Cycloparaffins

Alicyclic hydrocarbons in which three or more of the carbon atoms in each molecule are united in a ring structure and each of the ring carbon atoms is joined to two hydrogen atoms or alkyl groups. The simplest members are cyclopropane (C3H6), cyclobutane (C4H8), cyclohexane (C6H12), and derivatives of these such as methylcyclohexane (C6H11CH3). (From Sax, et al., Hawley's Condensed Chemical Dictionary, 11th ed)
DrugDrug NameDrug Indication
DB00162Vitamin AFor the treatment of vitamin A deficiency.
DB00193TramadolTramadol is approved for the management of moderate to severe pain in adults.[FDA label] As an off-label indication, tramadol has been investigated to be used for the treatment of premature ejaculation.[A173986]
DB00285VenlafaxineVenlafaxine is indicated in the management of major depressive disorder (MDD), generalized anxiety disorder (GAD), social anxiety disorder (social phobia), and panic disorder with or without agoraphobia. Venlafaxine is also used off-label for prophylaxis of migraine headaches [A177229], for reduction of vasomotor symptoms associated with menopause [A177238], and for management of neuropathic pain (although there is only minimal evidence of efficacy for this condition) [A177232]. It is also considered a second-line option for management of obsessive-compulsive disorder (OCD) [A177226, A177235].
DB00302Tranexamic acidFor use in patients with hemophilia for short term use (two to eight days) to reduce or prevent hemorrhage and reduce the need for replacement therapy during and following tooth extraction. It can also be used for excessive bleeding in menstruation, surgery, or trauma cases.
DB00348NitisinoneUsed as an adjunct to dietary restriction of tyrosine and phenylalanine in the treatment of hereditary tyrosinemia type 1.
DB00459AcitretinFor the treatment of severe psoriasis in adults.
DB00466PicrotoxinUsed internally for relieving respiratory distress. Also for use as an antidote in poisoning by CNS depressants, especially barbiturates.
DB00473HexylcaineUsed as a local anesthetic for surface application, infiltration or nerve block
DB00478RimantadineFor the prophylaxis and treatment of illness caused by various strains of influenza A virus in adults.
DB00523AlitretinoinFor topical treatment of cutaneous lesions in patients with AIDS-related Kaposi's sarcoma.
DB00640AdenosineUsed as an initial treatment for the termination of paroxysmal supraventricular tachycardia (PVST), including that associated with accessory bypass tracts, and is a drug of choice for terminating stable, narrow-complex supraventricular tachycardias (SVT). Also used as an adjunct to thallous chloride TI 201 myocardial perfusion scintigraphy (thallium stress test) in patients who are unable to exercise adequately, as well as an adjunct to vagal maneuvers and clinical assessment to establish a specific diagnosis of undefined, stable, narrow-complex SVT.
DB00731NateglinideFor the treatment of non-insulin dependent-diabetes mellitus in conjunction with diet and exercise.
DB00755TretinoinFor the the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant); For the topical treatment of acne vulgaris, flat warts and other skin conditions (psoriasis, ichthyosis congenita, icthyosis vulgaris, lamellar icthyosis, keratosis palmaris et plantaris, epidermolytic hyperkeratosis, senile comedones, senile keratosis, keratosis follicularis (Darier's disease), and basal cell carcinomas.); For palliative therapy to improve fine wrinkling, mottled hyperpigmentation, roughness associated with photodamage.
DB00804DicyclomineFor the treatment of functional bowel/irritable bowel syndrome including Colicky abdominal pain; diverticulitis
DB00915AmantadineFor the chemoprophylaxis, prophylaxis, and treatment of signs and symptoms of infection caused by various strains of influenza A virus. Also for the treatment of parkinsonism and drug-induced extrapyramidal reactions.
DB00926EtretinateFor the treatment of severe psoriasis in adults.
DB00982IsotretinoinIsotretinoin is indicated to treat severe recalcitrant nodular acne and patients ≥12 years enrolled in the iPLEDGE program.[Label,L6579]
DB00996GabapentinFor the management of postherpetic neuralgia in adults and as adjunctive therapy in the treatment of partial seizures with and without secondary generalization in patients over 12 years of age with epilepsy.
DB01105SibutramineFor the treatment of obesity.
DB01221KetamineKetamine is indicated as an anesthetic agent for recommended diagnostic and surgical procedures. If skeletal muscle relaxation is needed, it should be combined with a muscle relaxant. If the surgical procedure involves visceral pain, it should be supplemented with an agent that obtunds visceral pain. Ketamine can be used for induction of anesthesia prior other general anesthetic agents and as a supplement of low potency agents.[L1336, FDA label] Reports have indicated a potential use of ketamine as a therapeutic tool for the management of depression when administered in lower doses.[A31873] These reports have increased the interest for ketamine in this area and several clinical trials are launched for this indication.[L1337, A31874]
DB01229PaclitaxelUsed in the treatment of Kaposi's sarcoma and cancer of the lung, ovarian, and breast. Abraxane® is specfically indicated for the treatment of metastatic breast cancer and locally advanced or metastatic non-small cell lung cancer.
DB01248DocetaxelFor the treatment of patients with locally advanced or metastatic breast cancer after failure of prior chemotherapy. Also used as a single agent in the treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of prior platinum-based chemotherapy. It is also used in combination with prednisone, in the treatment of patients with androgen independent (hormone refractory) metastatic prostate cancer. Furthermore, docetaxel has uses in the treatment of gastric adenocarinoma and head and neck cancer.
DB015061-PhenylcyclohexylamineNot Available
DB01597CilastatinCombined intravenously with imipenem in order to protect it from dehydropeptidase and prolong its antibacterial effect.
DB01656RoflumilastRoflumilast is indicated as a treatment to reduce the risk of COPD exacerbations in patients with severe COPD associated with chronic bronchitis and a history of exacerbations. Roflumilast is not a bronchodilator and is not indicated for the relief of acute bronchospasm.
DB02054GabaculineNot Available
DB02060CyclohexanoneNot Available
DB02125AdamantanoneNot Available
DB02640FumagillinNot Available
DB026994-OxoretinolNot Available
DB02793Isochorismic AcidNot Available
DB02877Arotinoid acidNot Available
DB03001PeridininNot Available
DB03460ViolaxanthinNot Available
DB03627AdamantaneNot Available
DB03703CyclohexanolNot Available
DB03849CilomilastInvestigated for use/treatment in chronic obstructive pulmonary disease (COPD).
DB03852EucalyptolNot Available
DB038683-Dehydroquinic AcidNot Available
DB04328Shikimate-3-PhosphateNot Available
DB043473-DehydroshikimateNot Available
DB04620CycloleucineNot Available
DB04835MaravirocFor treatment-experienced adult patients infected with only CCR5-tropic HIV-1 detectable, who have evidence of viral replication and HIV-1 strains resistant to multiple antiretroviral agents.
DB04876VildagliptinUsed to reduce hyperglycemia in type 2 diabetes mellitus.
DB04878VogliboseFor the treatment of diabetes. It is specifically used for lowering post-prandial blood glucose levels thereby reducing the risk of macrovascular complications.
DB04926NeramexaneInvestigated for use/treatment in alzheimer's disease, hearing loss, and pain (acute or chronic).
DB05009ApadenosonInvestigated for use/treatment in cardiovascular disorders and inflammatory disorders (unspecified).
DB05076FenretinideInvestigated for use/treatment in macular degeneration.
DB05186SQ-109Investigated for use/treatment in bacterial infection, infectious and parasitic disease (unspecified), and tuberculosis.
DB05191Atl146eInvestigated for use/treatment in inflammatory disorders (unspecified).
DB05297Paclitaxel docosahexaenoic acidInvestigated for use/treatment in breast cancer, colorectal cancer, gastric cancer, kidney cancer, lung cancer, pancreatic cancer, prostate cancer, and skin cancer.
DB05653IRX-5183Investigated for use/treatment in adverse effects (chemotherapy) and blood (blood forming organ disorders, unspecified).
DB05792ArylacenamideInvestigated for use/treatment in cancer/tumors (unspecified), immunosuppressive, and prostate cancer.
DB05842AI-850Investigated for use/treatment in breast cancer and solid tumors.
DB05974TranscrocetinateInvestigated for use/treatment in cancer/tumors (unspecified), hemorrhage, hypoxia, respiratory failure, and strokes.
DB06171Paclitaxel trevatideInvestigated for use/treatment in brain cancer.
DB06200TedisamilInvestigated for use/treatment in arrhythmia, atrial fibrillation, and angina.
DB06335SaxagliptinTreatment of type 2 diabetes mellitus to improve glycemic control in combination with other agents or as monotherapy.
DB06345AR-9281Investigated for use/treatment in hypertension.
DB06543AstaxanthinInvestigated for use/treatment in eye disorders/infections, cancer/tumors (unspecified), and asthma.
DB06614PeramivirInvestigated for use/treatment in influenza.
DB06700DesvenlafaxineDesvenlafaxine is indicated for the treatment of major depressive disorder in adults[A6990,A6991,Label].
DB06742AmbroxolAmbroxol is indicated for secretolytic therapy in bronchoplmonary diseaes with abnormal mucus secretion and transport. It allows the mucus to be more easily cleared and ease a patient's breathing.
DB06755Beta caroteneBeta-carotene is FDA approved to be used as a nutrient supplement and to be even added in infant formula as a source of vitamin A.[L2191] It is also approved to be used as a color additive for food products,[L2192] drugs (with the label of "only as a color additive")[L2193] and cosmetics.[L2194] It is used commonly for the reduction of photosensitivity in patients with erythropoietic protoporphyria and other photosensitivity diseases.[A32485]
DB06772CabazitaxelFor treatment of patients with hormone-refractory metastatic prostate cancer previously treated with a docetaxel-containing treatment regimen.
DB06799MethenamineFor prophylactic or suppressive treatment of frequently recurring urinary tract infections when long-term therapy is considered necessary. This drug is not used to treat infection and should only be used after appropriate eradication of infection with antimicrobial agents.
DB070313-Fluoro-4-{[(2R)-2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)acetyl]amino}benzoic acidNot Available
DB073421-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanoneNot Available
DB08407PLATENSIMYCINNot Available
DB08427PREPHENIC ACIDNot Available
DB08455Ro 12-7310Not Available
DB08918LevomilnacipranLevomilnacipran is a serotonin and norepinephrine reuptake inhibitor and is indicated for the treatment of major depressive disorder (MDD).
DB08921(4R)-limoneneNot Available
DB08999CyclopentamineNot Available
DB09019BromhexineNot Available
DB09071TasimelteonTasimelteon is indicated for the treatment of Non-24-Hour Sleep-Wake Disorder (N24HSWD).
DB11176ZeaxanthinNot Available
DB11186PentoxyverineIndicated as a cough suppressant to relieve cough caused by the common cold, flu, bronchitis, and sinusitis [A32160].
DB11231LycopeneNot Available
DB11549TiletamineNot Available
DB11623CandoxatrilatNot Available
DB11669OrtataxelNot Available
DB11708PeficitinibNot Available
DB11711NavarixinNot Available
DB11759PevonedistatNot Available
DB11798TanzisertibNot Available
DB11809ArtefenomelNot Available
DB11874CrocinNot Available
DB11954LomibuvirNot Available
DB12019TesetaxelNot Available
DB12029Chlorogenic AcidNot Available
DB12032AtagabalinNot Available
DB12112Zuretinol acetateNot Available
DB12168MK-0557Not Available
DB12173DiphencyproneNot Available
DB12201PF-03654746Not Available
DB12223Squaric Acid Dibutyl EsterNot Available
DB12270LosmapimodNot Available
DB12305DasotralineNot Available
DB12334MilataxelNot Available
DB12360PF-03654764Not Available
DB12380GDC-0152Not Available
DB12501ABT-384Not Available
DB12556MK-5108Not Available
DB12594AZD-9056Not Available
DB12619BMS-188797Not Available
DB12633BMS-184476Not Available
DB12671BeloranibNot Available
DB12764ABC-294640Not Available
DB12984LarotaxelNot Available
DB13012AQX-1125Not Available
DB13049LobaplatinNot Available
DB13096GacyclidineNot Available
DB13141Ambroxol acefyllinateNot Available
DB13146Fluciclovine (18F)Fluciclovine is indicated as a detection agent for positron emission tomography (PET) in men with suspected prostate cancer recurrence based on elevated blood prostate specific antigen (PSA) levels following prior treatment.[A31388] The overexpression of L-type amino acid transporters such as LAT1 and LAT3 that mediate the uptake of essential amino acids has been extensively reported as a tumoral mechanism of cell growth.[A31389]
DB13163Terpin hydrateTerpin hydrate is used in the treatment of acute and chronic bronchitis, pneumonia, bronchiectasis, chronic obstructive pulmonary disease, infectious and inflammatory diseases of the upper respiratory tract.
DB13239NeltenexineNot Available
DB13288TromantadineNot Available
DB13329GuaiazulenNot Available
DB13368MotretinideNot Available
DB13488BencyclaneNot Available
DB13496IprindoleNot Available
DB13581RociverineNot Available
DB13656EberconazoleNot Available
DB13787TilidineNot Available
DB13809Paclitaxel poliglumexNot Available
DB13984CyclopropaneNot Available
DB1409713-cis-12-(3'-Carboxyphenyl)retinoic acidNot Available
DB14198Quaternium-15Quaternium-15 is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6 years of age and older.
DB00137LuteinXanthophylls are taken for nutritional supplementation, and also for treating dietary shortage or imbalance.
DB02600Oseltamivir acidNot Available
DB08633TNP-470Not Available
DB14802ONO-2952Not Available
DB14979MartinostatNot Available
DB15117TransfluthrinNot Available
DB15201NorbixinNot Available
DB15384SimotaxelNot Available
DB15462FucoxanthinNot Available
DrugDrug NameTargetType
DB00162Vitamin ARetinol dehydrogenase 12target
DB00162Vitamin ARetinol-binding protein 1target
DB00162Vitamin A11-cis retinol dehydrogenasetarget
DB00162Vitamin ARetinol dehydrogenase 13target
DB00162Vitamin ARetinol-binding protein 3target
DB00162Vitamin ARetinol-binding protein 5carrier
DB00162Vitamin ARetinoid-binding protein 7carrier
DB00162Vitamin ARetinol-binding protein 4carrier
DB00162Vitamin ARetinol-binding protein 2carrier
DB00162Vitamin ARetinal dehydrogenase 2target
DB00162Vitamin ARetinal dehydrogenase 1target
DB00162Vitamin ARetinaldehyde-binding protein 1target
DB00162Vitamin ALecithin retinol acyltransferasetarget
DB00162Vitamin AShort-chain dehydrogenase/reductase 3target
DB00162Vitamin AAldehyde dehydrogenase family 1 member A3target
DB00162Vitamin AAll-trans-retinol 13,14-reductasetarget
DB00162Vitamin ARetinol dehydrogenase 11target
DB00162Vitamin ADehydrogenase/reductase SDR family member 4target
DB00162Vitamin ARetinol dehydrogenase 14target
DB00162Vitamin ARetinol dehydrogenase 8target
DB00162Vitamin ACytochrome P450 1A1enzyme
DB00162Vitamin ACytochrome P450 26A1enzyme
DB00162Vitamin AApolipoprotein Dtarget
DB00162Vitamin AHematopoietic prostaglandin D synthasetarget
DB00162Vitamin ASerum albumincarrier
DB00193TramadolMu-type opioid receptortarget
DB00193TramadolSodium-dependent noradrenaline transportertarget
DB00193Tramadol5-hydroxytryptamine receptor 2Ctarget
DB00193TramadolKappa-type opioid receptortarget
DB00193TramadolSodium-dependent serotonin transportertarget
DB00193TramadolCytochrome P450 2D6enzyme
DB00193TramadolDelta-type opioid receptortarget
DB00193TramadolCytochrome P450 3A4enzyme
DB00193TramadolCytochrome P450 2B6enzyme
DB00193TramadolGlutamate receptor ionotropic, NMDA 3Atarget
DB00193TramadolAlpha-7 nicotinic cholinergic receptor subunittarget
DB00193TramadolMuscarinic acetylcholine receptor M3target
DB00193TramadolMuscarinic acetylcholine receptor M1target
DB00193TramadolUDP-glucuronosyltransferase 1-1enzyme
DB00193TramadolMultidrug resistance protein 1transporter
DB00285VenlafaxineSodium-dependent serotonin transportertarget
DB00285VenlafaxineSodium-dependent noradrenaline transportertarget
DB00285VenlafaxineCytochrome P450 2D6enzyme
DB00285VenlafaxineCytochrome P450 3A4enzyme
DB00285VenlafaxineSodium-dependent dopamine transportertarget
DB00285VenlafaxineMultidrug resistance protein 1transporter
DB00285VenlafaxineATP-binding cassette sub-family G member 2transporter
DB00302Tranexamic acidPlasminogentarget
DB00302Tranexamic acidSolute carrier family 15 member 2transporter
DB00348Nitisinone4-hydroxyphenylpyruvate dioxygenasetarget
DB00459AcitretinRetinoic acid receptor alphatarget
DB00459AcitretinRetinoic acid receptor RXR-betatarget
DB00459AcitretinRetinoic acid receptor gammatarget
DB00459AcitretinRetinoic acid receptor betatarget
DB00459AcitretinRetinoic acid receptor RXR-gammatarget
DB00459AcitretinRetinoic acid receptor RXR-alphatarget
DB00459AcitretinSerum albumincarrier
DB00459AcitretinRetinol-binding protein 1target
DB00459AcitretinCytochrome P450 26A1enzyme
DB00466PicrotoxinGamma-aminobutyric acid receptor subunit rho-1target
DB00466PicrotoxinGamma-aminobutyric acid receptor subunit alpha-1target
DB00466PicrotoxinGlycine receptor subunit alpha-2target
DB00466PicrotoxinGlycine receptor subunit alpha-3target
DB00466PicrotoxinCytochrome P450 1A1enzyme
DB00466PicrotoxinGlutamine synthetaseenzyme
DB00466PicrotoxinGlycine receptor subunit alpha-1target
DB00473HexylcaineSodium channel protein type 5 subunit alphatarget
DB00473HexylcaineSodium channel protein type 10 subunit alphatarget
DB00478RimantadineMatrix protein 2target
DB00523AlitretinoinRetinoic acid receptor alphatarget
DB00523AlitretinoinRetinoic acid receptor RXR-betatarget
DB00523AlitretinoinRetinoic acid receptor gammatarget
DB00523AlitretinoinRetinoic acid receptor betatarget
DB00523AlitretinoinRetinoic acid receptor RXR-gammatarget
DB00523AlitretinoinRetinoic acid receptor RXR-alphatarget
DB00523AlitretinoinCellular retinoic acid-binding protein 2carrier
DB00523AlitretinoinCellular retinoic acid-binding protein 1carrier
DB00523AlitretinoinMultidrug resistance protein 1transporter
DB00523AlitretinoinInsulin-like growth factor-binding protein 3target
DB00523AlitretinoinPregnancy-specific beta-1-glycoprotein 5target
DB00523AlitretinoinCytochrome P450 26C1target
DB00640AdenosineAdenosine receptor A3target
DB00640AdenosineAdenosine deaminaseenzyme
DB00640AdenosineAdenosine kinaseenzyme
DB00640AdenosineAdenosine receptor A1target
DB00640AdenosineAdenosine receptor A2atarget
DB00640AdenosineAdenosine receptor A2btarget
DB00640AdenosineSolute carrier family 28 member 3transporter
DB00731NateglinideATP-binding cassette sub-family C member 8target
DB00731NateglinideCytochrome P450 3A4enzyme
DB00731NateglinideCytochrome P450 2C9enzyme
DB00731NateglinidePeroxisome proliferator-activated receptor gammatarget
DB00731NateglinideCytochrome P450 3A5enzyme
DB00731NateglinideCytochrome P450 3A7enzyme
DB00731NateglinideSolute carrier family 15 member 1transporter
DB00731NateglinideSolute carrier family 15 member 2transporter
DB00731NateglinideSolute carrier family 22 member 6transporter
DB00731NateglinideMonocarboxylate transporter 1transporter
DB00731NateglinideProstaglandin G/H synthase 1enzyme
DB00731NateglinideUDP-glucuronosyltransferase 1-9enzyme
DB00731NateglinideCytochrome P450 2D6enzyme
DB00731NateglinideMultidrug resistance-associated protein 4transporter
DB00731NateglinideSerum albumincarrier
DB00731NateglinideAlpha-1-acid glycoprotein 1carrier
DB00755TretinoinRetinoic acid receptor gammatarget
DB00755TretinoinRetinoic acid receptor RXR-betatarget
DB00755TretinoinRetinal dehydrogenase 1target
DB00755TretinoinRetinoic acid-induced protein 3target
DB00755TretinoinRetinoic acid receptor RXR-gammatarget
DB00755TretinoinNuclear receptor subfamily 0 group B member 1target
DB00755TretinoinRetinal dehydrogenase 2target
DB00755TretinoinRetinoic acid receptor responder protein 1target
DB00755TretinoinCytochrome P450 2C8enzyme
DB00755TretinoinCellular retinoic acid-binding protein 1transporter
DB00755TretinoinCellular retinoic acid-binding protein 2transporter
DB00755TretinoinCytochrome P450 2B6enzyme
DB00755TretinoinCytochrome P450 3A4enzyme
DB00755TretinoinCytochrome P450 3A5enzyme
DB00755TretinoinCytochrome P450 2A6enzyme
DB00755TretinoinCytochrome P450 3A7enzyme
DB00755TretinoinCytochrome P450 2C18enzyme
DB00755TretinoinCytochrome P450 2C9enzyme
DB00755TretinoinCytochrome P450 4A11enzyme
DB00755TretinoinCytochrome P450 1A1enzyme
DB00755TretinoinRetinoic acid receptor alphatarget
DB00755TretinoinRetinoic acid receptor betatarget
DB00755TretinoinLipocalin-1target
DB00755TretinoinOdorant-binding protein 2atarget
DB00755TretinoinRetinol-binding protein 4target
DB00755TretinoinSerum albumincarrier
DB00755Tretinoin[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrialtarget
DB00755TretinoinRetinoic acid receptor RXR-alphatarget
DB00755TretinoinCytochrome P450 26A1target
DB00755TretinoinCytochrome P450 26B1target
DB00755TretinoinCytochrome P450 26C1target
DB00755TretinoinHematopoietic prostaglandin D synthasetarget
DB00804DicyclomineMuscarinic acetylcholine receptor M1target
DB00804DicyclomineMuscarinic acetylcholine receptor M2target
DB00804DicyclomineCytochrome P450 1A1enzyme
DB00915AmantadineD(2) dopamine receptortarget
DB00915AmantadineMatrix protein 2target
DB00915AmantadineAromatic-L-amino-acid decarboxylaseenzyme
DB00915AmantadineAmine oxidase [flavin-containing] Benzyme
DB00915AmantadineSolute carrier family 22 member 2transporter
DB00915AmantadineSolute carrier family 22 member 1transporter
DB00915AmantadineGlutamate receptor ionotropic, NMDA 3Atarget
DB00915AmantadineNeuronal acetylcholine receptor subunit alpha-7target
DB00915AmantadineNeuronal acetylcholine receptor subunit alpha-4target
DB00915AmantadineNeuronal acetylcholine receptor subunit alpha-3target
DB00926EtretinateRetinoic acid receptor alphatarget
DB00926EtretinateRetinoic acid receptor RXR-betatarget
DB00926EtretinateRetinoic acid receptor gammatarget
DB00926EtretinateRetinoic acid receptor betatarget
DB00926EtretinateRetinoic acid receptor RXR-gammatarget
DB00926EtretinateRetinoic acid receptor RXR-alphatarget
DB00926EtretinateCellular retinoic acid-binding protein 1carrier
DB00926EtretinateCytochrome P450 19A1enzyme
DB00926EtretinateCytochrome P450 26A1enzyme
DB00982IsotretinoinRetinoic acid receptor alphatarget
DB00982IsotretinoinSerum albumincarrier
DB00982IsotretinoinRetinoic acid receptor gammatarget
DB00982IsotretinoinCytochrome P450 3A4enzyme
DB00996GabapentinAdenosine receptor A1target
DB00996GabapentinVoltage-dependent N-type calcium channel subunit alpha-1Btarget
DB00996GabapentinVoltage-dependent calcium channel subunit alpha-2/delta-1target
DB00996GabapentinVoltage-dependent calcium channel subunit alpha-2/delta-2target
DB00996GabapentinBranched-chain-amino-acid aminotransferase, cytosolicenzyme
DB00996GabapentinNMDA receptortarget
DB00996GabapentinGamma-aminobutyric acid type B receptor subunit 1target
DB00996GabapentinGamma-aminobutyric acid type B receptor subunit 2target
DB00996GabapentinCytochrome P450 3A4enzyme
DB01105SibutramineSodium-dependent serotonin transportertarget
DB01105SibutramineSodium-dependent noradrenaline transportertarget
DB01105SibutramineCytochrome P450 3A4enzyme
DB01105SibutramineSodium-dependent dopamine transportertarget
DB01221KetamineGlutamate receptor ionotropic, NMDA 3Atarget
DB01221KetamineSubstance-P receptortarget
DB01221KetamineCytochrome P450 2B6enzyme
DB01221KetamineCytochrome P450 2C9enzyme
DB01221KetamineCytochrome P450 3A4enzyme
DB01221KetamineD(2) dopamine receptortarget
DB01221KetamineProstaglandin G/H synthase 1enzyme
DB01221KetamineCytochrome P450 2C8enzyme
DB01221KetamineDelta-type opioid receptortarget
DB01221KetamineSodium-dependent noradrenaline transportertarget
DB01221KetamineKappa-type opioid receptortarget
DB01221KetamineMu-type opioid receptortarget
DB01221KetamineMuscarinic acetylcholine receptortarget
DB01221Ketamine5-hydroxytryptamine receptor 2target
DB01221Ketamine5-hydroxytryptamine receptor 1target
DB01221Ketamine5-hydroxytryptamine receptor 3Atarget
DB01221KetamineAlpha-7 nicotinic cholinergic receptor subunittarget
DB01221KetamineCholinesterasetarget
DB01221KetamineNitric oxide synthase, braintarget
DB01229PaclitaxelApoptosis regulator Bcl-2target
DB01229PaclitaxelTubulin beta-1 chaintarget
DB01229PaclitaxelCytochrome P450 2C8enzyme
DB01229PaclitaxelCytochrome P450 3A4enzyme
DB01229PaclitaxelCytochrome P450 3A5enzyme
DB01229PaclitaxelCytochrome P450 3A7enzyme
DB01229PaclitaxelBile salt export pumptransporter
DB01229PaclitaxelMultidrug resistance protein 1transporter
DB01229PaclitaxelMultidrug resistance-associated protein 1transporter
DB01229PaclitaxelMultidrug resistance-associated protein 7transporter
DB01229PaclitaxelCytochrome P450 19A1enzyme
DB01229PaclitaxelCytochrome P450 1B1enzyme
DB01229PaclitaxelSolute carrier organic anion transporter family member 1B3transporter
DB01229PaclitaxelNuclear receptor subfamily 1 group I member 2target
DB01229PaclitaxelMicrotubule-associated protein 4target
DB01229PaclitaxelMicrotubule-associated protein 2target
DB01229PaclitaxelMicrotubule-associated protein tautarget
DB01229PaclitaxelATP-binding cassette sub-family G member 2transporter
DB01229PaclitaxelCanalicular multispecific organic anion transporter 1transporter
DB01248DocetaxelApoptosis regulator Bcl-2target
DB01248DocetaxelTubulin beta-1 chaintarget
DB01248DocetaxelCytochrome P450 3A4enzyme
DB01248DocetaxelCytochrome P450 3A5enzyme
DB01248DocetaxelCytochrome P450 3A7enzyme
DB01248DocetaxelMultidrug resistance protein 1transporter
DB01248DocetaxelMultidrug resistance-associated protein 7transporter
DB01248DocetaxelCytochrome P450 1B1enzyme
DB01248DocetaxelMicrotubule-associated protein 2target
DB01248DocetaxelMicrotubule-associated protein 4target
DB01248DocetaxelMicrotubule-associated protein tautarget
DB01248DocetaxelSolute carrier organic anion transporter family member 1B3transporter
DB01248DocetaxelSolute carrier family 22 member 7transporter
DB01248DocetaxelATP-binding cassette sub-family G member 2transporter
DB01248DocetaxelCanalicular multispecific organic anion transporter 1transporter
DB01248DocetaxelMultidrug resistance-associated protein 1transporter
DB01248DocetaxelNuclear receptor subfamily 1 group I member 2target
DB01597CilastatinDipeptidase 1target
DB01597CilastatinSolute carrier family 22 member 6transporter
DB01597CilastatinSolute carrier family 22 member 8transporter
DB01656RoflumilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Dtarget
DB01656RoflumilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
DB01656RoflumilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
DB01656RoflumilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Ctarget
DB01656RoflumilastCytochrome P450 3A4enzyme
DB02054GabaculineOrnithine aminotransferase, mitochondrialtarget
DB02054GabaculineGlutamate-1-semialdehyde 2,1-aminomutasetarget
DB02060CyclohexanonePentaerythritol tetranitrate reductasetarget
DB02125AdamantanoneCamphor 5-monooxygenasetarget
DB02640FumagillinMethionine aminopeptidase 2target
DB02793Isochorismic AcidPhenazine biosynthesis protein PhzDtarget
DB02877Arotinoid acidRetinoic acid receptor betatarget
DB03627AdamantaneCamphor 5-monooxygenasetarget
DB03703CyclohexanolAlcohol dehydrogenase 1Btarget
DB03849CilomilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Dtarget
DB03849CilomilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
DB038683-Dehydroquinic Acid3-dehydroquinate dehydratasetarget
DB04328Shikimate-3-Phosphate3-phosphoshikimate 1-carboxyvinyltransferasetarget
DB04328Shikimate-3-Phosphate3-phosphoshikimate 1-carboxyvinyltransferasetarget
DB043473-Dehydroshikimate3-dehydroquinate dehydratasetarget
DB043473-Dehydroshikimate3-dehydroquinate dehydratasetarget
DB04620CycloleucineGlutamate receptor ionotropic, NMDA 1target
DB04835MaravirocC-C chemokine receptor type 5target
DB04835MaravirocCytochrome P450 3A4enzyme
DB04876VildagliptinDipeptidyl peptidase 4target
DB04878VogliboseMaltase-glucoamylase, intestinaltarget
DB04926NeramexaneGlutamate receptor ionotropic, NMDA 3Atarget
DB05009ApadenosonAdenosine receptor A2atarget
DB05076FenretinideRetinol-binding protein 4carrier
DB05191Atl146eAdenosine receptor A2atarget
DB05297Paclitaxel docosahexaenoic acidApoptosis regulator Bcl-2target
DB05792ArylacenamideHCG20471, isoform CRA_ctarget
DB06335SaxagliptinDipeptidyl peptidase 4target
DB06335SaxagliptinCytochrome P450 3A4enzyme
DB06335SaxagliptinCytochrome P450 3A5enzyme
DB06335SaxagliptinMultidrug resistance-associated protein 1transporter
DB06335SaxagliptinSolute carrier organic anion transporter family member 4C1transporter
DB06335SaxagliptinSolute carrier family 22 member 8transporter
DB06345AR-9281Bifunctional epoxide hydrolase 2target
DB06543AstaxanthinNF-kappa-B inhibitor alphatarget
DB06614PeramivirNeuraminidasetarget
DB06614PeramivirNeuraminidasetarget
DB06614PeramivirNeuraminidasetarget
DB06700DesvenlafaxineCytochrome P450 3A4enzyme
DB06700DesvenlafaxineSodium-dependent serotonin transportertarget
DB06700DesvenlafaxineSodium-dependent noradrenaline transportertarget
DB06700DesvenlafaxineCytochrome P450 2D6enzyme
DB06700DesvenlafaxineSodium-dependent dopamine transportertarget
DB06742AmbroxolCytochrome P450 3A4enzyme
DB06755Beta caroteneBeta,beta-carotene 15,15'-dioxygenaseenzyme
DB06755Beta caroteneFree radicalstarget
DB06755Beta caroteneVery low-density lipoprotein receptorcarrier
DB06755Beta caroteneRetinol-binding protein 1carrier
DB06755Beta caroteneRetinol-binding protein 2carrier
DB06755Beta caroteneRetinol-binding protein 3carrier
DB06755Beta caroteneRetinol-binding protein 4carrier
DB06755Beta caroteneRetinol-binding protein 5carrier
DB06772CabazitaxelCytochrome P450 3A4enzyme
DB06772CabazitaxelCytochrome P450 3A5enzyme
DB06772CabazitaxelCytochrome P450 2C8enzyme
DB06772CabazitaxelMultidrug resistance protein 1transporter
DB06772CabazitaxelATP-binding cassette sub-family G member 2transporter
DB06772CabazitaxelTubulin alpha-4A chaintarget
DB06772CabazitaxelTubulin beta-1 chaintarget
DB06772CabazitaxelSolute carrier organic anion transporter family member 1B1transporter
DB06772CabazitaxelSolute carrier organic anion transporter family member 1B3transporter
DB070313-Fluoro-4-{[(2R)-2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)acetyl]amino}benzoic acidRetinoic acid receptor gammatarget
DB073421-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanoneHeme oxygenase 1target
DB08407PLATENSIMYCIN3-oxoacyl-[acyl-carrier-protein] synthase 2target
DB08427PREPHENIC ACIDChorismate mutase AroHtarget
DB08455Ro 12-7310Cellular retinoic acid-binding protein 2carrier
DB08918LevomilnacipranCytochrome P450 3A4enzyme
DB08918LevomilnacipranCytochrome P450 2C8enzyme
DB08918LevomilnacipranCytochrome P450 2C19enzyme
DB08918LevomilnacipranCytochrome P450 2D6enzyme
DB08918LevomilnacipranCytochrome P450 2J2enzyme
DB08918LevomilnacipranSodium-dependent serotonin transportertarget
DB08918LevomilnacipranSodium-dependent noradrenaline transportertarget
DB08918LevomilnacipranMultidrug resistance protein 1transporter
DB09071TasimelteonMelatonin receptor type 1Atarget
DB09071TasimelteonMelatonin receptor type 1Btarget
DB09071TasimelteonCytochrome P450 3A4enzyme
DB09071TasimelteonCytochrome P450 1A2enzyme
DB11186PentoxyverineSigma non-opioid intracellular receptor 1target
DB11186PentoxyverinePotassium voltage-gated channel subfamily H member 2target
DB11186PentoxyverineVoltage gated sodium channeltarget
DB11186PentoxyverineKappa-type opioid receptortarget
DB11186PentoxyverineMu-type opioid receptortarget
DB11623CandoxatrilatNeprilysintarget
DB12305DasotralineSodium-dependent dopamine transportertarget
DB12305DasotralineSodium-dependent serotonin transportertarget
DB12305DasotralineSodium-dependent noradrenaline transportertarget
DB12334MilataxelTubulin beta-1 chaintarget
DB12334MilataxelTubulin beta chaintarget
DB13141Ambroxol acefyllinateCYP3Aenzyme
DB13146Fluciclovine (18F)Neutral amino acid transporter B(0)target
DB13146Fluciclovine (18F)Y+L amino acid transporter 1target
DB13146Fluciclovine (18F)Cationic amino acid transporter 3target
DB13146Fluciclovine (18F)Glutamate (NMDA) receptortarget
DB13146Fluciclovine (18F)Glutamate receptor 1target
DB13146Fluciclovine (18F)Glutamate receptor 2target
DB13146Fluciclovine (18F)Glutamate receptor 3target
DB13146Fluciclovine (18F)Glutamate receptor 4target
DB13146Fluciclovine (18F)Multidrug resistance protein 1transporter
DB13146Fluciclovine (18F)Multidrug resistance-associated protein 4transporter
DB13488BencyclaneCytochrome P450 3A4enzyme
DB13581RociverineMuscarinic acetylcholine receptor M1target
DB13581RociverineMuscarinic acetylcholine receptor M2target
DB13581RociverineMuscarinic acetylcholine receptor M3target
DB13581RociverineMuscarinic acetylcholine receptor M4target
DB13581RociverineMuscarinic acetylcholine receptor M5target
DB00137LuteinSerum albumincarrier
DB02600Oseltamivir acidNeuraminidasetarget
DB08633TNP-470Methionine aminopeptidase 2target