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Identification
NameHydroxyzine
Accession NumberDB00557  (APRD00688)
TypeSmall Molecule
GroupsApproved
DescriptionA histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite cetirizine, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative. [PubChem]
Structure
Thumb
Synonyms
Hidroxizina
Hychotine
Hydroksyzyny
Hydroxine
Hydroxizine
Hydroxizinum
Hydroxycine
Hydroxyzin
Hydroxyzine
Hydroxyzinum
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Atarax Cap 10mgCapsule10 mgOralErfa Canada 2012 Inc1956-12-312005-09-15Canada
Atarax Cap 25mgCapsule25 mgOralErfa Canada 2012 Inc1956-12-312005-09-15Canada
Atarax Cap 50mgCapsule50 mgOralErfa Canada 2012 Inc1959-12-312005-09-15Canada
Atarax Im Sol 50mg/mlSolution50 mgIntramuscularErfa Canada 2012 Inc1957-12-312005-08-18Canada
Atarax Syrup 2mg/mlSyrup2 mgOralErfa Canada 2012 Inc1956-12-31Not applicableCanada
Hydroxyzine Hydrochloride InjectionLiquid50 mgIntramuscularFresenius Kabi Canada Ltd2001-04-05Not applicableCanada
Hydroxyzine Hydrochloride Injection USPLiquid50 mgIntramuscularSandoz Canada Incorporated1987-12-31Not applicableCanada
Hydroxyzine Hydrochloride Injection, USPSolution50 mgIntramuscularSterimax Inc1997-05-16Not applicableCanada
Hydroxyzine-10Capsule10 mgOralPro Doc Limitee1987-12-312014-07-24Canada
Hydroxyzine-25Capsule25 mgOralPro Doc Limitee1987-12-312014-07-24Canada
Hydroxyzine-50Capsule50 mgOralPro Doc Limitee1987-12-312014-07-24Canada
Multipax Cap 10mgCapsule10 mgOralRhone Poulenc Rorer Canada Inc.1992-12-311997-08-13Canada
Multipax Cap 25mgCapsule25 mgOralRhone Poulenc Rorer Canada Inc.1992-12-312000-07-28Canada
Novo-hydroxyzinCapsule25 mgOralTeva Canada Limited1987-12-31Not applicableCanada
Novo-hydroxyzinCapsule50 mgOralTeva Canada Limited1987-12-31Not applicableCanada
Novo-hydroxyzinCapsule10 mgOralTeva Canada Limited1987-12-31Not applicableCanada
Nu-hydroxyzineCapsule10 mgOralNu Pharm Inc1995-12-312012-09-04Canada
Nu-hydroxyzineCapsule50 mgOralNu Pharm Inc1995-12-312012-09-04Canada
Nu-hydroxyzineCapsule25 mgOralNu Pharm Inc1995-12-312012-09-04Canada
PMS Hydroxyzine Cap 10mgCapsule10 mgOralPharmascience Inc1988-12-31Not applicableCanada
PMS Hydroxyzine Cap 25mgCapsule25 mgOralPharmascience Inc1988-12-31Not applicableCanada
PMS Hydroxyzine Cap 50mgCapsule50 mgOralPharmascience Inc1988-12-31Not applicableCanada
PMS Hydroxyzine Syr 10mg/5mlSyrup10 mgOralPharmascience Inc1988-12-31Not applicableCanada
Riva-hydroxyzin 10mg CapsulesCapsule10 mgOralLaboratoire Riva Inc1999-11-232013-07-31Canada
Riva-hydroxyzin 25mg CapsulesCapsule25 mgOralLaboratoire Riva Inc1999-11-232013-07-31Canada
Riva-hydroxyzin 50mg CapsulesCapsule50 mgOralLaboratoire Riva Inc1999-11-232013-07-31Canada
VistarilSolution50 mg/mLIntramuscularRoerig1957-09-18Not applicableUs
VistarilCapsule50 mg/1OralREMEDYREPACK INC.2013-03-11Not applicableUs
VistarilCapsule25 mg/1OralPfizer Laboratories Div Pfizer Inc1994-11-28Not applicableUs
VistarilCapsule50 mg/1OralPfizer Laboratories Div Pfizer Inc1968-11-15Not applicableUs
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo Hydroxyzine Cap 10mgCapsule10 mgOralApotex Inc1986-12-31Not applicableCanada
Apo Hydroxyzine Cap 25mgCapsule25 mgOralApotex Inc1986-12-31Not applicableCanada
Apo Hydroxyzine Cap 50mgCapsule50 mgOralApotex Inc1986-12-31Not applicableCanada
Hydoxyzine PamoateCapsule25 mg/1OralPd Rx Pharmaceuticals, Inc.1981-12-14Not applicableUs
HydroxyzineInjection, solution50 mg/mLIntramuscularGeneral Injectables & Vaccines, Inc2010-03-01Not applicableUs
HydroxyzineTablet, film coated10 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2007-03-20Not applicableUs
HydroxyzineSolution10 mg/5mLOralPreferred Pharmaceuticals, Inc.2015-08-21Not applicableUs
HydroxyzineTablet, film coated25 mg/1OralBlenheim Pharmacal, Inc.2010-05-17Not applicableUs
HydroxyzineTablet, film coated10 mg/1OralMajor Pharmaceuticals2007-03-20Not applicableUs
HydroxyzineInjection, solution25 mg/mLIntramuscularGeneral Injectables & Vaccines, Inc2010-03-01Not applicableUs
HydroxyzineTablet, film coated25 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2007-03-20Not applicableUs
HydroxyzineTablet, film coated25 mg/1OralMajor Pharmaceuticals2007-03-20Not applicableUs
HydroxyzineInjection, solution50 mg/mLIntramuscularGeneral Injectables & Vaccines, Inc2010-03-01Not applicableUs
HydroxyzineTablet, film coated50 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2007-03-20Not applicableUs
HydroxyzineTablet, film coated50 mg/1OralMajor Pharmaceuticals2007-03-20Not applicableUs
HydroxyzineTablet, film coated10 mg/1OralBlenheim Pharmacal, Inc.2009-12-28Not applicableUs
HydroxyzineInjection, solution50 mg/mLIntramuscularGeneral Injectables & Vaccines, Inc2010-03-01Not applicableUs
Hydroxyzine HClSolution10 mg/5mLOralSTI Pharma LLC1982-01-01Not applicableUs
Hydroxyzine HClTablet, film coated10 mg/1OralDIRECT RX2016-02-12Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated10 mg/1OralPhysicians Total Care, Inc.1994-07-28Not applicableUs
Hydroxyzine HydrochlorideTablet10 mg/1OralCaraco Pharmaceutical Laboratories, Ltd.2009-03-31Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralBlenheim Pharmacal, Inc.2010-09-15Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralProficient Rx LP2005-05-27Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated50 mg/1OralAmerican Health Packaging2009-01-13Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralMylan Institutional Inc.2010-08-13Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralLife Line Home Care Services, Inc.2012-01-18Not applicableUs
Hydroxyzine HydrochlorideTablet50 mg/1OralProficient Rx LP2012-03-24Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralRed Pharm Drug, Inc.2008-06-30Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated50 mg/1OralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
Hydroxyzine HydrochlorideSolution10 mg/5mLOralKvk Tech, Inc.2008-09-26Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated50 mg/1OralGolden State Medical Supply, Inc.2008-09-24Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralCamber Pharmaceuticals, Inc.2008-05-29Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated10 mg/1OralA S Medication Solutions Llc2012-07-24Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated10 mg/1OralKvk Tech, Inc.2012-07-24Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated50 mg/1OralMylan Pharmaceuticals Inc.2010-07-23Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralA S Medication Solutions2012-07-24Not applicableUs
Hydroxyzine HydrochlorideSyrup10 mg/5mLOralPharmaceutical Associates, Inc.2015-01-01Not applicableUs
Hydroxyzine HydrochlorideTablet10 mg/1OralNorthstar Rx LLC2009-11-11Not applicableUs
Hydroxyzine HydrochlorideSyrup10 mg/5mLOralA S Medication Solutions1995-03-09Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated10 mg/1OralNu Care Pharmaceuticals, Inc.2008-06-30Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralClinical Solutions Wholesale2012-07-24Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralWatson Laboratories, Inc.2011-11-212016-02-11Us
Hydroxyzine HydrochlorideSyrup10 mg/5mLOralPhysicians Total Care, Inc.2000-09-13Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralProficient Rx LP2008-06-30Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated10 mg/1OralEpic Pharma, LLC2015-03-31Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralDispensing Solutions, Inc.2005-05-27Not applicableUs
Hydroxyzine HydrochlorideTablet25 mg/1OralREMEDYREPACK INC.2011-05-162016-12-07Us
Hydroxyzine HydrochlorideTablet, film coated50 mg/1OralGlenmark Generics Inc., USA2008-03-012016-09-01Us
Hydroxyzine HydrochlorideTablet, film coated50 mg/1OralREMEDYREPACK INC.2013-06-04Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralTeva Pharmaceuticals Usa, Inc.2012-10-09Not applicableUs
Hydroxyzine HydrochlorideTablet25 mg/1OralHeritage Pharmaceuticals Inc.2012-03-24Not applicableUs
Hydroxyzine HydrochlorideInjection, solution50 mg/mLIntramuscularAmerican Regent, Inc.1990-09-30Not applicableUs
Hydroxyzine HydrochlorideTablet50 mg/1OralREMEDYREPACK INC.2015-12-14Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated50 mg/1OralGlenmark Pharmaceuticals Inc., Usa2015-02-01Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralH.J. Harkins Company, Inc.2008-06-30Not applicableUs
Hydroxyzine HydrochlorideSyrup10 mg/5mLOralA S Medication Solutions Llc1995-03-09Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralPd Rx Pharmaceuticals, Inc.2010-12-07Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralRebel Distributors Corp2008-06-30Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralDIRECT RX2015-01-01Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralPd Rx Pharmaceuticals, Inc.2012-07-24Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralHarris Pharmaceutical, Inc.2007-06-29Not applicableUs
Hydroxyzine HydrochlorideSolution10 mg/5mLOralPreferred Pharmaceuticals, Inc.2015-01-13Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated50 mg/1OralPhysicians Total Care, Inc.1993-09-21Not applicableUs
Hydroxyzine HydrochlorideTablet25 mg/1OralCaraco Pharmaceutical Laboratories, Ltd.2009-03-31Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated10 mg/1OralBlenheim Pharmacal, Inc.2011-04-18Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated10 mg/1OralHeritage Pharmaceuticals Inc.2008-06-30Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralProficient Rx LP2007-06-29Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated50 mg/1OralMylan Institutional Inc.2010-08-13Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralMc Kesson Contract Packaging2012-01-23Not applicableUs
Hydroxyzine HydrochlorideInjection, solution25 mg/mLIntramuscularFresenius Kabi USA, LLC2000-10-17Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated10 mg/1OralQualitest Pharmaceuticals2005-05-272016-12-31Us
Hydroxyzine HydrochlorideTablet25 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2012-03-24Not applicableUs
Hydroxyzine HydrochlorideTablet25 mg/1OralProficient Rx LP2012-03-24Not applicableUs
Hydroxyzine HydrochlorideTablet50 mg/1OralAidarex Pharmaceuticals LLC2012-03-24Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralKAISER FOUNDATION HOSPITALS2010-10-08Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated10 mg/1OralA S Medication Solutions Llc2005-05-27Not applicableUs
Hydroxyzine HydrochlorideInjection, solution50 mg/mLIntramuscularCardinal Health1990-09-30Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated50 mg/1OralCamber Pharmaceuticals, Inc.2008-05-29Not applicableUs
Hydroxyzine HydrochlorideTablet10 mg/1OralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2011-03-01Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralRed Pharm Drug Inc.2009-08-07Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated50 mg/1OralA S Medication Solutions Llc2005-05-27Not applicableUs
Hydroxyzine HydrochlorideSolution10 mg/5mLOralPreferred Pharmaceuticals, Inc.2014-02-06Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralKvk Tech, Inc.2012-07-24Not applicableUs
Hydroxyzine HydrochlorideInjection, solution25 mg/mLIntramuscularAmerican Regent, Inc.1990-09-30Not applicableUs
Hydroxyzine HydrochlorideSyrup10 mg/5mLOralMorton Grove Pharmaceuticals, Inc.1995-03-09Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralUnit Dose Services2008-06-30Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated50 mg/1OralREMEDYREPACK INC.2013-05-282016-04-05Us
Hydroxyzine HydrochlorideTablet, film coated50 mg/1OralTeva Pharmaceuticals Usa, Inc.2012-10-22Not applicableUs
Hydroxyzine HydrochlorideTablet25 mg/1OralNorthstar Rx LLC2009-11-11Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated50 mg/1OralClinical Solutions Wholesale2012-07-24Not applicableUs
Hydroxyzine HydrochlorideSolution10 mg/5mLOralQualitest Pharmaceuticals2002-04-102016-10-13Us
Hydroxyzine HydrochlorideTablet, film coated50 mg/1OralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralCardinal Health2009-01-13Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralBlenheim Pharmacal, Inc.2013-11-18Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralEpic Pharma, LLC2015-03-31Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-11-21Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated50 mg/1OralPd Rx Pharmaceuticals, Inc.2012-07-24Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated10 mg/1OralAmerican Health Packaging2009-01-13Not applicableUs
Hydroxyzine HydrochlorideTablet50 mg/1OralHeritage Pharmaceuticals Inc.2012-03-24Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated10 mg/1OralPreferred Pharmaceuticals, Inc.2015-04-15Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralCardinal Health2010-07-23Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated50 mg/1OralRebel Distributors Corp2008-06-30Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated50 mg/1OralLake Erie Medical DBA Quality Care Products LLC2012-07-24Not applicableUs
Hydroxyzine HydrochlorideTablet25 mg/1OralREMEDYREPACK INC.2011-05-232017-11-17Us
Hydroxyzine HydrochlorideTablet, film coated50 mg/1OralWatson Laboratories, Inc.2011-11-212016-02-11Us
Hydroxyzine HydrochlorideSolution10 mg/5mLOralPhysicians Total Care, Inc.1994-08-01Not applicableUs
Hydroxyzine HydrochlorideTablet50 mg/1OralCaraco Pharmaceutical Laboratories, Ltd.2009-03-31Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated10 mg/1OralBlenheim Pharmacal, Inc.2012-11-16Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralHeritage Pharmaceuticals Inc.2008-06-30Not applicableUs
Hydroxyzine HydrochlorideSyrup10 mg/5mLOralProficient Rx LP1995-03-09Not applicableUs
Hydroxyzine HydrochlorideCapsule50 mg/1OralREMEDYREPACK INC.2011-08-122016-11-08Us
Hydroxyzine HydrochlorideTablet, film coated10 mg/1OralGlenmark Generics Inc., USA2008-03-012016-09-01Us
Hydroxyzine HydrochlorideTablet10 mg/1OralNorthwind Pharmaceuticals, LLC2014-09-15Not applicableUs
Hydroxyzine HydrochlorideInjection, solution50 mg/mLIntramuscularFresenius Kabi USA, LLC2000-08-08Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralQualitest Pharmaceuticals2005-05-272017-03-31Us
Hydroxyzine HydrochlorideSyrup10 mg/5mLOralAtlantic Biologicals Corps1995-03-09Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated10 mg/1OralGlenmark Pharmaceuticals Inc., Usa2015-02-01Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated10 mg/1OralKAISER FOUNDATION HOSPITALS2010-10-08Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated50 mg/1OralA S Medication Solutions Llc2005-05-27Not applicableUs
Hydroxyzine HydrochlorideInjection, solution25 mg/mLIntramuscularCardinal Health1990-09-30Not applicableUs
Hydroxyzine HydrochlorideTablet25 mg/1OralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2011-03-01Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated50 mg/1OralPd Rx Pharmaceuticals, Inc.2007-06-29Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated10 mg/1OralHarris Pharmaceutical, Inc.2007-06-29Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralA S Medication Solutions Llc2005-05-27Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated50 mg/1OralKvk Tech, Inc.2012-07-24Not applicableUs
Hydroxyzine HydrochlorideInjection, solution50 mg/mLIntramuscularAmerican Regent, Inc.1990-09-30Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated50 mg/1OralEpic Pharma, LLC2015-03-31Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated50 mg/1OralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-11-28Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated50 mg/1OralREMEDYREPACK INC.2014-01-30Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralREMEDYREPACK INC.2016-02-11Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated10 mg/1OralMylan Pharmaceuticals Inc.2010-07-23Not applicableUs
Hydroxyzine HydrochlorideTablet50 mg/1OralNorthstar Rx LLC2009-11-11Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated50 mg/1OralA S Medication Solutions2012-07-24Not applicableUs
Hydroxyzine HydrochlorideTablet25 mg/1OralREMEDYREPACK INC.2011-03-302017-11-22Us
Hydroxyzine HydrochlorideTablet, film coated50 mg/1OralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated10 mg/1OralGolden State Medical Supply, Inc.2008-09-24Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated50 mg/1OralBlenheim Pharmacal, Inc.2013-11-18Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated10 mg/1Oralbryant ranch prepack2008-06-30Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated10 mg/1OralRebel Distributors Corp2008-06-30Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralLake Erie Medical DBA Quality Care Products LLC2012-07-24Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralPd Rx Pharmaceuticals, Inc.2012-07-24Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralAmerican Health Packaging2009-01-13Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated10 mg/1OralMylan Institutional Inc.2010-08-13Not applicableUs
Hydroxyzine HydrochlorideSolution10 mg/5mLOralHi Tech Pharmacal Co., Inc.1994-10-28Not applicableUs
Hydroxyzine HydrochlorideTablet25 mg/1OralREMEDYREPACK INC.2016-05-19Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated10 mg/1OralPd Rx Pharmaceuticals, Inc.2007-06-29Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralLiberty Pharmaceuticals, Inc.2012-07-24Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated50 mg/1OralAidarex Pharmaceuticals LLC2012-07-24Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralPhysicians Total Care, Inc.1994-04-04Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated10 mg/1OralNu Care Pharmaceuticals, Inc.2008-06-30Not applicableUs
Hydroxyzine HydrochlorideSolution10 mg/5mLOralSilarx Pharmaceuticals, Inc.2013-08-21Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated10 mg/1OralWatson Laboratories, Inc.2011-11-212016-02-11Us
Hydroxyzine HydrochlorideTablet, film coated50 mg/1OralHeritage Pharmaceuticals Inc.2008-06-30Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated50 mg/1OralProficient Rx LP2008-06-30Not applicableUs
Hydroxyzine HydrochlorideTablet50 mg/1OralREMEDYREPACK INC.2011-03-112016-11-23Us
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralGlenmark Generics Inc., USA2008-03-012016-09-01Us
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralNorthwind Pharmaceuticals, LLC2015-02-26Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated10 mg/1OralTeva Pharmaceuticals Usa, Inc.2013-02-19Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated50 mg/1OralQualitest Pharmaceuticals2005-05-272016-12-31Us
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralGlenmark Pharmaceuticals Inc., Usa2015-02-01Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralA S Medication Solutions Llc2005-05-27Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated50 mg/1OralPd Rx Pharmaceuticals, Inc.2005-05-27Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated50 mg/1OralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2008-06-30Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated10 mg/1OralPd Rx Pharmaceuticals, Inc.2012-07-24Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated50 mg/1OralHarris Pharmaceutical, Inc.2007-06-29Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralA S Medication Solutions Llc2005-05-27Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated10 mg/1OralPreferred Pharmaceuticals, Inc.2012-10-08Not applicableUs
Hydroxyzine HydrochlorideTablet10 mg/1OralHeritage Pharmaceuticals Inc.2012-03-24Not applicableUs
Hydroxyzine HydrochlorideInjection, solution50 mg/mLIntramuscularAmerican Regent, Inc.1990-09-30Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralGolden State Medical Supply, Inc.2012-08-22Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated10 mg/1OralCamber Pharmaceuticals, Inc.2008-05-29Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated50 mg/1Oralbryant ranch prepack2008-06-30Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralPd Rx Pharmaceuticals, Inc.2007-06-29Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralRed Pharm Drug Inc.2010-12-07Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralREMEDYREPACK INC.2014-03-03Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralMylan Pharmaceuticals Inc.2010-07-23Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated25 mg/1OralA S Medication Solutions2008-06-30Not applicableUs
Hydroxyzine HydrochlorideTablet, film coated50 mg/1OralA S Medication Solutions2015-02-01Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralRebel Distributors Corp1996-07-15Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralAv Kare, Inc.2013-03-07Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralTYA Pharmaceuticals1996-07-15Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralAphena Pharma Solutions Tennessee, Llc1996-07-15Not applicableUs
Hydroxyzine PamoateCapsule50 mg/1OralA S Medication Solutions1981-12-14Not applicableUs
Hydroxyzine PamoateCapsule100 mg/1OralTeva Pharmaceuticals Usa, Inc.1984-07-01Not applicableUs
Hydroxyzine PamoateCapsule50 mg/1OralImpax Generics1996-06-15Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralWatson Laboratories, Inc.1996-07-15Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralCardinal Health2012-09-25Not applicableUs
Hydroxyzine PamoateCapsule50 mg/1Oralbryant ranch prepack1996-07-15Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralRed Pharm Drug Inc.2010-07-01Not applicableUs
Hydroxyzine PamoateCapsule50 mg/1OralA S Medication Solutions1996-06-15Not applicableUs
Hydroxyzine PamoateCapsule100 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralClinical Solutions Wholsesale1981-12-14Not applicableUs
Hydroxyzine PamoateCapsule50 mg/1OralREMEDYREPACK INC.2013-03-192016-11-22Us
Hydroxyzine PamoateCapsule50 mg/1OralREMEDYREPACK INC.2016-05-18Not applicableUs
Hydroxyzine PamoateCapsule50 mg/1OralEon Labs, Inc.1981-12-14Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralLake Erie Medical DBA Quality Care Products LLC1984-07-01Not applicableUs
Hydroxyzine PamoateCapsule50 mg/1OralTYA Pharmaceuticals2010-11-17Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralMylan Institutional Inc.2007-11-26Not applicableUs
Hydroxyzine PamoateCapsule50 mg/1OralWatson Laboratories, Inc.1996-06-15Not applicableUs
Hydroxyzine PamoateCapsule50 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Hydroxyzine PamoateCapsule50 mg/1OralAv Kare, Inc.2013-03-07Not applicableUs
Hydroxyzine PamoateCapsule50 mg/1OralTYA Pharmaceuticals1996-06-15Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralREMEDYREPACK INC.2011-08-032016-11-02Us
Hydroxyzine PamoateCapsule25 mg/1OralAmerican Health Packaging2015-02-15Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralDIRECT RX2014-01-01Not applicableUs
Hydroxyzine PamoateCapsule50 mg/1OralApotheca Inc.1981-12-14Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralGolden State Medical Supply, Inc.2014-05-20Not applicableUs
Hydroxyzine PamoateCapsule100 mg/1OralPd Rx Pharmaceuticals, Inc.2011-09-01Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralA S Medication Solutions2014-06-27Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralNu Care Pharmaceuticals, Inc.2010-11-17Not applicableUs
Hydroxyzine PamoateCapsule50 mg/1OralClinical Solutions Wholsesale1981-12-14Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralREMEDYREPACK INC.2013-04-082016-10-22Us
Hydroxyzine PamoateCapsule25 mg/1Oralbryant ranch prepack1996-07-15Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralContract Pharmacy Services Pa2010-08-16Not applicableUs
Hydroxyzine PamoateCapsule50 mg/1OralPreferred Pharmaceuticals, Inc.2004-07-21Not applicableUs
Hydroxyzine PamoateCapsule50 mg/1OralMylan Institutional Inc.2007-11-26Not applicableUs
Hydroxyzine PamoateCapsule50 mg/1OralAvera Mc Kennan Hospital2015-03-04Not applicableUs
Hydroxyzine PamoateCapsule50 mg/1OralTeva Pharmaceuticals Usa, Inc.1984-07-01Not applicableUs
Hydroxyzine PamoateCapsule50 mg/1OralREMEDYREPACK INC.2016-05-16Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralEon Labs, Inc.2014-06-27Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralH.J. Harkins Company, Inc.2010-07-01Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralA S Medication Solutions Llc1981-12-142016-04-05Us
Hydroxyzine PamoateCapsule25 mg/1OralPd Rx Pharmaceuticals, Inc.1996-07-15Not applicableUs
Hydroxyzine PamoateCapsule50 mg/1OralAmerican Health Packaging2013-06-12Not applicableUs
Hydroxyzine PamoateCapsule50 mg/1OralTYA Pharmaceuticals1984-07-01Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Hydroxyzine PamoateCapsule50 mg/1OralWestwood Manufacturing2010-11-17Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralRising Pharmaceuticals Inc.2010-11-17Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralAmerican Health Packaging2013-06-122015-11-30Us
Hydroxyzine PamoateCapsule25 mg/1OralTYA Pharmaceuticals2010-11-17Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralSTAT Rx USA LLC1981-12-14Not applicableUs
Hydroxyzine PamoateCapsule50 mg/1OralGolden State Medical Supply, Inc.2014-05-20Not applicableUs
Hydroxyzine PamoateCapsule50 mg/1OralAidarex Pharmaceuticals LLC1981-12-14Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralPreferred Pharmaceuticals, Inc.2013-04-22Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralREMEDYREPACK INC.2015-01-16Not applicableUs
Hydroxyzine PamoateCapsule50 mg/1OralREMEDYREPACK INC.2014-06-19Not applicableUs
Hydroxyzine PamoateCapsule50 mg/1OralContract Pharmacy Services Pa2010-08-16Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralPreferred Pharmaceuticals, Inc.2004-07-21Not applicableUs
Hydroxyzine PamoateCapsule50 mg/1OralA S Medication Solutions1981-12-14Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs1981-12-14Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralCardinal Health2013-06-12Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralREMEDYREPACK INC.2013-06-24Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralProficient Rx LP1996-07-15Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralTYA Pharmaceuticals1984-07-01Not applicableUs
Hydroxyzine PamoateCapsule50 mg/1OralAvera Mc Kennan Hospital2015-03-01Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralTeva Pharmaceuticals Usa, Inc.1984-07-01Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralImpax Generics1996-07-15Not applicableUs
Hydroxyzine PamoateCapsule50 mg/1OralPd Rx Pharmaceuticals, Inc.1981-12-14Not applicableUs
Hydroxyzine PamoateCapsule50 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralPhysicians Total Care, Inc.2000-02-09Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralClinical Solutions Wholsesale1981-12-14Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralSTAT Rx USA LLC1996-07-15Not applicableUs
Hydroxyzine PamoateCapsule50 mg/1OralRising Pharmaceuticals Inc.2010-11-17Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralAphena Pharma Solutions Tennessee, Llc2014-05-20Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralREMEDYREPACK INC.2015-03-05Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralREMEDYREPACK INC.2014-08-21Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralEon Labs, Inc.1981-12-14Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2014-06-27Not applicableUs
Hydroxyzine PamoateCapsule50 mg/1OralSTAT Rx USA LLC1996-06-15Not applicableUs
Hydroxyzine PamoateCapsule50 mg/1OralREMEDYREPACK INC.2015-10-20Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralTYA Pharmaceuticals2010-11-17Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralBlenheim Pharmacal, Inc.2013-11-11Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC1996-07-15Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralPreferred Pharmaceuticals, Inc.2014-07-23Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralPd Rx Pharmaceuticals, Inc.1981-12-14Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralProficient Rx LP2010-11-17Not applicableUs
Hydroxyzine PamoateCapsule50 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs1981-12-14Not applicableUs
Hydroxyzine PamoateCapsule25 mg/1OralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
Hydroxyzine PamoateCapsule50 mg/1OralCardinal Health2011-08-03Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
AtaraxUCB
HyzineHyrex
MasmoranPfizer
RezineNot Available
Vistaject-50Not Available
VistazineNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Hydroxyzine hydrochloride
2192-20-3
Thumb
  • InChI Key: ANOMHKZSQFYSBR-UHFFFAOYNA-N
  • Monoisotopic Mass: 446.129461303
  • Average Mass: 447.826
DBSALT000343
Hydroxyzine pamoate
10246-75-0
Thumb
  • InChI Key: ASDOKGIIKXGMNB-UHFFFAOYSA-N
  • Monoisotopic Mass: 762.2707941
  • Average Mass: 763.28
DBSALT000984
Categories
UNII30S50YM8OG
CAS number68-88-2
WeightAverage: 374.904
Monoisotopic: 374.176105825
Chemical FormulaC21H27ClN2O2
InChI KeyZQDWXGKKHFNSQK-UHFFFAOYSA-N
InChI
InChI=1S/C21H27ClN2O2/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25/h1-9,21,25H,10-17H2
IUPAC Name
2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)ethan-1-ol
SMILES
OCCOCCN1CCN(CC1)C(C1=CC=CC=C1)C1=CC=C(Cl)C=C1
Pharmacology
IndicationFor symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria.
Structured Indications
PharmacodynamicsHydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Hydroxyzine is also used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Hydroxyzine's active metabolite, cetirizine, is also used as an H1-antagonist.
Mechanism of actionHydroxyzine competes with histamine for binding at H1-receptor sites on the effector cell surface, resulting in suppression of histaminic edema, flare, and pruritus. The sedative properties of hydroxyzine occur at the subcortical level of the CNS. Secondary to its central anticholinergic actions, hydroxyzine may be effective as an antiemetic.
TargetKindPharmacological actionActionsOrganismUniProt ID
Histamine H1 receptorProteinyes
antagonist
HumanP35367 details
Related Articles
AbsorptionRapidly absorbed from the gastrointestinal tract
Volume of distributionNot Available
Protein binding93%
Metabolism

Hepatic

Route of eliminationNot Available
Half life20 to 25 hours
ClearanceNot Available
ToxicityOral, rat LD50: 950 mg/kg. Symptoms of overexposure include hypersedation.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
1,1,1,2 TetrafluoroethaneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of 1,1,1,2 Tetrafluoroethane.Investigational
2,5-Dimethoxy-4-ethylamphetamine2,5-Dimethoxy-4-ethylamphetamine may decrease the sedative activities of Hydroxyzine.Experimental, Illicit
3,4-Methylenedioxyamphetamine3,4-Methylenedioxyamphetamine may decrease the sedative activities of Hydroxyzine.Experimental, Illicit
3,4-Methylenedioxymethamphetamine3,4-Methylenedioxymethamphetamine may decrease the sedative activities of Hydroxyzine.Experimental, Illicit
4-Bromo-2,5-dimethoxyamphetamine4-Bromo-2,5-dimethoxyamphetamine may decrease the sedative activities of Hydroxyzine.Experimental, Illicit
7-NitroindazoleHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of 7-Nitroindazole.Experimental
AcepromazineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Acepromazine.Approved, Vet Approved
AceprometazineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Aceprometazine.Approved
adipiplonHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of adipiplon.Investigational
AgomelatineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Agomelatine.Approved, Investigational
AlfaxaloneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Alfaxalone.Vet Approved
AlfentanilHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Alfentanil.Approved, Illicit
AlphacetylmethadolHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Alphacetylmethadol.Experimental, Illicit
AlprazolamHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Alprazolam.Approved, Illicit, Investigational
AmiodaroneHydroxyzine may increase the QTc-prolonging activities of Amiodarone.Approved, Investigational
AmisulprideHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Amisulpride.Approved, Investigational
AmitriptylineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.Approved
AmobarbitalHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Amobarbital.Approved, Illicit
AmoxapineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Amoxapine.Approved
AmperozideHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Amperozide.Experimental
AmphetamineAmphetamine may decrease the sedative activities of Hydroxyzine.Approved, Illicit
AnagrelideHydroxyzine may increase the QTc-prolonging activities of Anagrelide.Approved
AripiprazoleHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Aripiprazole.Approved, Investigational
Arsenic trioxideHydroxyzine may increase the QTc-prolonging activities of Arsenic trioxide.Approved, Investigational
ArtemetherHydroxyzine may increase the QTc-prolonging activities of Artemether.Approved
ArticaineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Articaine.Approved
AsenapineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Asenapine.Approved
AzaperoneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Azaperone.Vet Approved
AzelastineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
AzithromycinHydroxyzine may increase the QTc-prolonging activities of Azithromycin.Approved
BaclofenHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Baclofen.Approved
BarbexacloneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Barbexaclone.Experimental
BarbitalHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Barbital.Illicit
BedaquilineHydroxyzine may increase the QTc-prolonging activities of Bedaquiline.Approved
BenperidolHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Benperidol.Investigational
BenzocaineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Benzocaine.Approved
BenzphetamineBenzphetamine may decrease the sedative activities of Hydroxyzine.Approved, Illicit
Benzyl alcoholHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Benzyl alcohol.Approved
Benzylpenicilloyl PolylysineHydroxyzine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.Approved
BetahistineThe therapeutic efficacy of Betahistine can be decreased when used in combination with Hydroxyzine.Approved
BrexpiprazoleHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Brexpiprazole.Approved
BrimonidineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Brimonidine.Approved
BromazepamHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Bromazepam.Approved, Illicit
BrompheniramineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Brompheniramine.Approved
BrotizolamHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Brotizolam.Approved, Withdrawn
BupivacaineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Bupivacaine.Approved, Investigational
BuprenorphineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Buspirone.Approved, Investigational
ButabarbitalHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Butabarbital.Approved, Illicit
ButacaineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Butacaine.Vet Approved
ButalbitalHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Butalbital.Approved, Illicit
ButambenHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Butamben.Approved
ButethalHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Butethal.Approved, Illicit
ButorphanolHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Butorphanol.Approved, Illicit, Vet Approved
CarbamazepineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Carbamazepine.Approved, Investigational
CarbinoxamineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Carbinoxamine.Approved
CarfentanilHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Carfentanil.Illicit, Vet Approved
CarisoprodolHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Carisoprodol.Approved
CeritinibHydroxyzine may increase the QTc-prolonging activities of Ceritinib.Approved
CetirizineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Cetirizine.Approved
Chloral hydrateHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.Approved, Illicit, Vet Approved
ChlordiazepoxideHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.Approved, Illicit
ChlormezanoneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Chlormezanone.Approved, Withdrawn
ChloroprocaineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Chloroprocaine.Approved
ChloroquineHydroxyzine may increase the QTc-prolonging activities of Chloroquine.Approved, Vet Approved
ChlorphenamineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.Approved
ChlorphentermineChlorphentermine may decrease the sedative activities of Hydroxyzine.Illicit, Withdrawn
ChlorpromazineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Chlorpromazine.Approved, Vet Approved
ChlorprothixeneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Chlorprothixene.Approved, Withdrawn
ChlorzoxazoneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Chlorzoxazone.Approved
CinchocaineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Cinchocaine.Approved, Vet Approved
CiprofloxacinHydroxyzine may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
CisaprideHydroxyzine may increase the QTc-prolonging activities of Cisapride.Approved, Investigational, Withdrawn
CitalopramHydroxyzine may increase the QTc-prolonging activities of Citalopram.Approved
ClarithromycinHydroxyzine may increase the QTc-prolonging activities of Clarithromycin.Approved
ClemastineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Clemastine.Approved
ClidiniumHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Clidinium.Approved
ClobazamHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Clobazam.Approved, Illicit
clomethiazoleHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of clomethiazole.Investigational
ClomipramineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Clomipramine.Approved, Vet Approved
ClonazepamHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Clonazepam.Approved, Illicit
ClonidineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Clonidine.Approved
ClorazepateHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Clorazepate.Approved, Illicit
ClozapineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Clozapine.Approved
CocaineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Cocaine.Approved, Illicit
CodeineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Codeine.Approved, Illicit
CrizotinibHydroxyzine may increase the QTc-prolonging activities of Crizotinib.Approved
CyclizineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Cyclizine.Approved
CyclobenzaprineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Cyclobenzaprine.Approved
CyproheptadineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Cyproheptadine.Approved
DantroleneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Dantrolene.Approved
DapiprazoleHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Dapiprazole.Approved
DapoxetineThe risk or severity of adverse effects can be increased when Hydroxyzine is combined with Dapoxetine.Investigational
deramciclaneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of deramciclane.Investigational
DesfluraneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Desflurane.Approved
DesipramineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Desipramine.Approved
DesloratadineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Desloratadine.Approved, Investigational
DesvenlafaxineThe risk or severity of adverse effects can be increased when Hydroxyzine is combined with Desvenlafaxine.Approved
DetomidineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Detomidine.Vet Approved
DexbrompheniramineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Dexbrompheniramine.Approved
DexmedetomidineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Dexmedetomidine.Approved, Vet Approved
DextroamphetamineDextroamphetamine may decrease the sedative activities of Hydroxyzine.Approved, Illicit
DextromoramideHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Dextromoramide.Experimental, Illicit
DextropropoxypheneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Dextropropoxyphene.Approved, Illicit, Withdrawn
DezocineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Dezocine.Approved
DiazepamHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Diazepam.Approved, Illicit, Vet Approved
DiethylpropionDiethylpropion may decrease the sedative activities of Hydroxyzine.Approved, Illicit
DifenoxinHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Difenoxin.Approved, Illicit
DihydrocodeineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Dihydrocodeine.Approved, Illicit
DihydroetorphineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Dihydroetorphine.Experimental, Illicit
DihydromorphineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Dihydromorphine.Experimental, Illicit
DimenhydrinateHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Dimenhydrinate.Approved
DiphenhydramineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Diphenhydramine.Approved
DiphenoxylateHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Diphenoxylate.Approved, Illicit
DisopyramideHydroxyzine may increase the QTc-prolonging activities of Disopyramide.Approved
DofetilideHydroxyzine may increase the QTc-prolonging activities of Dofetilide.Approved
DolasetronHydroxyzine may increase the QTc-prolonging activities of Dolasetron.Approved
DomperidoneHydroxyzine may increase the QTc-prolonging activities of Domperidone.Approved, Investigational, Vet Approved
DoramectinHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Doramectin.Vet Approved
DoxepinHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.Approved
DoxylamineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.Approved, Vet Approved
DPDPEHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of DPDPE.Investigational
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Hydroxyzine.Approved, Illicit
DronedaroneHydroxyzine may increase the QTc-prolonging activities of Dronedarone.Approved
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Hydroxyzine.Approved, Vet Approved
DrotebanolHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Drotebanol.Experimental, Illicit
DuloxetineThe risk or severity of adverse effects can be increased when Hydroxyzine is combined with Duloxetine.Approved
DyclonineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Dyclonine.Approved
EcgonineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Ecgonine.Experimental, Illicit
ECGONINE METHYL ESTERHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of ECGONINE METHYL ESTER.Experimental
EcopipamHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Ecopipam.Investigational
EfavirenzHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Efavirenz.Approved, Investigational
EliglustatHydroxyzine may increase the QTc-prolonging activities of Eliglustat.Approved
EnfluraneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Enflurane.Approved, Vet Approved
EntacaponeHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Entacapone.Approved, Investigational
ErythromycinHydroxyzine may increase the QTc-prolonging activities of Erythromycin.Approved, Vet Approved
EscitalopramHydroxyzine may increase the QTc-prolonging activities of Escitalopram.Approved, Investigational
EstazolamHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Estazolam.Approved, Illicit
EszopicloneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Eszopiclone.Approved
EthanolHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Ethchlorvynol.Approved, Illicit, Withdrawn
EthosuximideHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Ethosuximide.Approved
EthotoinHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Ethotoin.Approved
Ethyl carbamateHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Ethyl carbamate.Withdrawn
Ethyl loflazepateHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Ethyl loflazepate.Approved, Illicit
EthylmorphineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Ethylmorphine.Approved, Illicit
EtidocaineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Etidocaine.Approved
EtifoxineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Etifoxine.Withdrawn
EtizolamHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Etizolam.Approved
EtomidateHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Etomidate.Approved
EtoperidoneThe risk or severity of adverse effects can be increased when Hydroxyzine is combined with Etoperidone.Approved
EtorphineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Etorphine.Illicit, Vet Approved
EzogabineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Ezogabine.Approved
FelbamateHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Felbamate.Approved
FencamfamineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Fencamfamine.Approved, Illicit, Withdrawn
FentanylHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Fentanyl.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Hydroxyzine.Approved
FexofenadineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.Approved
FlecainideHydroxyzine may increase the QTc-prolonging activities of Flecainide.Approved, Withdrawn
FlibanserinHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Flibanserin.Approved
FludiazepamHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Fludiazepam.Approved, Illicit
FlunarizineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Flunarizine.Approved
FlunitrazepamHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Flunitrazepam.Approved, Illicit
FluoxetineHydroxyzine may increase the QTc-prolonging activities of Fluoxetine.Approved, Vet Approved
FlupentixolHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Flupentixol.Approved, Withdrawn
FluphenazineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Fluphenazine.Approved
FlurazepamHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Flurazepam.Approved, Illicit
FluspirileneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Fluspirilene.Approved
Fluticasone PropionateHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Fluticasone Propionate.Approved
FluvoxamineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Fluvoxamine.Approved, Investigational
FosphenytoinHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Fosphenytoin.Approved
FospropofolHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Fospropofol.Approved, Illicit
GabapentinHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Gabapentin.Approved, Investigational
gabapentin enacarbilHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of gabapentin enacarbil.Approved
Gadobenic acidHydroxyzine may increase the QTc-prolonging activities of Gadobenic acid.Approved
Gamma Hydroxybutyric AcidHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Gamma Hydroxybutyric Acid.Approved, Illicit
GemifloxacinHydroxyzine may increase the QTc-prolonging activities of Gemifloxacin.Approved, Investigational
GepironeHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Gepirone.Investigational
GlutethimideHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.Approved, Illicit
GoserelinHydroxyzine may increase the QTc-prolonging activities of Goserelin.Approved
GranisetronHydroxyzine may increase the QTc-prolonging activities of Granisetron.Approved, Investigational
GuanfacineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Guanfacine.Approved, Investigational
HalazepamHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Halazepam.Approved, Illicit, Withdrawn
HaloperidolHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Haloperidol.Approved
HalothaneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Halothane.Approved, Vet Approved
HeroinHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Heroin.Approved, Illicit
HexobarbitalHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Hexobarbital.Approved
HyaluronidaseThe therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Hydroxyzine.Approved, Investigational
HydrocodoneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydromorphoneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Hydromorphone.Approved, Illicit
Hydroxyamphetamine hydrobromideHydroxyamphetamine hydrobromide may decrease the sedative activities of Hydroxyzine.Approved
IbutilideHydroxyzine may increase the QTc-prolonging activities of Ibutilide.Approved
IloperidoneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Iloperidone.Approved
ImipramineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Imipramine.Approved
IndalpineThe risk or severity of adverse effects can be increased when Hydroxyzine is combined with Indalpine.Investigational, Withdrawn
IsofluraneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Isoflurane.Approved, Vet Approved
KetamineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Ketamine.Approved, Vet Approved
KetazolamHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Ketazolam.Approved
KetobemidoneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Ketobemidone.Approved
LamotrigineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Lamotrigine.Approved, Investigational
LenvatinibHydroxyzine may increase the QTc-prolonging activities of Lenvatinib.Approved
LeuprolideHydroxyzine may increase the QTc-prolonging activities of Leuprolide.Approved, Investigational
LevetiracetamHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Levetiracetam.Approved, Investigational
LevobupivacaineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Levobupivacaine.Approved
LevocabastineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Levocabastine.Approved
LevocetirizineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Levocetirizine.Approved
LevodopaHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Levodopa.Approved
LevofloxacinHydroxyzine may increase the QTc-prolonging activities of Levofloxacin.Approved, Investigational
Levomethadyl AcetateHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Levomethadyl Acetate.Approved
LevomilnacipranThe risk or severity of adverse effects can be increased when Hydroxyzine is combined with Levomilnacipran.Approved
LevorphanolHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Levorphanol.Approved
LidocaineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Lidocaine.Approved, Vet Approved
LisdexamfetamineLisdexamfetamine may decrease the sedative activities of Hydroxyzine.Approved, Investigational
LithiumHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Lithium.Approved
LofentanilHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Lofentanil.Illicit
LopinavirHydroxyzine may increase the QTc-prolonging activities of Lopinavir.Approved
LoratadineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Loratadine.Approved
LorazepamHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Lorazepam.Approved
LoxapineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Loxapine.Approved
Lu AA21004Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Lu AA21004.Investigational
LumefantrineHydroxyzine may increase the QTc-prolonging activities of Lumefantrine.Approved
LurasidoneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Lurasidone.Approved
Magnesium SulfateHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Magnesium Sulfate.Approved, Vet Approved
MaprotilineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Maprotiline.Approved
MeclizineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Meclizine.Approved
MedetomidineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Medetomidine.Vet Approved
MelatoninHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Melatonin.Approved, Nutraceutical, Vet Approved
MelperoneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Melperone.Approved
MephedroneMephedrone may decrease the sedative activities of Hydroxyzine.Investigational
MephentermineMephentermine may decrease the sedative activities of Hydroxyzine.Approved
MepivacaineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Mepivacaine.Approved, Vet Approved
MeprobamateHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Meprobamate.Approved, Illicit
MesoridazineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Mesoridazine.Approved
MetaxaloneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Metaxalone.Approved
MethadoneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Methadone.Approved
Methadyl AcetateHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Methadyl Acetate.Approved, Illicit
MethamphetamineMethamphetamine may decrease the sedative activities of Hydroxyzine.Approved, Illicit
MethapyrileneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Methapyrilene.Withdrawn
MethaqualoneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Methaqualone.Illicit, Withdrawn
MethocarbamolHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Methocarbamol.Approved, Vet Approved
MethohexitalHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Methohexital.Approved
MethotrimeprazineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxyfluraneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Methoxyflurane.Approved, Vet Approved
MethsuximideHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Methsuximide.Approved
MethylphenobarbitalHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Methylphenobarbital.Approved
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Hydroxyzine.Approved, Investigational
MetyrosineHydroxyzine may increase the sedative activities of Metyrosine.Approved
MidazolamHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Midazolam.Approved, Illicit
MifepristoneMifepristone may increase the QTc-prolonging activities of Hydroxyzine.Approved, Investigational
MilnacipranThe risk or severity of adverse effects can be increased when Hydroxyzine is combined with Milnacipran.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Hydroxyzine.Approved, Investigational
MirtazapineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MMDAMMDA may decrease the sedative activities of Hydroxyzine.Experimental, Illicit
MolindoneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Molindone.Approved
MorphineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Morphine.Approved, Investigational
MoxifloxacinHydroxyzine may increase the QTc-prolonging activities of Moxifloxacin.Approved, Investigational
NabiloneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.Approved, Investigational
NalbuphineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Nalbuphine.Approved
NefazodoneThe risk or severity of adverse effects can be increased when Hydroxyzine is combined with Nefazodone.Approved, Withdrawn
NilotinibHydroxyzine may increase the QTc-prolonging activities of Nilotinib.Approved, Investigational
NitrazepamHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Nitrazepam.Approved
Nitrous oxideHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.Approved, Vet Approved
NormethadoneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Normethadone.Approved, Illicit
NortriptylineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Nortriptyline.Approved
OfloxacinHydroxyzine may increase the QTc-prolonging activities of Ofloxacin.Approved
OlanzapineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Olanzapine.Approved, Investigational
OlopatadineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Olopatadine.Approved
OndansetronHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Ondansetron.Approved
OpiumHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Opium.Approved, Illicit
OrphenadrineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Osanetant.Investigational
OxazepamHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Oxazepam.Approved
OxetacaineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Oxetacaine.Investigational
OxprenololHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Oxprenolol.Approved
OxybuprocaineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Oxybuprocaine.Approved
OxycodoneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Oxycodone.Approved, Illicit, Investigational
OxymorphoneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Oxymorphone.Approved, Investigational, Vet Approved
PaliperidoneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Paliperidone.Approved
PanobinostatHydroxyzine may increase the QTc-prolonging activities of Panobinostat.Approved, Investigational
ParaldehydeHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ParoxetineThe risk or severity of adverse effects can be increased when Hydroxyzine is combined with Paroxetine.Approved, Investigational
PazopanibHydroxyzine may increase the QTc-prolonging activities of Pazopanib.Approved
PentamidineHydroxyzine may increase the QTc-prolonging activities of Pentamidine.Approved
PentazocineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Pentazocine.Approved, Vet Approved
PentobarbitalHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Pentobarbital.Approved, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Hydroxyzine.Approved
PerazineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Perazine.Investigational
PerflutrenHydroxyzine may increase the QTc-prolonging activities of Perflutren.Approved
PerospironeHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Perospirone.Approved
PerphenazineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Perphenazine.Approved
PethidineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Pethidine.Approved
PhenobarbitalHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Phenobarbital.Approved
PhenoxyethanolHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Phenoxyethanol.Approved
PhenterminePhentermine may decrease the sedative activities of Hydroxyzine.Approved, Illicit
PhenytoinHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Phenytoin.Approved, Vet Approved
PimozideHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Pimozide.Approved
PipamperoneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Pipamperone.Approved
PipotiazineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Pipotiazine.Approved
PiritramideHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Piritramide.Investigational
PizotifenHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Pizotifen.Approved
PomalidomideHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Pomalidomide.Approved
PramipexoleHydroxyzine may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Pramocaine.Approved
PrazepamHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Prazepam.Approved, Illicit
PregabalinHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.Approved, Illicit, Investigational
PregnanoloneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Pregnanolone.Investigational
PrilocaineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Prilocaine.Approved
PrimaquineHydroxyzine may increase the QTc-prolonging activities of Primaquine.Approved
PrimidoneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Primidone.Approved, Vet Approved
ProcainamideHydroxyzine may increase the QTc-prolonging activities of Procainamide.Approved
ProcaineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Procaine.Approved, Investigational, Vet Approved
ProchlorperazineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Prochlorperazine.Approved, Vet Approved
PromazineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Promazine.Approved, Vet Approved
PromethazineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Promethazine.Approved
PropafenoneHydroxyzine may increase the QTc-prolonging activities of Propafenone.Approved
ProparacaineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Proparacaine.Approved, Vet Approved
PropofolHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Propofol.Approved, Investigational, Vet Approved
PropoxycaineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Propoxycaine.Approved
ProtriptylineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Protriptyline.Approved
PSD502Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of PSD502.Investigational
PseudoephedrinePseudoephedrine may decrease the sedative activities of Hydroxyzine.Approved
QuazepamHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Quazepam.Approved, Illicit
QuetiapineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Quetiapine.Approved
QuinidineHydroxyzine may increase the QTc-prolonging activities of Quinidine.Approved
QuinineHydroxyzine may increase the QTc-prolonging activities of Quinine.Approved
RacloprideHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Raclopride.Investigational
RamelteonHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Ramelteon.Approved, Investigational
RemifentanilHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Remifentanil.Approved
RemoxiprideHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Remoxipride.Approved, Withdrawn
ReserpineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Reserpine.Approved
RisperidoneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Risperidone.Approved, Investigational
RitanserinHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Ritanserin.Investigational
RitobegronRitobegron may decrease the sedative activities of Hydroxyzine.Investigational
RomifidineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Romifidine.Vet Approved
RopiniroleHydroxyzine may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Ropivacaine.Approved
RotigotineHydroxyzine may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Hydroxyzine.Approved
S-EthylisothioureaHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of S-Ethylisothiourea.Experimental
Sage 547Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Sage 547.Investigational
SaquinavirHydroxyzine may increase the QTc-prolonging activities of Saquinavir.Approved, Investigational
ScopolamineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Scopolamine.Approved
SecobarbitalHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Secobarbital.Approved, Vet Approved
SertindoleHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Sertindole.Approved, Withdrawn
SertralineThe risk or severity of adverse effects can be increased when Hydroxyzine is combined with Sertraline.Approved
SevofluraneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Sevoflurane.Approved, Vet Approved
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Hydroxyzine.Approved
SotalolHydroxyzine may increase the QTc-prolonging activities of Sotalol.Approved
StiripentolHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Stiripentol.Approved
SufentanilHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Sufentanil.Approved, Investigational
SulfisoxazoleHydroxyzine may increase the QTc-prolonging activities of Sulfisoxazole.Approved, Vet Approved
SulpirideHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Sulpiride.Approved
SuvorexantHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
TandospironeHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Hydroxyzine.Approved
TasimelteonHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Tasimelteon.Approved
TelavancinHydroxyzine may increase the QTc-prolonging activities of Telavancin.Approved
TelithromycinHydroxyzine may increase the QTc-prolonging activities of Telithromycin.Approved
TemazepamHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Temazepam.Approved
TetrabenazineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Tetrabenazine.Approved
TetracaineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Tetracaine.Approved, Vet Approved
TetrodotoxinHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Tetrodotoxin.Investigational
ThalidomideHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
ThiamylalHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Thiamylal.Approved, Vet Approved
ThiopentalHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Thiopental.Approved, Vet Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Hydroxyzine.Approved
ThiothixeneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Thiothixene.Approved
TiagabineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Tiagabine.Approved
TiaprideHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Tiapride.Investigational
TiletamineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Tiletamine.Vet Approved
TizanidineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Tizanidine.Approved
TolcaponeHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Tolcapone.Approved, Withdrawn
TopiramateHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Topiramate.Approved
ToremifeneHydroxyzine may increase the QTc-prolonging activities of Toremifene.Approved, Investigational
TramadolHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Tramadol.Approved, Investigational
Trans-2-PhenylcyclopropylamineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Trans-2-Phenylcyclopropylamine.Experimental
TranylcypromineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Tranylcypromine.Approved
TrazodoneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Trazodone.Approved, Investigational
TriazolamHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Triazolam.Approved
TrifluoperazineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Trifluoperazine.Approved
TriflupromazineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Triflupromazine.Approved, Vet Approved
TrimipramineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Trimipramine.Approved
TriprolidineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Triprolidine.Approved
Uc1010Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Uc1010.Investigational
Valproic AcidHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Valproic Acid.Approved, Investigational
VandetanibHydroxyzine may increase the QTc-prolonging activities of Vandetanib.Approved
VemurafenibHydroxyzine may increase the QTc-prolonging activities of Vemurafenib.Approved
VenlafaxineThe risk or severity of adverse effects can be increased when Hydroxyzine is combined with Venlafaxine.Approved
VigabatrinHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Vigabatrin.Approved
VortioxetineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Vortioxetine.Approved
XylazineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Xylazine.Vet Approved
YohimbineThe therapeutic efficacy of Hydroxyzine can be decreased when used in combination with Yohimbine.Approved, Vet Approved
ZaleplonHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Zaleplon.Approved, Illicit, Investigational
ZiconotideHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Ziconotide.Approved
ZimelidineThe risk or severity of adverse effects can be increased when Hydroxyzine is combined with Zimelidine.Withdrawn
ZiprasidoneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Ziprasidone.Approved
ZolazepamHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Zolazepam.Vet Approved
ZolpidemHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Zonisamide.Approved, Investigational
ZopicloneHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Zopiclone.Approved
ZotepineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Zotepine.Approved
ZuclopenthixolHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Zuclopenthixol.Approved, Investigational
Food Interactions
  • Avoid alcohol.
  • Take with food.
References
Synthesis Reference

U.S. Patent 2,899,436.

General References
  1. HUTCHEON DE, MORRIS DL, SCRIABINE A: Cardiovascular action of hydroxyzine (atarax). J Pharmacol Exp Ther. 1956 Dec;118(4):451-60. [PubMed:13385806 ]
  2. DOLAN CM: Management of emotional disturbances; use of hydroxyzine (atarax) in general practice. Calif Med. 1958 Jun;88(6):443-4. [PubMed:13536863 ]
  3. Clark BG, Araki M, Brown HW: Hydroxyzine-associated tardive dyskinesia. Ann Neurol. 1982 Apr;11(4):435. [PubMed:7103423 ]
External Links
ATC CodesN05BB51N05BB01
AHFS Codes
  • 28:24.92
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (73.5 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.8623
Blood Brain Barrier+0.9516
Caco-2 permeable-0.5565
P-glycoprotein substrateSubstrate0.7447
P-glycoprotein inhibitor IInhibitor0.8563
P-glycoprotein inhibitor IIInhibitor0.6394
Renal organic cation transporterInhibitor0.592
CYP450 2C9 substrateNon-substrate0.8352
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateNon-substrate0.7193
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorNon-inhibitor0.9111
CYP450 2D6 inhibitorInhibitor0.8535
CYP450 2C19 inhibitorNon-inhibitor0.9026
CYP450 3A4 inhibitorNon-inhibitor0.9623
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7615
Ames testNon AMES toxic0.7558
CarcinogenicityNon-carcinogens0.9102
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.6612 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.5929
hERG inhibition (predictor II)Inhibitor0.7898
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Baxter healthcare corp anesthesia and critical care
  • Altana inc
  • App pharmaceuticals llc
  • Hospira inc
  • Luitpold pharmaceuticals inc
  • Pharmafair inc
  • Smith and nephew solopak div smith and nephew
  • Solopak medical products inc
  • Solopak laboratories inc
  • Watson laboratories inc
  • Wyeth ayerst laboratories
  • Organon usa inc
  • Pfizer laboratories div pfizer inc
  • Roerig div pfizer inc
  • Actavis mid atlantic llc
  • Alpharma us pharmaceuticals division
  • Hi tech pharmacal co inc
  • Kv pharmaceutical co
  • Vintage pharmaceuticals inc
  • Wockhardt eu operations (swiss) ag
  • Pfizer inc
  • Able laboratories inc
  • Actavis totowa llc
  • Amneal pharmaceutical
  • Halsey drug co inc
  • Heritage pharmaceuticals inc
  • Hetero drugs ltd unit iii
  • Invagen pharmaceuticals inc
  • Ivax pharmaceuticals inc
  • Kvk tech inc
  • Mutual pharmaceutical co inc
  • Mylan pharmaceuticals inc
  • Northstar healthcare holdings ltd
  • Pliva inc
  • Purepac pharmaceutical co
  • Quantum pharmics ltd
  • Sandoz inc
  • Sun pharmaceutical industries inc
  • Superpharm corp
  • Usl pharma inc
  • Vintage pharmaceuticals llc
  • Barr laboratories inc
  • Duramed pharmaceuticals inc sub barr laboratories inc
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Par pharmaceutical inc
  • Vangard laboratories inc div midway medical co
  • Teva pharmaceuticals usa inc
Packagers
Dosage forms
FormRouteStrength
CapsuleOral10 mg
CapsuleOral25 mg
CapsuleOral50 mg
SolutionIntramuscular50 mg
SyrupOral2 mg
Injection, solutionIntramuscular25 mg/mL
Injection, solutionIntramuscular50 mg/mL
SolutionOral10 mg/5mL
SyrupOral10 mg/5mL
TabletOral10 mg/1
TabletOral25 mg/1
TabletOral50 mg/1
Tablet, film coatedOral10 mg/1
Tablet, film coatedOral25 mg/1
Tablet, film coatedOral50 mg/1
LiquidIntramuscular50 mg
CapsuleOral100 mg/1
CapsuleOral25 mg/1
CapsuleOral50 mg/1
SyrupOral10 mg
SolutionIntramuscular50 mg/mL
Prices
Unit descriptionCostUnit
Hydroxyzine Hcl 50 mg/ml4.42USD ml
Hydroxyzine 50 mg/ml vial3.96USD ml
Hydroxyzine 25 mg/ml vial3.6USD ml
Hydroxyzine hcl powder2.75USD g
Hydroxyzine pamoate powder2.14USD g
Vistaril 50 mg capsule2.03USD capsule
HydrOXYzine HCl 50 mg/ml vial1.78USD vial
Vistaril 25 mg capsule1.71USD capsule
Vistaril 100 mg capsule1.7USD capsule
Hydroxyzine hcl 50 mg tablet1.19USD tablet
Hydroxyzine hcl 10 mg tablet0.72USD tablet
Hydroxyzine hcl 25 mg tablet0.7USD tablet
HydrOXYzine Pamoate 100 mg capsule0.67USD capsule
Hydroxyzine pam 50 mg capsule0.64USD capsule
Hydroxyzine pam 100 mg capsule0.63USD capsule
Hydroxyzine pam 25 mg capsule0.46USD capsule
Vistaril 25 mg/5ml Suspension0.45USD ml
HydrOXYzine Pamoate 25 mg capsule0.3USD capsule
HydrOXYzine Pamoate 50 mg capsule0.23USD capsule
Apo-Hydroxyzine 50 mg Capsule0.22USD capsule
Novo-Hydroxyzin 50 mg Capsule0.22USD capsule
Apo-Hydroxyzine 25 mg Capsule0.15USD capsule
Novo-Hydroxyzin 25 mg Capsule0.15USD capsule
HydrOXYzine HCl 10 mg/5ml Syrup0.13USD ml
Apo-Hydroxyzine 10 mg Capsule0.12USD capsule
Novo-Hydroxyzin 10 mg Capsule0.12USD capsule
Atarax 2 mg/ml Syrup0.06USD ml
Pms-Hydroxyzine 2 mg/ml Syrup0.04USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point193 °CU.S. Patent 2,899,436.
water solubility< 700 mg/mLNot Available
logP2.7Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0914 mg/mLALOGPS
logP3.43ALOGPS
logP3.41ChemAxon
logS-3.6ALOGPS
pKa (Strongest Acidic)15.12ChemAxon
pKa (Strongest Basic)7.82ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area35.94 Å2ChemAxon
Rotatable Bond Count8ChemAxon
Refractivity107.07 m3·mol-1ChemAxon
Polarizability41.99 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
MSMass Spectrum (Electron Ionization)splash10-0uxr-4591000000-d2e3424c44feae8a5d9cView in MoNA
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassDiphenylmethanes
Direct ParentDiphenylmethanes
Alternative Parents
Substituents
  • Diphenylmethane
  • Aralkylamine
  • N-alkylpiperazine
  • Halobenzene
  • Chlorobenzene
  • Piperazine
  • 1,4-diazinane
  • Aryl halide
  • Aryl chloride
  • Tertiary aliphatic amine
  • Tertiary amine
  • Azacycle
  • Organoheterocyclic compound
  • Ether
  • Dialkyl ether
  • Hydrocarbon derivative
  • Primary alcohol
  • Organooxygen compound
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Amine
  • Alcohol
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External DescriptorsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Histamine receptor activity
Specific Function:
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
Gene Name:
HRH1
Uniprot ID:
P35367
Molecular Weight:
55783.61 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  2. Spahr L, Coeytaux A, Giostra E, Hadengue A, Annoni JM: Histamine H1 blocker hydroxyzine improves sleep in patients with cirrhosis and minimal hepatic encephalopathy: a randomized controlled pilot trial. Am J Gastroenterol. 2007 Apr;102(4):744-53. Epub 2007 Jan 11. [PubMed:17222324 ]
  3. Sakaguchi T, Itoh H, Ding WG, Tsuji K, Nagaoka I, Oka Y, Ashihara T, Ito M, Yumoto Y, Zenda N, Higashi Y, Takeyama Y, Matsuura H, Horie M: Hydroxyzine, a first generation H(1)-receptor antagonist, inhibits human ether-a-go-go-related gene (HERG) current and causes syncope in a patient with the HERG mutation. J Pharmacol Sci. 2008 Dec;108(4):462-71. Epub 2008 Dec 5. [PubMed:19057127 ]
  4. Chen C: Physicochemical, pharmacological and pharmacokinetic properties of the zwitterionic antihistamines cetirizine and levocetirizine. Curr Med Chem. 2008;15(21):2173-91. [PubMed:18781943 ]
  5. Snowman AM, Snyder SH: Cetirizine: actions on neurotransmitter receptors. J Allergy Clin Immunol. 1990 Dec;86(6 Pt 2):1025-8. [PubMed:1979798 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Hamelin BA, Bouayad A, Drolet B, Gravel A, Turgeon J: In vitro characterization of cytochrome P450 2D6 inhibition by classic histamine H1 receptor antagonists. Drug Metab Dispos. 1998 Jun;26(6):536-9. [PubMed:9616188 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Comments
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Drug created on June 13, 2005 07:24 / Updated on December 08, 2016 11:46