Membrane Lipids

Lipids, predominantly phospholipids, cholesterol and small amounts of glycolipids found in membranes including cellular and intracellular membranes. These lipids may be arranged in bilayers in the membranes with integral proteins between the layers and peripheral proteins attached to the outside. Membrane lipids are required for active transport, several enzymatic activities and membrane formation.
DrugDrug NameDrug Description
DB00136CalcitriolAn active metabolite of vitamin D that is used to treat hyperparathyroidism and is also used in dialysis patients to combat hypocalcemia.
DB00146CalcifediolAn active metabolite of vitamin D used to treat hyperparathyroidism as well as to combat hypocalcemia in dialysis patients.
DB00169CholecalciferolA form of Vitamin D used in the treatment of specific medical conditions such as refractory rickets, hypoparathyroidism, and familial hypophosphatemia, as well as osteoporosis and chronic kidney disease.
DB00910ParicalcitolA vitamin D analog used to treat hyperparathyroidism associated with stage 3 or greater chronic kidney disease.
DB01070DihydrotachysterolA synthetic analog of vitamin D that does not require renal activation like vitamin D2 or Vitamin D3.
DB01436AlfacalcidolA vitamin D analogue used for the management of hypocalcemia, secondary hyperparathyroidism, and osteodystrophy in patients with chronic renal failure.
DB02092Cholesteryl LinoleateNot Available
DB02261Platelet Activating FactorNot Available
DB02300CalcipotriolA topical synthetic vitamin D2 derivative used in the treatment of plaque psoriasis.
DB02703Fusidic acidA topical antibacterial agent used to prevent and treat mild to moderate skin infections caused by susceptible bacteria.
DB03438LysophosphatidylglycerolNot Available
DB03696LanosterolNot Available
DB04143Indole-3-Glycerol PhosphateNot Available
DB04258SeocalcitolNot Available
DB04327PhosphatidylethanolamineNot Available
DB04540CholesterolThe principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
DB04660Choline alfoscerateA component of phosphatidylcholines (lecithins), in which the two hydroxy groups of glycerol are esterified with fatty acids. (From Stedman, 26th ed) It counteracts the effects of urea on enzymes...
DB0470420-hydroxycholesterolNot Available
DB04796InecalcitolInvestigated for use/treatment in prostate cancer, psoriasis and hyperparathyroidism.
DB04891BecocalcidiolFor topical treatment of psoriasis and psoriatic disorders.
DB04897LucinactantIntended for the prevention of respiratory distress syndrome (RDS) in premature infants at high risk for RDS.
DB05456ETC-588Investigated for use/treatment in atherosclerosis, coronary artery disease, and vascular diseases.
DB06194ElocalcitolInvestigated for use/treatment in benign prostatic hyperplasia, urinary incontinence, prostate disorders, and infertility.
DB06272MaxacalcitolNot Annotated
DB06410DoxercalciferolA synthetic vitamin D2 analog used to treat secondary hyperparathyroidism in patients with chronic kidney disease with or without therapy of dialysis.
DB09113Poractant alfaA pulmonary surfactant used for the treatment of Respiratory Distress Syndrome (RDS) in premature infants.
DB09114Colfosceril palmitateA pulmonary surfactant used for the treatment of Respiratory Distress Syndrome (RDS) in premature infants.
DB09561Sodium glycerophosphateA medication used to treat hypophosphatemia.
DB11133Omega-3 fatty acidsAn ingredient found in a variety of supplements and vitamins.
DB11283DL-dimyristoylphosphatidylcholineDL-dimyristoylphosphatidylcholine is not an active pharmaceutical agent and has no indication.
DB11284DL-dimyristoylphosphatidylglycerolDL-dimyristoylphosphatidylglycerol is not an considered an active pharmacological ingredient in pharmaceutical preparations and so has no official indications.
DB12232KRN-7000KRN7000 has been used in trials studying the treatment of Lung Cancer, Chronic Hepatitis C, Hepatitis B, Chronic, Unspecified Adult Solid Tumor, Protocol Specific, and Prevention of GvHD in Patients...
DB12351SiagosideSiagoside has been investigated for the treatment of Parkinson Disease.
DB130971alpha-Hydroxyvitamin D51alpha-Hydroxyvitamin D5 (CARD-024) has been used in trials studying the treatment of Drug Safety and Heart; Disease, Activity.
DB13487Iodine (131I) norcholesterolNot Annotated
DB13615MifamurtideA muramyl dipeptide derivative used to treat high grade, resectable, non-metastatic osteosarcoma after surgical resection.
DB13689TacalcitolNot Annotated
DB14038beta-SitosterolActive fraction of Solanum trilobatum; reduces side-effects of radiation-induced toxicity.
DB140991,2-DistearoyllecithinNot Annotated
DB14111Ceramide NPCeramide NP is a lipid molecule included in a group of lipid molecules called ceramides. Ceramides are major lipid components in the stratum corneum of the human skin. Ceramide 3...
DB14705Ceramide APNot Annotated
DB14706Ceramide NGNot Annotated
DB01990Cholesterol sulfateComponent of human seminal plasma & spermatozoa.
DB11325Soy sterolNot Annotated
DB15259VB-201VB-201 is under investigation in clinical trial NCT01001468 (Study to Assess VB-201 in Patients With Psoriasis).
DB00144Phosphatidyl serineA nutrient used in some supplement products.
DB061171alpha,24S-Dihydroxyvitamin D2Investigated for use/treatment in parathyroid disorders.
DB04955PumactantInvestigated for use/treatment in asthma, lung injury, and surgical adhesions.
DB1555724-Homo-1,25-dihydroxyvitamin D324-Homo-1,25-dihydroxyvitamin D3 is a novel vitamin D analogue.
DrugDrug NameTargetType
DB00136CalcitriolVitamin D3 receptortarget
DB00136Calcitriol1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
DB00136CalcitriolCytochrome P450 3A4enzyme
DB00136CalcitriolHomeobox protein Hox-A10target
DB00136CalcitriolVitamin D-binding proteincarrier
DB00146Calcifediol25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialenzyme
DB00146CalcifediolVitamin D3 receptortarget
DB00146Calcifediol1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
DB00169CholecalciferolVitamin D-binding proteincarrier
DB00169CholecalciferolCholesterol side-chain cleavage enzyme, mitochondrialenzyme
DB00169CholecalciferolVitamin D 25-hydroxylaseenzyme
DB00169CholecalciferolSterol 26-hydroxylase, mitochondrialenzyme
DB00169CholecalciferolCytochrome P450 2J2enzyme
DB00169CholecalciferolCytochrome P450 3A4enzyme
DB00169CholecalciferolVitamin D3 receptortarget
DB00169CholecalciferolCytochrome P450 1A1enzyme
DB00169CholecalciferolCytochrome P450 2C8enzyme
DB00910ParicalcitolVitamin D3 receptortarget
DB00910Paricalcitol1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
DB00910ParicalcitolCytochrome P450 3A4enzyme
DB00910ParicalcitolUDP-glucuronosyltransferase 1-4enzyme
DB01070DihydrotachysterolVitamin D3 receptortarget
DB01436AlfacalcidolVitamin D-binding proteincarrier
DB01436AlfacalcidolVitamin D3 receptortarget
DB01436Alfacalcidol25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialtarget
DB01436AlfacalcidolRetinoic acid receptor RXR-alphatarget
DB02092Cholesteryl LinoleateLipase 3target
DB02261Platelet Activating FactorGanglioside GM2 activatortarget
DB02261Platelet Activating FactorP-glycoprotein 1transporter
DB02261Platelet Activating FactorPlatelet-activating factor receptortarget
DB02300CalcipotriolVitamin D3 receptortarget
DB02300Calcipotriol1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
DB02703Fusidic acidChloramphenicol acetyltransferase 3target
DB02703Fusidic acidChloramphenicol acetyltransferasetarget
DB02703Fusidic acidBile salt export pumptransporter
DB02703Fusidic acidCanalicular multispecific organic anion transporter 1transporter
DB02703Fusidic acidElongation factor Gtarget
DB02703Fusidic acidCytochrome P450 2D6enzyme
DB02703Fusidic acidCytochrome P450 3A4enzyme
DB02703Fusidic acidUDP-glucuronosyltransferase 1-1enzyme
DB02703Fusidic acidATP-binding cassette sub-family G member 2transporter
DB02703Fusidic acidSolute carrier organic anion transporter family member 1B1transporter
DB03696LanosterolLanosterol synthasetarget
DB04143Indole-3-Glycerol PhosphateTryptophan synthase alpha chaintarget
DB04143Indole-3-Glycerol PhosphateTryptophan synthase beta chaintarget
DB04258SeocalcitolVitamin D3 receptortarget
DB04327PhosphatidylethanolamineEndothelial protein C receptortarget
DB04327PhosphatidylethanolaminePhosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENtarget
DB04540CholesterolNuclear receptor ROR-alphatarget
DB04540CholesterolP-glycoprotein 1transporter
DB04540CholesterolATP-binding cassette sub-family G member 2transporter
DB04540CholesterolNuclear receptor subfamily 1 group I member 3target
DB04540CholesterolVitamin D3 receptortarget
DB04540CholesterolC-type lectin domain family 4 member Etarget
DB04660Choline alfoscerateGanglioside GM2 activatortarget
DB04796InecalcitolVitamin D3 receptortarget
DB04891BecocalcidiolMediator of RNA polymerase II transcription subunit 1target
DB04891BecocalcidiolVitamin D3 receptortarget
DB06194ElocalcitolVitamin D3 receptortarget
DB06410DoxercalciferolSterol 26-hydroxylase, mitochondrialenzyme
DB06410DoxercalciferolVitamin D3 receptortarget
DB11133Omega-3 fatty acidsPeroxisome proliferator-activated receptor gammatarget
DB11133Omega-3 fatty acidsProstaglandin G/H synthase 2enzyme
DB11133Omega-3 fatty acidsArachidonate 5-lipoxygenaseenzyme
DB11133Omega-3 fatty acidsPeroxisome proliferator-activated receptor alphatarget
DB11133Omega-3 fatty acidsSterol regulatory element-binding protein 1target
DB13615MifamurtideToll-like receptor 4target
DB13615MifamurtideNucleotide-binding oligomerization domain-containing protein 2target
DB01990Cholesterol sulfateNuclear receptor ROR-alphatarget
DB00144Phosphatidyl serinePhosphatidylserine decarboxylase proenzymetarget
DB00144Phosphatidyl serineScavenger receptor class B member 1target
DB00144Phosphatidyl serineProtein kinase C alpha typetarget
DB00144Phosphatidyl serinePhosphatidylserine synthase 1target
DB00144Phosphatidyl serineDiacylglycerol kinase gammatarget
DB00144Phosphatidyl serineDiacylglycerol kinase deltatarget
DB00144Phosphatidyl serinePhosphatidylserine synthase 2target
DB00144Phosphatidyl serineSphingomyelin phosphodiesterase 4target
DB00144Phosphatidyl serineSphingomyelin phosphodiesterase 3target
DB00144Phosphatidyl serineProbable phospholipid-transporting ATPase IAtarget