UGT1A4 substrates

DrugDrug NameDrug Description
DB00555LamotrigineA phenyltriazine antiepileptic used to treat some types of epilepsy and bipolar I disorder.
DB00910ParicalcitolA vitamin D analog used to treat hyperparathyroidism associated with stage 3 or greater chronic kidney disease.
DB00831TrifluoperazineA phenothiazine used to treat depression, anxiety, and agitation.
DB00363ClozapineAn antipsychotic drug used in treatment resistant schizophrenia and to decrease suicide risk in schizophrenic patients.
DB00197TroglitazoneFor the treatment of Type II diabetes mellitus. It is used alone or in combination with a sulfonylurea, metformin, or insulin as an adjunct to diet and exercise.
DB04953EzogabineAn antiepileptic agent used as an adjuvant treatment of partial-onset seizures.
DB06216AsenapineAn atypical antipsychotic used to treat patients with bipolar I disorder and patients with schizophrenia.
DB00683MidazolamA short-acting injectable benzodiazepine with rapid onset that is commonly used in seizures, anesthesia and anxiety disorders.
DB00313Valproic acidAn anticonvulsant used to control complex partial seizures and both simple and complex absence seizures.
DB09262ImidafenacinUsed in the treatment of overactive bladder [FDA Label].
DB13874EnasidenibAn isocitrate dehydrogenase-2 inhibitor used to treat relapsed or refractory acute myeloid leukemia with an isocitrate dehydrogenase-2 mutation.
DB00334OlanzapineAn antipsychotic drug used in the management of schizophrenia, bipolar 1 disorder, and agitation associated with these disorders.
DB12978PexidartinibAn antitumor agent that is used for the treatment of rare disease tenosynovial giant cell tumors (TGCT) by inhibiting colony-stimulating factor 1 and its receptor.
DB09054IdelalisibAn antineoplastic kinase inhibitor used to treat chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL).
DB00924CyclobenzaprineA skeletal muscle relaxant that works on the brainstem to treat muscle spasms of local origin.
DB12020TecovirimatAn antiviral medication used to treat smallpox.
DB01217AnastrozoleA competitive, selective, non-steroidal aromatase inhibitor used as adjuvant therapy for the treatment of hormone receptor-positive breast cancer in postmenopausal women.
DB00321AmitriptylineA tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety.
DB06077LumateperoneA novel 2nd generation antipsychotic used to manage both positive and negative symptoms in patients with schizophrenia.
DB00252PhenytoinAn anticonvulsant drug used in the prophylaxis and control of various types of seizures.
DB00977EthinylestradiolAn estradiol used as a contraceptive.
DrugDrug NameTargetType
DB00555LamotrigineSodium channel protein type 2 subunit alphatarget
DB00555LamotrigineUDP-glucuronosyltransferase 1-4enzyme
DB00555LamotrigineP-glycoprotein 1transporter
DB00555LamotrigineUDP-glucuronosyltransferase 1-3enzyme
DB00555LamotrigineDihydrofolate reductaseenzyme
DB00555Lamotrigine5-hydroxytryptamine receptor 3Atarget
DB00555LamotrigineVoltage-dependent R-type calcium channel subunit alpha-1E (CACNA1E)target
DB00555LamotrigineAdenosine receptor A1target
DB00555LamotrigineAdenosine receptor A2atarget
DB00555LamotrigineAlpha-1A adrenergic receptortarget
DB00555LamotrigineAlpha-2A adrenergic receptortarget
DB00555LamotrigineBeta-1 adrenergic receptortarget
DB00555LamotrigineD(1) dopamine receptortarget
DB00555LamotrigineDopamine D2 receptortarget
DB00555LamotrigineGABA-A receptor (anion channel)target
DB00555LamotrigineGABA-A receptor (benzodiazepine site)target
DB00555LamotrigineHistamine H1 receptortarget
DB00555LamotrigineKappa-type opioid receptortarget
DB00555LamotrigineMuscarinic acetylcholine receptortarget
DB00555Lamotrigine5-hydroxytryptamine receptor 2Atarget
DB00555LamotrigineUDP-glucuronosyltransferase 1-1enzyme
DB00555LamotrigineSolute carrier family 22 member 2transporter
DB00910ParicalcitolVitamin D3 receptortarget
DB00910Paricalcitol1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
DB00910ParicalcitolCytochrome P450 3A4enzyme
DB00910ParicalcitolUDP-glucuronosyltransferase 1-4enzyme
DB00831TrifluoperazineDopamine D2 receptortarget
DB00831TrifluoperazineAlpha-1A adrenergic receptortarget
DB00831TrifluoperazineNeuron-specific vesicular protein calcyontarget
DB00831TrifluoperazineXanthine dehydrogenase/oxidaseenzyme
DB00831TrifluoperazineUDP-glucuronosyltransferase 1-4enzyme
DB00831TrifluoperazineCytochrome P450 1A2enzyme
DB00831TrifluoperazineP-glycoprotein 1transporter
DB00831TrifluoperazineCalmodulintarget
DB00831TrifluoperazineTroponin C, slow skeletal and cardiac musclestarget
DB00831TrifluoperazineProtein S100-A4target
DB00363ClozapineDopamine D4 receptortarget
DB00363ClozapineHistamine H1 receptortarget
DB00363ClozapineDopamine D2 receptortarget
DB00363ClozapineNeuron-specific vesicular protein calcyontarget
DB00363ClozapineHistamine H4 receptortarget
DB00363Clozapine5-hydroxytryptamine receptor 2Atarget
DB00363Clozapine5-hydroxytryptamine receptor 1Atarget
DB00363Clozapine5-hydroxytryptamine receptor 2Ctarget
DB00363ClozapineDopamine D1 receptortarget
DB00363ClozapineCytochrome P450 1A2enzyme
DB00363ClozapineCytochrome P450 2D6enzyme
DB00363ClozapineDopamine D3 receptortarget
DB00363ClozapineMuscarinic acetylcholine receptor M1target
DB00363ClozapineMuscarinic acetylcholine receptor M2target
DB00363ClozapineMuscarinic acetylcholine receptor M3target
DB00363ClozapineMuscarinic acetylcholine receptor M4target
DB00363ClozapineMuscarinic acetylcholine receptor M5target
DB00363Clozapine5-hydroxytryptamine receptor 1Btarget
DB00363Clozapine5-hydroxytryptamine receptor 1Dtarget
DB00363Clozapine5-hydroxytryptamine receptor 1Etarget
DB00363Clozapine5-hydroxytryptamine receptor 3Atarget
DB00363Clozapine5-hydroxytryptamine receptor 6target
DB00363Clozapine5-hydroxytryptamine receptor 7target
DB00363ClozapineAlpha-1A adrenergic receptortarget
DB00363ClozapineAlpha-1B adrenergic receptortarget
DB00363ClozapineAlpha-2A adrenergic receptortarget
DB00363ClozapineAlpha-2B adrenergic receptortarget
DB00363ClozapineAlpha-2C adrenergic receptortarget
DB00363ClozapineCytochrome P450 2C9enzyme
DB00363ClozapineP-glycoprotein 1transporter
DB00363ClozapineCytochrome P450 3A4enzyme
DB00363ClozapineCytochrome P450 2C19enzyme
DB00363ClozapineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB00363ClozapineUDP-glucuronosyltransferase 1-4enzyme
DB00363ClozapineCytochrome P450 1A1enzyme
DB00363ClozapineCytochrome P450 2A6enzyme
DB00363ClozapineCytochrome P450 2C8enzyme
DB00363ClozapineGlutathione S-transferase Ptarget
DB00197TroglitazonePeroxisome proliferator-activated receptor gammatarget
DB00197TroglitazoneLong-chain-fatty-acid--CoA ligase 4target
DB00197TroglitazonePlasminogen activator inhibitor 1target
DB00197TroglitazoneEquilibrative nucleoside transporter 1target
DB00197TroglitazoneCytochrome P450 3A4enzyme
DB00197TroglitazoneCytochrome P450 2C19enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 1-1enzyme
DB00197TroglitazoneCytochrome P450 2C8enzyme
DB00197TroglitazoneBile salt export pumptransporter
DB00197TroglitazoneSolute carrier organic anion transporter family member 1B1transporter
DB00197TroglitazoneEstrogen-related receptor gammatarget
DB00197TroglitazoneSteroid hormone receptor ERR1target
DB00197TroglitazoneCytochrome P450 19A1enzyme
DB00197TroglitazoneCytochrome P450 1A1enzyme
DB00197TroglitazoneCytochrome P450 2B6enzyme
DB00197TroglitazoneCytochrome P450 2C9enzyme
DB00197TroglitazoneCytochrome P450 3A5enzyme
DB00197TroglitazoneCytochrome P450 3A7enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 1-3enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 1-4enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 1-6enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 1-7enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 1-8enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 1-9enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 1-10enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 2B7enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 2B15enzyme
DB00197TroglitazonePeroxisome proliferator-activated receptor deltatarget
DB00197TroglitazonePeroxisome proliferator-activated receptor alphatarget
DB00197TroglitazoneGlutathione S-transferase Ptarget
DB04953EzogabinePotassium voltage-gated channel subfamily KQT member 2target
DB04953EzogabinePotassium voltage-gated channel subfamily KQT member 3target
DB04953EzogabinePotassium voltage-gated channel subfamily KQT member 4target
DB04953EzogabinePotassium voltage-gated channel subfamily KQT member 5target
DB04953EzogabineUDP-glucuronosyltransferase 1-1enzyme
DB04953EzogabineUDP-glucuronosyltransferase 1-3enzyme
DB04953EzogabineUDP-glucuronosyltransferase 1-4enzyme
DB04953EzogabineUDP-glucuronosyltransferase 1-9enzyme
DB04953EzogabineArylamine N-acetyltransferase 2enzyme
DB06216Asenapine5-hydroxytryptamine receptor 1Atarget
DB06216Asenapine5-hydroxytryptamine receptor 1Btarget
DB06216Asenapine5-hydroxytryptamine receptor 2Atarget
DB06216Asenapine5-hydroxytryptamine receptor 2Btarget
DB06216Asenapine5-hydroxytryptamine receptor 2Ctarget
DB06216Asenapine5-hydroxytryptamine receptor 6target
DB06216Asenapine5-hydroxytryptamine receptor 7target
DB06216AsenapineAlpha-2A adrenergic receptortarget
DB06216AsenapineAlpha-2B adrenergic receptortarget
DB06216AsenapineAlpha-2C adrenergic receptortarget
DB06216AsenapineAlpha-1A adrenergic receptortarget
DB06216AsenapineDopamine D1 receptortarget
DB06216AsenapineDopamine D2 receptortarget
DB06216AsenapineDopamine D3 receptortarget
DB06216AsenapineDopamine D4 receptortarget
DB06216AsenapineHistamine H1 receptortarget
DB06216AsenapineHistamine H2 receptortarget
DB06216AsenapineCytochrome P450 1A2enzyme
DB06216AsenapineCytochrome P450 2D6enzyme
DB06216Asenapine5-hydroxytryptamine receptor 5Atarget
DB06216AsenapineUDP-glucuronosyltransferase 1-4enzyme
DB06216AsenapineCytochrome P450 3A4enzyme
DB06216AsenapineBeta-1 adrenergic receptortarget
DB06216AsenapineBeta-2 adrenergic receptortarget
DB06216AsenapineSerum albumincarrier
DB06216Asenapinealpha1-acid glycoproteincarrier
DB00683MidazolamGamma-aminobutyric acid receptor subunit alpha-1target
DB00683MidazolamGamma-aminobutyric acid receptor subunit alpha-5target
DB00683MidazolamGamma-aminobutyric acid receptor subunit alpha-3target
DB00683MidazolamGamma-aminobutyric acid receptor subunit alpha-2target
DB00683MidazolamGamma-aminobutyric acid receptor subunit alpha-4target
DB00683MidazolamGamma-aminobutyric acid receptor subunit alpha-6target
DB00683MidazolamCytochrome P450 3A4enzyme
DB00683MidazolamCytochrome P450 3A5enzyme
DB00683MidazolamUDP-glucuronosyltransferase 1-4enzyme
DB00683MidazolamCytochrome P450 3A7enzyme
DB00313Valproic acidHistone deacetylase 9target
DB00313Valproic acidShort/branched chain specific acyl-CoA dehydrogenase, mitochondrialtarget
DB00313Valproic acidCytochrome P450 2A6enzyme
DB00313Valproic acidCytochrome P450 2B6enzyme
DB00313Valproic acidCytochrome P450 2C9enzyme
DB00313Valproic acidSolute carrier family 22 member 5transporter
DB00313Valproic acidSolute carrier family 22 member 6transporter
DB00313Valproic acidSolute carrier family 22 member 8transporter
DB00313Valproic acidMonocarboxylate transporter 1transporter
DB00313Valproic acidSolute carrier family 22 member 7transporter
DB00313Valproic acidCytochrome P450 3A5enzyme
DB00313Valproic acidUDP-glucuronosyltransferase 1-9enzyme
DB00313Valproic acidProstaglandin G/H synthase 1enzyme
DB00313Valproic acidCytochrome P450 1A2enzyme
DB00313Valproic acidCytochrome P450 2C19enzyme
DB00313Valproic acidCytochrome P450 3A4enzyme
DB00313Valproic acidUDP-glucuronosyltransferase 1-4enzyme
DB00313Valproic acidUDP-glucuronosyltransferase 1-8enzyme
DB00313Valproic acidUDP-glucuronosyltransferase 1-10enzyme
DB00313Valproic acidUDP-glucuronosyltransferase 1-6enzyme
DB00313Valproic acidUDP-glucuronosyltransferase 1-3enzyme
DB00313Valproic acidUDP-glucuronosyltransferase 2B7enzyme
DB00313Valproic acidUDP-glucuronosyltransferase 2B15enzyme
DB00313Valproic acid2-oxoglutarate dehydrogenase, mitochondrialtarget
DB00313Valproic acidSuccinate-semialdehyde dehydrogenase, mitochondrialtarget
DB00313Valproic acidSodium channel proteintarget
DB00313Valproic acidHistone deacetylase 2target
DB00313Valproic acidPeroxisome proliferator-activated receptor alphatarget
DB00313Valproic acidPeroxisome proliferator-activated receptor deltatarget
DB00313Valproic acidPeroxisome proliferator-activated receptor gammatarget
DB00313Valproic acidSerum albumincarrier
DB00313Valproic acidUDP-glucuronosyltransferase 1-1enzyme
DB00313Valproic acidSolute carrier organic anion transporter family member 2B1transporter
DB09262ImidafenacinMuscarinic acetylcholine receptor M1target
DB09262ImidafenacinMuscarinic acetylcholine receptor M2target
DB09262ImidafenacinMuscarinic acetylcholine receptor M3target
DB09262ImidafenacinCytochrome P450 3A4enzyme
DB09262ImidafenacinUDP-glucuronosyltransferase 1-4enzyme
DB09262ImidafenacinSerum albumincarrier
DB09262Imidafenacinalpha1-acid glycoproteincarrier
DB13874EnasidenibCytochrome P450 1A2enzyme
DB13874EnasidenibCytochrome P450 2B6enzyme
DB13874EnasidenibIsocitrate dehydrogenase [NADP], mitochondrialtarget
DB13874EnasidenibCytochrome P450 2C8enzyme
DB13874EnasidenibCytochrome P450 2C9enzyme
DB13874EnasidenibCytochrome P450 2C19enzyme
DB13874EnasidenibCytochrome P450 2D6enzyme
DB13874EnasidenibCytochrome P450 3A4enzyme
DB13874EnasidenibUDP-glucuronosyltransferase 1-1enzyme
DB13874EnasidenibUDP-glucuronosyltransferase 1-3enzyme
DB13874EnasidenibUDP-glucuronosyltransferase 1-4enzyme
DB13874EnasidenibUDP-glucuronosyltransferase 1-9enzyme
DB13874EnasidenibUDP-glucuronosyltransferase 2B7enzyme
DB13874EnasidenibUDP-glucuronosyltransferase 2B15enzyme
DB13874EnasidenibP-glycoprotein 1transporter
DB13874EnasidenibATP-binding cassette sub-family G member 2transporter
DB13874EnasidenibSolute carrier family 22 member 6transporter
DB13874EnasidenibSolute carrier organic anion transporter family member 1B1transporter
DB13874EnasidenibSolute carrier family 22 member 2transporter
DB13874EnasidenibSolute carrier organic anion transporter family member 1B3transporter
DB13874EnasidenibSolute carrier family 22 member 8transporter
DB00334OlanzapineDopamine D1 receptortarget
DB00334OlanzapineMuscarinic acetylcholine receptor M1target
DB00334OlanzapineMuscarinic acetylcholine receptor M3target
DB00334Olanzapine5-hydroxytryptamine receptor 2Atarget
DB00334OlanzapineDopamine D4 receptortarget
DB00334OlanzapineHistamine H1 receptortarget
DB00334OlanzapineMuscarinic acetylcholine receptor M4target
DB00334OlanzapineMuscarinic acetylcholine receptor M2target
DB00334OlanzapineDopamine D2 receptortarget
DB00334Olanzapine5-hydroxytryptamine receptor 2Ctarget
DB00334OlanzapineDopamine D3 receptortarget
DB00334OlanzapineAlpha-1B adrenergic receptortarget
DB00334OlanzapineCytochrome P450 1A2enzyme
DB00334Olanzapine5-hydroxytryptamine receptor 3Atarget
DB00334Olanzapine5-hydroxytryptamine receptor 6target
DB00334OlanzapineAlpha-1A adrenergic receptortarget
DB00334OlanzapineDopamine D5 receptortarget
DB00334OlanzapineSerum albumincarrier
DB00334OlanzapineAlpha-1-acid glycoprotein 1carrier
DB00334OlanzapineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB00334OlanzapineCytochrome P450 2D6enzyme
DB00334OlanzapineP-glycoprotein 1transporter
DB00334OlanzapineCytochrome P450 2C19enzyme
DB00334OlanzapineD(1) dopamine receptortarget
DB00334OlanzapineBeta adrenergic receptortarget
DB00334Olanzapine5-hydroxytryptamine receptor 1target
DB00334OlanzapineGABA-A receptor (benzodiazepine site)target
DB00334OlanzapineCytochrome P450 2C9enzyme
DB00334OlanzapineUDP-glucuronosyltransferase 1-4enzyme
DB00334OlanzapineCytochrome P450 3A4enzyme
DB00334OlanzapineCytochrome P450 3A Subfamilyenzyme
DB12978PexidartinibCytochrome P450 3A4enzyme
DB12978PexidartinibUDP-glucuronosyltransferase 1-4enzyme
DB12978PexidartinibMacrophage colony-stimulating factor 1 receptortarget
DB12978PexidartinibCytochrome P450 2B6enzyme
DB12978PexidartinibCytochrome P450 2C9enzyme
DB12978PexidartinibUDP-glucuronosyltransferase 1-1enzyme
DB12978PexidartinibMultidrug and toxin extrusion protein 1transporter
DB12978PexidartinibMultidrug and toxin extrusion protein 2transporter
DB12978PexidartinibSolute carrier organic anion transporter family member 1B1transporter
DB12978PexidartinibSolute carrier organic anion transporter family member 1B3transporter
DB12978PexidartinibSolute carrier organic anion transporter family member 2B1transporter
DB12978PexidartinibSerum albumincarrier
DB12978PexidartinibAlpha-1-acid glycoprotein 1carrier
DB12978PexidartinibMast/stem cell growth factor receptor Kittarget
DB12978PexidartinibReceptor-type tyrosine-protein kinase FLT3target
DB12978PexidartinibPlatelet-derived growth factor receptor betatarget
DB09054IdelalisibPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget
DB09054IdelalisibATP-binding cassette sub-family G member 2transporter
DB09054IdelalisibP-glycoprotein 1transporter
DB09054IdelalisibAldehyde oxidaseenzyme
DB09054IdelalisibUDP-glucuronosyltransferase 1-4enzyme
DB09054IdelalisibUDP-glucuronosyltransferase 1-4enzyme
DB09054IdelalisibCytochrome P450 2C8enzyme
DB09054IdelalisibCytochrome P450 2C19enzyme
DB09054IdelalisibCytochrome P450 2B6enzyme
DB09054IdelalisibCytochrome P450 3A4enzyme
DB09054IdelalisibSolute carrier organic anion transporter family member 1B1transporter
DB09054IdelalisibSolute carrier organic anion transporter family member 1B3transporter
DB09054IdelalisibCytochrome P450 3A5enzyme
DB09054IdelalisibCytochrome P450 3A43enzyme
DB09054IdelalisibCytochrome P450 3A7enzyme
DB00924Cyclobenzaprine5-hydroxytryptamine receptor 2Atarget
DB00924CyclobenzaprineCytochrome P450 1A2enzyme
DB00924CyclobenzaprineCytochrome P450 3A4enzyme
DB00924CyclobenzaprineCytochrome P450 2D6enzyme
DB00924CyclobenzaprineSerum albumincarrier
DB00924CyclobenzaprineUDP-glucuronosyltransferase 1-4enzyme
DB00924CyclobenzaprineUDP-glucuronosyltransferase 2B10enzyme
DB00924Cyclobenzaprine5-hydroxytryptamine receptor 2Btarget
DB00924Cyclobenzaprine5-hydroxytryptamine receptor 2Ctarget
DB00924Cyclobenzaprine5-hydroxytryptamine receptor 7target
DB00924Cyclobenzaprine5-hydroxytryptamine receptor 6target
DB00924CyclobenzaprineSodium-dependent serotonin transportertarget
DB00924CyclobenzaprineSodium-dependent noradrenaline transportertarget
DB00924CyclobenzaprineToll-like receptor 4target
DB00924CyclobenzaprineAldehyde oxidasetarget
DB12020TecovirimatEnvelope protein F13target
DB12020TecovirimatUDP-glucuronosyltransferase 1-1enzyme
DB12020TecovirimatUDP-glucuronosyltransferase 1-4enzyme
DB01217AnastrozoleCytochrome P450 19A1target
DB01217AnastrozoleP-glycoprotein 1transporter
DB01217AnastrozoleCytochrome P450 3A4enzyme
DB01217AnastrozoleCytochrome P450 3A5enzyme
DB01217AnastrozoleCytochrome P450 2C8enzyme
DB01217AnastrozoleUDP-glucuronosyltransferase 1-4enzyme
DB01217AnastrozoleUDP-glucuronosyltransferase 1-3enzyme
DB01217AnastrozoleUDP-glucuronosyltransferase 2B7enzyme
DB01217AnastrozoleCytochrome P450 1A2enzyme
DB01217AnastrozoleCytochrome P450 2C9enzyme
DB00321AmitriptylineSodium-dependent serotonin transportertarget
DB00321AmitriptylineSodium-dependent noradrenaline transportertarget
DB00321AmitriptylinePotassium voltage-gated channel subfamily KQT member 2target
DB00321AmitriptylineAlpha-2A adrenergic receptortarget
DB00321AmitriptylineCytochrome P450 1A2enzyme
DB00321AmitriptylineCytochrome P450 2C19enzyme
DB00321AmitriptylineCytochrome P450 2D6enzyme
DB00321AmitriptylineSerum albumincarrier
DB00321AmitriptylineAlpha-1-acid glycoprotein 1carrier
DB00321AmitriptylineHistamine H1 receptortarget
DB00321Amitriptyline5-hydroxytryptamine receptor 2Atarget
DB00321Amitriptyline5-hydroxytryptamine receptor 1Atarget
DB00321AmitriptylineAlpha-1A adrenergic receptortarget
DB00321AmitriptylineCytochrome P450 3A4enzyme
DB00321AmitriptylineCytochrome P450 3A5enzyme
DB00321AmitriptylinePotassium voltage-gated channel subfamily A member 1target
DB00321AmitriptylineAlpha-1D adrenergic receptortarget
DB00321AmitriptylineDelta-type opioid receptortarget
DB00321AmitriptylineKappa-type opioid receptortarget
DB00321AmitriptylineHigh affinity nerve growth factor receptortarget
DB00321AmitriptylineBDNF/NT-3 growth factors receptortarget
DB00321AmitriptylineCytochrome P450 2C9enzyme
DB00321AmitriptylineCytochrome P450 2B6enzyme
DB00321AmitriptylineCytochrome P450 2C8enzyme
DB00321AmitriptylineHistamine H2 receptortarget
DB00321AmitriptylineHistamine H4 receptortarget
DB00321AmitriptylineSigma non-opioid intracellular receptor 1target
DB00321Amitriptyline5-hydroxytryptamine receptor 2Ctarget
DB00321AmitriptylineAlpha-1B adrenergic receptortarget
DB00321Amitriptyline5-hydroxytryptamine receptor 7target
DB00321Amitriptyline5-hydroxytryptamine receptor 1Dtarget
DB00321AmitriptylineMu-type opioid receptortarget
DB00321Amitriptyline5-hydroxytryptamine receptor 1Btarget
DB00321Amitriptyline5-hydroxytryptamine receptor 6target
DB00321AmitriptylinePotassium voltage-gated channel subfamily KQT member 3target
DB00321AmitriptylineUDP-glucuronosyltransferase 2B10enzyme
DB00321Amitriptyline5-hydroxytryptamine receptor 1Ctarget
DB00321AmitriptylineMuscarinic acetylcholine receptortarget
DB00321AmitriptylineHERG human cardiac K+ channeltarget
DB00321AmitriptylineP-glycoprotein 1transporter
DB00321AmitriptylineUDP-glucuronosyltransferase 1-4enzyme
DB06077Lumateperone5-hydroxytryptamine receptor 2Atarget
DB06077LumateperoneDopamine D2 receptortarget
DB06077LumateperoneDopamine D1 receptortarget
DB06077LumateperoneSodium-dependent serotonin transportertarget
DB06077LumateperoneGlutamate receptor ionotropic, NMDA 2Btarget
DB06077LumateperoneAldo-keto reductase familyenzyme
DB06077LumateperoneCytochrome P450 3A4enzyme
DB06077LumateperoneCytochrome P450 2C8enzyme
DB06077LumateperoneCytochrome P450 1A2enzyme
DB06077LumateperoneUDP-glucuronosyltransferase 1-1enzyme
DB06077LumateperoneUDP-glucuronosyltransferase 1-4enzyme
DB06077LumateperoneUDP-glucuronosyltransferase 2B15enzyme
DB06077LumateperoneAldo-keto reductase family 1 member C1enzyme
DB06077LumateperoneAldo-keto reductase family 1 member B10enzyme
DB06077LumateperoneAldo-keto reductase family 1 member C4enzyme
DB00252PhenytoinSodium channel protein type 5 subunit alphatarget
DB00252PhenytoinSodium channel protein type 1 subunit alphatarget
DB00252PhenytoinCytochrome P450 2C8enzyme
DB00252PhenytoinCytochrome P450 2C19enzyme
DB00252PhenytoinCytochrome P450 2C9enzyme
DB00252PhenytoinCytochrome P450 2B6enzyme
DB00252PhenytoinCytochrome P450 3A5enzyme
DB00252PhenytoinSerum albumincarrier
DB00252PhenytoinCytochrome P450 3A4enzyme
DB00252PhenytoinSolute carrier organic anion transporter family member 1C1transporter
DB00252PhenytoinP-glycoprotein 1transporter
DB00252PhenytoinCanalicular multispecific organic anion transporter 1transporter
DB00252PhenytoinCytochrome P450 11B1, mitochondrialenzyme
DB00252PhenytoinCytochrome P450 3A7enzyme
DB00252PhenytoinNuclear receptor subfamily 1 group I member 2target
DB00252PhenytoinSodium channel subunit beta-1target
DB00252PhenytoinSodium channel protein type 3 subunit alphatarget
DB00252PhenytoinUDP-glucuronosyltransferase 1-1enzyme
DB00252PhenytoinUDP-glucuronosyltransferase 1-6enzyme
DB00252PhenytoinUDP-glucuronosyltransferase 1-9enzyme
DB00252PhenytoinThyroxine-binding globulincarrier
DB00252PhenytoinPotassium voltage-gated channel subfamily H member 2target
DB00252PhenytoinVoltage-dependent L-type calcium channeltarget
DB00252PhenytoinSodium channel protein type 2 subunit alphatarget
DB00252PhenytoinSodium channel protein type 8 subunit alphatarget
DB00252PhenytoinGABA-A receptor (anion channel)target
DB00252PhenytoinCytochrome P450 1A2enzyme
DB00252PhenytoinCytochrome P450 2A6enzyme
DB00252PhenytoinCytochrome P450 2D6enzyme
DB00252PhenytoinCytochrome P450 2E1enzyme
DB00252PhenytoinEpoxide hydrolase 1enzyme
DB00252PhenytoinUDP-glucuronosyltransferase 1-4enzyme
DB00252PhenytoinCatechol O-methyltransferaseenzyme
DB00252PhenytoinNAD(P)H dehydrogenase [quinone] 1enzyme
DB00252PhenytoinCytochrome P450 2C18enzyme
DB00977EthinylestradiolEstrogen receptor alphatarget
DB00977EthinylestradiolNuclear receptor subfamily 1 group I member 2target
DB00977EthinylestradiolCytochrome P450 3A4enzyme
DB00977EthinylestradiolCytochrome P450 2C8enzyme
DB00977EthinylestradiolBile salt export pumptransporter
DB00977EthinylestradiolSodium/bile acid cotransportertransporter
DB00977EthinylestradiolCanalicular multispecific organic anion transporter 1transporter
DB00977EthinylestradiolP-glycoprotein 1transporter
DB00977EthinylestradiolSex hormone-binding globulintarget
DB00977EthinylestradiolUDP-glucuronosyltransferase 1-1enzyme
DB00977EthinylestradiolCytochrome P450 2C19enzyme
DB00977EthinylestradiolUDP-glucuronosyltransferase 1-4enzyme
DB00977EthinylestradiolUDP-glucuronosyltransferase 1-9enzyme
DB00977EthinylestradiolCytochrome P450 2C9enzyme
DB00977EthinylestradiolCytochrome P450 1A2enzyme
DB00977EthinylestradiolEstrogen sulfotransferaseenzyme
DB00977EthinylestradiolSulfotransferase 1A3/1A4enzyme
DB00977EthinylestradiolCytochrome P450 3A5enzyme