Antiglaucoma Preparations and Miotics

DrugDrug NameDrug Indication
DB00195BetaxololFor the management of hypertension.
DB00287TravoprostOphthalmic solution used for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension who are intolerant of other intraocular pressure lowering medications or insufficiently responsive (failed to achieve target IOP determined after multiple measurements over time) to another intraocular pressure lowering medication.
DB00298DapiprazoleUsed in the treatment of iatrogenically induced mydriasis produced by adrenergic (phenylephrine) or parasympatholytic (tropicamide) agents used in certain eye examinations.
DB00411CarbamoylcholinePrimarily used in the treatment of glaucoma, but is also used during ophthalmic surgery.
DB00449DipivefrinDipivefrin is a prodrug which is used as initial therapy for the control of intraocular pressure in chronic open-angle glaucoma.
DB00654LatanoprostFor the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
DB00703MethazolamideFor treatment of chronic open-angle glaucoma and acute angle-closure glaucoma
DB00819AcetazolamideFor adjunctive treatment of: edema due to congestive heart failure; drug-induced edema; centrencephalic epilepsies; chronic simple (open-angle) glaucoma
DB00869DorzolamideFor the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. Also used prophylatically for the inhibition of perioperative IOP increase (before neodynium yttrium aluminum garnet laser posterior capsulotomy).
DB00905BimatoprostFor the reduction of elevated intraocular pressure in patients with open angle glaucoma or ocular hypertension who are intolerant of other intraocular pressure lowering medications or insufficiently responsive (failed to achieve target IOP determined after multiple measurements over time) to another intraocular pressure lowering medication.
DB00944DemecariumFor the topical treatment of chronic open-angle glaucoma.
DB00964ApraclonidineFor prevention or reduction of intraoperative and postoperative increases in intraocular pressure (IOP) before and after ocular laser surgery when used prophylactically. Also used as a short-term adjunctive therapy in patients with open-angle glaucoma who are on maximally tolerated medical therapy requiring additional IOP reduction.
DB01057EchothiophateFor use in the treatment of subacute or chronic angle-closure glaucoma after iridectomy or where surgery is refused or contraindicated.
DB01170GuanethidineFor the treatment of moderate and severe hypertension, either alone or as an adjunct, and for the treatment of renal hypertension.
DB01194BrinzolamideFor the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
DB01210LevobunololFor lowering intraocular pressure (IOP) and may be used in patients with chronic open-angle glaucoma or ocular hypertension.
DB01214MetipranololIndicated in the treatment of elevated intraocular pressure in patients with ocular hypertension or open angle glaucoma.
DB03128AcetylcholineUsed to obtain miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required.
DB06826UnoprostoneFor the lowering of intraocular pressure in patients with open-angle glaucoma or ocular hypertension who are intolerant of other intraocular pressure lowering medications or insufficiently responsive (failed to achieve target IOP determined after multiple measurements over time) to another intraocular pressure lowering medication.
DB08819TafluprostTafluprost is indicated for reducing elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
DB09013BefunololUsed in the management of open angle glaucoma. PMID: 12480285.
DB00373TimololIn its oral form it is used to treat high blood pressure and prevent heart attacks, and occasionally to prevent migraine headaches. In its opthalmic form it is used to treat open-angle and occasionally secondary glaucoma.
DB00484BrimonidineThe ophthalmic solution is indicated for patients with open-angle glaucoma or ocular hypertension to lower intraocular pressure. The topical gel is indicated for the treatment of persistent (nontransient) facial erythema of rosacea in adults 18 years or older.
DB00521CarteololFor the treatment of intraocular hypertension and chronic open-angle glaucoma
DB00575ClonidineMay be used as an adjunct in the treatment of hypertension, as an epidural infusion as an adjunct treatment in the management of severe cancer pain that is not relieved by opiate analgesics alone, for differential diagnosis of pheochromocytoma in hypertensive patients, prophylaxis of vascular migraine headaches, treatment of severe dysmenorrhea, management of vasomotor symptoms associated with menopause, rapid detoxification in the management of opiate withdrawal, treatment of alcohol withdrawal used in conjunction with benzodiazepines, management of nicotine dependence, topical use to reduce intraocular pressure in the treatment of open-angle and secondary glaucoma and hemorrhagic glaucoma associated with hypertension, and in the treatment of attention-deficit hyperactivity disorder (ADHD).
DB00668EpinephrineEpinephrine injection is indicated in the emergency treatment of allergic reactions (Type I) including anaphylaxis to stinging insects (e.g., order Hymenoptera, which include bees, wasps, hornets, yellow jackets and fire ants) and biting insects (e.g., triatoma, mosquitos), allergen immunotherapy, foods, drugs, diagnostic testing substances (e.g., radiocontrast media) and other allergens, as well as idiopathic anaphylaxis or exercise-induced anaphylaxis. Injectable epinephrine is intended for immediate/urgent administration in patients, who are found to be at increased risk for anaphylaxis, including individuals with a history of anaphylaxis. Selection of the appropriate dosage strength is determined according to body weight [FDA label]. Its cardiac effects may be of use in restoring cardiac rhythm in cardiac arrest due to various causes, but is not used in cardiac failure or in hemorrhagic, traumatic, or cardiogenic shock [F1247]. Epinephrine is used as a hemostatic agent. It is also used in treating mucosal congestion of hay fever, rhinitis, and acute sinusitis; to relieve bronchial asthmatic paroxysms; in syncope due to complete heart block or carotid sinus hypersensitivity; for symptomatic relief of serum sickness, urticaria, angioneurotic edema; for resuscitation in cardiac arrest following anesthetic accidents; in simple (open angle) glaucoma; for relaxation of uterine musculature and to inhibit uterine contractions. Epinephrine injection can be utilized to prolong the action of local anesthetics [F1247].
DB00981PhysostigmineFor the treatment of glaucoma, and in the treatment of severe anticholinergic toxicity.
DB01085PilocarpineFor the treatment of radiation-induced dry mouth (xerostomia) and symptoms of dry mouth in patients with Sjögrens syndrome.
DB01144DiclofenamideFor adjunctive treatment of: chronic simple (open-angle) glaucoma, secondary glaucoma, and preoperatively in acute angle-closure glaucoma where delay of surgery is desired in order to lower intraocular pressure
DB01400NeostigmineNeostigmine is used for the symptomatic treatment of myasthenia gravis by improving muscle tone.
DrugDrug NameTargetType
DB00195BetaxololBeta-1 adrenergic receptortarget
DB00195BetaxololBeta-2 adrenergic receptortarget
DB00195BetaxololCytochrome P450 1A2enzyme
DB00195BetaxololCytochrome P450 2D6enzyme
DB00287TravoprostProstaglandin F2-alpha receptortarget
DB00298DapiprazoleAlpha-1A adrenergic receptortarget
DB00298DapiprazoleAlpha-1D adrenergic receptortarget
DB00298DapiprazoleAlpha-1B adrenergic receptortarget
DB00411CarbamoylcholineMuscarinic acetylcholine receptor M1target
DB00411CarbamoylcholineMuscarinic acetylcholine receptor M2target
DB00411CarbamoylcholineNeuronal acetylcholine receptor subunit alpha-2target
DB00411CarbamoylcholineCytosolic phospholipase A2enzyme
DB00411CarbamoylcholineAcetylcholinesterasetarget
DB00411CarbamoylcholineMuscarinic acetylcholine receptor M3target
DB00411CarbamoylcholineMuscarinic acetylcholine receptor M4target
DB00449DipivefrinAlpha-2A adrenergic receptortarget
DB00449DipivefrinCholinesterasetarget
DB00449DipivefrinBeta-2 adrenergic receptortarget
DB00449DipivefrinAlpha-1A adrenergic receptortarget
DB00449DipivefrinAcetylcholinesterasetarget
DB00654LatanoprostProstaglandin F2-alpha receptortarget
DB00654LatanoprostSolute carrier organic anion transporter family member 2B1transporter
DB00654LatanoprostSolute carrier family 22 member 1transporter
DB00703MethazolamideCarbonic anhydrase 1target
DB00703MethazolamideSolute carrier family 22 member 6transporter
DB00703MethazolamideCytochrome P450 2C19enzyme
DB00703MethazolamideCytochrome P450 2C9enzyme
DB00703MethazolamideCytochrome P450 2D6enzyme
DB00703MethazolamideCytochrome P450 2E1enzyme
DB00703MethazolamideCytochrome P450 3A4enzyme
DB00703MethazolamideCarbonic anhydrase 4target
DB00703MethazolamideCarbonic anhydrase 2target
DB00703MethazolamideCarbonic anhydrase 7target
DB00703MethazolamideCarbonic anhydrase 3target
DB00819AcetazolamideCarbonic anhydrase 1target
DB00819AcetazolamideAquaporin-1target
DB00819AcetazolamideCarbonic anhydrase 14target
DB00819AcetazolamideSolute carrier family 22 member 6transporter
DB00819AcetazolamideCarbonic anhydrase 2target
DB00819AcetazolamideCarbonic anhydrase 3target
DB00819AcetazolamideCarbonic anhydrase 4target
DB00819AcetazolamideCytochrome P450 3A4enzyme
DB00819AcetazolamideCarbonic anhydrase 7target
DB00819AcetazolamideCarbonic anhydrase 12target
DB00869DorzolamideCarbonic anhydrase 2target
DB00869DorzolamideCarbonic anhydrase 1target
DB00869DorzolamideCarbonic anhydrase 4target
DB00869DorzolamideCytochrome P450 2C9enzyme
DB00869DorzolamideCytochrome P450 3A4enzyme
DB00869DorzolamideCarbonic anhydrase 3target
DB00905BimatoprostProstaglandin F2-alpha receptortarget
DB00905BimatoprostProstaglandin E2 receptor EP1 subtypetarget
DB00905BimatoprostProstaglandin E2 receptor EP3 subtypetarget
DB00905BimatoprostAldo-keto reductase family 1 member C3target
DB00944DemecariumAcetylcholinesterasetarget
DB00944DemecariumCholinesterasetarget
DB00964ApraclonidineAlpha-2A adrenergic receptortarget
DB00964ApraclonidineAlpha-1A adrenergic receptortarget
DB00964ApraclonidineAlpha-2B adrenergic receptortarget
DB01057EchothiophateCholinesterasetarget
DB01057EchothiophateSerum albumincarrier
DB01170GuanethidineSodium-dependent noradrenaline transportertarget
DB01170GuanethidineCytochrome P450 3A4enzyme
DB01194BrinzolamideCarbonic anhydrase 1target
DB01194BrinzolamideCarbonic anhydrase 2target
DB01194BrinzolamideCytochrome P450 3A4enzyme
DB01194BrinzolamideCarbonic anhydrase 5A, mitochondrialtarget
DB01194BrinzolamideCarbonic anhydrase 4target
DB01194BrinzolamideCarbonic anhydrase 3target
DB01210LevobunololBeta-1 adrenergic receptortarget
DB01210LevobunololBeta-2 adrenergic receptortarget
DB01210LevobunololCytochrome P450 2D6enzyme
DB01214MetipranololBeta-1 adrenergic receptortarget
DB01214MetipranololBeta-2 adrenergic receptortarget
DB01214MetipranololCytochrome P450 2D6enzyme
DB03128AcetylcholineAcetylcholinesterasetarget
DB03128AcetylcholineSolute carrier family 22 member 5transporter
DB03128AcetylcholineSolute carrier family 22 member 1transporter
DB03128AcetylcholineCytochrome P450 2D6enzyme
DB03128AcetylcholineMuscarinic acetylcholine receptor M1target
DB03128AcetylcholineMuscarinic acetylcholine receptor M2target
DB03128AcetylcholineMuscarinic acetylcholine receptor M3target
DB03128AcetylcholineMuscarinic acetylcholine receptor M4target
DB03128AcetylcholineNeuronal acetylcholine receptor subunit alpha-7target
DB08819TafluprostProstaglandin F2-alpha receptortarget
DB08819TafluprostProstaglandin G/H synthase 2enzyme
DB09013BefunololBeta-1 adrenergic receptortarget
DB09013BefunololBeta-2 adrenergic receptortarget
DB09013BefunololCytochrome P450 2D6enzyme
DB00373TimololBeta-1 adrenergic receptortarget
DB00373TimololBeta-2 adrenergic receptortarget
DB00373TimololCytochrome P450 2D6enzyme
DB00373TimololMultidrug resistance protein 1transporter
DB00373TimololCytochrome P450 2C19enzyme
DB00373TimololLysozymetarget
DB00484BrimonidineAlpha-2A adrenergic receptortarget
DB00484BrimonidineAlpha-2B adrenergic receptortarget
DB00484BrimonidineAlpha-2C adrenergic receptortarget
DB00484BrimonidineAldehyde oxidaseenzyme
DB00521CarteololBeta-2 adrenergic receptortarget
DB00521CarteololBeta-1 adrenergic receptortarget
DB00521CarteololCytochrome P450 2D6enzyme
DB00575ClonidineAlpha-2A adrenergic receptortarget
DB00575ClonidineCytochrome P450 2D6enzyme
DB00575ClonidineAlpha-2B adrenergic receptortarget
DB00575ClonidineAlpha-2C adrenergic receptortarget
DB00575ClonidineSolute carrier family 22 member 1transporter
DB00575ClonidineSolute carrier family 22 member 3transporter
DB00575ClonidineSolute carrier family 22 member 5transporter
DB00575ClonidineSolute carrier family 22 member 4transporter
DB00575ClonidineMultidrug resistance protein 1transporter
DB00575ClonidineCytochrome P450 1A2enzyme
DB00575ClonidineCytochrome P450 3A4enzyme
DB00575ClonidineCytochrome P450 1A1enzyme
DB00575ClonidineCytochrome P450 3A5enzyme
DB00575ClonidineAlpha-1A adrenergic receptortarget
DB00575ClonidineAlpha-1B adrenergic receptortarget
DB00575ClonidineAlpha-1D adrenergic receptortarget
DB00668EpinephrineAlpha-1A adrenergic receptortarget
DB00668EpinephrineBeta-1 adrenergic receptortarget
DB00668EpinephrineBeta-2 adrenergic receptortarget
DB00668EpinephrineSolute carrier family 22 member 2transporter
DB00668EpinephrineSolute carrier family 22 member 1transporter
DB00668EpinephrineCytochrome P450 1A2enzyme
DB00668EpinephrineCytochrome P450 2C9enzyme
DB00668EpinephrineCytochrome P450 3A4enzyme
DB00668EpinephrineAlpha-1B adrenergic receptortarget
DB00668EpinephrineAlpha-1D adrenergic receptortarget
DB00668EpinephrineAlpha-2A adrenergic receptortarget
DB00668EpinephrineAlpha-2B adrenergic receptortarget
DB00668EpinephrineTumor necrosis factortarget
DB00668EpinephrineCatechol O-methyltransferaseenzyme
DB00668EpinephrineMonoamine oxidaseenzyme
DB00981PhysostigmineAcetylcholinesterasetarget
DB00981PhysostigmineNeuronal acetylcholine receptor subunit alpha-4target
DB00981PhysostigmineNeuronal acetylcholine receptor subunit beta-2target
DB01085PilocarpineMuscarinic acetylcholine receptor M1target
DB01085PilocarpineMuscarinic acetylcholine receptor M2target
DB01085PilocarpineCytochrome P450 2A6enzyme
DB01085PilocarpineMuscarinic acetylcholine receptor M3target
DB01085PilocarpineCytochrome P450 2E1enzyme
DB01085PilocarpineCytochrome P450 3A4enzyme
DB01085PilocarpineMuscarinic acetylcholine receptor M4target
DB01144DiclofenamideCarbonic anhydrase 1target
DB01144DiclofenamideCytochrome P450 2C9enzyme
DB01144DiclofenamideCarbonic anhydrase 4target
DB01144DiclofenamideCarbonic anhydrase 2target
DB01144DiclofenamideCarbonic anhydrase 7target
DB01144DiclofenamideCarbonic anhydrase 3target
DB01400NeostigmineAcetylcholinesterasetarget
DB01400NeostigmineCholinesteraseenzyme