Identification
NameFidaxomicin
Accession NumberDB08874
TypeSmall Molecule
GroupsApproved
Description

One of the first narrow spectrum macrocyclic antibiotic, it is a natural compound and is structurally similar to compounds in lipiarmycin-a fermentation mixture. FDA approved on May 27, 2011.

Structure
Thumb
Synonyms
Difimicin
Lipiarmicin
Lipiarmycin
Lipiarrmycin
Tiacumicin B
External IDs OPT 80 / OPT-80 / PAR 101 / PAR-101
Product Ingredients Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
DificidTablet, film coated200 mg/1OralMerck Sharp & Dohme Limited2011-05-27Not applicableUs
DificidTablet, film coated200 mg/1OralAvera Mc Kennan Hospital2015-04-17Not applicableUs
DificidTablet200 mgOralMerck Ltd.2012-06-21Not applicableCanada
DificlirTablet, film coated200 mgOralAstellas Pharma Europe Bv2011-12-05Not applicableEu
DificlirTablet, film coated200 mgOralAstellas Pharma Europe Bv2011-12-05Not applicableEu
DificlirTablet, film coated200 mgOralAstellas Pharma Europe Bv2011-12-05Not applicableEu
DificlirTablet, film coated200 mgOralAstellas Pharma Europe Bv2011-12-05Not applicableEu
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
Categories
UNIIZ5N076G8YQ
CAS number873857-62-6
WeightAverage: 1058.039
Monoisotopic: 1056.425220978
Chemical FormulaC52H74Cl2O18
InChI KeyZVGNESXIJDCBKN-KFGPIHIUSA-N
InChI
InChI=1S/C52H74Cl2O18/c1-13-30-22-26(6)33(56)18-16-15-17-31(23-66-51-45(65-12)42(61)44(29(9)67-51)69-49(64)35-32(14-2)36(53)39(58)37(54)38(35)57)48(63)68-34(28(8)55)20-19-25(5)21-27(7)43(30)70-50-41(60)40(59)46(52(10,11)72-50)71-47(62)24(3)4/h15-17,19,21-22,24,28-30,33-34,40-46,50-51,55-61H,13-14,18,20,23H2,1-12H3/b16-15+,25-19+,26-22+,27-21+,31-17+/t28-,29-,30+,33+,34?,40-,41+,42+,43+,44-,45+,46+,50-,51-/m1/s1
IUPAC Name
(2R,3S,4S,5S,6R)-6-{[(3E,5E,8S,9E,11S,12R,13E,15E)-12-{[(2R,3S,4R,5S)-3,4-dihydroxy-6,6-dimethyl-5-[(2-methylpropanoyl)oxy]oxan-2-yl]oxy}-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyl-2-oxo-1-oxacyclooctadeca-3,5,9,13,15-pentaen-3-yl]methoxy}-4-hydroxy-5-methoxy-2-methyloxan-3-yl 3,5-dichloro-2-ethyl-4,6-dihydroxybenzoate
SMILES
CC[[email protected]]1\C=C(C)\[[email protected]@H](O)C\C=C\C=C(CO[[email protected]@H]2O[[email protected]](C)[[email protected]@H](OC(=O)C3=C(CC)C(Cl)=C(O)C(Cl)=C3O)[[email protected]](O)[[email protected]@H]2OC)\C(=O)OC(C\C=C(/C)\C=C(C)\[[email protected]@H]1O[[email protected]@H]1OC(C)(C)[[email protected]@H](OC(=O)C(C)C)[[email protected]](O)[[email protected]@H]1O)[[email protected]@H](C)O
Pharmacology
Indication

Treatment of Clostridium difficile-associated diarrhea

Structured Indications
Pharmacodynamics

The minimum inhibitory concentration for 90% of organisms for fidaxomicin against C. difficile is 0.9978 to 2 µg/mL.

Mechanism of action

Fidaxomicin is a bactericidal-type antibiotic that inhibits RNA polymerase sigma subunit. RNA polymerase is responsible for transcription in the bacteria therefore fidaxomicin will inhibit protein synthesis. As a result, apoptosis is triggered in susceptible organisms such as C. difficile.

TargetKindPharmacological actionActionsOrganismUniProt ID
RNA polymerase sigma factorProteinyes
inhibitor
Clostridium difficile (strain 630)Q18BX5 details
Related Articles
Absorption

Fidaxomicin is not systemically absorbed as shown by a plasma concentrations below the lower limit of quantification after single-dose or multiple-dose. In contrast, fecal concentrations of fidaxomicin are much higher and are concentration-dependent. Cmax = 2 hours; Tmax = 5.2 ng/mL; AUC = 14 ng•hr/mL

Volume of distribution

Fidaxomicin is largely confined in the gastrointestinal tract and is not distributed extensively in the systemic.

Protein bindingNot Available
Metabolism

Fidaxomicin is hydrolyzed by gastric acid or intestinal microsomes into a less active metabolite (OP-1118). The cytochrome enzyme system are not involved in the metabolism of fidaxomicin.

SubstrateEnzymesProduct
Fidaxomicin
Not Available
OP-1118Details
Route of elimination

Feces (>92% as unchanged drugs and metabolites) and urine (<1% of drug was excreted)

Half life

200 mg, healthy subjects = 11.7 hours

ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Gram-positive Bacteria
  • Peptoclostridium difficile
PathwaysNot Available
Pharmacogenomic Effects/ADRs Not Available
Interactions
Drug Interactions
DrugInteractionDrug group
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Fidaxomicin.Approved
AcetaminophenThe serum concentration of Fidaxomicin can be increased when it is combined with Acetaminophen.Approved
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Fidaxomicin.Approved, Vet Approved
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Fidaxomicin.Approved
AlbendazoleThe serum concentration of Fidaxomicin can be increased when it is combined with Albendazole.Approved, Vet Approved
AldosteroneThe serum concentration of Fidaxomicin can be decreased when it is combined with Aldosterone.Experimental
AlectinibThe serum concentration of Fidaxomicin can be increased when it is combined with Alectinib.Approved
AlfentanilThe serum concentration of Fidaxomicin can be increased when it is combined with Alfentanil.Approved, Illicit
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Fidaxomicin.Approved, Investigational
AmantadineThe serum concentration of Fidaxomicin can be increased when it is combined with Amantadine.Approved
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Fidaxomicin.Approved, Investigational
Aminohippuric acidThe serum concentration of Fidaxomicin can be increased when it is combined with Aminohippuric acid.Approved
AmiodaroneThe serum concentration of Fidaxomicin can be decreased when it is combined with Amiodarone.Approved, Investigational
AmitriptylineThe serum concentration of Fidaxomicin can be increased when it is combined with Amitriptyline.Approved
AmlodipineThe serum concentration of Fidaxomicin can be increased when it is combined with Amlodipine.Approved
AmprenavirThe serum concentration of Fidaxomicin can be decreased when it is combined with Amprenavir.Approved
AmsacrineThe serum concentration of Fidaxomicin can be increased when it is combined with Amsacrine.Approved
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Fidaxomicin.Approved
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Fidaxomicin.Approved, Investigational
AstemizoleThe serum concentration of Fidaxomicin can be increased when it is combined with Astemizole.Approved, Withdrawn
AtazanavirThe serum concentration of Fidaxomicin can be increased when it is combined with Atazanavir.Approved, Investigational
AtenololThe serum concentration of Fidaxomicin can be increased when it is combined with Atenolol.Approved
AtorvastatinThe serum concentration of Fidaxomicin can be increased when it is combined with Atorvastatin.Approved
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Fidaxomicin.Approved, Investigational
AzelastineThe serum concentration of Fidaxomicin can be increased when it is combined with Azelastine.Approved
AzithromycinThe serum concentration of Fidaxomicin can be increased when it is combined with Azithromycin.Approved
BCG vaccineThe therapeutic efficacy of Bcg can be decreased when used in combination with Fidaxomicin.Investigational
BenzocaineThe serum concentration of Fidaxomicin can be increased when it is combined with Benzocaine.Approved
BepridilThe serum concentration of Fidaxomicin can be increased when it is combined with Bepridil.Approved, Withdrawn
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Fidaxomicin.Approved, Vet Approved
BiperidenThe serum concentration of Fidaxomicin can be increased when it is combined with Biperiden.Approved
BoceprevirThe serum concentration of Boceprevir can be increased when it is combined with Fidaxomicin.Withdrawn
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Fidaxomicin.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Fidaxomicin.Approved
BromocriptineThe serum concentration of Fidaxomicin can be increased when it is combined with Bromocriptine.Approved, Investigational
BuprenorphineThe serum concentration of Fidaxomicin can be increased when it is combined with Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe serum concentration of Fidaxomicin can be increased when it is combined with Buspirone.Approved, Investigational
CabazitaxelThe serum concentration of Fidaxomicin can be increased when it is combined with Cabazitaxel.Approved
CaffeineThe serum concentration of Fidaxomicin can be increased when it is combined with Caffeine.Approved
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Fidaxomicin.Experimental
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Fidaxomicin.Approved
CandesartanThe serum concentration of Fidaxomicin can be increased when it is combined with Candesartan.Approved
CaptoprilThe serum concentration of Fidaxomicin can be increased when it is combined with Captopril.Approved
CarbamazepineThe serum concentration of Fidaxomicin can be decreased when it is combined with Carbamazepine.Approved, Investigational
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Fidaxomicin.Approved
CarvedilolThe serum concentration of Fidaxomicin can be increased when it is combined with Carvedilol.Approved, Investigational
CaspofunginThe serum concentration of Fidaxomicin can be increased when it is combined with Caspofungin.Approved
CeritinibThe serum concentration of Ceritinib can be increased when it is combined with Fidaxomicin.Approved
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Fidaxomicin.Withdrawn
ChloroquineThe serum concentration of Fidaxomicin can be increased when it is combined with Chloroquine.Approved, Vet Approved
ChlorpromazineThe serum concentration of Fidaxomicin can be increased when it is combined with Chlorpromazine.Approved, Vet Approved
ChlorpropamideThe serum concentration of Fidaxomicin can be increased when it is combined with Chlorpropamide.Approved
ChlorprothixeneThe serum concentration of Fidaxomicin can be increased when it is combined with Chlorprothixene.Approved, Withdrawn
CholesterolThe serum concentration of Fidaxomicin can be increased when it is combined with Cholesterol.Experimental
Cholic AcidThe serum concentration of Fidaxomicin can be decreased when it is combined with Cholic Acid.Approved
CilazaprilThe serum concentration of Fidaxomicin can be increased when it is combined with Cilazapril.Approved
CimetidineThe serum concentration of Fidaxomicin can be decreased when it is combined with Cimetidine.Approved
CiprofloxacinThe serum concentration of Fidaxomicin can be increased when it is combined with Ciprofloxacin.Approved, Investigational
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Fidaxomicin.Approved
CitalopramThe serum concentration of Fidaxomicin can be increased when it is combined with Citalopram.Approved
ClarithromycinThe serum concentration of Fidaxomicin can be increased when it is combined with Clarithromycin.Approved
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Fidaxomicin.Approved, Illicit
ClofazimineThe serum concentration of Fidaxomicin can be increased when it is combined with Clofazimine.Approved, Investigational
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Fidaxomicin.Approved, Investigational
ClomipramineThe serum concentration of Fidaxomicin can be increased when it is combined with Clomipramine.Approved, Vet Approved
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Fidaxomicin.Approved
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Fidaxomicin.Approved, Nutraceutical
ClotrimazoleThe serum concentration of Fidaxomicin can be decreased when it is combined with Clotrimazole.Approved, Vet Approved
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Fidaxomicin.Approved
CobicistatThe serum concentration of Fidaxomicin can be increased when it is combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Fidaxomicin.Approved
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Fidaxomicin.Approved
ColforsinThe serum concentration of Fidaxomicin can be increased when it is combined with Colforsin.Experimental
Conjugated estrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Fidaxomicin.Approved
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Fidaxomicin.Approved
CyclophosphamideThe serum concentration of Fidaxomicin can be increased when it is combined with Cyclophosphamide.Approved, Investigational
CyclosporineThe serum concentration of Fidaxomicin can be decreased when it is combined with Cyclosporine.Approved, Investigational, Vet Approved
Dabigatran etexilateThe serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Fidaxomicin.Approved
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Fidaxomicin.Approved
DaclatasvirThe serum concentration of Fidaxomicin can be increased when it is combined with Daclatasvir.Approved
DactinomycinThe serum concentration of Fidaxomicin can be increased when it is combined with Dactinomycin.Approved
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Fidaxomicin.Approved
DasatinibThe serum concentration of Fidaxomicin can be increased when it is combined with Dasatinib.Approved, Investigational
DaunorubicinThe serum concentration of Fidaxomicin can be decreased when it is combined with Daunorubicin.Approved
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Fidaxomicin.Approved
DesipramineThe serum concentration of Fidaxomicin can be increased when it is combined with Desipramine.Approved
DesloratadineThe serum concentration of Fidaxomicin can be increased when it is combined with Desloratadine.Approved, Investigational
DexamethasoneThe serum concentration of Fidaxomicin can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DextromethorphanThe serum concentration of Fidaxomicin can be increased when it is combined with Dextromethorphan.Approved
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Fidaxomicin.Approved, Illicit, Vet Approved
DiclofenacThe serum concentration of Fidaxomicin can be increased when it is combined with Diclofenac.Approved, Vet Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Fidaxomicin.Approved
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Fidaxomicin.Approved
DigoxinThe serum concentration of Fidaxomicin can be decreased when it is combined with Digoxin.Approved
DihydroergotamineThe serum concentration of Fidaxomicin can be increased when it is combined with Dihydroergotamine.Approved
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Fidaxomicin.Illicit
DiltiazemThe serum concentration of Fidaxomicin can be increased when it is combined with Diltiazem.Approved
DipyridamoleThe serum concentration of Fidaxomicin can be increased when it is combined with Dipyridamole.Approved
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Fidaxomicin.Approved, Investigational
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Fidaxomicin.Approved, Investigational, Vet Approved
DoxazosinThe serum concentration of Fidaxomicin can be increased when it is combined with Doxazosin.Approved
DoxepinThe serum concentration of Fidaxomicin can be increased when it is combined with Doxepin.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Fidaxomicin.Approved, Investigational
DoxorubicinThe serum concentration of Fidaxomicin can be decreased when it is combined with Doxorubicin.Approved, Investigational
DronabinolThe serum concentration of Fidaxomicin can be increased when it is combined with Dronabinol.Approved, Illicit
DronedaroneThe serum concentration of Fidaxomicin can be increased when it is combined with Dronedarone.Approved
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Fidaxomicin.Approved
ElbasvirThe serum concentration of Fidaxomicin can be increased when it is combined with Elbasvir.Approved
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Fidaxomicin.Approved, Investigational
EnalaprilThe serum concentration of Fidaxomicin can be increased when it is combined with Enalapril.Approved, Vet Approved
EnzalutamideThe serum concentration of Fidaxomicin can be increased when it is combined with Enzalutamide.Approved
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Fidaxomicin.Approved, Investigational
ErgonovineThe serum concentration of Fidaxomicin can be increased when it is combined with Ergonovine.Approved
ErgotamineThe serum concentration of Fidaxomicin can be increased when it is combined with Ergotamine.Approved
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Fidaxomicin.Approved, Investigational
ErythromycinThe serum concentration of Fidaxomicin can be decreased when it is combined with Erythromycin.Approved, Vet Approved
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Fidaxomicin.Approved, Investigational, Vet Approved
EstramustineThe serum concentration of Fidaxomicin can be increased when it is combined with Estramustine.Approved
EstriolThe serum concentration of Fidaxomicin can be decreased when it is combined with Estriol.Approved, Vet Approved
EstroneThe serum concentration of Fidaxomicin can be decreased when it is combined with Estrone.Approved
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Fidaxomicin.Approved
EtoposideThe serum concentration of Fidaxomicin can be increased when it is combined with Etoposide.Approved
EtravirineThe serum concentration of Fidaxomicin can be increased when it is combined with Etravirine.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Fidaxomicin.Approved
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Fidaxomicin.Approved
FelodipineThe serum concentration of Fidaxomicin can be increased when it is combined with Felodipine.Approved, Investigational
FentanylThe serum concentration of Fidaxomicin can be increased when it is combined with Fentanyl.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Fidaxomicin.Approved
FexofenadineThe serum concentration of Fidaxomicin can be increased when it is combined with Fexofenadine.Approved
FluconazoleThe serum concentration of Fidaxomicin can be increased when it is combined with Fluconazole.Approved
FluoxetineThe serum concentration of Fidaxomicin can be increased when it is combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe serum concentration of Fidaxomicin can be increased when it is combined with Flupentixol.Approved, Withdrawn
FluphenazineThe serum concentration of Fidaxomicin can be increased when it is combined with Fluphenazine.Approved
FlurazepamThe serum concentration of Fidaxomicin can be increased when it is combined with Flurazepam.Approved, Illicit
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Fidaxomicin.Approved
FluvoxamineThe serum concentration of Fidaxomicin can be increased when it is combined with Fluvoxamine.Approved, Investigational
GefitinibThe serum concentration of Fidaxomicin can be increased when it is combined with Gefitinib.Approved, Investigational
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Fidaxomicin.Approved
GenisteinThe serum concentration of Fidaxomicin can be increased when it is combined with Genistein.Investigational
GlyburideThe serum concentration of Fidaxomicin can be increased when it is combined with Glyburide.Approved
Gramicidin DThe serum concentration of Fidaxomicin can be increased when it is combined with Gramicidin D.Approved
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Fidaxomicin.Approved
GrepafloxacinThe serum concentration of Fidaxomicin can be increased when it is combined with Grepafloxacin.Withdrawn
HaloperidolThe serum concentration of Fidaxomicin can be increased when it is combined with Haloperidol.Approved
HydrocortisoneThe serum concentration of Fidaxomicin can be increased when it is combined with Hydrocortisone.Approved, Vet Approved
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Fidaxomicin.Approved
IdelalisibThe serum concentration of Idelalisib can be increased when it is combined with Fidaxomicin.Approved
ImatinibThe serum concentration of Fidaxomicin can be increased when it is combined with Imatinib.Approved
ImipramineThe serum concentration of Fidaxomicin can be increased when it is combined with Imipramine.Approved
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Fidaxomicin.Approved
IndinavirThe serum concentration of Fidaxomicin can be decreased when it is combined with Indinavir.Approved
IndomethacinThe serum concentration of Fidaxomicin can be increased when it is combined with Indomethacin.Approved, Investigational
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Fidaxomicin.Approved, Investigational
IsavuconazoniumThe serum concentration of Fidaxomicin can be increased when it is combined with Isavuconazonium.Approved, Investigational
ItraconazoleThe serum concentration of Fidaxomicin can be increased when it is combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Fidaxomicin can be increased when it is combined with Ivacaftor.Approved
IvermectinThe serum concentration of Fidaxomicin can be increased when it is combined with Ivermectin.Approved, Vet Approved
KetamineThe serum concentration of Fidaxomicin can be increased when it is combined with Ketamine.Approved, Vet Approved
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Fidaxomicin.Approved
KetoconazoleThe serum concentration of Fidaxomicin can be increased when it is combined with Ketoconazole.Approved, Investigational
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Fidaxomicin.Approved, Investigational
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Fidaxomicin.Approved, Investigational
LansoprazoleThe serum concentration of Fidaxomicin can be increased when it is combined with Lansoprazole.Approved, Investigational
LapatinibThe serum concentration of Fidaxomicin can be increased when it is combined with Lapatinib.Approved, Investigational
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Fidaxomicin.Approved
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Fidaxomicin.Approved
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Fidaxomicin.Approved
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Fidaxomicin.Approved, Investigational
LevofloxacinThe serum concentration of Fidaxomicin can be increased when it is combined with Levofloxacin.Approved, Investigational
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Fidaxomicin.Approved
LevothyroxineThe serum concentration of Fidaxomicin can be decreased when it is combined with Levothyroxine.Approved
LidocaineThe serum concentration of Fidaxomicin can be increased when it is combined with Lidocaine.Approved, Vet Approved
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Fidaxomicin.Approved
LiothyronineThe serum concentration of Fidaxomicin can be decreased when it is combined with Liothyronine.Approved, Vet Approved
LiotrixThe serum concentration of Fidaxomicin can be decreased when it is combined with Liotrix.Approved
LisinoprilThe serum concentration of Fidaxomicin can be increased when it is combined with Lisinopril.Approved, Investigational
LomitapideThe serum concentration of Fidaxomicin can be increased when it is combined with Lomitapide.Approved
LoperamideThe serum concentration of Fidaxomicin can be increased when it is combined with Loperamide.Approved
LopinavirThe serum concentration of Fidaxomicin can be increased when it is combined with Lopinavir.Approved
LoratadineThe serum concentration of Fidaxomicin can be increased when it is combined with Loratadine.Approved
LosartanThe serum concentration of Fidaxomicin can be increased when it is combined with Losartan.Approved
LovastatinThe serum concentration of Fidaxomicin can be increased when it is combined with Lovastatin.Approved, Investigational
LumacaftorThe serum concentration of Fidaxomicin can be decreased when it is combined with Lumacaftor.Approved
MannitolThe serum concentration of Mannitol can be increased when it is combined with Fidaxomicin.Approved, Investigational
MaprotilineThe serum concentration of Fidaxomicin can be increased when it is combined with Maprotiline.Approved
MebendazoleThe serum concentration of Fidaxomicin can be increased when it is combined with Mebendazole.Approved, Vet Approved
MefloquineThe serum concentration of Fidaxomicin can be increased when it is combined with Mefloquine.Approved
Megestrol acetateThe serum concentration of Fidaxomicin can be increased when it is combined with Megestrol acetate.Approved, Vet Approved
MeprobamateThe serum concentration of Fidaxomicin can be increased when it is combined with Meprobamate.Approved, Illicit
MethadoneThe serum concentration of Fidaxomicin can be increased when it is combined with Methadone.Approved
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Fidaxomicin.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Fidaxomicin.Approved, Vet Approved
MetoprololThe serum concentration of Fidaxomicin can be increased when it is combined with Metoprolol.Approved, Investigational
MibefradilThe serum concentration of Fidaxomicin can be increased when it is combined with Mibefradil.Withdrawn
MiconazoleThe serum concentration of Fidaxomicin can be increased when it is combined with Miconazole.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Fidaxomicin can be decreased when it is combined with Midazolam.Approved, Illicit
MifepristoneThe serum concentration of Fidaxomicin can be decreased when it is combined with Mifepristone.Approved, Investigational
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Fidaxomicin.Approved
MitomycinThe serum concentration of Fidaxomicin can be increased when it is combined with Mitomycin.Approved
MitoxantroneThe serum concentration of Fidaxomicin can be decreased when it is combined with Mitoxantrone.Approved, Investigational
MorphineThe serum concentration of Fidaxomicin can be increased when it is combined with Morphine.Approved, Investigational
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Fidaxomicin.Approved, Investigational
NadololThe serum concentration of Nadolol can be increased when it is combined with Fidaxomicin.Approved
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Fidaxomicin.Approved
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Fidaxomicin.Approved, Vet Approved
NaltrexoneThe serum concentration of Fidaxomicin can be increased when it is combined with Naltrexone.Approved, Investigational, Vet Approved
NaringeninThe serum concentration of Fidaxomicin can be increased when it is combined with Naringenin.Experimental
NefazodoneThe serum concentration of Fidaxomicin can be decreased when it is combined with Nefazodone.Approved, Withdrawn
NelfinavirThe serum concentration of Fidaxomicin can be decreased when it is combined with Nelfinavir.Approved
NeostigmineThe serum concentration of Fidaxomicin can be increased when it is combined with Neostigmine.Approved, Vet Approved
NicardipineThe serum concentration of Fidaxomicin can be increased when it is combined with Nicardipine.Approved
NifedipineThe serum concentration of Fidaxomicin can be decreased when it is combined with Nifedipine.Approved
NilotinibThe serum concentration of Fidaxomicin can be increased when it is combined with Nilotinib.Approved, Investigational
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Fidaxomicin.Approved
NisoldipineThe serum concentration of Fidaxomicin can be increased when it is combined with Nisoldipine.Approved
NitrazepamThe serum concentration of Fidaxomicin can be increased when it is combined with Nitrazepam.Approved
NitrendipineThe serum concentration of Fidaxomicin can be increased when it is combined with Nitrendipine.Approved
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Fidaxomicin.Approved
NorethisteroneThe serum concentration of Fidaxomicin can be decreased when it is combined with Norethisterone.Approved
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Fidaxomicin.Approved, Investigational
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Fidaxomicin.Approved
OmeprazoleThe serum concentration of Fidaxomicin can be increased when it is combined with Omeprazole.Approved, Investigational, Vet Approved
OsimertinibThe serum concentration of Osimertinib can be increased when it is combined with Fidaxomicin.Approved
P-NitrophenolThe serum concentration of Fidaxomicin can be increased when it is combined with P-Nitrophenol.Experimental
PaclitaxelThe serum concentration of Fidaxomicin can be increased when it is combined with Paclitaxel.Approved, Vet Approved
Palmitic AcidThe serum concentration of Fidaxomicin can be increased when it is combined with Palmitic Acid.Experimental
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Fidaxomicin.Approved, Investigational
PantoprazoleThe serum concentration of Fidaxomicin can be increased when it is combined with Pantoprazole.Approved
ParoxetineThe serum concentration of Fidaxomicin can be increased when it is combined with Paroxetine.Approved, Investigational
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Fidaxomicin.Approved
PerindoprilThe serum concentration of Fidaxomicin can be increased when it is combined with Perindopril.Approved
PhenobarbitalThe serum concentration of Fidaxomicin can be decreased when it is combined with Phenobarbital.Approved
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Fidaxomicin.Approved, Vet Approved
Picosulfuric acidThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Fidaxomicin.Approved
PimozideThe serum concentration of Fidaxomicin can be increased when it is combined with Pimozide.Approved
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Fidaxomicin.Approved
Platelet Activating FactorThe serum concentration of Fidaxomicin can be decreased when it is combined with Platelet Activating Factor.Experimental
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Fidaxomicin.Approved
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Fidaxomicin.Approved
PosaconazoleThe serum concentration of Fidaxomicin can be increased when it is combined with Posaconazole.Approved, Investigational, Vet Approved
PravastatinThe serum concentration of Fidaxomicin can be increased when it is combined with Pravastatin.Approved
PrazosinThe serum concentration of Fidaxomicin can be increased when it is combined with Prazosin.Approved
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Fidaxomicin.Approved, Vet Approved
PrednisoneThe serum concentration of Fidaxomicin can be increased when it is combined with Prednisone.Approved, Vet Approved
ProbenecidThe serum concentration of Fidaxomicin can be increased when it is combined with Probenecid.Approved
ProgesteroneThe serum concentration of Fidaxomicin can be decreased when it is combined with Progesterone.Approved, Vet Approved
PromethazineThe serum concentration of Fidaxomicin can be increased when it is combined with Promethazine.Approved
PropafenoneThe serum concentration of Fidaxomicin can be increased when it is combined with Propafenone.Approved
PropranololThe serum concentration of Fidaxomicin can be increased when it is combined with Propranolol.Approved, Investigational
ProtriptylineThe serum concentration of Fidaxomicin can be increased when it is combined with Protriptyline.Approved
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Fidaxomicin.Approved
QuercetinThe serum concentration of Fidaxomicin can be increased when it is combined with Quercetin.Experimental
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Fidaxomicin.Approved
QuinacrineThe serum concentration of Fidaxomicin can be increased when it is combined with Quinacrine.Approved
QuinidineThe serum concentration of Fidaxomicin can be increased when it is combined with Quinidine.Approved
QuinineThe serum concentration of Fidaxomicin can be increased when it is combined with Quinine.Approved
RanitidineThe serum concentration of Fidaxomicin can be increased when it is combined with Ranitidine.Approved
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Fidaxomicin.Approved, Investigational
ReboxetineThe serum concentration of Fidaxomicin can be increased when it is combined with Reboxetine.Approved, Investigational
RegorafenibThe serum concentration of Fidaxomicin can be increased when it is combined with Regorafenib.Approved
ReserpineThe serum concentration of Fidaxomicin can be decreased when it is combined with Reserpine.Approved
RifampicinThe serum concentration of Fidaxomicin can be decreased when it is combined with Rifampicin.Approved
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Fidaxomicin.Approved, Investigational
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Fidaxomicin.Approved
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Fidaxomicin.Approved, Investigational
RitonavirThe serum concentration of Fidaxomicin can be decreased when it is combined with Ritonavir.Approved, Investigational
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Fidaxomicin.Approved
RolapitantThe serum concentration of Fidaxomicin can be increased when it is combined with Rolapitant.Approved
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Fidaxomicin.Approved, Investigational
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Fidaxomicin.Approved, Vet Approved
SaquinavirThe serum concentration of Fidaxomicin can be decreased when it is combined with Saquinavir.Approved, Investigational
ScopolamineThe serum concentration of Fidaxomicin can be increased when it is combined with Scopolamine.Approved
SelegilineThe serum concentration of Fidaxomicin can be increased when it is combined with Selegiline.Approved, Investigational, Vet Approved
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Fidaxomicin.Approved
SertralineThe serum concentration of Fidaxomicin can be increased when it is combined with Sertraline.Approved
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Fidaxomicin.Approved
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Fidaxomicin.Approved
SimvastatinThe serum concentration of Fidaxomicin can be increased when it is combined with Simvastatin.Approved
SirolimusThe serum concentration of Fidaxomicin can be decreased when it is combined with Sirolimus.Approved, Investigational
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Fidaxomicin.Approved, Investigational
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Fidaxomicin.Approved
SorafenibThe serum concentration of Fidaxomicin can be increased when it is combined with Sorafenib.Approved, Investigational
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Fidaxomicin.Approved
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Fidaxomicin.Experimental
SpironolactoneThe serum concentration of Fidaxomicin can be increased when it is combined with Spironolactone.Approved
St. John's WortThe serum concentration of Fidaxomicin can be decreased when it is combined with St. John&#39;s Wort.Nutraceutical
StaurosporineThe serum concentration of Fidaxomicin can be increased when it is combined with Staurosporine.Experimental
StreptozocinThe serum concentration of Fidaxomicin can be decreased when it is combined with Streptozocin.Approved
SulfinpyrazoneThe serum concentration of Fidaxomicin can be increased when it is combined with Sulfinpyrazone.Approved
SumatriptanThe serum concentration of Fidaxomicin can be increased when it is combined with Sumatriptan.Approved, Investigational
SunitinibThe serum concentration of Fidaxomicin can be increased when it is combined with Sunitinib.Approved, Investigational
TacrineThe serum concentration of Fidaxomicin can be increased when it is combined with Tacrine.Withdrawn
TacrolimusThe serum concentration of Fidaxomicin can be decreased when it is combined with Tacrolimus.Approved, Investigational
TamoxifenThe serum concentration of Fidaxomicin can be decreased when it is combined with Tamoxifen.Approved
Taurocholic AcidThe serum concentration of Fidaxomicin can be increased when it is combined with Taurocholic Acid.Experimental
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Fidaxomicin.Approved
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Fidaxomicin.Withdrawn
TelmisartanThe serum concentration of Fidaxomicin can be increased when it is combined with Telmisartan.Approved, Investigational
TemsirolimusThe serum concentration of Fidaxomicin can be increased when it is combined with Temsirolimus.Approved
TerazosinThe serum concentration of Fidaxomicin can be increased when it is combined with Terazosin.Approved
TerfenadineFidaxomicin may increase the QTc-prolonging activities of Terfenadine.Withdrawn
TesmilifeneThe serum concentration of Fidaxomicin can be decreased when it is combined with Tesmilifene.Investigational
TestosteroneThe serum concentration of Fidaxomicin can be increased when it is combined with Testosterone.Approved, Investigational
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Fidaxomicin.Approved
TimololThe serum concentration of Timolol can be increased when it is combined with Fidaxomicin.Approved
TolvaptanThe serum concentration of Fidaxomicin can be increased when it is combined with Tolvaptan.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Fidaxomicin.Approved, Investigational
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Fidaxomicin.Approved, Investigational
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Fidaxomicin.Approved
TrazodoneThe serum concentration of Fidaxomicin can be decreased when it is combined with Trazodone.Approved, Investigational
TrifluoperazineThe serum concentration of Fidaxomicin can be increased when it is combined with Trifluoperazine.Approved
TriflupromazineThe serum concentration of Fidaxomicin can be increased when it is combined with Triflupromazine.Approved, Vet Approved
TrimethoprimThe serum concentration of Fidaxomicin can be decreased when it is combined with Trimethoprim.Approved, Vet Approved
TrimipramineThe serum concentration of Fidaxomicin can be increased when it is combined with Trimipramine.Approved
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Fidaxomicin.Approved
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Fidaxomicin.Approved
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Fidaxomicin.Approved
VenetoclaxThe serum concentration of Venetoclax can be increased when it is combined with Fidaxomicin.Approved
VenlafaxineThe serum concentration of Fidaxomicin can be increased when it is combined with Venlafaxine.Approved
VerapamilThe serum concentration of Fidaxomicin can be decreased when it is combined with Verapamil.Approved
VinblastineThe serum concentration of Fidaxomicin can be decreased when it is combined with Vinblastine.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Fidaxomicin.Approved, Investigational
VincristineThe serum concentration of Fidaxomicin can be decreased when it is combined with Vincristine.Approved, Investigational
VinorelbineThe serum concentration of Fidaxomicin can be increased when it is combined with Vinorelbine.Approved, Investigational
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Fidaxomicin.Approved
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Fidaxomicin.Approved
ZimelidineThe serum concentration of Fidaxomicin can be increased when it is combined with Zimelidine.Withdrawn
Food Interactions
  • Food decreases Cmax of fidaxomicin and its metabolites however this is not considered clinically significant.
References
Synthesis Reference

Youe-Kong Shue, Chi-Jen Frank Du, Ming-Hsi Chiou, Mei-Chiao Wu, Yuan-Ting Chen, Franklin W. Okumu, Jonathan James Duffield, "Medium for the Production of Tiacumicin B." U.S. Patent US20100028970, issued February 04, 2010.

US20100028970
General References
  1. Artsimovitch I, Seddon J, Sears P: Fidaxomicin is an inhibitor of the initiation of bacterial RNA synthesis. Clin Infect Dis. 2012 Aug;55 Suppl 2:S127-31. doi: 10.1093/cid/cis358. [PubMed:22752861 ]
  2. Crawford T, Huesgen E, Danziger L: Fidaxomicin: a novel macrocyclic antibiotic for the treatment of Clostridium difficile infection. Am J Health Syst Pharm. 2012 Jun 1;69(11):933-43. doi: 10.2146/ajhp110371. [PubMed:22610025 ]
External Links
ATC CodesA07AA12 — Fidaxomicin
AHFS Codes
  • 8:12.12.92
PDB EntriesNot Available
FDA labelDownload (207 KB)
MSDSDownload (143 KB)
Clinical Trials
Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedNot AvailableHealthy Volunteers / Pharmacokinetics of Fidaxomicin1
1CompletedBasic ScienceDrug-Drug Interaction (DDI) / Healthy Volunteers / Intestinal Absorption / Pharmacokinetics of Fidaxomicin / Pharmacokinetics of Rosuvastatin1
2Active Not RecruitingTreatmentClostridium Difficile Infection (CDI)1
2CompletedTreatmentClostridium Difficile-Associated Diarrhea (CDAD)1
2CompletedTreatmentDiarrhea1
3CompletedPreventionClostridium Difficile-Associated Diarrhea (CDAD)1
3CompletedTreatmentClostridium Difficile1
3CompletedTreatmentClostridium Infections / Diarrhea2
3RecruitingTreatmentClostridium Difficile Infection (CDI)2
3RecruitingTreatmentClostridium Difficile-Associated Diarrhea (CDAD)1
4CompletedTreatmentClostridium Difficile1
4CompletedTreatmentClostridium Difficile Infection (CDI) / Inflammatory Bowel Diseases (IBD)1
4Not Yet RecruitingTreatmentClostridium Difficile Infection (CDI)1
4Not Yet RecruitingTreatmentClostridium Difficile Infection (CDI) / Solid Organ Transplant1
4RecruitingTreatmentClostridium / Difficile / Fidaxomicin / Vancomycin1
4TerminatedTreatmentClostridium Difficile1
4TerminatedTreatmentClostridium Difficile / Spinal Cord Injuries (SCI)1
4Unknown StatusTreatmentClostridium Difficile Infection (CDI)1
4WithdrawnPreventionClostridium Difficile Infection (CDI)1
Not AvailableActive Not RecruitingNot AvailableClostridium Difficile Infection (CDI)1
Not AvailableRecruitingNot AvailableC. Difficile / Diarrhea / Enterocolitis1
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
TabletOral200 mg
Tablet, film coatedOral200 mg/1
Tablet, film coatedOral200 mg
PricesNot Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US8859510 No2007-07-312027-07-31Us
US7906489 No2007-03-042027-03-04Us
US7378508 No2007-07-312027-07-31Us
US7863249 No2007-07-312027-07-31Us
US8586551 No2004-04-122024-04-12Us
Properties
StateSolid
Experimental PropertiesNot Available
Predicted Properties
PropertyValueSource
Water Solubility0.0125 mg/mLALOGPS
logP5.59ALOGPS
logP8.56ChemAxon
logS-4.9ALOGPS
pKa (Strongest Acidic)5.87ChemAxon
pKa (Strongest Basic)-1.4ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count15ChemAxon
Hydrogen Donor Count7ChemAxon
Polar Surface Area266.66 Å2ChemAxon
Rotatable Bond Count15ChemAxon
Refractivity269.66 m3·mol-1ChemAxon
Polarizability110.47 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption-0.6628
Blood Brain Barrier-0.8559
Caco-2 permeable-0.6641
P-glycoprotein substrateSubstrate0.8975
P-glycoprotein inhibitor INon-inhibitor0.5357
P-glycoprotein inhibitor IINon-inhibitor0.902
Renal organic cation transporterNon-inhibitor0.9112
CYP450 2C9 substrateNon-substrate0.8485
CYP450 2D6 substrateNon-substrate0.8756
CYP450 3A4 substrateSubstrate0.6796
CYP450 1A2 substrateNon-inhibitor0.7059
CYP450 2C9 inhibitorNon-inhibitor0.6775
CYP450 2D6 inhibitorNon-inhibitor0.8859
CYP450 2C19 inhibitorNon-inhibitor0.6826
CYP450 3A4 inhibitorNon-inhibitor0.899
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7301
Ames testNon AMES toxic0.7118
CarcinogenicityNon-carcinogens0.928
BiodegradationNot ready biodegradable0.9721
Rat acute toxicity2.6789 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9875
hERG inhibition (predictor II)Non-inhibitor0.7335
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of chemical entities known as macrolides and analogues. These are organic compounds containing a lactone ring of at least twelve members.
KingdomChemical entities
Super ClassOrganic compounds
ClassPhenylpropanoids and polyketides
Sub ClassMacrolides and analogues
Direct ParentMacrolides and analogues
Alternative Parentsp-Hydroxybenzoic acid alkyl esters / o-Hydroxybenzoic acid esters / O-glycosyl compounds / 3-halobenzoic acids and derivatives / Salicylic acid and derivatives / Tricarboxylic acids and derivatives / Benzoyl derivatives / Dichlorobenzenes / O-chlorophenols / P-chlorophenols
SubstituentsMacrolide / P-hydroxybenzoic acid alkyl ester / P-hydroxybenzoic acid ester / O-hydroxybenzoic acid ester / Glycosyl compound / Dihydroxybenzoic acid / O-glycosyl compound / Benzoate ester / Salicylic acid or derivatives / 3-halobenzoic acid or derivatives
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptorscarboxylic ester, organochlorine compound, phenols, macrolide antibiotic, glycoside (CHEBI:68590 )

Targets

Kind
Protein
Organism
Clostridium difficile (strain 630)
Pharmacological action
yes
Actions
inhibitor
General Function:
Transcription factor activity, sequence-specific dna binding
Specific Function:
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
Gene Name:
sigA1
Uniprot ID:
Q18BX5
Uniprot Name:
RNA polymerase sigma factor SigA
Molecular Weight:
44426.185 Da
References
  1. Venugopal AA, Johnson S: Fidaxomicin: a novel macrocyclic antibiotic approved for treatment of Clostridium difficile infection. Clin Infect Dis. 2012 Feb 15;54(4):568-74. doi: 10.1093/cid/cir830. Epub 2011 Dec 7. [PubMed:22156854 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Uniprot Name:
Multidrug resistance protein 1
Molecular Weight:
141477.255 Da
References
  1. Crawford T, Huesgen E, Danziger L: Fidaxomicin: a novel macrocyclic antibiotic for the treatment of Clostridium difficile infection. Am J Health Syst Pharm. 2012 Jun 1;69(11):933-43. doi: 10.2146/ajhp110371. [PubMed:22610025 ]
Drug created on May 12, 2013 16:32 / Updated on September 01, 2017 11:59