Cytochrome P-450 CYP3A4 Inhibitors (weak)

DrugDrug NameDrug Indication
DB00381AmlodipineFor the treatment of hypertension and chronic stable angina.
DB00404AlprazolamFor the management of anxiety disorder or the short-term relief of symptoms of anxiety and for the treatment of panic disorder, with or without agoraphobia.
DB00622NicardipineUsed for the management of patients with chronic stable angina and for the treatment of hypertension.
DB01076AtorvastatinMay be used as primary prevention in individuals with multiple risk factors for coronary heart disease (CHD) and as secondary prevention in individuals with CHD to reduce the risk of myocardial infarction (MI), stroke, angina, and revascularization procedures. May be used to reduce the risk of cardiovascular events in patients with acute coronary syndrome (ACS). May be used in the treatment of primary hypercholesterolemia and mixed dyslipidemia, homozygous familial hypercholesterolemia, primary dysbetalipoproteinemia, and/or hypertriglyeridemia as an adjunct to dietary therapy to decrease serum total and low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (apoB), and triglyceride concentrations, while increasing high-density lipoprotein cholesterol (HDL-C) levels.
DB01166CilostazolFor the reduction of symptoms of intermittent claudication (pain in the legs that occurs with walking and disappears with rest).
DB01254DasatinibFor the treatment of adults with chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia with resistance or intolerance to prior therapy. Also indicated for the treatment of adults with Philadelphia chromosome-positive acute lymphoblastic leukemia with resistance or intolerance to prior therapy.
DB01259LapatinibIndicated in combination with capecitabine for the treatment of patients with advanced or metastatic breast cancer whose tumors overexpress the human epidermal receptor type 2 (HER2) protein and who have received prior therapy including an anthracycline, a taxane, and trastuzuma.
DB00908QuinidineFor the treatment of ventricular pre-excitation and cardiac dysrhythmias
DB00501CimetidineFor the treatment and the management of acid-reflux disorders (GERD), peptic ulcer disease, heartburn, and acid indigestion.
DB00537CiprofloxacinFor the treatment of the following infections caused by susceptible organisms: urinary tract infections, acute uncomplicated cystitis, chronic bacterial prostatitis, lower respiratory tract infections, acute sinusitis, skin and skin structure infections, bone and joint infections, complicated intra-abdominal infections (used in combination with metronidazole), infectious diarrhea, typhoid fever (enteric fever), uncomplicated cervical and urethral gonorrhea, and inhalational anthrax (post-exposure).
DB06589PazopanibTreatment of advanced renal cell cancer and advanced soft tissue sarcoma (in patients previously treated with chemotherapy)
DB01128BicalutamideFor treatment (together with surgery or LHRH analogue) of advanced prostatic cancer.
DB00951IsoniazidFor the treatment of all forms of tuberculosis in which organisms are susceptible.
DB01406DanazolFor the treatment of endometriosis and fibrocystic breast disease (in patients unresponsive to simple measures). Also used for the prophylactic treatment of all types of hereditary angioedema in males and females.
DB00818PropofolUsed for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.
DB04946IloperidoneTreatment of acute schizophrenia.
DB08820IvacaftorWhen used as monotherapy as the product Kalydeco, ivacaftor is indicated for the managmenet of CF in patients age 2 years and older who have a mutation in the CFTR gene that is responsive to ivacaftor potentiation. Ivacaftor received expanded approval in May 2017 for the following 33 CFTR mutations: E56K, P67L, R74W, D110E, D110H, R117C, R117H, G178R, E193K, L206W, R347H, R352Q, A455E, S549N, S549R, G551D, G551S, D579G, S945L, S977F, F1052V, K1060T, A1067T, G1069R, R1070Q, R1070W, F1074L, D1152H, G1244E, S1251N, S1255P, D1270N, and G1349D [L768, FDA Label]. When used in combination with the drug [DB09280] as the product Orkambi, ivacaftor is indicated for the management of CF patients age 6 years and older who are homozygous for the F508del mutation in the CFTR gene.
DB08816TicagrelorFor the prevention of thrombotic events (for example stroke or heart attack) in patients with acute coronary syndrome or myocardial infarction with ST elevation.
DB01764DalfopristinFor the treatment of bacterial infections (usually in combination with quinupristin).
DB01369QuinupristinFor the treatment of bacterial infections (usually in combination with dalfopristin).
DB08827LomitapideUsed in homozygous familial hypercholesterolemia (HoFH) patients to reduce low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), apolipoprotein B (apo B), and non-high-density lipoprotein cholesterol (non-HDL-C).
DB08815LurasidoneTreatment of schizophrenia.
DB09073PalbociclibPalbociclib is indicated in combination with letrozole for the treatment of postmenopausal women with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer as initial endocrine-based therapy for their metastatic disease. This indication is approved under accelerated approval based on progression-free survival (PFS). Continued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory trial.
DB06717FosaprepitantFor the prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy.
DB08909Glycerol PhenylbutyrateGlycerol phenylbutyrate is a nitrogen-binding agent for the chronic management of adult and pediatric patients ≥2 years of age with urea cycle disorders (UCDs) who cannot be managed by dietary protein restriction and/or amino acid supplementation alone.
DB09120ZucapsaicinIndicated to be used in conjunction with oral COX-2 inhibitors or NSAIDs for the relief of severe pain in adult patients with osteoarthritis of the knee, not controlled with oral COX-2 inhibitors or NSAIDs alone, for a duration of no more than three months.
DB09238ManidipineFor the treatment of hypertension.
DB11767SarilumabIndicated for modere to severe reactive RA in adult patients who are irresponsive, respond inadequately or present intolerance to disease-modifying anti-rheumatic drugs (DMARDs) or tumor necrosis factor (TNF) antagonists. It is indicated to be used in combination with methotrexate (MTX) or as a monotherapy when there is intolerance to MTX or MTX administration is inappropriate.
DrugDrug NameTargetType
DB00381AmlodipineCarbonic anhydrase 1target
DB00381AmlodipineCytochrome P450 3A4enzyme
DB00381AmlodipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB00381AmlodipineVoltage-dependent L-type calcium channel subunit beta-2target
DB00381AmlodipineCytochrome P450 1A1enzyme
DB00381AmlodipineCytochrome P450 2B6enzyme
DB00381AmlodipineVoltage-dependent N-type calcium channel subunit alpha-1Btarget
DB00381AmlodipineVoltage-dependent calcium channel subunit alpha-2/delta-1target
DB00381AmlodipineVoltage-gated calcium channel beta 1 subunit splice variant CavB1dtarget
DB00381AmlodipineVoltage-dependent calcium channel subunit alpha-2/delta-3target
DB00381AmlodipineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
DB00381AmlodipineVoltage-dependent L-type calcium channel subunit alpha-1Starget
DB00381AmlodipineCytochrome P450 3A5enzyme
DB00381AmlodipineCytochrome P450 3A7enzyme
DB00381AmlodipineCytochrome P450 1A2enzyme
DB00381AmlodipineMultidrug resistance protein 1transporter
DB00381AmlodipineCytochrome P450 2A6enzyme
DB00381AmlodipineCytochrome P450 2C8enzyme
DB00381AmlodipineCytochrome P450 2C9enzyme
DB00381AmlodipineCytochrome P450 2D6enzyme
DB00381AmlodipineSphingomyelin phosphodiesterasetarget
DB00404AlprazolamCytochrome P450 3A4enzyme
DB00404AlprazolamCytochrome P450 2C9enzyme
DB00404AlprazolamCytochrome P450 3A5enzyme
DB00404AlprazolamCytochrome P450 3A7enzyme
DB00404AlprazolamGABA-A receptor (anion channel)target
DB00622NicardipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB00622NicardipineCytochrome P450 3A4enzyme
DB00622NicardipineCytochrome P450 2C9enzyme
DB00622NicardipineCytochrome P450 2C19enzyme
DB00622NicardipineCytochrome P450 2C8enzyme
DB00622NicardipineCytochrome P450 2D6enzyme
DB00622NicardipineCalcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1Btarget
DB00622NicardipineCalcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1Atarget
DB00622NicardipineAlpha-1A adrenergic receptortarget
DB00622NicardipineAlpha-1D adrenergic receptortarget
DB00622NicardipineAlpha-1B adrenergic receptortarget
DB00622NicardipineMuscarinic acetylcholine receptor M1target
DB00622NicardipineMuscarinic acetylcholine receptor M2target
DB00622NicardipineMuscarinic acetylcholine receptor M3target
DB00622NicardipineMuscarinic acetylcholine receptor M4target
DB00622NicardipineMuscarinic acetylcholine receptor M5target
DB00622NicardipineVoltage-dependent calcium channel subunit alpha-2/delta-1target
DB00622NicardipineVoltage-dependent L-type calcium channel subunit beta-2target
DB00622NicardipineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
DB00622NicardipineCalmodulintarget
DB00622NicardipineMultidrug resistance protein 1transporter
DB00622NicardipineCytochrome P450 2B6enzyme
DB00622NicardipineCytochrome P450 2E1enzyme
DB00622NicardipineCytochrome P450 3A5enzyme
DB01076Atorvastatin3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
DB01076AtorvastatinCytochrome P450 3A4enzyme
DB01076AtorvastatinDipeptidyl peptidase 4target
DB01076AtorvastatinCytochrome P450 2D6enzyme
DB01076AtorvastatinCytochrome P450 2C9enzyme
DB01076AtorvastatinCytochrome P450 2C19enzyme
DB01076AtorvastatinCytochrome P450 3A5enzyme
DB01076AtorvastatinCytochrome P450 3A7enzyme
DB01076AtorvastatinMultidrug resistance protein 1transporter
DB01076AtorvastatinSolute carrier organic anion transporter family member 1A2transporter
DB01076AtorvastatinSolute carrier organic anion transporter family member 1B1transporter
DB01076AtorvastatinMultidrug resistance-associated protein 4transporter
DB01076AtorvastatinMultidrug resistance-associated protein 5transporter
DB01076AtorvastatinMultidrug resistance-associated protein 1transporter
DB01076AtorvastatinCytochrome P450 2B6enzyme
DB01076AtorvastatinCytochrome P450 2C8enzyme
DB01076AtorvastatinAryl hydrocarbon receptortarget
DB01076AtorvastatinSolute carrier organic anion transporter family member 2B1transporter
DB01076AtorvastatinSolute carrier organic anion transporter family member 1B3transporter
DB01076AtorvastatinUDP-glucuronosyltransferase 1-1enzyme
DB01076AtorvastatinUDP-glucuronosyltransferase 1-3enzyme
DB01076AtorvastatinUDP-glucuronosyltransferase 2B7enzyme
DB01076AtorvastatinCanalicular multispecific organic anion transporter 1transporter
DB01166CilostazolcGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
DB01166CilostazolCytochrome P450 2C19enzyme
DB01166CilostazolCytochrome P450 3A4enzyme
DB01166CilostazolCytochrome P450 3A5enzyme
DB01166CilostazolCytochrome P450 3A7enzyme
DB01166CilostazolCytochrome P450 1A2enzyme
DB01166CilostazolCytochrome P450 2D6enzyme
DB01254DasatinibTyrosine-protein kinase ABL1target
DB01254DasatinibAbelson tyrosine-protein kinase 2target
DB01254DasatinibProto-oncogene tyrosine-protein kinase Srctarget
DB01254DasatinibTyrosine-protein kinase Fyntarget
DB01254DasatinibTyrosine-protein kinase Lcktarget
DB01254DasatinibTyrosine-protein kinase Yestarget
DB01254DasatinibMast/stem cell growth factor receptor Kittarget
DB01254DasatinibPlatelet-derived growth factor receptor betatarget
DB01254DasatinibEphrin type-A receptor 2target
DB01254DasatinibSignal transducer and activator of transcription 5Btarget
DB01254DasatinibCytochrome P450 3A4enzyme
DB01254DasatinibMultidrug resistance protein 1transporter
DB01254DasatinibATP-binding cassette sub-family G member 2transporter
DB01254DasatinibCytochrome P450 1A1enzyme
DB01254DasatinibCytochrome P450 1A2enzyme
DB01254DasatinibCytochrome P450 1B1enzyme
DB01254DasatinibCytochrome P450 3A5enzyme
DB01254DasatinibDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB01254DasatinibTyrosine-protein kinase BTKtarget
DB01254DasatinibNuclear receptor subfamily 4 group A member 3target
DB01254DasatinibBreakpoint cluster region proteintarget
DB01254DasatinibTyrosine-protein kinase CSKtarget
DB01254DasatinibEphrin type-A receptor 5target
DB01254DasatinibEphrin type-B receptor 4target
DB01254DasatinibTyrosine-protein kinase Fgrtarget
DB01254DasatinibTyrosine-protein kinase FRKtarget
DB01254DasatinibHeat shock cognate 71 kDa proteintarget
DB01254DasatinibTyrosine-protein kinase Lyntarget
DB01254DasatinibMitogen-activated protein kinase kinase kinase MLTtarget
DB01254DasatinibMitogen-activated protein kinase 14target
DB01254DasatinibAmidophosphoribosyltransferasetarget
DB01259LapatinibEpidermal growth factor receptortarget
DB01259LapatinibReceptor tyrosine-protein kinase erbB-2target
DB01259LapatinibCytochrome P450 3A4enzyme
DB01259LapatinibCytochrome P450 2C8enzyme
DB01259LapatinibMultidrug resistance protein 1transporter
DB01259LapatinibAntigen peptide transporter 1transporter
DB01259LapatinibCytochrome P450 3A5enzyme
DB01259LapatinibCytochrome P450 2C19enzyme
DB00908QuinidineSodium channel protein type 5 subunit alphatarget
DB00908QuinidineAlpha-1-acid glycoprotein 1carrier
DB00908QuinidinePotassium voltage-gated channel subfamily H member 2target
DB00908QuinidinePotassium channel subfamily K member 1target
DB00908QuinidinePotassium channel subfamily K member 6target
DB00908QuinidineCytochrome P450 1A2enzyme
DB00908QuinidineCytochrome P450 2E1enzyme
DB00908QuinidineCytochrome P450 1A1enzyme
DB00908QuinidineCytochrome P450 2D6enzyme
DB00908QuinidineCytochrome P450 3A4enzyme
DB00908QuinidineCytochrome P450 3A7enzyme
DB00908QuinidineSolute carrier family 22 member 2transporter
DB00908QuinidineSolute carrier family 22 member 1transporter
DB00908QuinidineSolute carrier family 22 member 5transporter
DB00908QuinidineBile salt export pumptransporter
DB00908QuinidineMultidrug resistance protein 1transporter
DB00908QuinidineSolute carrier organic anion transporter family member 1A2transporter
DB00908QuinidineSolute carrier family 22 member 8transporter
DB00908QuinidineCanalicular multispecific organic anion transporter 1transporter
DB00908QuinidineSolute carrier family 22 member 4transporter
DB00908QuinidineSolute carrier organic anion transporter family member 1B1transporter
DB00908QuinidineCytochrome P450 2B6enzyme
DB00908QuinidineCytochrome P450 2C8enzyme
DB00908QuinidineCytochrome P450 2C9enzyme
DB00908QuinidineAlpha-1A adrenergic receptortarget
DB00908QuinidineAlpha-1B adrenergic receptortarget
DB00908QuinidineAlpha-1D adrenergic receptortarget
DB00501CimetidineHistamine H2 receptortarget
DB00501CimetidineCytochrome P450 1A2enzyme
DB00501CimetidineCytochrome P450 2D6enzyme
DB00501CimetidineCytochrome P450 2C19enzyme
DB00501CimetidineCytochrome P450 3A4enzyme
DB00501CimetidineCytochrome P450 3A5enzyme
DB00501CimetidineCytochrome P450 3A7enzyme
DB00501CimetidineMultidrug resistance protein 1transporter
DB00501CimetidineSolute carrier family 22 member 2transporter
DB00501CimetidineSolute carrier family 22 member 1transporter
DB00501CimetidineSolute carrier family 22 member 3transporter
DB00501CimetidineSolute carrier family 22 member 5transporter
DB00501CimetidineBile salt export pumptransporter
DB00501CimetidineSolute carrier family 22 member 6transporter
DB00501CimetidineSolute carrier family 22 member 8transporter
DB00501CimetidineMultidrug and toxin extrusion protein 1transporter
DB00501CimetidineSolute carrier family 22 member 4transporter
DB00501CimetidineSolute carrier family 22 member 11transporter
DB00501CimetidineSolute carrier family 22 member 7transporter
DB00501CimetidineCytochrome P450 11B1, mitochondrialenzyme
DB00501CimetidineCytochrome P450 2C8enzyme
DB00501CimetidineCytochrome P450 2C9enzyme
DB00501CimetidineCytochrome P450 2E1enzyme
DB00501CimetidineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB00501CimetidineDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
DB00537CiprofloxacinDNA gyrase subunit Atarget
DB00537CiprofloxacinDNA topoisomerase 4 subunit Atarget
DB00537CiprofloxacinDNA topoisomerase 2-alphatarget
DB00537CiprofloxacinCytochrome P450 1A2enzyme
DB00537CiprofloxacinCytochrome P450 3A4enzyme
DB00537CiprofloxacinCytochrome P450 3A5enzyme
DB00537CiprofloxacinCytochrome P450 3A7enzyme
DB00537CiprofloxacinMultidrug resistance protein 1transporter
DB00537CiprofloxacinPotassium voltage-gated channel subfamily H member 2target
DB00537CiprofloxacinDNA gyrase subunit Atarget
DB00537CiprofloxacinDNA topoisomerase 4 subunit Atarget
DB00537CiprofloxacinDNA topoisomerase 4 subunit Btarget
DB00537CiprofloxacinDNA gyrase subunit Atarget
DB00537CiprofloxacinMultidrug resistance protein MdtKtarget
DB00537CiprofloxacinGyrase Atarget
DB00537CiprofloxacinDNA gyrase subunit Atarget
DB06589PazopanibVascular endothelial growth factor receptor 1target
DB06589PazopanibVascular endothelial growth factor receptor 2target
DB06589PazopanibVascular endothelial growth factor receptor 3target
DB06589PazopanibPlatelet-derived growth factor receptor alphatarget
DB06589PazopanibPlatelet-derived growth factor receptor betatarget
DB06589PazopanibMast/stem cell growth factor receptor Kittarget
DB06589PazopanibCytochrome P450 3A4enzyme
DB06589PazopanibCytochrome P450 2D6enzyme
DB06589PazopanibCytochrome P450 2C8enzyme
DB06589PazopanibCytochrome P450 1A2enzyme
DB06589PazopanibMultidrug resistance protein 1transporter
DB06589PazopanibATP-binding cassette sub-family G member 2transporter
DB06589PazopanibSolute carrier organic anion transporter family member 1B1transporter
DB06589PazopanibUDP-glucuronosyltransferase 1-1transporter
DB06589PazopanibFibroblast growth factor receptor 3target
DB06589PazopanibTyrosine-protein kinase ITK/TSKtarget
DB06589PazopanibFibroblast growth factor 1target
DB06589PazopanibSH2B adapter protein 3target
DB01128BicalutamideAndrogen receptortarget
DB01128BicalutamideCytochrome P450 3A4enzyme
DB01128BicalutamideCytochrome P450 2C19enzyme
DB01128BicalutamideCytochrome P450 2C9enzyme
DB01128BicalutamideCytochrome P450 2D6enzyme
DB00951IsoniazidCatalase-peroxidasetarget
DB00951IsoniazidEnoyl-[acyl-carrier-protein] reductase [NADH]target
DB00951IsoniazidCytochrome P450 2E1enzyme
DB00951IsoniazidCytochrome P450 1A2enzyme
DB00951IsoniazidCytochrome P450 2C9enzyme
DB00951IsoniazidCytochrome P450 2D6enzyme
DB00951IsoniazidCytochrome P450 2C19enzyme
DB00951IsoniazidCytochrome P450 3A4enzyme
DB00951IsoniazidArylamine N-acetyltransferase 2enzyme
DB00951IsoniazidArylamine N-acetyltransferaseenzyme
DB00951IsoniazidCytochrome P450 2A6enzyme
DB00951IsoniazidCytochrome P450 2C8enzyme
DB00951IsoniazidCytochrome P450 2C8target
DB00951IsoniazidCytochrome P450 1A2target
DB00951IsoniazidCytochrome P450 3A4target
DB00951IsoniazidCytochrome P450 2C19target
DB00951IsoniazidDihydrofolate reductasetarget
DB00951IsoniazidSerum albumincarrier
DB01406DanazolEstrogen receptor alphatarget
DB01406DanazolGonadotropin-releasing hormone receptortarget
DB01406DanazolPutative gonadotropin-releasing hormone II receptortarget
DB01406DanazolSex hormone-binding globulincarrier
DB01406DanazolC-C motif chemokine 2target
DB01406DanazolCytochrome P450 19A1enzyme
DB01406DanazolAndrogen receptortarget
DB01406DanazolProgesterone receptortarget
DB01406DanazolCytochrome P450 3A4enzyme
DB00818PropofolCytochrome P450 2B6enzyme
DB00818PropofolUDP-glucuronosyltransferase 1-1enzyme
DB00818PropofolUDP-glucuronosyltransferase 1-9enzyme
DB00818PropofolGamma-aminobutyric acid receptor subunit beta-2target
DB00818PropofolGamma-aminobutyric acid receptor subunit beta-3target
DB00818PropofolSerum albumincarrier
DB00818PropofolSodium channel protein type 4 subunit alphatarget
DB00818PropofolSodium channel protein type 2 subunit alphatarget
DB00818PropofolFatty-acid amide hydrolase 1enzyme
DB00818PropofolCytochrome P450 2C9enzyme
DB00818PropofolUDP-glucuronosyltransferase 1-8enzyme
DB00818PropofolCytochrome P450 2E1enzyme
DB00818PropofolCytochrome P450 1B1enzyme
DB00818PropofolCytochrome P450 1A1enzyme
DB00818PropofolCytochrome P450 1A2enzyme
DB00818PropofolCytochrome P450 2A6enzyme
DB00818PropofolCytochrome P450 2C18enzyme
DB00818PropofolCytochrome P450 2C19enzyme
DB00818PropofolCytochrome P450 2C8enzyme
DB00818PropofolCytochrome P450 2D6enzyme
DB00818PropofolCytochrome P450 3A4enzyme
DB00818PropofolUDP-glucuronosyltransferase 1-6enzyme
DB00818PropofolGABA-A receptor (anion channel)target
DB04946IloperidoneD(2) dopamine receptortarget
DB04946Iloperidone5-hydroxytryptamine receptor 2Atarget
DB04946IloperidoneCytochrome P450 2D6enzyme
DB04946IloperidoneCytochrome P450 3A4enzyme
DB04946IloperidoneCytochrome P450 3A5enzyme
DB04946IloperidoneCytochrome P450 3A7enzyme
DB04946IloperidoneCytochrome P450 2E1enzyme
DB04946IloperidoneD(3) dopamine receptortarget
DB04946IloperidoneAlpha-1A adrenergic receptortarget
DB04946IloperidoneD(4) dopamine receptortarget
DB04946Iloperidone5-hydroxytryptamine receptor 6target
DB04946Iloperidone5-hydroxytryptamine receptor 7target
DB04946IloperidoneHistamine H1 receptortarget
DB04946IloperidoneD(1A) dopamine receptortarget
DB04946Iloperidone5-hydroxytryptamine receptor 1Atarget
DB04946IloperidoneCytochrome P450 1A2enzyme
DB04946IloperidoneAlpha-2C adrenergic receptortarget
DB08820IvacaftorCystic fibrosis transmembrane conductance regulatortarget
DB08820IvacaftorCytochrome P450 3A4enzyme
DB08820IvacaftorSerum albumincarrier
DB08820IvacaftorAlpha-1-acid glycoprotein 1carrier
DB08820IvacaftorMultidrug resistance protein 1transporter
DB08820IvacaftorCytochrome P450 3A5enzyme
DB08816TicagrelorCytochrome P450 3A4enzyme
DB08816TicagrelorP2Y purinoceptor 12target
DB08816TicagrelorMultidrug resistance protein 1transporter
DB08816TicagrelorCytochrome P450 2D6enzyme
DB08816TicagrelorCytochrome P450 2C9enzyme
DB01764DalfopristinStreptogramin A acetyltransferasetarget
DB01764DalfopristinCytochrome P450 3A4enzyme
DB01369Quinupristin23S rRNAtarget
DB01369Quinupristin50S ribosomal protein L10target
DB01369Quinupristin50S ribosomal protein L22target
DB01369QuinupristinCytochrome P450 3A4enzyme
DB08827LomitapideMicrosomal triglyceride transfer protein large subunittarget
DB08827LomitapideCytochrome P450 3A4enzyme
DB08827LomitapideMultidrug resistance protein 1transporter
DB08815LurasidoneCytochrome P450 3A4enzyme
DB08815LurasidoneD(2) dopamine receptortarget
DB08815Lurasidone5-hydroxytryptamine receptor 2Atarget
DB08815Lurasidone5-hydroxytryptamine receptor 7target
DB08815Lurasidone5-hydroxytryptamine receptor 1Atarget
DB08815LurasidoneAlpha-2C adrenergic receptortarget
DB08815LurasidoneAlpha-2A adrenergic receptortarget
DB09073PalbociclibCyclin-dependent kinase 4target
DB09073PalbociclibCyclin-dependent kinase 6target
DB09073PalbociclibCytochrome P450 3A4enzyme
DB09073PalbociclibSulfotransferase 2A1enzyme
DB06717FosaprepitantCytochrome P450 3A4enzyme
DB08909Glycerol PhenylbutyratePancreatic triacylglycerol lipaseenzyme
DB08909Glycerol PhenylbutyrateCytochrome P450 3A4enzyme
DB08909Glycerol PhenylbutyrateCytochrome P450 1A2enzyme
DB08909Glycerol PhenylbutyrateCytochrome P450 2D6enzyme
DB09120ZucapsaicinTransient receptor potential cation channel subfamily V member 1target
DB09120ZucapsaicinCytochrome P450 1A2enzyme
DB09120ZucapsaicinCytochrome P450 2C19enzyme
DB09120ZucapsaicinCytochrome P450 2C9enzyme
DB09120ZucapsaicinCytochrome P450 2D6enzyme
DB09120ZucapsaicinCytochrome P450 2E1enzyme
DB09120ZucapsaicinCytochrome P450 3A4enzyme
DB09238ManidipineVoltage dependent L type calcium channeltarget
DB09238ManidipineVoltage-dependent T-type calcium channeltarget
DB09238ManidipineCytochrome P450 2C9enzyme
DB09238ManidipineCytochrome P450 2D6enzyme
DB09238ManidipineCytochrome P450 1A1enzyme
DB09238ManidipineCytochrome P450 1A2enzyme
DB09238ManidipineCytochrome P450 2B6enzyme
DB09238ManidipineCytochrome P450 2C19enzyme
DB09238ManidipineCytochrome P450 3A4enzyme
DB11767SarilumabAlanine aminotransferase 1enzyme
DB11767SarilumabAlanine aminotransferase 2enzyme
DB11767SarilumabAspartate aminotransferaseenzyme
DB11767SarilumabCytochrome P450 3A4enzyme
DB11767SarilumabInterleukin-6 receptor subunit alphatarget
DB11767SarilumabHigh affinity immunoglobulin gamma Fc receptor Itarget
DB11767SarilumabLow affinity immunoglobulin gamma Fc region receptor II-atarget
DB11767SarilumabLow affinity immunoglobulin gamma Fc region receptor II-btarget
DB11767SarilumabLow affinity immunoglobulin gamma Fc region receptor III-Atarget
DB11767SarilumabLow affinity immunoglobulin gamma Fc region receptor III-Btarget