Membrane Lipids

Lipids, predominantly phospholipids, cholesterol and small amounts of glycolipids found in membranes including cellular and intracellular membranes. These lipids may be arranged in bilayers in the membranes with integral proteins between the layers and peripheral proteins attached to the outside. Membrane lipids are required for active transport, several enzymatic activities and membrane formation.
DrugDrug NameDrug Indication
DB00136CalcitriolUsed to treat vitamin D deficiency or insufficiency, refractory rickets (vitamin D resistant rickets), familial hypophosphatemia and hypoparathyroidism, and in the management of hypocalcemia and renal osteodystrophy in patients with chronic renal failure undergoing dialysis. Also used in conjunction with calcium in the management and prevention of primary or corticosteroid-induced osteoporosis.
DB00146CalcidiolUsed to treat vitamin D deficiency or insufficiency, refractory rickets (vitamin D resistant rickets), familial hypophosphatemia and hypoparathyroidism, and in the management of hypocalcemia and renal osteodystrophy in patients with chronic renal failure undergoing dialysis. Also used in conjunction with calcium in the management and prevention of primary or corticosteroid-induced osteoporosis.
DB00153ErgocalciferolFor use in the management of hypocalcemia and its clinical manifestations in patients with hypoparathyroidism, as well as for the treatment of familial hypophosphatemia (vitamin D resistant rickets). This drug has also been used in the treatment of nutritional rickets or osteomalacia, vitamin D dependent rickets, rickets or osteomalacia secondary to long-term high dose anticonvulsant therapy, early renal osteodystrophy, osteoporosis (in conjunction with calcium), and hypophosphatemia associated with Fanconi syndrome (with treatment of acidosis).
DB00169CholecalciferolFor the treatment of vitamin D deficiency or insufficiency, refractory rickets (vitamin D resistant rickets), familial hypophosphatemia and hypoparathyroidism, and in the management of hypocalcemia and renal osteodystrophy in patients with chronic renal failure undergoing dialysis. Also used in conjunction with calcium in the management and prevention of primary or corticosteroid-induced osteoporosis.
DB00910ParicalcitolFor treatment of secondary hyperparathyroidism associated with chronic kidney disease (CKD) Stage 3 and 4
DB01070DihydrotachysterolUsed for the prevention and treatment of rickets or osteomalacia, and to manage hypocalcemia associated with hypoparathyroidism or pseudohypoparathyroidism. Also used for the treatment of vitamin D dependent rickets, rickets or osteomalacia secondary to long-term high dose anticonvulsant therapy, early renal osteodystrophy, osteoporosis (in conjunction with calcium), and hypophosphatemia associated with Fanconi syndrome (with treatment of acidosis).
DB01436AlfacalcidolAlfacalcidol is an active metabolite of Vitamin D, which performs important functions in regulation of the calcium balance and the bone metabolism.
DB02092Cholesteryl LinoleateNot Available
DB02261Platelet Activating FactorNot Available
DB02300CalcipotriolFor the treatment of moderate plaque psoriasis in adults.
DB02703Fusidic AcidFor the treatment of bacterial infections.
DB03429CardiolipinNot Available
DB03438LysophosphatidylglycerolNot Available
DB03696LanosterolNot Available
DB04038ErgosterolNot Available
DB04143Indole-3-Glycerol PhosphateNot Available
DB04258SeocalcitolNot Available
DB04327PhosphatidylethanolamineNot Available
DB04540CholesterolNot Available
DB04660Choline alfoscerateNot Available
DB0470420-hydroxycholesterolNot Available
DB04796InecalcitolInvestigated for use/treatment in prostate cancer, psoriasis and hyperparathyroidism.
DB04891BecocalcidiolFor topical treatment of psoriasis and psoriatic disorders.
DB04897LucinactantIntended for the prevention of respiratory distress syndrome (RDS) in premature infants at high risk for RDS.
DB04905TesmilifeneIntended for the treatment of various forms of cancer.
DB05295EldecalcitolInvestigated for use/treatment in osteoporosis.
DB05456ETC-588Investigated for use/treatment in atherosclerosis, coronary artery disease, and vascular diseases.
DB06194ElocalcitolInvestigated for use/treatment in benign prostatic hyperplasia, urinary incontinence, prostate disorders, and infertility.
DB06272MaxacalcitolNot Available
DB06410DoxercalciferolDoxercalciferol is indicated for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease on dialysis, as well as for the treatment of secondary hyperparathyroidism in patients with Stage 3 or Stage 4 chronic kidney disease.
DB09113Poractant alfaPoractant alfa is indicated for the treatment of Respiratory Distress Syndrome (RDS) in premature infants.
DB09114Colfosceril palmitateColfosceril palmitate is indicated for the treatment of respiratory distress syndrome (RDS) in premature infants. The official label is referred as a intratracheal suspension for prophylactic treatment of infants of less than 1350 grams of birth weight under risk of developing RDS, or in infants with birth weight greater than 1350 grams with pulmonary immaturity, or as rescue treatment of infants that already developed RDS.[L1109] The central feature of RDS is a surfactant deficiency due to lung immaturity. This lung condition is more frequently presented due to risk factors like prematurity, delayed lung maturation caused by maternal diabetes or male gender, or surfactant dysfuntion due to perinatal asphyxia, pulmonary infection or delivery without labor.[T70]
DB09561Sodium glycerophosphateSodium glycerophosphate is indicated for use as a source of phosphate in total parenteral nutrition [FDA Label]. It is used in combination with amino acids, dextrose, lipid emulsions, and other electrolytes.
DB11133Omega-3 fatty acidsProvided as daily supplements. Aa preparation of omega-3-acid ethyl esters is licensed in UK for prevention of recurrent events after myocardial infarction in addition to treatment of hypertriglyceridaemia.
DB11264Calcium glycerophosphateCalcium glycerophosphate is found in OTC dental products such as toothpastes for the prevention of dental caries. As OTC products these do not have an official indication. In prescription products it is indicated as a [DB01373] or phosphate donor for replacement or supplementation in patients with insufficient [DB01373] or phosphate.
DB11283DL-dimyristoylphosphatidylcholineDL-dimyristoylphosphatidylcholine is not an active pharmaceutical agent and has no indication.
DB11284DL-dimyristoylphosphatidylglycerolDL-dimyristoylphosphatidylglycerol is not an considered an active pharmacological ingredient in pharmaceutical preparations and so has no official indications.
DB12232KRN-7000Not Available
DB12351SiagosideNot Available
DB130971alpha-Hydroxyvitamin D5Not Available
DB13615MifamurtideIndicated in children, adolescents and young adults for the treatment of high-grade, resectable, non-metastatic osteosarcoma after macroscopically complete surgical resection, typically in combination with post-operative multi-agent chemotherapy [L1203].
DB13689TacalcitolNot Available
DB14038beta-SitosterolNot Available
DB140991,2-DistearoyllecithinNot Available
DB14111Ceramide NPNot Available
DB14705Ceramide APNot Available
DB14706Ceramide NGNot Available
DrugDrug NameTargetType
DB00136CalcitriolVitamin D3 receptortarget
DB00136Calcitriol1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
DB00136CalcitriolCytochrome P450 3A4enzyme
DB00136CalcitriolHomeobox protein Hox-A10target
DB00136CalcitriolVitamin D-binding proteintarget
DB00146Calcidiol25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialenzyme
DB00146CalcidiolVitamin D3 receptortarget
DB00146Calcidiol1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
DB00153ErgocalciferolVitamin D3 receptortarget
DB00153Ergocalciferol1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
DB00153Ergocalciferol25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialenzyme
DB00153ErgocalciferolSterol 26-hydroxylase, mitochondrialenzyme
DB00153ErgocalciferolCytochrome P450 3A4enzyme
DB00153ErgocalciferolVitamin D 25-hydroxylaseenzyme
DB00169CholecalciferolVitamin D-binding proteincarrier
DB00169CholecalciferolCholesterol side-chain cleavage enzyme, mitochondrialenzyme
DB00169CholecalciferolVitamin D 25-hydroxylaseenzyme
DB00169CholecalciferolSterol 26-hydroxylase, mitochondrialenzyme
DB00169CholecalciferolCytochrome P450 2J2enzyme
DB00169CholecalciferolCytochrome P450 3A4enzyme
DB00169CholecalciferolVitamin D3 receptortarget
DB00169CholecalciferolCytochrome P450 1A1enzyme
DB00169CholecalciferolCytochrome P450 2B6enzyme
DB00169CholecalciferolCytochrome P450 2C8enzyme
DB00169CholecalciferolCytochrome P450 2C9enzyme
DB00169CholecalciferolCytochrome P450 2D6enzyme
DB00910ParicalcitolVitamin D3 receptortarget
DB00910Paricalcitol1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
DB00910ParicalcitolCytochrome P450 3A4enzyme
DB00910ParicalcitolUDP-glucuronosyltransferase 1-4enzyme
DB01070DihydrotachysterolVitamin D3 receptortarget
DB01436AlfacalcidolVitamin D-binding proteincarrier
DB01436AlfacalcidolVitamin D3 receptortarget
DB01436Alfacalcidol25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialtarget
DB01436AlfacalcidolRetinoic acid receptor RXR-alphatarget
DB02092Cholesteryl LinoleateLipase 3target
DB02261Platelet Activating FactorGanglioside GM2 activatortarget
DB02261Platelet Activating FactorMultidrug resistance protein 1transporter
DB02261Platelet Activating FactorPlatelet-activating factor receptortarget
DB02300CalcipotriolVitamin D3 receptortarget
DB02300CalcipotriolMyeloperoxidaseenzyme
DB02300Calcipotriol1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
DB02703Fusidic AcidChloramphenicol acetyltransferase 3target
DB02703Fusidic AcidChloramphenicol acetyltransferasetarget
DB02703Fusidic AcidBile salt export pumptransporter
DB02703Fusidic AcidCanalicular multispecific organic anion transporter 1transporter
DB02703Fusidic AcidElongation factor Gtarget
DB02703Fusidic AcidCytochrome P450 2D6enzyme
DB02703Fusidic AcidCytochrome P450 3A4enzyme
DB02703Fusidic AcidUDP-glucuronosyltransferase 1-1enzyme
DB02703Fusidic AcidATP-binding cassette sub-family G member 2transporter
DB02703Fusidic AcidSolute carrier organic anion transporter family member 1B1transporter
DB03429CardiolipinADP/ATP translocase 1target
DB03696LanosterolLanosterol synthasetarget
DB04143Indole-3-Glycerol PhosphateTryptophan synthase alpha chaintarget
DB04143Indole-3-Glycerol PhosphateTryptophan synthase beta chaintarget
DB04258SeocalcitolVitamin D3 receptortarget
DB04327PhosphatidylethanolamineEndothelial protein C receptortarget
DB04327PhosphatidylethanolamineBacteriorhodopsintarget
DB04327PhosphatidylethanolaminePhosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENtarget
DB04540CholesterolNuclear receptor ROR-alphatarget
DB04540CholesterolMultidrug resistance protein 1transporter
DB04540CholesterolATP-binding cassette sub-family G member 2transporter
DB04540CholesterolNuclear receptor subfamily 1 group I member 3target
DB04540CholesterolVitamin D3 receptortarget
DB04540CholesterolC-type lectin domain family 4 member Etarget
DB04660Choline alfoscerateGanglioside GM2 activatortarget
DB04796InecalcitolVitamin D3 receptortarget
DB04891BecocalcidiolMediator of RNA polymerase II transcription subunit 1target
DB04891BecocalcidiolVitamin D3 receptortarget
DB04905TesmilifeneMultidrug resistance protein 1target
DB04905TesmilifeneHistamine H1 receptortarget
DB04905TesmilifeneCytochrome P450 3A4enzyme
DB04905TesmilifeneCytochrome P450 2D6enzyme
DB04905TesmilifeneCytochrome P450 1A1enzyme
DB05295EldecalcitolVitamin D3 receptortarget
DB06194ElocalcitolVitamin D3 receptortarget
DB06410DoxercalciferolSterol 26-hydroxylase, mitochondrialenzyme
DB06410DoxercalciferolVitamin D3 receptortarget
DB11133Omega-3 fatty acidsPeroxisome proliferator-activated receptor gammatarget
DB11133Omega-3 fatty acidsProstaglandin G/H synthase 2enzyme
DB11133Omega-3 fatty acidsArachidonate 5-lipoxygenaseenzyme
DB11133Omega-3 fatty acidsPeroxisome proliferator-activated receptor alphatarget
DB11133Omega-3 fatty acidsSterol regulatory element-binding protein 1target
DB13615MifamurtideToll-like receptor 4target
DB13615MifamurtideNucleotide-binding oligomerization domain-containing protein 2target