Barnidipine

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Barnidipine
Accession Number
DB09227
Type
Small Molecule
Groups
Approved
Description

Bamidipine is an antihypertensive drug belonging to the dihydropyridine (DHP) group of calcium antagonists. It is available in a modified-release formulation which has a gradual onset of action and is effective in a single daily oral dose of 10 to 20 mg. Bamidipine has selective action against cardiovascular calcium antagonist receptors and its antihypertensive action is related to the reduction of peripheral vascular resistance secondary to its vasodilatory action. The clinical antihypertensive efficacy of barnidipine is similar to that of other DHP calcium antagonists such as nitrendipine and amlodipine, and antihypertensives belonging to other drug classes such as atenolol and enalapril. Barnidipine has been found to be as efficacious and well tolerated as hydrochlorothiazide in the management of hypertension in elderly patients. Barnidipine is generally well tolerated. As with other DHP calcium antagonists, vasodilator adverse events such as headache, flushing and peripheral oedema account for most of the adverse events reported with its use and are usually transient. Oedema is less frequent than with amlodipine and nitrendipine. Its use is not associated with reflex tachycardia. [PMID: 11434453]

Structure
Thumb
Synonyms
  • Mepirodipine
Categories
UNII
2VBY96ASWJ
CAS number
104713-75-9
Weight
Average: 491.544
Monoisotopic: 491.205635666
Chemical Formula
C27H29N3O6
InChI Key
VXMOONUMYLCFJD-DHLKQENFSA-N
InChI
InChI=1S/C27H29N3O6/c1-17-23(26(31)35-3)25(20-10-7-11-21(14-20)30(33)34)24(18(2)28-17)27(32)36-22-12-13-29(16-22)15-19-8-5-4-6-9-19/h4-11,14,22,25,28H,12-13,15-16H2,1-3H3/t22-,25-/m0/s1
IUPAC Name
3-(3S)-1-benzylpyrrolidin-3-yl 5-methyl (4S)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
SMILES
COC(=O)C1=C(C)NC(C)=C([[email protected]]1C1=CC(=CC=C1)[N+]([O-])=O)C(=O)O[[email protected]]1CCN(CC2=CC=CC=C2)C1

Pharmacology

Indication

For the treatment of hypertension and chronic stable angina.

Structured Indications
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
2-HYDROXY-1,4-NAPHTHOQUINONEThe risk or severity of adverse effects can be increased when 2-HYDROXY-1,4-NAPHTHOQUINONE is combined with Barnidipine.Experimental
2-mercaptobenzothiazoleThe risk or severity of adverse effects can be increased when 2-mercaptobenzothiazole is combined with Barnidipine.Vet Approved
AcebutololThe risk or severity of adverse effects can be increased when Barnidipine is combined with Acebutolol.Approved
AldesleukinThe risk or severity of adverse effects can be increased when Barnidipine is combined with Aldesleukin.Approved
AlfuzosinAlfuzosin may increase the hypotensive activities of Barnidipine.Approved, Investigational
AliskirenThe risk or severity of adverse effects can be increased when Barnidipine is combined with Aliskiren.Approved, Investigational
AmifostineThe risk or severity of adverse effects can be increased when Amifostine is combined with Barnidipine.Approved, Investigational
AmilorideThe risk or severity of adverse effects can be increased when Barnidipine is combined with Amiloride.Approved
AmiodaroneThe serum concentration of Barnidipine can be increased when it is combined with Amiodarone.Approved, Investigational
AmlodipineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Amlodipine.Approved
AmobarbitalThe metabolism of Barnidipine can be increased when combined with Amobarbital.Approved, Illicit
AmorolfineThe risk or severity of adverse effects can be increased when Amorolfine is combined with Barnidipine.Approved, Investigational
Amphotericin BThe risk or severity of adverse effects can be increased when Amphotericin B is combined with Barnidipine.Approved, Investigational
Amyl NitriteThe risk or severity of adverse effects can be increased when Barnidipine is combined with Amyl Nitrite.Approved
AnidulafunginThe risk or severity of adverse effects can be increased when Anidulafungin is combined with Barnidipine.Approved, Investigational
ApomorphineThe risk or severity of adverse effects can be increased when Apomorphine is combined with Barnidipine.Approved, Investigational
ApraclonidineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Apraclonidine.Approved
AripiprazoleAripiprazole may increase the hypotensive activities of Barnidipine.Approved, Investigational
ArotinololThe risk or severity of adverse effects can be increased when Arotinolol is combined with Barnidipine.Approved, Investigational
Arsenic trioxideThe risk or severity of adverse effects can be increased when Arsenic trioxide is combined with Barnidipine.Approved, Investigational
ArtemetherThe risk or severity of adverse effects can be increased when Artemether is combined with Barnidipine.Approved
AtazanavirThe serum concentration of Barnidipine can be increased when it is combined with Atazanavir.Approved, Investigational
AtenololThe risk or severity of adverse effects can be increased when Barnidipine is combined with Atenolol.Approved
AtorvastatinThe risk or severity of adverse effects can be increased when Barnidipine is combined with Atorvastatin.Approved
AtosibanThe risk or severity of adverse effects can be increased when Barnidipine is combined with Atosiban.Approved, Investigational
Atracurium besylateBarnidipine may increase the neuromuscular blocking activities of Atracurium besylate.Approved
Azilsartan medoxomilThe risk or severity of adverse effects can be increased when Barnidipine is combined with Azilsartan medoxomil.Approved
Bafilomycin A1The risk or severity of adverse effects can be increased when Bafilomycin A1 is combined with Barnidipine.Experimental
BarbexacloneBarbexaclone may increase the hypotensive activities of Barnidipine.Experimental
BarbitalThe metabolism of Barnidipine can be increased when combined with Barbital.Illicit
BenazeprilThe risk or severity of adverse effects can be increased when Barnidipine is combined with Benazepril.Approved, Investigational
BendroflumethiazideThe risk or severity of adverse effects can be increased when Barnidipine is combined with Bendroflumethiazide.Approved
Benzoic AcidThe risk or severity of adverse effects can be increased when Benzoic Acid is combined with Barnidipine.Approved
BepridilThe risk or severity of adverse effects can be increased when Barnidipine is combined with Bepridil.Approved, Withdrawn
BetaxololThe risk or severity of adverse effects can be increased when Barnidipine is combined with Betaxolol.Approved
BifonazoleThe risk or severity of adverse effects can be increased when Bifonazole is combined with Barnidipine.Approved, Investigational
BisoprololThe risk or severity of adverse effects can be increased when Barnidipine is combined with Bisoprolol.Approved
BoceprevirThe serum concentration of Barnidipine can be increased when it is combined with Boceprevir.Approved, Withdrawn
BortezomibThe risk or severity of adverse effects can be increased when Barnidipine is combined with Bortezomib.Approved, Investigational
Brefeldin AThe risk or severity of adverse effects can be increased when Brefeldin A is combined with Barnidipine.Experimental
BretyliumThe risk or severity of adverse effects can be increased when Barnidipine is combined with Bretylium.Approved
BrimonidineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Brimonidine.Approved
BromocriptineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Bromocriptine.Approved, Investigational
BucindololBucindolol may increase the hypotensive activities of Barnidipine.Investigational
BumetanideThe risk or severity of adverse effects can be increased when Barnidipine is combined with Bumetanide.Approved
BunazosinBunazosin may increase the hypotensive activities of Barnidipine.Investigational
BupivacaineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Bupivacaine.Approved, Investigational
ButenafineThe risk or severity of adverse effects can be increased when Butenafine is combined with Barnidipine.Approved
ButoconazoleThe risk or severity of adverse effects can be increased when Butoconazole is combined with Barnidipine.Approved
Calcium AcetateThe therapeutic efficacy of Barnidipine can be decreased when used in combination with Calcium Acetate.Approved
Calcium CarbonateThe therapeutic efficacy of Barnidipine can be decreased when used in combination with Calcium Carbonate.Approved
Calcium ChlorideThe therapeutic efficacy of Barnidipine can be decreased when used in combination with Calcium Chloride.Approved
Calcium CitrateThe therapeutic efficacy of Barnidipine can be decreased when used in combination with Calcium Citrate.Approved
Calcium glubionateThe therapeutic efficacy of Barnidipine can be decreased when used in combination with Calcium glubionate.Approved
Calcium GluceptateThe therapeutic efficacy of Barnidipine can be decreased when used in combination with Calcium Gluceptate.Approved
Calcium gluconateThe therapeutic efficacy of Barnidipine can be decreased when used in combination with Calcium gluconate.Approved, Vet Approved
Calcium lactateThe therapeutic efficacy of Barnidipine can be decreased when used in combination with Calcium lactate.Approved, Experimental, Investigational, Vet Approved
Calcium lactate gluconateThe therapeutic efficacy of Barnidipine can be decreased when used in combination with Calcium lactate gluconate.Experimental
Calcium laevulateThe therapeutic efficacy of Barnidipine can be decreased when used in combination with Calcium laevulate.Experimental
Calcium pangamateThe therapeutic efficacy of Barnidipine can be decreased when used in combination with Calcium pangamate.Experimental
Calcium PhosphateThe therapeutic efficacy of Barnidipine can be decreased when used in combination with Calcium Phosphate.Approved
CanagliflozinThe risk or severity of adverse effects can be increased when Barnidipine is combined with Canagliflozin.Approved
Candesartan cilexetilThe risk or severity of adverse effects can be increased when Barnidipine is combined with Candesartan cilexetil.Approved
CandicidinThe risk or severity of adverse effects can be increased when Candicidin is combined with Barnidipine.Withdrawn
Capric acidThe risk or severity of adverse effects can be increased when Capric acid is combined with Barnidipine.Experimental
CaptoprilThe risk or severity of adverse effects can be increased when Barnidipine is combined with Captopril.Approved
CarbetocinThe risk or severity of adverse effects can be increased when Barnidipine is combined with Carbetocin.Approved
CarbomycinThe metabolism of Barnidipine can be decreased when combined with Carbomycin.Vet Approved
CarteololThe risk or severity of adverse effects can be increased when Barnidipine is combined with Carteolol.Approved
CarvedilolCarvedilol may increase the hypotensive activities of Barnidipine.Approved, Investigational
CaseinThe therapeutic efficacy of Barnidipine can be decreased when used in combination with Casein.Approved
CaspofunginThe risk or severity of adverse effects can be increased when Caspofungin is combined with Barnidipine.Approved
CeritinibThe serum concentration of Barnidipine can be increased when it is combined with Ceritinib.Approved
CerivastatinThe risk or severity of adverse effects can be increased when Barnidipine is combined with Cerivastatin.Withdrawn
CeruleninThe risk or severity of adverse effects can be increased when Cerulenin is combined with Barnidipine.Approved
ChlorothiazideThe risk or severity of adverse effects can be increased when Barnidipine is combined with Chlorothiazide.Approved, Vet Approved
ChloroxineThe risk or severity of adverse effects can be increased when Chloroxine is combined with Barnidipine.Approved
ChlorpromazineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Chlorpromazine.Approved, Vet Approved
ChlorthalidoneThe risk or severity of adverse effects can be increased when Barnidipine is combined with Chlorthalidone.Approved
CiclopiroxThe risk or severity of adverse effects can be increased when Ciclopirox is combined with Barnidipine.Approved, Investigational
CilazaprilThe risk or severity of adverse effects can be increased when Barnidipine is combined with Cilazapril.Approved
CilnidipineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Cilnidipine.Approved, Investigational
CimetidineThe serum concentration of Barnidipine can be increased when it is combined with Cimetidine.Approved
ClarithromycinThe serum concentration of Barnidipine can be increased when it is combined with Clarithromycin.Approved
ClevidipineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Clevidipine.Approved
ClofarabineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Clofarabine.Approved, Investigational
ClomipramineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Clomipramine.Approved, Vet Approved
ClonidineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Clonidine.Approved
ClopidogrelThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Barnidipine.Approved, Nutraceutical
ClotrimazoleThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Barnidipine.Approved, Vet Approved
ClozapineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Clozapine.Approved
CobicistatThe serum concentration of Barnidipine can be increased when it is combined with Cobicistat.Approved
ConivaptanThe risk or severity of adverse effects can be increased when Barnidipine is combined with Conivaptan.Approved, Investigational
CordycepinThe risk or severity of adverse effects can be increased when Cordycepin is combined with Barnidipine.Investigational
CyclosporineThe risk or severity of adverse effects can be increased when Cyclosporine is combined with Barnidipine.Approved, Investigational, Vet Approved
DapagliflozinThe risk or severity of adverse effects can be increased when Barnidipine is combined with Dapagliflozin.Approved
DapoxetineDapoxetine may increase the orthostatic hypotensive activities of Barnidipine.Investigational
DarunavirThe serum concentration of Barnidipine can be increased when it is combined with Darunavir.Approved
DesfluraneThe risk or severity of adverse effects can be increased when Barnidipine is combined with Desflurane.Approved
DexmedetomidineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Dexmedetomidine.Approved, Vet Approved
DichloropheneThe risk or severity of adverse effects can be increased when Dichlorophene is combined with Barnidipine.Vet Approved
DiclofenamideThe risk or severity of adverse effects can be increased when Barnidipine is combined with Diclofenamide.Approved
DigoxinThe risk or severity of adverse effects can be increased when Barnidipine is combined with Digoxin.Approved
DiltiazemThe risk or severity of adverse effects can be increased when Barnidipine is combined with Diltiazem.Approved
DinutuximabThe risk or severity of adverse effects can be increased when Barnidipine is combined with Dinutuximab.Approved
DipyridamoleThe risk or severity of adverse effects can be increased when Barnidipine is combined with Dipyridamole.Approved
DoxazosinDoxazosin may increase the hypotensive activities of Barnidipine.Approved
DuloxetineBarnidipine may increase the orthostatic hypotensive activities of Duloxetine.Approved
EconazoleThe risk or severity of adverse effects can be increased when Econazole is combined with Barnidipine.Approved
EfavirenzThe serum concentration of Barnidipine can be decreased when it is combined with Efavirenz.Approved, Investigational
EfinaconazoleThe risk or severity of adverse effects can be increased when Efinaconazole is combined with Barnidipine.Approved
EfonidipineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Efonidipine.Approved, Investigational
EmpagliflozinThe risk or severity of adverse effects can be increased when Barnidipine is combined with Empagliflozin.Approved
EnalaprilThe risk or severity of adverse effects can be increased when Barnidipine is combined with Enalapril.Approved, Vet Approved
EnalaprilatThe risk or severity of adverse effects can be increased when Barnidipine is combined with Enalaprilat.Approved
EplerenoneThe risk or severity of adverse effects can be increased when Barnidipine is combined with Eplerenone.Approved
EpoprostenolThe risk or severity of adverse effects can be increased when Barnidipine is combined with Epoprostenol.Approved
EprosartanThe risk or severity of adverse effects can be increased when Barnidipine is combined with Eprosartan.Approved
ErythromycinThe serum concentration of Barnidipine can be increased when it is combined with Erythromycin.Approved, Vet Approved
EsmololThe risk or severity of adverse effects can be increased when Barnidipine is combined with Esmolol.Approved
Etacrynic acidThe risk or severity of adverse effects can be increased when Barnidipine is combined with Etacrynic acid.Approved
FelodipineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Felodipine.Approved, Investigational
FenoldopamThe risk or severity of adverse effects can be increased when Barnidipine is combined with Fenoldopam.Approved
FenticonazoleThe risk or severity of adverse effects can be increased when Fenticonazole is combined with Barnidipine.Experimental
FimasartanThe risk or severity of adverse effects can be increased when Barnidipine is combined with Fimasartan.Approved, Investigational
FluconazoleThe serum concentration of Barnidipine can be increased when it is combined with Fluconazole.Approved
FlucytosineThe risk or severity of adverse effects can be increased when Flucytosine is combined with Barnidipine.Approved
FlutrimazoleThe risk or severity of adverse effects can be increased when Flutrimazole is combined with Barnidipine.Experimental
FluvastatinThe risk or severity of adverse effects can be increased when Barnidipine is combined with Fluvastatin.Approved
FosinoprilThe risk or severity of adverse effects can be increased when Barnidipine is combined with Fosinopril.Approved
FosphenytoinThe serum concentration of Fosphenytoin can be increased when it is combined with Barnidipine.Approved
FurosemideThe risk or severity of adverse effects can be increased when Barnidipine is combined with Furosemide.Approved, Vet Approved
GlyphosateThe risk or severity of adverse effects can be increased when Glyphosate is combined with Barnidipine.Experimental
GriseofulvinThe risk or severity of adverse effects can be increased when Griseofulvin is combined with Barnidipine.Approved, Vet Approved
GuanfacineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Guanfacine.Approved, Investigational
HachimycinThe risk or severity of adverse effects can be increased when Hachimycin is combined with Barnidipine.Experimental
HaloproginThe risk or severity of adverse effects can be increased when Haloprogin is combined with Barnidipine.Approved, Withdrawn
HalothaneThe risk or severity of adverse effects can be increased when Barnidipine is combined with Halothane.Approved, Vet Approved
HexetidineThe risk or severity of adverse effects can be increased when Hexetidine is combined with Barnidipine.Approved, Investigational
HexobarbitalThe metabolism of Barnidipine can be increased when combined with Hexobarbital.Approved
HydralazineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Hydralazine.Approved
HydrochlorothiazideThe risk or severity of adverse effects can be increased when Barnidipine is combined with Hydrochlorothiazide.Approved, Vet Approved
HydroflumethiazideThe risk or severity of adverse effects can be increased when Barnidipine is combined with Hydroflumethiazide.Approved, Investigational
IdelalisibThe serum concentration of Barnidipine can be increased when it is combined with Idelalisib.Approved
IloprostThe risk or severity of adverse effects can be increased when Barnidipine is combined with Iloprost.Approved, Investigational
ImidaprilThe risk or severity of adverse effects can be increased when Barnidipine is combined with Imidapril.Investigational
ImipramineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Imipramine.Approved
IndapamideThe risk or severity of adverse effects can be increased when Barnidipine is combined with Indapamide.Approved
IndinavirThe serum concentration of Barnidipine can be increased when it is combined with Indinavir.Approved
IndoraminIndoramin may increase the hypotensive activities of Barnidipine.Withdrawn
IrbesartanThe risk or severity of adverse effects can be increased when Barnidipine is combined with Irbesartan.Approved, Investigational
IsocarboxazidThe risk or severity of adverse effects can be increased when Barnidipine is combined with Isocarboxazid.Approved
IsoconazoleThe risk or severity of adverse effects can be increased when Isoconazole is combined with Barnidipine.Approved
IsofluraneThe risk or severity of adverse effects can be increased when Barnidipine is combined with Isoflurane.Approved, Vet Approved
Isosorbide DinitrateThe risk or severity of adverse effects can be increased when Barnidipine is combined with Isosorbide Dinitrate.Approved
Isosorbide MononitrateThe risk or severity of adverse effects can be increased when Barnidipine is combined with Isosorbide Mononitrate.Approved
IsoxsuprineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Isoxsuprine.Approved, Withdrawn
IsradipineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Isradipine.Approved
ItraconazoleThe serum concentration of Barnidipine can be increased when it is combined with Itraconazole.Approved, Investigational
JosamycinThe metabolism of Barnidipine can be decreased when combined with Josamycin.Approved, Investigational
KetoconazoleThe serum concentration of Barnidipine can be increased when it is combined with Ketoconazole.Approved, Investigational
KitasamycinThe metabolism of Barnidipine can be decreased when combined with Kitasamycin.Experimental
LabetalolLabetalol may increase the hypotensive activities of Barnidipine.Approved
LacidipineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Lacidipine.Approved, Investigational
LercanidipineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Lercanidipine.Approved, Investigational
LevobunololThe risk or severity of adverse effects can be increased when Barnidipine is combined with Levobunolol.Approved
LevobupivacaineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Levobupivacaine.Approved, Investigational
LevodopaBarnidipine may increase the orthostatic hypotensive activities of Levodopa.Approved
LevosimendanThe risk or severity of adverse effects can be increased when Barnidipine is combined with Levosimendan.Approved, Investigational
LisinoprilThe risk or severity of adverse effects can be increased when Barnidipine is combined with Lisinopril.Approved, Investigational
LofexidineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Lofexidine.Approved, Investigational
LopinavirThe serum concentration of Barnidipine can be increased when it is combined with Lopinavir.Approved
LosartanThe risk or severity of adverse effects can be increased when Barnidipine is combined with Losartan.Approved
LovastatinThe risk or severity of adverse effects can be increased when Barnidipine is combined with Lovastatin.Approved, Investigational
Magnesium HydroxideThe risk or severity of adverse effects can be increased when Barnidipine is combined with Magnesium Hydroxide.Approved
Magnesium oxideThe risk or severity of adverse effects can be increased when Barnidipine is combined with Magnesium oxide.Approved
Magnesium salicylateThe risk or severity of adverse effects can be increased when Barnidipine is combined with Magnesium salicylate.Approved
Magnesium SulfateThe risk or severity of adverse effects can be increased when Barnidipine is combined with Magnesium Sulfate.Approved, Vet Approved
MannitolThe risk or severity of adverse effects can be increased when Barnidipine is combined with Mannitol.Approved, Investigational
MecamylamineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Mecamylamine.Approved
MepartricinThe risk or severity of adverse effects can be increased when Mepartricin is combined with Barnidipine.Experimental
MethazolamideThe risk or severity of adverse effects can be increased when Barnidipine is combined with Methazolamide.Approved
MethohexitalThe metabolism of Barnidipine can be increased when combined with Methohexital.Approved
MethyclothiazideThe risk or severity of adverse effects can be increased when Barnidipine is combined with Methyclothiazide.Approved
MethyldopaThe risk or severity of adverse effects can be increased when Barnidipine is combined with Methyldopa.Approved
MethylphenobarbitalThe metabolism of Barnidipine can be increased when combined with Methylphenobarbital.Approved
MetipranololThe risk or severity of adverse effects can be increased when Barnidipine is combined with Metipranolol.Approved
MetolazoneThe risk or severity of adverse effects can be increased when Barnidipine is combined with Metolazone.Approved
MetoprololThe risk or severity of adverse effects can be increased when Barnidipine is combined with Metoprolol.Approved, Investigational
MevastatinThe risk or severity of adverse effects can be increased when Mevastatin is combined with Barnidipine.Experimental
MicafunginThe risk or severity of adverse effects can be increased when Micafungin is combined with Barnidipine.Approved, Investigational
MiconazoleThe risk or severity of adverse effects can be increased when Miconazole is combined with Barnidipine.Approved, Investigational, Vet Approved
MiltefosineThe risk or severity of adverse effects can be increased when Miltefosine is combined with Barnidipine.Approved
MinoxidilThe risk or severity of adverse effects can be increased when Barnidipine is combined with Minoxidil.Approved
MivacuriumBarnidipine may increase the neuromuscular blocking activities of Mivacurium.Approved
MoexiprilThe risk or severity of adverse effects can be increased when Barnidipine is combined with Moexipril.Approved
MonensinThe risk or severity of adverse effects can be increased when Monensin is combined with Barnidipine.Vet Approved
MorphineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Morphine.Approved, Investigational
MoxonidineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Moxonidine.Approved, Investigational
MyxothiazolThe risk or severity of adverse effects can be increased when Myxothiazol is combined with Barnidipine.Experimental
NabiloneThe risk or severity of adverse effects can be increased when Barnidipine is combined with Nabilone.Approved, Investigational
NadololThe risk or severity of adverse effects can be increased when Barnidipine is combined with Nadolol.Approved
NafcillinThe metabolism of Barnidipine can be increased when combined with Nafcillin.Approved
NaftifineThe risk or severity of adverse effects can be increased when Naftifine is combined with Barnidipine.Approved
NatamycinThe risk or severity of adverse effects can be increased when Natamycin is combined with Barnidipine.Approved
NebivololThe risk or severity of adverse effects can be increased when Barnidipine is combined with Nebivolol.Approved, Investigational
NefazodoneThe serum concentration of Barnidipine can be increased when it is combined with Nefazodone.Approved, Withdrawn
NelfinavirThe serum concentration of Barnidipine can be increased when it is combined with Nelfinavir.Approved
NesiritideThe risk or severity of adverse effects can be increased when Barnidipine is combined with Nesiritide.Approved, Investigational
NicardipineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Nicardipine.Approved
NicorandilNicorandil may increase the hypotensive activities of Barnidipine.Approved, Investigational
NifedipineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Nifedipine.Approved
NifuratelThe risk or severity of adverse effects can be increased when Nifuratel is combined with Barnidipine.Experimental
Nikkomycin ZThe risk or severity of adverse effects can be increased when Nikkomycin Z is combined with Barnidipine.Investigational
NilvadipineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Nilvadipine.Approved, Investigational
NimodipineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Nimodipine.Approved
NisoldipineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Nisoldipine.Approved
NitrendipineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Nitrendipine.Approved, Investigational
Nitric OxideThe risk or severity of adverse effects can be increased when Barnidipine is combined with Nitric Oxide.Approved
NitroglycerinThe risk or severity of adverse effects can be increased when Barnidipine is combined with Nitroglycerin.Approved, Investigational
NitroprussideBarnidipine may increase the hypotensive activities of Nitroprusside.Approved
NitroxolineThe risk or severity of adverse effects can be increased when Nitroxoline is combined with Barnidipine.Approved
NystatinThe risk or severity of adverse effects can be increased when Nystatin is combined with Barnidipine.Approved, Vet Approved
ObinutuzumabThe risk or severity of adverse effects can be increased when Barnidipine is combined with Obinutuzumab.Approved
OleandomycinThe metabolism of Barnidipine can be decreased when combined with Oleandomycin.Vet Approved
OlmesartanThe risk or severity of adverse effects can be increased when Barnidipine is combined with Olmesartan.Approved, Investigational
OmoconazoleThe risk or severity of adverse effects can be increased when Omoconazole is combined with Barnidipine.Experimental
OxiconazoleThe risk or severity of adverse effects can be increased when Oxiconazole is combined with Barnidipine.Approved
OxprenololThe risk or severity of adverse effects can be increased when Barnidipine is combined with Oxprenolol.Approved
PaclitaxelThe risk or severity of adverse effects can be increased when Barnidipine is combined with Paclitaxel.Approved, Vet Approved
pafuramidineThe risk or severity of adverse effects can be increased when pafuramidine is combined with Barnidipine.Investigational
PapaverineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Papaverine.Approved
PenbutololThe risk or severity of adverse effects can be increased when Barnidipine is combined with Penbutolol.Approved, Investigational
PentamidineThe risk or severity of adverse effects can be increased when Pentamidine is combined with Barnidipine.Approved
PentobarbitalThe metabolism of Barnidipine can be increased when combined with Pentobarbital.Approved, Vet Approved
PerindoprilThe risk or severity of adverse effects can be increased when Barnidipine is combined with Perindopril.Approved
PhenelzineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Phenelzine.Approved
PhenobarbitalThe metabolism of Barnidipine can be increased when combined with Phenobarbital.Approved
PhenoxybenzamineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Phenoxybenzamine.Approved
PhentolamineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Phentolamine.Approved
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Barnidipine.Approved, Vet Approved
PindololThe risk or severity of adverse effects can be increased when Barnidipine is combined with Pindolol.Approved
PipamperoneThe risk or severity of adverse effects can be increased when Barnidipine is combined with Pipamperone.Approved, Investigational
PitavastatinThe risk or severity of adverse effects can be increased when Barnidipine is combined with Pitavastatin.Approved
PosaconazoleThe serum concentration of Barnidipine can be increased when it is combined with Posaconazole.Approved, Investigational, Vet Approved
PramipexoleThe risk or severity of adverse effects can be increased when Barnidipine is combined with Pramipexole.Approved, Investigational
PravastatinThe risk or severity of adverse effects can be increased when Barnidipine is combined with Pravastatin.Approved
PrazosinPrazosin may increase the hypotensive activities of Barnidipine.Approved
PrimidoneThe metabolism of Barnidipine can be increased when combined with Primidone.Approved, Vet Approved
PropofolThe risk or severity of adverse effects can be increased when Barnidipine is combined with Propofol.Approved, Investigational, Vet Approved
PropranololThe risk or severity of adverse effects can be increased when Barnidipine is combined with Propranolol.Approved, Investigational
PyrrolnitrinThe risk or severity of adverse effects can be increased when Pyrrolnitrin is combined with Barnidipine.Experimental
QuetiapineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Quetiapine.Approved
QuinaprilThe risk or severity of adverse effects can be increased when Barnidipine is combined with Quinapril.Approved, Investigational
RadicicolThe risk or severity of adverse effects can be increased when Radicicol is combined with Barnidipine.Experimental
RamiprilThe risk or severity of adverse effects can be increased when Barnidipine is combined with Ramipril.Approved
RapacuroniumBarnidipine may increase the neuromuscular blocking activities of Rapacuronium.Withdrawn
RasagilineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Rasagiline.Approved
RemifentanilThe risk or severity of adverse effects can be increased when Barnidipine is combined with Remifentanil.Approved
ReserpineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Reserpine.Approved, Investigational
RifabutinThe serum concentration of Barnidipine can be decreased when it is combined with Rifabutin.Approved
RifampicinThe serum concentration of Barnidipine can be decreased when it is combined with Rifampicin.Approved
RifapentineThe serum concentration of Barnidipine can be decreased when it is combined with Rifapentine.Approved
RifaximinThe serum concentration of Barnidipine can be decreased when it is combined with Rifaximin.Approved, Investigational
RiociguatThe risk or severity of adverse effects can be increased when Barnidipine is combined with Riociguat.Approved
RisperidoneBarnidipine may increase the hypotensive activities of Risperidone.Approved, Investigational
RopiniroleThe risk or severity of adverse effects can be increased when Barnidipine is combined with Ropinirole.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Ropivacaine.Approved
RosuvastatinThe risk or severity of adverse effects can be increased when Barnidipine is combined with Rosuvastatin.Approved
RotigotineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Rotigotine.Approved
SacubitrilThe risk or severity of adverse effects can be increased when Barnidipine is combined with Sacubitril.Approved
Salicylhydroxamic AcidThe risk or severity of adverse effects can be increased when Salicylhydroxamic Acid is combined with Barnidipine.Experimental
Salicylic acidThe risk or severity of adverse effects can be increased when Salicylic acid is combined with Barnidipine.Approved, Vet Approved
SaquinavirThe serum concentration of Barnidipine can be increased when it is combined with Saquinavir.Approved, Investigational
SecobarbitalThe metabolism of Barnidipine can be increased when combined with Secobarbital.Approved, Vet Approved
SelegilineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Selegiline.Approved, Investigational, Vet Approved
SertaconazoleThe risk or severity of adverse effects can be increased when Sertaconazole is combined with Barnidipine.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Barnidipine is combined with Sevoflurane.Approved, Vet Approved
SilodosinSilodosin may increase the hypotensive activities of Barnidipine.Approved
SimvastatinThe risk or severity of adverse effects can be increased when Barnidipine is combined with Simvastatin.Approved
SinefunginThe risk or severity of adverse effects can be increased when Sinefungin is combined with Barnidipine.Experimental
SirolimusThe risk or severity of adverse effects can be increased when Sirolimus is combined with Barnidipine.Approved, Investigational
Sodium NitriteThe risk or severity of adverse effects can be increased when Barnidipine is combined with Sodium Nitrite.Approved
SolithromycinThe metabolism of Barnidipine can be decreased when combined with Solithromycin.Investigational
SotalolThe risk or severity of adverse effects can be increased when Barnidipine is combined with Sotalol.Approved
SpironolactoneThe risk or severity of adverse effects can be increased when Barnidipine is combined with Spironolactone.Approved
StiripentolThe serum concentration of Barnidipine can be increased when it is combined with Stiripentol.Approved
StreptokinaseThe risk or severity of adverse effects can be increased when Barnidipine is combined with Streptokinase.Approved, Investigational
SufentanilThe risk or severity of adverse effects can be increased when Barnidipine is combined with Sufentanil.Approved, Investigational
SulconazoleThe risk or severity of adverse effects can be increased when Sulconazole is combined with Barnidipine.Approved
TamsulosinTamsulosin may increase the hypotensive activities of Barnidipine.Approved, Investigational
TavaboroleThe risk or severity of adverse effects can be increased when Tavaborole is combined with Barnidipine.Approved
TelaprevirThe serum concentration of Barnidipine can be increased when it is combined with Telaprevir.Approved, Withdrawn
TelithromycinThe serum concentration of Barnidipine can be increased when it is combined with Telithromycin.Approved
TelmisartanThe risk or severity of adverse effects can be increased when Barnidipine is combined with Telmisartan.Approved, Investigational
TerazosinTerazosin may increase the hypotensive activities of Barnidipine.Approved
TerbinafineThe risk or severity of adverse effects can be increased when Terbinafine is combined with Barnidipine.Approved, Investigational, Vet Approved
TerconazoleThe risk or severity of adverse effects can be increased when Terconazole is combined with Barnidipine.Approved
ThalidomideThe risk or severity of adverse effects can be increased when Barnidipine is combined with Thalidomide.Approved, Investigational, Withdrawn
ThiamylalThe metabolism of Barnidipine can be increased when combined with Thiamylal.Approved, Vet Approved
ThiopentalThe metabolism of Barnidipine can be increased when combined with Thiopental.Approved, Vet Approved
ThioridazineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Thioridazine.Approved, Withdrawn
ThymolThe risk or severity of adverse effects can be increased when Thymol is combined with Barnidipine.Approved
TimololThe risk or severity of adverse effects can be increased when Barnidipine is combined with Timolol.Approved
TioconazoleThe risk or severity of adverse effects can be increased when Tioconazole is combined with Barnidipine.Approved
TizanidineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Tizanidine.Approved
TolazolineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Tolazoline.Approved, Vet Approved
TolcaponeThe risk or severity of adverse effects can be increased when Barnidipine is combined with Tolcapone.Approved, Withdrawn
TolciclateThe risk or severity of adverse effects can be increased when Tolciclate is combined with Barnidipine.Experimental
TolnaftateThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Barnidipine.Approved, Vet Approved
TorasemideThe risk or severity of adverse effects can be increased when Barnidipine is combined with Torasemide.Approved
TrandolaprilThe risk or severity of adverse effects can be increased when Barnidipine is combined with Trandolapril.Approved
TranylcypromineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Tranylcypromine.Approved
TretinoinThe risk or severity of adverse effects can be increased when Barnidipine is combined with Tretinoin.Approved, Investigational, Nutraceutical
TriamtereneThe risk or severity of adverse effects can be increased when Barnidipine is combined with Triamterene.Approved
TrimazosinTrimazosin may increase the hypotensive activities of Barnidipine.Experimental
TrimetrexateThe risk or severity of adverse effects can be increased when Trimetrexate is combined with Barnidipine.Approved, Investigational
TylosinThe metabolism of Barnidipine can be decreased when combined with Tylosin.Vet Approved
UbidecarenoneThe risk or severity of adverse effects can be increased when Barnidipine is combined with Ubidecarenone.Approved, Investigational, Nutraceutical
UrapidilUrapidil may increase the hypotensive activities of Barnidipine.Investigational
ValsartanThe risk or severity of adverse effects can be increased when Barnidipine is combined with Valsartan.Approved, Investigational
VerapamilThe risk or severity of adverse effects can be increased when Barnidipine is combined with Verapamil.Approved
VoriconazoleThe serum concentration of Barnidipine can be increased when it is combined with Voriconazole.Approved, Investigational
Food Interactions
Not Available

References

General References
  1. Malhotra HS, Plosker GL: Barnidipine. Drugs. 2001;61(7):989-96; discussion 997-8. [PubMed:11434453]
External Links
PubChem Compound
443869
PubChem Substance
310265132
ChemSpider
391959
BindingDB
50088384
ChEBI
135793
ChEMBL
CHEMBL2103761
Wikipedia
Barnidipine
ATC Codes
C08CA12 — Barnidipine

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.004 mg/mLALOGPS
logP4.12ALOGPS
logP3.51ChemAxon
logS-5.1ALOGPS
pKa (Strongest Acidic)19.47ChemAxon
pKa (Strongest Basic)7.91ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area111.01 Å2ChemAxon
Rotatable Bond Count9ChemAxon
Refractivity136.36 m3·mol-1ChemAxon
Polarizability51.03 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as dihydropyridinecarboxylic acids and derivatives. These are compounds containing a dihydropyridine moiety bearing a carboxylic acid group.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Pyridines and derivatives
Sub Class
Hydropyridines
Direct Parent
Dihydropyridinecarboxylic acids and derivatives
Alternative Parents
Nitrobenzenes / Phenylmethylamines / Benzylamines / Nitroaromatic compounds / Aralkylamines / Dicarboxylic acids and derivatives / N-alkylpyrrolidines / Vinylogous amides / Enoate esters / Methyl esters
show 12 more
Substituents
Dihydropyridinecarboxylic acid derivative / Nitrobenzene / Nitroaromatic compound / Benzylamine / Phenylmethylamine / Aralkylamine / Monocyclic benzene moiety / Dicarboxylic acid or derivatives / N-alkylpyrrolidine / Benzenoid
show 31 more
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
Not Available

Drug created on October 22, 2015 14:52 / Updated on December 01, 2017 16:14