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Not Available
Identification
NameChloral hydrate
Accession NumberDB01563
TypeSmall Molecule
GroupsApproved, Illicit, Vet Approved
DescriptionA hypnotic and sedative used in the treatment of insomnia. The safety margin is too narrow for chloral hydrate to be used as a general anesthetic in humans, but it is commonly used for that purpose in animal experiments. It is no longer considered useful as an anti-anxiety medication. [PubChem]
Structure
Thumb
SynonymsNot Available
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Chloral Hydrate Capsules 500mgCapsule500 mgOralD.C. Labs Limited1968-12-312003-07-11Canada
Chloral Hydrate Syrup OdanSyrup100 mgOralOdan Laboratories Ltd2003-08-06Not applicableCanada
Novo-chlorhydrate Cap 500mgCapsule500 mgOralNovopharm Limited1967-12-312005-08-10Canada
PMS-chloral Hydrate Capsules 500mgCapsule500 mgOralPharmascience Inc1996-10-10Not applicableCanada
PMS-chloral Hydrate Syrup 100mg/mlSyrup100 mgOralPharmascience Inc1990-12-31Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-chloral Hydrate SyrupSyrup100 mgOralApotex IncNot applicableNot applicableCanada
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
Aquachloral SupprettesAmerifit Pharma
SomnoteBreckenridge
Brand mixtures
NameLabellerIngredients
Analgesic BalmD.C. Labs Limited
Calmitol Itching Relief OntPfizer Canada Inc., Consumer Healthcare Division
SaltsNot Available
Categories
UNII418M5916WG
CAS number302-17-0
WeightAverage: 165.403
Monoisotopic: 163.919862461
Chemical FormulaC2H3Cl3O2
InChI KeyRNFNDJAIBTYOQL-UHFFFAOYSA-N
InChI
InChI=1S/C2H3Cl3O2/c3-2(4,5)1(6)7/h1,6-7H
IUPAC Name
2,2,2-trichloroethane-1,1-diol
SMILES
OC(O)C(Cl)(Cl)Cl
Pharmacology
IndicationMainly used as a hyponotic in the treatment of insomnia; however, it is only effective as a hypnotic for short-term use. May be used as a routine sedative preoperatively to decrease anxiety and cause sedation and/or sleep with respiration depression or cough reflex.
Structured Indications
PharmacodynamicsNot Available
Mechanism of action
Related Articles
AbsorptionRapidly absorbed in the GI tract following oral or rectal administration. Chloral hydrate and its active metabolite, trichloroethanol, have been detected in CSF, umbilical cord blood, fetal blood, and amniotic fluid.
Volume of distributionNot Available
Protein bindingNot Available
Metabolism

Metabolized by the liver and erythrocytes to form trichloroethanol, an active metabolite. This reaction is catalyzed by alcohol dehydrogenase and other enzymes. Oxidation of chloral hydrate and trichloroethanol to trichloroacetic acid in the liver and kidneys also occurs to a lesser extent. Trichloroethanol also undergoes glucuronidation to produce an inactive metabolism.

Route of eliminationTrichloroethanol, trichloroethanol glucuronide, and trichloroacetic acid are excreted in the urine. Some trichloroethanol glucuronide may be secreted into bile and excreted in the feces.
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organismsNot Available
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
1,1,1,2 TetrafluoroethaneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with 1,1,1,2 Tetrafluoroethane.Investigational
7-NitroindazoleThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with 7-Nitroindazole.Experimental
AcenocoumarolThe serum concentration of Acenocoumarol can be increased when it is combined with Chloral hydrate.Approved
AcepromazineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Acepromazine.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Aceprometazine.Approved
adipiplonThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with adipiplon.Investigational
AgomelatineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Agomelatine.Approved, Investigational
AlfaxaloneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Alfaxalone.Vet Approved
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Chloral hydrate.Approved, Illicit
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Chloral hydrate.Experimental, Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Chloral hydrate.Approved, Illicit, Investigational
AmisulprideThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Amisulpride.Approved, Investigational
AmitriptylineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Amitriptyline.Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Chloral hydrate.Approved, Illicit
AmoxapineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Amoxapine.Approved
AmperozideThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Amperozide.Experimental
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Chloral hydrate.Approved, Investigational
ArticaineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Articaine.Approved
AsenapineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Asenapine.Approved
AzaperoneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Azaperone.Vet Approved
AzelastineChloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
AzelastineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Azelastine.Approved
BaclofenThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Baclofen.Approved
BarbitalThe risk or severity of adverse effects can be increased when Barbital is combined with Chloral hydrate.Illicit
BenperidolThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Benperidol.Investigational
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Chloral hydrate.Approved
Benzyl alcoholThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Benzyl alcohol.Approved
BrexpiprazoleThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Brexpiprazole.Approved
BrimonidineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Brimonidine.Approved
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.Approved
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Chloral hydrate.Approved, Illicit
BrompheniramineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Brompheniramine.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Brotizolam.Approved, Withdrawn
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Chloral hydrate.Approved, Investigational
BuprenorphineChloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Chloral hydrate.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Chloral hydrate.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Butacaine.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Butalbital.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Butamben.Approved
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Chloral hydrate.Approved, Illicit
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Chloral hydrate.Approved, Illicit, Vet Approved
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Chloral hydrate.Approved, Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Carbinoxamine.Approved
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Chloral hydrate.Illicit, Vet Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Carisoprodol.Approved
CetirizineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Cetirizine.Approved
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Chloral hydrate.Approved, Illicit
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Chloral hydrate.Approved, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Chloral hydrate.Approved
ChlorphenamineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Chlorphenamine.Approved
ChlorpromazineThe risk or severity of adverse effects can be increased when Chlorpromazine is combined with Chloral hydrate.Approved, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Chloral hydrate.Approved, Withdrawn
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Chlorzoxazone.Approved
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Chloral hydrate.Approved, Vet Approved
CitalopramThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Citalopram.Approved
ClemastineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Clemastine.Approved
ClidiniumThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Clidinium.Approved
ClobazamThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Clobazam.Approved, Illicit
clomethiazoleThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with clomethiazole.Investigational
ClomipramineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Clomipramine.Approved, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Clonazepam.Approved, Illicit
ClonidineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Clonidine.Approved
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Chloral hydrate.Approved, Illicit
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Chloral hydrate.Approved
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Chloral hydrate.Approved, Illicit
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Chloral hydrate.Approved, Illicit
CyclizineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Cyclizine.Approved
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Chloral hydrate.Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Cyproheptadine.Approved
DantroleneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Dantrolene.Approved
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Chloral hydrate.Approved
DapoxetineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Dapoxetine.Investigational
deramciclaneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with deramciclane.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Chloral hydrate.Approved
DesipramineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Desipramine.Approved
DesloratadineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Desloratadine.Approved, Investigational
DesvenlafaxineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Desvenlafaxine.Approved
DetomidineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Detomidine.Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Dexbrompheniramine.Approved
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Chloral hydrate.Approved, Vet Approved
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Chloral hydrate.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Chloral hydrate.Approved, Illicit, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Chloral hydrate.Approved
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Chloral hydrate.Approved, Illicit, Vet Approved
DicoumarolThe serum concentration of Dicoumarol can be increased when it is combined with Chloral hydrate.Approved
DifenoxinThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Difenoxin.Approved, Illicit
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Chloral hydrate.Approved, Illicit
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Chloral hydrate.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Dihydromorphine.Experimental, Illicit
DimenhydrinateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Dimenhydrinate.Approved
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Chloral hydrate.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Chloral hydrate.Approved, Illicit
DoramectinThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Doramectin.Vet Approved
DoxepinThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Doxepin.Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with DPDPE.Investigational
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.Approved, Illicit
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.Approved, Vet Approved
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Chloral hydrate.Experimental, Illicit
DuloxetineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Duloxetine.Approved
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Chloral hydrate.Approved
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Chloral hydrate.Experimental, Illicit
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with ECGONINE METHYL ESTER.Experimental
EcopipamThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Ecopipam.Investigational
EfavirenzThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Efavirenz.Approved, Investigational
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Chloral hydrate.Approved, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Entacapone.Approved, Investigational
EscitalopramThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Escitalopram.Approved, Investigational
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Chloral hydrate.Approved, Illicit
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Chloral hydrate.Approved
EthanolChloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Chloral hydrate.Approved, Illicit, Withdrawn
EthosuximideThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Ethosuximide.Approved
EthotoinThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Ethotoin.Approved
Ethyl biscoumacetateThe serum concentration of Ethyl biscoumacetate can be increased when it is combined with Chloral hydrate.Withdrawn
Ethyl carbamateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Ethyl carbamate.Withdrawn
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Chloral hydrate.Approved, Illicit
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Chloral hydrate.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Etidocaine.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Etifoxine.Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Etizolam.Approved
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Chloral hydrate.Approved
EtoperidoneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Etoperidone.Approved
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Chloral hydrate.Illicit, Vet Approved
EzogabineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Ezogabine.Approved
FelbamateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Felbamate.Approved
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Chloral hydrate.Approved, Illicit, Withdrawn
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Chloral hydrate.Approved, Illicit, Investigational, Vet Approved
FexofenadineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Fexofenadine.Approved
FlibanserinThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Flibanserin.Approved
FludiazepamThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Fludiazepam.Approved, Illicit
FluindioneThe serum concentration of Fluindione can be increased when it is combined with Chloral hydrate.Investigational
FlunarizineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Flunarizine.Approved
FlunitrazepamThe risk or severity of adverse effects can be increased when Flunitrazepam is combined with Chloral hydrate.Approved, Illicit
FluoxetineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Chloral hydrate.Approved, Withdrawn
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Chloral hydrate.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Chloral hydrate.Approved, Illicit
FluspirileneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Fluspirilene.Approved
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Fluticasone Propionate.Approved
FluvoxamineThe risk or severity of adverse effects can be increased when Fluvoxamine is combined with Chloral hydrate.Approved, Investigational
FosphenytoinThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Fosphenytoin.Approved
FospropofolThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Fospropofol.Approved, Illicit
FurosemideThe risk or severity of adverse effects can be increased when Furosemide is combined with Chloral hydrate.Approved, Vet Approved
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Chloral hydrate.Approved, Investigational
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with gabapentin enacarbil.Approved
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Chloral hydrate.Approved, Illicit
GepironeThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Gepirone.Investigational
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Chloral hydrate.Approved, Illicit
GuanfacineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Guanfacine.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Chloral hydrate.Approved, Illicit, Withdrawn
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with Chloral hydrate.Approved
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Chloral hydrate.Approved, Vet Approved
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Chloral hydrate.Approved, Illicit
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Chloral hydrate.Approved
HydrocodoneChloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Chloral hydrate.Approved, Illicit
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.Approved
IloperidoneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Iloperidone.Approved
ImipramineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Imipramine.Approved
IndalpineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Indalpine.Investigational, Withdrawn
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Chloral hydrate.Approved, Vet Approved
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Chloral hydrate.Approved, Vet Approved
KetazolamThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Ketazolam.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Ketobemidone.Approved
LamotrigineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Lamotrigine.Approved, Investigational
LevetiracetamThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Levetiracetam.Approved, Investigational
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Chloral hydrate.Approved
LevocabastineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Levocabastine.Approved
LevocetirizineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Levocetirizine.Approved
LevodopaThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Levodopa.Approved
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Chloral hydrate.Approved
LevomilnacipranThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Levomilnacipran.Approved
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Chloral hydrate.Approved
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Chloral hydrate.Approved, Vet Approved
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with Chloral hydrate.Approved
LofentanilThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Lofentanil.Illicit
LoratadineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Loratadine.Approved
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Chloral hydrate.Approved
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Chloral hydrate.Approved
Lu AA21004The risk or severity of adverse effects can be increased when Chloral hydrate is combined with Lu AA21004.Investigational
LurasidoneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Lurasidone.Approved
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.Approved, Vet Approved
MaprotilineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Maprotiline.Approved
MeclizineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Meclizine.Approved
MedetomidineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Medetomidine.Vet Approved
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Chloral hydrate.Approved, Nutraceutical, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Melperone.Approved
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Chloral hydrate.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Chloral hydrate.Approved, Illicit
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Chloral hydrate.Approved
MetaxaloneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Metaxalone.Approved
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Chloral hydrate.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Chloral hydrate.Approved, Illicit
MethapyrileneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Methapyrilene.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Methaqualone.Illicit, Withdrawn
MethocarbamolThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Methocarbamol.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Chloral hydrate.Approved
MethotrimeprazineChloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Chloral hydrate.Approved, Vet Approved
MethsuximideThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Methsuximide.Approved
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Chloral hydrate.Approved
MetyrosineChloral hydrate may increase the sedative activities of Metyrosine.Approved
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Chloral hydrate.Approved, Illicit
MilnacipranThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Milnacipran.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.Approved, Investigational
MirtazapineChloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MolindoneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Molindone.Approved
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Chloral hydrate.Approved, Investigational
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.Approved, Investigational
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Chloral hydrate.Approved
NefazodoneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Nefazodone.Approved, Withdrawn
NitrazepamThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Nitrazepam.Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Nitrous oxide.Approved, Vet Approved
NormethadoneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Normethadone.Approved, Illicit
NortriptylineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Nortriptyline.Approved
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Chloral hydrate.Approved, Investigational
OlopatadineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Olopatadine.Approved
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Chloral hydrate.Approved
OpiumThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Opium.Approved, Illicit
OrphenadrineChloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Osanetant.Investigational
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Chloral hydrate.Approved
OxetacaineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Oxetacaine.Investigational
OxprenololThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Oxprenolol.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Chloral hydrate.Approved
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Chloral hydrate.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Chloral hydrate.Approved, Investigational, Vet Approved
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Chloral hydrate.Approved
ParaldehydeChloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ParoxetineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Paroxetine.Approved, Investigational
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Chloral hydrate.Approved, Vet Approved
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Chloral hydrate.Approved, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.Approved
PerazineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Perazine.Investigational
PerospironeThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Perospirone.Approved
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Chloral hydrate.Approved
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Chloral hydrate.Approved
PhenindioneThe serum concentration of Phenindione can be increased when it is combined with Chloral hydrate.Approved
PhenobarbitalThe risk or severity of adverse effects can be increased when Phenobarbital is combined with Chloral hydrate.Approved
PhenoxyethanolThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Phenoxyethanol.Approved
PhenprocoumonThe serum concentration of Phenprocoumon can be increased when it is combined with Chloral hydrate.Approved
PhenytoinThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Phenytoin.Approved, Vet Approved
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Chloral hydrate.Approved
PipamperoneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Pipamperone.Approved
PipotiazineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Pipotiazine.Approved
PiritramideThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Piritramide.Investigational
PizotifenThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Pizotifen.Approved
PomalidomideThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Pomalidomide.Approved
PramipexoleChloral hydrate may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Pramocaine.Approved
PrazepamThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Prazepam.Approved, Illicit
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Chloral hydrate.Approved, Illicit, Investigational
PregnanoloneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Pregnanolone.Investigational
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Chloral hydrate.Approved
PrimidoneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Primidone.Approved, Vet Approved
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Chloral hydrate.Approved, Investigational, Vet Approved
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Chloral hydrate.Approved, Vet Approved
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Chloral hydrate.Approved, Vet Approved
PromethazineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Promethazine.Approved
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Chloral hydrate.Approved, Vet Approved
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Chloral hydrate.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Propoxycaine.Approved
ProtriptylineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Protriptyline.Approved
PSD502The risk or severity of adverse effects can be increased when Chloral hydrate is combined with PSD502.Investigational
QuazepamThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Quazepam.Approved, Illicit
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Chloral hydrate.Approved
RacloprideThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Raclopride.Investigational
RamelteonThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Ramelteon.Approved, Investigational
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Chloral hydrate.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Chloral hydrate.Approved, Withdrawn
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Chloral hydrate.Approved
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Chloral hydrate.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Ritanserin.Investigational
RomifidineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Romifidine.Vet Approved
RopiniroleChloral hydrate may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Chloral hydrate.Approved
RotigotineChloral hydrate may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Chloral hydrate.Approved
S-EthylisothioureaThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with S-Ethylisothiourea.Experimental
Sage 547The risk or severity of adverse effects can be increased when Chloral hydrate is combined with Sage 547.Investigational
ScopolamineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Scopolamine.Approved
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Chloral hydrate.Approved, Vet Approved
SertindoleThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Sertindole.Approved, Withdrawn
SertralineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Chloral hydrate.Approved, Vet Approved
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.Approved
StiripentolThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Stiripentol.Approved
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Chloral hydrate.Approved, Investigational
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Chloral hydrate.Approved
SuvorexantChloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
TandospironeThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Tasimelteon.Approved
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Chloral hydrate.Approved
TetrabenazineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Tetrabenazine.Approved
TetracaineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Tetracaine.Approved, Vet Approved
TetrodotoxinThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Tetrodotoxin.Investigational
ThalidomideChloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Chloral hydrate.Approved, Vet Approved
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Chloral hydrate.Approved, Vet Approved
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Chloral hydrate.Approved
ThiothixeneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Thiothixene.Approved
TiagabineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Tiagabine.Approved
TiaprideThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Tiapride.Investigational
TiletamineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Tiletamine.Vet Approved
TizanidineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Tizanidine.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Tolcapone.Approved, Withdrawn
TopiramateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Topiramate.Approved
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Chloral hydrate.Approved, Investigational
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Trans-2-Phenylcyclopropylamine.Experimental
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Chloral hydrate.Approved
TrazodoneThe risk or severity of adverse effects can be increased when Trazodone is combined with Chloral hydrate.Approved, Investigational
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Chloral hydrate.Approved
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Chloral hydrate.Approved
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Chloral hydrate.Approved, Vet Approved
TrimipramineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Trimipramine.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Triprolidine.Approved
Uc1010The risk or severity of adverse effects can be increased when Chloral hydrate is combined with Uc1010.Investigational
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Chloral hydrate.Approved, Investigational
VenlafaxineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Venlafaxine.Approved
VigabatrinThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Vigabatrin.Approved
VortioxetineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Vortioxetine.Approved
WarfarinThe serum concentration of Warfarin can be increased when it is combined with Chloral hydrate.Approved
XylazineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Xylazine.Vet Approved
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Chloral hydrate.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Ziconotide.Approved
ZimelidineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Zimelidine.Withdrawn
ZiprasidoneThe risk or severity of adverse effects can be increased when Ziprasidone is combined with Chloral hydrate.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Zolazepam.Vet Approved
ZolpidemChloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Zonisamide.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Chloral hydrate.Approved
ZotepineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Zotepine.Approved
ZuclopenthixolThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Zuclopenthixol.Approved, Investigational
Food InteractionsNot Available
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External Links
ATC CodesN05CC01
AHFS Codes
  • 28:24.92
PDB EntriesNot Available
FDA labelNot Available
MSDSNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9591
Blood Brain Barrier+0.9555
Caco-2 permeable-0.5795
P-glycoprotein substrateNon-substrate0.8757
P-glycoprotein inhibitor INon-inhibitor0.9923
P-glycoprotein inhibitor IINon-inhibitor0.9794
Renal organic cation transporterNon-inhibitor0.9454
CYP450 2C9 substrateNon-substrate0.7898
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateNon-substrate0.7558
CYP450 1A2 substrateNon-inhibitor0.7969
CYP450 2C9 inhibitorNon-inhibitor0.8017
CYP450 2D6 inhibitorNon-inhibitor0.9417
CYP450 2C19 inhibitorNon-inhibitor0.847
CYP450 3A4 inhibitorNon-inhibitor0.9446
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9778
Ames testAMES toxic0.6454
CarcinogenicityCarcinogens 0.616
BiodegradationNot ready biodegradable0.8453
Rat acute toxicity2.5068 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9837
hERG inhibition (predictor II)Non-inhibitor0.9558
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
OintmentTopical
CapsuleOral500 mg
SyrupOral100 mg
Prices
Unit descriptionCostUnit
Pms-Chloral Hydrate 100 mg/ml Syrup0.05USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point57 °CPhysProp
boiling point98 °CPhysProp
water solubility7.93E+005 mg/L (at 25 °C)YALKOWSKY,SH & HE,Y (2003)
logP0.99HANSCH,C ET AL. (1995)
Predicted Properties
PropertyValueSource
Water Solubility43.4 mg/mLALOGPS
logP0.88ALOGPS
logP0.69ChemAxon
logS-0.58ALOGPS
pKa (Strongest Acidic)9.51ChemAxon
pKa (Strongest Basic)-5.1ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area40.46 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity29.25 m3·mol-1ChemAxon
Polarizability11.88 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (8.88 KB)
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as chlorohydrins. These are alcohols substituted by a chlorine atom at a saturated carbon atom otherwise bearing only hydrogen or hydrocarbyl groups.
KingdomOrganic compounds
Super ClassOrganohalogen compounds
ClassHalohydrins
Sub ClassChlorohydrins
Direct ParentChlorohydrins
Alternative Parents
Substituents
  • Chlorohydrin
  • 1,1-diol
  • Carbonyl hydrate
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organochloride
  • Alkyl halide
  • Alkyl chloride
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Comments
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Drug created on July 31, 2007 07:10 / Updated on August 17, 2016 12:23