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Identification
NameMontelukast
Accession NumberDB00471  (APRD00434)
TypeSmall Molecule
GroupsApproved
DescriptionMontelukast is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. It is usually administered orally. Montelukast blocks the action of leukotriene D4 on the cysteinyl leukotriene receptor CysLT1 in the lungs and bronchial tubes by binding to it. This reduces the bronchoconstriction otherwise caused by the leukotriene, and results in less inflammation. Because of its method of operation, it is not useful for the treatment of acute asthma attacks. Again because of its very specific locus of operation, it does not interact with other allergy medications such as theophylline. Montelukast is marketed in United States and many other countries by Merck & Co. with the brand name Singulair®. It is available as oral tablets, chewable tablets, and oral granules. In India and other countries, it is also marketed under the brand name Montair®, produced by Indian company Cipla.
Structure
Thumb
Synonyms
(R-(e))-1-(((1-(3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetic acid
1-[[[(1 R)-1-[3-[(1e)-2-(7-chloro-2-Quinolinyl)ethenyl] phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]sulfanyl]methyl]cyclopropaneacetic acid
Montelukast
Montélukast
Montelukastum
External Identifiers
  • L 706631
  • MK 0476
  • MK 476
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Accel-montelukast Sodium TabletsTablet10 mgOralAccel Pharma IncNot applicableNot applicableCanada
Ach-montelukastTablet, chewable4 mgOralAccord Healthcare Inc2014-06-09Not applicableCanada
Ach-montelukastTablet, chewable5 mgOralAccord Healthcare Inc2014-06-09Not applicableCanada
Auro-montelukastTablet10 mgOralAuro Pharma Inc2013-03-04Not applicableCanada
Auro-montelukast Chewable TabletTablet, chewable4 mgOralAuro Pharma Inc2014-03-26Not applicableCanada
Auro-montelukast Chewable TabletTablet, chewable5 mgOralAuro Pharma Inc2014-03-26Not applicableCanada
Bio-montelukastTablet10 mgOralBiomed PharmaNot applicableNot applicableCanada
Dom-montelukastTablet, chewable4 mgOralDominion Pharmacal2012-10-03Not applicableCanada
Dom-montelukastTablet, chewable5 mgOralDominion Pharmacal2012-10-03Not applicableCanada
Dom-montelukast FcTablet10 mgOralDominion Pharmacal2012-09-26Not applicableCanada
Ipg-montelukastTablet, chewable5 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-montelukastTablet10 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-montelukastTablet, chewable4 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Jamp-montelukastTablet, chewable5 mgOralJamp Pharma CorporationNot applicableNot applicableCanada
Jamp-montelukastTablet10 mgOralJamp Pharma Corporation2012-09-21Not applicableCanada
Jamp-montelukastTablet, chewable4 mgOralJamp Pharma CorporationNot applicableNot applicableCanada
Mar-montelukastTablet, chewable4 mgOralMarcan Pharmaceuticals Inc2013-12-30Not applicableCanada
Mar-montelukastTablet, chewable5 mgOralMarcan Pharmaceuticals Inc2013-12-30Not applicableCanada
Mar-montelukastTablet10 mgOralMarcan Pharmaceuticals Inc2013-12-30Not applicableCanada
Mint-montelukastTablet10 mgOralMint Pharmaceuticals Inc2013-10-17Not applicableCanada
Mint-montelukastTablet, chewable4 mgOralMint Pharmaceuticals Inc2013-10-17Not applicableCanada
Mint-montelukastTablet, chewable5 mgOralMint Pharmaceuticals Inc2013-10-17Not applicableCanada
MontelukastTablet10 mgOralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
MontelukastTablet10 mgOralSivem Pharmaceuticals Ulc2012-06-10Not applicableCanada
MontelukastTablet, chewable4 mgOralPro Doc Limitee2012-03-29Not applicableCanada
MontelukastTablet, chewable4 mgOralSanis Health Inc2012-03-21Not applicableCanada
MontelukastTablet, chewable4 mgOralSivem Pharmaceuticals Ulc2012-06-10Not applicableCanada
MontelukastTablet, chewable5 mgOralPro Doc Limitee2012-03-29Not applicableCanada
MontelukastTablet, chewable5 mgOralSanis Health Inc2012-03-21Not applicableCanada
MontelukastTablet, chewable5 mgOralSivem Pharmaceuticals Ulc2012-06-10Not applicableCanada
MontelukastTablet10 mgOralSanis Health Inc2012-03-21Not applicableCanada
MontelukastTablet10 mgOralPro Doc Limitee2012-03-29Not applicableCanada
Montelukast SodiumGranule4 mg/1OralPrasco Laboratories2013-07-26Not applicableUs
Montelukast Sodium TabletsTablet10 mgOralAccord Healthcare Inc2012-03-28Not applicableCanada
Mylan-montelukastTablet, chewable4 mgOralMylan Pharmaceuticals Ulc2012-02-27Not applicableCanada
Mylan-montelukastTablet, chewable5 mgOralMylan Pharmaceuticals Ulc2012-02-27Not applicableCanada
Mylan-montelukastTablet10 mgOralMylan Pharmaceuticals Ulc2011-10-20Not applicableCanada
Ntp-montelukastTablet, chewable4 mgOralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-montelukastTablet, chewable5 mgOralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-montelukastTablet10 mgOralTeva Canada LimitedNot applicableNot applicableCanada
Pendo-montelukastTablet, chewable4 mgOralPendopharm Division Of De Pharmascience IncNot applicableNot applicableCanada
Pendo-montelukastTablet, chewable5 mgOralPendopharm Division Of De Pharmascience IncNot applicableNot applicableCanada
Pendo-montelukast FcTablet10 mgOralPendopharm Division Of De Pharmascience IncNot applicableNot applicableCanada
PMS-montelukastTablet, chewable4 mgOralPharmascience Inc2011-10-11Not applicableCanada
PMS-montelukastTablet, chewable5 mgOralPharmascience Inc2011-10-11Not applicableCanada
PMS-montelukast FcTablet10 mgOralPharmascience Inc2011-10-11Not applicableCanada
Priva-montelukast FcTablet10 mgOralPharmapar IncNot applicableNot applicableCanada
Q-montelukastTablet10 mgOralQd Pharmaceuticals UlcNot applicableNot applicableCanada
Ran-montelukastTablet, chewable4 mgOralRanbaxy Pharmaceuticals Canada Inc.2013-07-08Not applicableCanada
Ran-montelukastTablet, chewable5 mgOralRanbaxy Pharmaceuticals Canada Inc.2013-07-08Not applicableCanada
Ran-montelukastTablet10 mgOralRanbaxy Pharmaceuticals Canada Inc.2013-01-17Not applicableCanada
Ratio-montelukastTablet, chewable4 mgOralTeva Canada LimitedNot applicableNot applicableCanada
Ratio-montelukastTablet, chewable5 mgOralTeva Canada LimitedNot applicableNot applicableCanada
Ratio-montelukastTablet10 mgOralTeva Canada LimitedNot applicableNot applicableCanada
Riva-montelukastTablet, chewable4 mgOralLaboratoire Riva IncNot applicableNot applicableCanada
Riva-montelukastTablet, chewable5 mgOralLaboratoire Riva IncNot applicableNot applicableCanada
Riva-montelukast FcTablet10 mgOralLaboratoire Riva Inc2013-01-17Not applicableCanada
Sandoz MontelukastTablet, chewable4 mgOralSandoz Canada Incorporated2011-10-11Not applicableCanada
Sandoz MontelukastTablet, chewable5 mgOralSandoz Canada Incorporated2011-10-11Not applicableCanada
Sandoz Montelukast GranulesGranule4 mgOralSandoz Canada Incorporated2011-10-11Not applicableCanada
Sandoz Montelukast TabletTablet10 mgOralSandoz Canada Incorporated2011-10-11Not applicableCanada
SingulairGranule10 mg/1OralREMEDYREPACK INC.2013-03-012016-10-13Us
SingulairGranule4 mg/1OralMerck Sharp & Dohme Corp.2002-07-26Not applicableUs
SingulairTablet, film coated10 mg/1OralDispensing Solutions Inc.2009-10-08Not applicableUs
SingulairTablet, film coated10 mg/1OralRebel Distributors Corp1998-02-20Not applicableUs
SingulairTablet, chewable5 mg/1OralCardinal Health1998-02-20Not applicableUs
SingulairGranule4 mgOralMerck Canada Inc2004-02-20Not applicableCanada
SingulairTablet, film coated10 mg/1OralPhysicians Total Care, Inc.2000-12-05Not applicableUs
SingulairTablet, chewable4 mg/1Oralbryant ranch prepack1998-02-20Not applicableUs
SingulairTablet, chewable5 mg/1OralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-03-21Not applicableUs
SingulairTablet, film coated10 mg/1OralA S Medication Solutions Llc1998-08-12Not applicableUs
SingulairTablet, film coated10 mg/1OralMerck Sharp & Dohme Corp.1998-02-20Not applicableUs
SingulairTablet, chewable5 mgOralMerck Canada Inc1998-08-21Not applicableCanada
SingulairTablet, film coated10 mg/1OralPd Rx Pharmaceuticals, Inc.1998-02-20Not applicableUs
SingulairTablet, chewable5 mg/1OralRebel Distributors Corp1998-02-20Not applicableUs
SingulairTablet, chewable4 mg/1OralPhysicians Total Care, Inc.2002-05-30Not applicableUs
SingulairTablet, chewable5 mg/1Oralbryant ranch prepack1998-02-20Not applicableUs
SingulairTablet, chewable4 mg/1OralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-03-21Not applicableUs
SingulairTablet10 mgOralMerck Canada Inc1998-08-21Not applicableCanada
SingulairTablet, chewable5 mg/1OralA S Medication Solutions Llc2000-11-10Not applicableUs
SingulairTablet, chewable5 mg/1OralMerck Sharp & Dohme Corp.1998-02-20Not applicableUs
SingulairTablet, chewable4 mg/1OralPd Rx Pharmaceuticals, Inc.1998-02-20Not applicableUs
SingulairTablet, film coated10 mg/1OralREMEDYREPACK INC.2013-03-282016-10-22Us
SingulairTablet, chewable5 mg/1OralPhysicians Total Care, Inc.2003-07-03Not applicableUs
SingulairGranule5 mg/1OralREMEDYREPACK INC.2013-02-262016-10-13Us
SingulairTablet, chewable4 mg/1OralMerck Sharp & Dohme Corp.1998-02-20Not applicableUs
SingulairTablet, chewable5 mg/1OralDispensing Solutions Inc.2009-10-08Not applicableUs
SingulairTablet, chewable4 mgOralMerck Canada Inc2001-04-09Not applicableCanada
SingulairTablet, chewable4 mg/1OralA S Medication Solutions Llc1999-04-23Not applicableUs
SingulairTablet, film coated10 mg/1Oralbryant ranch prepack1998-02-20Not applicableUs
SingulairTablet, film coated10 mg/1OralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-03-21Not applicableUs
SingulairTablet, film coated10 mg/1OralCardinal Health1998-02-20Not applicableUs
Teva-montelukastTablet10 mgOralTeva Canada Limited2011-10-11Not applicableCanada
Teva-montelukastTablet, chewable4 mgOralTeva Canada Limited2011-10-11Not applicableCanada
Teva-montelukastTablet, chewable5 mgOralTeva Canada Limited2011-10-11Not applicableCanada
Uni-montelukastTablet, chewable4 mgOralUnimark Remedies LimitedNot applicableNot applicableCanada
Uni-montelukastTablet10 mgOralUnimark Remedies LimitedNot applicableNot applicableCanada
Uni-montelukastTablet, chewable5 mgOralUnimark Remedies LimitedNot applicableNot applicableCanada
Van-montelukastTablet10 mgOralVanc Pharmaceuticals IncNot applicableNot applicableCanada
Van-montelukastTablet, chewable4 mgOralVanc Pharmaceuticals IncNot applicableNot applicableCanada
Van-montelukastTablet, chewable5 mgOralVanc Pharmaceuticals IncNot applicableNot applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-montelukastTablet, chewable4 mgOralApotex Inc2013-02-15Not applicableCanada
Apo-montelukastTablet, chewable5 mgOralApotex Inc2013-02-15Not applicableCanada
Apo-montelukastTablet10 mgOralApotex Inc2012-01-20Not applicableCanada
MontelukastTablet, chewable5 mg/1OralPreferred Pharmaceuticals Inc.2016-09-13Not applicableUs
MontelukastTablet, film coated10 mg/1OralWest ward Pharmaceutical Corp2014-12-01Not applicableUs
MontelukastTablet, film coated10 mg/1OralKemwell Biopharma Private Limited2014-12-01Not applicableUs
MontelukastTablet, chewable5 mg/1OralAse Direct, Inc.2014-12-01Not applicableUs
MontelukastTablet, chewable5 mg/1OralBionpharma Inc.2014-12-01Not applicableUs
MontelukastTablet10 mg/1OralMacleods Pharmaceuticals Limited2012-02-28Not applicableUs
MontelukastTablet, chewable4 mg/1OralSandoz Inc2012-08-03Not applicableUs
MontelukastTablet, chewable5 mg/1OralWest ward Pharmaceutical Corp2014-12-01Not applicableUs
MontelukastTablet, chewable4 mg/1OralKemwell Biopharma Private Limited2014-12-01Not applicableUs
MontelukastTablet, film coated10 mg/1OralAse Direct, Inc.2014-12-01Not applicableUs
MontelukastTablet, film coated10 mg/1OralBionpharma Inc.2014-12-01Not applicableUs
MontelukastTablet, chewable5 mg/1OralSandoz Inc2012-08-03Not applicableUs
MontelukastTablet, film coated10 mg/1OralInternational Laboratories, Inc.2013-10-04Not applicableUs
MontelukastTablet, chewable5 mg/1OralProficient Rx LP2014-12-01Not applicableUs
MontelukastTablet, chewable4 mg/1OralWest ward Pharmaceutical Corp2014-12-01Not applicableUs
MontelukastTablet, chewable5 mg/1OralKemwell Biopharma Private Limited2014-12-01Not applicableUs
MontelukastTablet, film coated10 mg/1Oralbryant ranch prepack2012-08-03Not applicableUs
MontelukastTablet, film coated10 mg/1OralCamber Pharmaceuticals, Inc.2014-09-10Not applicableUs
MontelukastTablet, chewable4 mg/1OralAse Direct, Inc.2014-12-01Not applicableUs
MontelukastTablet, chewable4 mg/1OralBionpharma Inc.2014-12-01Not applicableUs
MontelukastTablet, film coated10 mg/1OralSandoz Inc2012-08-03Not applicableUs
MontelukastTablet, film coated10 mg/1OralClinical Solutions Wholesale2012-08-03Not applicableUs
Montelukast SodiumTablet10 mg/1OralA S Medication Solutions2012-08-03Not applicableUs
Montelukast SodiumTablet, chewable5 mg/1OralHangzhou Minsheng Binjiang Pharmaceutical Co., Ltd.2015-11-30Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralLegacy Pharmaceutical Packaging2012-08-03Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralKremers Urban Pharmaceuticals Inc.2012-08-03Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2012-08-03Not applicableUs
Montelukast SodiumTablet, chewable5 mg/1OralAv Kare, Inc.2013-01-02Not applicableUs
Montelukast SodiumTablet, chewable4 mg/1OralCamber Pharmaceuticals, Inc.2015-05-27Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralState of Florida DOH Central Pharmacy2014-11-01Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralAurobindo Pharma Limited2012-08-03Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralCardinal Health2012-08-03Not applicableUs
Montelukast SodiumTablet, chewable5 mg/1OralLucid Pharma Llc2012-08-03Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralReady Meds2012-08-03Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralA S Medication Solutions2013-04-11Not applicableUs
Montelukast SodiumTablet, chewable4 mg/1OralQualitest Pharmaceuticals2012-08-03Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralAccord Healthcare Inc.2013-01-15Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralAphena Pharma Solutions Tennessee, Llc2012-08-10Not applicableUs
Montelukast SodiumTablet, chewable5 mg/1OralMacleods Pharmaceuticals Limited2013-12-27Not applicableUs
Montelukast SodiumTablet, chewable4 mg/1OralDr.Reddy's Laboratories Limited2012-08-06Not applicableUs
Montelukast SodiumTablet, chewable4 mg/1OralProficient Rx LP2012-08-03Not applicableUs
Montelukast SodiumTablet, chewable5 mg/1OralWest Ward Pharmaceuticals Corp.2012-08-03Not applicableUs
Montelukast SodiumTablet10 mg/1OralMajor Pharmaceuticals2012-08-03Not applicableUs
Montelukast SodiumTablet, chewable5 mg/1OralCitron Pharma LLC2012-08-03Not applicableUs
Montelukast SodiumTablet, coated10 mg/1OralAjanta Pharma Limited2015-08-13Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralMylan Institutional Inc.2012-08-28Not applicableUs
Montelukast SodiumTablet, chewable4 mg/1OralCarilion Materials Management2012-08-03Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralCarilion Materials Management2012-08-03Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralAmerican Health Packaging2012-07-022016-02-29Us
Montelukast SodiumTablet, film coated10 mg/1OralApotex Corp2012-08-03Not applicableUs
Montelukast SodiumTablet10 mg/1OralAvera Mc Kennan Hospital2015-07-03Not applicableUs
Montelukast SodiumTablet, chewable4 mg/1OralMylan Pharmaceuticals Inc.2012-08-03Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralPhysicians Total Care, Inc.2012-08-09Not applicableUs
Montelukast SodiumTablet, chewable5 mg/1OralA S Medication Solutions2012-08-03Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralProficient Rx LP2012-08-03Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralPreferred Pharmaceuticals Inc.2016-06-17Not applicableUs
Montelukast SodiumTablet, chewable4 mg/1OralPreferred Pharmaceuticals, Inc.2014-05-05Not applicableUs
Montelukast SodiumTablet, coated10 mg/1OralREMEDYREPACK INC.2015-05-21Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralLucid Pharma Llc2012-08-03Not applicableUs
Montelukast SodiumTablet, chewable5 mg/1OralCamber Pharmaceuticals, Inc.2015-05-27Not applicableUs
Montelukast SodiumGranule4 mg/1OralAjanta Pharma Limited2015-08-13Not applicableUs
Montelukast SodiumTablet, chewable4 mg/1OralAv Pak2014-11-11Not applicableUs
Montelukast SodiumTablet, chewable5 mg/1OralAmerican Health Packaging2015-02-152016-11-30Us
Montelukast SodiumTablet, film coated10 mg/1OralCardinal Health2012-08-29Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralCardinal Health2012-08-03Not applicableUs
Montelukast SodiumTablet10 mg/1OralAmneal Pharmaceuticals of New York, LLC2013-07-31Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralA S Medication Solutions2012-08-03Not applicableUs
Montelukast SodiumTablet, chewable5 mg/1OralQualitest Pharmaceuticals2012-08-03Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralRebel Distributors Corp2012-08-03Not applicableUs
Montelukast SodiumTablet, chewable5 mg/1OralDr.Reddy's Laboratories Limited2012-08-06Not applicableUs
Montelukast SodiumTablet, chewable4 mg/1Oralbryant ranch prepack2012-08-03Not applicableUs
Montelukast SodiumTablet, chewable4 mg/1OralProficient Rx LP2015-11-10Not applicableUs
Montelukast SodiumTablet, chewable5 mg/1OralAmerican Health Packaging2012-07-022015-12-31Us
Montelukast SodiumTablet, chewable4 mg/1OralTeva Pharmaceuticals Usa, Inc.2012-08-03Not applicableUs
Montelukast SodiumTablet, chewable4 mg/1OralTorrent Pharmaceuticals Limited2012-08-03Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralCitron Pharma LLC2012-08-03Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralUnichem Pharmaceuticals (USA), Inc.2016-01-01Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Montelukast SodiumTablet10 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2012-08-03Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralLegacy Pharmaceutical Packaging, Llc2012-08-03Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralCarilion Materials Management2012-08-03Not applicableUs
Montelukast SodiumTablet, chewable4 mg/1OralApotex Corp2012-08-03Not applicableUs
Montelukast SodiumTablet, chewable4 mg/1OralKremers Urban Pharmaceuticals Inc.2012-08-03Not applicableUs
Montelukast SodiumTablet, chewable5 mg/1OralMylan Pharmaceuticals Inc.2012-08-03Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralAv Kare, Inc.2012-08-10Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralAidarex Pharmaceuticals LLC2012-08-03Not applicableUs
Montelukast SodiumTablet, chewable5 mg/1OralPhysicians Total Care, Inc.2012-08-09Not applicableUs
Montelukast SodiumTablet, chewable5 mg/1OralA S Medication Solutions2012-08-03Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralProficient Rx LP2012-08-03Not applicableUs
Montelukast SodiumTablet10 mg/1OralWest Ward Pharmaceuticals Corp.2012-08-03Not applicableUs
Montelukast SodiumTablet, chewable4 mg/1OralAjanta Pharma Limited2015-08-13Not applicableUs
Montelukast SodiumTablet, chewable5 mg/1OralAv Pak2014-11-12Not applicableUs
Montelukast SodiumTablet, coated10 mg/1OralAmerican Health Packaging2015-02-15Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralCardinal Health2013-05-23Not applicableUs
Montelukast SodiumTablet10 mg/1OralHangzhou Minsheng Binjiang Pharm2016-05-30Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralMed Vantx, Inc.2012-08-03Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralREMEDYREPACK INC.2016-10-27Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralQualitest Pharmaceuticals2012-08-03Not applicableUs
Montelukast SodiumTablet, chewable5 mg/1OralTorrent Pharmaceuticals Limited2012-08-03Not applicableUs
Montelukast SodiumTablet, chewable4 mg/1OralAurobindo Pharma Limited2012-08-03Not applicableUs
Montelukast SodiumTablet10 mg/1OralPd Rx Pharmaceuticals, Inc.2012-08-03Not applicableUs
Montelukast SodiumTablet, coated10 mg/1OralDr.Reddy's Laboratories Limited2012-08-06Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralDIRECT RX2014-01-01Not applicableUs
Montelukast SodiumTablet, chewable4 mg/1OralAmerican Health Packaging2013-05-222015-12-31Us
Montelukast SodiumTablet, chewable5 mg/1OralTeva Pharmaceuticals Usa, Inc.2012-08-03Not applicableUs
Montelukast SodiumTablet, chewable5 mg/1OralApotex Corp2012-08-03Not applicableUs
Montelukast SodiumTablet, chewable5 mg/1OralKremers Urban Pharmaceuticals Inc.2012-08-03Not applicableUs
Montelukast SodiumGranule4 mg/500mgOralMylan Pharmaceuticals Inc.2013-09-18Not applicableUs
Montelukast SodiumTablet, chewable4 mg/1OralAv Kare, Inc.2013-01-02Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralA S Medication Solutions2012-08-032016-10-25Us
Montelukast SodiumTablet, chewable4 mg/1OralHangzhou Minsheng Binjiang Pharmaceutical Co., Ltd.2015-11-30Not applicableUs
Montelukast SodiumTablet, chewable5 mg/1OralPreferred Pharmaceuticals Inc.2016-06-08Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralGlenmark Pharmaceuticals Inc., Usa2012-08-03Not applicableUs
Montelukast SodiumTablet, chewable4 mg/1OralMacleods Pharmaceuticals Limited2014-04-01Not applicableUs
Montelukast SodiumTablet, chewable4 mg/1OralPhysicians Total Care, Inc.2012-08-09Not applicableUs
Montelukast SodiumTablet, chewable4 mg/1OralA S Medication Solutions2012-08-03Not applicableUs
Montelukast SodiumTablet10 mg/1OralProficient Rx LP2012-08-03Not applicableUs
Montelukast SodiumTablet, chewable4 mg/1OralWest Ward Pharmaceuticals Corp.2012-08-03Not applicableUs
Montelukast SodiumTablet, chewable4 mg/1OralCitron Pharma LLC2012-08-03Not applicableUs
Montelukast SodiumTablet, chewable5 mg/1OralAjanta Pharma Limited2015-08-13Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralAv Pak2014-10-02Not applicableUs
Montelukast SodiumTablet, chewable5 mg/1OralCarilion Materials Management2012-08-03Not applicableUs
Montelukast SodiumTablet, coated10 mg/1OralProficient Rx LP2015-11-10Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralBlue Point Laboratories2014-03-13Not applicableUs
Montelukast SodiumTablet, coated10 mg/1OralLegacy Pharmaceutical Packaging, Llc2012-08-06Not applicableUs
Montelukast SodiumTablet, chewable5 mg/1OralPreferred Pharmaceuticals Inc.2016-02-01Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralMylan Pharmaceuticals Inc.2012-08-03Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralMajor Pharmaceuticals2012-08-03Not applicableUs
Montelukast SodiumTablet, chewable4 mg/1OralA S Medication Solutions2012-08-03Not applicableUs
Montelukast SodiumTablet, film coated10 mg/1OralTeva Pharmaceuticals Usa, Inc.2012-08-03Not applicableUs
Montelukast SodiumTablet10 mg/1OralTorrent Pharmaceuticals Limited2012-08-03Not applicableUs
Montelukast SodiumTablet, chewable5 mg/1OralAurobindo Pharma Limited2012-08-03Not applicableUs
Montelukast SodiumTablet, chewable4 mg/1OralPd Rx Pharmaceuticals, Inc.2012-08-03Not applicableUs
Montelukast SodiumGranule4 mg/1OralDr.Reddy's Laboratories Limited2012-09-20Not applicableUs
Montelukast SodiumTablet, chewable4 mg/1OralLucid Pharma Llc2012-08-03Not applicableUs
Montelukast SodiumTablet, chewable5 mg/1Oralbryant ranch prepack2012-08-03Not applicableUs
Montelukast Sodium ChewableTablet, chewable4 mg/1OralJubilant Cadista Pharmaceuticals Inc.2015-02-28Not applicableUs
Montelukast Sodium ChewableTablet, chewable5 mg/1OralJubilant Cadista Pharmaceuticals Inc.2015-02-28Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
LukotasNot Available
MollyAllenge
MonocastBeximco
MontefloNot Available
Montelo-10Not Available
MonteneSquare
RespaireSanta-Farma
SurfairSandoz
TelumantesActavis
VentekSearle
VentilarGutis
XalarUnimed
ZespiraBilim
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Montelukast sodium
ThumbNot applicableDBSALT001043
Categories
UNIIMHM278SD3E
CAS number158966-92-8
WeightAverage: 586.183
Monoisotopic: 585.21044242
Chemical FormulaC35H36ClNO3S
InChI KeyUCHDWCPVSPXUMX-TZIWLTJVSA-N
InChI
InChI=1S/C35H36ClNO3S/c1-34(2,40)30-9-4-3-7-25(30)13-17-32(41-23-35(18-19-35)22-33(38)39)27-8-5-6-24(20-27)10-15-29-16-12-26-11-14-28(36)21-31(26)37-29/h3-12,14-16,20-21,32,40H,13,17-19,22-23H2,1-2H3,(H,38,39)/b15-10+/t32-/m1/s1
IUPAC Name
2-[1-({[(1R)-1-{3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl}-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanyl}methyl)cyclopropyl]acetic acid
SMILES
OC(=O)CC1(CC1)CS[[email protected]](CCC1=CC=CC=C1C(O)(C)C)C1=CC=CC(\C=C\C2=NC3=C(C=CC(Cl)=C3)C=C2)=C1
Pharmacology
IndicationFor the treatment of asthma
Structured Indications
PharmacodynamicsMontelukast, like zafirlukast, is a leukotriene receptor antagonist used as an alternative to anti-inflammatory medications in the management and chronic treatment of asthma and exercise-induced bronchospasm (EIB). Unlike zafirlukast, montelukast does not inhibit CYP2C9 or CYP3A4 and is, therefore, not expected to affect the hepatic clearance of drugs metabolized by these enzymes.
Mechanism of actionMontelukast selectively antagonizes leukotriene D4 (LTD4) at the cysteinyl leukotriene receptor, CysLT1, in the human airway. Montelukast inhibits the actions of LTD4 at the CysLT1 receptor, preventing airway edema, smooth muscle contraction, and enhanced secretion of thick, viscous mucus.
TargetKindPharmacological actionActionsOrganismUniProt ID
Cysteinyl leukotriene receptor 1Proteinyes
antagonist
HumanQ9Y271 details
Arachidonate 5-lipoxygenaseProteinunknown
other/unknown
HumanP09917 details
Related Articles
AbsorptionRapidly absorbed following oral administration (bioavailability is 64%)
Volume of distribution
  • 8 to 11 L
Protein binding99% (to plasma proteins)
Metabolism

Hepatic

SubstrateEnzymesProduct
Montelukast
Not Available
Montelukast metabolite M1Details
Montelukast
Montelukast metabolite M2aDetails
Montelukast
Montelukast metabolite M2bDetails
Montelukast
Montelukast metabolite M5aDetails
Montelukast
Montelukast metabolite M5bDetails
Montelukast
Montelukast metabolite M6aDetails
Montelukast
Montelukast metabolite M6bDetails
Route of eliminationCoupled with estimates of montelukast oral bioavailability, this indicates that montelukast and its metabolites are excreted almost exclusively via the bile.
Half life2.7-5.5 hours
Clearance
  • 45 mL/min [healthy adults]
ToxicitySide effects include headache, abdominal or stomach pain, cough, dental pain, dizziness, fever, heartburn, skin rash, stuffy nose, weakness or unusual tiredness.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
AbirateroneThe metabolism of Montelukast can be decreased when combined with Abiraterone.Approved
AmiodaroneThe metabolism of Montelukast can be decreased when combined with Amiodarone.Approved, Investigational
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Montelukast.Approved
AprepitantThe serum concentration of Montelukast can be increased when it is combined with Aprepitant.Approved, Investigational
AtazanavirThe metabolism of Montelukast can be decreased when combined with Atazanavir.Approved, Investigational
AtomoxetineThe metabolism of Montelukast can be decreased when combined with Atomoxetine.Approved
BexaroteneThe serum concentration of Montelukast can be decreased when it is combined with Bexarotene.Approved, Investigational
BoceprevirThe metabolism of Montelukast can be decreased when combined with Boceprevir.Approved
BortezomibThe metabolism of Montelukast can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Montelukast can be decreased when it is combined with Bosentan.Approved, Investigational
CapecitabineThe metabolism of Montelukast can be decreased when combined with Capecitabine.Approved, Investigational
CarbamazepineThe metabolism of Montelukast can be increased when combined with Carbamazepine.Approved, Investigational
CeritinibThe serum concentration of Montelukast can be increased when it is combined with Ceritinib.Approved
CholecalciferolThe metabolism of Montelukast can be decreased when combined with Cholecalciferol.Approved, Nutraceutical
ClarithromycinThe metabolism of Montelukast can be decreased when combined with Clarithromycin.Approved
ClemastineThe metabolism of Montelukast can be decreased when combined with Clemastine.Approved
ClotrimazoleThe metabolism of Montelukast can be decreased when combined with Clotrimazole.Approved, Vet Approved
CobicistatThe metabolism of Montelukast can be decreased when combined with Cobicistat.Approved
ConivaptanThe serum concentration of Montelukast can be increased when it is combined with Conivaptan.Approved, Investigational
CrizotinibThe metabolism of Montelukast can be decreased when combined with Crizotinib.Approved
CyclosporineThe metabolism of Montelukast can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
DabrafenibThe serum concentration of Montelukast can be decreased when it is combined with Dabrafenib.Approved
DarunavirThe metabolism of Montelukast can be decreased when combined with Darunavir.Approved
DasatinibThe serum concentration of Montelukast can be increased when it is combined with Dasatinib.Approved, Investigational
DeferasiroxThe serum concentration of Montelukast can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe metabolism of Montelukast can be decreased when combined with Delavirdine.Approved
DexamethasoneThe serum concentration of Montelukast can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DihydroergotamineThe metabolism of Montelukast can be decreased when combined with Dihydroergotamine.Approved
DiltiazemThe metabolism of Montelukast can be decreased when combined with Diltiazem.Approved
DoxycyclineThe metabolism of Montelukast can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronedaroneThe metabolism of Montelukast can be decreased when combined with Dronedarone.Approved
EfavirenzThe serum concentration of Montelukast can be decreased when it is combined with Efavirenz.Approved, Investigational
EnzalutamideThe serum concentration of Montelukast can be decreased when it is combined with Enzalutamide.Approved
ErythromycinThe metabolism of Montelukast can be decreased when combined with Erythromycin.Approved, Vet Approved
Eslicarbazepine acetateThe serum concentration of Montelukast can be decreased when it is combined with Eslicarbazepine acetate.Approved
EtravirineThe serum concentration of Montelukast can be decreased when it is combined with Etravirine.Approved
FloxuridineThe metabolism of Montelukast can be decreased when combined with Floxuridine.Approved
FluconazoleThe metabolism of Montelukast can be decreased when combined with Fluconazole.Approved
FluorouracilThe metabolism of Montelukast can be decreased when combined with Fluorouracil.Approved
FluvastatinThe metabolism of Montelukast can be decreased when combined with Fluvastatin.Approved
FluvoxamineThe metabolism of Montelukast can be decreased when combined with Fluvoxamine.Approved, Investigational
FosamprenavirThe metabolism of Montelukast can be decreased when combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Montelukast can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe metabolism of Montelukast can be increased when combined with Fosphenytoin.Approved
Fusidic AcidThe serum concentration of Montelukast can be increased when it is combined with Fusidic Acid.Approved
GemfibrozilThe serum concentration of Montelukast can be increased when it is combined with Gemfibrozil.Approved
IdelalisibThe serum concentration of Montelukast can be increased when it is combined with Idelalisib.Approved
ImatinibThe metabolism of Montelukast can be decreased when combined with Imatinib.Approved
IndinavirThe metabolism of Montelukast can be decreased when combined with Indinavir.Approved
IrbesartanThe metabolism of Montelukast can be decreased when combined with Irbesartan.Approved, Investigational
IsavuconazoniumThe metabolism of Montelukast can be decreased when combined with Isavuconazonium.Approved, Investigational
IsradipineThe metabolism of Montelukast can be decreased when combined with Isradipine.Approved
ItraconazoleThe metabolism of Montelukast can be decreased when combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Montelukast can be increased when it is combined with Ivacaftor.Approved
KetoconazoleThe metabolism of Montelukast can be decreased when combined with Ketoconazole.Approved, Investigational
LeflunomideThe metabolism of Montelukast can be decreased when combined with Leflunomide.Approved, Investigational
LopinavirThe metabolism of Montelukast can be decreased when combined with Lopinavir.Approved
LosartanThe metabolism of Montelukast can be decreased when combined with Losartan.Approved
LovastatinThe metabolism of Montelukast can be decreased when combined with Lovastatin.Approved, Investigational
LoxapineThe risk or severity of adverse effects can be increased when Montelukast is combined with Loxapine.Approved
LuliconazoleThe serum concentration of Montelukast can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Montelukast can be decreased when it is combined with Lumacaftor.Approved
MifepristoneThe serum concentration of Montelukast can be increased when it is combined with Mifepristone.Approved, Investigational
MitotaneThe serum concentration of Montelukast can be decreased when it is combined with Mitotane.Approved
ModafinilThe serum concentration of Montelukast can be decreased when it is combined with Modafinil.Approved, Investigational
NafcillinThe serum concentration of Montelukast can be decreased when it is combined with Nafcillin.Approved
NefazodoneThe metabolism of Montelukast can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe metabolism of Montelukast can be decreased when combined with Nelfinavir.Approved
NetupitantThe serum concentration of Montelukast can be increased when it is combined with Netupitant.Approved
NevirapineThe metabolism of Montelukast can be increased when combined with Nevirapine.Approved
NicardipineThe metabolism of Montelukast can be decreased when combined with Nicardipine.Approved
NicotineThe metabolism of Montelukast can be decreased when combined with Nicotine.Approved
NilotinibThe metabolism of Montelukast can be decreased when combined with Nilotinib.Approved, Investigational
OlaparibThe metabolism of Montelukast can be decreased when combined with Olaparib.Approved
OmeprazoleThe metabolism of Montelukast can be decreased when combined with Omeprazole.Approved, Investigational, Vet Approved
OsimertinibThe serum concentration of Montelukast can be increased when it is combined with Osimertinib.Approved
PalbociclibThe serum concentration of Montelukast can be increased when it is combined with Palbociclib.Approved
PentobarbitalThe metabolism of Montelukast can be increased when combined with Pentobarbital.Approved, Vet Approved
PhenobarbitalThe metabolism of Montelukast can be increased when combined with Phenobarbital.Approved
PhenytoinThe metabolism of Montelukast can be increased when combined with Phenytoin.Approved, Vet Approved
PosaconazoleThe metabolism of Montelukast can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PrimidoneThe metabolism of Montelukast can be increased when combined with Primidone.Approved, Vet Approved
PyrimethamineThe metabolism of Montelukast can be decreased when combined with Pyrimethamine.Approved, Vet Approved
QuinineThe metabolism of Montelukast can be decreased when combined with Quinine.Approved
RanolazineThe metabolism of Montelukast can be decreased when combined with Ranolazine.Approved, Investigational
RifabutinThe metabolism of Montelukast can be increased when combined with Rifabutin.Approved
RifampicinThe metabolism of Montelukast can be increased when combined with Rifampicin.Approved
RifapentineThe metabolism of Montelukast can be increased when combined with Rifapentine.Approved
RitonavirThe metabolism of Montelukast can be decreased when combined with Ritonavir.Approved, Investigational
SaquinavirThe metabolism of Montelukast can be decreased when combined with Saquinavir.Approved, Investigational
SecobarbitalThe metabolism of Montelukast can be increased when combined with Secobarbital.Approved, Vet Approved
SildenafilThe metabolism of Montelukast can be decreased when combined with Sildenafil.Approved, Investigational
SiltuximabThe serum concentration of Montelukast can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Montelukast can be increased when it is combined with Simeprevir.Approved
SorafenibThe metabolism of Montelukast can be decreased when combined with Sorafenib.Approved, Investigational
St. John's WortThe serum concentration of Montelukast can be decreased when it is combined with St. John's Wort.Nutraceutical
StiripentolThe serum concentration of Montelukast can be increased when it is combined with Stiripentol.Approved
SulfadiazineThe metabolism of Montelukast can be decreased when combined with Sulfadiazine.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Montelukast can be decreased when combined with Sulfamethoxazole.Approved
SulfisoxazoleThe metabolism of Montelukast can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
TelaprevirThe metabolism of Montelukast can be decreased when combined with Telaprevir.Approved
TelithromycinThe metabolism of Montelukast can be decreased when combined with Telithromycin.Approved
TicagrelorThe metabolism of Montelukast can be decreased when combined with Ticagrelor.Approved
TiclopidineThe metabolism of Montelukast can be decreased when combined with Ticlopidine.Approved
TocilizumabThe serum concentration of Montelukast can be decreased when it is combined with Tocilizumab.Approved
TolbutamideThe metabolism of Montelukast can be decreased when combined with Tolbutamide.Approved
TrimethoprimThe metabolism of Montelukast can be decreased when combined with Trimethoprim.Approved, Vet Approved
Valproic AcidThe metabolism of Montelukast can be decreased when combined with Valproic Acid.Approved, Investigational
ValsartanThe metabolism of Montelukast can be decreased when combined with Valsartan.Approved, Investigational
VenlafaxineThe metabolism of Montelukast can be decreased when combined with Venlafaxine.Approved
VerapamilThe metabolism of Montelukast can be decreased when combined with Verapamil.Approved
VoriconazoleThe metabolism of Montelukast can be decreased when combined with Voriconazole.Approved, Investigational
ZafirlukastThe metabolism of Montelukast can be decreased when combined with Zafirlukast.Approved, Investigational
ZiprasidoneThe metabolism of Montelukast can be decreased when combined with Ziprasidone.Approved
Food Interactions
  • Take without regard to meals.
References
Synthesis Reference

Evgeny Shapiro, Ronit Yahalomi, Valerie Niddam-Hildesheim, Greta Sterimbaum, Kobi Chen, “Processes for preparing montelukast sodium.” U.S. Patent US20050256156, issued November 17, 2005.

US20050256156
General ReferencesNot Available
External Links
ATC CodesR03DC53R03DC03
AHFS Codes
  • 48:10.24
PDB EntriesNot Available
FDA labelDownload (503 KB)
MSDSNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9947
Blood Brain Barrier+0.9311
Caco-2 permeable+0.5428
P-glycoprotein substrateSubstrate0.6839
P-glycoprotein inhibitor INon-inhibitor0.8863
P-glycoprotein inhibitor IINon-inhibitor0.9154
Renal organic cation transporterNon-inhibitor0.8395
CYP450 2C9 substrateNon-substrate0.6967
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.7284
CYP450 1A2 substrateNon-inhibitor0.6266
CYP450 2C9 inhibitorNon-inhibitor0.7177
CYP450 2D6 inhibitorNon-inhibitor0.8436
CYP450 2C19 inhibitorNon-inhibitor0.5777
CYP450 3A4 inhibitorNon-inhibitor0.6759
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.5515
Ames testNon AMES toxic0.7532
CarcinogenicityNon-carcinogens0.9126
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.6488 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.985
hERG inhibition (predictor II)Non-inhibitor0.7932
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Merck research laboratories div merck co inc
  • Merck and co inc
Packagers
Dosage forms
FormRouteStrength
Tablet, chewableOral4 mg/1
Tablet, chewableOral5 mg/1
Tablet, film coatedOral10 mg/1
GranuleOral4 mg/500mg
GranuleOral4 mg/1
TabletOral10 mg/1
Tablet, coatedOral10 mg/1
GranuleOral10 mg/1
GranuleOral4 mg
GranuleOral5 mg/1
TabletOral10 mg
Tablet, chewableOral4 mg
Tablet, chewableOral5 mg
Prices
Unit descriptionCostUnit
Singulair 30 4 mg Chew Tabs Bottle145.91USD bottle
Singulair 30 4 mg Packets Packet145.91USD packet
Singulair 30 5 mg Chew Tabs Bottle145.91USD bottle
Singulair 10 mg tablet4.77USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2053209 No1998-12-082011-10-10Canada
CA2179407 No2009-03-172014-12-22Canada
US5565473 No1995-08-032012-08-03Us
US8007830 No2002-10-242022-10-24Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
logP7.9Not Available
Predicted Properties
PropertyValueSource
Water Solubility8.2e-06 mg/mLALOGPS
logP7.25ALOGPS
logP8.49ChemAxon
logS-7.8ALOGPS
pKa (Strongest Acidic)4.4ChemAxon
pKa (Strongest Basic)3.12ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area70.42 Å2ChemAxon
Rotatable Bond Count12ChemAxon
Refractivity169.5 m3·mol-1ChemAxon
Polarizability66.36 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as linear 1,3-diarylpropanoids. These are organic compounds with a structure based on a C6-C3-C6 skeleton, where the two benzene rings are not linked together.
KingdomOrganic compounds
Super ClassPhenylpropanoids and polyketides
ClassLinear 1,3-diarylpropanoids
Sub ClassNot Available
Direct ParentLinear 1,3-diarylpropanoids
Alternative Parents
Substituents
  • Linear 1,3-diarylpropanoid
  • Chloroquinoline
  • Quinoline
  • Phenylpropane
  • Styrene
  • Thia fatty acid
  • Fatty acyl
  • Benzenoid
  • Pyridine
  • Aryl halide
  • Aryl chloride
  • Heteroaromatic compound
  • Tertiary alcohol
  • Azacycle
  • Organoheterocyclic compound
  • Dialkylthioether
  • Sulfenyl compound
  • Thioether
  • Monocarboxylic acid or derivatives
  • Carboxylic acid
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Aromatic alcohol
  • Organosulfur compound
  • Organooxygen compound
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Carbonyl group
  • Alcohol
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Leukotriene receptor activity
Specific Function:
Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affini...
Gene Name:
CYSLTR1
Uniprot ID:
Q9Y271
Molecular Weight:
38540.55 Da
References
  1. Nayak A: A review of montelukast in the treatment of asthma and allergic rhinitis. Expert Opin Pharmacother. 2004 Mar;5(3):679-86. [PubMed:15013935 ]
  2. Zhang YJ, Zhang L, Wang SB, Shen HH, Wei EQ: Montelukast modulates lung CysLT(1) receptor expression and eosinophilic inflammation in asthmatic mice. Acta Pharmacol Sin. 2004 Oct;25(10):1341-6. [PubMed:15456537 ]
  3. Hamacher J, Eichert K, Braun C, Grebe T, Strub A, Lucas R, Eltze M, Wendel A: Montelukast exerts no acute direct effect on NO synthases. Pulm Pharmacol Ther. 2007;20(5):525-33. Epub 2006 May 19. [PubMed:16815057 ]
  4. Langlois A, Ferland C, Tremblay GM, Laviolette M: Montelukast regulates eosinophil protease activity through a leukotriene-independent mechanism. J Allergy Clin Immunol. 2006 Jul;118(1):113-9. Epub 2006 May 19. [PubMed:16815146 ]
  5. Alfieri AB, Tramontana M, Cialdai C, Lecci A, Giuliani S, Crea A, Manzini S, Maggi CA: Heterogeneous effect of leucotriene CysLT1 receptor antagonists on antigen-induced motor and inflammatory responses in guinea-pig airways. Auton Autacoid Pharmacol. 2007 Jan;27(1):39-46. [PubMed:17199874 ]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
other/unknown
General Function:
Iron ion binding
Specific Function:
Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.
Gene Name:
ALOX5
Uniprot ID:
P09917
Molecular Weight:
77982.595 Da
References
  1. Ramires R, Caiaffa MF, Tursi A, Haeggstrom JZ, Macchia L: Novel inhibitory effect on 5-lipoxygenase activity by the anti-asthma drug montelukast. Biochem Biophys Res Commun. 2004 Nov 12;324(2):815-21. [PubMed:15474500 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Schoch GA, Yano JK, Sansen S, Dansette PM, Stout CD, Johnson EF: Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid. J Biol Chem. 2008 Jun 20;283(25):17227-37. doi: 10.1074/jbc.M802180200. Epub 2008 Apr 15. [PubMed:18413310 ]
  2. Walsky RL, Gaman EA, Obach RS: Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78. [PubMed:15601807 ]
  3. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  4. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Prostaglandin-endoperoxide synthase activity
Specific Function:
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the gener...
Gene Name:
PTGS1
Uniprot ID:
P23219
Molecular Weight:
68685.82 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.
Gene Name:
CYP2A6
Uniprot ID:
P11509
Molecular Weight:
56501.005 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.
Gene Name:
SLCO2B1
Uniprot ID:
O94956
Molecular Weight:
76709.98 Da
References
  1. Mougey EB, Feng H, Castro M, Irvin CG, Lima JJ: Absorption of montelukast is transporter mediated: a common variant of OATP2B1 is associated with reduced plasma concentrations and poor response. Pharmacogenet Genomics. 2009 Feb;19(2):129-38. doi: 10.1097/FPC.0b013e32831bd98c. [PubMed:19151602 ]
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Drug created on June 13, 2005 07:24 / Updated on December 05, 2016 02:42