Auro-clopidogrelTablet75 mgOralAuro Pharma Inc2014-02-06Not applicableCanada
Bio-clopidogrelTablet75 mgOralBiomed PharmaNot applicableNot applicableCanada
ClopidogrelTablet75 mgOralSivem Pharmaceuticals Ulc2012-06-11Not applicableCanada
ClopidogrelTablet75 mgOralSanis Health Inc2013-02-13Not applicableCanada
ClopidogrelTablet75 mgOralPro Doc Limitee2012-11-22Not applicableCanada
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-clopidogrelTablet75 mgOralApotex Corporation2011-12-19Not applicableCanada
Apo-clopidogrelTablet300 mgOralApotex Corporation2013-01-21Not applicableCanada
Clopidogre RatiopharmTablet, film coated75 mgOralTeva B.V.2015-02-19Not applicableEu
ClopidogrelTablet, film coated75 mg/1OralState of Florida DOH Central Pharmacy2014-11-01Not applicableUs
ClopidogrelTablet, film coated75 mg/1OralWockhardt2012-05-22Not applicableUs
ClopidogrelTablet, film coated75 mg/1OralA S Medication Solutions2012-05-172017-06-20Us
ClopidogrelTablet75 mg/1OralRemedy Repack2017-04-05Not applicableUs
ClopidogrelTablet, film coated75 mg/1OralDirectrx2014-01-01Not applicableUs
ClopidogrelTablet, film coated75 mg/1Oralbryant ranch prepack2012-05-17Not applicableUs
ClopidogrelTablet, film coated75 mg/1OralApotex Corporation2012-05-17Not applicableUs
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Clopido Grel 1a PharmaTablet, film coated75 mgOralAcino Pharma Gmb H2009-07-28Not applicableEu
ClopidogrelTablet, film coated75 mg/1OralNu Care Pharmaceuticals,inc.2012-05-17Not applicableUs
Clopidogrel 1a PharmaTablet, film coated75 mgOralAcino Pharma Gmb H2009-07-28Not applicableEu
Clopidogrel 1a PharmaTablet, film coated75 mgOralAcino Pharma Gmb H2009-07-28Not applicableEu
Clopidogrel 1a PharmaTablet, film coated75 mgOralAcino Pharma Gmb H2009-07-28Not applicableEu
Clopidogrel 1a PharmaTablet, film coated75 mgOralAcino Pharma Gmb H2009-07-28Not applicableEu
Clopidogrel 1a PharmaTablet, film coated75 mgOralAcino Pharma Gmb H2009-07-28Not applicableEu
Clopidogrel 1a PharmaTablet, film coated75 mgOralAcino Pharma Gmb H2009-07-28Not applicableEu
Clopidogrel Acino Pharma GmbhTablet, film coated75 mgOralAcino Pharma Gmb H2009-09-21Not applicableEu
Clopidogrel Acino Pharma GmbhTablet, film coated75 mgOralAcino Pharma Gmb H2009-09-21Not applicableEu
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
DuoplavinClopidogrel (75 mg) + Acetylsalicylic acid (75 mg)Tablet, film coatedOralSanofi Pharma Bristol Myers Squibb Snc2010-03-15Not applicableEu
DuoplavinClopidogrel (75 mg) + Acetylsalicylic acid (100 mg)Tablet, film coatedOralSanofi Pharma Bristol Myers Squibb Snc2010-03-15Not applicableEu
DuoplavinClopidogrel (75 mg) + Acetylsalicylic acid (100 mg)Tablet, film coatedOralSanofi Pharma Bristol Myers Squibb Snc2010-03-15Not applicableEu
DuoplavinClopidogrel (75 mg) + Acetylsalicylic acid (75 mg)Tablet, film coatedOralSanofi Pharma Bristol Myers Squibb Snc2010-03-15Not applicableEu
DuoplavinClopidogrel (75 mg) + Acetylsalicylic acid (100 mg)Tablet, film coatedOralSanofi Pharma Bristol Myers Squibb Snc2010-03-15Not applicableEu
DuoplavinClopidogrel (75 mg) + Acetylsalicylic acid (75 mg)Tablet, film coatedOralSanofi Pharma Bristol Myers Squibb Snc2010-03-15Not applicableEu
DuoplavinClopidogrel (75 mg) + Acetylsalicylic acid (75 mg)Tablet, film coatedOralSanofi Pharma Bristol Myers Squibb Snc2010-03-15Not applicableEu
DuoplavinClopidogrel (75 mg) + Acetylsalicylic acid (100 mg)Tablet, film coatedOralSanofi Pharma Bristol Myers Squibb Snc2010-03-15Not applicableEu
DuoplavinClopidogrel (75 mg) + Acetylsalicylic acid (100 mg)Tablet, film coatedOralSanofi Pharma Bristol Myers Squibb Snc2010-03-15Not applicableEu
DuoplavinClopidogrel (75 mg) + Acetylsalicylic acid (75 mg)Tablet, film coatedOralSanofi Pharma Bristol Myers Squibb Snc2010-03-15Not applicableEu
Categories
UNII
A74586SNO7
CAS number
113665-84-2
Weight
Average: 321.822
Monoisotopic: 321.059027158
Chemical Formula
C16H16ClNO2S
InChI Key
GKTWGGQPFAXNFI-HNNXBMFYSA-N
InChI
InChI=1S/C16H16ClNO2S/c1-20-16(19)15(12-4-2-3-5-13(12)17)18-8-6-14-11(10-18)7-9-21-14/h2-5,7,9,15H,6,8,10H2,1H3/t15-/m0/s1
IUPAC Name
methyl (2S)-2-(2-chlorophenyl)-2-{4H,5H,6H,7H-thieno[3,2-c]pyridin-5-yl}acetate
SMILES
[H][[email protected]@](N1CCC2=C(C1)C=CS2)(C(=O)OC)C1=CC=CC=C1Cl

Pharmacology

Indication

For the reduction of atherosclerotic events (myocardial infarction, stroke, and vascular death) in patients with atherosclerosis documented by recent stroke, recent myocardial infarction, or established peripheral arterial disease.

Structured Indications
Pharmacodynamics

Since clopidogrel is a prodrug, it must be metabolized by CYP450 enzymes to produce the active metabolite that inhibits platelet aggregation. This active metabolite selectively inhibits adenosine diphosphate (ADP) binding to its platelet P2Y12 receptor and subsequently the ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation.

Mechanism of action

The active metabolite of clopidogrel prevents binding of adenosine diphosphate (ADP) to its platelet receptor, impairing the ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. It is proposed that the inhibition involves a defect in the mobilization from the storage sites of the platelet granules to the outer membrane. he drug specifically and irreversibly inhibits the P2Y12 subtype of ADP receptor, which is important in aggregation of platelets and cross-linking by the protein fibrin. No direct interference occurs with the GPIIb/IIIa receptor. As the glycoprotein GPIIb/IIIa complex is the major receptor for fibrinogen, its impaired activation prevents fibrinogen binding to platelets and inhibits platelet aggregation. By blocking the amplification of platelet activation by released ADP, platelet aggregation induced by agonists other than ADP is also inhibited by the active metabolite of clopidogrel.

TargetActionsOrganism
AP2Y purinoceptor 12
antagonist
Human
Absorption

Absorption is at least 50% based on urinary excretion of clopidogrel-related metabolites. Bioavailability has not been found to be affected by food.

Volume of distribution
Not Available
Protein binding

98%

Metabolism

Hepatic, extensive and rapid, by hydrolysis to the main circulating metabolite, a carboxylic acid derivative, which accounts for approximately 85% of the circulating drug-related compounds. A glucuronic acid derivative of the carboxylic acid derivative has also been found in plasma and urine. Neither the parent compound nor the carboxylic acid derivative has a platelet inhibiting effect.

Route of elimination

Following an oral dose of 14C-labeled clopidogrel in humans, approximately 50% of total radioactivity was excreted in urine and approximately 46% in feces over the 5 days post-dosing.

Half life

Carboxylic acid derivative: 8 hours (after single and multiple doses). Covalent binding to platelets has accounted for 2% of radiolabeled clopidogrel with a half-life of 11 days.

Clearance
Not Available
Toxicity

A single dose of clopidogrel at 1500 or 2000 mg/kg was lethal to mice and rats, with 3000 mg/kg lethal to baboons. Symptoms included vomiting, breathing difficulty, hemorrhage, and prostration.

Affected organisms
  • Humans and other mammals
Pathways
PathwayCategory
Clopidogrel Action PathwayDrug action
Clopidogrel Metabolism PathwayDrug metabolism
Pharmacogenomic Effects/ADRs
Interacting Gene/EnzymeAllele nameGenotype(s)Defining Change(s)Type(s)DescriptionDetails
Cytochrome P450 2C9CYP2C9*3(C;C) / (A;C)C AlleleEffect Directly StudiedPatients with this genotype have reduced metabolism of clopidogrel resulting in reduced plasma concentrations of its active metabolite.Details
Cytochrome P450 2C19CYP2C19*2(A;A) / (A;G)G > AEffect Directly StudiedPatients with this genotype have reduced metabolism of clopidogrel resulting in reduced plasma concentrations of its active metabolite.Details
Cytochrome P450 2C19CYP2C19*2Not Available681G>AADR Directly StudiedPatients with this polymorphism in CYP2C19 are poor metabolizers of clopidogrel and are associated with diminished platelet response and increased risk of adverse cardiovascular events in response to clopidogrel therapy.Details
Cytochrome P450 2C19CYP2C19*3Not Available636G>ADirectly Studied EffectThe presence of this polymorphism in CYP2C19 is associated with reduced or poor metabolism of clopidogrel.Details
Cytochrome P450 2C19CYP2C19*2ANot Available681G>AADR InferredPoor drug metabolizer, increased risk for adverse cardiovascular events and lower efficacy. Alternative recommended.Details
Cytochrome P450 2C19CYP2C19*2BNot Available681G>AADR InferredPoor drug metabolizer, increased risk for adverse cardiovascular events and lower efficacy. Alternative recommended.Details
Cytochrome P450 2C19CYP2C19*4Not Available1A>GADR InferredPoor drug metabolizer, increased risk for adverse cardiovascular events and lower efficacy. Alternative recommended.Details
Cytochrome P450 2C19CYP2C19*5Not Available1297C>TADR InferredPoor drug metabolizer, increased risk for adverse cardiovascular events and lower efficacy. Alternative recommended.Details
Cytochrome P450 2C19CYP2C19*6Not Available395G>AADR InferredPoor drug metabolizer, increased risk for adverse cardiovascular events and lower efficacy. Alternative recommended.Details
Cytochrome P450 2C19CYP2C19*7Not Available19294T>AADR InferredPoor drug metabolizer, increased risk for adverse cardiovascular events and lower efficacy. Alternative recommended.Details
Cytochrome P450 2C19CYP2C19*22Not Available557G>C / 991A>GADR InferredPoor drug metabolizer, increased risk for adverse cardiovascular events and lower efficacy. Alternative recommended.Details
Cytochrome P450 2C19CYP2C19*24Not Available99C>T / 991A>G  … show all ADR InferredPoor drug metabolizer, increased risk for adverse cardiovascular events and lower efficacy. Alternative recommended.Details
Cytochrome P450 2C19CYP2C19*35Not Available12662A>GADR InferredPoor drug metabolizer, increased risk for adverse cardiovascular events and lower efficacy. Alternative recommended.Details
Cytochrome P450 2C9CYP2C9*6Not Available818delAEffect InferredPoor drug metabolizer, lower dose requirements, higher risk for drug-drug interactionsDetails
Cytochrome P450 2C9CYP2C9*15Not Available485C>AEffect InferredPoor drug metabolizer, lower dose requirements, higher risk for drug-drug interactionsDetails
Cytochrome P450 2C9CYP2C9*25Not Available353_362delAGAAATGGAAEffect InferredPoor drug metabolizer, lower dose requirements, higher risk for drug-drug interactionsDetails
Cytochrome P450 2C9CYP2C9*35Not Available374G>T / 430C>TEffect InferredPoor drug metabolizer, lower dose requirements, higher risk for drug-drug interactionsDetails
Cytochrome P450 2C9CYP2C9*2Not Available430C>TEffect InferredPoor drug metabolizer, lower dose requirements, higher risk for drug-drug interactionsDetails
Cytochrome P450 2C9CYP2C9*4Not Available1076T>CEffect InferredPoor drug metabolizer, lower dose requirements, higher risk for drug-drug interactionsDetails
Cytochrome P450 2C9CYP2C9*5Not Available1080C>GEffect InferredPoor drug metabolizer, lower dose requirements, higher risk for drug-drug interactionsDetails
Cytochrome P450 2C9CYP2C9*8Not Available449G>AEffect InferredPoor drug metabolizer, lower dose requirements, higher risk for drug-drug interactionsDetails
Cytochrome P450 2C9CYP2C9*11Not Available1003C>TEffect InferredPoor drug metabolizer, lower dose requirements, higher risk for drug-drug interactionsDetails
Cytochrome P450 2C9CYP2C9*12Not Available1465C>TEffect InferredPoor drug metabolizer, lower dose requirements, higher risk for drug-drug interactionsDetails
Cytochrome P450 2C9CYP2C9*13Not Available269T>CEffect InferredPoor drug metabolizer, lower dose requirements, higher risk for drug-drug interactionsDetails
Cytochrome P450 2C9CYP2C9*14Not Available374G>AEffect InferredPoor drug metabolizer, lower dose requirements, higher risk for drug-drug interactionsDetails
Cytochrome P450 2C9CYP2C9*16Not Available895A>GEffect InferredPoor drug metabolizer, lower dose requirements, higher risk for drug-drug interactionsDetails
Cytochrome P450 2C9CYP2C9*18Not Available1075A>C / 1190A>C  … show all Effect InferredPoor drug metabolizer, lower dose requirements, higher risk for drug-drug interactionsDetails
Cytochrome P450 2C9CYP2C9*26Not Available389C>GEffect InferredPoor drug metabolizer, lower dose requirements, higher risk for drug-drug interactionsDetails
Cytochrome P450 2C9CYP2C9*28Not Available641A>TEffect InferredPoor drug metabolizer, lower dose requirements, higher risk for drug-drug interactionsDetails
Cytochrome P450 2C9CYP2C9*30Not Available1429G>AEffect InferredPoor drug metabolizer, lower dose requirements, higher risk for drug-drug interactionsDetails
Cytochrome P450 2C9CYP2C9*33Not Available395G>AEffect InferredPoor drug metabolizer, lower dose requirements, higher risk for drug-drug interactionsDetails
Cytochrome P450 2C19CYP2C19*2ANot Available681G>AEffect InferredPoor drug metabolizer, lower dose requirements, higher risk for drug-drug interactionsDetails
Cytochrome P450 2C19CYP2C19*2BNot Available681G>AEffect InferredPoor drug metabolizer, lower dose requirements, higher risk for drug-drug interactionsDetails
Cytochrome P450 2C19CYP2C19*3Not Available636G>AEffect InferredPoor drug metabolizer, lower dose requirements, higher risk for drug-drug interactionsDetails
Cytochrome P450 2C19CYP2C19*4Not Available1A>GEffect InferredPoor drug metabolizer, lower dose requirements, higher risk for drug-drug interactionsDetails
Cytochrome P450 2C19CYP2C19*5Not Available1297C>TEffect InferredPoor drug metabolizer, lower dose requirements, higher risk for drug-drug interactionsDetails
Cytochrome P450 2C19CYP2C19*6Not Available395G>AEffect InferredPoor drug metabolizer, lower dose requirements, higher risk for drug-drug interactionsDetails
Cytochrome P450 2C19CYP2C19*7Not Available19294T>AEffect InferredPoor drug metabolizer, lower dose requirements, higher risk for drug-drug interactionsDetails
Cytochrome P450 2C19CYP2C19*22Not Available557G>C / 991A>GEffect InferredPoor drug metabolizer, lower dose requirements, higher risk for drug-drug interactionsDetails
Cytochrome P450 2C19CYP2C19*24Not Available99C>T / 991A>G  … show all Effect InferredPoor drug metabolizer, lower dose requirements, higher risk for drug-drug interactionsDetails
Cytochrome P450 2C19CYP2C19*35Not Available12662A>GEffect InferredPoor drug metabolizer, lower dose requirements, higher risk for drug-drug interactionsDetails

Interactions

Drug Interactions
DrugInteractionDrug group
AbciximabClopidogrel may increase the anticoagulant activities of Abciximab.Approved
AbirateroneThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Abiraterone resulting in a loss in efficacy.Approved
AcenocoumarolClopidogrel may increase the anticoagulant activities of Acenocoumarol.Approved
AcetaminophenThe serum concentration of Clopidogrel can be increased when it is combined with Acetaminophen.Approved
Acetylsalicylic acidThe risk or severity of adverse effects can be increased when Clopidogrel is combined with Acetylsalicylic acid.Approved, Vet Approved
AfatinibThe serum concentration of Clopidogrel can be increased when it is combined with Afatinib.Approved
AlbendazoleThe serum concentration of Clopidogrel can be increased when it is combined with Albendazole.Approved, Vet Approved
AldosteroneThe serum concentration of Clopidogrel can be decreased when it is combined with Aldosterone.Experimental, Investigational
AlectinibThe serum concentration of Clopidogrel can be increased when it is combined with Alectinib.Approved
AlfentanilThe serum concentration of Clopidogrel can be increased when it is combined with Alfentanil.Approved, Illicit
AloxiprinThe risk or severity of adverse effects can be increased when Clopidogrel is combined with Aloxiprin.Experimental
AlprostadilAlprostadil may increase the anticoagulant activities of Clopidogrel.Approved, Investigational
AlteplaseClopidogrel may increase the anticoagulant activities of Alteplase.Approved
ALX-0081Clopidogrel may increase the anticoagulant activities of ALX-0081.Investigational
AmantadineThe serum concentration of Clopidogrel can be increased when it is combined with Amantadine.Approved
Aminohippuric acidThe serum concentration of Clopidogrel can be increased when it is combined with Aminohippuric acid.Approved, Investigational
Aminosalicylic AcidThe risk or severity of adverse effects can be increased when Clopidogrel is combined with Aminosalicylic Acid.Approved
AmiodaroneThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Amiodarone resulting in a loss in efficacy.Approved, Investigational
AmitriptylineThe serum concentration of Clopidogrel can be increased when it is combined with Amitriptyline.Approved
AmlodipineThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Amlodipine.Approved
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Clopidogrel.Approved, Investigational
AmprenavirThe serum concentration of Clopidogrel can be decreased when it is combined with Amprenavir.Approved
AmrinoneThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Amrinone.Approved
AmsacrineThe serum concentration of Clopidogrel can be increased when it is combined with Amsacrine.Approved
AnagrelideAnagrelide may increase the anticoagulant activities of Clopidogrel.Approved
AncrodClopidogrel may increase the anticoagulant activities of Ancrod.Investigational
AndrographolideAndrographolide may increase the anticoagulant activities of Clopidogrel.Investigational
AnistreplaseClopidogrel may increase the anticoagulant activities of Anistreplase.Approved
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Clopidogrel.Approved
Antithrombin III humanClopidogrel may increase the anticoagulant activities of Antithrombin III human.Approved
ApixabanThe risk or severity of adverse effects can be increased when Clopidogrel is combined with Apixaban.Approved
AprepitantThe serum concentration of Clopidogrel can be increased when it is combined with Aprepitant.Approved, Investigational
AprotininThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Aprotinin.Approved, Withdrawn
ArdeparinClopidogrel may increase the anticoagulant activities of Ardeparin.Approved, Investigational, Withdrawn
ArgatrobanClopidogrel may increase the anticoagulant activities of Argatroban.Approved, Investigational
ArmodafinilThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Armodafinil resulting in a loss in efficacy.Approved, Investigational
ArtemetherThe metabolism of Artemether can be decreased when combined with Clopidogrel.Approved
AstaxanthinClopidogrel may increase the anticoagulant activities of Astaxanthin.Investigational
AstemizoleThe serum concentration of Clopidogrel can be increased when it is combined with Astemizole.Approved, Withdrawn
AtazanavirThe metabolism of Clopidogrel can be decreased when combined with Atazanavir.Approved, Investigational
AtenololThe serum concentration of Clopidogrel can be increased when it is combined with Atenolol.Approved
AtomoxetineThe metabolism of Clopidogrel can be decreased when combined with Atomoxetine.Approved
AtorvastatinThe serum concentration of Clopidogrel can be increased when it is combined with Atorvastatin.Approved
AzelastineThe serum concentration of Clopidogrel can be increased when it is combined with Azelastine.Approved
AzelnidipineThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Azelnidipine.Approved, Investigational
AzimilideThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Azimilide.Investigational
AzithromycinThe serum concentration of Clopidogrel can be increased when it is combined with Azithromycin.Approved
BalsalazideThe risk or severity of adverse effects can be increased when Clopidogrel is combined with Balsalazide.Approved, Investigational
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Clopidogrel.Investigational
BarnidipineThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Barnidipine.Approved
BatroxobinClopidogrel may increase the anticoagulant activities of Batroxobin.Experimental
BecaplerminClopidogrel may increase the anticoagulant activities of Becaplermin.Approved, Investigational
BemiparinClopidogrel may increase the anticoagulant activities of Bemiparin.Approved, Investigational
BencyclaneThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Bencyclane.Experimental
BenidipineThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Benidipine.Approved, Investigational
BenzocaineThe serum concentration of Clopidogrel can be increased when it is combined with Benzocaine.Approved
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Clopidogrel.Approved, Illicit
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Clopidogrel.Approved
BepridilThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Bepridil.Approved, Withdrawn
BeraprostClopidogrel may increase the anticoagulant activities of Beraprost.Investigational
BiperidenThe serum concentration of Clopidogrel can be increased when it is combined with Biperiden.Approved, Investigational
BivalirudinClopidogrel may increase the anticoagulant activities of Bivalirudin.Approved, Investigational
BoceprevirThe metabolism of Clopidogrel can be decreased when combined with Boceprevir.Approved, Withdrawn
BortezomibThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Bortezomib resulting in a loss in efficacy.Approved, Investigational
BosentanThe serum concentration of Clopidogrel can be decreased when it is combined with Bosentan.Approved, Investigational
BosutinibThe serum concentration of Clopidogrel can be increased when it is combined with Bosutinib.Approved
BrinaseClopidogrel may increase the anticoagulant activities of Brinase.Experimental
BrivaracetamThe metabolism of Brivaracetam can be decreased when combined with Clopidogrel.Approved, Investigational
BromocriptineThe serum concentration of Clopidogrel can be increased when it is combined with Bromocriptine.Approved, Investigational
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Clopidogrel.Approved
BuflomedilBuflomedil may increase the anticoagulant activities of Clopidogrel.Experimental
BuprenorphineThe serum concentration of Clopidogrel can be increased when it is combined with Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BupropionThe serum concentration of Bupropion can be increased when it is combined with Clopidogrel.Approved
BuspironeThe serum concentration of Clopidogrel can be increased when it is combined with Buspirone.Approved, Investigational
ButylphthalideButylphthalide may increase the anticoagulant activities of Clopidogrel.Investigational
CabazitaxelThe serum concentration of Clopidogrel can be increased when it is combined with Cabazitaxel.Approved
CaffeineThe serum concentration of Clopidogrel can be increased when it is combined with Caffeine.Approved
CanagliflozinThe serum concentration of Clopidogrel can be increased when it is combined with Canagliflozin.Approved
Candesartan cilexetilThe serum concentration of Clopidogrel can be increased when it is combined with Candesartan.Approved
CangrelorCangrelor may decrease the antiplatelet activities of Clopidogrel.Approved
CapecitabineThe metabolism of Clopidogrel can be decreased when combined with Capecitabine.Approved, Investigational
CaptoprilThe serum concentration of Clopidogrel can be increased when it is combined with Captopril.Approved
CarbamazepineThe metabolism of Clopidogrel can be increased when combined with Carbamazepine.Approved, Investigational
Carbaspirin calciumThe risk or severity of adverse effects can be increased when Clopidogrel is combined with Carbaspirin calcium.Experimental, Investigational
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Clopidogrel.Approved
CarboxyamidotriazoleThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Carboxyamidotriazole.Investigational
CaroverineThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Caroverine.Experimental
CarvedilolThe serum concentration of Clopidogrel can be increased when it is combined with Carvedilol.Approved, Investigational
CaspofunginThe serum concentration of Clopidogrel can be increased when it is combined with Caspofungin.Approved
CeritinibThe serum concentration of Clopidogrel can be increased when it is combined with Ceritinib.Approved
CertoparinClopidogrel may increase the anticoagulant activities of Certoparin.Approved, Investigational
ChloramphenicolThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Chloramphenicol resulting in a loss in efficacy.Approved, Vet Approved
ChloroquineThe serum concentration of Clopidogrel can be increased when it is combined with Chloroquine.Approved, Vet Approved
ChlorpromazineThe serum concentration of Clopidogrel can be increased when it is combined with Chlorpromazine.Approved, Vet Approved
ChlorpropamideThe serum concentration of Clopidogrel can be increased when it is combined with Chlorpropamide.Approved
ChlorprothixeneThe serum concentration of Clopidogrel can be increased when it is combined with Chlorprothixene.Approved, Investigational, Withdrawn
CholecalciferolThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Cholecalciferol resulting in a loss in efficacy.Approved, Nutraceutical
CholesterolThe serum concentration of Clopidogrel can be increased when it is combined with Cholesterol.Experimental, Investigational
Cholic AcidThe serum concentration of Clopidogrel can be decreased when it is combined with Cholic Acid.Approved
CilazaprilThe serum concentration of Clopidogrel can be increased when it is combined with Cilazapril.Approved
CilnidipineThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Cilnidipine.Approved, Investigational
CilostazolClopidogrel may increase the anticoagulant activities of Cilostazol.Approved
CimetidineThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Cimetidine resulting in a loss in efficacy.Approved
CinnarizineThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Cinnarizine.Approved, Investigational
CiprofloxacinThe serum concentration of Clopidogrel can be increased when it is combined with Ciprofloxacin.Approved, Investigational
CisaprideThe metabolism of Cisapride can be decreased when combined with Clopidogrel.Approved, Investigational, Withdrawn
CitalopramThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Citalopram resulting in a loss in efficacy.Approved
Citric AcidClopidogrel may increase the anticoagulant activities of Citric Acid.Approved, Nutraceutical, Vet Approved
ClarithromycinThe metabolism of Clopidogrel can be decreased when combined with Clarithromycin.Approved
ClemastineThe metabolism of Clopidogrel can be decreased when combined with Clemastine.Approved
ClevidipineThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Clevidipine.Approved
ClobazamThe metabolism of Clobazam can be decreased when combined with Clopidogrel.Approved, Illicit
ClofazimineThe serum concentration of Clopidogrel can be increased when it is combined with Clofazimine.Approved, Investigational
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Clopidogrel.Investigational
ClomipramineThe serum concentration of Clopidogrel can be increased when it is combined with Clomipramine.Approved, Vet Approved
CloricromenClopidogrel may increase the anticoagulant activities of Cloricromen.Experimental
ClorindioneClopidogrel may increase the anticoagulant activities of Clorindione.Experimental
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Clopidogrel.Approved, Illicit
ClotrimazoleThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Clotrimazole resulting in a loss in efficacy.Approved, Vet Approved
CobicistatThe metabolism of Clopidogrel can be decreased when combined with Cobicistat.Approved
ColchicineThe serum concentration of Clopidogrel can be increased when it is combined with Colchicine.Approved
ColforsinThe serum concentration of Clopidogrel can be increased when it is combined with Colforsin.Experimental, Investigational
Collagenase clostridium histolyticumThe risk or severity of adverse effects can be increased when Clopidogrel is combined with Collagenase clostridium histolyticum.Approved, Investigational
ConivaptanThe serum concentration of Clopidogrel can be increased when it is combined with Conivaptan.Approved, Investigational
CrisaboroleThe metabolism of Clopidogrel can be decreased when combined with Crisaborole.Approved
CrizotinibThe metabolism of Clopidogrel can be decreased when combined with Crizotinib.Approved
CyclophosphamideThe serum concentration of Clopidogrel can be increased when it is combined with Cyclophosphamide.Approved, Investigational
CyclosporineThe metabolism of Clopidogrel can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
Cyproterone acetateThe serum concentration of Clopidogrel can be decreased when it is combined with Cyproterone acetate.Approved, Investigational
Dabigatran etexilateClopidogrel may increase the anticoagulant activities of Dabigatran etexilate.Approved
DabrafenibThe serum concentration of Clopidogrel can be decreased when it is combined with Dabrafenib.Approved
DaclatasvirThe serum concentration of Clopidogrel can be increased when it is combined with Daclatasvir.Approved
DactinomycinThe serum concentration of Clopidogrel can be increased when it is combined with Dactinomycin.Approved
DalteparinClopidogrel may increase the anticoagulant activities of Dalteparin.Approved
DanaparoidClopidogrel may increase the anticoagulant activities of Danaparoid.Approved, Withdrawn
DarexabanClopidogrel may increase the anticoagulant activities of Darexaban.Investigational
DarodipineThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Darodipine.Experimental
DarunavirThe metabolism of Clopidogrel can be decreased when combined with Darunavir.Approved
DasatinibDasatinib may increase the anticoagulant activities of Clopidogrel.Approved, Investigational
DaunorubicinThe serum concentration of Clopidogrel can be decreased when it is combined with Daunorubicin.Approved
DeferasiroxThe serum concentration of Clopidogrel can be decreased when it is combined with Deferasirox.Approved, Investigational
DefibrotideClopidogrel may increase the anticoagulant activities of Defibrotide.Approved, Investigational
DelavirdineThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Delavirdine resulting in a loss in efficacy.Approved
Deoxycholic AcidThe risk or severity of adverse effects can be increased when Clopidogrel is combined with Deoxycholic Acid.Approved
dersalazineThe risk or severity of adverse effects can be increased when Clopidogrel is combined with dersalazine.Investigational
DesipramineThe serum concentration of Clopidogrel can be increased when it is combined with Desipramine.Approved
DesirudinClopidogrel may increase the anticoagulant activities of Desirudin.Approved
DesloratadineThe serum concentration of Clopidogrel can be increased when it is combined with Desloratadine.Approved, Investigational
DesmoteplaseClopidogrel may increase the anticoagulant activities of Desmoteplase.Investigational
DexamethasoneThe serum concentration of Clopidogrel can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DexlansoprazoleThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Dexlansoprazole resulting in a loss in efficacy.Approved
DextranClopidogrel may increase the anticoagulant activities of Dextran.Approved, Vet Approved
Dextran 40Clopidogrel may increase the anticoagulant activities of Dextran 40.Approved
Dextran 70Clopidogrel may increase the anticoagulant activities of Dextran 70.Approved
Dextran 75Clopidogrel may increase the anticoagulant activities of Dextran 75.Approved
DextromethorphanThe serum concentration of Clopidogrel can be increased when it is combined with Dextromethorphan.Approved
DiazepamThe metabolism of Diazepam can be decreased when combined with Clopidogrel.Approved, Illicit, Vet Approved
DiclofenacThe serum concentration of Clopidogrel can be increased when it is combined with Diclofenac.Approved, Vet Approved
DicoumarolClopidogrel may increase the anticoagulant activities of Dicoumarol.Approved
DiflunisalThe risk or severity of adverse effects can be increased when Clopidogrel is combined with Diflunisal.Approved
DigoxinThe serum concentration of Clopidogrel can be decreased when it is combined with Digoxin.Approved
DihydroergotamineThe metabolism of Clopidogrel can be decreased when combined with Dihydroergotamine.Approved
DiltiazemThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Diltiazem.Approved
DiphenadioneClopidogrel may increase the anticoagulant activities of Diphenadione.Experimental
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Clopidogrel.Approved
DipyridamoleThe serum concentration of Clopidogrel can be increased when it is combined with Dipyridamole.Approved
DitazoleClopidogrel may increase the anticoagulant activities of Ditazole.Approved, Withdrawn
DomperidoneThe metabolism of Domperidone can be decreased when combined with Clopidogrel.Approved, Investigational, Vet Approved
DosulepinThe metabolism of Clopidogrel can be decreased when combined with Dosulepin.Approved
DotarizineThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Dotarizine.Investigational
DoxazosinThe serum concentration of Clopidogrel can be increased when it is combined with Doxazosin.Approved
DoxepinThe serum concentration of Clopidogrel can be increased when it is combined with Doxepin.Approved
DoxorubicinThe serum concentration of Clopidogrel can be decreased when it is combined with Doxorubicin.Approved, Investigational
DoxycyclineThe metabolism of Clopidogrel can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Clopidogrel can be increased when it is combined with Dronabinol.Approved, Illicit
DronedaroneThe metabolism of Clopidogrel can be decreased when combined with Dronedarone.Approved
Drotrecogin alfaClopidogrel may increase the anticoagulant activities of Drotrecogin alfa.Approved, Investigational, Withdrawn
Edetic AcidClopidogrel may increase the anticoagulant activities of Edetic Acid.Approved, Vet Approved
EdoxabanClopidogrel may increase the anticoagulant activities of Edoxaban.Approved
EfavirenzThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Efavirenz resulting in a loss in efficacy.Approved, Investigational
EfonidipineThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Efonidipine.Approved
ElbasvirThe serum concentration of Clopidogrel can be increased when it is combined with Elbasvir.Approved
EnalaprilThe serum concentration of Clopidogrel can be increased when it is combined with Enalapril.Approved, Vet Approved
EnasidenibThe serum concentration of Clopidogrel can be increased when it is combined with Enasidenib.Approved
EnoxaparinClopidogrel may increase the anticoagulant activities of Enoxaparin.Approved
EnzalutamideThe serum concentration of Clopidogrel can be decreased when it is combined with Enzalutamide.Approved
EperisoneThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Eperisone.Approved, Investigational
EpinastineThe metabolism of Epinastine can be decreased when combined with Clopidogrel.Approved, Investigational
EplivanserinClopidogrel may increase the anticoagulant activities of Eplivanserin.Investigational
eplivanserineClopidogrel may increase the anticoagulant activities of eplivanserine.Investigational
EpoprostenolEpoprostenol may increase the antiplatelet activities of Clopidogrel.Approved
EptifibatideEptifibatide may increase the anticoagulant activities of Clopidogrel.Approved, Investigational
ErgonovineThe serum concentration of Clopidogrel can be increased when it is combined with Ergonovine.Approved
ErgotamineThe serum concentration of Clopidogrel can be increased when it is combined with Ergotamine.Approved
ErythromycinErythromycin may decrease the antiplatelet activities of Clopidogrel.Approved, Vet Approved
Eslicarbazepine acetateThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Eslicarbazepine acetate resulting in a loss in efficacy.Approved
EsomeprazoleEsomeprazole may decrease the antiplatelet activities of Clopidogrel.Approved, Investigational
EstramustineThe serum concentration of Clopidogrel can be increased when it is combined with Estramustine.Approved
EstriolThe serum concentration of Clopidogrel can be decreased when it is combined with Estriol.Approved, Investigational, Vet Approved
EstroneThe serum concentration of Clopidogrel can be decreased when it is combined with Estrone.Approved
Ethyl biscoumacetateClopidogrel may increase the anticoagulant activities of Ethyl biscoumacetate.Withdrawn
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Clopidogrel.Approved, Illicit
EtoposideThe serum concentration of Clopidogrel can be increased when it is combined with Etoposide.Approved
EtravirineThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Etravirine resulting in a loss in efficacy.Approved
FelodipineThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Felodipine.Approved, Investigational
FendilineThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Fendiline.Withdrawn
FentanylThe serum concentration of Clopidogrel can be increased when it is combined with Fentanyl.Approved, Illicit, Investigational, Vet Approved
Ferulic acidClopidogrel may increase the anticoagulant activities of Ferulic acid.Experimental
FexofenadineThe serum concentration of Clopidogrel can be increased when it is combined with Fexofenadine.Approved
FibrinolysinClopidogrel may increase the anticoagulant activities of Fibrinolysin.Investigational
FidaxomicinThe serum concentration of Clopidogrel can be increased when it is combined with Fidaxomicin.Approved
FloxuridineThe metabolism of Clopidogrel can be decreased when combined with Floxuridine.Approved
FluconazoleThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Fluconazole resulting in a loss in efficacy.Approved
FluindioneClopidogrel may increase the anticoagulant activities of Fluindione.Investigational
FlunarizineThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Flunarizine.Approved
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Clopidogrel.Approved, Illicit
FluorouracilThe metabolism of Clopidogrel can be decreased when combined with Fluorouracil.Approved
FluoxetineThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Fluoxetine resulting in a loss in efficacy.Approved, Vet Approved
FlupentixolThe serum concentration of Clopidogrel can be increased when it is combined with Flupentixol.Approved, Withdrawn
FluphenazineThe serum concentration of Clopidogrel can be increased when it is combined with Fluphenazine.Approved
FlurazepamThe serum concentration of Clopidogrel can be increased when it is combined with Flurazepam.Approved, Illicit
FluvastatinThe metabolism of Clopidogrel can be decreased when combined with Fluvastatin.Approved
FluvoxamineThe risk or severity of adverse effects can be increased when Fluvoxamine is combined with Clopidogrel.Approved, Investigational
FondaparinuxClopidogrel may increase the anticoagulant activities of Fondaparinux.Investigational
Fondaparinux sodiumClopidogrel may increase the anticoagulant activities of Fondaparinux sodium.Approved, Investigational
FosamprenavirThe metabolism of Clopidogrel can be decreased when combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Clopidogrel can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe metabolism of Clopidogrel can be increased when combined with Fosphenytoin.Approved
Fusidic AcidThe serum concentration of Clopidogrel can be increased when it is combined with Fusidic Acid.Approved
GabapentinThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Gabapentin.Approved, Investigational
GabexateClopidogrel may increase the anticoagulant activities of Gabexate.Investigational
GallopamilThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Gallopamil.Investigational
GefitinibThe serum concentration of Clopidogrel can be increased when it is combined with Gefitinib.Approved, Investigational
GemfibrozilThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Gemfibrozil resulting in a loss in efficacy.Approved
GenisteinThe serum concentration of Clopidogrel can be increased when it is combined with Genistein.Investigational
GlecaprevirThe serum concentration of Clopidogrel can be increased when it is combined with Glecaprevir.Approved
GlucosamineGlucosamine may increase the antiplatelet activities of Clopidogrel.Approved
GlyburideThe serum concentration of Clopidogrel can be increased when it is combined with Glyburide.Approved
GlycerinThe serum concentration of Clopidogrel can be increased when it is combined with Glycerin.Approved, Investigational
Gramicidin DThe serum concentration of Clopidogrel can be increased when it is combined with Gramicidin D.Approved
GrepafloxacinThe serum concentration of Clopidogrel can be increased when it is combined with Grepafloxacin.Investigational, Withdrawn
GuacetisalThe risk or severity of adverse effects can be increased when Clopidogrel is combined with Guacetisal.Experimental
HaloperidolThe serum concentration of Clopidogrel can be increased when it is combined with Haloperidol.Approved
HalothaneThe metabolism of Halothane can be decreased when combined with Clopidogrel.Approved, Vet Approved
Hemoglobin crosfumarilThe risk or severity of adverse effects can be increased when Clopidogrel is combined with Hemoglobin crosfumaril.Experimental
HeparinClopidogrel may increase the anticoagulant activities of Heparin.Approved, Investigational
HigenamineClopidogrel may increase the anticoagulant activities of Higenamine.Investigational
HydrocortisoneThe serum concentration of Clopidogrel can be increased when it is combined with Hydrocortisone.Approved, Vet Approved
HydroxytyrosolHydroxytyrosol may increase the anticoagulant activities of Clopidogrel.Investigational
Ibritumomab tiuxetanThe risk or severity of adverse effects can be increased when Clopidogrel is combined with Ibritumomab tiuxetan.Approved
IbrutinibThe risk or severity of adverse effects can be increased when Ibrutinib is combined with Clopidogrel.Approved
IbudilastIbudilast may increase the anticoagulant activities of Clopidogrel.Approved, Investigational
Icosapent ethylIcosapent ethyl may increase the anticoagulant activities of Clopidogrel.Approved, Nutraceutical
IdelalisibThe serum concentration of Clopidogrel can be increased when it is combined with Idelalisib.Approved
IdraparinuxClopidogrel may increase the anticoagulant activities of Idraparinux.Investigational
IfenprodilIfenprodil may increase the anticoagulant activities of Clopidogrel.Approved, Investigational, Withdrawn
IfetrobanIfetroban may increase the anticoagulant activities of Clopidogrel.Investigational
IfosfamideThe metabolism of Ifosfamide can be decreased when combined with Clopidogrel.Approved
IloprostIloprost may increase the antiplatelet activities of Clopidogrel.Approved, Investigational
ImatinibThe metabolism of Clopidogrel can be decreased when combined with Imatinib.Approved
ImipramineThe serum concentration of Clopidogrel can be increased when it is combined with Imipramine.Approved
IndinavirThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Indinavir resulting in a loss in efficacy.Approved
IndobufenClopidogrel may increase the anticoagulant activities of Indobufen.Investigational
IndomethacinThe serum concentration of Clopidogrel can be increased when it is combined with Indomethacin.Approved, Investigational
IrbesartanThe metabolism of Clopidogrel can be decreased when combined with Irbesartan.Approved, Investigational
IrinotecanThe metabolism of Irinotecan can be decreased when combined with Clopidogrel.Approved, Investigational
IsavuconazoniumThe metabolism of Clopidogrel can be decreased when combined with Isavuconazonium.Approved, Investigational
IsofluraneThe metabolism of Isoflurane can be decreased when combined with Clopidogrel.Approved, Vet Approved
IsoniazidThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Isoniazid resulting in a loss in efficacy.Approved
IsradipineThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Isradipine.Approved
ItraconazoleThe metabolism of Clopidogrel can be decreased when combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Clopidogrel can be increased when it is combined with Ivacaftor.Approved
IvermectinThe serum concentration of Clopidogrel can be increased when it is combined with Ivermectin.Approved, Vet Approved
IxazomibThe metabolism of Ixazomib can be decreased when combined with Clopidogrel.Approved
KetamineThe serum concentration of Clopidogrel can be increased when it is combined with Ketamine.Approved, Vet Approved
KetanserinKetanserin may increase the anticoagulant activities of Clopidogrel.Investigational
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Clopidogrel.Approved, Investigational
KetoconazoleThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Ketoconazole resulting in a loss in efficacy.Approved, Investigational
LacidipineThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Lacidipine.Approved, Investigational
LamotrigineThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Lamotrigine.Approved, Investigational
LansoprazoleThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Lansoprazole resulting in a loss in efficacy.Approved, Investigational
LapatinibThe serum concentration of Clopidogrel can be increased when it is combined with Lapatinib.Approved, Investigational
LeflunomideThe metabolism of Clopidogrel can be decreased when combined with Leflunomide.Approved, Investigational
LepirudinClopidogrel may increase the anticoagulant activities of Lepirudin.Approved
LercanidipineThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Lercanidipine.Approved, Investigational
LetaxabanClopidogrel may increase the anticoagulant activities of Letaxaban.Investigational
LevofloxacinThe serum concentration of Clopidogrel can be increased when it is combined with Levofloxacin.Approved, Investigational
LevothyroxineThe serum concentration of Clopidogrel can be decreased when it is combined with Levothyroxine.Approved
LidocaineThe serum concentration of Clopidogrel can be increased when it is combined with Lidocaine.Approved, Vet Approved
LidoflazineThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Lidoflazine.Experimental
LimaprostThe risk or severity of adverse effects can be increased when Limaprost is combined with Clopidogrel.Approved, Investigational
LinsidomineLinsidomine may increase the anticoagulant activities of Clopidogrel.Experimental
LiothyronineThe serum concentration of Clopidogrel can be decreased when it is combined with Liothyronine.Approved, Vet Approved
LiotrixThe serum concentration of Clopidogrel can be decreased when it is combined with Liotrix.Approved
LisinoprilThe serum concentration of Clopidogrel can be increased when it is combined with Lisinopril.Approved, Investigational
LobeglitazoneThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Lobeglitazone resulting in a loss in efficacy.Approved, Investigational
LomitapideThe serum concentration of Clopidogrel can be increased when it is combined with Lomitapide.Approved
LoperamideThe serum concentration of Clopidogrel can be increased when it is combined with Loperamide.Approved
LopinavirThe metabolism of Clopidogrel can be decreased when combined with Lopinavir.Approved
LoratadineThe serum concentration of Clopidogrel can be increased when it is combined with Loratadine.Approved
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Clopidogrel.Approved
LosartanThe serum concentration of Clopidogrel can be increased when it is combined with Losartan.Approved
LovastatinThe metabolism of Clopidogrel can be decreased when combined with Lovastatin.Approved, Investigational
LuliconazoleThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Luliconazole resulting in a loss in efficacy.Approved
LumacaftorThe serum concentration of Clopidogrel can be decreased when it is combined with Lumacaftor.Approved
Magnesium SulfateThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Magnesium Sulfate.Approved, Vet Approved
MalathionThe metabolism of Malathion can be decreased when combined with Clopidogrel.Approved, Investigational
ManidipineThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Manidipine.Approved, Investigational
MaprotilineThe serum concentration of Clopidogrel can be increased when it is combined with Maprotiline.Approved
MebendazoleThe serum concentration of Clopidogrel can be increased when it is combined with Mebendazole.Approved, Vet Approved
MefloquineThe serum concentration of Clopidogrel can be increased when it is combined with Mefloquine.Approved
Megestrol acetateThe serum concentration of Clopidogrel can be increased when it is combined with Megestrol acetate.Approved, Vet Approved
MelagatranClopidogrel may increase the anticoagulant activities of Melagatran.Experimental
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Clopidogrel.Investigational, Withdrawn
MeprobamateThe serum concentration of Clopidogrel can be increased when it is combined with Meprobamate.Approved, Illicit
MesalazineThe risk or severity of adverse effects can be increased when Clopidogrel is combined with Mesalazine.Approved
MethadoneThe serum concentration of Clopidogrel can be increased when it is combined with Methadone.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Clopidogrel.Approved, Investigational, Vet Approved
MethylphenobarbitalThe metabolism of Methylphenobarbital can be decreased when combined with Clopidogrel.Approved
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Clopidogrel.Approved
MetoprololThe serum concentration of Clopidogrel can be increased when it is combined with Metoprolol.Approved, Investigational
MexiletineThe metabolism of Clopidogrel can be decreased when combined with Mexiletine.Approved
MianserinThe metabolism of Mianserin can be decreased when combined with Clopidogrel.Approved, Investigational
MibefradilThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Mibefradil.Investigational, Withdrawn
MiconazoleThe serum concentration of Clopidogrel can be increased when it is combined with Miconazole.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Clopidogrel can be decreased when it is combined with Midazolam.Approved, Illicit
MidostaurinThe metabolism of Clopidogrel can be decreased when combined with Midostaurin.Approved
MifepristoneThe serum concentration of Clopidogrel can be increased when it is combined with Mifepristone.Approved, Investigational
MilrinoneMilrinone may increase the anticoagulant activities of Clopidogrel.Approved
MitomycinThe serum concentration of Clopidogrel can be increased when it is combined with Mitomycin.Approved
MitotaneThe serum concentration of Clopidogrel can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe serum concentration of Clopidogrel can be decreased when it is combined with Mitoxantrone.Approved, Investigational
MoclobemideThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Moclobemide resulting in a loss in efficacy.Approved
ModafinilThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Modafinil resulting in a loss in efficacy.Approved, Investigational
MorphineMorphine may decrease the antiplatelet activities of Clopidogrel.Approved, Investigational
NadroparinClopidogrel may increase the anticoagulant activities of Nadroparin.Approved
NafamostatClopidogrel may increase the anticoagulant activities of Nafamostat.Approved, Investigational
NaftopidilThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Naftopidil.Investigational
NaltrexoneThe serum concentration of Clopidogrel can be increased when it is combined with Naltrexone.Approved, Investigational, Vet Approved
NaringeninThe serum concentration of Clopidogrel can be increased when it is combined with Naringenin.Experimental
NefazodoneThe metabolism of Clopidogrel can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Nelfinavir resulting in a loss in efficacy.Approved
NeostigmineThe serum concentration of Clopidogrel can be increased when it is combined with Neostigmine.Approved, Vet Approved
NetupitantThe serum concentration of Clopidogrel can be increased when it is combined with Netupitant.Approved
NevirapineThe metabolism of Clopidogrel can be increased when combined with Nevirapine.Approved
NicardipineThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Nicardipine resulting in a loss in efficacy.Approved
NicotineThe metabolism of Nicotine can be decreased when combined with Clopidogrel.Approved
NifedipineThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Nifedipine.Approved
NiguldipineThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Niguldipine.Experimental
NilotinibThe metabolism of Clopidogrel can be decreased when combined with Nilotinib.Approved, Investigational
NiludipineThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Niludipine.Experimental
NilvadipineThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Nilvadipine.Approved, Investigational
NimesulideThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Nimesulide.Approved, Investigational, Withdrawn
NimodipineThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Nimodipine.Approved
NisoldipineThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Nisoldipine.Approved
NitrazepamThe serum concentration of Clopidogrel can be increased when it is combined with Nitrazepam.Approved
NitrendipineThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Nitrendipine.Approved, Investigational
NitroaspirinThe risk or severity of adverse effects can be increased when Clopidogrel is combined with Nitroaspirin.Investigational
NorethisteroneThe serum concentration of Clopidogrel can be decreased when it is combined with Norethisterone.Approved
ObinutuzumabThe risk or severity of adverse effects can be increased when Clopidogrel is combined with Obinutuzumab.Approved
OlaparibThe metabolism of Clopidogrel can be decreased when combined with Olaparib.Approved
OlsalazineThe risk or severity of adverse effects can be increased when Clopidogrel is combined with Olsalazine.Approved
Omega-3 fatty acidsOmega-3 fatty acids may increase the antiplatelet activities of Clopidogrel.Approved, Nutraceutical
OmeprazoleOmeprazole may decrease the antiplatelet activities of Clopidogrel.Approved, Investigational, Vet Approved
OsimertinibThe serum concentration of Clopidogrel can be increased when it is combined with Osimertinib.Approved
OspemifeneThe metabolism of Ospemifene can be decreased when combined with Clopidogrel.Approved
OtamixabanClopidogrel may increase the anticoagulant activities of Otamixaban.Investigational
OtiloniumThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Otilonium.Experimental, Investigational
OzagrelClopidogrel may increase the anticoagulant activities of Ozagrel.Investigational
P-NitrophenolThe serum concentration of Clopidogrel can be increased when it is combined with P-Nitrophenol.Experimental
PaclitaxelThe serum concentration of Clopidogrel can be increased when it is combined with Paclitaxel.Approved, Vet Approved
PalbociclibThe serum concentration of Clopidogrel can be increased when it is combined with Palbociclib.Approved
Palmitic AcidThe serum concentration of Clopidogrel can be increased when it is combined with Palmitic Acid.Approved, Experimental
PantoprazoleThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Pantoprazole resulting in a loss in efficacy.Approved
ParnaparinClopidogrel may increase the anticoagulant activities of Parnaparin.Approved, Investigational
ParoxetineThe serum concentration of Clopidogrel can be increased when it is combined with Paroxetine.Approved, Investigational
Peginterferon alfa-2bThe serum concentration of Clopidogrel can be increased when it is combined with Peginterferon alfa-2b.Approved
PentobarbitalThe metabolism of Clopidogrel can be increased when combined with Pentobarbital.Approved, Vet Approved
Pentosan PolysulfateThe risk or severity of adverse effects can be increased when Pentosan Polysulfate is combined with Clopidogrel.Approved
PentoxifyllinePentoxifylline may increase the antiplatelet activities of Clopidogrel.Approved, Investigational
PerhexilineThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Perhexiline.Approved, Investigational
PerindoprilThe serum concentration of Clopidogrel can be increased when it is combined with Perindopril.Approved
PermethrinThe metabolism of Permethrin can be decreased when combined with Clopidogrel.Approved, Investigational
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Clopidogrel.Approved
PethidineThe metabolism of Pethidine can be decreased when combined with Clopidogrel.Approved
PhenindioneClopidogrel may increase the anticoagulant activities of Phenindione.Approved, Investigational
PhenobarbitalThe metabolism of Clopidogrel can be increased when combined with Phenobarbital.Approved
PhenprocoumonClopidogrel may increase the anticoagulant activities of Phenprocoumon.Approved, Investigational
PhenytoinThe metabolism of Clopidogrel can be increased when combined with Phenytoin.Approved, Vet Approved
PibrentasvirThe serum concentration of Clopidogrel can be increased when it is combined with Pibrentasvir.Approved
PicotamideClopidogrel may increase the anticoagulant activities of Picotamide.Experimental
PimozideThe serum concentration of Clopidogrel can be increased when it is combined with Pimozide.Approved
PinaveriumThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Pinaverium.Approved
Platelet Activating FactorThe serum concentration of Clopidogrel can be decreased when it is combined with Platelet Activating Factor.Experimental
PonatinibThe serum concentration of Clopidogrel can be increased when it is combined with Ponatinib.Approved
PosaconazoleThe metabolism of Clopidogrel can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PrasugrelThe metabolism of Prasugrel can be decreased when combined with Clopidogrel.Approved
PravastatinThe serum concentration of Clopidogrel can be increased when it is combined with Pravastatin.Approved
PrazosinThe serum concentration of Clopidogrel can be increased when it is combined with Prazosin.Approved
PrednisoneThe serum concentration of Clopidogrel can be increased when it is combined with Prednisone.Approved, Vet Approved
PregabalinThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Pregabalin.Approved, Illicit, Investigational
PrenylamineThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Prenylamine.Withdrawn
PrimidoneThe metabolism of Clopidogrel can be increased when combined with Primidone.Approved, Vet Approved
ProbenecidThe serum concentration of Clopidogrel can be increased when it is combined with Probenecid.Approved
ProgesteroneThe serum concentration of Clopidogrel can be decreased when it is combined with Progesterone.Approved, Vet Approved
PromethazineThe serum concentration of Clopidogrel can be increased when it is combined with Promethazine.Approved
PropafenoneThe serum concentration of Clopidogrel can be increased when it is combined with Propafenone.Approved
PropofolThe metabolism of Propofol can be decreased when combined with Clopidogrel.Approved, Investigational, Vet Approved
PropranololThe serum concentration of Clopidogrel can be increased when it is combined with Propranolol.Approved, Investigational
Protein CClopidogrel may increase the anticoagulant activities of Protein C.Approved
Protein S humanClopidogrel may increase the anticoagulant activities of Protein S human.Approved
ProtocatechualdehydeClopidogrel may increase the anticoagulant activities of Protocatechualdehyde.Approved
ProtriptylineThe serum concentration of Clopidogrel can be increased when it is combined with Protriptyline.Approved
PyrimethamineThe metabolism of Clopidogrel can be decreased when combined with Pyrimethamine.Approved, Vet Approved
QuazepamThe serum concentration of Clopidogrel can be increased when it is combined with Quazepam.Approved, Illicit
QuercetinThe serum concentration of Clopidogrel can be increased when it is combined with Quercetin.Experimental, Investigational
QuinacrineThe serum concentration of Clopidogrel can be increased when it is combined with Quinacrine.Approved, Investigational
QuinidineThe serum concentration of Clopidogrel can be increased when it is combined with Quinidine.Approved
QuinineThe serum concentration of Clopidogrel can be increased when it is combined with Quinine.Approved
RabeprazoleThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Rabeprazole resulting in a loss in efficacy.Approved, Investigational
RamatrobanRamatroban may increase the anticoagulant activities of Clopidogrel.Investigational
RanitidineThe serum concentration of Clopidogrel can be increased when it is combined with Ranitidine.Approved
RanolazineThe serum concentration of Clopidogrel can be increased when it is combined with Ranolazine.Approved, Investigational
ReboxetineThe serum concentration of Clopidogrel can be increased when it is combined with Reboxetine.Approved, Investigational
RegorafenibThe serum concentration of Clopidogrel can be increased when it is combined with Regorafenib.Approved
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Clopidogrel.Approved, Investigational
ReserpineThe serum concentration of Clopidogrel can be decreased when it is combined with Reserpine.Approved, Investigational
ResveratrolResveratrol may increase the anticoagulant activities of Clopidogrel.Approved, Experimental, Investigational
ReteplaseClopidogrel may increase the anticoagulant activities of Reteplase.Approved
ReviparinClopidogrel may increase the anticoagulant activities of Reviparin.Approved, Investigational
RidogrelRidogrel may increase the anticoagulant activities of Clopidogrel.Approved
RifabutinThe risk or severity of adverse effects can be increased when Rifabutin is combined with Clopidogrel.Approved
RifampicinThe risk or severity of adverse effects can be increased when Rifampicin is combined with Clopidogrel.Approved
RifapentineThe risk or severity of adverse effects can be increased when Rifapentine is combined with Clopidogrel.Approved
RilpivirineThe serum concentration of Clopidogrel can be increased when it is combined with Rilpivirine.Approved
RisedronateThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Risedronate.Approved, Investigational
RitonavirThe metabolism of Clopidogrel can be decreased when combined with Ritonavir.Approved, Investigational
RivaroxabanClopidogrel may increase the anticoagulant activities of Rivaroxaban.Approved
RolapitantThe serum concentration of Clopidogrel can be increased when it is combined with Rolapitant.Approved
RomidepsinThe metabolism of Romidepsin can be decreased when combined with Clopidogrel.Approved, Investigational
RopiniroleThe metabolism of Clopidogrel can be decreased when combined with Ropinirole.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Clopidogrel.Approved
RosiglitazoneClopidogrel may increase the anticoagulant activities of Rosiglitazone.Approved, Investigational
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Clopidogrel.Approved
Salicylic acidThe risk or severity of adverse effects can be increased when Clopidogrel is combined with Salicylic acid.Approved, Vet Approved
SaquinavirThe metabolism of Clopidogrel can be decreased when combined with Saquinavir.Approved, Investigational
SarpogrelateClopidogrel may increase the anticoagulant activities of Sarpogrelate.Investigational
SaruplaseClopidogrel may increase the anticoagulant activities of Saruplase.Experimental
ScopolamineThe serum concentration of Clopidogrel can be increased when it is combined with Scopolamine.Approved
SecobarbitalThe metabolism of Clopidogrel can be increased when combined with Secobarbital.Approved, Vet Approved
SelegilineThe serum concentration of Clopidogrel can be increased when it is combined with Selegiline.Approved, Investigational, Vet Approved
SelexipagClopidogrel may increase the anticoagulant activities of Selexipag.Approved
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Clopidogrel.Approved
SertralineThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Sertraline resulting in a loss in efficacy.Approved
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Clopidogrel.Approved, Vet Approved
SildenafilThe metabolism of Clopidogrel can be decreased when combined with Sildenafil.Approved, Investigational
SiltuximabThe serum concentration of Clopidogrel can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Clopidogrel can be increased when it is combined with Simeprevir.Approved
SimvastatinThe serum concentration of Clopidogrel can be increased when it is combined with Simvastatin.Approved
SirolimusThe serum concentration of Clopidogrel can be decreased when it is combined with Sirolimus.Approved, Investigational
SorafenibThe serum concentration of Clopidogrel can be increased when it is combined with Sorafenib.Approved, Investigational
SpironolactoneThe serum concentration of Clopidogrel can be increased when it is combined with Spironolactone.Approved
SRT501SRT501 may increase the anticoagulant activities of Clopidogrel.Investigational
St. John's WortThe serum concentration of Clopidogrel can be decreased when it is combined with St. John's Wort.Investigational, Nutraceutical
StaurosporineThe serum concentration of Clopidogrel can be increased when it is combined with Staurosporine.Experimental
StiripentolThe serum concentration of Clopidogrel can be increased when it is combined with Stiripentol.Approved
StreptokinaseClopidogrel may increase the anticoagulant activities of Streptokinase.Approved, Investigational
StreptozocinThe serum concentration of Clopidogrel can be decreased when it is combined with Streptozocin.Approved
SulfadiazineThe metabolism of Clopidogrel can be decreased when combined with Sulfadiazine.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Clopidogrel can be decreased when combined with Sulfamethoxazole.Approved
SulfinpyrazoneThe serum concentration of Clopidogrel can be increased when it is combined with Sulfinpyrazone.Approved
SulfisoxazoleThe metabolism of Clopidogrel can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SulodexideClopidogrel may increase the anticoagulant activities of Sulodexide.Approved, Investigational
SumatriptanThe serum concentration of Clopidogrel can be increased when it is combined with Sumatriptan.Approved, Investigational
SunitinibThe serum concentration of Clopidogrel can be increased when it is combined with Sunitinib.Approved, Investigational
TacrineThe serum concentration of Clopidogrel can be increased when it is combined with Tacrine.Investigational, Withdrawn
TacrolimusThe serum concentration of Clopidogrel can be decreased when it is combined with Tacrolimus.Approved, Investigational
TamoxifenThe serum concentration of Clopidogrel can be decreased when it is combined with Tamoxifen.Approved
Taurocholic AcidThe serum concentration of Clopidogrel can be increased when it is combined with Taurocholic Acid.Experimental
TelaprevirThe metabolism of Clopidogrel can be decreased when combined with Telaprevir.Approved, Withdrawn
TelithromycinThe metabolism of Clopidogrel can be decreased when combined with Telithromycin.Approved
TelmisartanThe serum concentration of Clopidogrel can be increased when it is combined with Telmisartan.Approved, Investigational
TemazepamThe metabolism of Temazepam can be decreased when combined with Clopidogrel.Approved
TemsirolimusThe serum concentration of Clopidogrel can be increased when it is combined with Temsirolimus.Approved
TenecteplaseClopidogrel may increase the anticoagulant activities of Tenecteplase.Approved
Tenofovir disoproxilThe metabolism of Clopidogrel can be decreased when combined with Tenofovir disoproxil.Approved, Investigational
TerazosinThe serum concentration of Clopidogrel can be increased when it is combined with Terazosin.Approved
TerfenadineThe serum concentration of Clopidogrel can be increased when it is combined with Terfenadine.Withdrawn
TeriflunomideThe serum concentration of Clopidogrel can be decreased when it is combined with Teriflunomide.Approved
TerodilineThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Terodiline.Experimental
TesmilifeneThe serum concentration of Clopidogrel can be decreased when it is combined with Tesmilifene.Investigational
TestosteroneThe serum concentration of Clopidogrel can be increased when it is combined with Testosterone.Approved, Investigational
TetrahydropalmatineThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Tetrahydropalmatine.Investigational
TheophyllineThe metabolism of Clopidogrel can be decreased when combined with Theophylline.Approved
ThiotepaThe metabolism of Clopidogrel can be decreased when combined with Thiotepa.Approved
TicagrelorThe serum concentration of Clopidogrel can be increased when it is combined with Ticagrelor.Approved
TiclopidineThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Ticlopidine resulting in a loss in efficacy.Approved
TinzaparinClopidogrel may increase the anticoagulant activities of Tinzaparin.Approved
TioclomarolClopidogrel may increase the anticoagulant activities of Tioclomarol.Experimental
TipranavirTipranavir may increase the antiplatelet activities of Clopidogrel.Approved, Investigational
TirofibanClopidogrel may increase the anticoagulant activities of Tirofiban.Approved
TocilizumabThe serum concentration of Clopidogrel can be decreased when it is combined with Tocilizumab.Approved
TolbutamideThe metabolism of Clopidogrel can be decreased when combined with Tolbutamide.Approved
Tolfenamic AcidThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Tolfenamic Acid.Approved
TolvaptanThe serum concentration of Clopidogrel can be increased when it is combined with Tolvaptan.Approved
TopiramateThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Topiramate resulting in a loss in efficacy.Approved
TopiroxostatThe metabolism of Clopidogrel can be decreased when combined with Topiroxostat.Approved, Investigational
TositumomabThe risk or severity of adverse effects can be increased when Clopidogrel is combined with Tositumomab.Approved, Investigational
TramadolThe metabolism of Tramadol can be decreased when combined with Clopidogrel.Approved, Investigational
TranilastThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Tranilast.Approved, Investigational
TranylcypromineThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Tranylcypromine resulting in a loss in efficacy.Approved
TrapidilTrapidil may increase the anticoagulant activities of Clopidogrel.Approved
TrazodoneThe serum concentration of Clopidogrel can be decreased when it is combined with Trazodone.Approved, Investigational
TreprostinilTreprostinil may increase the antiplatelet activities of Clopidogrel.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be decreased when combined with Clopidogrel.Approved, Investigational, Nutraceutical
TrifluoperazineThe serum concentration of Clopidogrel can be increased when it is combined with Trifluoperazine.Approved
TriflupromazineThe serum concentration of Clopidogrel can be increased when it is combined with Triflupromazine.Approved, Vet Approved
TriflusalClopidogrel may increase the anticoagulant activities of Triflusal.Approved, Investigational
TrimethoprimThe serum concentration of Clopidogrel can be decreased when it is combined with Trimethoprim.Approved, Vet Approved
TrimipramineThe serum concentration of Clopidogrel can be increased when it is combined with Trimipramine.Approved
TroleandomycinThe serum concentration of Clopidogrel can be increased when it is combined with Troleandomycin.Approved
TroxerutinClopidogrel may increase the anticoagulant activities of Troxerutin.Investigational
UrokinaseClopidogrel may increase the anticoagulant activities of Urokinase.Approved, Investigational, Withdrawn
Valproic AcidThe metabolism of Clopidogrel can be decreased when combined with Valproic Acid.Approved, Investigational
ValsartanThe metabolism of Clopidogrel can be decreased when combined with Valsartan.Approved, Investigational
VelpatasvirThe serum concentration of Clopidogrel can be increased when it is combined with Velpatasvir.Approved
VemurafenibThe serum concentration of Clopidogrel can be increased when it is combined with Vemurafenib.Approved
VenlafaxineThe metabolism of Clopidogrel can be decreased when combined with Venlafaxine.Approved
VerapamilThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Verapamil.Approved
VinblastineThe serum concentration of Clopidogrel can be decreased when it is combined with Vinblastine.Approved
VincristineThe serum concentration of Clopidogrel can be decreased when it is combined with Vincristine.Approved, Investigational
VinorelbineThe serum concentration of Clopidogrel can be increased when it is combined with Vinorelbine.Approved, Investigational
VinpocetineThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Vinpocetine.Investigational
Vitamin EVitamin E may increase the antiplatelet activities of Clopidogrel.Approved, Nutraceutical, Vet Approved
VorapaxarClopidogrel may increase the anticoagulant activities of Vorapaxar.Approved
VoriconazoleThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Voriconazole resulting in a loss in efficacy.Approved, Investigational
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Clopidogrel.Approved
VoxilaprevirThe serum concentration of Clopidogrel can be increased when it is combined with Voxilaprevir.Approved
WarfarinClopidogrel may increase the anticoagulant activities of Warfarin.Approved
XimelagatranClopidogrel may increase the anticoagulant activities of Ximelagatran.Approved, Investigational, Withdrawn
XylometazolineThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Xylometazoline.Approved
ZafirlukastThe metabolism of Clopidogrel can be decreased when combined with Zafirlukast.Approved, Investigational
ZiconotideThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Ziconotide.Approved
ZimelidineThe serum concentration of Clopidogrel can be increased when it is combined with Zimelidine.Withdrawn
ZiprasidoneThe metabolism of Clopidogrel can be decreased when combined with Ziprasidone.Approved
ZucapsaicinThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Zucapsaicin resulting in a loss in efficacy.Approved
Food Interactions
Not Available

References

Synthesis Reference

Revital Lifshitz-Liron, "Novel crystal forms III, IV, V, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form I, compositions containing the new forms and methods of administering the new forms." U.S. Patent US20030114479, issued June 19, 2003.

US20030114479
General References
  1. Chan FK, Ching JY, Hung LC, Wong VW, Leung VK, Kung NN, Hui AJ, Wu JC, Leung WK, Lee VW, Lee KK, Lee YT, Lau JY, To KF, Chan HL, Chung SC, Sung JJ: Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding. N Engl J Med. 2005 Jan 20;352(3):238-44. [PubMed:15659723]
  2. Perry CG, Shuldiner AR: Pharmacogenomics of anti-platelet therapy: how much evidence is enough for clinical implementation? J Hum Genet. 2013 Jun;58(6):339-45. doi: 10.1038/jhg.2013.41. Epub 2013 May 23. [PubMed:23697979]
  3. Furlong MT, Savant I, Yuan M, Scott L, Mylott W, Mariannino T, Kadiyala P, Roongta V, Arnold ME: A validated HPLC-MS/MS assay for quantifying unstable pharmacologically active metabolites of clopidogrel in human plasma: application to a clinical pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 May 1;926:36-41. doi: 10.1016/j.jchromb.2013.02.031. Epub 2013 Mar 1. [PubMed:23542721]
External Links
Human Metabolome Database
HMDB05011
KEGG Drug
D00769
PubChem Compound
60606
PubChem Substance
46507295
ChemSpider
54632
BindingDB
50318910
ChEBI
37941
ChEMBL
CHEMBL1771
Therapeutic Targets Database
DAP000178
PharmGKB
PA449053
HET
CGE
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
PDRhealth
PDRhealth Drug Page
Wikipedia
Clopidogrel
ATC Codes
B01AC04 — Clopidogrel
AHFS Codes
  • 20:12.18 — Platelet Aggregation Inhibitors
PDB Entries
3me6 / 4h1n
FDA label
Download (402 KB)
MSDS
Download (57.4 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedTreatmentPeripheral Vascular Disease (PVD)1
0RecruitingBasic ScienceAortic Valve Stenosis / Inflammatory Reaction / Thrombosis1
0RecruitingTreatmentStroke, Ischemic1
1CompletedNot AvailableHealthy Volunteers5
1CompletedNot AvailableHealthy Volunteers / Pharmacodynamic Interaction1
1CompletedNot AvailablePharmacodynamics1
1CompletedNot AvailableThrombosis1
1CompletedBasic ScienceBioequivalence, AUC, Cmax, Pharmacokinetics1
1CompletedBasic ScienceCYP2C19 Genotypes1
1CompletedBasic ScienceCardiovascular Disease (CVD)1
1CompletedBasic ScienceCoronary Artery Disease1
1CompletedBasic ScienceDrug Interactions1
1CompletedBasic ScienceHealthy Volunteers9
1CompletedBasic ScienceInhibition on Platelet Aggregation1
1CompletedTreatmentAcute Coronary Syndromes (ACS)2
1CompletedTreatmentAntiplatelet Effect1
1CompletedTreatmentAtherosclerosis1
1CompletedTreatmentCoronary Artery Disease4
1CompletedTreatmentFasting2
1CompletedTreatmentFocus of Study / Pharmacokinetics and Pharmacodynamics in Healthy Volunteers1
1CompletedTreatmentHealthy Volunteers9
1CompletedTreatmentHealthy Volunteers / Hemostasis1
1CompletedTreatmentHypercholesterolemia, Familial / Mixed hypercholesterolemia1
1CompletedTreatmentMajor Depressive Disorder (MDD)1
1CompletedTreatmentPlatelet Aggregation1
1Enrolling by InvitationScreeningAcute Coronary Syndromes (ACS)1
1RecruitingTreatmentAorta-iliac Segment Lesion (C,D Type by TASC II)1
1RecruitingTreatmentCoronary Artery Disease1
1RecruitingTreatmentHead and Neck Carcinoma1
1RecruitingTreatmentHealthy Volunteers1
1TerminatedHealth Services ResearchComparative Bioavailability of Clopidogrel Tablets1
1TerminatedPreventionHuman Immunodeficiency Virus (HIV)1
1TerminatedTreatmentAcute Coronary Syndromes (ACS)1
1TerminatedTreatmentHealthy Volunteers / Hemostasis1
1Unknown StatusPreventionAcute Coronary Syndromes (ACS)1
1Unknown StatusTreatmentChronic Kidney Disease (CKD)1
1Unknown StatusTreatmentCoronary Artery Disease1
1, 2CompletedTreatmentSystemic Lupus Erythematous1
2CompletedBasic ScienceCoronary Artery Disease1
2CompletedDiagnosticClopidogrel1
2CompletedDiagnosticDiabetes / Retinopathy, Diabetic1
2CompletedDiagnosticDisease Susceptibility1
2CompletedPreventionAtherosclerosis1
2CompletedPreventionCardiovascular Disease (CVD) / Human Immunodeficiency Virus (HIV) / Inflammatory Reaction1
2CompletedPreventionPeptic Ulcers1
2CompletedScreeningAcute Coronary Syndromes (ACS) / Coronary Artery Disease / Heart Diseases / Myocardial Infarction (MI) / Stent Thrombosis1
2CompletedTreatmentAcute Coronary Syndromes (ACS)5
2CompletedTreatmentAcute Coronary Syndromes (ACS) / Coronary Arteriosclerosis1
2CompletedTreatmentAtherosclerosis / Myocardial Infarction (MI) / Myocardial Ischemia1
2CompletedTreatmentBlood Platelet Disorders / Defect, Congenital Heart1
2CompletedTreatmentCardiovascular Disease (CVD) / Heart Diseases1
2CompletedTreatmentChronic Obstructive Pulmonary Disease (COPD) / Coronary Artery Disease1
2CompletedTreatmentCoronary Artery Disease2
2CompletedTreatmentCoronary Artery Disease / Diabetes Mellitus (DM)1
2CompletedTreatmentHead and Neck Carcinoma / Thromboembolism1
2CompletedTreatmentHealthy Volunteers1
2CompletedTreatmentInfection, Human Immunodeficiency Virus I1
2CompletedTreatmentIntermittent Claudication1
2CompletedTreatmentNeoplasms, Breast1
2CompletedTreatmentPercutaneous Coronary Intervention1
2CompletedTreatmentPeripheral Arterial Disease (PAD)1
2CompletedTreatmentPulmonary Hypertension (PH)1
2CompletedTreatmentStable Coronary Artery Disease2
2CompletedTreatmentTransient ischemia attacks1
2Not Yet RecruitingTreatmentAdenosine / Antiplatelet Therapy / Coronary Artery Disease / Platelet Aggregation / Renal Function Abnormal1
2RecruitingTreatmentCarotid Artery Stenosis1
2RecruitingTreatmentCritical Illness1
2RecruitingTreatmentIntracerebral Hemorrhage / Nonvalvular Atrial Fibrillation1
2RecruitingTreatmentStable Angina (SA) / Unstable Angina (UA)1
2TerminatedTreatmentCoronary Artery Disease1
2Unknown StatusBasic ScienceAsthma Bronchial1
2Unknown StatusTreatmentMyocardial Infarction (MI) / Percutaneous Coronary Intervention1
2Unknown StatusTreatmentST Segment Elevation Myocardial Infarction (STEMI)1
2WithdrawnTreatmentPolycythemia Vera (PV)1
2, 3Active Not RecruitingTreatmentAcute Coronary Syndromes (ACS) / Percutaneous Coronary Intervention1
2, 3CompletedDiagnosticPlatelet Reactivity1
2, 3CompletedPreventionStrokes / Transient Ischaemic Attack (TIA)1
2, 3CompletedTreatmentCoronary Artery Disease1
2, 3CompletedTreatmentCoronary Heart Disease (CHD)1
2, 3CompletedTreatmentMyocardial Infarction (MI)1
2, 3CompletedTreatmentMyocardial Infarction (MI) / Strokes1
2, 3CompletedTreatmentPeripheral Vascular Disease (PVD)1
2, 3RecruitingPreventionCoronary Artery Disease1
2, 3RecruitingTreatmentClopidogrel, Poor Metabolism of / Coronary Artery Disease1
2, 3RecruitingTreatmentIschemic Attack, Transient / Strokes1
2, 3RecruitingTreatmentPeripheral Arterial Disease (PAD)1
2, 3RecruitingTreatmentRecurrent Pregnancy Losses1
2, 3TerminatedTreatmentStroke, Ischemic / Transient Ischaemic Attack (TIA)1
2, 3Unknown StatusTreatmentCLOPIDOGREL, POOR METABOLISM of (Disorder)1
2, 3Unknown StatusTreatmentCoronary Artery Disease1
2, 3Unknown StatusTreatmentStroke, Ischemic / Transient Ischaemic Attack (TIA)1
3Active Not RecruitingTreatmentAdenocarcinoma of the Pancreas / Locally Advanced Pancreatic Cancer / Pancreatic Cancer Metastatic1
3Active Not RecruitingTreatmentCoronary Artery Disease1
3CompletedNot AvailableIschaemic Heart Diseases1
3CompletedDiagnosticCoronary Artery Disease / Endothelial Function1
3CompletedHealth Services ResearchPharmacodynamics / Pharmacodynamics of Antiplatelet Agent1
3CompletedPreventionAcute Coronary Syndromes (ACS)2
3CompletedPreventionAtrial Septal Aneurysm / Migraines / Patent Foramen Ovale (PFO) / Stroke, Ischemic1
3CompletedPreventionHemodialysis Fistula Thrombosis / Renal Failure1
3CompletedPreventionMyocardial Infarction (MI) / Stable Angina (SA)1
3CompletedPreventionNSTEACS / Platelet Aggregation Inhibitors1
3CompletedPreventionNonvalvular Atrial Fibrillation / Vascular Risk1
3CompletedPreventionPeripheral Arterial Disease (PAD)1
3CompletedPreventionPeripheral Artery Disease (PAD)1
3CompletedPreventionRenal Failure1
3CompletedPreventionStrokes / Transient Ischaemic Attack (TIA)1
3CompletedTreatmentAcute Coronary Disease / Angina Unstable1
3CompletedTreatmentAcute Coronary Syndromes (ACS)6
3CompletedTreatmentAcute Coronary Syndromes (ACS) / Coronary Arteriosclerosis1
3CompletedTreatmentAcute Coronary Syndromes (ACS) / Coronary Artery Disease1
3CompletedTreatmentAcute Coronary Syndromes (ACS) / Percutaneous Coronary Intervention1
3CompletedTreatmentAcute Coronary Syndromes (ACS) / Unstable Angina (UA)1
3CompletedTreatmentAcute Ischemic Stroke (AIS)1
3CompletedTreatmentAcute Myocardial Infarction (AMI)1
3CompletedTreatmentArterial Occlusive Diseases1
3CompletedTreatmentArteriosclerosis1
3CompletedTreatmentCarotid Artery Dissection / Cervical Artery Dissection / Strokes / Vertebral Artery Dissection1
3CompletedTreatmentCerebrovascular Accidents / Hypertensive1
3CompletedTreatmentChronic Kidney Disease (CKD)1
3CompletedTreatmentChronic Renal Failure (CRF) / Hemodialysis-dependent patients1
3CompletedTreatmentClopidogrel Non-Responsiveness1
3CompletedTreatmentCoronary Artery Bypass Grafting (CABG) Surgery / Coronary Artery Disease1
3CompletedTreatmentCoronary Artery Disease6
3CompletedTreatmentCoronary Artery Disease / Diabetes Mellitus (DM) / Renal Insufficiency,Chronic1
3CompletedTreatmentCoronary Stent Implantation / Platelet Inhibition1
3CompletedTreatmentHeart Defects,Congenital2
3CompletedTreatmentMyocardial Infarction (MI)3
3CompletedTreatmentMyocardial Infarction (MI) / Myocardial Infarction (STEMI) <= 12 Hours / ST Elevation Myocardial Infarction (STEMI)1
3CompletedTreatmentNonvalvular Atrial Fibrillation / Percutaneous Coronary Intervention1
3CompletedTreatmentPlatelet Reactivity1
3CompletedTreatmentThrombosis1
3Not Yet RecruitingTreatmentAortic Valve Stenosis / Intracranial Embolism / Transcatheter Aortic Valve Replacement1
3Not Yet RecruitingTreatmentEndovascular Procedures / Peripheral Arterial Disease (PAD)1
3Not Yet RecruitingTreatmentIntracranial Atherosclerosis1
3Not Yet RecruitingTreatmentNonvalvular Atrial Fibrillation1
3RecruitingDiagnosticAortic Valve Stenosis / Cardiovascular Disease (CVD) / Heart Valve Diseases / Thrombosis / Ventricular Outflow Obstruction1
3RecruitingPreventionAcute Coronary Syndromes (ACS)1
3RecruitingPreventionCoronary Artery Disease1
3RecruitingPreventionNoncardioembolic Cerebral Infarction1
3RecruitingPreventionTranscatheter Aortic Valve Replacement1
3RecruitingTreatmentAcute Coronary Syndromes (ACS)2
3RecruitingTreatmentAcute ST Segment Elevation Myocardial Infarction / Thrombolysis in Myocardial Infarction Flow1
3RecruitingTreatmentCardiovascular Disease (CVD) / Coronary Artery Disease / Myocardial Infarction (MI) / Myocardial Ischemia / Stent Thrombosis1
3RecruitingTreatmentCarotid Artery Occlusion / Middle Cerebral Artery Occlusion / Strokes1
3RecruitingTreatmentCarotid Stenosis1
3RecruitingTreatmentCerebral Aneurysms1
3RecruitingTreatmentChronic Kidney Disease (CKD)1
3RecruitingTreatmentIschemic Attack, Transient1
3RecruitingTreatmentMyocardial Infarction (MI) / ST Segment Elevation Myocardial Infarction (STEMI)1
3RecruitingTreatmentNonvalvular Atrial Fibrillation1
3RecruitingTreatmentPeripheral Arterial Disease (PAD)1
3RecruitingTreatmentStroke, Acute1
3TerminatedPreventionNonvalvular Atrial Fibrillation / Vascular Risk1
3TerminatedTreatmentAcute Coronary Syndromes (ACS) / Atherosclerosis1
3TerminatedTreatmentAcute Coronary Syndromes (ACS) / Coronary Artery Disease / Myocardial Infarction (MI) / Percutaneous Coronary Intervention1
3TerminatedTreatmentAcute Coronary Syndromes (ACS) / Myocardial Infarction (MI)1
3TerminatedTreatmentAd Hoc Percutaneous Coronary Intervention / Chronic, stable Angina pectoris1
3TerminatedTreatmentAngina Pectoris / Silent Ischemia1
3TerminatedTreatmentStrokes1
3Unknown StatusBasic ScienceCardiovascular Disease (CVD) / Polyvascular Disease1
3Unknown StatusPreventionAcute ST Segment Elevation Myocardial Infarction1
3Unknown StatusTreatmentAtherosclerosis1
3Unknown StatusTreatmentCoronary Artery Bypass Grafting (CABG) Surgery / Graft Patency / Hypercoagulability / Thrombosis1
3Unknown StatusTreatmentCoronary Artery Disease2
3Unknown StatusTreatmentCoronary Artery Stenosis / High Post-Treatment Platelet Reactivity / Late Platelet Aggregation / Maximal Platelet Aggregation1
3Unknown StatusTreatmentNon ST Segment Elevation Acute Coronary Syndrome1
3Unknown StatusTreatmentPercutaneous Coronary Intervention / Stable Angina (SA)1
3WithdrawnBasic ScienceCoronary Heart Disease (CHD)1
4Active Not RecruitingPreventionAortic Valve Disorder / Haemorrhage / Major Bleeding / Myocardial Infarction (MI) / Strokes1
4Active Not RecruitingPreventionMigraines1
4Active Not RecruitingTreatmentAcute Coronary Syndromes (ACS) / Angina Pectoris / Cardiovascular Disease (CVD) / Heart Diseases / Myocardial Ischemia1
4Active Not RecruitingTreatmentCoronary Artery Disease4
4Active Not RecruitingTreatmentCoronary Microvascular Perfusion in Patients With Ischemic Heart Disease1
4CompletedNot AvailableCoronary Heart Disease (CHD)1
4CompletedNot AvailableGastroduodenal Ulcers1
4CompletedNot AvailableHealthy Volunteers1
4CompletedBasic ScienceCoronary Artery Disease2
4CompletedBasic ScienceCoronary Artery Disease / Endothelial Dysfunction / Myocardial Ischemia1
4CompletedBasic ScienceDRUG REACTIONS1
4CompletedDiagnosticAcute Myocardial Infarction (AMI)1
4CompletedDiagnosticCoronary Artery Disease / Elective Percutaneous Coronary Intervention1
4CompletedDiagnosticCoronary Artery Stent Thrombosis1
4CompletedDiagnosticCoronary Heart Disease (CHD) / Percutaneous Coronary Intervention1
4CompletedHealth Services ResearchPeripheral Arterial Disease (PAD)1
4CompletedPreventionAortic Valve Disorder / Myocardial Infarction (MI) / Strokes1
4CompletedPreventionAspirin Resistance / Coronary Artery Disease1
4CompletedPreventionCerebral Infarctions1
4CompletedPreventionCoronary Artery Disease2
4CompletedPreventionCoronary Artery Disease / Platelet Aggregation / Platelet Transcriptome1
4CompletedPreventionStrokes1
4CompletedScreeningHealthy Volunteers1
4CompletedSupportive CareCoronary Artery Disease1
4CompletedTreatmentAcute Coronary Syndromes (ACS)8
4CompletedTreatmentAcute Coronary Syndromes (ACS) / Clopidogrel Low Responsiveness / Percutaneous Coronary Intervention1
4CompletedTreatmentAcute Coronary Syndromes (ACS) / Coronary Artery Disease1
4CompletedTreatmentAcute Coronary Syndromes (ACS) / Coronary Artery Disease / Percutaneous Coronary Intervention1
4CompletedTreatmentAcute Coronary Syndromes (ACS) / Ischaemic Heart Diseases1
4CompletedTreatmentAcute Coronary Syndromes (ACS) / Type 2 Diabetes Mellitus1
4CompletedTreatmentAcute Myocardial Infarction (AMI)2
4CompletedTreatmentAngina Pectoris / Atherosclerosis / Coronary Heart Disease (CHD)1
4CompletedTreatmentAntiplatelet Therapy of Coronary Artery Bypass1
4CompletedTreatmentAtherosclerosis / Cerebral Infarctions1
4CompletedTreatmentBMI >27 kg/m2 / Cardiovascular Disease (CVD)1
4CompletedTreatmentBlood Pressures / Endothelial Function / Platelet Function1
4CompletedTreatmentCVD1
4CompletedTreatmentCardiac Arrest / Postresuscitation Syndrome / ST Elevation (STEMI) and Non-ST Elevation (NSTEMI) Myocardial Infarction1
4CompletedTreatmentCardiovascular Disease (CVD)1
4CompletedTreatmentCarotid Stenosis1
4CompletedTreatmentCerebral Infarctions1
4CompletedTreatmentChronic Kidney Disease (CKD) / Stable Angina (SA)1
4CompletedTreatmentCoronary Artery Disease12
4CompletedTreatmentCoronary Artery Disease / Diabetes Mellitus (DM)1
4CompletedTreatmentCoronary Artery Disease / Myocardial Ischemia / Stent Thrombosis1
4CompletedTreatmentCoronary Artery Disease / Type 2 Diabetes Mellitus2
4CompletedTreatmentCoronary Artery Disease / VA Drug Interactions [VA Drug Interaction]1
4CompletedTreatmentCoronary Heart Disease (CHD)3
4CompletedTreatmentCoronary Heart Disease (CHD) / Platelet Aggregation Inhibitors1
4CompletedTreatmentDiabetes Mellitus (DM)1
4CompletedTreatmentDrug Action Increased1
4CompletedTreatmentFibrinolysis / P2Y12 Inhibitor / ST Elevation Myocardial Infarction1
4CompletedTreatmentHealthy Volunteers1
4CompletedTreatmentHeart Failure With Reduced Ejection Fraction (HFrEF)1
4CompletedTreatmentHypertensive1
4CompletedTreatmentInfluence of Aspirin on the Pharmacokinetics/Pharmacodynamics of Clopidogrel / Influence of Genotype of Drug Metabolizing Enzyme or Transporter on the Pharmacokinetics/Pharmacodynamics of Clopidogrel1
4CompletedTreatmentIschaemic Heart Diseases1
4CompletedTreatmentMetabolic Syndromes1
4CompletedTreatmentMyocardial Infarction (MI)1
4CompletedTreatmentNon ST Segment Elevation Myocardial Infarction (NSTEMI) / ST Segment Elevation Myocardial Infarction (STEMI)1
4CompletedTreatmentNon-ST or ST Elevation Acute Coronary Syndromes1
4CompletedTreatmentPeripheral Arterial Disease (PAD)2
4CompletedTreatmentPlaque, Atherosclerotic1
4CompletedTreatmentPlatelet Reactivity1
4CompletedTreatmentSaphenous Vein Graft Atherosclerosis1
4CompletedTreatmentStable Angina (SA)1
4CompletedTreatmentStable Coronary Artery Disease2
4CompletedTreatmentStrokes1
4CompletedTreatmentTransient ischemia attacks1
4Enrolling by InvitationTreatmentCerebral Infarctions / CLOPIDOGREL, POOR METABOLISM of (Disorder)1
4Enrolling by InvitationTreatmentComplete Occlusion of Coronary Artery / Hibernation, Myocardial1
4Not Yet RecruitingBasic ScienceArtery Occlusion / Aspirin Sensitivity / Cardiovascular Disease (CVD) / Clopidogrel, Poor Metabolism of / Coronary Artery Disease / Coronary Heart Disease (CHD) / Heart Diseases / Myocardial Ischemia / Platelet Thrombus / Platelets Dysfunction1
4Not Yet RecruitingBasic ScienceDiabetes1
4Not Yet RecruitingHealth Services ResearchCoronary Artery Disease1
4Not Yet RecruitingPreventionMinor Stroke / Transient Ischaemic Attack (TIA)1
4Not Yet RecruitingTreatmentAcute Coronary Syndromes (ACS)1
4Not Yet RecruitingTreatmentCoronary Angioplasty / NSTEMI - Non-ST Segment Elevation MI / Type 2 Diabetes Mellitus1
4Not Yet RecruitingTreatmentCoronary Artery Disease2
4Not Yet RecruitingTreatmentCoronary Heart Disease (CHD)1
4Not Yet RecruitingTreatmentCritical Limb Ischemia (CLI)1
4Not Yet RecruitingTreatmentEmbolic Stroke1
4Not Yet RecruitingTreatmentInflammatory Reaction / Thrombosis1
4Not Yet RecruitingTreatmentLeft Atrial Appendage Closure / Non-valvular Atrial Fibrillation (NVAF)1
4Not Yet RecruitingTreatmentMigraines1
4RecruitingNot AvailableAcute Coronary Syndromes (ACS)1
4RecruitingBasic ScienceMyocardial Infarction (MI)1
4RecruitingDiagnosticCoronary Artery Disease1
4RecruitingHealth Services ResearchCoronary Artery Disease / Myocardial Infarction (MI) / Peripheral Vascular Disease (PVD)1
4RecruitingHealth Services ResearchPeripheral Artery Disease (PAD) / Stroke, Ischemic / Type 2 Diabetes Mellitus1
4RecruitingPreventionAcute Coronary Syndromes (ACS) / Chronic Kidney Disease (CKD)1
4RecruitingPreventionAtherosclerosis1
4RecruitingTreatmentAcute Coronary Syndromes (ACS) / Cardiovascular Disease (CVD) / Coronary Arteriosclerosis / Myocardial Ischemia1
4RecruitingTreatmentAcute Coronary Syndromes (ACS) / Coronary Artery Disease / Stenosis1
4RecruitingTreatmentAngina Pectoris1
4RecruitingTreatmentAngina Pectoris / Cardiovascular Disease (CVD) / Coronary Artery Disease / Heart Diseases / Infarction / Myocardial Infarction (MI) / Systemic Embolism / Thoracic Pain / Thrombosis / Transient ischemia attacks / Vascular Diseases1
4RecruitingTreatmentAntiplatelet Therapy / Percutaneous Coronary Intervention / Stable Coronary Syndrome / Ticagrelor1
4RecruitingTreatmentAortic Valve Stenosis / Strokes1
4RecruitingTreatmentAtherosclerosis1
4RecruitingTreatmentAtherosclerosis / Coronary Artery Disease / Stents1
4RecruitingTreatmentCardiovascular Mortality / Cerebrovascular Accidents / Hemorrhage / Myocardial Infarction (MI)1
4RecruitingTreatmentChronic Kidney Disease (CKD) / Non ST Segment Elevation Acute Coronary Syndrome1
4RecruitingTreatmentCoronary Artery Disease2
4RecruitingTreatmentCoronary Artery Disease / Diabetes Mellitus (DM) / Myocardial Infarction (MI) / Renal Diseases1
4RecruitingTreatmentCoronary Artery Disease / Nonvalvular Atrial Fibrillation1
4RecruitingTreatmentCoronary Artery Disease / Type 2 Diabetes Mellitus2
4RecruitingTreatmentCoronary Heart Disease (CHD)2
4RecruitingTreatmentCoronary Heart Disease (CHD) / Percutaneous Transluminal Coronary Angioplasty1
4RecruitingTreatmentDiabetes Mellitus (DM) / Myocardial Infarction (MI) / Peripheral Arterial Disease (PAD)1
4RecruitingTreatmentEndothelial Dysfunction / Vascular Inflammation1
4RecruitingTreatmentGastrointestinal Bleedings1
4RecruitingTreatmentHeart Attacks1
4RecruitingTreatmentInfertility Female1
4RecruitingTreatmentIschemic Cerebrovascular Accident1
4RecruitingTreatmentMyocardial Fibrosis1
4RecruitingTreatmentMyocardial Infarction (MI)1
4RecruitingTreatmentNon-ST-elevation Acute Coronary Syndromes / Non-ST-Elevation Myocardial Infarction / Unstable Angina (UA)1
4RecruitingTreatmentPatients Who Are Scheduled to Undergo a PCI (Percutaneous Coronary Intervention) for CTO (Chronic Total Occlusion)1
4RecruitingTreatmentPeripheral Arterial Disease (PAD)1
4RecruitingTreatmentST Elevation Myocardial Infarction / ST Segment Elevation Myocardial Infarction (STEMI)1
4RecruitingTreatmentThrombosis1
4TerminatedTreatmentAcute Coronary Syndromes (ACS) / Cardiovascular Disease (CVD)2
4TerminatedTreatmentCoronary Artery Disease2
4TerminatedTreatmentCoronary Artery Disease / Haemorrhage / Myocardial Ischemia1
4TerminatedTreatmentCoronary Artery Disease / Thrombosis1
4TerminatedTreatmentCoronary Graft Patency1
4TerminatedTreatmentNon ST Segment Elevation Acute Coronary Syndrome1
4TerminatedTreatmentNon-ST Elevation Acute Coronary Syndrome1
4Unknown StatusBasic SciencePeripheral Arterial Disease (PAD)1
4Unknown StatusHealth Services ResearchAcute Coronary Syndromes (ACS) / Acute ST Segment Elevation Myocardial Infarction1
4Unknown StatusPreventionAcute Coronary Syndromes (ACS) / Myocardial Infarction (MI)1
4Unknown StatusPreventionAortic Valve Disorder / Haemorrhage / Myocardial Infarction (MI) / Strokes1
4Unknown StatusPreventionCarotid Stenosis1
4Unknown StatusScreening30 Healthy People1
4Unknown StatusTreatmentAcute Coronary Syndromes (ACS)1
4Unknown StatusTreatmentCoronary Artery Disease5
4Unknown StatusTreatmentCoronary Artery Disease / Nonvalvular Atrial Fibrillation1
4Unknown StatusTreatmentCoronary Heart Disease (CHD) / Diabetes Mellitus (DM)1
4Unknown StatusTreatmentDiabetic Nephropathies / Type 2 Diabetes Mellitus / Vascular Diseases1
4Unknown StatusTreatmentMyocardial Infarction (MI)1
4Unknown StatusTreatmentMyocardial Infarction (MI) / No-Reflow Phenomenon1
4Unknown StatusTreatmentNonvalvular Atrial Fibrillation1
4Unknown StatusTreatmentPatients Who Are Hospitalized and Expected to Undergo PCI for Acute Coronary Syndrome, Including Acute Myocardial Infarction and Unstable Angina1
4Unknown StatusTreatmentPeripheral Arterial Disease (PAD)1
4Unknown StatusTreatmentPrimary Percutaneous Coronary Intervention / ST Elevation Myocardial Infarction (STEMI)1
4Unknown StatusTreatmentST Segment Elevation Myocardial Infarction (STEMI)1
4WithdrawnNot AvailableAcute Coronary Syndromes (ACS) / Coronary Artery Disease1
4WithdrawnTreatmentAcute Myocardial Infarction (AMI)1
4WithdrawnTreatmentAnkle Brachial Index (0.9 or Less) / Arterial Occlusion Disease / Intermittent Claudication / Peripheral Artery Disease (PAD) / Vascular Diseases1
4WithdrawnTreatmentCoronary Artery Disease2
4WithdrawnTreatmentCoronary Heart Disease (CHD) / Non ST Segment Elevation Myocardial Infarction (NSTEMI) / ST Elevation Myocardial Infarction (STEMI) / Stable Angina (SA) / Unstable Angina (UA)1
Not AvailableActive Not RecruitingTreatmentAcute Coronary Syndromes (ACS)1
Not AvailableCompletedNot AvailableAPT(Antiplatelet Therapy) / HOTPR(High on Treat Platelet Reactivity) / PRU(Platelet Reactivity Unit)1
Not AvailableCompletedNot AvailableAcute Coronary Syndromes (ACS) / Clopidogrel / Haemorrhage / Novel Anti-platelets / Ticagrelor1
Not AvailableCompletedNot AvailableAcute Coronary Syndromes (ACS) / Coronary Arteriosclerosis1
Not AvailableCompletedNot AvailableAcute Coronary Syndromes (ACS) / Drug-eluting Stent (DES) / Percutaneous Coronary Intervention1
Not AvailableCompletedNot AvailableCoronary Artery Disease1
Not AvailableCompletedNot AvailableCoronary Heart Disease (CHD) / Ischaemic Heart Diseases / Secondary Preventions / Strokes1
Not AvailableCompletedNot AvailableHealthy Volunteers1
Not AvailableCompletedNot AvailableHip Fractures1
Not AvailableCompletedNot AvailableIschemia, Brain / Ischemic Attack1
Not AvailableCompletedNot AvailablePlatelet Aggregation Inhibitors1
Not AvailableCompletedBasic ScienceBlood Platelets / Clopidogrel1
Not AvailableCompletedBasic ScienceCoronary Artery Disease / Thoracic Pain1
Not AvailableCompletedBasic ScienceEndotoxaemia1
Not AvailableCompletedDiagnosticCLOPIDOGREL, POOR METABOLISM of (Disorder) / Myocardial Ischemia1
Not AvailableCompletedDiagnosticCoronary Artery Disease1
Not AvailableCompletedHealth Services ResearchDrug Interactions1
Not AvailableCompletedPreventionCardiovascular Disease (CVD) / Coronary Heart Disease (CHD) / Heart Diseases1
Not AvailableCompletedTreatmentAcute Coronary Syndromes (ACS)1
Not AvailableCompletedTreatmentAngioplasty / Atherosclerosis1
Not AvailableCompletedTreatmentAnti Platelet Effects1
Not AvailableCompletedTreatmentCarotid Artery Stenosis1
Not AvailableCompletedTreatmentClopidogrel Non-Responsiveness1
Not AvailableCompletedTreatmentCoronary Artery Disease3
Not AvailableCompletedTreatmentCoronary Heart Disease (CHD)1
Not AvailableCompletedTreatmentIschaemic Heart Diseases1
Not AvailableCompletedTreatmentMetabolism of Clopidogrel1
Not AvailableCompletedTreatmentMyocardial Infarction (MI)1
Not AvailableCompletedTreatmentPercutaneous Coronary Intervention1
Not AvailableCompletedTreatmentStable Angina (SA)1
Not AvailableEnrolling by InvitationPreventionCardiovascular Disease (CVD)1
Not AvailableEnrolling by InvitationTreatmentPeripheral Artery Disease (PAD)1
Not AvailableNot Yet RecruitingNot AvailableStroke, Ischemic1
Not AvailableNot Yet RecruitingPreventionIschemic Attack, Transient / Stroke, Acute1
Not AvailableNot Yet RecruitingTreatmentStrokes1
Not AvailableRecruitingNot AvailableAcute Myocardial Infarction (AMI)1
Not AvailableRecruitingNot AvailableAngina Pectoris / Coronary Artery Disease1
Not AvailableRecruitingNot AvailableMCA - Middle Cerebral Artery Dissection1
Not AvailableRecruitingNot AvailablePlatelet Aggregation Onhibitors1
Not AvailableRecruitingBasic ScienceStable Angina (SA)1
Not AvailableRecruitingPreventionComplication of Cardiac Defibrillator / Disorder of Cardiac Pacemaker System / Venous Occlusion1
Not AvailableRecruitingTreatmentAcute Coronary Syndromes (ACS)2
Not AvailableTemporarily Not AvailableNot AvailableCoronary Artery Disease1
Not AvailableTerminatedNot AvailableStrokes1
Not AvailableTerminatedDiagnosticAortic Valve Disorder1
Not AvailableUnknown StatusNot AvailableCarotid Artery Diseases1
Not AvailableUnknown StatusBasic ScienceHealthy Volunteers1
Not AvailableUnknown StatusTreatmentCoronary Artery Disease1
Not AvailableUnknown StatusTreatmentCoronary Artery Disease / PCI- Percutaneous Coronary Intervention / Platelet Aggregation Inhibitors1
Not AvailableUnknown StatusTreatmentHypercholesterolaemia / Thrombosis1
Not AvailableUnknown StatusTreatmentMyocardial Infarction (MI)1
Not AvailableWithdrawnNot AvailableAcute Coronary Syndromes (ACS) / Non ST Elevation Myocardial Infarction / ST Elevation Myocardial Infarction / Unstable Angina (UA)1
Not AvailableWithdrawnPreventionCarotid Artery Injury / Vertebral Artery Injury1

Pharmacoeconomics

Manufacturers
  • Dr reddys laboratories inc
  • Sanofi aventis us llc
Packagers
Dosage forms
FormRouteStrength
TabletOral300 mg/1
Tablet, film coatedOral75 mg
TabletOral75 mg/1
Tablet, film coatedOral300 mg
Tablet, film coatedOral
TabletOral300 mg
TabletOral75 mg
Tablet, film coatedOral300 mg/1
Tablet, film coatedOral75 mg/1
Prices
Unit descriptionCostUnit
Plavix 300 mg tablet24.86USD tablet
Plavix 75 mg tablet9.23USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US4847265No1994-11-172011-11-17Us
CA2334870No2005-03-152019-06-10Canada
CA1336777No1995-08-222012-08-22Canada
US6429210Yes1999-12-102019-12-10Us
US6504030Yes1999-12-102019-12-10Us

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)158 °CNot Available
water solubility50.78 mg/LNot Available
logP2.5Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0118 mg/mLALOGPS
logP3.84ALOGPS
logP4.03ChemAxon
logS-4.4ALOGPS
pKa (Strongest Basic)5.14ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area29.54 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity84.93 m3·mol-1ChemAxon
Polarizability33.19 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+1.0
Blood Brain Barrier+0.9847
Caco-2 permeable+0.5777
P-glycoprotein substrateSubstrate0.6664
P-glycoprotein inhibitor IInhibitor0.6556
P-glycoprotein inhibitor IIInhibitor0.5558
Renal organic cation transporterInhibitor0.6368
CYP450 2C9 substrateNon-substrate0.7407
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.6339
CYP450 1A2 substrateInhibitor0.724
CYP450 2C9 inhibitorNon-inhibitor0.5223
CYP450 2D6 inhibitorInhibitor0.5712
CYP450 2C19 inhibitorInhibitor0.8071
CYP450 3A4 inhibitorNon-inhibitor0.7389
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.9188
Ames testNon AMES toxic0.7112
CarcinogenicityNon-carcinogens0.9597
BiodegradationNot ready biodegradable0.9911
Rat acute toxicity2.4887 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.7548
hERG inhibition (predictor II)Non-inhibitor0.6329
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Download (71.9 KB)
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-qTof , PositiveLC-MS/MSNot Available
MS/MS Spectrum - , positiveLC-MS/MSsplash10-0229-0967000000-6c51c479e90818ec703b
MS/MS Spectrum - , positiveLC-MS/MSsplash10-0a4i-2900000000-be6dbedd4a0c4f60d0dd

Taxonomy

Description
This compound belongs to the class of organic compounds known as alpha amino acid esters. These are ester derivatives of alpha amino acids.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Carboxylic acids and derivatives
Sub Class
Amino acids, peptides, and analogues
Direct Parent
Alpha amino acid esters
Alternative Parents
Thienopyridines / Aralkylamines / Chlorobenzenes / Aryl chlorides / Pyridines and derivatives / Methyl esters / Heteroaromatic compounds / Thiophenes / Trialkylamines / Monocarboxylic acids and derivatives
show 6 more
Substituents
Alpha-amino acid ester / Thienopyridine / Chlorobenzene / Halobenzene / Aralkylamine / Aryl chloride / Aryl halide / Monocyclic benzene moiety / Pyridine / Benzenoid
show 21 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
methyl ester, monochlorobenzenes, thienopyridine (CHEBI:37941)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Antagonist
General Function
Guanyl-nucleotide exchange factor activity
Specific Function
Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation.
Gene Name
P2RY12
Uniprot ID
Q9H244
Uniprot Name
P2Y purinoceptor 12
Molecular Weight
39438.355 Da
References
  1. Dorsam RT, Murugappan S, Ding Z, Kunapuli SP: Clopidogrel: interactions with the P2Y12 receptor and clinical relevance. Hematology. 2003 Dec;8(6):359-65. [PubMed:14668029]
  2. Herbert JM, Savi P: P2Y12, a new platelet ADP receptor, target of clopidogrel. Semin Vasc Med. 2003 May;3(2):113-22. [PubMed:15199474]
  3. Taubert D, Kastrati A, Harlfinger S, Gorchakova O, Lazar A, von Beckerath N, Schomig A, Schomig E: Pharmacokinetics of clopidogrel after administration of a high loading dose. Thromb Haemost. 2004 Aug;92(2):311-6. [PubMed:15269827]
  4. Wang L, Jacobsen SE, Bengtsson A, Erlinge D: P2 receptor mRNA expression profiles in human lymphocytes, monocytes and CD34+ stem and progenitor cells. BMC Immunol. 2004 Aug 3;5:16. [PubMed:15291969]
  5. Wihlborg AK, Wang L, Braun OO, Eyjolfsson A, Gustafsson R, Gudbjartsson T, Erlinge D: ADP receptor P2Y12 is expressed in vascular smooth muscle cells and stimulates contraction in human blood vessels. Arterioscler Thromb Vasc Biol. 2004 Oct;24(10):1810-5. Epub 2004 Aug 12. [PubMed:15308557]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
  7. Gladding P, Webster M, Zeng I, Farrell H, Stewart J, Ruygrok P, Ormiston J, El-Jack S, Armstrong G, Kay P, Scott D, Gunes A, Dahl ML: The pharmacogenetics and pharmacodynamics of clopidogrel response: an analysis from the PRINC (Plavix Response in Coronary Intervention) trial. JACC Cardiovasc Interv. 2008 Dec;1(6):620-7. doi: 10.1016/j.jcin.2008.09.008. [PubMed:19463375]
  8. Savi P, Zachayus JL, Delesque-Touchard N, Labouret C, Herve C, Uzabiaga MF, Pereillo JM, Culouscou JM, Bono F, Ferrara P, Herbert JM: The active metabolite of Clopidogrel disrupts P2Y12 receptor oligomers and partitions them out of lipid rafts. Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):11069-74. Epub 2006 Jul 11. [PubMed:16835302]
  9. van Gestel MA, Heemskerk JW, Slaaf DW, Heijnen VV, Reneman RS, oude Egbrink MG: In vivo blockade of platelet ADP receptor P2Y12 reduces embolus and thrombus formation but not thrombus stability. Arterioscler Thromb Vasc Biol. 2003 Mar 1;23(3):518-23. Epub 2003 Jan 23. [PubMed:12615691]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014]
  2. Saw J, Steinhubl SR, Berger PB, Kereiakes DJ, Serebruany VL, Brennan D, Topol EJ: Lack of adverse clopidogrel-atorvastatin clinical interaction from secondary analysis of a randomized, placebo-controlled clopidogrel trial. Circulation. 2003 Aug 26;108(8):921-4. Epub 2003 Aug 18. [PubMed:12925453]
  3. Neubauer H, Gunesdogan B, Hanefeld C, Spiecker M, Mugge A: Lipophilic statins interfere with the inhibitory effects of clopidogrel on platelet function--a flow cytometry study. Eur Heart J. 2003 Oct;24(19):1744-9. [PubMed:14522569]
  4. Lau WC, Gurbel PA, Watkins PB, Neer CJ, Hopp AS, Carville DG, Guyer KE, Tait AR, Bates ER: Contribution of hepatic cytochrome P450 3A4 metabolic activity to the phenomenon of clopidogrel resistance. Circulation. 2004 Jan 20;109(2):166-71. Epub 2004 Jan 5. [PubMed:14707025]
  5. Mukherjee D, Kline-Rogers E, Fang J, Munir K, Eagle KA: Lack of clopidogrel-CYP3A4 statin interaction in patients with acute coronary syndrome. Heart. 2005 Jan;91(1):23-6. [PubMed:15604326]
  6. Poulsen TS, Vinholt P, Mickley H, Korsholm L, Kristensen SR, Damkier P: Existence of a clinically relevant interaction between clopidogrel and HMG-CoA reductase inhibitors? Re-evaluating the evidence. Basic Clin Pharmacol Toxicol. 2005 Feb;96(2):103-10. [PubMed:15679472]
  7. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  8. Clarke TA, Waskell LA: The metabolism of clopidogrel is catalyzed by human cytochrome P450 3A and is inhibited by atorvastatin. Drug Metab Dispos. 2003 Jan;31(1):53-9. [PubMed:12485953]
Details
2. Cytochrome P450 2B6
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2B6
Uniprot ID
P20813
Uniprot Name
Cytochrome P450 2B6
Molecular Weight
56277.81 Da
References
  1. Walsky RL, Astuccio AV, Obach RS: Evaluation of 227 drugs for in vitro inhibition of cytochrome P450 2B6. J Clin Pharmacol. 2006 Dec;46(12):1426-38. [PubMed:17101742]
  2. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014]
  3. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP3A5
Uniprot ID
P20815
Uniprot Name
Cytochrome P450 3A5
Molecular Weight
57108.065 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Details
4. Cytochrome P450 2C19
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and im...
Gene Name
CYP2C19
Uniprot ID
P33261
Uniprot Name
Cytochrome P450 2C19
Molecular Weight
55930.545 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C9
Uniprot ID
P11712
Uniprot Name
Cytochrome P450 2C9
Molecular Weight
55627.365 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP1A2
Uniprot ID
P05177
Uniprot Name
Cytochrome P450 1A2
Molecular Weight
58293.76 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C8
Uniprot ID
P10632
Uniprot Name
Cytochrome P450 2C8
Molecular Weight
55824.275 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Triglyceride lipase activity
Specific Function
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acy...
Gene Name
CES1
Uniprot ID
P23141
Uniprot Name
Liver carboxylesterase 1
Molecular Weight
62520.62 Da
References
  1. Zhu HJ, Wang X, Gawronski BE, Brinda BJ, Angiolillo DJ, Markowitz JS: Carboxylesterase 1 as a determinant of clopidogrel metabolism and activation. J Pharmacol Exp Ther. 2013 Mar;344(3):665-72. doi: 10.1124/jpet.112.201640. Epub 2012 Dec 28. [PubMed:23275066]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Xenobiotic-transporting atpase activity
Specific Function
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name
ABCB1
Uniprot ID
P08183
Uniprot Name
Multidrug resistance protein 1
Molecular Weight
141477.255 Da
References
  1. Taubert D, von Beckerath N, Grimberg G, Lazar A, Jung N, Goeser T, Kastrati A, Schomig A, Schomig E: Impact of P-glycoprotein on clopidogrel absorption. Clin Pharmacol Ther. 2006 Nov;80(5):486-501. [PubMed:17112805]

Drug created on June 13, 2005 07:24 / Updated on November 13, 2017 21:49