Fibrinolytic Agents

Name
Fibrinolytic Agents
Accession Number
DBCAT000013
Description

Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN.

ATC Classification
Drugs
DrugDrug Description
AlteplaseA recombinant form of human tissue plasminogen activator used in the emergency treatment of myocardial infarction, ischemic stroke, and pulmonary emboli.
ReteplaseA purified form of human tissue plasminogen activator used in the emergency treatment of myocardial infarction, ischemic stroke, and pulmonary emboli.
AnistreplaseA form of recombinant human tissue plasminogen activator used in the emergency treatment of myocardial infarction and pulmonary emboli.
TenecteplaseA modified form of recombinant human tissue plasminogen activator used in the emergency treatment of myocardial infarction and pulmonary emboli.
Drotrecogin alfaA form of recombinant activated human protein C used to reduce mortality in patients with severe sepsis by inhibiting coagulation Factors V and VIII.
DefibrotideA mixture of single-stranded oligonucleotides used in the treatment of severe hepatic veno-occlusive disease with renal or pulmonary dysfunction following hematopoietic stem-cell transplantation.
AncrodAn anticoagulant purified from the venom of the Malayan pit viper that functions by inactivating circulating plasma fibrinogen. Not currently approved for use or marketed in any country.
SulodexideSulodexide has been used clinically for the prophylaxis and treatment of vascular diseases with increased risk of thrombosis, including intermittent claudication, peripheral arterial occlusive disease and post-myocardial infarc-tion. Also investigated...
DanaparoidA heparinoid with anticoagulant and antithrombotic activities used for the treatment of acute episode of Heparin-Induced Thrombocytopenia (HIT), and for prophylaxis in patients with a history of HIT.
DalteparinA low molecular weight heparin used for the prophylaxis of thrombotic events in certain patients and prevent acute cardiac ischemic events in patients with unstable angina and non-Q-wave myocardial infarction.
TinzaparinA low molecular weight heparin used for the treatment of acute symptomatic deep vein thrombosis with or without pulmonary embolism when administered in conjunction with warfarin.
Protein CA medication used to treat protein C deficiency leading to purpura fulminans or coumarin-induced skin necrosis.
BrinaseNot Annotated
SaruplaseNot Annotated
StreptokinaseA purified fibrinolytic bacterial protein used to breakdown thrombosis in myocardial infarction, pulmonary embolism, and venous thromboembolism.
DesmoteplaseInvestigated for use/treatment in cerebral ischemia and strokes.
FibrinolysinFibrinolysin assists with the healing of minor burns, superficial wounds, ulcers, surgical wounds, and superficial hematomas.
AstaxanthinInvestigated for use/treatment in eye disorders/infections, cancer/tumors (unspecified), and asthma.
UrokinaseA low molecular weight form of human urokinase used to treat pulmonary embolism and myocardial infarction as well as to clear IV lines.
AbciximabA monoclonal anti-glycoprotein IIb/IIIa receptor antibody used to prevent thrombosis during percutaneous coronary intervention.
DicoumarolFor decreasing blood clotting. Often used along with heparin for treatment of deep vein thrombosis.
ArgatrobanA synthetic direct thrombin inhibitor used for the prevention and treatment of thrombosis related to heparin use.
IloprostA synthetic prostacyclin analog indicated to treat pulmonary arterial hypertension (PAH).
AmediplaseInvestigated for use/treatment in myocardial infarction and thrombosis.
FondaparinuxAn anticoagulant used to prevent venous thromboembolism, to treat deep vein thrombosis, and to improve survival following myocardial infarction.
EdoxabanA novel oral anticoagulant used for reducing the risk of stroke and systemic embolism (SE) in patients with nonvalvular atrial fibrillation (NVAF).
MonteplaseMonteplase has been used in trials studying the treatment of Pulmonary Embolism.
Ferric chlorideNot Annotated
Drugs & Drug Targets
DrugTargetType
AlteplaseUrokinase plasminogen activator surface receptortarget
AlteplaseFibrinogen alpha chaintarget
AlteplasePlasminogentarget
AlteplasePlasminogen activator inhibitor 1target
ReteplaseFibrinogen alpha chaintarget
ReteplasePlasminogentarget
ReteplasePlasminogen activator inhibitor 1target
AnistreplaseFibrinogen alpha chaintarget
AnistreplasePlasminogentarget
AnistreplasePlasminogen activator inhibitor 1target
TenecteplaseUrokinase plasminogen activator surface receptortarget
TenecteplasePlasminogen activator inhibitor 1target
TenecteplaseFibrinogen alpha chaintarget
TenecteplasePlasminogen activator inhibitor 2target
TenecteplaseTetranectintarget
TenecteplaseKeratin, type II cytoskeletal 8target
TenecteplaseAnnexin A2target
TenecteplaseCalreticulintarget
TenecteplaseCalnexintarget
TenecteplaseProlow-density lipoprotein receptor-related protein 1target
TenecteplasePlasminogentarget
Drotrecogin alfaCoagulation factor VIIItarget
Drotrecogin alfaCoagulation factor Vtarget
Drotrecogin alfaPlasminogen activator inhibitor 1target
Drotrecogin alfaThrombomodulintarget
Drotrecogin alfaVitamin K-dependent protein Starget
Drotrecogin alfaProthrombintarget
Drotrecogin alfaPlatelet factor 4target
Drotrecogin alfaPlasma serine protease inhibitortarget
Drotrecogin alfaSerpin B6target
Drotrecogin alfaEndothelial protein C receptortarget
DefibrotideAdenosine receptor A1target
DefibrotideAdenosine receptor A2atarget
DefibrotideAdenosine receptor A2btarget
AncrodFibrinogen alpha chaintarget
SulodexideHeparin cofactor 2target
SulodexideAntithrombin-IIItarget
DanaparoidAntithrombin-IIItarget
DalteparinVascular endothelial growth factor Atarget
DalteparinTissue factor pathway inhibitortarget
DalteparinHeparanaseenzyme
DalteparinAntithrombin-IIItarget
DalteparinP-selectintarget
TinzaparinAntithrombin-IIItarget
TinzaparinA disintegrin and metalloproteinase with thrombospondin motifs 4enzyme
TinzaparinIntegrin alpha-4target
TinzaparinStromal cell-derived factor 1target
Protein CCoagulation factor Vtarget
Protein CCoagulation factor VIIItarget
StreptokinasePlasminogentarget
StreptokinaseProteinase-activated receptor 1target
StreptokinaseCytosolic phospholipase A2enzyme
DesmoteplasePlasminogentarget
FibrinolysinPlasminogen activator inhibitor 1target
FibrinolysinUrokinase-type plasminogen activatortarget
AstaxanthinNF-kappa-B inhibitor alphatarget
UrokinaseUrokinase plasminogen activator surface receptortarget
UrokinasePlasminogentarget
UrokinasePlasminogen activator inhibitor 2target
UrokinasePlasminogen activator inhibitor 1target
UrokinasePlasma serine protease inhibitortarget
UrokinaseNidogen-1target
UrokinaseLow-density lipoprotein receptor-related protein 2target
UrokinaseSuppressor of tumorigenicity 14 proteintarget
UrokinaseMacrophage metalloelastaseenzyme
AbciximabIntegrin beta-3target
AbciximabLow affinity immunoglobulin gamma Fc region receptor II-atarget
AbciximabLow affinity immunoglobulin gamma Fc region receptor II-btarget
AbciximabIntegrin alpha-IIbtarget
AbciximabVitronectintarget
DicoumarolVitamin K epoxide reductase complex subunit 1target
DicoumarolNAD(P)H dehydrogenase [quinone] 1target
DicoumarolQuinone oxidoreductasetarget
DicoumarolCytochrome P450 2C9enzyme
DicoumarolSerum albumincarrier
DicoumarolCytochrome P450 2C6enzyme
DicoumarolCytochrome P450 2C11enzyme
ArgatrobanProthrombintarget
ArgatrobanCytochrome P450 3A4enzyme
ArgatrobanCytochrome P450 3A5enzyme
ArgatrobanSerum albumincarrier
Argatrobanalpha1-acid glycoproteincarrier
IloprostProstacyclin receptortarget
IloprostTissue-type plasminogen activatortarget
IloprostcAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
IloprostSolute carrier organic anion transporter family member 2B1transporter
IloprostSolute carrier organic anion transporter family member 2A1transporter
IloprostSolute carrier organic anion transporter family member 3A1transporter
IloprostcAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
IloprostcAMP-specific 3',5'-cyclic phosphodiesterase 4Ctarget
IloprostcAMP-specific 3',5'-cyclic phosphodiesterase 4Dtarget
IloprostProstaglandin E2 receptor EP1 subtypetarget
IloprostProstaglandin D2 receptor 2target
FondaparinuxAntithrombin-IIItarget
FondaparinuxCoagulation factor Xtarget
EdoxabanCoagulation factor Xtarget
EdoxabanP-glycoprotein 1transporter