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Identification
NameClemastine
Accession NumberDB00283  (APRD00875)
TypeSmall Molecule
GroupsApproved
DescriptionAn ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. [PubChem]
Structure
Thumb
Synonyms
(+)-(2R)-2-(2-(((R)-P-chloro-alpha-Methyl-alpha-phenylbenzyl)oxy)ethyl)-1-methylpyrrolidine
(+)-(2R)-2-[2-[[(R)-P-chloro-alpha-Methyl-alpha-phenylbenzyl]oxy]ethyl]-1-methylpyrrolidine
Clemastina
Clemastine
Clemastinum
Meclastin
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Clemastine FumarateTablet2.68 mg/1OralTeva Pharmaceuticals USA Inc1992-04-01Not applicableUs
Clemastine FumarateTablet2.68 mg/1OralSandoz Inc1993-10-312016-10-31Us
Clemastine FumarateSyrup.5 mg/mLOralQualitest Pharmaceuticals, Inc1997-12-172016-11-15Us
Clemastine FumarateTablet2.68 mg/1OralNorthwind Pharmaceuticals, LLC2014-04-28Not applicableUs
Clemastine FumarateSyrup.5 mg/mLOralSilarx Pharmaceuticals, Inc1997-12-17Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Allergy ReliefTablet1.34 mg/1OralCVS Pharmacy1996-08-28Not applicableUs
Clemastine FumarateTablet1.34 mg/1OralPhysicians Total Care, Inc.2008-06-27Not applicableUs
Clemastine FumarateTablet1.34 mg/1OralSandoz Inc1993-10-312016-10-31Us
Clemastine FumarateTablet1.34 mg/1OralCarilion Materials Management1993-10-31Not applicableUs
Dayhist AllergyTablet1.34 mg/1OralH E B1995-08-30Not applicableUs
Dayhist AllergyTablet1.34 mg/1OralPublix Super Markets Inc1996-11-20Not applicableUs
Dayhist AllergyTablet1.34 mg/1OralHy Vee Inc1996-06-21Not applicableUs
Dayhist Allergy 12 Hour ReliefTablet1.34 mg/1OralKroger Company1996-08-07Not applicableUs
Good Neighbor Pharmacy Dayhist AllergyTablet1.34 mg/1OralAmerisource Bergen1996-06-28Not applicableUs
Good Sense Dayhist AllergyTablet1.34 mg/1OralL Perrigo Company1996-07-11Not applicableUs
Leader AllerhistTablet1.34 mg/1OralCardinal Health1997-09-30Not applicableUs
Sunmark 12 Hour Allergy ReliefTablet1.34 mg/1OralMc Kesson2003-07-03Not applicableUs
Tavist AllergyTablet1.34 mg/1OralNovartis Consumer Health, Inc.2010-01-01Not applicableUs
Tavist Tablets 1mgTablet1 mgOralNovartis Consumer Health Canada Inc.1997-05-202014-07-23Canada
Topcare Dayhist AllergyTablet1.34 mg/1OralTopco Associates LLC1996-07-23Not applicableUs
Wal HistTablet1.34 mg/1OralWalgreen Company1996-05-31Not applicableUs
Wal Hist 12 Hour ReliefTablet1.34 mg/1OralWalgreen Company1996-05-31Not applicableUs
Unapproved/Other Products Not Available
International Brands
NameCompany
AgastenNovartis (Brazil)
Allerhist-1Not Available
TavegilNovartis
TavegylNovartis
TavistNovartis
Tavist-1Novartis
Brand mixtures
NameLabellerIngredients
Tavist-D TabletsNovartis Consumer Health Canada Inc.
Salts
Name/CASStructureProperties
Clemastine fumarate
14976-57-9
Thumb
  • InChI Key: PMGQWSIVQFOFOQ-YKVZVUFRSA-N
  • Monoisotopic Mass: 459.1812508
  • Average Mass: 459.97
DBSALT000901
Categories
UNII95QN29S1ID
CAS number15686-51-8
WeightAverage: 343.89
Monoisotopic: 343.170292166
Chemical FormulaC21H26ClNO
InChI KeyYNNUSGIPVFPVBX-NHCUHLMSSA-N
InChI
InChI=1S/C21H26ClNO/c1-21(17-7-4-3-5-8-17,18-10-12-19(22)13-11-18)24-16-14-20-9-6-15-23(20)2/h3-5,7-8,10-13,20H,6,9,14-16H2,1-2H3/t20-,21-/m1/s1
IUPAC Name
(2R)-2-{2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl}-1-methylpyrrolidine
SMILES
CN1CCC[C@@H]1CCO[C@](C)(C1=CC=CC=C1)C1=CC=C(Cl)C=C1
Pharmacology
IndicationFor the relief of symptoms associated with allergic rhinitis such as sneezing, rhinorrhea, pruritus and acrimation. Also for the management of mild, uncomplicated allergic skin manifestations of urticaria and angioedema. Used as self-medication for temporary relief of symptoms associated with the common cold.
Structured Indications
PharmacodynamicsClemastine is an antihistamine with anticholinergic (drying) and sedative side effects. Antihistamines competitively antagonize various physiological effects of histamine including increased capillary permeability and dilatation, the formation of edema, the "flare" and "itch" response, and gastrointestinal and respiratory smooth muscle constriction. Within the vascular tree, H1- receptor antagonists inhibit both the vasoconstrictor and vasodilator effects of histamine. Depending on the dose, H1- receptor antagonists can produce CNS stimulation or depression. Most antihistamines exhibit central and/or peripheral anticholinergic activity. Antihistamines act by competitively blocking H1- receptor sites. Antihistamines do not pharmacologically antagonize or chemically inactivate histamine, nor do they prevent the release of histamine.
Mechanism of actionClemastine is a selective histamine H1 antagonist and binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
TargetKindPharmacological actionActionsOrganismUniProt ID
Histamine H1 receptorProteinyes
antagonist
HumanP35367 details
Related Articles
AbsorptionRapidly absorbed from the gastrointestinal tract.
Volume of distributionNot Available
Protein bindingNot Available
Metabolism

Antihistamines appear to be metabolized in the liver chiefly via mono- and didemethylation and glucuronide conjugation.

Route of eliminationUrinary excretion is the major mode of elimination.
Half lifeNot Available
ClearanceNot Available
ToxicityOral LD50 in rat and mouse is 3550 mg/kg and 730 mg/kg, respectively. Antihistamine overdosage reactions may vary from central nervous system depression to stimulation. In children, stimulation predominates initially in a syndrome which may include excitement, hallucinations, ataxia, incoordination, muscle twitching, athetosis, hyperthermia, cyanosis convulsions, tremors, and hyperreflexia followed by postictal depression and cardio-respiratory arrest. Convulsions in children may be preceded by mild depression. Dry mouth, fixed dilated pupils, flushing of the face, and fever are common. In adults, CNS depression, ranging from drowsiness to coma, is more common.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
1,1,1,2 TetrafluoroethaneThe risk or severity of adverse effects can be increased when Clemastine is combined with 1,1,1,2 Tetrafluoroethane.Investigational
2,5-Dimethoxy-4-ethylamphetamine2,5-Dimethoxy-4-ethylamphetamine may decrease the sedative activities of Clemastine.Experimental, Illicit
3,4-Methylenedioxyamphetamine3,4-Methylenedioxyamphetamine may decrease the sedative activities of Clemastine.Experimental, Illicit
3,4-Methylenedioxymethamphetamine3,4-Methylenedioxymethamphetamine may decrease the sedative activities of Clemastine.Experimental, Illicit
4-Bromo-2,5-dimethoxyamphetamine4-Bromo-2,5-dimethoxyamphetamine may decrease the sedative activities of Clemastine.Experimental, Illicit
4-MethoxyamphetamineThe metabolism of 4-Methoxyamphetamine can be decreased when combined with Clemastine.Experimental, Illicit
7-NitroindazoleThe risk or severity of adverse effects can be increased when 7-Nitroindazole is combined with Clemastine.Experimental
7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE may increase the anticholinergic activities of Clemastine.Experimental
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Clemastine.Approved
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Clemastine.Approved
AcepromazineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Clemastine.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Clemastine.Approved
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Clemastine.Approved
AcetylcholineThe metabolism of Acetylcholine can be decreased when combined with Clemastine.Approved
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Clemastine.Approved
adipiplonThe risk or severity of adverse effects can be increased when adipiplon is combined with Clemastine.Investigational
AgomelatineThe risk or severity of adverse effects can be increased when Agomelatine is combined with Clemastine.Approved, Investigational
AjmalineThe metabolism of Ajmaline can be decreased when combined with Clemastine.Approved
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Clemastine.Approved, Vet Approved
AlclometasoneThe metabolism of Alclometasone can be decreased when combined with Clemastine.Approved
AlfaxaloneThe risk or severity of adverse effects can be increased when Alfaxalone is combined with Clemastine.Vet Approved
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Clemastine.Approved, Illicit
AlfuzosinThe metabolism of Alfuzosin can be decreased when combined with Clemastine.Approved, Investigational
AliskirenThe metabolism of Aliskiren can be decreased when combined with Clemastine.Approved, Investigational
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Clemastine.Approved
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Clemastine.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Clemastine.Approved
AlosetronThe metabolism of Alosetron can be decreased when combined with Clemastine.Approved, Withdrawn
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Clemastine.Experimental, Illicit
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Clemastine.Approved, Illicit, Investigational
AlprenololThe metabolism of Alprenolol can be decreased when combined with Clemastine.Approved, Withdrawn
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Clemastine.Approved, Investigational
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Clemastine.Approved
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Clemastine.Approved, Withdrawn
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Clemastine.Approved
AmiodaroneThe metabolism of Amiodarone can be decreased when combined with Clemastine.Approved, Investigational
AmisulprideThe risk or severity of adverse effects can be increased when Amisulpride is combined with Clemastine.Approved, Investigational
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Clemastine.Approved
AmlodipineThe metabolism of Amlodipine can be decreased when combined with Clemastine.Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Clemastine.Approved, Illicit
AmoxapineThe metabolism of Amoxapine can be decreased when combined with Clemastine.Approved
AmperozideThe risk or severity of adverse effects can be increased when Amperozide is combined with Clemastine.Experimental
AmphetamineThe metabolism of Amphetamine can be decreased when combined with Clemastine.Approved, Illicit
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Clemastine.Approved
AmsacrineThe metabolism of Amsacrine can be decreased when combined with Clemastine.Approved
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Clemastine.Approved
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Clemastine.Approved
ApremilastThe metabolism of Apremilast can be decreased when combined with Clemastine.Approved, Investigational
AprepitantThe metabolism of Aprepitant can be decreased when combined with Clemastine.Approved, Investigational
AprindineThe metabolism of Aprindine can be decreased when combined with Clemastine.Approved
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Clemastine.Approved, Investigational
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Clemastine.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Clemastine.Approved, Investigational
ArtemetherThe metabolism of Artemether can be decreased when combined with Clemastine.Approved
ArticaineThe risk or severity of adverse effects can be increased when Articaine is combined with Clemastine.Approved
AsenapineThe metabolism of Asenapine can be decreased when combined with Clemastine.Approved
AstemizoleThe metabolism of Astemizole can be decreased when combined with Clemastine.Approved, Withdrawn
AtazanavirThe metabolism of Atazanavir can be decreased when combined with Clemastine.Approved, Investigational
AtomoxetineThe metabolism of Atomoxetine can be decreased when combined with Clemastine.Approved
AtorvastatinThe metabolism of Atorvastatin can be decreased when combined with Clemastine.Approved
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Clemastine.Approved
AxitinibThe metabolism of Axitinib can be decreased when combined with Clemastine.Approved, Investigational
AzaperoneThe risk or severity of adverse effects can be increased when Azaperone is combined with Clemastine.Vet Approved
AzelastineClemastine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
AzelastineThe metabolism of Azelastine can be decreased when combined with Clemastine.Approved
AzithromycinThe metabolism of Azithromycin can be decreased when combined with Clemastine.Approved
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Clemastine.Approved
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Clemastine.Investigational
BarbitalThe risk or severity of adverse effects can be increased when Barbital is combined with Clemastine.Illicit
BedaquilineThe metabolism of Bedaquiline can be decreased when combined with Clemastine.Approved
BenmoxinBenmoxin may increase the anticholinergic activities of Clemastine.Withdrawn
BenperidolThe risk or severity of adverse effects can be increased when Clemastine is combined with Benperidol.Investigational
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Clemastine.Approved
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Clemastine.Approved
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Clemastine.Approved, Illicit
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Clemastine.Approved
Benzylpenicilloyl PolylysineClemastine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.Approved
BepridilThe metabolism of Bepridil can be decreased when combined with Clemastine.Approved, Withdrawn
BetahistineThe therapeutic efficacy of Betahistine can be decreased when used in combination with Clemastine.Approved
BetaxololThe metabolism of Betaxolol can be decreased when combined with Clemastine.Approved
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Clemastine.Approved, Investigational
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Clemastine.Approved
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Clemastine.Approved
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Clemastine.Approved
BoceprevirThe metabolism of Boceprevir can be decreased when combined with Clemastine.Approved
BortezomibThe metabolism of Bortezomib can be decreased when combined with Clemastine.Approved, Investigational
BosentanThe serum concentration of Bosentan can be increased when it is combined with Clemastine.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Clemastine.Approved
Brentuximab vedotinThe metabolism of Brentuximab vedotin can be decreased when combined with Clemastine.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Clemastine.Approved
BrimonidineThe risk or severity of adverse effects can be increased when Clemastine is combined with Brimonidine.Approved
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Clemastine.Approved
BrinzolamideThe metabolism of Brinzolamide can be decreased when combined with Clemastine.Approved
BromazepamThe metabolism of Bromazepam can be decreased when combined with Clemastine.Approved, Illicit
BromocriptineThe metabolism of Bromocriptine can be decreased when combined with Clemastine.Approved, Investigational
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Clemastine.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Brotizolam is combined with Clemastine.Approved, Withdrawn
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Clemastine.Approved
BudesonideThe metabolism of Budesonide can be decreased when combined with Clemastine.Approved
BufuralolThe metabolism of Bufuralol can be decreased when combined with Clemastine.Experimental, Investigational
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Clemastine.Approved, Investigational
BuprenorphineClemastine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Bupropion can be decreased when combined with Clemastine.Approved
BuspironeThe metabolism of Buspirone can be decreased when combined with Clemastine.Approved, Investigational
BusulfanThe metabolism of Busulfan can be decreased when combined with Clemastine.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Clemastine.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Butacaine is combined with Clemastine.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Butalbital is combined with Clemastine.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Butamben is combined with Clemastine.Approved
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Clemastine.Approved, Illicit
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Clemastine.Approved, Illicit, Vet Approved
CabazitaxelThe metabolism of Cabazitaxel can be decreased when combined with Clemastine.Approved
CabergolineThe metabolism of Cabergoline can be decreased when combined with Clemastine.Approved
CabozantinibThe metabolism of Cabozantinib can be decreased when combined with Clemastine.Approved
CaffeineThe metabolism of Caffeine can be decreased when combined with Clemastine.Approved
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Clemastine.Approved, Nutraceutical
CanagliflozinThe metabolism of Canagliflozin can be decreased when combined with Clemastine.Approved
CaptoprilThe metabolism of Captopril can be decreased when combined with Clemastine.Approved
CarbamazepineThe metabolism of Carbamazepine can be decreased when combined with Clemastine.Approved, Investigational
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Clemastine.Approved
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Clemastine.Illicit, Vet Approved
CariprazineThe metabolism of Cariprazine can be decreased when combined with Clemastine.Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Clemastine is combined with Carisoprodol.Approved
CaroxazoneCaroxazone may increase the anticholinergic activities of Clemastine.Withdrawn
CarteololThe metabolism of Carteolol can be decreased when combined with Clemastine.Approved
CarvedilolThe metabolism of Carvedilol can be decreased when combined with Clemastine.Approved, Investigational
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Clemastine.Approved, Investigational
CeliprololThe metabolism of Celiprolol can be decreased when combined with Clemastine.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be decreased when combined with Clemastine.Approved, Vet Approved
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Clemastine.Withdrawn
CetirizineThe risk or severity of adverse effects can be increased when Clemastine is combined with Cetirizine.Approved
CevimelineThe metabolism of Cevimeline can be decreased when combined with Clemastine.Approved
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Clemastine.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Clemastine.Approved, Illicit, Vet Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Clemastine.Approved, Illicit
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Clemastine.Approved, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Clemastine.Approved
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Clemastine.Approved, Vet Approved
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Clemastine.Approved
ChlorphentermineChlorphentermine may decrease the sedative activities of Clemastine.Illicit, Withdrawn
ChlorpromazineThe metabolism of Chlorpromazine can be decreased when combined with Clemastine.Approved, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Clemastine.Approved, Withdrawn
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Clemastine.Approved
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Clemastine.Approved, Nutraceutical
CiclesonideThe metabolism of Ciclesonide can be decreased when combined with Clemastine.Approved, Investigational
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Clemastine.Approved
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Clemastine.Approved
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Clemastine.Approved, Vet Approved
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Clemastine.Approved
CisaprideThe metabolism of Cisapride can be decreased when combined with Clemastine.Approved, Investigational, Withdrawn
CitalopramThe metabolism of Citalopram can be decreased when combined with Clemastine.Approved
ClarithromycinThe metabolism of Clarithromycin can be decreased when combined with Clemastine.Approved
ClevidipineThe metabolism of Clevidipine can be decreased when combined with Clemastine.Approved
ClidiniumThe risk or severity of adverse effects can be increased when Clemastine is combined with Clidinium.Approved
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Clemastine.Approved, Vet Approved
ClobazamThe metabolism of Clobazam can be decreased when combined with Clemastine.Approved, Illicit
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Clemastine.Approved, Investigational
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Clemastine.Approved
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Clemastine.Investigational
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Clemastine.Approved, Vet Approved
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Clemastine.Approved, Illicit
ClonidineThe metabolism of Clonidine can be decreased when combined with Clemastine.Approved
ClopidogrelThe metabolism of Clopidogrel can be decreased when combined with Clemastine.Approved, Nutraceutical
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Clemastine.Approved, Illicit
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Clemastine.Approved, Illicit
ClozapineThe metabolism of Clozapine can be decreased when combined with Clemastine.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Clemastine.Approved
CocaineThe metabolism of Cocaine can be decreased when combined with Clemastine.Approved, Illicit
CodeineThe therapeutic efficacy of Codeine can be decreased when used in combination with Clemastine.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Clemastine.Approved
ConivaptanThe metabolism of Conivaptan can be decreased when combined with Clemastine.Approved, Investigational
Conjugated Equine EstrogensThe metabolism of Conjugated Equine Estrogens can be decreased when combined with Clemastine.Approved
Cortisone acetateThe metabolism of Cortisone acetate can be decreased when combined with Clemastine.Approved
CrizotinibThe metabolism of Crizotinib can be decreased when combined with Clemastine.Approved
CyclizineThe risk or severity of adverse effects can be increased when Clemastine is combined with Cyclizine.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Clemastine.Approved
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Clemastine.Approved, Investigational
CyclosporineThe metabolism of Cyclosporine can be decreased when combined with Clemastine.Approved, Investigational, Vet Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Clemastine is combined with Cyproheptadine.Approved
CytarabineThe metabolism of Cytarabine can be decreased when combined with Clemastine.Approved, Investigational
DabrafenibThe metabolism of Dabrafenib can be decreased when combined with Clemastine.Approved
DaclatasvirThe metabolism of Daclatasvir can be decreased when combined with Clemastine.Approved
DantroleneThe metabolism of Dantrolene can be decreased when combined with Clemastine.Approved
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Clemastine.Approved
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Clemastine.Approved
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Clemastine.Investigational
DapsoneThe metabolism of Dapsone can be decreased when combined with Clemastine.Approved, Investigational
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Clemastine.Approved, Investigational
DarunavirThe metabolism of Darunavir can be decreased when combined with Clemastine.Approved
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Clemastine.Approved
DasatinibThe metabolism of Dasatinib can be decreased when combined with Clemastine.Approved, Investigational
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Clemastine.Approved
DebrisoquinThe metabolism of Debrisoquin can be decreased when combined with Clemastine.Approved
DelavirdineThe metabolism of Delavirdine can be decreased when combined with Clemastine.Approved
deramciclaneThe risk or severity of adverse effects can be increased when deramciclane is combined with Clemastine.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Clemastine.Approved
DesipramineThe metabolism of Desipramine can be decreased when combined with Clemastine.Approved
DesloratadineThe risk or severity of adverse effects can be increased when Clemastine is combined with Desloratadine.Approved, Investigational
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Clemastine.Approved
DetomidineThe risk or severity of adverse effects can be increased when Detomidine is combined with Clemastine.Vet Approved
DexamethasoneThe metabolism of Dexamethasone can be decreased when combined with Clemastine.Approved, Investigational, Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Clemastine is combined with Dexbrompheniramine.Approved
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Clemastine.Approved, Illicit, Withdrawn
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Clemastine.Approved, Vet Approved
DexmethylphenidateThe metabolism of Dexmethylphenidate can be decreased when combined with Clemastine.Approved
DextroamphetamineThe metabolism of Dextroamphetamine can be decreased when combined with Clemastine.Approved, Illicit
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Clemastine.Approved
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Clemastine.Experimental, Illicit
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Clemastine.Approved, Illicit, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Clemastine.Approved
DiazepamThe metabolism of Diazepam can be decreased when combined with Clemastine.Approved, Illicit, Vet Approved
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Clemastine.Approved, Vet Approved
DiethylpropionDiethylpropion may decrease the sedative activities of Clemastine.Approved, Illicit
DifenoxinThe risk or severity of adverse effects can be increased when Clemastine is combined with Difenoxin.Approved, Illicit
DigitoxinThe metabolism of Digitoxin can be decreased when combined with Clemastine.Approved
DigoxinThe metabolism of Digoxin can be decreased when combined with Clemastine.Approved
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Clemastine.Approved, Illicit
DihydroergotamineThe metabolism of Dihydroergotamine can be decreased when combined with Clemastine.Approved
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Clemastine.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Dihydromorphine is combined with Clemastine.Experimental, Illicit
DiltiazemThe metabolism of Diltiazem can be decreased when combined with Clemastine.Approved
DimenhydrinateThe risk or severity of adverse effects can be increased when Clemastine is combined with Dimenhydrinate.Approved
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Clemastine.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Clemastine.Approved, Illicit
DisopyramideThe metabolism of Disopyramide can be decreased when combined with Clemastine.Approved
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Clemastine.Approved
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Clemastine.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Clemastine.Approved
DolasetronThe metabolism of Dolasetron can be decreased when combined with Clemastine.Approved
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Clemastine.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be decreased when combined with Clemastine.Approved
DopamineThe metabolism of Dopamine can be decreased when combined with Clemastine.Approved
DoramectinThe risk or severity of adverse effects can be increased when Doramectin is combined with Clemastine.Vet Approved
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Clemastine.Approved
DoxazosinThe metabolism of Doxazosin can be decreased when combined with Clemastine.Approved
DoxepinThe metabolism of Doxepin can be decreased when combined with Clemastine.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Clemastine.Approved, Investigational
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Clemastine.Approved, Investigational
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Clemastine.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when DPDPE is combined with Clemastine.Investigational
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Clemastine.Approved, Illicit
DronedaroneThe metabolism of Dronedarone can be decreased when combined with Clemastine.Approved
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Clemastine.Approved, Vet Approved
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Clemastine.Experimental, Illicit
DuloxetineThe metabolism of Duloxetine can be decreased when combined with Clemastine.Approved
DutasterideThe metabolism of Dutasteride can be decreased when combined with Clemastine.Approved, Investigational
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Clemastine.Approved
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Clemastine.Experimental, Illicit
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when ECGONINE METHYL ESTER is combined with Clemastine.Experimental
EcopipamThe risk or severity of adverse effects can be increased when Clemastine is combined with Ecopipam.Investigational
EfavirenzThe metabolism of Efavirenz can be decreased when combined with Clemastine.Approved, Investigational
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Clemastine.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Clemastine.Approved
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Clemastine.Approved
EnalaprilThe metabolism of Enalapril can be decreased when combined with Clemastine.Approved, Vet Approved
EncainideThe metabolism of Encainide can be decreased when combined with Clemastine.Approved, Withdrawn
EnclomipheneThe metabolism of Enclomiphene can be decreased when combined with Clemastine.Investigational
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Clemastine.Approved, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Clemastine is combined with Entacapone.Approved, Investigational
EnzalutamideThe metabolism of Enzalutamide can be decreased when combined with Clemastine.Approved
EpinastineThe metabolism of Epinastine can be decreased when combined with Clemastine.Approved, Investigational
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Clemastine.Approved
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Clemastine.Approved, Nutraceutical
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be decreased when combined with Clemastine.Approved
ErgonovineThe metabolism of Ergonovine can be decreased when combined with Clemastine.Approved
ErgotamineThe metabolism of Ergotamine can be decreased when combined with Clemastine.Approved
ErlotinibThe metabolism of Erlotinib can be decreased when combined with Clemastine.Approved, Investigational
ErythromycinThe metabolism of Erythromycin can be decreased when combined with Clemastine.Approved, Vet Approved
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Clemastine.Approved, Investigational
EsmirtazapineThe metabolism of Esmirtazapine can be decreased when combined with Clemastine.Investigational
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Clemastine.Approved, Investigational
EstazolamThe metabolism of Estazolam can be decreased when combined with Clemastine.Approved, Illicit
EstradiolThe metabolism of Estradiol can be decreased when combined with Clemastine.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Clemastine.Approved
EstramustineThe metabolism of Estramustine can be decreased when combined with Clemastine.Approved
EstroneThe metabolism of Estrone can be decreased when combined with Clemastine.Approved
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Clemastine.Approved
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Clemastine.Approved
EthanolClemastine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Clemastine.Approved, Illicit, Withdrawn
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be decreased when combined with Clemastine.Approved
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Clemastine.Approved
EthotoinThe risk or severity of adverse effects can be increased when Clemastine is combined with Ethotoin.Approved
Ethyl carbamateThe risk or severity of adverse effects can be increased when Ethyl carbamate is combined with Clemastine.Withdrawn
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Clemastine.Approved, Illicit
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Clemastine.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Etidocaine is combined with Clemastine.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Clemastine.Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Etizolam is combined with Clemastine.Approved
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Clemastine.Approved
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Clemastine.Approved, Investigational
EtoperidoneThe risk or severity of adverse effects can be increased when Clemastine is combined with Etoperidone.Approved
EtoposideThe metabolism of Etoposide can be decreased when combined with Clemastine.Approved
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Clemastine.Approved, Investigational
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Clemastine.Illicit, Vet Approved
EtravirineThe metabolism of Etravirine can be decreased when combined with Clemastine.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Clemastine.Approved
ExemestaneThe metabolism of Exemestane can be decreased when combined with Clemastine.Approved, Investigational
EzogabineThe risk or severity of adverse effects can be increased when Clemastine is combined with Ezogabine.Approved
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Clemastine.Approved
FelbamateThe metabolism of Felbamate can be decreased when combined with Clemastine.Approved
FelodipineThe metabolism of Felodipine can be decreased when combined with Clemastine.Approved, Investigational
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Clemastine.Approved, Illicit, Withdrawn
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Clemastine.Approved
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Clemastine.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Clemastine.Approved
FexofenadineThe risk or severity of adverse effects can be increased when Clemastine is combined with Fexofenadine.Approved
FinasterideThe metabolism of Finasteride can be decreased when combined with Clemastine.Approved
FingolimodThe metabolism of Fingolimod can be decreased when combined with Clemastine.Approved, Investigational
FlecainideThe metabolism of Flecainide can be decreased when combined with Clemastine.Approved, Withdrawn
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Clemastine.Approved
FludiazepamThe risk or severity of adverse effects can be increased when Fludiazepam is combined with Clemastine.Approved, Illicit
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Clemastine.Approved
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Clemastine.Approved, Investigational
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Clemastine.Approved, Illicit
FluorometholoneThe metabolism of Fluorometholone can be decreased when combined with Clemastine.Approved
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Clemastine.Approved, Vet Approved
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Clemastine.Approved, Withdrawn
FluphenazineThe metabolism of Fluphenazine can be decreased when combined with Clemastine.Approved
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Clemastine.Approved, Illicit
FluspirileneThe risk or severity of adverse effects can be increased when Fluspirilene is combined with Clemastine.Approved
FlutamideThe metabolism of Flutamide can be decreased when combined with Clemastine.Approved
Fluticasone furoateThe metabolism of Fluticasone furoate can be decreased when combined with Clemastine.Approved
Fluticasone PropionateThe metabolism of Fluticasone Propionate can be decreased when combined with Clemastine.Approved
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Clemastine.Approved
FluvoxamineThe metabolism of Fluvoxamine can be decreased when combined with Clemastine.Approved, Investigational
FormoterolThe metabolism of Formoterol can be decreased when combined with Clemastine.Approved, Investigational
FosamprenavirThe metabolism of Fosamprenavir can be decreased when combined with Clemastine.Approved
FosphenytoinThe risk or severity of adverse effects can be increased when Clemastine is combined with Fosphenytoin.Approved
FospropofolThe risk or severity of adverse effects can be increased when Fospropofol is combined with Clemastine.Approved, Illicit
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Clemastine.Approved, Investigational
FurazolidoneFurazolidone may increase the anticholinergic activities of Clemastine.Approved, Vet Approved
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Clemastine.Approved, Investigational
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Clemastine is combined with gabapentin enacarbil.Approved
GalantamineThe metabolism of Galantamine can be decreased when combined with Clemastine.Approved
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Clemastine.Approved, Illicit
GefitinibThe metabolism of Gefitinib can be decreased when combined with Clemastine.Approved, Investigational
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Clemastine.Approved
GepironeThe risk or severity of adverse effects can be increased when Clemastine is combined with Gepirone.Investigational
GlipizideThe metabolism of Glipizide can be decreased when combined with Clemastine.Approved
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Clemastine.Approved, Illicit
GlyburideThe metabolism of Glyburide can be decreased when combined with Clemastine.Approved
GranisetronThe metabolism of Granisetron can be decreased when combined with Clemastine.Approved, Investigational
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Clemastine.Withdrawn
GuanfacineThe metabolism of Guanfacine can be decreased when combined with Clemastine.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Clemastine.Approved, Illicit, Withdrawn
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Clemastine.Approved
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Clemastine.Approved
HalothaneThe metabolism of Halothane can be decreased when combined with Clemastine.Approved, Vet Approved
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Clemastine.Approved, Illicit
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Clemastine.Approved
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Clemastine.Approved
HyaluronidaseThe therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Clemastine.Approved, Investigational
HydracarbazineHydracarbazine may increase the anticholinergic activities of Clemastine.Approved
HydrocodoneClemastine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydrocortisoneThe metabolism of Hydrocortisone can be decreased when combined with Clemastine.Approved, Vet Approved
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Clemastine.Approved, Illicit
Hydroxyamphetamine hydrobromideHydroxyamphetamine hydrobromide may decrease the sedative activities of Clemastine.Approved
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Clemastine.Approved
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Clemastine.Approved
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Clemastine.Approved
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Clemastine.Approved
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Clemastine resulting in a loss in efficacy.Approved
IloperidoneThe metabolism of Iloperidone can be decreased when combined with Clemastine.Approved
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Clemastine.Approved
ImipramineThe metabolism of Imipramine can be decreased when combined with Clemastine.Approved
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Clemastine.Approved, Investigational
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Clemastine.Approved
IndalpineThe risk or severity of adverse effects can be increased when Clemastine is combined with Indalpine.Investigational, Withdrawn
IndapamideThe metabolism of Indapamide can be decreased when combined with Clemastine.Approved
IndinavirThe metabolism of Indinavir can be decreased when combined with Clemastine.Approved
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Clemastine.Approved
IproclozideIproclozide may increase the anticholinergic activities of Clemastine.Withdrawn
IproniazidIproniazid may increase the anticholinergic activities of Clemastine.Withdrawn
IrinotecanThe metabolism of Irinotecan can be decreased when combined with Clemastine.Approved, Investigational
IsavuconazoniumThe metabolism of Isavuconazonium can be decreased when combined with Clemastine.Approved, Investigational
IsocarboxazidIsocarboxazid may increase the anticholinergic activities of Clemastine.Approved
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Clemastine.Approved, Vet Approved
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Clemastine.Approved
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Clemastine.Approved
IsradipineThe metabolism of Isradipine can be decreased when combined with Clemastine.Approved
ItraconazoleThe metabolism of Itraconazole can be decreased when combined with Clemastine.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Clemastine.Approved
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Clemastine.Approved
IvermectinThe metabolism of Ivermectin can be decreased when combined with Clemastine.Approved, Vet Approved
IxabepiloneThe metabolism of Ixabepilone can be decreased when combined with Clemastine.Approved, Investigational
IxazomibThe metabolism of Ixazomib can be decreased when combined with Clemastine.Approved
KetamineThe metabolism of Ketamine can be decreased when combined with Clemastine.Approved, Vet Approved
KetazolamThe metabolism of Ketazolam can be decreased when combined with Clemastine.Approved
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Clemastine.Approved
KetoconazoleThe metabolism of Ketoconazole can be decreased when combined with Clemastine.Approved, Investigational
LabetalolThe metabolism of Labetalol can be decreased when combined with Clemastine.Approved
LamotrigineThe risk or severity of adverse effects can be increased when Clemastine is combined with Lamotrigine.Approved, Investigational
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Clemastine.Approved, Investigational
LapatinibThe metabolism of Lapatinib can be decreased when combined with Clemastine.Approved, Investigational
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Clemastine.Investigational
LenvatinibThe metabolism of Lenvatinib can be decreased when combined with Clemastine.Approved
LercanidipineThe metabolism of Lercanidipine can be decreased when combined with Clemastine.Approved, Investigational
LetrozoleThe metabolism of Letrozole can be decreased when combined with Clemastine.Approved, Investigational
LevetiracetamThe risk or severity of adverse effects can be increased when Clemastine is combined with Levetiracetam.Approved, Investigational
LevobupivacaineThe metabolism of Levobupivacaine can be decreased when combined with Clemastine.Approved
LevocabastineThe risk or severity of adverse effects can be increased when Clemastine is combined with Levocabastine.Approved
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Clemastine.Approved
LevodopaThe metabolism of Levodopa can be decreased when combined with Clemastine.Approved
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Clemastine.Approved
LevomilnacipranThe metabolism of Levomilnacipran can be decreased when combined with Clemastine.Approved
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Clemastine.Approved, Investigational
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Clemastine.Approved
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Clemastine.Approved
LidocaineThe metabolism of Lidocaine can be decreased when combined with Clemastine.Approved, Vet Approved
LisdexamfetamineLisdexamfetamine may decrease the sedative activities of Clemastine.Approved, Investigational
LisurideThe metabolism of Lisuride can be decreased when combined with Clemastine.Approved
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with Clemastine.Approved
LofentanilThe risk or severity of adverse effects can be increased when Lofentanil is combined with Clemastine.Illicit
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Clemastine.Approved
LomustineThe metabolism of Lomustine can be decreased when combined with Clemastine.Approved
LoperamideThe metabolism of Loperamide can be decreased when combined with Clemastine.Approved
LopinavirThe metabolism of Lopinavir can be decreased when combined with Clemastine.Approved
LoratadineThe metabolism of Loratadine can be decreased when combined with Clemastine.Approved
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Clemastine.Approved
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Clemastine.Approved
LosartanThe metabolism of Losartan can be decreased when combined with Clemastine.Approved
LovastatinThe metabolism of Lovastatin can be decreased when combined with Clemastine.Approved, Investigational
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Clemastine.Approved
Lu AA21004The risk or severity of adverse effects can be increased when Lu AA21004 is combined with Clemastine.Investigational
LumefantrineThe metabolism of Lumefantrine can be decreased when combined with Clemastine.Approved
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Clemastine.Approved
MacitentanThe metabolism of Macitentan can be decreased when combined with Clemastine.Approved
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Clemastine.Approved, Vet Approved
MaprotilineThe metabolism of Maprotiline can be decreased when combined with Clemastine.Approved
MaravirocThe metabolism of Maraviroc can be decreased when combined with Clemastine.Approved, Investigational
MebanazineMebanazine may increase the anticholinergic activities of Clemastine.Withdrawn
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Clemastine.Approved, Vet Approved
MeclizineThe risk or severity of adverse effects can be increased when Clemastine is combined with Meclizine.Approved
MedetomidineThe risk or severity of adverse effects can be increased when Medetomidine is combined with Clemastine.Vet Approved
Medroxyprogesterone acetateThe metabolism of Medroxyprogesterone acetate can be decreased when combined with Clemastine.Approved, Investigational
MefloquineThe metabolism of Mefloquine can be decreased when combined with Clemastine.Approved
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Clemastine.Approved, Nutraceutical, Vet Approved
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Clemastine.Approved, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Melperone is combined with Clemastine.Approved
MephedroneMephedrone may decrease the sedative activities of Clemastine.Investigational
MephentermineMephentermine may decrease the sedative activities of Clemastine.Approved
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Clemastine.Investigational, Withdrawn
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Clemastine.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Clemastine.Approved, Illicit
MequitazineThe metabolism of Mequitazine can be decreased when combined with Clemastine.Approved
MesoridazineThe metabolism of Mesoridazine can be decreased when combined with Clemastine.Approved
MetaxaloneThe risk or severity of adverse effects can be increased when Clemastine is combined with Metaxalone.Approved
MethadoneThe metabolism of Methadone can be decreased when combined with Clemastine.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Clemastine.Approved, Illicit
MethamphetamineThe metabolism of Methamphetamine can be decreased when combined with Clemastine.Approved, Illicit
MethapyrileneThe risk or severity of adverse effects can be increased when Methapyrilene is combined with Clemastine.Withdrawn
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Clemastine.Illicit, Withdrawn
MethocarbamolThe risk or severity of adverse effects can be increased when Clemastine is combined with Methocarbamol.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Clemastine.Approved
MethotrimeprazineClemastine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Clemastine.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Clemastine.Approved, Vet Approved
MethsuximideThe risk or severity of adverse effects can be increased when Clemastine is combined with Methsuximide.Approved
Methylene blueMethylene blue may increase the anticholinergic activities of Clemastine.Investigational
MethylphenidateThe metabolism of Methylphenidate can be decreased when combined with Clemastine.Approved, Investigational
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Clemastine.Approved
MethylprednisoloneThe metabolism of Methylprednisolone can be decreased when combined with Clemastine.Approved, Vet Approved
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Clemastine.Approved
MethyprylonThe metabolism of Methyprylon can be decreased when combined with Clemastine.Approved, Illicit, Withdrawn
MetoclopramideThe metabolism of Metoclopramide can be decreased when combined with Clemastine.Approved, Investigational
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Clemastine.Approved, Investigational
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Clemastine.Approved
MetyrosineClemastine may increase the sedative activities of Metyrosine.Approved
MexiletineThe metabolism of Mexiletine can be decreased when combined with Clemastine.Approved
MianserinThe metabolism of Mianserin can be decreased when combined with Clemastine.Approved
MibefradilThe metabolism of Mibefradil can be decreased when combined with Clemastine.Withdrawn
MiconazoleThe metabolism of Miconazole can be decreased when combined with Clemastine.Approved, Investigational, Vet Approved
MidazolamThe metabolism of Midazolam can be decreased when combined with Clemastine.Approved, Illicit
MifepristoneThe metabolism of Mifepristone can be decreased when combined with Clemastine.Approved, Investigational
MilnacipranThe risk or severity of adverse effects can be increased when Clemastine is combined with Milnacipran.Approved
MinaprineMinaprine may increase the anticholinergic activities of Clemastine.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Clemastine.Approved, Investigational
MirabegronThe metabolism of Mirabegron can be decreased when combined with Clemastine.Approved
MirtazapineClemastine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MMDAMMDA may decrease the sedative activities of Clemastine.Experimental, Illicit
MoclobemideMoclobemide may increase the anticholinergic activities of Clemastine.Approved
ModafinilThe metabolism of Modafinil can be decreased when combined with Clemastine.Approved, Investigational
MolindoneThe risk or severity of adverse effects can be increased when Molindone is combined with Clemastine.Approved
MontelukastThe metabolism of Montelukast can be decreased when combined with Clemastine.Approved
MorphineThe metabolism of Morphine can be decreased when combined with Clemastine.Approved, Investigational
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Clemastine.Approved, Investigational
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Clemastine.Approved, Investigational
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Clemastine.Approved
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Clemastine.Approved
NaloxoneThe metabolism of Naloxone can be decreased when combined with Clemastine.Approved, Vet Approved
NateglinideThe metabolism of Nateglinide can be decreased when combined with Clemastine.Approved, Investigational
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Clemastine.Approved, Investigational
NefazodoneThe metabolism of Nefazodone can be decreased when combined with Clemastine.Approved, Withdrawn
NelfinavirThe metabolism of Nelfinavir can be decreased when combined with Clemastine.Approved
NetupitantThe metabolism of Netupitant can be decreased when combined with Clemastine.Approved
NevirapineThe metabolism of Nevirapine can be decreased when combined with Clemastine.Approved
NialamideNialamide may increase the anticholinergic activities of Clemastine.Withdrawn
NicardipineThe metabolism of Nicardipine can be decreased when combined with Clemastine.Approved
NicergolineThe metabolism of Nicergoline can be decreased when combined with Clemastine.Approved
NicotineThe metabolism of Nicotine can be decreased when combined with Clemastine.Approved
NifedipineThe metabolism of Nifedipine can be decreased when combined with Clemastine.Approved
NilotinibThe metabolism of Nilotinib can be decreased when combined with Clemastine.Approved, Investigational
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Clemastine.Approved
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Clemastine.Approved
NisoldipineThe metabolism of Nisoldipine can be decreased when combined with Clemastine.Approved
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Clemastine.Approved
NitrendipineThe metabolism of Nitrendipine can be decreased when combined with Clemastine.Approved
NitrofuralThe metabolism of Nitrofural can be decreased when combined with Clemastine.Approved, Vet Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Clemastine.Approved, Vet Approved
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Clemastine.Approved
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Clemastine.Approved
NormethadoneThe risk or severity of adverse effects can be increased when Normethadone is combined with Clemastine.Approved, Illicit
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Clemastine.Approved
OctamoxinOctamoxin may increase the anticholinergic activities of Clemastine.Withdrawn
OlanzapineThe metabolism of Olanzapine can be decreased when combined with Clemastine.Approved, Investigational
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Clemastine.Approved
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Clemastine.Approved
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Clemastine.Approved, Investigational, Vet Approved
OndansetronThe metabolism of Ondansetron can be decreased when combined with Clemastine.Approved
OpiumThe risk or severity of adverse effects can be increased when Opium is combined with Clemastine.Approved, Illicit
OrphenadrineClemastine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Osanetant is combined with Clemastine.Investigational
OspemifeneThe metabolism of Ospemifene can be decreased when combined with Clemastine.Approved
OxazepamThe metabolism of Oxazepam can be decreased when combined with Clemastine.Approved
OxetacaineThe risk or severity of adverse effects can be increased when Clemastine is combined with Oxetacaine.Investigational
OxprenololThe risk or severity of adverse effects can be increased when Oxprenolol is combined with Clemastine.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Clemastine.Approved
OxybutyninThe metabolism of Oxybutynin can be decreased when combined with Clemastine.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Clemastine is combined with Oxycodone.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Clemastine.Approved, Investigational, Vet Approved
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Clemastine.Approved, Vet Approved
PalbociclibThe metabolism of Palbociclib can be decreased when combined with Clemastine.Approved
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Clemastine.Approved
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Clemastine.Approved, Investigational
PanobinostatThe metabolism of Panobinostat can be decreased when combined with Clemastine.Approved, Investigational
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Clemastine.Approved
ParaldehydeClemastine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Clemastine.Approved
ParamethasoneThe metabolism of Paramethasone can be decreased when combined with Clemastine.Approved
ParecoxibThe metabolism of Parecoxib can be decreased when combined with Clemastine.Approved
PargylinePargyline may increase the anticholinergic activities of Clemastine.Approved
ParicalcitolThe metabolism of Paricalcitol can be decreased when combined with Clemastine.Approved, Investigational
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Clemastine.Approved
ParoxetineThe metabolism of Paroxetine can be decreased when combined with Clemastine.Approved, Investigational
PazopanibThe metabolism of Pazopanib can be decreased when combined with Clemastine.Approved
PentamidineThe metabolism of Pentamidine can be decreased when combined with Clemastine.Approved
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Clemastine.Approved, Vet Approved
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Clemastine.Approved, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Clemastine.Approved
PerazineThe risk or severity of adverse effects can be increased when Clemastine is combined with Perazine.Investigational
PergolideThe metabolism of Pergolide can be decreased when combined with Clemastine.Approved, Vet Approved, Withdrawn
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Clemastine.Approved
PermethrinThe metabolism of Permethrin can be decreased when combined with Clemastine.Approved, Investigational
PerospironeThe risk or severity of adverse effects can be increased when Perospirone is combined with Clemastine.Approved
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Clemastine.Approved
PethidineThe metabolism of Pethidine can be decreased when combined with Clemastine.Approved
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Clemastine.Withdrawn
PhenelzinePhenelzine may increase the anticholinergic activities of Clemastine.Approved
PhenforminThe metabolism of Phenformin can be decreased when combined with Clemastine.Approved, Withdrawn
PheniprazinePheniprazine may increase the anticholinergic activities of Clemastine.Withdrawn
PhenobarbitalThe risk or severity of adverse effects can be increased when Phenobarbital is combined with Clemastine.Approved
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Clemastine.Approved
PhenoxyethanolThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Clemastine.Approved
PhenoxypropazinePhenoxypropazine may increase the anticholinergic activities of Clemastine.Withdrawn
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Clemastine.Approved
PhenterminePhentermine may decrease the sedative activities of Clemastine.Approved, Illicit
PhenytoinThe metabolism of Phenytoin can be decreased when combined with Clemastine.Approved, Vet Approved
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Clemastine.Approved
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Clemastine.Approved, Investigational
PimozideThe serum concentration of Pimozide can be increased when it is combined with Clemastine.Approved
PinacidilThe metabolism of Pinacidil can be decreased when combined with Clemastine.Withdrawn
PindololThe metabolism of Pindolol can be decreased when combined with Clemastine.Approved
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Clemastine.Approved, Investigational
PipamperoneThe risk or severity of adverse effects can be increased when Pipamperone is combined with Clemastine.Approved
PiperazineThe metabolism of Piperazine can be decreased when combined with Clemastine.Approved, Vet Approved
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Clemastine.Approved
PiritramideThe risk or severity of adverse effects can be increased when Clemastine is combined with Piritramide.Investigational
PirlindolePirlindole may increase the anticholinergic activities of Clemastine.Approved
PivhydrazinePivhydrazine may increase the anticholinergic activities of Clemastine.Withdrawn
PizotifenThe risk or severity of adverse effects can be increased when Clemastine is combined with Pizotifen.Approved
PodofiloxThe metabolism of Podofilox can be decreased when combined with Clemastine.Approved
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Clemastine.Approved
PonatinibThe metabolism of Ponatinib can be decreased when combined with Clemastine.Approved
PosaconazoleThe metabolism of Posaconazole can be decreased when combined with Clemastine.Approved, Investigational, Vet Approved
PramipexoleClemastine may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Pramocaine is combined with Clemastine.Approved
PrasteroneThe metabolism of Prasterone can be decreased when combined with Clemastine.Approved, Nutraceutical
PrasugrelThe metabolism of Prasugrel can be decreased when combined with Clemastine.Approved
PravastatinThe metabolism of Pravastatin can be decreased when combined with Clemastine.Approved
PrazepamThe metabolism of Prazepam can be decreased when combined with Clemastine.Approved, Illicit
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Clemastine.Approved, Vet Approved
PrednisoloneThe metabolism of Prednisolone can be decreased when combined with Clemastine.Approved, Vet Approved
PrednisoneThe metabolism of Prednisone can be decreased when combined with Clemastine.Approved, Vet Approved
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Clemastine.Approved, Illicit, Investigational
PregnanoloneThe risk or severity of adverse effects can be increased when Clemastine is combined with Pregnanolone.Investigational
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Clemastine.Approved
PrimaquineThe metabolism of Primaquine can be decreased when combined with Clemastine.Approved
PrimidoneThe risk or severity of adverse effects can be increased when Clemastine is combined with Primidone.Approved, Vet Approved
ProcainamideThe metabolism of Procainamide can be decreased when combined with Clemastine.Approved
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Clemastine.Approved, Investigational, Vet Approved
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Clemastine.Approved, Vet Approved
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Clemastine.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be decreased when combined with Clemastine.Approved
PromazineThe metabolism of Promazine can be decreased when combined with Clemastine.Approved, Vet Approved
PromethazineThe metabolism of Promethazine can be decreased when combined with Clemastine.Approved
PropafenoneThe serum concentration of Clemastine can be increased when it is combined with Propafenone.Approved
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Clemastine.Approved, Vet Approved
PropofolThe metabolism of Propofol can be decreased when combined with Clemastine.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Clemastine.Approved
PropranololThe metabolism of Propranolol can be decreased when combined with Clemastine.Approved, Investigational
ProtriptylineThe metabolism of Protriptyline can be decreased when combined with Clemastine.Approved
PSD502The risk or severity of adverse effects can be increased when PSD502 is combined with Clemastine.Investigational
PseudoephedrineThe metabolism of Pseudoephedrine can be decreased when combined with Clemastine.Approved
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Clemastine.Approved
QuazepamThe metabolism of Quazepam can be decreased when combined with Clemastine.Approved, Illicit
QuetiapineThe metabolism of Quetiapine can be decreased when combined with Clemastine.Approved
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Clemastine.Approved
QuinidineThe metabolism of Quinidine can be decreased when combined with Clemastine.Approved
QuinineThe metabolism of Quinine can be decreased when combined with Clemastine.Approved
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Clemastine.Approved, Investigational
RacloprideThe risk or severity of adverse effects can be increased when Clemastine is combined with Raclopride.Investigational
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Clemastine.Approved, Investigational
RamelteonThe metabolism of Ramelteon can be decreased when combined with Clemastine.Approved, Investigational
RanitidineThe metabolism of Ranitidine can be decreased when combined with Clemastine.Approved
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Clemastine.Approved, Investigational
RasagilineRasagiline may increase the anticholinergic activities of Clemastine.Approved
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Clemastine.Approved, Investigational
RegorafenibThe metabolism of Regorafenib can be decreased when combined with Clemastine.Approved
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Clemastine.Approved
RemoxiprideThe metabolism of Remoxipride can be decreased when combined with Clemastine.Approved, Withdrawn
RepaglinideThe metabolism of Repaglinide can be decreased when combined with Clemastine.Approved, Investigational
repinotanThe metabolism of repinotan can be decreased when combined with Clemastine.Investigational
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Clemastine.Approved
RetapamulinThe metabolism of Retapamulin can be decreased when combined with Clemastine.Approved
RifabutinThe metabolism of Rifabutin can be decreased when combined with Clemastine.Approved
RifampicinThe metabolism of Rifampicin can be decreased when combined with Clemastine.Approved
RilpivirineThe metabolism of Rilpivirine can be decreased when combined with Clemastine.Approved
RimonabantThe metabolism of Rimonabant can be decreased when combined with Clemastine.Approved, Investigational
RiociguatThe metabolism of Riociguat can be decreased when combined with Clemastine.Approved
RisperidoneThe metabolism of Risperidone can be decreased when combined with Clemastine.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Clemastine is combined with Ritanserin.Investigational
RitobegronRitobegron may decrease the sedative activities of Clemastine.Investigational
RitonavirThe metabolism of Ritonavir can be decreased when combined with Clemastine.Approved, Investigational
RivaroxabanThe metabolism of Rivaroxaban can be decreased when combined with Clemastine.Approved
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Clemastine.Investigational, Withdrawn
RolapitantThe metabolism of Rolapitant can be decreased when combined with Clemastine.Approved
RomidepsinThe metabolism of Romidepsin can be decreased when combined with Clemastine.Approved, Investigational
RomifidineThe risk or severity of adverse effects can be increased when Romifidine is combined with Clemastine.Vet Approved
RopiniroleClemastine may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Clemastine.Approved
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Clemastine.Approved
RotigotineClemastine may increase the sedative activities of Rotigotine.Approved
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Clemastine.Approved, Withdrawn
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Clemastine.Approved
RuxolitinibThe metabolism of Ruxolitinib can be decreased when combined with Clemastine.Approved
S-EthylisothioureaThe risk or severity of adverse effects can be increased when S-Ethylisothiourea is combined with Clemastine.Experimental
SafrazineSafrazine may increase the anticholinergic activities of Clemastine.Withdrawn
Sage 547The risk or severity of adverse effects can be increased when Clemastine is combined with Sage 547.Investigational
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Clemastine.Approved
SaquinavirThe metabolism of Saquinavir can be decreased when combined with Clemastine.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Clemastine.Approved
ScopolamineThe risk or severity of adverse effects can be increased when Clemastine is combined with Scopolamine.Approved
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Clemastine.Approved, Vet Approved
SelegilineSelegiline may increase the anticholinergic activities of Clemastine.Approved, Investigational, Vet Approved
SelexipagThe metabolism of Selexipag can be decreased when combined with Clemastine.Approved
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Clemastine.Approved, Investigational
SertindoleThe metabolism of Sertindole can be decreased when combined with Clemastine.Approved, Withdrawn
SertralineThe metabolism of Sertraline can be decreased when combined with Clemastine.Approved
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Clemastine.Approved, Vet Approved
SibutramineThe metabolism of Sibutramine can be decreased when combined with Clemastine.Approved, Illicit, Investigational, Withdrawn
SildenafilThe metabolism of Sildenafil can be decreased when combined with Clemastine.Approved, Investigational
SilodosinThe metabolism of Silodosin can be decreased when combined with Clemastine.Approved
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Clemastine.Approved
SimvastatinThe metabolism of Simvastatin can be decreased when combined with Clemastine.Approved
SirolimusThe metabolism of Sirolimus can be decreased when combined with Clemastine.Approved, Investigational
SitagliptinThe metabolism of Sitagliptin can be decreased when combined with Clemastine.Approved, Investigational
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Clemastine.Approved
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Clemastine.Approved
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Clemastine.Approved, Investigational
SorafenibThe metabolism of Sorafenib can be decreased when combined with Clemastine.Approved, Investigational
SparteineThe metabolism of Sparteine can be decreased when combined with Clemastine.Experimental
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Clemastine.Approved
StiripentolThe risk or severity of adverse effects can be increased when Clemastine is combined with Stiripentol.Approved
SufentanilThe metabolism of Sufentanil can be decreased when combined with Clemastine.Approved, Investigational
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Clemastine.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Clemastine.Approved
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Clemastine.Approved
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Clemastine.Approved
SunitinibThe metabolism of Sunitinib can be decreased when combined with Clemastine.Approved, Investigational
SuvorexantClemastine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Clemastine.Approved
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Clemastine.Approved
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Clemastine.Approved, Investigational
TadalafilThe metabolism of Tadalafil can be decreased when combined with Clemastine.Approved, Investigational
TamoxifenThe serum concentration of the active metabolites of Tamoxifen can be reduced when Tamoxifen is used in combination with Clemastine resulting in a loss in efficacy.Approved
TamsulosinThe metabolism of Tamsulosin can be decreased when combined with Clemastine.Approved, Investigational
TandospironeThe risk or severity of adverse effects can be increased when Clemastine is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Clemastine.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Clemastine is combined with Tasimelteon.Approved
TasosartanThe metabolism of Tasosartan can be decreased when combined with Clemastine.Approved
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Clemastine.Experimental
TegaserodThe metabolism of Tegaserod can be decreased when combined with Clemastine.Investigational, Withdrawn
TelaprevirThe metabolism of Telaprevir can be decreased when combined with Clemastine.Approved
TelithromycinThe metabolism of Telithromycin can be decreased when combined with Clemastine.Approved
TemazepamThe metabolism of Temazepam can be decreased when combined with Clemastine.Approved
TemsirolimusThe metabolism of Temsirolimus can be decreased when combined with Clemastine.Approved
TeniposideThe metabolism of Teniposide can be decreased when combined with Clemastine.Approved
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Clemastine.Approved, Investigational, Vet Approved
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Clemastine.Withdrawn
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Clemastine.Investigational
TestosteroneThe metabolism of Testosterone can be decreased when combined with Clemastine.Approved, Investigational
TetrabenazineThe metabolism of Tetrabenazine can be decreased when combined with Clemastine.Approved
TetracaineThe risk or severity of adverse effects can be increased when Tetracaine is combined with Clemastine.Approved, Vet Approved
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Clemastine.Approved, Vet Approved
TetrodotoxinThe risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Clemastine.Investigational
ThalidomideClemastine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
TheophyllineThe metabolism of Theophylline can be decreased when combined with Clemastine.Approved
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Clemastine.Approved, Vet Approved
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Clemastine.Approved, Vet Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Clemastine.Approved
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Clemastine.Approved
ThiothixeneThe risk or severity of adverse effects can be increased when Thiothixene is combined with Clemastine.Approved
TiagabineThe metabolism of Tiagabine can be decreased when combined with Clemastine.Approved
TiaprideThe risk or severity of adverse effects can be increased when Clemastine is combined with Tiapride.Investigational
TicagrelorThe metabolism of Ticagrelor can be decreased when combined with Clemastine.Approved
TiclopidineThe metabolism of Ticlopidine can be decreased when combined with Clemastine.Approved
TiletamineThe risk or severity of adverse effects can be increased when Tiletamine is combined with Clemastine.Vet Approved
TimololThe metabolism of Timolol can be decreased when combined with Clemastine.Approved
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Clemastine.Approved, Investigational
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Clemastine.Approved
TipranavirThe metabolism of Tipranavir can be decreased when combined with Clemastine.Approved, Investigational
TizanidineThe risk or severity of adverse effects can be increased when Clemastine is combined with Tizanidine.Approved
TofacitinibThe metabolism of Tofacitinib can be decreased when combined with Clemastine.Approved, Investigational
TolcaponeThe risk or severity of adverse effects can be increased when Clemastine is combined with Tolcapone.Approved, Withdrawn
ToloxatoneToloxatone may increase the anticholinergic activities of Clemastine.Approved
TolterodineThe metabolism of Tolterodine can be decreased when combined with Clemastine.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Clemastine.Approved
TopiramateThe risk or severity of adverse effects can be increased when Topiramate is combined with Clemastine.Approved
ToremifeneThe metabolism of Toremifene can be decreased when combined with Clemastine.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Clemastine.Approved, Investigational
TramadolThe therapeutic efficacy of Tramadol can be decreased when used in combination with Clemastine.Approved, Investigational
Trans-2-PhenylcyclopropylamineTrans-2-Phenylcyclopropylamine may increase the anticholinergic activities of Clemastine.Experimental
TranylcypromineTranylcypromine may increase the anticholinergic activities of Clemastine.Approved
Trastuzumab emtansineThe metabolism of Trastuzumab emtansine can be decreased when combined with Clemastine.Approved
TrazodoneThe metabolism of Trazodone can be decreased when combined with Clemastine.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be decreased when combined with Clemastine.Approved, Investigational, Nutraceutical
TriamcinoloneThe metabolism of Triamcinolone can be decreased when combined with Clemastine.Approved, Vet Approved
TriazolamThe metabolism of Triazolam can be decreased when combined with Clemastine.Approved
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Clemastine.Approved
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Clemastine.Approved, Vet Approved
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Clemastine.Approved
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Clemastine.Approved, Vet Approved
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Clemastine.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Clemastine is combined with Triprolidine.Approved
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Clemastine.Withdrawn
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Clemastine.Approved
Uc1010The risk or severity of adverse effects can be increased when Clemastine is combined with Uc1010.Investigational
UdenafilThe metabolism of Udenafil can be decreased when combined with Clemastine.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Clemastine.Approved
UmeclidiniumThe metabolism of Umeclidinium can be decreased when combined with Clemastine.Approved
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Clemastine.Investigational, Withdrawn
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Clemastine.Approved, Investigational
VandetanibThe metabolism of Vandetanib can be decreased when combined with Clemastine.Approved
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Clemastine.Investigational
VardenafilThe metabolism of Vardenafil can be decreased when combined with Clemastine.Approved
VemurafenibThe metabolism of Vemurafenib can be decreased when combined with Clemastine.Approved
VenetoclaxThe metabolism of Venetoclax can be decreased when combined with Clemastine.Approved
VenlafaxineThe metabolism of Venlafaxine can be decreased when combined with Clemastine.Approved
VerapamilThe metabolism of Verapamil can be decreased when combined with Clemastine.Approved
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Clemastine.Investigational
VigabatrinThe risk or severity of adverse effects can be increased when Clemastine is combined with Vigabatrin.Approved
VilanterolThe metabolism of Vilanterol can be decreased when combined with Clemastine.Approved
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Clemastine.Approved
VinblastineThe metabolism of Vinblastine can be decreased when combined with Clemastine.Approved
VincristineThe metabolism of Vincristine can be decreased when combined with Clemastine.Approved, Investigational
VindesineThe serum concentration of Vindesine can be increased when it is combined with Clemastine.Approved
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Clemastine.Approved, Investigational
VismodegibThe metabolism of Vismodegib can be decreased when combined with Clemastine.Approved
VoriconazoleThe metabolism of Voriconazole can be decreased when combined with Clemastine.Approved, Investigational
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Clemastine.Approved
WarfarinThe metabolism of Warfarin can be decreased when combined with Clemastine.Approved
XylazineThe risk or severity of adverse effects can be increased when Xylazine is combined with Clemastine.Vet Approved
YohimbineThe metabolism of Yohimbine can be decreased when combined with Clemastine.Approved, Vet Approved
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Clemastine.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Clemastine.Approved
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Clemastine.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Clemastine is combined with Ziconotide.Approved
ZidovudineThe metabolism of Zidovudine can be decreased when combined with Clemastine.Approved
ZileutonThe metabolism of Zileuton can be decreased when combined with Clemastine.Approved, Investigational, Withdrawn
ZimelidineThe risk or severity of adverse effects can be increased when Clemastine is combined with Zimelidine.Withdrawn
ZiprasidoneThe metabolism of Ziprasidone can be decreased when combined with Clemastine.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Zolazepam is combined with Clemastine.Vet Approved
ZolpidemClemastine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Clemastine.Withdrawn
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Clemastine.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Clemastine.Approved
ZotepineThe risk or severity of adverse effects can be increased when Zotepine is combined with Clemastine.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Clemastine.Approved, Investigational
Food Interactions
  • Avoid alcohol.
  • Take with food.
References
Synthesis Reference

British Patent 942,152; November 20,1963; assigned to Sandoz Ltd.

General References
  1. Hayashi H, Okajima M, Yamada K: Atrial T (Ta) loop in dogs with or without atrial injury. Am Heart J. 1976 May;91(5):607-17. [PubMed:1266718 ]
  2. Schran HF, Petryk L, Chang CT, O'Connor R, Gelbert MB: The pharmacokinetics and bioavailability of clemastine and phenylpropanolamine in single-component and combination formulations. J Clin Pharmacol. 1996 Oct;36(10):911-22. [PubMed:8930778 ]
External Links
ATC CodesD04AA14R06AA04R06AA54
AHFS Codes
  • 04:04.04
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (74.2 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9942
Blood Brain Barrier+0.9918
Caco-2 permeable+0.6652
P-glycoprotein substrateSubstrate0.6659
P-glycoprotein inhibitor IInhibitor0.808
P-glycoprotein inhibitor IIInhibitor0.8388
Renal organic cation transporterInhibitor0.8471
CYP450 2C9 substrateNon-substrate0.819
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.7176
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorNon-inhibitor0.907
CYP450 2D6 inhibitorInhibitor0.8931
CYP450 2C19 inhibitorInhibitor0.8993
CYP450 3A4 inhibitorInhibitor0.7028
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.5
Ames testNon AMES toxic0.7454
CarcinogenicityNon-carcinogens0.8549
BiodegradationNot ready biodegradable0.9972
Rat acute toxicity2.9450 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Strong inhibitor0.5986
hERG inhibition (predictor II)Inhibitor0.8702
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Actavis mid atlantic llc
  • Novex pharma
  • Silarx pharmaceuticals inc
  • Teva pharmaceuticals usa inc
  • Teva pharmaceuticals usa
  • Wockhardt eu operations (swiss) ag
  • Novartis pharmaceuticals corp
  • Perrigo co
  • Sandoz inc
Packagers
Dosage forms
FormRouteStrength
SyrupOral.5 mg/mL
TabletOral2.68 mg/1
TabletOral1.34 mg/1
TabletOral1 mg
Tablet, extended releaseOral
Prices
Unit descriptionCostUnit
Clemastine fumarate powder255.0USD g
Clemastine Fumarate 0.67 mg/5ml Syrup 120ml Bottle22.2USD bottle
Clemastine Fumarate 2.68 mg tablet0.9USD tablet
Clemastine fum 2.68 mg tablet0.86USD tablet
Tavist nd 10 mg tablet0.74USD tablet
Clemastine fum 1.34 mg tablet0.58USD tablet
Tavist-1 1.34 mg tablet0.5USD tablet
Clemastine Fumarate 1.34 mg tablet0.34USD tablet
Dayhist tablet0.31USD tablet
CVS Pharmacy dayhist allergy tablet0.28USD tablet
Dayhist-1 1.34 mg tablet0.25USD tablet
Tavist max-str sinus caplet0.17USD caplet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point178 °C (hydrogen fumarate formulation)Not Available
water solubilitySoluble (hydrogen fumarate formulation)Not Available
logP5.2Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.000405 mg/mLALOGPS
logP5.29ALOGPS
logP4.92ChemAxon
logS-5.9ALOGPS
pKa (Strongest Basic)9.55ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area12.47 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity101.65 m3·mol-1ChemAxon
Polarizability39.06 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassDiphenylmethanes
Direct ParentDiphenylmethanes
Alternative Parents
Substituents
  • Diphenylmethane
  • Benzylether
  • Halobenzene
  • Chlorobenzene
  • N-alkylpyrrolidine
  • Aryl halide
  • Aryl chloride
  • Pyrrolidine
  • Tertiary aliphatic amine
  • Tertiary amine
  • Azacycle
  • Organoheterocyclic compound
  • Ether
  • Dialkyl ether
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Amine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Histamine receptor activity
Specific Function:
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
Gene Name:
HRH1
Uniprot ID:
P35367
Molecular Weight:
55783.61 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  2. Taniguchi K, Urakami M, Takanaka K: [Effects of antiallergic agents on polymorphonuclear leukocytes. The inhibition of arachidonic acid release and superoxide production]. Nihon Yakurigaku Zasshi. 1987 Aug;90(2):97-103. [PubMed:2890562 ]
  3. Hallberg T, Dohlsten M, Baldetorp B: Demonstration of histamine receptors on human platelets by flow cytometry. Scand J Haematol. 1984 Feb;32(2):113-8. [PubMed:6701456 ]
  4. Dorsch W, Hintschich C, Neuhauser J, Weber J: Sequential histamine inhalations cause increased bronchial histamine reactivity in guinea pigs: role of platelets, thromboxanes and prostacyclin. Naunyn Schmiedebergs Arch Pharmacol. 1984 Sep;327(2):148-55. [PubMed:6387510 ]
  5. Taniguchi K, Masuda Y, Takanaka K: Inhibitory effects of histamine H1 receptor blocking drugs on metabolic activations of neutrophils. J Pharmacobiodyn. 1991 Feb;14(2):87-93. [PubMed:1678430 ]
  6. Oishi R, Shishido S, Yamori M, Saeki K: Comparison of the effects of eleven histamine H1-receptor antagonists on monoamine turnover in the mouse brain. Naunyn Schmiedebergs Arch Pharmacol. 1994 Feb;349(2):140-4. [PubMed:7513381 ]
  7. Thomas RH, Browne PD, Kirby JD: The influence of ranitidine, alone and in combination with clemastine, on histamine-mediated cutaneous weal and flare reactions in human skin. Br J Clin Pharmacol. 1985 Oct;20(4):377-82. [PubMed:4074605 ]
  8. Thomson NC, Kerr JW: Effect of inhaled H1 and H2 receptor antagonist in normal and asthmatic subjects. Thorax. 1980 Jun;35(6):428-34. [PubMed:6449094 ]
  9. Hayashi H, Okajima M, Yamada K: Atrial T (Ta) loop in dogs with or without atrial injury. Am Heart J. 1976 May;91(5):607-17. [PubMed:1266718 ]
  10. Schran HF, Petryk L, Chang CT, O'Connor R, Gelbert MB: The pharmacokinetics and bioavailability of clemastine and phenylpropanolamine in single-component and combination formulations. J Clin Pharmacol. 1996 Oct;36(10):911-22. [PubMed:8930778 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
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Drug created on June 13, 2005 07:24 / Updated on December 08, 2016 11:11