Amino Acids, Cyclic

A class of amino acids characterized by a closed ring structure.
DrugDrug NameDrug Description
DB00117HistidineAn amino acid commonly found as a component of total parenteral nutrition.
DB00120PhenylalanineAn amino acid commonly found as a component of total parenteral nutrition.
DB00135TyrosineAn amino acid commonly found as a component in total parenteral nutrition.
DB00150TryptophanAn amino acid commonly found as a component of total parenteral nutrition.
DB00172ProlineAn amino acid commonly found as a component of total parenteral nutrition.
DB00451LevothyroxineA synthetic T4 hormone used to treat hypothyroidism that can be used along with surgery and radioiodine therapy to manage thyrotropin-dependent well-differentiated thyroid cancer.
DB00492FosinoprilAn ACE inhibitor used to treat mild to moderate hypertension, congestive heart failure, and to slow the progression of renal disease in hypertensive diabetics.
DB00509DextrothyroxineA thyroid hormone used to treat hyperlipidemia.
DB00731NateglinideA meglitinide used to treat non insulin dependent diabetes mellitus.
DB00765MetyrosineA tyrosine 3-monooxygenase inhibitor used to treat excessive sympathetic stimulation in pheochromocytoma.
DB00775TirofibanA platelet aggregation inhibitor used to prevent thrombotic events in non-ST elevated acute coronary syndrome.
DB00968MethyldopaAn alpha-2 adrenergic agonist used to treat hypertension.
DB01042MelphalanAn alkylating antineoplastic agent used to treat multiple myeloma and ovarian carcinoma.
DB01197CaptoprilAn ACE inhibitor used for the management of essential or renovascular hypertension, congestive heart failure, left ventricular dysfunction following myocardial infarction, and nephropathy.
DB01235LevodopaA dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism.
DB01583LiotrixMay be used to treat primary, secondary or tertiary hypothyroidism. May also be used to suppress thyroid stimulating hormone (TSH) secretion in patients with simple (nontoxic) goiter, subacute or chronic...
DB02543Pyrrole-2-CarboxylateNot Available
DB02810N-(2-Acetamido)Iminodiacetic AcidNot Available
DB02959OxitriptanFor use as an antidepressant, appetite suppressant, and sleep aid.
DB03088Pidolic acidThere is currently no clinically approved and/or marketed medicine that relies upon pidolic acid as an active ingredient for any formal therapeutic indication. Although pidolic acid may be sold in...
DB03157N,O-Didansyl-L-TyrosineNot Available
DB03223DiphthamideNot Available
DB03360N-AcetylprolineNot Available
DB03380L-tyrosinamideNot Available
DB035523-TyrosineNot Available
DB036604-Iodo-L-phenylalanineNot Available
DB03880BatimastatNot Available
DB04029Phenylalanine AmideNot Available
DB04284L-proline betaineNot Available
DB043346-hydroxydopa quinoneNot Available
DB04495RU81843Not Available
DB04584PhenyldehydroalanineNot Available
DB04620CycloleucineCycloleucine is non-metabolisable amino acid formed by cyclization of leucine. It is also a specific and reversible inhibitor of nucleic acid methylation and widely used in biochemical experiments.
DB05092CDP323Investigated for use/treatment in multiple sclerosis.
DB05199LX1031Irritable bowel syndrome (IBS) and other gastrointestinal disorders
DB05476WX-UK1Investigated for use/treatment in solid tumors.
DB06508GW-559090Investigated for use/treatment in asthma and allergic rhinitis.
DB06535EtilevodopaInvestigated for use/treatment in parkinson's disease.
DB08847HydroxyprolineUsed in France as a combination product for the treatment of small, superficial wounds.
DB08873BoceprevirA hepatitis C virus NS3/4A protease inhibitor used in combination with other medications to treat chronic hepatitis C genotype 1 infection. Boceprevir is not indicated as monotherapy.
DB09137Technetium Tc-99m mebrofeninA diagnostic radiopharmaceutical agent used during hepatobiliary imaging tests.
DB09164Technetium Tc-99m disofeninA radiopharmaceutical diagnostic agent used for hepatobiliary scans.
DB09230AzelnidipineFor the treatment of hypertension.
DB09272EluxadolineA mixed mu-opioid receptor agonist used to treat irritable bowel syndrome with diarrhea.
DB11091Hydrogen peroxideA compound used as a disinfectant and sterilizer.
DB11102N-acetyltyrosineAn amino acid used in total parenteral nutrition.
DB11364PidotimodFor use as immunostimulant therapy for treatment of cell-mediated immunosuppression with respiratory or urinary infections .
DB11611LifitegrastA medication used to treat dry eye disease.
DB11706RaxatrigineRaxatrigine has been investigated for the treatment of Bipolar Disorder and Bipolar Depression.
DB11821DanegaptideDanegaptide has been investigated for the treatment of Focus of Study is STEMI.
DB12095Telotristat ethylA tryptophan hydroxylase inhibitor used to treat carcinoid syndrome.
DB12224Oxothiazolidinecarboxylic acidProcysteine has been used in trials studying the treatment of HIV Infections.
DB126293,5-diiodothyropropionic acidDITPA has been investigated in Congestive Heart Failure.
DB12827IndoximodIndoximod has been used in trials studying the treatment of Glioma, Melanoma, Ependymoma, Gliosarcoma, and Lung Cancer, among others.
DB13074MacimorelinA medication used to treat adult growth hormone deficiency.
DB13091TiropramideTiropramide is under investigation in clinical trial NCT01629212 (Comparison of the Efficacy and Safety of Tiropramide and Octylonium in the Treatment of Irritable Bowel Syndrome).
DB13166ZofenoprilZofenopril is employed as both a cardioprotective and anti-hypertensive agent. It is an angiotensin-converting enzyme (ACE) inhibitor.
DB13313MelevodopaNot Annotated
DB13363OxaceprolNot Annotated
DB14028NordazepamAn intermediate in the metabolism of DIAZEPAM to OXAZEPAM. It may have actions similar to those of diazepam.
DB14207FosinoprilatFosinoprilat is the active phosphinic acid metabolite of prodrug fosinopril, which is activated by esterases in vivo. It binds zinc with phosphinic acid group.
DB14218TelotristatA tryptophan hydroxylase inhibitor. Telotristat ethyl (brand name Xermelo) is a prodrug of telotristat.
DB08766ZofenoprilatNot Available
DB06111AB192Investigated for use/treatment in diabetes mellitus type 2.
DB03604TiratricolA metabolite of T3 and T4 thyroid hormones; promoted for hyperlipidemia, localized lipodystrophy, and obesity. Tiratricol has been used in trials studying the treatment of Allan-Herndon-Dudley Syndrome.
DB033145-fluorotryptophan5-fluorotryptophan can be used as substrate analogue to study enzyme mechanisms by NMR spectroscopy.
DB15084GS-9191GS-9191 is under investigation in clinical trial NCT00499967 (Safety and Effectiveness Study of an Experimental Topical Ointment (GS-9191) for the Treatment of Genital Warts).
DB13848Fluorodopa (18F)Not Annotated
DB14754SolriamfetolSolriamfetol is indicated for treatment of daytime sleepiness associated with obstructive sleep apnea and narcolepsy, but is not a treatment for the underlying airway obstruction in apnea patients[FDA Label][A176534,A176744].
DrugDrug NameTargetType
DB00117HistidineHistidine decarboxylasetarget
DB00117HistidineHistidine--tRNA ligase, cytoplasmictarget
DB00117HistidineSodium-coupled neutral amino acid transporter 3target
DB00117HistidineHistidine ammonia-lyasetarget
DB00117HistidineMonocarboxylate transporter 10transporter
DB00120PhenylalanineTyrosine aminotransferasetarget
DB00120PhenylalanineLarge neutral amino acids transporter small subunit 2target
DB00120PhenylalaninePhenylalanine--tRNA ligase alpha subunittarget
DB00120PhenylalaninePhenylalanine-4-hydroxylasetarget
DB00120PhenylalaninePhenylalanine--tRNA ligase, mitochondrialtarget
DB00120PhenylalaninePhenylalanine--tRNA ligase beta subunittarget
DB00120PhenylalanineTyrosine 3-monooxygenasetarget
DB00120PhenylalanineMonocarboxylate transporter 10transporter
DB00135TyrosineTyrosine 3-monooxygenasetarget
DB00135TyrosineTyrosine--tRNA ligase, mitochondrialtarget
DB00135TyrosineTyrosine--tRNA ligase, cytoplasmictarget
DB00135TyrosineTyrosine aminotransferasetarget
DB00135TyrosineMonocarboxylate transporter 8transporter
DB00135TyrosineMonocarboxylate transporter 10transporter
DB00150TryptophanTryptophan--tRNA ligase, cytoplasmictarget
DB00150TryptophanTryptophan--tRNA ligasetarget
DB00150TryptophanTryptophan--tRNA ligase, mitochondrialtarget
DB00150TryptophanTryptophan 2,3-dioxygenaseenzyme
DB00150TryptophanAromatic-L-amino-acid decarboxylaseenzyme
DB00150TryptophanMonocarboxylate transporter 8transporter
DB00150TryptophanMonocarboxylate transporter 10transporter
DB00150TryptophanTryptophan--tRNA ligaseenzyme
DB00150TryptophanTryptophan--tRNA ligase, mitochondrialenzyme
DB00150TryptophanTryptophan 5-hydroxylase 1enzyme
DB00150TryptophanTryptophan 5-hydroxylase 2enzyme
DB00150TryptophanTryptophan--tRNA ligase, cytoplasmicenzyme
DB00150TryptophanIndoleamine 2,3-dioxygenase 1enzyme
DB00172ProlinePyrroline-5-carboxylate reductase 1, mitochondrialtarget
DB00172ProlineBifunctional glutamate/proline--tRNA ligasetarget
DB00172ProlineSodium- and chloride-dependent neutral and basic amino acid transporter B(0+)target
DB00172ProlineSodium-dependent proline transportertarget
DB00172ProlinePyrroline-5-carboxylate reductase 2target
DB00172ProlineProlyl 4-hydroxylase subunit alpha-2target
DB00172ProlineProline dehydrogenase 1, mitochondrialtarget
DB00172ProlinePeptidyl-prolyl cis-trans isomerase Htarget
DB00172ProlineProline synthase co-transcribed bacterial homolog proteintarget
DB00172ProlineProlyl 4-hydroxylase subunit alpha-1target
DB00172ProlinePeptidyl-prolyl cis-trans isomerase Btarget
DB00172ProlinePeptidyl-prolyl cis-trans isomerase F, mitochondrialtarget
DB00172ProlinePeptidyl-prolyl cis-trans isomerase Ctarget
DB00172ProlinePeptidyl-prolyl cis-trans isomerase Atarget
DB00172ProlinePeptidyl-prolyl cis-trans isomerase Gtarget
DB00172ProlineProlyl 3-hydroxylase 1target
DB00172ProlinePyrroline-5-carboxylate reductasetarget
DB00172ProlineProbable proline--tRNA ligase, mitochondrialtarget
DB00172ProlineProlyl 3-hydroxylase 2target
DB00172ProlineProlyl 3-hydroxylase 3target
DB00172ProlinePyrroline-5-carboxylate reductase 3target
DB00172ProlineTrans-L-3-hydroxyproline dehydratasetarget
DB00172ProlineProline dehydrogenase 1, mitochondrialenzyme
DB00172ProlineMonocarboxylate transporter 10transporter
DB00451LevothyroxineThyroid hormone receptor alphatarget
DB00451LevothyroxineThyroid hormone receptor betatarget
DB00451LevothyroxineCytochrome P450 2C8enzyme
DB00451LevothyroxineTransthyretincarrier
DB00451LevothyroxineSerum albumincarrier
DB00451LevothyroxineThyroxine-binding globulincarrier
DB00451LevothyroxineP-glycoprotein 1transporter
DB00451LevothyroxineMonocarboxylate transporter 8transporter
DB00451LevothyroxineSolute carrier organic anion transporter family member 1C1transporter
DB00451LevothyroxineSolute carrier organic anion transporter family member 1A2transporter
DB00451LevothyroxineSolute carrier organic anion transporter family member 1B1transporter
DB00451LevothyroxineSolute carrier organic anion transporter family member 1B3transporter
DB00451LevothyroxineSolute carrier organic anion transporter family member 4A1transporter
DB00451LevothyroxineSolute carrier organic anion transporter family member 4C1transporter
DB00451LevothyroxineLarge neutral amino acids transporter small subunit 1transporter
DB00451LevothyroxineUDP-glucuronosyltransferase 1-1enzyme
DB00451LevothyroxineSolute carrier organic anion transporter family member 2B1transporter
DB00451LevothyroxineIntegrin alpha-Vtarget
DB00451LevothyroxineIntegrin beta-3target
DB00451LevothyroxineP-glycoprotein 1enzyme
DB00492FosinoprilAngiotensin-converting enzymetarget
DB00492FosinoprilSolute carrier family 15 member 1transporter
DB00492FosinoprilSolute carrier family 15 member 2transporter
DB00509DextrothyroxineThyroid hormone receptor alphatarget
DB00509DextrothyroxineThyroid hormone receptor betatarget
DB00509DextrothyroxineThyroid peroxidasetarget
DB00509DextrothyroxineSolute carrier organic anion transporter family member 1B1transporter
DB00509DextrothyroxineSolute carrier organic anion transporter family member 1C1transporter
DB00509DextrothyroxineSolute carrier organic anion transporter family member 4A1transporter
DB00509DextrothyroxineSolute carrier organic anion transporter family member 4C1transporter
DB00509DextrothyroxineLarge neutral amino acids transporter small subunit 1transporter
DB00731NateglinideATP-binding cassette sub-family C member 8target
DB00731NateglinideCytochrome P450 3A4enzyme
DB00731NateglinideCytochrome P450 2C9enzyme
DB00731NateglinidePeroxisome proliferator-activated receptor gammatarget
DB00731NateglinideCytochrome P450 3A5enzyme
DB00731NateglinideCytochrome P450 3A7enzyme
DB00731NateglinideSolute carrier family 15 member 1transporter
DB00731NateglinideSolute carrier family 15 member 2transporter
DB00731NateglinideSolute carrier family 22 member 6transporter
DB00731NateglinideMonocarboxylate transporter 1transporter
DB00731NateglinideProstaglandin G/H synthase 1enzyme
DB00731NateglinideUDP-glucuronosyltransferase 1-9enzyme
DB00731NateglinideCytochrome P450 2D6enzyme
DB00731NateglinideMultidrug resistance-associated protein 4transporter
DB00731NateglinideSerum albumincarrier
DB00731NateglinideAlpha-1-acid glycoprotein 1carrier
DB00765MetyrosineTyrosine 3-monooxygenasetarget
DB00775TirofibanIntegrin alpha-IIbtarget
DB00775TirofibanIntegrin beta-3target
DB00968MethyldopaAlpha-2A adrenergic receptortarget
DB00968MethyldopaCatechol O-methyltransferaseenzyme
DB00968MethyldopaSolute carrier family 15 member 1transporter
DB00968MethyldopaAromatic-L-amino-acid decarboxylasetarget
DB01042MelphalanDNAtarget
DB01042MelphalanSolute carrier family 22 member 3transporter
DB01042MelphalanLarge neutral amino acids transporter small subunit 1transporter
DB01197CaptoprilAngiotensin-converting enzymetarget
DB01197CaptoprilSerum albumincarrier
DB01197Captopril72 kDa type IV collagenasetarget
DB01197CaptoprilMatrix metalloproteinase-9target
DB01197CaptoprilP-glycoprotein 1transporter
DB01197CaptoprilSolute carrier family 15 member 1transporter
DB01197CaptoprilSolute carrier family 22 member 6transporter
DB01197CaptoprilLeukotriene A-4 hydrolasetarget
DB01197CaptoprilB1 bradykinin receptortarget
DB01235LevodopaDopamine D1 receptortarget
DB01235LevodopaDopamine D2 receptortarget
DB01235LevodopaAromatic-L-amino-acid decarboxylaseenzyme
DB01235LevodopaSolute carrier family 15 member 1transporter
DB01235LevodopaMonocarboxylate transporter 10transporter
DB01235LevodopaDopamine D3 receptortarget
DB01235LevodopaDopamine D4 receptortarget
DB01235LevodopaDopamine D5 receptortarget
DB01235LevodopaLarge neutral amino acids transporter small subunit 1transporter
DB01235LevodopaLarge neutral amino acids transporter small subunit 2transporter
DB01235LevodopaSerum albumincarrier
DB01583LiotrixThyroid hormone receptor alphatarget
DB01583LiotrixThyroid hormone receptor betatarget
DB01583LiotrixCytochrome P450 2C8enzyme
DB01583LiotrixSolute carrier organic anion transporter family member 1A2transporter
DB01583LiotrixSolute carrier organic anion transporter family member 1B1transporter
DB01583LiotrixSolute carrier organic anion transporter family member 1B3transporter
DB01583LiotrixSolute carrier organic anion transporter family member 4C1transporter
DB01583LiotrixSodium/bile acid cotransportertransporter
DB01583LiotrixSolute carrier organic anion transporter family member 1C1transporter
DB01583LiotrixSolute carrier organic anion transporter family member 4A1transporter
DB01583LiotrixSolute carrier family 22 member 8transporter
DB01583LiotrixMonocarboxylate transporter 8transporter
DB01583LiotrixMonocarboxylate transporter 10transporter
DB01583LiotrixP-glycoprotein 1transporter
DB01583LiotrixTransthyretincarrier
DB01583LiotrixThyroxine-binding globulincarrier
DB01583LiotrixSerum albumincarrier
DB01583LiotrixCytochrome P450 3A4enzyme
DB02543Pyrrole-2-CarboxylateMonomeric sarcosine oxidasetarget
DB02810N-(2-Acetamido)Iminodiacetic AcidPeptide deformylasetarget
DB02959OxitriptanTryptophan--tRNA ligase 2target
DB03088Pidolic acidAlpha-amylase 2Btarget
DB03088Pidolic acidAngiogenintarget
DB03088Pidolic acidChondroitinase-Btarget
DB03088Pidolic acidAlpha-amylase 1target
DB03088Pidolic acidVascular endothelial growth factor Atarget
DB03088Pidolic acidPancreatic alpha-amylasetarget
DB03088Pidolic acidIg lambda-1 chain C regionstarget
DB03088Pidolic acidIg lambda chain V-II region MGCtarget
DB03088Pidolic acidTrefoil factor 2target
DB03088Pidolic acidCytochrome c2target
DB03088Pidolic acidDisintegrin and metalloproteinase domain-containing protein 28target
DB03088Pidolic acidEndo-1,4-beta-xylanasetarget
DB03088Pidolic acidDissimilatory copper-containing nitrite reductasetarget
DB03088Pidolic acidKeratin-associated protein 5-2target
DB03088Pidolic acidOrexintarget
DB03088Pidolic acidC-C motif chemokine 8target
DB03088Pidolic acidCytochrome c'target
DB03088Pidolic acidPancreatic alpha-amylaseenzyme
DB03157N,O-Didansyl-L-TyrosineThymidylate synthasetarget
DB03223DiphthamideElongation factor 2target
DB03360N-Acetylproline(5R)-carbapenem-3-carboxylate synthasetarget
DB03380L-tyrosinamidePro-neuropeptide Ytarget
DB03380L-tyrosinamideValacyclovir hydrolasetarget
DB035523-TyrosineTyrosine 3-monooxygenasetarget
DB036604-Iodo-L-phenylalanineLysozymetarget
DB036604-Iodo-L-phenylalaninePseudomonalisintarget
DB036604-Iodo-L-phenylalanineDipeptidyl peptidase 4target
DB036604-Iodo-L-phenylalanineAminopeptidase Starget
DB03880BatimastatNeutrophil collagenasetarget
DB03880BatimastatMacrophage metalloelastasetarget
DB03880BatimastatMatrix metalloproteinase-16target
DB03880BatimastatDisintegrin and metalloproteinase domain-containing protein 28target
DB03880BatimastatA disintegrin and metalloproteinase with thrombospondin motifs 5target
DB04029Phenylalanine AmideGenome polyproteintarget
DB04029Phenylalanine AmideGenome polyproteintarget
DB04029Phenylalanine AmideD-Amino acid amidasetarget
DB04284L-proline betaineGlycine betaine-binding periplasmic proteintarget
DB043346-hydroxydopa quinoneMembrane primary amine oxidasetarget
DB043346-hydroxydopa quinonePrimary amine oxidasetarget
DB043346-hydroxydopa quinonePhenylethylamine oxidasetarget
DB04495RU81843Proto-oncogene tyrosine-protein kinase Srctarget
DB04620CycloleucineGlutamate receptor ionotropic, NMDA 1target
DB05092CDP323Integrin alpha-4target
DB05199LX1031Tryptophan 5-hydroxylase 1target
DB05476WX-UK1Urokinase plasminogen activator surface receptortarget
DB08847HydroxyprolineProton-coupled amino acid transporter 1transporter
DB08873BoceprevirCytochrome P450 3A4enzyme
DB08873BoceprevirCytochrome P450 3A5enzyme
DB08873BoceprevirP-glycoprotein 1transporter
DB08873BoceprevirNS3/4A proteintarget
DB09137Technetium Tc-99m mebrofeninSolute carrier organic anion transporter family member 1B1transporter
DB09137Technetium Tc-99m mebrofeninSolute carrier organic anion transporter family member 1B3transporter
DB09230AzelnidipineCytochrome P450 3A4enzyme
DB09230AzelnidipineVoltage-dependent L-type calcium channel subunit beta-1target
DB09272EluxadolineMu-type opioid receptortarget
DB09272EluxadolineDelta-type opioid receptortarget
DB09272EluxadolineKappa-type opioid receptortarget
DB09272EluxadolineSolute carrier organic anion transporter family member 1B1transporter
DB09272EluxadolineCanalicular multispecific organic anion transporter 1transporter
DB09272EluxadolineSolute carrier family 22 member 8transporter
DB11091Hydrogen peroxideGlutathione peroxidase 1enzyme
DB11091Hydrogen peroxideCatalaseenzyme
DB11091Hydrogen peroxideAlkaline phosphatase, placental-likeenzyme
DB11611LifitegrastIntegrin alpha-Ltarget
DB11611LifitegrastCytochrome P450 2C9enzyme
DB11611LifitegrastSolute carrier organic anion transporter family member 1A2transporter
DB11611LifitegrastSolute carrier organic anion transporter family member 2B1transporter
DB12095Telotristat ethylTryptophan 5-hydroxylase 2target
DB12095Telotristat ethylTryptophan 5-hydroxylase 1target
DB126293,5-diiodothyropropionic acidCytochrome P450 3A4enzyme
DB13074MacimorelinGrowth hormone secretagogue receptor type 1target
DB13074MacimorelinCytochrome P450 3A4enzyme
DB13166ZofenoprilAngiotensin-converting enzymetarget
DB08766ZofenoprilatCytosol aminopeptidasetarget
DB06111AB192Myeloperoxidaseenzyme
DB03604TiratricolThyroid hormone receptor betatarget
DB033145-fluorotryptophanTriosephosphate isomerasetarget
DB033145-fluorotryptophanGlutathione S-transferase Mu 1target
DB14754SolriamfetolSolute carrier family 22 member 2transporter
DB14754SolriamfetolSolute carrier family 22 member 4transporter
DB14754SolriamfetolSolute carrier family 22 member 5transporter
DB14754SolriamfetolSodium-dependent dopamine transportertarget
DB14754SolriamfetolSodium-dependent noradrenaline transportertarget