You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on DrugBank.
Not Available
Identification
NameMethaqualone
Accession NumberDB04833
TypeSmall Molecule
GroupsIllicit, Withdrawn
DescriptionMethaqualone is a sedative-hypnotic drug that is similar in effect to barbiturates, a general central nervous system depressant. The sedative-hypnotic activity was first noted by Indian researchers in the 1950s and in 1962 methaqualone itself was patented in the US by Wallace and Tiernan. Its use peaked in the early 1970s as a hypnotic, for the treatment of insomnia, and as a sedative and muscle relaxant. It has also been used illegally as a recreational drug, commonly known as Quaaludes, Sopors, Ludes or Mandrax (particularly in the 1970s in North America) depending on the manufacturer. Since at least 2001, it has been widely used in South Africa, where it is commonly referred to as "smarties" or "geluk-tablette" (meaning happy tablets). Clandestinely produced methaqualone is still seized by government agencies and police forces around the world. [Wikipedia]
Structure
Thumb
SynonymsNot Available
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
QuaaludeRorer
Brand mixturesNot Available
SaltsNot Available
Categories
UNII7ZKH8MQW6T
CAS number72-44-6
WeightAverage: 250.2952
Monoisotopic: 250.11061308
Chemical FormulaC16H14N2O
InChI KeyJEYCTXHKTXCGPB-UHFFFAOYSA-N
InChI
InChI=1S/C16H14N2O/c1-11-7-3-6-10-15(11)18-12(2)17-14-9-5-4-8-13(14)16(18)19/h3-10H,1-2H3
IUPAC Name
2-methyl-3-(2-methylphenyl)-3,4-dihydroquinazolin-4-one
SMILES
CC1=CC=CC=C1N1C(C)=NC2=CC=CC=C2C1=O
Pharmacology
IndicationFor the treatment of insomnia, and as a sedative and muscle relaxant.
Structured Indications Not Available
PharmacodynamicsNot Available
Mechanism of action
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicitySymptoms of overdose include delirium, convulsions, muscle spasms or seizure, cardiac arrest, shortness or loss of breath, vomiting or nausea, and coma or death. The LD50 for mice is 1250 mg/kg and for rats is 326 mg/kg (Strasenburg Labs).
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
1,1,1,2 TetrafluoroethaneThe risk or severity of adverse effects can be increased when Methaqualone is combined with 1,1,1,2 Tetrafluoroethane.Investigational
7-NitroindazoleThe risk or severity of adverse effects can be increased when 7-Nitroindazole is combined with Methaqualone.Experimental
AcepromazineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Methaqualone.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Methaqualone.Approved
adipiplonThe risk or severity of adverse effects can be increased when Methaqualone is combined with adipiplon.Investigational
AgomelatineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Agomelatine.Approved, Investigational
AlfaxaloneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Alfaxalone.Vet Approved
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Methaqualone.Approved, Illicit
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Methaqualone.Experimental, Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Methaqualone.Approved, Illicit, Investigational
AmiodaroneThe metabolism of Methaqualone can be decreased when combined with Amiodarone.Approved, Investigational
AmisulprideThe risk or severity of adverse effects can be increased when Methaqualone is combined with Amisulpride.Approved, Investigational
AmitriptylineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Amitriptyline.Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Methaqualone.Approved, Illicit
AmoxapineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Amoxapine.Approved
AmperozideThe risk or severity of adverse effects can be increased when Methaqualone is combined with Amperozide.Experimental
AprepitantThe serum concentration of Methaqualone can be increased when it is combined with Aprepitant.Approved, Investigational
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Methaqualone.Approved, Investigational
ArticaineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Articaine.Approved
AsenapineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Asenapine.Approved
AtazanavirThe metabolism of Methaqualone can be decreased when combined with Atazanavir.Approved, Investigational
AtomoxetineThe metabolism of Methaqualone can be decreased when combined with Atomoxetine.Approved
AzaperoneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Azaperone.Vet Approved
AzelastineMethaqualone may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
AzelastineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Azelastine.Approved
BaclofenThe risk or severity of adverse effects can be increased when Methaqualone is combined with Baclofen.Approved
BarbitalThe risk or severity of adverse effects can be increased when Barbital is combined with Methaqualone.Illicit
BenperidolThe risk or severity of adverse effects can be increased when Methaqualone is combined with Benperidol.Investigational
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Methaqualone.Approved
Benzyl alcoholThe risk or severity of adverse effects can be increased when Methaqualone is combined with Benzyl alcohol.Approved
BexaroteneThe serum concentration of Methaqualone can be decreased when it is combined with Bexarotene.Approved, Investigational
BoceprevirThe metabolism of Methaqualone can be decreased when combined with Boceprevir.Approved
BortezomibThe metabolism of Methaqualone can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Methaqualone can be decreased when it is combined with Bosentan.Approved, Investigational
BrexpiprazoleThe risk or severity of adverse effects can be increased when Methaqualone is combined with Brexpiprazole.Approved
BrimonidineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Brimonidine.Approved
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Methaqualone.Approved
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Methaqualone.Approved, Illicit
BrompheniramineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Brompheniramine.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Methaqualone is combined with Brotizolam.Approved, Withdrawn
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Methaqualone.Approved, Investigational
BuprenorphineMethaqualone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Methaqualone.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Methaqualone.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Butacaine.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Methaqualone is combined with Butalbital.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Methaqualone is combined with Butamben.Approved
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Methaqualone.Approved, Illicit
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Methaqualone.Approved, Illicit, Vet Approved
CarbamazepineThe metabolism of Methaqualone can be increased when combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Carbinoxamine.Approved
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Methaqualone.Illicit, Vet Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Methaqualone is combined with Carisoprodol.Approved
CeritinibThe serum concentration of Methaqualone can be increased when it is combined with Ceritinib.Approved
CetirizineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Cetirizine.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Methaqualone.Approved, Illicit, Vet Approved
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Methaqualone.Approved, Illicit
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Methaqualone.Approved, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Methaqualone.Approved
ChlorphenamineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Chlorphenamine.Approved
ChlorpromazineThe risk or severity of adverse effects can be increased when Chlorpromazine is combined with Methaqualone.Approved, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Methaqualone.Approved, Withdrawn
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Chlorzoxazone.Approved
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Methaqualone.Approved, Vet Approved
CitalopramThe risk or severity of adverse effects can be increased when Methaqualone is combined with Citalopram.Approved
ClarithromycinThe metabolism of Methaqualone can be decreased when combined with Clarithromycin.Approved
ClemastineThe metabolism of Methaqualone can be decreased when combined with Clemastine.Approved
ClidiniumThe risk or severity of adverse effects can be increased when Methaqualone is combined with Clidinium.Approved
ClobazamThe risk or severity of adverse effects can be increased when Methaqualone is combined with Clobazam.Approved, Illicit
clomethiazoleThe risk or severity of adverse effects can be increased when Methaqualone is combined with clomethiazole.Investigational
ClomipramineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Clomipramine.Approved, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when Methaqualone is combined with Clonazepam.Approved, Illicit
ClonidineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Clonidine.Approved
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Methaqualone.Approved, Illicit
ClotrimazoleThe metabolism of Methaqualone can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Methaqualone.Approved
CobicistatThe metabolism of Methaqualone can be decreased when combined with Cobicistat.Approved
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Methaqualone.Approved, Illicit
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Methaqualone.Approved, Illicit
ConivaptanThe serum concentration of Methaqualone can be increased when it is combined with Conivaptan.Approved, Investigational
CrizotinibThe metabolism of Methaqualone can be decreased when combined with Crizotinib.Approved
CyclizineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Cyclizine.Approved
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Methaqualone.Approved
CyclosporineThe metabolism of Methaqualone can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Cyproheptadine.Approved
DabrafenibThe serum concentration of Methaqualone can be decreased when it is combined with Dabrafenib.Approved
DantroleneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Dantrolene.Approved
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Methaqualone.Approved
DapoxetineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Dapoxetine.Investigational
DarunavirThe metabolism of Methaqualone can be decreased when combined with Darunavir.Approved
DasatinibThe serum concentration of Methaqualone can be increased when it is combined with Dasatinib.Approved, Investigational
DeferasiroxThe serum concentration of Methaqualone can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe metabolism of Methaqualone can be decreased when combined with Delavirdine.Approved
deramciclaneThe risk or severity of adverse effects can be increased when Methaqualone is combined with deramciclane.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Methaqualone.Approved
DesipramineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Desipramine.Approved
DesloratadineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Desloratadine.Approved, Investigational
DesvenlafaxineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Desvenlafaxine.Approved
DetomidineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Detomidine.Vet Approved
DexamethasoneThe serum concentration of Methaqualone can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Dexbrompheniramine.Approved
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Methaqualone.Approved, Vet Approved
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Methaqualone.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Methaqualone.Approved, Illicit, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Methaqualone.Approved
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Methaqualone.Approved, Illicit, Vet Approved
DifenoxinThe risk or severity of adverse effects can be increased when Methaqualone is combined with Difenoxin.Approved, Illicit
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Methaqualone.Approved, Illicit
DihydroergotamineThe metabolism of Methaqualone can be decreased when combined with Dihydroergotamine.Approved
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Methaqualone.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Dihydromorphine is combined with Methaqualone.Experimental, Illicit
DiltiazemThe metabolism of Methaqualone can be decreased when combined with Diltiazem.Approved
DimenhydrinateThe risk or severity of adverse effects can be increased when Methaqualone is combined with Dimenhydrinate.Approved
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Methaqualone.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Methaqualone.Approved, Illicit
DoramectinThe risk or severity of adverse effects can be increased when Methaqualone is combined with Doramectin.Vet Approved
DoxepinThe risk or severity of adverse effects can be increased when Methaqualone is combined with Doxepin.Approved
DoxycyclineThe metabolism of Methaqualone can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Methaqualone.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when Methaqualone is combined with DPDPE.Investigational
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Methaqualone.Approved, Illicit
DronedaroneThe metabolism of Methaqualone can be decreased when combined with Dronedarone.Approved
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Methaqualone.Approved, Vet Approved
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Methaqualone.Experimental, Illicit
DuloxetineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Duloxetine.Approved
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Methaqualone.Approved
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Methaqualone.Experimental, Illicit
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when ECGONINE METHYL ESTER is combined with Methaqualone.Experimental
EcopipamThe risk or severity of adverse effects can be increased when Methaqualone is combined with Ecopipam.Investigational
EfavirenzThe serum concentration of Methaqualone can be decreased when it is combined with Efavirenz.Approved, Investigational
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Methaqualone.Approved, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Methaqualone is combined with Entacapone.Approved, Investigational
EnzalutamideThe serum concentration of Methaqualone can be decreased when it is combined with Enzalutamide.Approved
ErythromycinThe metabolism of Methaqualone can be decreased when combined with Erythromycin.Approved, Vet Approved
EscitalopramThe risk or severity of adverse effects can be increased when Methaqualone is combined with Escitalopram.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Methaqualone can be decreased when it is combined with Eslicarbazepine acetate.Approved
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Methaqualone.Approved, Illicit
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Methaqualone.Approved
EthanolMethaqualone may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Methaqualone.Approved, Illicit, Withdrawn
EthosuximideThe risk or severity of adverse effects can be increased when Methaqualone is combined with Ethosuximide.Approved
EthotoinThe risk or severity of adverse effects can be increased when Methaqualone is combined with Ethotoin.Approved
Ethyl carbamateThe risk or severity of adverse effects can be increased when Ethyl carbamate is combined with Methaqualone.Withdrawn
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Methaqualone.Approved, Illicit
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Methaqualone.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Etidocaine.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Etifoxine.Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Methaqualone is combined with Etizolam.Approved
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Methaqualone.Approved
EtoperidoneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Etoperidone.Approved
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Methaqualone.Illicit, Vet Approved
EtravirineThe serum concentration of Methaqualone can be decreased when it is combined with Etravirine.Approved
EzogabineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Ezogabine.Approved
FelbamateThe risk or severity of adverse effects can be increased when Methaqualone is combined with Felbamate.Approved
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Methaqualone.Approved, Illicit, Withdrawn
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Methaqualone.Approved, Illicit, Investigational, Vet Approved
FexofenadineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Fexofenadine.Approved
FlibanserinThe risk or severity of adverse effects can be increased when Methaqualone is combined with Flibanserin.Approved
FluconazoleThe metabolism of Methaqualone can be decreased when combined with Fluconazole.Approved
FludiazepamThe risk or severity of adverse effects can be increased when Fludiazepam is combined with Methaqualone.Approved, Illicit
FlunarizineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Flunarizine.Approved
FlunitrazepamThe risk or severity of adverse effects can be increased when Flunitrazepam is combined with Methaqualone.Approved, Illicit
FluoxetineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Methaqualone.Approved, Withdrawn
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Methaqualone.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Methaqualone.Approved, Illicit
FluspirileneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Fluspirilene.Approved
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Methaqualone is combined with Fluticasone Propionate.Approved
FluvoxamineThe metabolism of Methaqualone can be decreased when combined with Fluvoxamine.Approved, Investigational
FosamprenavirThe metabolism of Methaqualone can be decreased when combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Methaqualone can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe metabolism of Methaqualone can be increased when combined with Fosphenytoin.Approved
FospropofolThe risk or severity of adverse effects can be increased when Methaqualone is combined with Fospropofol.Approved, Illicit
Fusidic AcidThe serum concentration of Methaqualone can be increased when it is combined with Fusidic Acid.Approved
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Methaqualone.Approved, Investigational
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Methaqualone is combined with gabapentin enacarbil.Approved
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Methaqualone.Approved, Illicit
GepironeThe risk or severity of adverse effects can be increased when Methaqualone is combined with Gepirone.Investigational
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Methaqualone.Approved, Illicit
GuanfacineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Guanfacine.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Methaqualone.Approved, Illicit, Withdrawn
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with Methaqualone.Approved
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Methaqualone.Approved, Vet Approved
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Methaqualone.Approved, Illicit
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Methaqualone.Approved
HydrocodoneMethaqualone may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Methaqualone.Approved, Illicit
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Methaqualone.Approved
IdelalisibThe serum concentration of Methaqualone can be increased when it is combined with Idelalisib.Approved
IloperidoneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Iloperidone.Approved
ImatinibThe metabolism of Methaqualone can be decreased when combined with Imatinib.Approved
ImipramineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Imipramine.Approved
IndalpineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Indalpine.Investigational, Withdrawn
IndinavirThe metabolism of Methaqualone can be decreased when combined with Indinavir.Approved
IsavuconazoniumThe metabolism of Methaqualone can be decreased when combined with Isavuconazonium.Approved, Investigational
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Methaqualone.Approved, Vet Approved
IsradipineThe metabolism of Methaqualone can be decreased when combined with Isradipine.Approved
ItraconazoleThe metabolism of Methaqualone can be decreased when combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Methaqualone can be increased when it is combined with Ivacaftor.Approved
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Methaqualone.Approved, Vet Approved
KetazolamThe risk or severity of adverse effects can be increased when Ketazolam is combined with Methaqualone.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Ketobemidone.Approved
KetoconazoleThe metabolism of Methaqualone can be decreased when combined with Ketoconazole.Approved, Investigational
LamotrigineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Lamotrigine.Approved, Investigational
LevetiracetamThe risk or severity of adverse effects can be increased when Methaqualone is combined with Levetiracetam.Approved, Investigational
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Methaqualone.Approved
LevocabastineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Levocabastine.Approved
LevocetirizineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Levocetirizine.Approved
LevodopaThe risk or severity of adverse effects can be increased when Methaqualone is combined with Levodopa.Approved
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Methaqualone.Approved
LevomilnacipranThe risk or severity of adverse effects can be increased when Methaqualone is combined with Levomilnacipran.Approved
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Methaqualone.Approved
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Methaqualone.Approved, Vet Approved
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with Methaqualone.Approved
LofentanilThe risk or severity of adverse effects can be increased when Methaqualone is combined with Lofentanil.Illicit
LopinavirThe metabolism of Methaqualone can be decreased when combined with Lopinavir.Approved
LoratadineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Loratadine.Approved
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Methaqualone.Approved
LovastatinThe metabolism of Methaqualone can be decreased when combined with Lovastatin.Approved, Investigational
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Methaqualone.Approved
Lu AA21004The risk or severity of adverse effects can be increased when Methaqualone is combined with Lu AA21004.Investigational
LuliconazoleThe serum concentration of Methaqualone can be increased when it is combined with Luliconazole.Approved
LumacaftorThe metabolism of Methaqualone can be increased when combined with Lumacaftor.Approved
LurasidoneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Lurasidone.Approved
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Methaqualone.Approved, Vet Approved
MaprotilineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Maprotiline.Approved
MeclizineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Meclizine.Approved
MedetomidineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Medetomidine.Vet Approved
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Methaqualone.Approved, Nutraceutical, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Melperone.Approved
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Methaqualone.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Methaqualone.Approved, Illicit
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Methaqualone.Approved
MetaxaloneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Metaxalone.Approved
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Methaqualone.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Methaqualone.Approved, Illicit
MethapyrileneThe risk or severity of adverse effects can be increased when Methapyrilene is combined with Methaqualone.Withdrawn
MethocarbamolThe risk or severity of adverse effects can be increased when Methaqualone is combined with Methocarbamol.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Methaqualone.Approved
MethotrimeprazineMethaqualone may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Methaqualone.Approved, Vet Approved
MethsuximideThe risk or severity of adverse effects can be increased when Methaqualone is combined with Methsuximide.Approved
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Methaqualone.Approved
MetyrosineMethaqualone may increase the sedative activities of Metyrosine.Approved
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Methaqualone.Approved, Illicit
MifepristoneThe serum concentration of Methaqualone can be increased when it is combined with Mifepristone.Approved, Investigational
MilnacipranThe risk or severity of adverse effects can be increased when Methaqualone is combined with Milnacipran.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Methaqualone.Approved, Investigational
MirtazapineMethaqualone may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MitotaneThe serum concentration of Methaqualone can be decreased when it is combined with Mitotane.Approved
ModafinilThe serum concentration of Methaqualone can be decreased when it is combined with Modafinil.Approved, Investigational
MolindoneThe risk or severity of adverse effects can be increased when Molindone is combined with Methaqualone.Approved
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Methaqualone.Approved, Investigational
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Methaqualone.Approved, Investigational
NafcillinThe serum concentration of Methaqualone can be decreased when it is combined with Nafcillin.Approved
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Methaqualone.Approved
NefazodoneThe metabolism of Methaqualone can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe metabolism of Methaqualone can be decreased when combined with Nelfinavir.Approved
NetupitantThe serum concentration of Methaqualone can be increased when it is combined with Netupitant.Approved
NevirapineThe metabolism of Methaqualone can be increased when combined with Nevirapine.Approved
NilotinibThe metabolism of Methaqualone can be decreased when combined with Nilotinib.Approved, Investigational
NitrazepamThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Methaqualone.Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Methaqualone is combined with Nitrous oxide.Approved, Vet Approved
NormethadoneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Normethadone.Approved, Illicit
NortriptylineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Nortriptyline.Approved
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Methaqualone.Approved, Investigational
OlaparibThe metabolism of Methaqualone can be decreased when combined with Olaparib.Approved
OlopatadineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Olopatadine.Approved
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Methaqualone.Approved
OpiumThe risk or severity of adverse effects can be increased when Methaqualone is combined with Opium.Approved, Illicit
OrphenadrineMethaqualone may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Methaqualone is combined with Osanetant.Investigational
OsimertinibThe serum concentration of Methaqualone can be increased when it is combined with Osimertinib.Approved
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Methaqualone.Approved
OxetacaineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Oxetacaine.Investigational
OxprenololThe risk or severity of adverse effects can be increased when Oxprenolol is combined with Methaqualone.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Methaqualone.Approved
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Methaqualone.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Methaqualone.Approved, Investigational, Vet Approved
PalbociclibThe serum concentration of Methaqualone can be increased when it is combined with Palbociclib.Approved
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Methaqualone.Approved
ParaldehydeMethaqualone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ParoxetineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Paroxetine.Approved, Investigational
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Methaqualone.Approved, Vet Approved
PentobarbitalThe metabolism of Methaqualone can be increased when combined with Pentobarbital.Approved, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Methaqualone.Approved
PerazineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Perazine.Investigational
PerospironeThe risk or severity of adverse effects can be increased when Methaqualone is combined with Perospirone.Approved
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Methaqualone.Approved
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Methaqualone.Approved
PhenobarbitalThe metabolism of Methaqualone can be increased when combined with Phenobarbital.Approved
PhenoxyethanolThe risk or severity of adverse effects can be increased when Methaqualone is combined with Phenoxyethanol.Approved
PhenytoinThe metabolism of Methaqualone can be increased when combined with Phenytoin.Approved, Vet Approved
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Methaqualone.Approved
PipamperoneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Pipamperone.Approved
PipotiazineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Pipotiazine.Approved
PiritramideThe risk or severity of adverse effects can be increased when Methaqualone is combined with Piritramide.Investigational
PizotifenThe risk or severity of adverse effects can be increased when Methaqualone is combined with Pizotifen.Approved
PomalidomideThe risk or severity of adverse effects can be increased when Methaqualone is combined with Pomalidomide.Approved
PosaconazoleThe metabolism of Methaqualone can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PramipexoleMethaqualone may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Pramocaine.Approved
PrazepamThe risk or severity of adverse effects can be increased when Prazepam is combined with Methaqualone.Approved, Illicit
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Methaqualone.Approved, Illicit, Investigational
PregnanoloneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Pregnanolone.Investigational
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Methaqualone.Approved
PrimidoneThe metabolism of Methaqualone can be increased when combined with Primidone.Approved, Vet Approved
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Methaqualone.Approved, Investigational, Vet Approved
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Methaqualone.Approved, Vet Approved
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Methaqualone.Approved, Vet Approved
PromethazineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Promethazine.Approved
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Methaqualone.Approved, Vet Approved
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Methaqualone.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Propoxycaine.Approved
ProtriptylineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Protriptyline.Approved
PSD502The risk or severity of adverse effects can be increased when Methaqualone is combined with PSD502.Investigational
QuazepamThe risk or severity of adverse effects can be increased when Quazepam is combined with Methaqualone.Approved, Illicit
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Methaqualone.Approved
RacloprideThe risk or severity of adverse effects can be increased when Methaqualone is combined with Raclopride.Investigational
RamelteonThe risk or severity of adverse effects can be increased when Methaqualone is combined with Ramelteon.Approved, Investigational
RanolazineThe metabolism of Methaqualone can be decreased when combined with Ranolazine.Approved, Investigational
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Methaqualone.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Methaqualone.Approved, Withdrawn
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Methaqualone.Approved
RifabutinThe metabolism of Methaqualone can be increased when combined with Rifabutin.Approved
RifampicinThe metabolism of Methaqualone can be increased when combined with Rifampicin.Approved
RifapentineThe metabolism of Methaqualone can be increased when combined with Rifapentine.Approved
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Methaqualone.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Methaqualone is combined with Ritanserin.Investigational
RitonavirThe metabolism of Methaqualone can be decreased when combined with Ritonavir.Approved, Investigational
RomifidineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Romifidine.Vet Approved
RopiniroleMethaqualone may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Methaqualone.Approved
RotigotineMethaqualone may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Methaqualone.Approved
S-EthylisothioureaThe risk or severity of adverse effects can be increased when S-Ethylisothiourea is combined with Methaqualone.Experimental
Sage 547The risk or severity of adverse effects can be increased when Methaqualone is combined with Sage 547.Investigational
SaquinavirThe metabolism of Methaqualone can be decreased when combined with Saquinavir.Approved, Investigational
ScopolamineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Scopolamine.Approved
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Methaqualone.Approved, Vet Approved
SertindoleThe risk or severity of adverse effects can be increased when Methaqualone is combined with Sertindole.Approved, Withdrawn
SertralineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Methaqualone.Approved, Vet Approved
SildenafilThe metabolism of Methaqualone can be decreased when combined with Sildenafil.Approved, Investigational
SiltuximabThe serum concentration of Methaqualone can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Methaqualone can be increased when it is combined with Simeprevir.Approved
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Methaqualone.Approved
St. John's WortThe serum concentration of Methaqualone can be decreased when it is combined with St. John's Wort.Nutraceutical
StiripentolThe serum concentration of Methaqualone can be increased when it is combined with Stiripentol.Approved
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Methaqualone.Approved, Investigational
SulfisoxazoleThe metabolism of Methaqualone can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Methaqualone.Approved
SuvorexantMethaqualone may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
TandospironeThe risk or severity of adverse effects can be increased when Methaqualone is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Methaqualone.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Methaqualone is combined with Tasimelteon.Approved
TelaprevirThe metabolism of Methaqualone can be decreased when combined with Telaprevir.Approved
TelithromycinThe metabolism of Methaqualone can be decreased when combined with Telithromycin.Approved
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Methaqualone.Approved
TetrabenazineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Tetrabenazine.Approved
TetracaineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Tetracaine.Approved, Vet Approved
TetrodotoxinThe risk or severity of adverse effects can be increased when Methaqualone is combined with Tetrodotoxin.Investigational
ThalidomideMethaqualone may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Methaqualone.Approved, Vet Approved
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Methaqualone.Approved, Vet Approved
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Methaqualone.Approved
ThiothixeneThe risk or severity of adverse effects can be increased when Thiothixene is combined with Methaqualone.Approved
TiagabineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Tiagabine.Approved
TiaprideThe risk or severity of adverse effects can be increased when Methaqualone is combined with Tiapride.Investigational
TiclopidineThe metabolism of Methaqualone can be decreased when combined with Ticlopidine.Approved
TiletamineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Tiletamine.Vet Approved
TizanidineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Tizanidine.Approved
TocilizumabThe serum concentration of Methaqualone can be decreased when it is combined with Tocilizumab.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Methaqualone is combined with Tolcapone.Approved, Withdrawn
TopiramateThe risk or severity of adverse effects can be increased when Methaqualone is combined with Topiramate.Approved
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Methaqualone.Approved, Investigational
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Trans-2-Phenylcyclopropylamine is combined with Methaqualone.Experimental
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Methaqualone.Approved
TrazodoneThe risk or severity of adverse effects can be increased when Trazodone is combined with Methaqualone.Approved, Investigational
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Methaqualone.Approved
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Methaqualone.Approved
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Methaqualone.Approved, Vet Approved
TrimipramineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Trimipramine.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Triprolidine.Approved
Uc1010The risk or severity of adverse effects can be increased when Methaqualone is combined with Uc1010.Investigational
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Methaqualone.Approved, Investigational
VenlafaxineThe metabolism of Methaqualone can be decreased when combined with Venlafaxine.Approved
VerapamilThe metabolism of Methaqualone can be decreased when combined with Verapamil.Approved
VigabatrinThe risk or severity of adverse effects can be increased when Methaqualone is combined with Vigabatrin.Approved
VoriconazoleThe metabolism of Methaqualone can be decreased when combined with Voriconazole.Approved, Investigational
VortioxetineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Vortioxetine.Approved
XylazineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Xylazine.Vet Approved
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Methaqualone.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Methaqualone is combined with Ziconotide.Approved
ZimelidineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Zimelidine.Withdrawn
ZiprasidoneThe metabolism of Methaqualone can be decreased when combined with Ziprasidone.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Methaqualone is combined with Zolazepam.Vet Approved
ZolpidemMethaqualone may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe risk or severity of adverse effects can be increased when Methaqualone is combined with Zonisamide.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Methaqualone.Approved
ZotepineThe risk or severity of adverse effects can be increased when Methaqualone is combined with Zotepine.Approved
ZuclopenthixolThe risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Methaqualone.Approved, Investigational
Food InteractionsNot Available
References
Synthesis Reference

Potential Analgesics. Part I. Synthesis of substituted 4-quinazolones, I. K. Kacker and S. H. Zaheer, J. Ind. Chem. Soc. 28 (1951), pp. 344–346.

General ReferencesNot Available
External Links
ATC CodesN05CM01N05CX02
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9953
Blood Brain Barrier+0.9921
Caco-2 permeable+0.8171
P-glycoprotein substrateNon-substrate0.7737
P-glycoprotein inhibitor IInhibitor0.6427
P-glycoprotein inhibitor IIInhibitor0.5
Renal organic cation transporterNon-inhibitor0.8537
CYP450 2C9 substrateNon-substrate0.6892
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.6475
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorInhibitor0.5
CYP450 2D6 inhibitorNon-inhibitor0.9593
CYP450 2C19 inhibitorNon-inhibitor0.8585
CYP450 3A4 inhibitorNon-inhibitor0.8509
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.5384
Ames testAMES toxic0.5126
CarcinogenicityNon-carcinogens0.9142
BiodegradationNot ready biodegradable0.9488
Rat acute toxicity2.8349 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9864
hERG inhibition (predictor II)Non-inhibitor0.61
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point120 °CPhysProp
Predicted Properties
PropertyValueSource
Water Solubility0.0407 mg/mLALOGPS
logP2.54ALOGPS
logP3.17ChemAxon
logS-3.8ALOGPS
pKa (Strongest Basic)-1.2ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area32.67 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity77.11 m3·mol-1ChemAxon
Polarizability27.32 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as quinazolines. These are compounds containing a quinazoline moiety, which is made up of two fused six-member aromatic rings, a benzene ring and a pyrimidine ring.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassNaphthyridines
Sub ClassQuinazolines
Direct ParentQuinazolines
Alternative Parents
Substituents
  • Quinazoline
  • Toluene
  • Pyrimidone
  • Benzenoid
  • Pyrimidine
  • Monocyclic benzene moiety
  • Heteroaromatic compound
  • Lactam
  • Azacycle
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External DescriptorsNot Available

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Comments
comments powered by Disqus
Drug created on September 11, 2007 15:07 / Updated on August 17, 2016 12:24