Identification

Logo pink
Are you a
new drug developer?
Contact us to learn more about our customized products and solutions.
Name
Regramostim
Accession Number
DB05386
Type
Biotech
Groups
Investigational
Biologic Classification
Protein Based Therapies
Other protein based therapies
Description

Regramostim (GM-CSF) is a differentially glycosylated factor produced mainly by activated T cells and macrophages. Endothelial cells and fibroblasts can also produce GM-CSF after exposure to TNF-α, IL-1, IL-2 and IFN-γ. GM-CSF is found associated with extracellular matrix and in membrane-bound formats too. GM-CSF stimulates proliferation, activation and differentiation of macrophages and granulocytes and their progenitors.

Protein chemical formula
Not Available
Protein average weight
Not Available
Sequences
Not Available
Synonyms
  • Colony-stimulating factor 2 (human clone pCSF-1 protein moiety reduced), glycoform GMC 89-107
  • GM-CSF
  • Regramostim
  • Regramostime
  • Regramostimum
  • rhGm-CSF
External IDs
GMC 89-107
Categories
UNII
KR89Q40F01
CAS number
127757-91-9

Pharmacology

Indication

Investigated for use/treatment in adverse effects (chemotherapy) and bone marrow transplant.

Pharmacodynamics
Not Available
Mechanism of action

This drug activates mononuclear phagocytes, promotes migration of epithelial cells, and further regulates cytokine production. In 2 recent placebo-controlled studies involving venous leg ulceration, subcutaneous perilesional injections of recombinant human granulocyte-macrophage colony-stimulating factor were found to be significantly better than placebo in the time to complete wound healing. In other studies, recombinant human granulocyte-macrophage colony-stimulating factor was administered topically to wounds. Several case reports have also demonstrated the use of recombinant human granulocyte-macrophage colony-stimulating factor for postsurgical wounds, chronic leg ulcers of sickle cell anemia patients, and refract and refractory pyoderma gangrenosum.

TargetActionsOrganism
UGranulocyte-macrophage colony-stimulating factor receptor subunit alphaNot AvailableHumans
UGM-CSF receptor alpha subunitNot AvailableHumans
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
AclidiniumThe therapeutic efficacy of Aclidinium can be decreased when used in combination with recombinant human GM-CSF.
AgmatineThe therapeutic efficacy of Agmatine can be decreased when used in combination with recombinant human GM-CSF.
AlcuroniumThe therapeutic efficacy of Alcuronium can be decreased when used in combination with recombinant human GM-CSF.
AmitriptylineThe therapeutic efficacy of Amitriptyline can be decreased when used in combination with recombinant human GM-CSF.
AmobarbitalThe therapeutic efficacy of Amobarbital can be decreased when used in combination with recombinant human GM-CSF.
AmoxapineThe therapeutic efficacy of Amoxapine can be decreased when used in combination with recombinant human GM-CSF.
Anisotropine methylbromideThe therapeutic efficacy of Anisotropine methylbromide can be decreased when used in combination with recombinant human GM-CSF.
AprobarbitalThe therapeutic efficacy of Aprobarbital can be decreased when used in combination with recombinant human GM-CSF.
AripiprazoleThe therapeutic efficacy of Aripiprazole can be decreased when used in combination with recombinant human GM-CSF.
AtracuriumThe therapeutic efficacy of Atracurium can be decreased when used in combination with recombinant human GM-CSF.
Additional Data Available
  • Extended Description
    Extended Description

    Extended description of the mechanism of action and particular properties of each drug interaction.

    Learn more
  • Severity
    Severity

    A severity rating for each drug interaction, from minor to major.

    Learn more
  • Evidence Level
    Evidence Level

    A rating for the strength of the evidence supporting each drug interaction.

    Learn more
  • Action
    Action

    An effect category for each drug interaction. Know how this interaction affects the subject drug.

    Learn more
Food Interactions
Not Available

References

General References
  1. Sardana R, Dudani AK, Tackaberry E, Alli Z, Porter S, Rowlandson K, Ganz P, Altosaar I: Biologically active human GM-CSF produced in the seeds of transgenic rice plants. Transgenic Res. 2007 Dec;16(6):713-21. Epub 2007 Feb 16. [PubMed:17985214]
  2. Rosas M, Gordon S, Taylor PR: Characterisation of the expression and function of the GM-CSF receptor alpha-chain in mice. Eur J Immunol. 2007 Sep;37(9):2518-28. [PubMed:17694571]
External Links
PubChem Substance
347910111

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1Active Not RecruitingTreatmentProstate Cancer1
1RecruitingBasic ScienceAutoimmune Pulmonary Alveolar Proteinosis1
1, 2CompletedTreatmentProstatic Neoplasms1
2CompletedTreatmentAppendicitis perforated1
2RecruitingTreatmentAcute Respiratory Distress Syndrome (ARDS)1
2RecruitingTreatmentCystic Fibrosis (CF) / Mycobacterium Infections, Nontuberculous1
2RecruitingTreatmentLung Cancer Metastatic1
2RecruitingTreatmentMalignant Neoplasm of Colon1
2Unknown StatusTreatmentMalignant Neoplasm of Nasopharynx1
2WithdrawnTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)1
3Enrolling by InvitationTreatmentAutoimmune Pulmonary Alveolar Proteinosis1
4CompletedTreatmentDeep Partial Thickness Burn1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available

Taxonomy

Description
Not Available
Kingdom
Organic Compounds
Super Class
Organic Acids
Class
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Peptides
Alternative Parents
Not Available
Substituents
Not Available
Molecular Framework
Not Available
External Descriptors
Not Available

Targets

Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Receptor activity
Specific Function
Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.
Gene Name
CSF2RA
Uniprot ID
P15509
Uniprot Name
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
Molecular Weight
46206.185 Da
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Not Available
Specific Function
Not Available
Gene Name
CSF2RA
Uniprot ID
Q16498
Uniprot Name
GM-CSF receptor alpha subunit
Molecular Weight
3014.39 Da

Enzymes

Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Identical protein binding
Specific Function
Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.
Gene Name
BCHE
Uniprot ID
P06276
Uniprot Name
Cholinesterase
Molecular Weight
68417.575 Da
References
  1. Takahashi M, Nikkuni K, Moriyama Y, Shibata A: GM-CSF-mediated impairment of liver to synthesize albumin, cholinesterase, and cholesterol. Am J Hematol. 1991 Mar;36(3):213-4. [PubMed:1996559]

Drug created on November 18, 2007 11:24 / Updated on June 04, 2019 06:16