Miscellaneous Anxiolytics Sedatives and Hypnotics

DrugDrug NameDrug Indication
DB00402EszopicloneEszopiclone is indicated for the treatment of insomnia.[L6769]
DB00425ZolpidemThis drug is indicated for the short-term treatment of insomnia in adults characterized by difficulties with sleep initiation [FDA label].
DB00450DroperidolDroperidol is ssed to produce tranquilization and to reduce the incidence of nausea and vomiting in surgical and diagnostic procedures.
DB00490BuspironeIndicated for the management of anxiety disorders or the short-term relief of the symptoms of anxiety.[L4478]
DB00557HydroxyzineFor symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria.
DB00633DexmedetomidineFor sedation of initially intubated and mechanically ventilated patients during treatment in an intensive care setting, also used in pain relief; anxiety reduction and analgesia
DB00962ZaleplonFor the treatment of short-term treatment of insomnia in adults.
DB01069PromethazineFor the treatment of allergic disorders, and nausea/vomiting.
DB01198ZopicloneFor the short-term treatment of insomnia.
DB01563Chloral hydrateMainly used as a hypnotic in the treatment of insomnia; however, it is only effective as a hypnotic for short-term use. May be used as a routine sedative preoperatively to decrease anxiety and cause sedation and/or sleep with respiration depression or cough reflex.
DB13196ValerianNot Available
DB09034SuvorexantSuvorexant is indicated for the treatment of insomnia characterized by difficulties with sleep onset and/or sleep maintenance.
DrugDrug NameTargetType
DB00402EszopicloneCytochrome P450 3A4enzyme
DB00402EszopicloneGamma-aminobutyric acid receptor subunit alpha-1target
DB00402EszopicloneGamma-aminobutyric acid receptor subunit alpha-2target
DB00402EszopicloneGamma-aminobutyric acid receptor subunit alpha-3target
DB00402EszopicloneGamma-aminobutyric acid receptor subunit alpha-5target
DB00402EszopicloneCytochrome P450 2C8enzyme
DB00402EszopicloneGABA-A receptor (anion channel)target
DB00425ZolpidemGamma-aminobutyric acid receptor subunit alpha-1target
DB00425ZolpidemCytochrome P450 3A4enzyme
DB00425ZolpidemCytochrome P450 1A2enzyme
DB00425ZolpidemGamma-aminobutyric acid receptor subunit alpha-2target
DB00425ZolpidemGamma-aminobutyric acid receptor subunit alpha-3target
DB00425ZolpidemCytochrome P450 2C9enzyme
DB00425ZolpidemCytochrome P450 2C19enzyme
DB00425ZolpidemCytochrome P450 2D6enzyme
DB00425ZolpidemGamma-aminobutyric acid receptor subunit gamma-2target
DB00450DroperidolD(2) dopamine receptortarget
DB00450DroperidolAlpha-1A adrenergic receptortarget
DB00490Buspirone5-hydroxytryptamine receptor 1Atarget
DB00490BuspironeD(2) dopamine receptortarget
DB00490BuspironeCytochrome P450 3A4enzyme
DB00490BuspironeCytochrome P450 3A5enzyme
DB00490BuspironeCytochrome P450 3A7enzyme
DB00490BuspironeMultidrug resistance protein 1transporter
DB00490BuspironeCytochrome P450 2D6enzyme
DB00490BuspironeSerum albumincarrier
DB00490BuspironeAlpha-1-acid glycoprotein 1carrier
DB00490BuspironeD(3) dopamine receptortarget
DB00490BuspironeD(4) dopamine receptortarget
DB00490BuspironeAlpha-1 adrenergic receptorstarget
DB00557HydroxyzineHistamine H1 receptortarget
DB00557HydroxyzineCytochrome P450 2D6enzyme
DB00633DexmedetomidineAlpha-2A adrenergic receptortarget
DB00633DexmedetomidineCytochrome P450 2E1enzyme
DB00633DexmedetomidineCytochrome P450 1A2enzyme
DB00633DexmedetomidineCytochrome P450 1A1enzyme
DB00633DexmedetomidineCytochrome P450 2D6enzyme
DB00962ZaleplonTranslocator proteintarget
DB00962ZaleplonGamma-aminobutyric acid receptor subunit alpha-1target
DB00962ZaleplonCytochrome P450 3A4enzyme
DB00962ZaleplonAldehyde oxidaseenzyme
DB00962ZaleplonCytochrome P450 3A5enzyme
DB00962ZaleplonCytochrome P450 3A7enzyme
DB01069PromethazineD(2) dopamine receptortarget
DB01069PromethazineHistamine H1 receptortarget
DB01069PromethazineMuscarinic acetylcholine receptor M4target
DB01069PromethazineMuscarinic acetylcholine receptor M1target
DB01069PromethazineMuscarinic acetylcholine receptor M5target
DB01069PromethazineAlpha-1A adrenergic receptortarget
DB01069Promethazine5-hydroxytryptamine receptor 2Atarget
DB01069PromethazineMuscarinic acetylcholine receptor M2target
DB01069PromethazineMuscarinic acetylcholine receptor M3target
DB01069PromethazineCalmodulintarget
DB01069PromethazineCytochrome P450 2D6enzyme
DB01069PromethazineCytochrome P450 2B6enzyme
DB01069PromethazineMultidrug resistance protein 1transporter
DB01069PromethazineCytochrome P450 2C9enzyme
DB01069PromethazineHistamine H2 receptortarget
DB01198ZopicloneTranslocator proteintarget
DB01198ZopicloneCytochrome P450 2C8enzyme
DB01198ZopicloneCytochrome P450 2C9enzyme
DB01198ZopicloneCytochrome P450 3A4enzyme
DB01198ZopicloneProstaglandin G/H synthase 1enzyme
DB01198ZopicloneGamma-aminobutyric acid receptor subunit alpha-1target
DB01198ZopicloneGamma-aminobutyric acid receptor subunit alpha-2target
DB01198ZopicloneGamma-aminobutyric acid receptor subunit alpha-3target
DB01198ZopicloneGamma-aminobutyric acid receptor subunit alpha-5target
DB01198ZopicloneCytochrome P450 2E1enzyme
DB09034SuvorexantOrexin receptor type 1target
DB09034SuvorexantOrexin receptor type 2target
DB09034SuvorexantCytochrome P450 3A4enzyme