Membrane Lipids

Name
Membrane Lipids
Accession Number
DBCAT000313
Description

Lipids, predominantly phospholipids, cholesterol and small amounts of glycolipids found in membranes including cellular and intracellular membranes. These lipids may be arranged in bilayers in the membranes with integral proteins between the layers and peripheral proteins attached to the outside. Membrane lipids are required for active transport, several enzymatic activities and membrane formation.

Drugs
DrugDrug Description
CalcitriolAn active metabolite of vitamin D that is used to treat hyperparathyroidism and is also used in dialysis patients to combat hypocalcemia.
CalcifediolAn active metabolite of vitamin D used to treat hyperparathyroidism as well as to combat hypocalcemia in dialysis patients.
CholecalciferolA form of Vitamin D used in the treatment of specific medical conditions such as refractory rickets, hypoparathyroidism, and familial hypophosphatemia, as well as osteoporosis and chronic kidney disease.
ParicalcitolA vitamin D analog used to treat hyperparathyroidism associated with stage 3 or greater chronic kidney disease.
DihydrotachysterolA synthetic analog of vitamin D that does not require renal activation like vitamin D2 or Vitamin D3.
AlfacalcidolA vitamin D analogue used for the management of hypocalcemia, secondary hyperparathyroidism, and osteodystrophy in patients with chronic renal failure.
Cholesteryl LinoleateNot Available
Platelet Activating FactorNot Available
CalcipotriolA topical synthetic vitamin D2 derivative used in the treatment of plaque psoriasis.
Fusidic acidA topical antibacterial agent used to prevent and treat mild to moderate skin infections caused by susceptible bacteria.
LysophosphatidylglycerolNot Available
LanosterolNot Available
Indole-3-Glycerol PhosphateNot Available
SeocalcitolNot Available
PhosphatidylethanolamineNot Available
CholesterolThe principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
Choline alfoscerateA component of phosphatidylcholines (lecithins), in which the two hydroxy groups of glycerol are esterified with fatty acids. (From Stedman, 26th ed) It counteracts the effects of urea on enzymes...
20-hydroxycholesterolNot Available
InecalcitolInvestigated for use/treatment in prostate cancer, psoriasis and hyperparathyroidism.
BecocalcidiolFor topical treatment of psoriasis and psoriatic disorders.
LucinactantIntended for the prevention of respiratory distress syndrome (RDS) in premature infants at high risk for RDS.
ETC-588Investigated for use/treatment in atherosclerosis, coronary artery disease, and vascular diseases.
ElocalcitolInvestigated for use/treatment in benign prostatic hyperplasia, urinary incontinence, prostate disorders, and infertility.
MaxacalcitolNot Annotated
DoxercalciferolA synthetic vitamin D2 analog used to treat secondary hyperparathyroidism in patients with chronic kidney disease with or without therapy of dialysis.
Poractant alfaA pulmonary surfactant used for the treatment of Respiratory Distress Syndrome (RDS) in premature infants.
Colfosceril palmitateA pulmonary surfactant used for the treatment of Respiratory Distress Syndrome (RDS) in premature infants.
Sodium glycerophosphateA medication used to treat hypophosphatemia.
Omega-3 fatty acidsAn ingredient found in a variety of supplements and vitamins.
DL-dimyristoylphosphatidylcholineDL-dimyristoylphosphatidylcholine is not an active pharmaceutical agent and has no indication.
DL-dimyristoylphosphatidylglycerolDL-dimyristoylphosphatidylglycerol is not an considered an active pharmacological ingredient in pharmaceutical preparations and so has no official indications.
KRN-7000KRN7000 has been used in trials studying the treatment of Lung Cancer, Chronic Hepatitis C, Hepatitis B, Chronic, Unspecified Adult Solid Tumor, Protocol Specific, and Prevention of GvHD in Patients...
SiagosideSiagoside has been investigated for the treatment of Parkinson Disease.
1alpha-Hydroxyvitamin D51alpha-Hydroxyvitamin D5 (CARD-024) has been used in trials studying the treatment of Drug Safety and Heart; Disease, Activity.
Iodine (131I) norcholesterolNot Annotated
MifamurtideA muramyl dipeptide derivative used to treat high grade, resectable, non-metastatic osteosarcoma after surgical resection.
TacalcitolNot Annotated
beta-SitosterolActive fraction of Solanum trilobatum; reduces side-effects of radiation-induced toxicity.
1,2-DistearoyllecithinNot Annotated
Ceramide NPCeramide NP is a lipid molecule included in a group of lipid molecules called ceramides. Ceramides are major lipid components in the stratum corneum of the human skin. Ceramide 3...
Ceramide APNot Annotated
Ceramide NGNot Annotated
Cholesterol sulfateComponent of human seminal plasma & spermatozoa.
Soy sterolNot Annotated
VB-201VB-201 is under investigation in clinical trial NCT01001468 (Study to Assess VB-201 in Patients With Psoriasis).
Phosphatidyl serineA nutrient used in some supplement products.
1alpha,24S-Dihydroxyvitamin D2Investigated for use/treatment in parathyroid disorders.
PumactantInvestigated for use/treatment in asthma, lung injury, and surgical adhesions.
24-Homo-1,25-dihydroxyvitamin D324-Homo-1,25-dihydroxyvitamin D3 is a novel vitamin D analogue.
Previtamin D(3)Not Annotated
25-HydroxycholesterolNot Available
7beta-hydroxycholesterolNot Available
LexacalcitolLexacalcitol is a solid. This compound belongs to the vitamin D and derivatives class of chemicals. These are compounds containing a secosteroid backbone, usually secoergostane or secocholestane. It is known...
1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamineNot Available
Glycerol 2-phosphateNot Available
L-DilinoleoyllecithinNot Available
sn-glycero-3-phosphoethanolamineNot Available
CadaverineCadaverine is a foul-smelling diamine formed by bacterial decarboxylation of lysine.
Drugs & Drug Targets
DrugTargetType
CalcitriolVitamin D3 receptortarget
Calcitriol1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
CalcitriolCytochrome P450 3A4enzyme
CalcitriolHomeobox protein Hox-A10target
CalcitriolVitamin D-binding proteincarrier
Calcifediol25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialenzyme
CalcifediolVitamin D3 receptortarget
Calcifediol1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
CholecalciferolVitamin D-binding proteincarrier
CholecalciferolCholesterol side-chain cleavage enzyme, mitochondrialenzyme
CholecalciferolVitamin D 25-hydroxylaseenzyme
CholecalciferolSterol 26-hydroxylase, mitochondrialenzyme
CholecalciferolCytochrome P450 2J2enzyme
CholecalciferolCytochrome P450 3A4enzyme
CholecalciferolVitamin D3 receptortarget
CholecalciferolCytochrome P450 1A1enzyme
CholecalciferolCytochrome P450 2C8enzyme
ParicalcitolVitamin D3 receptortarget
Paricalcitol1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
ParicalcitolCytochrome P450 3A4enzyme
ParicalcitolUDP-glucuronosyltransferase 1-4enzyme
DihydrotachysterolVitamin D3 receptortarget
AlfacalcidolVitamin D-binding proteincarrier
AlfacalcidolVitamin D3 receptortarget
Alfacalcidol25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialtarget
AlfacalcidolRetinoic acid receptor RXR-alphatarget
Cholesteryl LinoleateLipase 3target
Platelet Activating FactorGanglioside GM2 activatortarget
Platelet Activating FactorP-glycoprotein 1transporter
Platelet Activating FactorPlatelet-activating factor receptortarget
CalcipotriolVitamin D3 receptortarget
CalcipotriolMyeloperoxidaseenzyme
Calcipotriol1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
Fusidic acidChloramphenicol acetyltransferase 3target
Fusidic acidChloramphenicol acetyltransferasetarget
Fusidic acidBile salt export pumptransporter
Fusidic acidCanalicular multispecific organic anion transporter 1transporter
Fusidic acidElongation factor Gtarget
Fusidic acidCytochrome P450 2D6enzyme
Fusidic acidCytochrome P450 3A4enzyme
Fusidic acidUDP-glucuronosyltransferase 1-1enzyme
Fusidic acidATP-binding cassette sub-family G member 2transporter
Fusidic acidSolute carrier organic anion transporter family member 1B1transporter
LanosterolLanosterol synthasetarget
Indole-3-Glycerol PhosphateTryptophan synthase alpha chaintarget
Indole-3-Glycerol PhosphateTryptophan synthase beta chaintarget
SeocalcitolVitamin D3 receptortarget
PhosphatidylethanolamineEndothelial protein C receptortarget
PhosphatidylethanolamineBacteriorhodopsintarget
PhosphatidylethanolaminePhosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENtarget
CholesterolNuclear receptor ROR-alphatarget
CholesterolP-glycoprotein 1transporter
CholesterolATP-binding cassette sub-family G member 2transporter
CholesterolNuclear receptor subfamily 1 group I member 3target
CholesterolVitamin D3 receptortarget
CholesterolC-type lectin domain family 4 member Etarget
Choline alfoscerateGanglioside GM2 activatortarget
InecalcitolVitamin D3 receptortarget
BecocalcidiolMediator of RNA polymerase II transcription subunit 1target
BecocalcidiolVitamin D3 receptortarget
ElocalcitolVitamin D3 receptortarget
DoxercalciferolSterol 26-hydroxylase, mitochondrialenzyme
DoxercalciferolVitamin D3 receptortarget
Omega-3 fatty acidsPeroxisome proliferator-activated receptor gammatarget
Omega-3 fatty acidsProstaglandin G/H synthase 2enzyme
Omega-3 fatty acidsArachidonate 5-lipoxygenaseenzyme
Omega-3 fatty acidsPeroxisome proliferator-activated receptor alphatarget
Omega-3 fatty acidsSterol regulatory element-binding protein 1target
MifamurtideToll-like receptor 4target
MifamurtideNucleotide-binding oligomerization domain-containing protein 2target
Cholesterol sulfateNuclear receptor ROR-alphatarget
Phosphatidyl serinePhosphatidylserine decarboxylase proenzymetarget
Phosphatidyl serineScavenger receptor class B member 1target
Phosphatidyl serineProtein kinase C alpha typetarget
Phosphatidyl serinePhosphatidylserine synthase 1target
Phosphatidyl serineDiacylglycerol kinase gammatarget
Phosphatidyl serineDiacylglycerol kinase deltatarget
Phosphatidyl serinePhosphatidylserine synthase 2target
Phosphatidyl serineSphingomyelin phosphodiesterase 4target
Phosphatidyl serineSphingomyelin phosphodiesterase 3target
Phosphatidyl serineProbable phospholipid-transporting ATPase IAtarget
LexacalcitolVitamin D3 receptortarget
1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamineRhodopsintarget
Glycerol 2-phosphateTriosephosphate isomerasetarget
L-DilinoleoyllecithinPhosphatidylcholine transfer proteintarget
sn-glycero-3-phosphoethanolamineAnnexin A5target
Cadaverine2-C-methyl-D-erythritol 4-phosphate cytidylyltransferasetarget