Cholinesterase Inhibitors

Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system.
DrugDrug NameDrug Description
DB00382TacrineFor the palliative treatment of mild to moderate dementia of the Alzheimer's type.
DB00545PyridostigmineA cholinesterase inhibitor used to treat myasthenia gravis.
DB00674GalantamineA benzazepine derivative used to treat mild to moderate dementia associated with Alzheimer's Disease.
DB00677IsoflurophateFor use in the eye to treat certain types of glaucoma and other eye conditions, such as accommodative esotropia.
DB00843DonepezilAn acetylcholinesterase inhibitor used to treat the behavioral and cognitive effects of Alzheimer's Disease and other types of dementia.
DB00944DemecariumFor the topical treatment of chronic open-angle glaucoma.
DB00981PhysostigmineA cholinesterase inhibitor used to treat glaucoma and anticholinergic toxicity.
DB00989RivastigmineA cholinesterase inhibitor used to treat mild to moderate dementia in Alzheimer's and Parkinson's.
DB01010EdrophoniumA cholinesterase inhibitor used to diagnose and evaluate myasthenia gravis.
DB01122AmbenoniumA cholinesterase inhibitor that targets both muscarinic and nicotinic receptors indicated for the treatment of myasthenia gravis.
DB01400NeostigmineA cholinesterase inhibitor used in the symptomatic treatment of myasthenia gravis by improving muscle tone.
DB13694DistigmineDistigmine is a parasympathomimetic agent with a longer duration of action and enhanced drug accumulation compared to DB00545 and DB01400. It is an anticholinergic drug and long-acting reversible carbamate cholinesterase...
DB00772MalathionA parasympathomimetic organophosphate used to treat head lice.
DB01057EchothiophateAn acetylcholinesterase inhibitor used in ophthalmic preparations to increase the drainage of intraocular fluid; most commonly used for the treatment of glaucoma.
DB023651,10-PhenanthrolineNot Available
DB04864Huperzine AInvestigated for use/treatment in alzheimer's disease.
DB11390CoumaphosThis drug is a fat-soluble phosphorothioate agent that kills both insects and mites. It is non-volatile in nature and is well known by a variety of names as such a...
DB11397DichlorvosDichlorvos or 2,2-dichlorovinyl dimethyl phosphate is a drug of the organophosphate class, frequently used as an insecticide for the control of indoor pests and for the protection of stored products...
DB11412FenthionFenthion is an organothiophosphate drug used as an insecticide, avicide, and acaricide. Its mode of action is explained by cholinesterase enzyme inhibition, which is similar to other organophosphates. Fenthion is...
DB11473MetrifonateMetrifonate or trichlorfon is an irreversible organophosphate acetylcholinesterase inhibitor. It is a prodrug which is activated non-enzymatically into 2,2-dichlorovinyl dimethyl phosphate.
DB13058Methanesulfonyl FluorideMethanesulfonyl Fluoride has been used in trials studying the treatment of Safety.
DB13495ParaoxonNot Annotated
DB01381Ginkgo bilobaAppears to be effective in: alleviating age-related memory impairment in some elderly people with mild to moderate age-related memory or cognitive impairment; improving cognitive function in healthy young to middle-aged...
DB13668IpidacrineNot Annotated
DB00483Gallamine triethiodideA nondepolarizing nerve blocker used in addition to anesthesia to cause skeletal muscle relaxation.
DB01199TubocurarineA neuromuscular blocker used for the diagnosis of and facilitation of intubation after induction of anesthesia during surgical procedures.
DB01245DecamethoniumFor use as a skeletal muscle relaxant
DB00805MinaprineFor the treatment of depression
DB00358MefloquineAn antimalarial agent used as a schizonticidal agent.
DB01233MetoclopramideAn antiemetic agent and dopamine D2 antagonist used in the treatment of gastroesophageal reflux disease, prevention of nausea and vomiting, and to stimulate gastric emptying.
DB13503TyrothricinA topical antibiotic with broad spectrum activity against Gram positive bacteria and some fungal infections.
DB06692AprotininA serine protease inhibitor used to reduce the risk for perioperative blood loss and the need for blood transfusion in high-risk patients during cardiopulmonary bypass for coronary artery bypass graft surgery.
DB04572ThiotepaAn alkylating agent used to prevent graft rejection in stem cell transplantation and to treat a variety of malignancies including certain types of adenocarcinoma and superficial bladder carcinomas.
DB00888MechlorethamineAn antineoplastic agent used to treat Hodgkin's disease, lymphosarcoma, and chronic myelocytic or lymphocytic leukemia.
DB14031TretamineToxic alkylating agent used in industry; also as antineoplastic and research tool to produce chromosome aberrations and cancers.
DB00941HexafluroniumUsed as an adjunct with succinylcholine (or suxamethonium chloride) to prolong muscle relaxation and to prevent succinylcholine-induced muscle fasciculations.
DB00392ProfenamineAn antidyskinetic phenothiazine used to treat the symptoms of Parkinson's disease.
DB00477ChlorpromazineA phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children.
DB00527CinchocaineAn anesthetic used for local or regional anesthesia.
DB00871TerbutalineA beta-2 adrenergic agonist used as a bronchodilator and to prevent premature labor.
DB01035ProcainamideA medication used to treat life threatening ventricular arrhythmias.
DB01337PancuroniumA neuromuscular blocker used as an adjunct to general anesthesia to facilitate tracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
DB01408BambuterolFor the prevention and reversal of bronchospasm in patients 12 years of age and older with asthma and reversible bronchospasm associated with bronchitis and emphysema.
DB04892PhenserineFor the treatment of Alzheimer's disease (AD).
DB06756Glycine betaineA methyl group donor used for the treatment of homocystinuria to decrease elevated homocysteine blood levels.
DB06774CapsaicinA topical analgesic agent used for the symptomatic relief of neuropathic pain associated with post-herpetic neuralgia, as well as other muscle and joint pain.
DB00711DiethylcarbamazineAn anthelmintic used to treat filarial infections like Wuchereria bancrofti and Loa loa.
DB00585NizatidineAn H2 receptor antagonist used to treat GERD and a variety of ulcers.
DB00082PegvisomantA growth hormone receptor antagonist used to treat acromegaly.
DB00790PerindoprilAn ACE inhibitor prodrug used to treat hypertension, mild to moderate congestive heart failure, and to reduce cardiovascular risk in patients with hypertension or post-myocardial infarction.
DB01338PipecuroniumA nondepolarizing neuromuscular blocking agent used to relax muscles during anesthesia and surgical procedures.
DB00515CisplatinA platinum based chemotherapy agent used to treat various sarcomas, carcinomas, lymphomas, and germ cell tumors.
DB00721ProcaineA local anesthetic used for anesthesia, peripheral nerve block, and spinal nerve block.
DB00178RamiprilAn ACE inhibitor used for the management of hypertension and the reduction of cardiovascular mortality following myocardial infarction in hemodynamically stable patients with clinical signs of congestive heart failure.
DB05386RegramostimInvestigated for use/treatment in adverse effects (chemotherapy) and bone marrow transplant.
DB00391SulpirideSulpiride is indicated for the treatment of schizophrenia.
DB00508TriflupromazineUsed mainly in the management of psychoses. Also used to control nausea and vomiting.
DB01221KetamineA rapid-acting general anesthetic and NMDA receptor antagonist used for induction of anesthesia diagnostic and surgical procedures typically in combination with a muscle relaxant.
DB01043MemantineAn NMDA receptor antagonist used to treat moderate to severe dementia in Alzheimer's.
DB00863RanitidineA histamine H2 antagonist used to treat duodenal ulcers, Zollinger-Ellison syndrome, gastric ulcers, GERD, and erosive esophagitis.
DB12482AcotiamideAcotiamide has been used in trials studying the treatment of Dyspepsia and Functional Dyspepsia.
DB15317PosiphenPosiphen is under investigation in clinical trial NCT02925650 (Safety, Tolerability, PK and PD of Posiphen® in Subjects With Early Alzheimer's Disease).
DB02845Methylphosphinic AcidNot Available
DrugDrug NameTargetType
DB00382TacrineAcetylcholinesterasetarget
DB00382TacrineCytochrome P450 1A2enzyme
DB00382TacrineCholinesterasetarget
DB00382TacrineP-glycoprotein 1transporter
DB00382TacrineLiver carboxylesterase 1target
DB00545PyridostigmineAcetylcholinesterasetarget
DB00545PyridostigmineCholinesterasetarget
DB00545PyridostigmineSerum albumintarget
DB00674GalantamineAcetylcholinesterasetarget
DB00674GalantamineCytochrome P450 3A4enzyme
DB00674GalantamineCytochrome P450 2D6enzyme
DB00674GalantamineAcetylcholine receptor subunit alphatarget
DB00674GalantamineAcetylcholine receptor subunit betatarget
DB00674GalantamineAcetylcholine receptor subunit deltatarget
DB00674GalantamineAcetylcholine receptor subunit gammatarget
DB00674GalantamineAcetylcholine receptor subunit epsilontarget
DB00674GalantamineNeuronal acetylcholine receptor subunit alpha-2target
DB00674GalantamineNeuronal acetylcholine receptor subunit alpha-3target
DB00674GalantamineNeuronal acetylcholine receptor subunit alpha-4target
DB00674GalantamineNeuronal acetylcholine receptor subunit alpha-5target
DB00674GalantamineNeuronal acetylcholine receptor subunit alpha-6target
DB00674GalantamineNeuronal acetylcholine receptor subunit alpha-7target
DB00674GalantamineNeuronal acetylcholine receptor subunit alpha-9target
DB00674GalantamineNeuronal acetylcholine receptor subunit alpha-10target
DB00674GalantamineNeuronal acetylcholine receptor subunit beta-2target
DB00674GalantamineNeuronal acetylcholine receptor subunit beta-3target
DB00674GalantamineNeuronal acetylcholine receptor subunit beta-4target
DB00674GalantamineCholinesterasetarget
DB00677IsoflurophateCholinesterasetarget
DB00677IsoflurophateAcetylcholinesterasetarget
DB00677IsoflurophateCholinesteraseenzyme
DB00677IsoflurophateSerum albumincarrier
DB00677IsoflurophateSerotransferrintarget
DB00843DonepezilAcetylcholinesterasetarget
DB00843Donepezil5-hydroxytryptamine receptor 2Atarget
DB00843DonepezilCytochrome P450 3A4enzyme
DB00843DonepezilCytochrome P450 2D6enzyme
DB00843DonepezilCytochrome P450 2C9enzyme
DB00843DonepezilCholinesterasetarget
DB00843DonepezilNitric oxide synthase, braintarget
DB00843DonepezilTumor necrosis factor-inducible gene 6 proteintarget
DB00843DonepezilInterleukin-1 betatarget
DB00843DonepezilNuclear factor NF-kappa-Btarget
DB00843DonepezilATP-binding cassette sub-family G member 2transporter
DB00843DonepezilP-glycoprotein 1transporter
DB00843DonepezilNMDA receptortarget
DB00944DemecariumAcetylcholinesterasetarget
DB00944DemecariumCholinesterasetarget
DB00981PhysostigmineAcetylcholinesterasetarget
DB00981PhysostigmineNeuronal acetylcholine receptor subunit alpha-4target
DB00981PhysostigmineNeuronal acetylcholine receptor subunit beta-2target
DB00989RivastigmineAcetylcholinesterasetarget
DB00989RivastigmineCholinesterasetarget
DB01010EdrophoniumAcetylcholinesterasetarget
DB01010EdrophoniumCholinesterasetarget
DB01122AmbenoniumAcetylcholinesterasetarget
DB01122AmbenoniumCholinesteraseenzyme
DB01400NeostigmineAcetylcholinesterasetarget
DB01400NeostigmineCholinesteraseenzyme
DB00772MalathionCholinesterasetarget
DB00772MalathionCytochrome P450 1A2enzyme
DB00772MalathionCytochrome P450 2B6enzyme
DB01057EchothiophateCholinesterasetarget
DB01057EchothiophateSerum albumincarrier
DB023651,10-PhenanthrolineMethyl-accepting chemotaxis protein IItarget
DB023651,10-PhenanthrolineMetallo-beta-lactamase L1target
DB04864Huperzine AAcetylcholinesterasetarget
DB11397DichlorvosSerum albumincarrier
DB11397DichlorvosSerotransferrintarget
DB11397DichlorvosCholinesterasetarget
DB01381Ginkgo bilobaCytochrome P450 2C9enzyme
DB01381Ginkgo bilobaPhospholipase A2, membrane associatedtarget
DB01381Ginkgo bilobaSodium-dependent noradrenaline transportertarget
DB01381Ginkgo bilobaGlycine receptor subunit alpha-1target
DB01381Ginkgo bilobaGamma-aminobutyric acid receptor subunit alpha-1target
DB01381Ginkgo bilobaGamma-aminobutyric acid receptor subunit beta-2target
DB01381Ginkgo bilobaGamma-aminobutyric acid receptor subunit gamma-2target
DB00483Gallamine triethiodideNeuronal acetylcholine receptor subunit alpha-2target
DB00483Gallamine triethiodideMuscarinic acetylcholine receptor M2target
DB00483Gallamine triethiodideAcetylcholinesterasetarget
DB00483Gallamine triethiodideMuscarinic acetylcholine receptor M1target
DB00483Gallamine triethiodideMuscarinic acetylcholine receptor M5target
DB01199TubocurarineNeuronal acetylcholine receptor subunit alpha-2target
DB01199TubocurarineAcetylcholinesterasetarget
DB01199Tubocurarine5-hydroxytryptamine receptor 3Atarget
DB01199TubocurarineSolute carrier family 22 member 1transporter
DB01199TubocurarineSolute carrier family 22 member 2transporter
DB01199TubocurarineNeuronal acetylcholine receptor subunit alpha-7target
DB01199TubocurarineCholinesteraseenzyme
DB01245DecamethoniumNeuronal acetylcholine receptor subunit alpha-2target
DB01245DecamethoniumAcetylcholinesterasetarget
DB01245DecamethoniumCholinesteraseenzyme
DB01245DecamethoniumNeuronal acetylcholine receptor subunit alpha-4target
DB01245DecamethoniumNeuronal acetylcholine receptor subunit beta-2target
DB00805MinaprineDopamine D1 receptortarget
DB00805MinaprineDopamine D2 receptortarget
DB00805Minaprine5-hydroxytryptamine receptor 2Atarget
DB00805Minaprine5-hydroxytryptamine receptor 2Btarget
DB00805Minaprine5-hydroxytryptamine receptor 2Ctarget
DB00805MinaprineSodium-dependent serotonin transportertarget
DB00805MinaprineCytochrome P450 2D6enzyme
DB00805MinaprineMuscarinic acetylcholine receptor M1target
DB00805MinaprineAcetylcholinesterasetarget
DB00805MinaprineAmine oxidase [flavin-containing] Atarget
DB00358MefloquineHemoglobin subunit alphatarget
DB00358MefloquineCholinesteraseenzyme
DB00358MefloquineCytochrome P450 3A4enzyme
DB00358MefloquineAdenosine receptor A2atarget
DB00358MefloquineFe(II)-protoporphyrin IXtarget
DB00358MefloquineP-glycoprotein 1transporter
DB00358MefloquineCytochrome P450 19A1enzyme
DB00358MefloquineAcetylcholinesteraseenzyme
DB01233MetoclopramideMuscarinic acetylcholine receptor M1target
DB01233MetoclopramideDopamine D2 receptortarget
DB01233MetoclopramideCytochrome P450 2D6enzyme
DB01233Metoclopramide5-hydroxytryptamine receptor 4target
DB01233Metoclopramide5-hydroxytryptamine receptor 3Atarget
DB01233MetoclopramideCytochrome P450 3A4enzyme
DB01233MetoclopramideCytochrome P450 1A2enzyme
DB01233MetoclopramideP-glycoprotein 1transporter
DB01233MetoclopramideAlpha-1-acid glycoprotein 1carrier
DB13503TyrothricinAcetylcholinesterasetarget
DB13503TyrothricinBeta-galactosidasetarget
DB13503TyrothricinPhospholipid membranetarget
DB06692AprotininTrypsin-1target
DB06692AprotininChymotrypsinogen Btarget
DB06692AprotininPlasminogentarget
DB06692AprotininKallikrein-1target
DB06692AprotininCholinesteraseenzyme
DB04572ThiotepaCytochrome P450 2B6enzyme
DB04572ThiotepaCytochrome P450 3A4enzyme
DB04572ThiotepaDNAtarget
DB04572ThiotepaCholinesteraseenzyme
DB00888MechlorethamineDNAtarget
DB00888MechlorethamineCholinesteraseenzyme
DB14031TretamineCholinesteraseenzyme
DB00941HexafluroniumCholinesterasetarget
DB00392ProfenamineGlutamate receptor ionotropic, NMDA 3Atarget
DB00392ProfenamineMuscarinic acetylcholine receptor M1target
DB00392ProfenamineCholinesteraseenzyme
DB00392ProfenamineMuscarinic acetylcholine receptor M2target
DB00477ChlorpromazineDopamine D2 receptortarget
DB00477Chlorpromazine5-hydroxytryptamine receptor 2Atarget
DB00477ChlorpromazineCytochrome P450 2D6enzyme
DB00477ChlorpromazineCholinesteraseenzyme
DB00477ChlorpromazineCytochrome P450 1A2enzyme
DB00477ChlorpromazineSerum albumincarrier
DB00477ChlorpromazineP-glycoprotein 1transporter
DB00477ChlorpromazineDopamine D1 receptortarget
DB00477Chlorpromazine5-hydroxytryptamine receptor 1Atarget
DB00477ChlorpromazineAlpha-1A adrenergic receptortarget
DB00477ChlorpromazineAlpha-1B adrenergic receptortarget
DB00477ChlorpromazineCytochrome P450 2E1enzyme
DB00477ChlorpromazineCytochrome P450 3A4enzyme
DB00477ChlorpromazineHistamine H1 receptortarget
DB00477ChlorpromazinePotassium voltage-gated channel subfamily H member 2target
DB00477ChlorpromazineD(1) dopamine receptortarget
DB00477ChlorpromazineDopamine D3 receptortarget
DB00477ChlorpromazineDopamine D4 receptortarget
DB00477ChlorpromazineDopamine D5 receptortarget
DB00477Chlorpromazine5-hydroxytryptamine receptor 2Ctarget
DB00477Chlorpromazine5-hydroxytryptamine 2 receptortarget
DB00477ChlorpromazineAlpha-1 adrenergic receptorstarget
DB00477ChlorpromazineAlpha-2 adrenergic receptorstarget
DB00477ChlorpromazineMuscarinic acetylcholine receptor M1target
DB00477ChlorpromazineMuscarinic acetylcholine receptor M3target
DB00477ChlorpromazineSphingomyelin phosphodiesterasetarget
DB00477ChlorpromazineCalmodulintarget
DB00477Chlorpromazinealpha1-acid glycoproteintarget
DB00477Chlorpromazine5-hydroxytryptamine receptor 6target
DB00477Chlorpromazine5-hydroxytryptamine receptor 7target
DB00477ChlorpromazineHistamine H4 receptortarget
DB00477ChlorpromazineBile salt export pumptransporter
DB00527CinchocaineSodium channel protein type 5 subunit alphatarget
DB00527CinchocaineSodium channel protein type 10 subunit alphatarget
DB00527CinchocaineCalmodulintarget
DB00527CinchocaineCholinesteraseenzyme
DB00871TerbutalineBeta-2 adrenergic receptortarget
DB00871TerbutalineCholinesteraseenzyme
DB00871TerbutalineBeta-3 adrenergic receptortarget
DB00871TerbutalineBeta-1 adrenergic receptortarget
DB01035ProcainamideSodium channel protein type 5 subunit alphatarget
DB01035ProcainamideDNA (cytosine-5)-methyltransferase 1target
DB01035ProcainamideCytochrome P450 2D6enzyme
DB01035ProcainamideCholinesteraseenzyme
DB01035ProcainamideSolute carrier family 22 member 2transporter
DB01035ProcainamideSolute carrier family 22 member 1transporter
DB01035ProcainamideSolute carrier family 22 member 3transporter
DB01035ProcainamideSolute carrier family 22 member 5transporter
DB01035ProcainamideSolute carrier family 22 member 4transporter
DB01035ProcainamidePotassium voltage-gated channel subfamily H member 2target
DB01035ProcainamideMultidrug and toxin extrusion protein 1transporter
DB01035ProcainamideMultidrug and toxin extrusion protein 2transporter
DB01337PancuroniumNeuronal acetylcholine receptor subunit alpha-2target
DB01337PancuroniumCholinesteraseenzyme
DB01337PancuroniumMuscarinic acetylcholine receptor M2target
DB01337PancuroniumMuscarinic acetylcholine receptor M3target
DB01337PancuroniumSolute carrier family 22 member 1transporter
DB01337PancuroniumSolute carrier family 22 member 2transporter
DB01408BambuterolBeta-2 adrenergic receptortarget
DB01408BambuterolCholinesteraseenzyme
DB04892PhenserineAcetylcholinesterasetarget
DB04892PhenserineCholinesterasetarget
DB04892PhenserineAmyloid beta A4 proteintarget
DB06756Glycine betaineCholinesteraseenzyme
DB06756Glycine betaineProline dehydrogenase 1, mitochondrialenzyme
DB06756Glycine betaineApoptosis regulator Bcl-2target
DB06774CapsaicinCytochrome P450 3A4enzyme
DB06774CapsaicinProstaglandin G/H synthase 2enzyme
DB06774CapsaicinMyeloperoxidaseenzyme
DB06774CapsaicinCytochrome P450 1A2enzyme
DB06774CapsaicinCytochrome P450 2E1enzyme
DB06774CapsaicinAmine oxidase [flavin-containing] Aenzyme
DB06774CapsaicinDopamine beta-hydroxylaseenzyme
DB06774CapsaicinGlutamine synthetaseenzyme
DB06774CapsaicinCholinesteraseenzyme
DB06774CapsaicinTransient receptor potential cation channel subfamily V member 1target
DB06774CapsaicinProhibitin-2target
DB00711DiethylcarbamazineArachidonate 5-lipoxygenasetarget
DB00711DiethylcarbamazineProstaglandin G/H synthase 1target
DB00711DiethylcarbamazineCholinesteraseenzyme
DB00585NizatidineHistamine H2 receptortarget
DB00585NizatidineP-glycoprotein 1transporter
DB00585NizatidineCholinesteraseenzyme
DB00082PegvisomantGrowth hormone receptortarget
DB00082PegvisomantSterol 26-hydroxylase, mitochondrialenzyme
DB00082PegvisomantGlutamine synthetaseenzyme
DB00082PegvisomantCytochrome P450 2C18enzyme
DB00082PegvisomantCytochrome P450 3A4enzyme
DB00082PegvisomantCholinesteraseenzyme
DB00082PegvisomantCytochrome P450 4A11enzyme
DB00790PerindoprilAngiotensin-converting enzymetarget
DB00790PerindoprilSolute carrier family 15 member 1transporter
DB00790PerindoprilSolute carrier family 15 member 2transporter
DB00790PerindoprilCholinesteraseenzyme
DB00790PerindoprilSecreted frizzled-related protein 4target
DB01338PipecuroniumNeuronal acetylcholine receptor subunit alpha-2target
DB01338PipecuroniumMuscarinic acetylcholine receptor M2target
DB01338PipecuroniumMuscarinic acetylcholine receptor M3target
DB01338PipecuroniumCholinesteraseenzyme
DB00515CisplatinDNAtarget
DB00515CisplatinCanalicular multispecific organic anion transporter 2transporter
DB00515CisplatinMultidrug resistance-associated protein 5transporter
DB00515CisplatinCanalicular multispecific organic anion transporter 1transporter
DB00515CisplatinSolute carrier family 22 member 2transporter
DB00515CisplatinHigh affinity copper uptake protein 1transporter
DB00515CisplatinProbable low affinity copper uptake protein 2transporter
DB00515CisplatinMultidrug resistance-associated protein 6transporter
DB00515CisplatinP-glycoprotein 1transporter
DB00515CisplatinCopper-transporting ATPase 2transporter
DB00515CisplatinCopper-transporting ATPase 1transporter
DB00515CisplatinProstaglandin G/H synthase 2enzyme
DB00515CisplatinMyeloperoxidaseenzyme
DB00515CisplatinXanthine dehydrogenase/oxidaseenzyme
DB00515CisplatinArylamine N-acetyltransferaseenzyme
DB00515CisplatinCytochrome P450 2C9enzyme
DB00515CisplatinCytochrome P450 2B6enzyme
DB00515CisplatinCholinesteraseenzyme
DB00515CisplatinCytochrome P450 4A11enzyme
DB00515CisplatinATP-binding cassette sub-family G member 2transporter
DB00515CisplatinGlutathione S-transferase theta-1enzyme
DB00515CisplatinMetallothionein-1Aenzyme
DB00515CisplatinMetallothionein-2enzyme
DB00515CisplatinSuperoxide dismutase [Cu-Zn]enzyme
DB00515CisplatinGlutathione S-transferase Penzyme
DB00515CisplatinNAD(P)H dehydrogenase [quinone] 1enzyme
DB00515CisplatinGlutathione S-transferase Mu 1enzyme
DB00515CisplatinDNA-3-methyladenine glycosylasetarget
DB00515CisplatinAlpha-2-macroglobulintarget
DB00515CisplatinSerum albumincarrier
DB00515CisplatinSerotransferrintarget
DB00515CisplatinCopper transport protein ATOX1target
DB00721ProcaineSodium channel protein type 10 subunit alphatarget
DB00721ProcaineGlutamate receptor ionotropic, NMDA 3Atarget
DB00721Procaine5-hydroxytryptamine receptor 3Atarget
DB00721ProcaineSodium-dependent dopamine transportertarget
DB00721ProcaineNeuronal acetylcholine receptor subunit alpha-2target
DB00721ProcaineCholinesteraseenzyme
DB00721ProcaineDNAtarget
DB00721ProcaineCalcium-activated potassium channeltarget
DB00721ProcaineCytosolic phospholipase A2target
DB00721Procaine60 kDa lysophospholipasetarget
DB00721ProcaineMonoamine oxidasetarget
DB00178RamiprilAngiotensin-converting enzymetarget
DB00178RamiprilSolute carrier family 15 member 1transporter
DB00178RamiprilSolute carrier family 15 member 2transporter
DB00178RamiprilCholinesteraseenzyme
DB00178RamiprilB1 bradykinin receptortarget
DB05386RegramostimGranulocyte-macrophage colony-stimulating factor receptor subunit alphatarget
DB05386RegramostimGM-CSF receptor alpha subunittarget
DB05386RegramostimCholinesteraseenzyme
DB00391SulpirideDopamine D2 receptortarget
DB00391SulpirideDopamine D3 receptortarget
DB00391SulpirideCholinesteraseenzyme
DB00391SulpirideCarbonic anhydrase 2target
DB00391SulpirideCarbonic anhydrase 3target
DB00508TriflupromazineDopamine D1 receptortarget
DB00508TriflupromazineDopamine D2 receptortarget
DB00508TriflupromazineMuscarinic acetylcholine receptor M1target
DB00508TriflupromazineMuscarinic acetylcholine receptor M2target
DB00508Triflupromazine5-hydroxytryptamine receptor 2Btarget
DB00508TriflupromazineP-glycoprotein 1transporter
DB00508TriflupromazineCholinesteraseenzyme
DB01221KetamineGlutamate receptor ionotropic, NMDA 3Atarget
DB01221KetamineNeurokinin 1 receptortarget
DB01221KetamineCytochrome P450 2B6enzyme
DB01221KetamineCytochrome P450 2C9enzyme
DB01221KetamineCytochrome P450 3A4enzyme
DB01221KetamineDopamine D2 receptortarget
DB01221KetamineProstaglandin G/H synthase 1enzyme
DB01221KetamineCytochrome P450 2C8enzyme
DB01221KetamineDelta-type opioid receptortarget
DB01221KetamineSodium-dependent noradrenaline transportertarget
DB01221KetamineKappa-type opioid receptortarget
DB01221KetamineMu-type opioid receptortarget
DB01221KetamineMuscarinic acetylcholine receptortarget
DB01221Ketamine5-hydroxytryptamine receptor 2target
DB01221Ketamine5-hydroxytryptamine receptor 1target
DB01221Ketamine5-hydroxytryptamine receptor 3Atarget
DB01221KetamineAlpha-7 nicotinic cholinergic receptor subunittarget
DB01221KetamineCholinesterasetarget
DB01221KetamineNitric oxide synthase, braintarget
DB01043MemantineCytochrome P450 2B6enzyme
DB01043MemantineSolute carrier family 22 member 2transporter
DB01043Memantine5-hydroxytryptamine receptor 3Atarget
DB01043MemantineAlpha-7 nicotinic cholinergic receptor subunittarget
DB01043MemantineCytochrome P450 2A6enzyme
DB01043MemantineCytochrome P450 2C19enzyme
DB01043MemantineDopamine D2 receptortarget
DB01043MemantineGlutamate receptor ionotropic, NMDA 1target
DB01043MemantineSodium/hydrogen exchanger 1transporter
DB01043MemantineSolute carrier family 22 member 4transporter
DB01043MemantineMultidrug and toxin extrusion protein 1transporter
DB01043MemantineGlutamate (NMDA) receptortarget
DB01043MemantineGABA-A receptor (anion channel)target
DB01043MemantineGlycine receptorstarget
DB00863RanitidineHistamine H2 receptortarget
DB00863RanitidineCytochrome P450 1A2enzyme
DB00863RanitidineCytochrome P450 2D6enzyme
DB00863RanitidineSolute carrier family 22 member 1transporter
DB00863RanitidineP-glycoprotein 1transporter
DB00863RanitidineSolute carrier family 22 member 8transporter
DB00863RanitidineCytochrome P450 3A4enzyme
DB00863RanitidineAcetylcholinesterasetarget
DB00863RanitidineSolute carrier family 22 member 2transporter
DB00863RanitidineCholinesterasetarget
DB00863RanitidineCholinesteraseenzyme
DB02845Methylphosphinic AcidEsterasetarget
DB02845Methylphosphinic AcidCholinesterasetarget
DB02845Methylphosphinic AcidAcetylcholinesterasetarget
DB02845Methylphosphinic AcidCholinesteraseenzyme