Chloral hydrate

Identification

Name
Chloral hydrate
Accession Number
DB01563
Type
Small Molecule
Groups
Approved, Illicit, Investigational, Vet approved
Description

A hypnotic and sedative used in the treatment of insomnia. The safety margin is too narrow for chloral hydrate to be used as a general anesthetic in humans, but it is commonly used for that purpose in animal experiments. It is no longer considered useful as an anti-anxiety medication.

Structure
Thumb
Synonyms
  • 1,1,1-trichloro-2,2-dihydroxyethane
  • 1,1,1-trichloro-2,2-ethanediol
  • 2,2,2-trichloro-1,1-ethanediol
  • chloral monohydrate
  • Chloralhydrat
  • Trichloracetaldehyd-hydrat
  • trichloroacetaldehyde hydrate
External IDs
NSC-3210
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Chloral Hydrate Capsules 500mgCapsule500 mgOralD.C. Labs Limited1968-12-312003-07-11Canada
Chloral Hydrate Syrup OdanSyrup500 mgOralOdan Laboratories Ltd2003-08-06Not applicableCanada
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-chloral Hydrate SyrupSyrup100 mgOralApotex CorporationNot applicableNot applicableCanada
Novo-chlorhydrate Cap 500mgCapsule500 mgOralNovopharm Limited1967-12-312005-08-10Canada
PMS-chloral Hydrate Capsules 500mgCapsule500 mgOralPharmascience Inc1996-10-10Not applicableCanada
PMS-chloral Hydrate Syrup 100mg/mlSyrup500 mgOralPharmascience Inc1990-12-31Not applicableCanada
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Analgesic BalmChloral hydrate (1 g) + Menthol (10 g) + Methyl salicylate (15 g)OintmentTopicalD.C. Labs Limited1966-12-312003-07-11Canada
Calmitol Itching Relief OntChloral hydrate (.496 %) + Camphor (.62 %) + Hyoscyamine (.0001 %) + Menthol (.58 %) + Zinc oxide (12.5 %)OintmentTopicalPfizer Canada Inc., Consumer Healthcare Division1964-12-311996-09-09Canada
International/Other Brands
Aquachloral Supprettes (Amerifit Pharma) / Somnote (Breckenridge)
Categories
UNII
418M5916WG
CAS number
302-17-0
Weight
Average: 165.403
Monoisotopic: 163.919862461
Chemical Formula
C2H3Cl3O2
InChI Key
RNFNDJAIBTYOQL-UHFFFAOYSA-N
InChI
InChI=1S/C2H3Cl3O2/c3-2(4,5)1(6)7/h1,6-7H
IUPAC Name
2,2,2-trichloroethane-1,1-diol
SMILES
OC(O)C(Cl)(Cl)Cl

Pharmacology

Indication

Mainly used as a hyponotic in the treatment of insomnia; however, it is only effective as a hypnotic for short-term use. May be used as a routine sedative preoperatively to decrease anxiety and cause sedation and/or sleep with respiration depression or cough reflex.

Associated Conditions
Associated Therapies
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption

Rapidly absorbed in the GI tract following oral or rectal administration. Chloral hydrate and its active metabolite, trichloroethanol, have been detected in CSF, umbilical cord blood, fetal blood, and amniotic fluid.

Volume of distribution
Not Available
Protein binding
Not Available
Metabolism

Metabolized by the liver and erythrocytes to form trichloroethanol, an active metabolite. This reaction is catalyzed by alcohol dehydrogenase and other enzymes. Oxidation of chloral hydrate and trichloroethanol to trichloroacetic acid in the liver and kidneys also occurs to a lesser extent. Trichloroethanol also undergoes glucuronidation to produce an inactive metabolism.

Route of elimination

Trichloroethanol, trichloroethanol glucuronide, and trichloroacetic acid are excreted in the urine. Some trichloroethanol glucuronide may be secreted into bile and excreted in the feces.

Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
7-NitroindazoleThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with 7-Nitroindazole.Experimental
AcenocoumarolThe serum concentration of Acenocoumarol can be increased when it is combined with Chloral hydrate.Approved, Investigational
AcepromazineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Acepromazine.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Aceprometazine.Approved
AdipiplonThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Adipiplon.Investigational
AgomelatineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Agomelatine.Approved, Investigational
AlaproclateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Alaproclate.Experimental
AlfaxaloneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Alfaxalone.Vet Approved
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Chloral hydrate.Approved, Illicit
AllopregnanoloneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Allopregnanolone.Investigational
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Chloral hydrate.Experimental, Illicit
AlphaprodineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Alphaprodine.Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Chloral hydrate.Approved, Illicit, Investigational
AmisulprideThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Amisulpride.Approved, Investigational
AmitriptylineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Chloral hydrate.Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Chloral hydrate.Approved, Illicit
AmoxapineThe risk or severity of adverse effects can be increased when Amoxapine is combined with Chloral hydrate.Approved
AmperozideThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Amperozide.Experimental
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Chloral hydrate.Approved, Investigational
ArticaineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Articaine.Approved
AsenapineThe risk or severity of adverse effects can be increased when Asenapine is combined with Chloral hydrate.Approved
AzaperoneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Azaperone.Investigational, Vet Approved
AzelastineChloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Chloral hydrate.Approved
BarbitalThe risk or severity of adverse effects can be increased when Barbital is combined with Chloral hydrate.Illicit
BenperidolThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Benperidol.Approved, Investigational
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Chloral hydrate.Approved, Investigational
Benzyl alcoholThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Benzyl alcohol.Approved
BrexpiprazoleThe risk or severity of adverse effects can be increased when Brexpiprazole is combined with Chloral hydrate.Approved, Investigational
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.Approved
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Chloral hydrate.Approved, Illicit, Investigational
BromisovalThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Bromisoval.Experimental
BromperidolThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Bromperidol.Approved, Investigational
BrompheniramineThe risk or severity of adverse effects can be increased when Brompheniramine is combined with Chloral hydrate.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Brotizolam.Approved, Investigational, Withdrawn
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Chloral hydrate.Approved, Investigational
BuprenorphineChloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Chloral hydrate.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Chloral hydrate.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Butacaine.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Butalbital is combined with Chloral hydrate.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Butamben.Approved, Withdrawn
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Chloral hydrate.Approved, Illicit
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Chloral hydrate.Approved, Illicit, Vet Approved
CanertinibThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Canertinib.Investigational
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Chloral hydrate.Approved, Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when Carbinoxamine is combined with Chloral hydrate.Approved
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Chloral hydrate.Illicit, Investigational, Vet Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Carisoprodol is combined with Chloral hydrate.Approved
CetirizineThe risk or severity of adverse effects can be increased when Cetirizine is combined with Chloral hydrate.Approved
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Chloral hydrate.Approved, Illicit, Investigational
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Chloral hydrate.Approved, Investigational, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Chloral hydrate.Approved
ChlorphenamineThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Chloral hydrate.Approved
ChlorpromazineThe risk or severity of adverse effects can be increased when Chlorpromazine is combined with Chloral hydrate.Approved, Investigational, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Chloral hydrate.Approved, Investigational, Withdrawn
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Chloral hydrate.Approved
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Chloral hydrate.Approved, Vet Approved
CitalopramThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Citalopram.Approved
ClemastineThe risk or severity of adverse effects can be increased when Clemastine is combined with Chloral hydrate.Approved, Investigational
ClidiniumThe risk or severity of adverse effects can be increased when Clidinium is combined with Chloral hydrate.Approved
ClobazamThe risk or severity of adverse effects can be increased when Clobazam is combined with Chloral hydrate.Approved, Illicit
clomethiazoleThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with clomethiazole.Investigational
ClomipramineThe risk or severity of adverse effects can be increased when Clomipramine is combined with Chloral hydrate.Approved, Investigational, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when Clonazepam is combined with Chloral hydrate.Approved, Illicit
ClonidineThe risk or severity of adverse effects can be increased when Clonidine is combined with Chloral hydrate.Approved
ClopenthixolThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Clopenthixol.Experimental
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Chloral hydrate.Approved, Illicit
ClorindioneThe serum concentration of Clorindione can be increased when it is combined with Chloral hydrate.Experimental
ClothiapineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Clothiapine.Experimental
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Chloral hydrate.Approved
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Chloral hydrate.Approved, Illicit
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Chloral hydrate.Approved, Illicit
CyclizineThe risk or severity of adverse effects can be increased when Cyclizine is combined with Chloral hydrate.Approved
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Chloral hydrate.Approved
CyclopropaneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Cyclopropane.Experimental
CyproheptadineThe risk or severity of adverse effects can be increased when Cyproheptadine is combined with Chloral hydrate.Approved
DantroleneThe risk or severity of adverse effects can be increased when Dantrolene is combined with Chloral hydrate.Approved, Investigational
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Chloral hydrate.Approved
DapoxetineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Dapoxetine.Investigational
DeramciclaneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Deramciclane.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Chloral hydrate.Approved
DesipramineThe risk or severity of adverse effects can be increased when Desipramine is combined with Chloral hydrate.Approved, Investigational
DesloratadineThe risk or severity of adverse effects can be increased when Desloratadine is combined with Chloral hydrate.Approved, Investigational
DesvenlafaxineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Desvenlafaxine.Approved, Investigational
DetomidineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Detomidine.Vet Approved
DeutetrabenazineThe risk or severity of sedation and somnolence can be increased when Chloral hydrate is combined with Deutetrabenazine.Approved, Investigational
DexbrompheniramineThe risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Chloral hydrate.Approved
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Chloral hydrate.Approved, Vet Approved
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Chloral hydrate.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Chloral hydrate.Approved, Illicit, Investigational, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Chloral hydrate.Approved, Investigational
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Chloral hydrate.Approved, Illicit, Investigational, Vet Approved
DicoumarolThe serum concentration of Dicoumarol can be increased when it is combined with Chloral hydrate.Approved
Diethyl etherThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Diethyl ether.Experimental
DifenoxinThe risk or severity of adverse effects can be increased when Difenoxin is combined with Chloral hydrate.Approved, Illicit
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Chloral hydrate.Approved, Illicit
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Chloral hydrate.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Dihydromorphine.Experimental, Illicit
DimenhydrinateThe risk or severity of adverse effects can be increased when Dimenhydrinate is combined with Chloral hydrate.Approved
DiphenadioneThe serum concentration of Diphenadione can be increased when it is combined with Chloral hydrate.Experimental
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Chloral hydrate.Approved, Investigational
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Chloral hydrate.Approved, Illicit
DixyrazineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Dixyrazine.Experimental
DoramectinThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Doramectin.Vet Approved
DoxepinThe risk or severity of adverse effects can be increased when Doxepin is combined with Chloral hydrate.Approved, Investigational
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with DPDPE.Experimental
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.Approved, Illicit
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.Approved, Vet Approved
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Chloral hydrate.Experimental, Illicit
DuloxetineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Duloxetine.Approved
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Chloral hydrate.Approved
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Chloral hydrate.Experimental, Illicit
EcopipamThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Ecopipam.Investigational
EfavirenzThe risk or severity of adverse effects can be increased when Efavirenz is combined with Chloral hydrate.Approved, Investigational
EltanoloneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Eltanolone.Investigational
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Chloral hydrate.Approved, Investigational, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Entacapone is combined with Chloral hydrate.Approved, Investigational
EscitalopramThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Escitalopram.Approved, Investigational
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Chloral hydrate.Approved, Illicit
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Chloral hydrate.Approved, Investigational
EthanolChloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Chloral hydrate.Approved, Illicit, Withdrawn
EthosuximideThe risk or severity of adverse effects can be increased when Ethosuximide is combined with Chloral hydrate.Approved
EthotoinThe risk or severity of adverse effects can be increased when Ethotoin is combined with Chloral hydrate.Approved
Ethyl biscoumacetateThe serum concentration of Ethyl biscoumacetate can be increased when it is combined with Chloral hydrate.Withdrawn
Ethyl carbamateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Ethyl carbamate.Withdrawn
Ethyl chlorideThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Ethyl chloride.Approved, Experimental, Investigational
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Chloral hydrate.Approved, Illicit
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Chloral hydrate.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Etidocaine.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Etifoxine.Investigational, Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Etizolam.Approved
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Chloral hydrate.Approved
EtoperidoneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Etoperidone.Withdrawn
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Chloral hydrate.Illicit, Vet Approved
EzogabineThe risk or severity of adverse effects can be increased when Ezogabine is combined with Chloral hydrate.Approved, Investigational
FelbamateThe risk or severity of adverse effects can be increased when Felbamate is combined with Chloral hydrate.Approved
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Chloral hydrate.Approved, Illicit, Withdrawn
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Chloral hydrate.Approved, Illicit, Investigational, Vet Approved
FexofenadineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Chloral hydrate.Approved, Investigational
FlibanserinThe risk or severity of adverse effects can be increased when Flibanserin is combined with Chloral hydrate.Approved, Investigational
FluanisoneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Fluanisone.Experimental
FludiazepamThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Fludiazepam.Approved, Illicit
FluindioneThe serum concentration of Fluindione can be increased when it is combined with Chloral hydrate.Approved, Investigational
FlunarizineThe risk or severity of adverse effects can be increased when Flunarizine is combined with Chloral hydrate.Approved
FlunitrazepamThe risk or severity of adverse effects can be increased when Flunitrazepam is combined with Chloral hydrate.Approved, Illicit
FluoxetineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Chloral hydrate.Approved, Investigational, Withdrawn
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Chloral hydrate.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Chloral hydrate.Approved, Illicit, Investigational
FluspirileneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Fluspirilene.Approved, Investigational
Fluticasone propionateThe risk or severity of adverse effects can be increased when Fluticasone propionate is combined with Chloral hydrate.Approved
FluvoxamineThe risk or severity of adverse effects can be increased when Fluvoxamine is combined with Chloral hydrate.Approved, Investigational
FosphenytoinThe risk or severity of adverse effects can be increased when Fosphenytoin is combined with Chloral hydrate.Approved, Investigational
FospropofolThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Fospropofol.Approved, Illicit, Investigational
FurosemideThe risk or severity of adverse effects can be increased when Furosemide is combined with Chloral hydrate.Approved, Vet Approved
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Chloral hydrate.Approved, Investigational
Gabapentin EnacarbilThe risk or severity of adverse effects can be increased when Gabapentin Enacarbil is combined with Chloral hydrate.Approved, Investigational
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Chloral hydrate.Approved, Illicit, Investigational
GepironeThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Gepirone.Investigational
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Chloral hydrate.Approved, Illicit
GuanfacineThe risk or severity of adverse effects can be increased when Guanfacine is combined with Chloral hydrate.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Chloral hydrate.Approved, Illicit, Withdrawn
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with Chloral hydrate.Approved
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Chloral hydrate.Approved, Vet Approved
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Chloral hydrate.Approved, Illicit, Investigational
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Chloral hydrate.Approved
HydrocodoneChloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Chloral hydrate.Approved, Illicit
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.Approved
IloperidoneThe risk or severity of adverse effects can be increased when Iloperidone is combined with Chloral hydrate.Approved
ImipramineThe risk or severity of adverse effects can be increased when Imipramine is combined with Chloral hydrate.Approved
IndalpineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Indalpine.Investigational, Withdrawn
IndiplonThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Indiplon.Investigational
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Chloral hydrate.Approved, Vet Approved
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Chloral hydrate.Approved, Vet Approved
KetazolamThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Ketazolam.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Ketobemidone.Approved, Investigational
LamotrigineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Chloral hydrate.Approved, Investigational
LevetiracetamThe risk or severity of adverse effects can be increased when Levetiracetam is combined with Chloral hydrate.Approved, Investigational
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Chloral hydrate.Approved, Investigational
LevocabastineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Levocabastine.Approved, Investigational
LevocetirizineThe risk or severity of adverse effects can be increased when Levocetirizine is combined with Chloral hydrate.Approved
LevodopaThe risk or severity of adverse effects can be increased when Levodopa is combined with Chloral hydrate.Approved
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Chloral hydrate.Approved, Investigational
LevomilnacipranThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Levomilnacipran.Approved, Investigational
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Chloral hydrate.Approved
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Chloral hydrate.Approved, Vet Approved
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with Chloral hydrate.Approved
LofentanilThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Lofentanil.Illicit
LofexidineThe therapeutic efficacy of Chloral hydrate can be increased when used in combination with Lofexidine.Approved, Investigational
LoprazolamThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Loprazolam.Experimental
LoratadineThe risk or severity of adverse effects can be increased when Loratadine is combined with Chloral hydrate.Approved, Investigational
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Chloral hydrate.Approved
LormetazepamThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Lormetazepam.Approved
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Chloral hydrate.Approved
LurasidoneThe risk or severity of adverse effects can be increased when Lurasidone is combined with Chloral hydrate.Approved, Investigational
Magnesium sulfateThe therapeutic efficacy of Chloral hydrate can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
MaprotilineThe risk or severity of adverse effects can be increased when Maprotiline is combined with Chloral hydrate.Approved, Investigational
MebicarThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Mebicar.Experimental
MeclizineThe risk or severity of adverse effects can be increased when Meclizine is combined with Chloral hydrate.Approved
MedazepamThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Medazepam.Experimental
MedetomidineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Medetomidine.Vet Approved
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Chloral hydrate.Approved, Nutraceutical, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Melperone.Approved, Investigational
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Chloral hydrate.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Chloral hydrate.Approved, Illicit
MeptazinolThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Meptazinol.Experimental
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Chloral hydrate.Approved, Investigational
MetaxaloneThe risk or severity of adverse effects can be increased when Metaxalone is combined with Chloral hydrate.Approved
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Chloral hydrate.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Chloral hydrate.Approved, Illicit
MethapyrileneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Methapyrilene.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Methaqualone.Illicit, Withdrawn
MethocarbamolThe risk or severity of adverse effects can be increased when Methocarbamol is combined with Chloral hydrate.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Chloral hydrate.Approved
MethotrimeprazineChloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved, Investigational
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Chloral hydrate.Approved, Investigational, Vet Approved
MethsuximideThe risk or severity of adverse effects can be increased when Methsuximide is combined with Chloral hydrate.Approved
MethylecgonineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Methylecgonine.Experimental
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Chloral hydrate.Approved
MetyrosineChloral hydrate may increase the sedative activities of Metyrosine.Approved
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Chloral hydrate.Approved, Illicit
MilnacipranThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Milnacipran.Approved, Investigational
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.Approved, Investigational
MirtazapineChloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MolindoneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Molindone.Approved
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Chloral hydrate.Approved, Investigational
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.Approved, Investigational
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Chloral hydrate.Approved
NefazodoneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Nefazodone.Approved, Withdrawn
NitrazepamThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Chloral hydrate.Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Chloral hydrate.Approved, Vet Approved
NordazepamThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Nordazepam.Approved
NorfluraneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Norflurane.Approved, Investigational
NormethadoneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Normethadone.Approved, Illicit
NortriptylineThe risk or severity of adverse effects can be increased when Nortriptyline is combined with Chloral hydrate.Approved
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Chloral hydrate.Approved, Investigational
OlopatadineThe risk or severity of adverse effects can be increased when Olopatadine is combined with Chloral hydrate.Approved
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Chloral hydrate.Approved
OpiumThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Opium.Approved, Illicit
OrphenadrineChloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Osanetant.Investigational
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Chloral hydrate.Approved
OxprenololThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Oxprenolol.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Chloral hydrate.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Chloral hydrate.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Chloral hydrate.Approved, Investigational, Vet Approved
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Chloral hydrate.Approved
ParaldehydeChloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
ParoxetineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Paroxetine.Approved, Investigational
PenfluridolThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Penfluridol.Experimental
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Chloral hydrate.Approved, Vet Approved
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Chloral hydrate.Approved, Investigational, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.Approved
PerazineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Perazine.Approved, Investigational
PerospironeThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Perospirone.Approved
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Chloral hydrate.Approved
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Chloral hydrate.Approved
PhenazocineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Phenazocine.Experimental
PhenibutThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Phenibut.Experimental
PhenindioneThe serum concentration of Phenindione can be increased when it is combined with Chloral hydrate.Approved, Investigational
PhenobarbitalThe risk or severity of adverse effects can be increased when Phenobarbital is combined with Chloral hydrate.Approved, Investigational
PhenoperidineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Phenoperidine.Experimental
PhenoxyethanolThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Phenoxyethanol.Approved
PhenprocoumonThe serum concentration of Phenprocoumon can be increased when it is combined with Chloral hydrate.Approved, Investigational
PhenytoinThe risk or severity of adverse effects can be increased when Phenytoin is combined with Chloral hydrate.Approved, Vet Approved
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Chloral hydrate.Approved
PipamperoneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Pipamperone.Approved, Investigational
PipotiazineThe risk or severity of adverse effects can be increased when Pipotiazine is combined with Chloral hydrate.Approved, Investigational
PiritramideThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Piritramide.Approved, Investigational
PizotifenThe risk or severity of adverse effects can be increased when Pizotifen is combined with Chloral hydrate.Approved
PomalidomideThe risk or severity of adverse effects can be increased when Pomalidomide is combined with Chloral hydrate.Approved
PramipexoleChloral hydrate may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Pramocaine.Approved
PrazepamThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Prazepam.Approved, Illicit
PregabalinThe therapeutic efficacy of Chloral hydrate can be increased when used in combination with Pregabalin.Approved, Illicit, Investigational
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Chloral hydrate.Approved
PrimidoneThe risk or severity of adverse effects can be increased when Primidone is combined with Chloral hydrate.Approved, Vet Approved
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Chloral hydrate.Approved, Investigational, Vet Approved
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Chloral hydrate.Approved, Vet Approved
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Chloral hydrate.Approved, Vet Approved
PromethazineThe risk or severity of adverse effects can be increased when Promethazine is combined with Chloral hydrate.Approved, Investigational
PropanididThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Propanidid.Experimental
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Chloral hydrate.Approved, Vet Approved
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Chloral hydrate.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Propoxycaine.Approved
ProtriptylineThe risk or severity of adverse effects can be increased when Protriptyline is combined with Chloral hydrate.Approved
ProxibarbalThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Proxibarbal.Experimental
PSD502The risk or severity of adverse effects can be increased when Chloral hydrate is combined with PSD502.Investigational
QuazepamThe risk or severity of adverse effects can be increased when Quazepam is combined with Chloral hydrate.Approved, Illicit
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Chloral hydrate.Approved
QuinisocaineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Quinisocaine.Experimental
RacloprideThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Raclopride.Investigational
RamelteonThe risk or severity of adverse effects can be increased when Ramelteon is combined with Chloral hydrate.Approved, Investigational
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Chloral hydrate.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Chloral hydrate.Approved, Withdrawn
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Chloral hydrate.Approved, Investigational
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Chloral hydrate.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Ritanserin.Investigational
RomifidineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Romifidine.Vet Approved
RopiniroleChloral hydrate may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Chloral hydrate.Approved
RotigotineChloral hydrate may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Chloral hydrate.Approved
ScopolamineThe risk or severity of adverse effects can be increased when Scopolamine is combined with Chloral hydrate.Approved, Investigational
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Chloral hydrate.Approved, Vet Approved
SepranoloneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Sepranolone.Investigational
SertindoleThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Sertindole.Approved, Investigational, Withdrawn
SertralineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Chloral hydrate.Approved, Vet Approved
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.Approved
StiripentolThe risk or severity of adverse effects can be increased when Stiripentol is combined with Chloral hydrate.Approved
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Chloral hydrate.Approved, Investigational
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Chloral hydrate.Approved, Investigational
SultoprideThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Sultopride.Experimental
SuvorexantChloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved, Investigational
TandospironeThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Tasimelteon is combined with Chloral hydrate.Approved, Investigational
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Chloral hydrate.Approved, Investigational
TetrabenazineThe risk or severity of adverse effects can be increased when Tetrabenazine is combined with Chloral hydrate.Approved, Investigational
TetracaineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Tetracaine.Approved, Vet Approved
TetrahydropalmatineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Tetrahydropalmatine.Investigational
TetrodotoxinThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Tetrodotoxin.Investigational
ThalidomideChloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Chloral hydrate.Approved, Vet Approved
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Chloral hydrate.Approved, Vet Approved
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Chloral hydrate.Approved, Withdrawn
ThiothixeneThe risk or severity of adverse effects can be increased when Thiothixene is combined with Chloral hydrate.Approved
TiagabineThe risk or severity of adverse effects can be increased when Tiagabine is combined with Chloral hydrate.Approved, Investigational
TiaprideThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Tiapride.Approved, Investigational
TiletamineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Tiletamine.Vet Approved
TilidineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Tilidine.Experimental
TioclomarolThe serum concentration of Tioclomarol can be increased when it is combined with Chloral hydrate.Experimental
TizanidineThe risk or severity of adverse effects can be increased when Tizanidine is combined with Chloral hydrate.Approved, Investigational
TolcaponeThe risk or severity of adverse effects can be increased when Tolcapone is combined with Chloral hydrate.Approved, Withdrawn
TopiramateThe risk or severity of adverse effects can be increased when Topiramate is combined with Chloral hydrate.Approved
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Chloral hydrate.Approved, Investigational
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Chloral hydrate.Approved, Investigational
TrazodoneThe risk or severity of adverse effects can be increased when Trazodone is combined with Chloral hydrate.Approved, Investigational
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Chloral hydrate.Approved, Investigational
Tricaine methanesulfonateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Tricaine methanesulfonate.Vet Approved
TrichloroethyleneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Trichloroethylene.Approved
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Chloral hydrate.Approved, Investigational
TrifluperidolThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Trifluperidol.Experimental
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Chloral hydrate.Approved, Vet Approved
TrimipramineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Chloral hydrate.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Triprolidine is combined with Chloral hydrate.Approved
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Chloral hydrate.Approved, Investigational
VenlafaxineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Venlafaxine.Approved
VeraliprideThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Veralipride.Experimental
VigabatrinThe risk or severity of adverse effects can be increased when Vigabatrin is combined with Chloral hydrate.Approved
Vinyl etherThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Vinyl ether.Experimental
VortioxetineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Vortioxetine.Approved, Investigational
WarfarinThe serum concentration of Warfarin can be increased when it is combined with Chloral hydrate.Approved
XenonThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Xenon.Experimental
XylazineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Xylazine.Vet Approved
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Chloral hydrate.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Ziconotide is combined with Chloral hydrate.Approved
ZimelidineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Zimelidine.Withdrawn
ZiprasidoneThe risk or severity of adverse effects can be increased when Ziprasidone is combined with Chloral hydrate.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Zolazepam.Vet Approved
ZolpidemChloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe risk or severity of adverse effects can be increased when Zonisamide is combined with Chloral hydrate.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Chloral hydrate.Approved
ZotepineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Zotepine.Approved, Investigational, Withdrawn
ZuclopenthixolThe risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Chloral hydrate.Approved, Investigational
Food Interactions
Not Available

References

General References
Not Available
External Links
Human Metabolome Database
HMDB0060451
KEGG Drug
D00265
KEGG Compound
C06899
PubChem Compound
2707
PubChem Substance
46507155
ChemSpider
2606
ChEBI
28142
ChEMBL
CHEMBL455917
PharmGKB
PA448925
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Chloral_hydrate
ATC Codes
N05CC01 — Chloral hydrate
AHFS Codes
  • 28:24.92 — Miscellaneous Anxiolytics Sedatives and Hypnotics

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2CompletedNot AvailableAuditory Brainstem Response in Children / Sedation With Chloral Hydrate1
2WithdrawnDiagnosticComputerized tomography / Procedural Sedation / Traumatic Brain Injury (TBI)1
2WithdrawnTreatmentProcedural Sedation1
3CompletedDiagnosticChildren / Electroencephalogram / Epilepsies / Sedation therapy1
3CompletedTreatmentOther Conditions of Brain1
3TerminatedTreatmentAnxiety Disorders / Dementias / Depression / Psychosomatic Disorders / Schizophrenic Disorders1
4CompletedTreatmentHeart Diseases1
4CompletedTreatmentSedation therapy1
Not AvailableCompletedNot AvailablePediatric1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
  • Amerifit Inc.
  • Bio Pharm Inc.
  • Breckenridge Pharmaceuticals
  • Dispensing Solutions
  • G & W Labs
  • G Pohl Boskamp GmbH and Co. KG
  • International Laboratories Inc.
  • Letco Medical Inc.
  • Major Pharmaceuticals
  • Pharmaceutical Association
  • Pharmascience Inc.
  • Physicians Total Care Inc.
  • Qualitest
  • United Research Laboratories Inc.
  • Vintage Pharmaceuticals Inc.
Dosage forms
FormRouteStrength
SyrupOral100 mg
OintmentTopical
CapsuleOral500 mg
SyrupOral500 mg
Prices
Unit descriptionCostUnit
Pms-Chloral Hydrate 100 mg/ml Syrup0.05USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)57 °CPhysProp
boiling point (°C)98 °CPhysProp
water solubility7.93E+005 mg/L (at 25 °C)YALKOWSKY,SH & HE,Y (2003)
logP0.99HANSCH,C ET AL. (1995)
Predicted Properties
PropertyValueSource
Water Solubility43.4 mg/mLALOGPS
logP0.88ALOGPS
logP0.69ChemAxon
logS-0.58ALOGPS
pKa (Strongest Acidic)9.51ChemAxon
pKa (Strongest Basic)-5.1ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area40.46 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity29.25 m3·mol-1ChemAxon
Polarizability11.88 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9591
Blood Brain Barrier+0.9555
Caco-2 permeable-0.5795
P-glycoprotein substrateNon-substrate0.8757
P-glycoprotein inhibitor INon-inhibitor0.9923
P-glycoprotein inhibitor IINon-inhibitor0.9794
Renal organic cation transporterNon-inhibitor0.9454
CYP450 2C9 substrateNon-substrate0.7898
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateNon-substrate0.7558
CYP450 1A2 substrateNon-inhibitor0.7969
CYP450 2C9 inhibitorNon-inhibitor0.8017
CYP450 2D6 inhibitorNon-inhibitor0.9417
CYP450 2C19 inhibitorNon-inhibitor0.847
CYP450 3A4 inhibitorNon-inhibitor0.9446
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9778
Ames testAMES toxic0.6454
CarcinogenicityCarcinogens 0.616
BiodegradationNot ready biodegradable0.8453
Rat acute toxicity2.5068 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9837
hERG inhibition (predictor II)Non-inhibitor0.9558
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Download (8.88 KB)
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as chlorohydrins. These are alcohols substituted by a chlorine atom at a saturated carbon atom otherwise bearing only hydrogen or hydrocarbyl groups.
Kingdom
Organic compounds
Super Class
Organohalogen compounds
Class
Halohydrins
Sub Class
Chlorohydrins
Direct Parent
Chlorohydrins
Alternative Parents
Carbonyl hydrates / Organochlorides / Hydrocarbon derivatives / Alkyl chlorides
Substituents
Chlorohydrin / Carbonyl hydrate / Organic oxygen compound / Hydrocarbon derivative / Organooxygen compound / Organochloride / Alkyl halide / Alkyl chloride / Aliphatic acyclic compound
Molecular Framework
Aliphatic acyclic compounds
External Descriptors
organochlorine compound, aldehyde hydrate, ethanediol (CHEBI:28142) / a small molecule (CPD0-1476)

Drug created on July 31, 2007 07:10 / Updated on June 21, 2018 00:00