Identification

Name
Oxandrolone
Accession Number
DB00621  (APRD01151)
Type
Small Molecule
Groups
Approved, Investigational
Description

A synthetic hormone with anabolic and androgenic properties. [PubChem]

Structure
Thumb
Synonyms
  • Ossandrolone
  • Oxandrolon
  • Oxandrolona
  • Oxandrolone
  • Oxandrolonum
  • Protivar
External IDs
CB 8075 / NSC-67068 / SC 11585 / SC-11585
Product Images
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
OxandroloneTablet2.5 mg/1OralWatson Pharmaceuticals2007-01-012016-03-01Us00591 3544 01 nlmimage10 a71b53da
OxandroloneTablet10 mg/1OralWatson Pharmaceuticals2007-01-012016-03-01Us
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
OxandroloneTablet10 mg/1OralA S Medication Solutions2007-08-202017-06-20Us
OxandroloneTablet2.5 mg/1OralUpsher Smith Laboratories, Llc2006-12-01Not applicableUs00245 0271 11 nlmimage10 283c9444
OxandroloneTablet10 mg/1OralAmerincan Health Packaging2015-03-30Not applicableUs
OxandroloneTablet10 mg/1OralPar Pharmaceutical2007-08-20Not applicableUs
OxandroloneTablet2.5 mg/1OralAmerincan Health Packaging2012-11-01Not applicableUs
OxandroloneTablet10 mg/1OralUpsher Smith Laboratories, Llc2007-03-22Not applicableUs
OxandroloneTablet2.5 mg/1OralPar Pharmaceutical2007-08-20Not applicableUs
International/Other Brands
Anavar (Pfizer Inc.) / Oxandrin (Savient Pharmaceuticals) / Xtendrol (Atlantis)
Categories
UNII
7H6TM3CT4L
CAS number
53-39-4
Weight
Average: 306.4397
Monoisotopic: 306.219494826
Chemical Formula
C19H30O3
InChI Key
QSLJIVKCVHQPLV-PEMPUTJUSA-N
InChI
InChI=1S/C19H30O3/c1-17-11-22-16(20)10-12(17)4-5-13-14(17)6-8-18(2)15(13)7-9-19(18,3)21/h12-15,21H,4-11H2,1-3H3/t12-,13+,14-,15-,17-,18-,19-/m0/s1
IUPAC Name
(1S,2S,7S,10R,11S,14S,15S)-14-hydroxy-2,14,15-trimethyl-4-oxatetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-5-one
SMILES

Pharmacology

Indication

Use to promote weight gain after weight loss following extensive surgery.

Structured Indications
Pharmacodynamics

Oxandrolone is an anabolic steroids indicated as adjunctive therapy to promote weight gain after weight loss following extensive surgery, chronic infections, or severe trauma, and in some patients who without definite pathophysiologic reasons fail to gain or to maintain normal weight, to offset the protein catabolism associated with prolonged administration of corticosteroids, and for the relief of the bone pain frequently accompanying osteoporosis. Anabolic steroids are synthetic derivatives of testosterone.

Mechanism of action

Oxandrolones interact with androgen receptors in target tissues.

TargetActionsOrganism
AAndrogen receptor
agonist
Human
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism

Renal

Route of elimination
Not Available
Half life

0.55 hours (1st phage), 9 hours (2nd phase)

Clearance
Not Available
Toxicity

The oral LD50 of oxandrolone in mice and dogs is greater than 5,000 mg/kg.

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
16-Bromoepiandrosterone16-Bromoepiandrosterone may increase the fluid retaining activities of Oxandrolone.Investigational
19-norandrostenedione19-norandrostenedione may increase the fluid retaining activities of Oxandrolone.Experimental, Illicit
5-androstenedione5-androstenedione may increase the fluid retaining activities of Oxandrolone.Experimental, Illicit
AcarboseOxandrolone may increase the hypoglycemic activities of Acarbose.Approved, Investigational
AcenocoumarolOxandrolone may increase the anticoagulant activities of Acenocoumarol.Approved, Investigational
AlbiglutideOxandrolone may increase the hypoglycemic activities of Albiglutide.Approved
AlclometasoneAlclometasone may increase the fluid retaining activities of Oxandrolone.Approved
AldosteroneAldosterone may increase the fluid retaining activities of Oxandrolone.Experimental, Investigational
AlogliptinOxandrolone may increase the hypoglycemic activities of Alogliptin.Approved
AmcinonideAmcinonide may increase the fluid retaining activities of Oxandrolone.Approved
AndrostenedioneAndrostenedione may increase the fluid retaining activities of Oxandrolone.Experimental, Illicit
AnecortaveAnecortave may increase the fluid retaining activities of Oxandrolone.Investigational
anecortave acetateanecortave acetate may increase the fluid retaining activities of Oxandrolone.Investigational
AtamestaneAtamestane may increase the fluid retaining activities of Oxandrolone.Investigational
Beclomethasone dipropionateBeclomethasone dipropionate may increase the fluid retaining activities of Oxandrolone.Approved, Investigational
BetamethasoneBetamethasone may increase the fluid retaining activities of Oxandrolone.Approved, Vet Approved
BromocriptineOxandrolone may increase the hypoglycemic activities of Bromocriptine.Approved, Investigational
BudesonideBudesonide may increase the fluid retaining activities of Oxandrolone.Approved
CanagliflozinOxandrolone may increase the hypoglycemic activities of Canagliflozin.Approved
ChlorpropamideOxandrolone may increase the hypoglycemic activities of Chlorpropamide.Approved, Investigational
CiclesonideCiclesonide may increase the fluid retaining activities of Oxandrolone.Approved, Investigational
ClobetasolClobetasol may increase the fluid retaining activities of Oxandrolone.Approved, Investigational
Clobetasol propionateClobetasol propionate may increase the fluid retaining activities of Oxandrolone.Approved
ClobetasoneClobetasone may increase the fluid retaining activities of Oxandrolone.Approved
ClocortoloneClocortolone may increase the fluid retaining activities of Oxandrolone.Approved
ClorindioneOxandrolone may increase the anticoagulant activities of Clorindione.Experimental
Conestat alfaOxandrolone may increase the thrombogenic activities of Conestat alfa.Approved, Investigational
Cortexolone 17α-propionateCortexolone 17α-propionate may increase the fluid retaining activities of Oxandrolone.Investigational
CorticosteroneCorticosterone may increase the fluid retaining activities of Oxandrolone.Experimental
Cortisone acetateCortisone acetate may increase the fluid retaining activities of Oxandrolone.Approved, Investigational
CyclosporineOxandrolone may increase the hepatotoxic activities of Cyclosporine.Approved, Investigational, Vet Approved
DapagliflozinOxandrolone may increase the hypoglycemic activities of Dapagliflozin.Approved
DeflazacortDeflazacort may increase the fluid retaining activities of Oxandrolone.Approved, Investigational
DesonideDesonide may increase the fluid retaining activities of Oxandrolone.Approved, Investigational
DesoximetasoneDesoximetasone may increase the fluid retaining activities of Oxandrolone.Approved
Desoxycorticosterone acetateDesoxycorticosterone acetate may increase the fluid retaining activities of Oxandrolone.Approved
Desoxycorticosterone PivalateDesoxycorticosterone Pivalate may increase the fluid retaining activities of Oxandrolone.Experimental, Vet Approved
DexamethasoneDexamethasone may increase the fluid retaining activities of Oxandrolone.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateDexamethasone isonicotinate may increase the fluid retaining activities of Oxandrolone.Vet Approved
DicoumarolOxandrolone may increase the anticoagulant activities of Dicoumarol.Approved
DiflorasoneDiflorasone may increase the fluid retaining activities of Oxandrolone.Approved
DifluocortoloneDifluocortolone may increase the fluid retaining activities of Oxandrolone.Approved, Investigational, Withdrawn
DifluprednateDifluprednate may increase the fluid retaining activities of Oxandrolone.Approved
DiphenadioneOxandrolone may increase the anticoagulant activities of Diphenadione.Experimental
DisopyramideOxandrolone may increase the hypoglycemic activities of Disopyramide.Approved
DulaglutideOxandrolone may increase the hypoglycemic activities of Dulaglutide.Approved, Investigational
EmpagliflozinOxandrolone may increase the hypoglycemic activities of Empagliflozin.Approved
EquileninEquilenin may increase the fluid retaining activities of Oxandrolone.Experimental
EquilinEquilin may increase the fluid retaining activities of Oxandrolone.Approved
EstroneEstrone may increase the fluid retaining activities of Oxandrolone.Approved
Estrone sulfateEstrone sulfate may increase the fluid retaining activities of Oxandrolone.Approved
Ethyl biscoumacetateOxandrolone may increase the anticoagulant activities of Ethyl biscoumacetate.Withdrawn
ExenatideOxandrolone may increase the hypoglycemic activities of Exenatide.Approved, Investigational
FluasteroneFluasterone may increase the fluid retaining activities of Oxandrolone.Investigational
FludrocortisoneFludrocortisone may increase the fluid retaining activities of Oxandrolone.Approved, Investigational
FluindioneOxandrolone may increase the anticoagulant activities of Fluindione.Approved, Investigational
FlumethasoneFlumethasone may increase the fluid retaining activities of Oxandrolone.Approved, Vet Approved
FlunisolideFlunisolide may increase the fluid retaining activities of Oxandrolone.Approved, Investigational
Fluocinolone AcetonideFluocinolone Acetonide may increase the fluid retaining activities of Oxandrolone.Approved, Investigational, Vet Approved
FluocinonideFluocinonide may increase the fluid retaining activities of Oxandrolone.Approved, Investigational
FluocortoloneFluocortolone may increase the fluid retaining activities of Oxandrolone.Approved, Withdrawn
FluorometholoneFluorometholone may increase the fluid retaining activities of Oxandrolone.Approved, Investigational
FluprednideneFluprednidene may increase the fluid retaining activities of Oxandrolone.Approved, Withdrawn
FluprednisoloneFluprednisolone may increase the fluid retaining activities of Oxandrolone.Approved
FlurandrenolideFlurandrenolide may increase the fluid retaining activities of Oxandrolone.Approved
Fluticasone furoateFluticasone furoate may increase the fluid retaining activities of Oxandrolone.Approved
Fluticasone propionateFluticasone propionate may increase the fluid retaining activities of Oxandrolone.Approved
FormestaneFormestane may increase the fluid retaining activities of Oxandrolone.Approved, Investigational, Withdrawn
GliclazideOxandrolone may increase the hypoglycemic activities of Gliclazide.Approved
GlimepirideOxandrolone may increase the hypoglycemic activities of Glimepiride.Approved
GlipizideOxandrolone may increase the hypoglycemic activities of Glipizide.Approved, Investigational
GlyburideOxandrolone may increase the hypoglycemic activities of Glyburide.Approved
HalcinonideHalcinonide may increase the fluid retaining activities of Oxandrolone.Approved, Investigational, Withdrawn
HE3286HE3286 may increase the fluid retaining activities of Oxandrolone.Investigational
Human C1-esterase inhibitorOxandrolone may increase the thrombogenic activities of Human C1-esterase inhibitor.Approved
HydrocortisoneHydrocortisone may increase the fluid retaining activities of Oxandrolone.Approved, Vet Approved
Insulin AspartOxandrolone may increase the hypoglycemic activities of Insulin Aspart.Approved
Insulin DetemirOxandrolone may increase the hypoglycemic activities of Insulin Detemir.Approved
Insulin GlargineOxandrolone may increase the hypoglycemic activities of Insulin Glargine.Approved
Insulin GlulisineOxandrolone may increase the hypoglycemic activities of Insulin Glulisine.Approved
Insulin HumanOxandrolone may increase the hypoglycemic activities of Insulin Human.Approved, Investigational
Insulin LisproOxandrolone may increase the hypoglycemic activities of Insulin Lispro.Approved
IstaroximeIstaroxime may increase the fluid retaining activities of Oxandrolone.Investigational
LiraglutideOxandrolone may increase the hypoglycemic activities of Liraglutide.Approved
LoteprednolLoteprednol may increase the fluid retaining activities of Oxandrolone.Approved
ME-609ME-609 may increase the fluid retaining activities of Oxandrolone.Investigational
MecaserminOxandrolone may increase the hypoglycemic activities of Mecasermin.Approved, Investigational
MedrysoneMedrysone may increase the fluid retaining activities of Oxandrolone.Approved
MelengestrolMelengestrol may increase the fluid retaining activities of Oxandrolone.Vet Approved
MetforminOxandrolone may increase the hypoglycemic activities of Metformin.Approved
MethylprednisoloneMethylprednisolone may increase the fluid retaining activities of Oxandrolone.Approved, Vet Approved
MifepristoneOxandrolone may increase the hypoglycemic activities of Mifepristone.Approved, Investigational
MiglitolOxandrolone may increase the hypoglycemic activities of Miglitol.Approved
MometasoneMometasone may increase the fluid retaining activities of Oxandrolone.Approved, Vet Approved
NateglinideOxandrolone may increase the hypoglycemic activities of Nateglinide.Approved, Investigational
NCX 1022NCX 1022 may increase the fluid retaining activities of Oxandrolone.Investigational
Oleoyl-estroneOleoyl-estrone may increase the fluid retaining activities of Oxandrolone.Investigational
ParamethasoneParamethasone may increase the fluid retaining activities of Oxandrolone.Approved
PentamidineOxandrolone may increase the hypoglycemic activities of Pentamidine.Approved, Investigational
PhenindioneOxandrolone may increase the anticoagulant activities of Phenindione.Approved, Investigational
PhenprocoumonOxandrolone may increase the anticoagulant activities of Phenprocoumon.Approved, Investigational
PioglitazoneOxandrolone may increase the hypoglycemic activities of Pioglitazone.Approved, Investigational
PramlintideOxandrolone may increase the hypoglycemic activities of Pramlintide.Approved, Investigational
PrasteronePrasterone may increase the fluid retaining activities of Oxandrolone.Approved, Investigational, Nutraceutical
Prasterone sulfatePrasterone sulfate may increase the fluid retaining activities of Oxandrolone.Investigational
PrednicarbatePrednicarbate may increase the fluid retaining activities of Oxandrolone.Approved, Investigational
PrednisolonePrednisolone may increase the fluid retaining activities of Oxandrolone.Approved, Vet Approved
PrednisonePrednisone may increase the fluid retaining activities of Oxandrolone.Approved, Vet Approved
PregnenolonePregnenolone may increase the fluid retaining activities of Oxandrolone.Approved, Experimental, Investigational
QuinineOxandrolone may increase the hypoglycemic activities of Quinine.Approved
RepaglinideOxandrolone may increase the hypoglycemic activities of Repaglinide.Approved, Investigational
RimexoloneRimexolone may increase the fluid retaining activities of Oxandrolone.Approved
RosiglitazoneOxandrolone may increase the hypoglycemic activities of Rosiglitazone.Approved, Investigational
SaxagliptinOxandrolone may increase the hypoglycemic activities of Saxagliptin.Approved
SitagliptinOxandrolone may increase the hypoglycemic activities of Sitagliptin.Approved, Investigational
SulfadiazineOxandrolone may increase the hypoglycemic activities of Sulfadiazine.Approved, Investigational, Vet Approved
SulfamethoxazoleOxandrolone may increase the hypoglycemic activities of Sulfamethoxazole.Approved
SulfisoxazoleOxandrolone may increase the hypoglycemic activities of Sulfisoxazole.Approved, Vet Approved
SunitinibOxandrolone may increase the hypoglycemic activities of Sunitinib.Approved, Investigational
TioclomarolOxandrolone may increase the anticoagulant activities of Tioclomarol.Experimental
TixocortolTixocortol may increase the fluid retaining activities of Oxandrolone.Approved, Withdrawn
TolazamideOxandrolone may increase the hypoglycemic activities of Tolazamide.Approved, Investigational
TolbutamideOxandrolone may increase the hypoglycemic activities of Tolbutamide.Approved, Investigational
TriamcinoloneTriamcinolone may increase the fluid retaining activities of Oxandrolone.Approved, Vet Approved
UlobetasolUlobetasol may increase the fluid retaining activities of Oxandrolone.Approved
WarfarinOxandrolone may increase the anticoagulant activities of Warfarin.Approved
Food Interactions
Not Available

References

Synthesis Reference

John Cabaj, "Process for the synthesis of oxandrolone." U.S. Patent US20030032817, issued February 13, 2003.

US20030032817
General References
  1. Demling RH, DeSanti L: Oxandrolone induced lean mass gain during recovery from severe burns is maintained after discontinuation of the anabolic steroid. Burns. 2003 Dec;29(8):793-7. [PubMed:14636753]
External Links
Human Metabolome Database
HMDB0014759
KEGG Drug
D00462
KEGG Compound
C07346
PubChem Compound
5878
PubChem Substance
46509027
ChemSpider
5667
ChEBI
7820
ChEMBL
CHEMBL1200436
Therapeutic Targets Database
DAP000905
PharmGKB
PA164749395
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Oxandrolone
ATC Codes
A14AA08 — Oxandrolone
FDA label
Download (40.6 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1Active Not RecruitingTreatmentMalnutrition1
1CompletedNot AvailableTo Determine the Bioequivalence Under Fasting Conditions1
1CompletedTreatmentCongenital Hypoplastic Anemia1
1RecruitingTreatmentBioavailability1
2CompletedTreatmentAnemias / Functional Iron Deficiency / Traumas1
2CompletedTreatmentDwarfism / Turner's Syndrome1
2CompletedTreatmentTurner's Syndrome1
2, 3CompletedTreatmentMinor burns1
2, 3RecruitingTreatmentMinor burns1
3CompletedSupportive CareUnspecified Adult Solid Tumor, Protocol Specific / Weight Changes1
3TerminatedTreatmentPressure Ulcers1
4CompletedTreatmentHIV Wasting Syndrome1
Not AvailableCompletedTreatmentMuscular Dystrophy1
Not AvailableCompletedTreatmentSpinal Cord Injuries (SCI)1

Pharmacoeconomics

Manufacturers
  • Savient pharmaceuticals inc
  • Par pharmaceutical inc
  • Roxane laboratories inc
  • Sandoz inc
  • Upsher smith laboratories inc
Packagers
  • A-S Medication Solutions LLC
  • BTG Pharmaceuticals Corp.
  • DSM Corp.
  • Eon Labs
  • Letco Medical Inc.
  • Murfreesboro Pharmaceutical Nursing Supply
  • Par Pharmaceuticals
  • Pharmaceutics International Inc.
  • Physicians Total Care Inc.
  • Resource Optimization and Innovation LLC
  • Sandoz
  • Savient Pharmaceuticals
  • Upsher Smith Laboratories
  • Watson Pharmaceuticals
Dosage forms
FormRouteStrength
TabletOral10 mg/1
TabletOral2.5 mg/1
Prices
Unit descriptionCostUnit
Oxandrin 10 mg tablet27.02USD tablet
Oxandrolone 10 mg tablet18.31USD tablet
Oxandrolone 100% powder9.54USD g
Oxandrin 2.5 mg tablet8.08USD tablet
Oxandrolone 2.5 mg tablet5.53USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6670351No1992-10-202012-10-20Us
US5872147No1997-12-052017-12-05Us
US6090799No1997-07-182017-07-18Us
US6576659No1997-12-052017-12-05Us
US6828313No1997-12-052017-12-05Us

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)236.5 °CPhysProp
logP4.2Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.014 mg/mLALOGPS
logP3.36ALOGPS
logP2.95ChemAxon
logS-4.3ALOGPS
pKa (Strongest Basic)-0.53ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area46.53 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity84.75 m3·mol-1ChemAxon
Polarizability35.29 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9908
Blood Brain Barrier+0.9537
Caco-2 permeable+0.6616
P-glycoprotein substrateSubstrate0.6489
P-glycoprotein inhibitor INon-inhibitor0.5085
P-glycoprotein inhibitor IINon-inhibitor0.7936
Renal organic cation transporterNon-inhibitor0.7934
CYP450 2C9 substrateNon-substrate0.7807
CYP450 2D6 substrateNon-substrate0.8763
CYP450 3A4 substrateSubstrate0.7065
CYP450 1A2 substrateNon-inhibitor0.832
CYP450 2C9 inhibitorNon-inhibitor0.7894
CYP450 2D6 inhibitorNon-inhibitor0.966
CYP450 2C19 inhibitorNon-inhibitor0.8868
CYP450 3A4 inhibitorNon-inhibitor0.8455
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9822
Ames testNon AMES toxic0.9499
CarcinogenicityNon-carcinogens0.9501
BiodegradationNot ready biodegradable0.9469
Rat acute toxicity1.5177 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9712
hERG inhibition (predictor II)Non-inhibitor0.7133
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as steroid lactones. These are sterol lipids containing a lactone moiety linked to the steroid skeleton.
Kingdom
Organic compounds
Super Class
Lipids and lipid-like molecules
Class
Steroids and steroid derivatives
Sub Class
Steroid lactones
Direct Parent
Steroid lactones
Alternative Parents
17-hydroxysteroids / 3-oxo-5-alpha-steroids / Oxasteroids and derivatives / Naphthopyrans / Naphthalenes / Delta valerolactones / Pyrans / Oxanes / Tertiary alcohols / Cyclic alcohols and derivatives
show 6 more
Substituents
Steroid lactone / 3-oxosteroid / Hydroxysteroid / 3-oxo-5-alpha-steroid / 17-hydroxysteroid / Oxosteroid / 2-oxasteroid / Naphthopyran / Naphthalene / Delta valerolactone
show 18 more
Molecular Framework
Aliphatic heteropolycyclic compounds
External Descriptors
3-oxo steroid, 17beta-hydroxy steroid, anabolic androgenic steroid, oxa-steroid (CHEBI:7820) / Androstane and derivatives (C07346)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Agonist
General Function
Zinc ion binding
Specific Function
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription ...
Gene Name
AR
Uniprot ID
P10275
Uniprot Name
Androgen receptor
Molecular Weight
98987.9 Da
References
  1. Juul A: The effects of oestrogens on linear bone growth. Hum Reprod Update. 2001 May-Jun;7(3):303-13. [PubMed:11392377]
  2. Zhao J, Bauman WA, Huang R, Caplan AJ, Cardozo C: Oxandrolone blocks glucocorticoid signaling in an androgen receptor-dependent manner. Steroids. 2004 May;69(5):357-66. [PubMed:15219414]
  3. Bi LX, Wiren KM, Zhang XW, Oliveira GV, Klein GL, Mainous EG, Herndon DN: The effect of oxandrolone treatment on human osteoblastic cells. J Burns Wounds. 2007 Mar 7;6:e4. [PubMed:17364004]
  4. Cadwallader AB, Rollins DE, Lim CS: Effect of anabolic-androgenic steroids and glucocorticoids on the kinetics of hAR and hGR nucleocytoplasmic translocation. Mol Pharm. 2010 Jun 7;7(3):689-98. doi: 10.1021/mp900259w. [PubMed:20230007]
  5. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]

Drug created on June 13, 2005 07:24 / Updated on March 02, 2018 02:00