Calcium Channel Blockers

Name
Calcium Channel Blockers
Accession Number
DBCAT000574  (DBCAT003974, DBCAT003975)
Description

A class of drugs that act by selective inhibition of calcium influx through cellular membranes. The antiarrhythmic (non-dihydropyridine) calcium channel blockers block L-type calcium-channels; most effective at SA and AV nodes; reduce rate and conduction of the cardiac muscle.

ATC Classification
Drugs
DrugDrug Description
IsradipineA dihydropyridine calcium channel blocker used for the treatment of hypertension.
DiltiazemA calcium channel blocker used to treat hypertension and to manage chronic stable angina.
NimodipineA calcium channel blocker used to improve neurological outcomes in patients with subarachnoid hemorrhage due to a ruptured intracranial aneurysm.
NisoldipineA calcium channel blocker used as monotherapy or combined with other drugs for the treatment of hypertension.
NicardipineA calcium channel blocker used for the short-term treatment of hypertension and chronic stable angina.
VerapamilA non-dihydropyridine calcium channel blocker used in the treatment of angina, arrhythmia, and hypertension.
PerhexilineFor the management of severe angina pectoris.
NifedipineA dihydropyridine calcium channel blocker indicated for the management of several subtypes of angina pectoris, and hypertension.
BepridilFor the treatment of hypertension, and chronic stable angina (classic effort-associated angina).
MibefradilFor the treatment of angina and high blood pressure.
ClevidipineA dihydropyridine L-type calcium channel blocker used to lower blood pressure when oral antihypertensive therapy is not feasible or not desirable.
NilvadipineFor the management of vasospastic angina, chronic stable angina and hypertension.
FendilineFendiline is a coronary vasodilator which inhibits calcium function in muscle cells in excitation-contraction coupling. It has been proposed as an antiarrhythmic and antianginal agent. Fendiline is non-selective.
BarnidipineIndicated for the treatment of mild to moderate essential hypertension and management of chronic stable angina.
BenidipineBenidipine is a potent and long-lasting drug indicated for the treatment of cardiovascular diseases such as hypertension, renoparenchymal hypertension and angina pectoris.
CilnidipineCilnidipine is indicated for the management of hypertension for end-organ protection. It is reported to be useful in elderly patients and in those with diabetes and albuminuria. Cilnidipine has been...
LacidipineIndicated for the treatment of hypertension either alone or in combination with other antihypertensive agents, including β-adrenoceptor antagonists, diuretics, and ACE-inhibitors .
GallopamilGallopamil has been used in trials studying the treatment of Asthma.
LidoflazineNot Annotated
AmlodipineA calcium channel blocker used to treat hypertension and angina.
LercanidipineFor the treatment of Hypertension, management of angina pectoris and Raynaud's syndrome
LamotrigineA phenyltriazine antiepileptic used to treat some types of epilepsy and bipolar I disorder.
CinnarizineFor the treatment of vertigo/meniere's disease, nausea and vomiting, motion sickness and also useful for vestibular symptoms of other origins.
FelodipineA calcium channel blocker used to treat hypertension.
NitrendipineFor the treatment of mild to moderate hypertension
FlunarizineA selective calcium-entry blocker used as migraine prophylaxis in patients with severe and frequent episodes who have not responded adequately to more common treatments.
PinaveriumA spasmolytic agent used for the symptomatic treatment of irritable bowel syndrome (IBS) and functional disorders of the biliary tract.
ManidipineFor the treatment of hypertension.
EfonidipineFor the treatment of hypertension.
Magnesium sulfateA drug used to treat convulsions during pregnancy, nephritis in children, magnesium deficiency, and tetany.
NimesulideFor the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old.
PrenylaminePrenylamine was withdrawn from the Canadian, US, and UK markets in 1988 due to concerns regarding cardiac arrhythmias.
ZiconotideAn N-type calcium channel antagonist used to manage patients with severe chronic pain who cannot tolerate, or who have not responded adequately to other treatments such as intrathecal morphine and systemic analgesics.
DotarizineInvestigated for use/treatment in migraine and cluster headaches.
TranilastFor the treatment of bronchial asthma, keloid and hypertrophic scar, and allergic disorders such as asthma, allergic rhinitis and atopic dermatitis.
EperisoneEperisone is an antispasmodic drug which relaxes both skeletal muscles and vascular smooth muscles, and demonstrates a variety of effects such as reduction of myotonia, improvement of circulation, and suppression...
Tolfenamic acidIn the information for tolfenamic acid, it is stated that this drug, being an NSAID, is effective in treating the pain associated with the acute attack of migraines in adults.
AzelnidipineFor the treatment of hypertension.
DarodipineDarodipine is a calcium channel blocker.
NiguldipineNiguldipine is a calcium channel blocker drug (CCB) with a1-adrenergic antagonist properties.
NiludipineNiludipine is a calcium channel blocker.
CarboxyamidotriazoleCarboxyamidotriazole has been used in trials studying the treatment of Lymphoma, Lung Cancer, Breast Cancer, Kidney Cancer, and Ovarian Cancer, among others.
NaftopidilNaftopidil has been investigated for the treatment of Disorder of Urinary Stent.
TetrahydropalmatineTetrahydropalmatine is under investigation in clinical trial NCT02118610 (Treatment of Schizophrenia With L-tetrahydropalmatine (l-THP): a Novel Dopamine Antagonist With Anti-inflammatory and Antiprotozoal Activity).
VinpocetineVinpocetine has been investigated for the treatment of Epilepsy.
BencyclaneA vasodilator agent found to be effective in a variety of peripheral circulation disorders. It has various other potentially useful pharmacological effects. Its mechanism may involve block of calcium channels.
OtiloniumNot Annotated
TerodilineNot Annotated
CaroverineNot Annotated
WIN 55212-2WIN 55,212-2 is a chemical described as an aminoalkylindole derivative, which produces effects similar to those of cannabinoids such as tetrahydrocannabinol (THC) but has an entirely different chemical structure. It...
SeletracetamInvestigated for use/treatment in epilepsy.
BioallethrinBioallethrin was used for lice and scabies infestation. Other pyrethroids are now used in place of bioallethrin.
ZonisamideA sulfonamide anticonvulsant used to treat partial seizures.
LoperamideA long acting antidiarrheal used to control nonspecific diarrhea and chronic diarrhea caused by inflammatory bowel disease, or gastroenteritis.
TrimethadioneAn anticonvulsant agent indicated for the control of treatment-refractory petit mal seizures.
EthosuximideAn anticonvulsant used to treat petit mal seizures.
MethsuximideA succinimide anticonvulsant that increases the seizure threshold. Primarily used for childhood absence seizures. Functions by suppressing paroxysmal spike-and-wave patterns associated with lapses of consciousness in absence seizures.
FluspirileneAn antipsychotic agent used in the treatment of schizophrenia.
CyclandelateA vasodilator used for the treatment of various blood vessel diseases, such as claudication and arteriosclerosis.
AmiodaroneA class III antiarrhythmic indicated for the treatment of recurrent hemodynamically unstable ventricular tachycardia and recurrent ventricular fibrillation.
TrimebutineA spasmolytic agent used for the symptomatic treatment of irritable bowel syndrome (IBS) and treatment of postoperative paralytic ileus following abdominal surgery.
Fish oilA source of essential fatty acids used as a source of calories in parenteral nutrition and as a dietary supplement.
NylidrinA vasodilator used to treat patients with peripheral vascular disorders, and elderly patients with symptoms associated with organic mental disorders.
AgmatineAgmatine is being studied experimentally for several indications such as cardioprotection, diabetes, decreased kidney function, neuroprotection (stroke, severe CNS injuries, epilepsy, glaucoma, and neuropathic pain), and psychiatric conditions (depression, anxiety,...
AranidipineAranidipine has been used for many years to treat angina pectoris and hypertension.
LevomentholAn organic compound used to treat mild to moderate muscle and joint pain.
PenfluridolNot Annotated
EmopamilPrevents renal injury after warm & cold ischemia.
LomerizineUsed to treat migraines.
TetrandrineNot Annotated
DexniguldipineNot Annotated
DexverapamilNot Annotated
XylometazolineA direct acting sympathomimetic agent used for the symptomatic treatment of nasal congestion and minor inflammation due to allergies or colds.
FasudilFasudil has been investigated in Carotid Stenosis.
CarvedilolA non selective beta-adrenergic antagonist used to treat mild to severe chronic heart failure, hypertension, and left ventricular dysfunction following myocardial infarction in clinically stable patients.
SOR-C13SOR-C13 is under investigation in clinical trial NCT01578564 (Safety and Tolerability Study of SOR-C13 in Subjects With Advanced Cancers Commonly Known to Express the TRPV6 Channel).
Drugs & Drug Targets
DrugTargetType
IsradipineVoltage-dependent calcium channel subunit alpha-2/delta-1target
IsradipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
IsradipineCytochrome P450 3A4enzyme
IsradipineVoltage-dependent T-type calcium channel subunit alpha-1Htarget
IsradipineVoltage-dependent calcium channel subunit alpha-2/delta-2target
IsradipineVoltage-dependent L-type calcium channel subunit beta-2target
IsradipineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
IsradipineVoltage-dependent L-type calcium channel subunit alpha-1Starget
IsradipineBile salt export pumptransporter
DiltiazemVoltage-dependent calcium channel gamma-1 subunittarget
DiltiazemCytochrome P450 3A4enzyme
DiltiazemCytochrome P450 2C19enzyme
DiltiazemCytochrome P450 2D6enzyme
DiltiazemCytochrome P450 3A5enzyme
DiltiazemCytochrome P450 3A7enzyme
DiltiazemP-glycoprotein 1transporter
DiltiazemCytochrome P450 2C8enzyme
DiltiazemSerum albumincarrier
DiltiazemAlpha-1-acid glycoprotein 1carrier
DiltiazemVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
NimodipineCytochrome P450 3A4enzyme
NimodipineMineralocorticoid receptortarget
NimodipineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
NimodipineVoltage-dependent L-type calcium channel subunit alpha-1Starget
NimodipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
NimodipineVoltage-dependent L-type calcium channel subunit beta-2target
NimodipineVoltage-dependent L-type calcium channel subunit alpha-1Ftarget
NimodipineVoltage-dependent L-type calcium channel subunit beta-1target
NimodipineVoltage-dependent L-type calcium channel subunit beta-3target
NimodipineVoltage-dependent L-type calcium channel subunit beta-4target
NimodipineAryl hydrocarbon receptortarget
NisoldipineCytochrome P450 3A4enzyme
NisoldipineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
NisoldipineVoltage-dependent L-type calcium channel subunit alpha-1Starget
NisoldipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
NisoldipineVoltage-dependent calcium channel subunit alpha-2/delta-1target
NisoldipineVoltage-dependent L-type calcium channel subunit beta-2target
NisoldipineCytochrome P450 3A5enzyme
NisoldipineCytochrome P450 3A7enzyme
NisoldipineP-glycoprotein 1transporter
NicardipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
NicardipineCytochrome P450 3A4enzyme
NicardipineCytochrome P450 2C19enzyme
NicardipineCytochrome P450 2C8enzyme
NicardipineCytochrome P450 2D6enzyme
NicardipineCalcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1Btarget
NicardipineCalcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1Atarget
NicardipineAlpha-1A adrenergic receptortarget
NicardipineAlpha-1D adrenergic receptortarget
NicardipineAlpha-1B adrenergic receptortarget
NicardipineMuscarinic acetylcholine receptor M1target
NicardipineMuscarinic acetylcholine receptor M2target
NicardipineMuscarinic acetylcholine receptor M3target
NicardipineMuscarinic acetylcholine receptor M4target
NicardipineMuscarinic acetylcholine receptor M5target
NicardipineVoltage-dependent calcium channel subunit alpha-2/delta-1target
NicardipineVoltage-dependent L-type calcium channel subunit beta-2target
NicardipineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
NicardipineCalmodulintarget
NicardipineP-glycoprotein 1transporter
NicardipineCytochrome P450 2B6enzyme
NicardipineCytochrome P450 2E1enzyme
NicardipineCytochrome P450 3A5enzyme
NicardipineSolute carrier organic anion transporter family member 1B1transporter
NicardipineBile salt export pumptransporter
NicardipineCytochrome P450 2C9enzyme
VerapamilATP-sensitive inward rectifier potassium channel 11target
VerapamilVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
VerapamilPotassium voltage-gated channel subfamily H member 2target
VerapamilVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
VerapamilCytochrome P450 1A2enzyme
VerapamilCytochrome P450 3A5enzyme
VerapamilVoltage-dependent N-type calcium channel subunit alpha-1Btarget
VerapamilVoltage-dependent P/Q-type calcium channel subunit alpha-1Atarget
VerapamilSodium-dependent serotonin transportertarget
VerapamilCytochrome P450 3A4enzyme
VerapamilP-glycoprotein 1transporter
VerapamilSolute carrier family 22 member 1transporter
VerapamilCanalicular multispecific organic anion transporter 2transporter
VerapamilMultidrug resistance-associated protein 4transporter
VerapamilSolute carrier family 22 member 5transporter
VerapamilSolute carrier organic anion transporter family member 1A2transporter
VerapamilMultidrug resistance-associated protein 7transporter
VerapamilSolute carrier family 22 member 4transporter
VerapamilSolute carrier organic anion transporter family member 1B1transporter
VerapamilCytochrome P450 2C8enzyme
VerapamilCytochrome P450 2C9enzyme
VerapamilCytochrome P450 2B6enzyme
VerapamilCytochrome P450 2C19enzyme
VerapamilCytochrome P450 2D6enzyme
VerapamilAlpha-1A adrenergic receptortarget
VerapamilAlpha-1B adrenergic receptortarget
VerapamilAlpha-1D adrenergic receptortarget
VerapamilSerum albumincarrier
VerapamilAlpha-1-acid glycoprotein 1carrier
VerapamilCytochrome P450 2C18enzyme
VerapamilCytochrome P450 2E1enzyme
VerapamilMultidrug resistance-associated protein 1transporter
VerapamilMultidrug and toxin extrusion protein 1transporter
VerapamilMultidrug and toxin extrusion protein 2transporter
VerapamilVoltage-dependent T-type calcium channel subunit alpha-1Htarget
PerhexilineCarnitine O-palmitoyltransferase 1, liver isoformtarget
PerhexilineCarnitine O-palmitoyltransferase 2, mitochondrialtarget
PerhexilineCytochrome P450 2D6enzyme
PerhexilineCytochrome P450 2B6enzyme
PerhexilineCytochrome P450 3A4enzyme
PerhexilinePotassium voltage-gated channel subfamily H member 2target
NifedipineCytochrome P450 3A4enzyme
NifedipineCytochrome P450 2E1enzyme
NifedipineCytochrome P450 2D6enzyme
NifedipineCalmodulintarget
NifedipineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
NifedipineVoltage-dependent L-type calcium channel subunit alpha-1Starget
NifedipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
NifedipineVoltage-dependent L-type calcium channel subunit beta-2target
NifedipinePotassium voltage-gated channel subfamily D member 3target
NifedipineVoltage-dependent T-type calcium channeltarget
NifedipineCytochrome P450 1A2enzyme
NifedipineCytochrome P450 2A6enzyme
NifedipineCytochrome P450 2C8enzyme
NifedipineCanalicular multispecific organic anion transporter 2transporter
NifedipineP-glycoprotein 1transporter
NifedipineCanalicular multispecific organic anion transporter 1transporter
NifedipineCytochrome P450 1A1enzyme
NifedipineCytochrome P450 2B6enzyme
NifedipineNuclear receptor subfamily 1 group I member 2target
NifedipineSolute carrier organic anion transporter family member 1B1transporter
NifedipineBile salt export pumptransporter
NifedipineCytochrome P450 2C9enzyme
NifedipineSerum albumincarrier
Nifedipinealpha1-acid glycoproteincarrier
NifedipineCytochrome P450 3A5enzyme
BepridilVoltage-dependent P/Q-type calcium channel subunit alpha-1Atarget
BepridilSodium/potassium-transporting ATPase subunit alpha-1target
BepridilPotassium voltage-gated channel subfamily KQT member 1target
BepridilTroponin C, slow skeletal and cardiac musclestarget
BepridilCalmodulintarget
BepridilVoltage-dependent T-type calcium channel subunit alpha-1Htarget
BepridilVoltage-dependent calcium channel subunit alpha-2/delta-2target
BepridilCalcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1Btarget
BepridilCalcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1Atarget
BepridilP-glycoprotein 1transporter
BepridilCytochrome P450 2D6enzyme
BepridilPotassium voltage-gated channel subfamily H member 2target
BepridilCytochrome P450 3A4enzyme
MibefradilVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
MibefradilVoltage-dependent T-type calcium channel subunit alpha-1Htarget
MibefradilVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
MibefradilVoltage-dependent L-type calcium channel subunit beta-1target
MibefradilCytochrome P450 3A4enzyme
MibefradilCytochrome P450 1A2enzyme
MibefradilCytochrome P450 2D6enzyme
MibefradilCytochrome P450 3A5enzyme
MibefradilCytochrome P450 3A7enzyme
MibefradilP-glycoprotein 1transporter
MibefradilVoltage-dependent T-type calcium channel subunit alpha-1Itarget
MibefradilVoltage-dependent L-type calcium channel subunit alpha-1Starget
MibefradilVoltage-dependent L-type calcium channel subunit alpha-1Ftarget
MibefradilVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
MibefradilVoltage-dependent L-type calcium channel subunit beta-2target
MibefradilVoltage-dependent L-type calcium channel subunit beta-3target
MibefradilVoltage-dependent L-type calcium channel subunit beta-4target
MibefradilCytochrome P450 11B1, mitochondrialenzyme
MibefradilCytochrome P450 11B2, mitochondrialenzyme
ClevidipineVoltage-dependent L-type calcium channel subunit alpha-1Ftarget
ClevidipineVoltage-dependent L-type calcium channel subunit alpha-1Starget
ClevidipineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
ClevidipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
ClevidipineCytochrome P450 2C9enzyme
ClevidipineCytochrome P450 2D6enzyme
ClevidipineCytochrome P450 2E1enzyme
ClevidipineCytochrome P450 2C19enzyme
ClevidipineCytochrome P450 3A4enzyme
ClevidipineCholinesteraseenzyme
NilvadipineCytochrome P450 3A4enzyme
NilvadipineCytochrome P450 2A6enzyme
NilvadipineCytochrome P450 2C19enzyme
NilvadipineCytochrome P450 2C8enzyme
NilvadipineCytochrome P450 2E1enzyme
NilvadipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
NilvadipineVoltage-dependent calcium channel subunit alpha-2/delta-1target
NilvadipineVoltage-dependent L-type calcium channel subunit beta-2target
NilvadipineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
NilvadipineVoltage-dependent L-type calcium channel subunit alpha-1Starget
NilvadipineVoltage-dependent calcium channel subunit alpha-2/delta-3target
FendilineCytochrome P450 3A4enzyme
BarnidipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
BarnidipineCytochrome P450 3A4enzyme
BenidipineVoltage-dependent L-type calcium channeltarget
BenidipineVoltage-dependent N-type calcium channel subunit alpha-1Btarget
BenidipineVoltage-dependent T-type calcium channeltarget
BenidipineCytochrome P450 3A4enzyme
BenidipineCytochrome P450 3A5enzyme
CilnidipineVoltage-dependent N-type calcium channel subunit alpha-1Btarget
CilnidipineVoltage-dependent L-type calcium channeltarget
CilnidipineCytochrome P450 3A4enzyme
LacidipineCytochrome P450 3A4enzyme
LacidipineSerum albumincarrier
LacidipineAlpha-1-acid glycoprotein 1carrier
LacidipineVoltage-dependent L-type calcium channeltarget
GallopamilCytochrome P450 3A4enzyme
GallopamilP-glycoprotein 1transporter
LidoflazineCytochrome P450 3A4enzyme
AmlodipineCarbonic anhydrase 1target
AmlodipineCytochrome P450 3A4enzyme
AmlodipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
AmlodipineCytochrome P450 1A1enzyme
AmlodipineCytochrome P450 2B6enzyme
AmlodipineVoltage-dependent N-type calcium channel subunit alpha-1Btarget
AmlodipineVoltage-dependent L-type calcium channel subunit beta-1target
AmlodipineVoltage-dependent calcium channel subunit alpha-2/delta-3target
AmlodipineCytochrome P450 3A5enzyme
AmlodipineP-glycoprotein 1transporter
AmlodipineCytochrome P450 2C8enzyme
AmlodipineCytochrome P450 2D6enzyme
AmlodipineSphingomyelin phosphodiesterasetarget
AmlodipineVoltage-dependent T-type calcium channel subunit alpha-1Itarget
AmlodipineVoltage-dependent N-type calcium channeltarget
LercanidipineVoltage-dependent calcium channel gamma-1 subunittarget
LercanidipineCytochrome P450 3A4enzyme
LercanidipineCytochrome P450 3A5enzyme
LercanidipineCytochrome P450 3A7enzyme
LercanidipineCytochrome P450 2D6enzyme
LamotrigineVoltage-gated sodium channel alpha subunittarget
LamotrigineUDP-glucuronosyltransferases (UGTs)enzyme
LamotrigineP-glycoprotein 1transporter
LamotrigineDihydrofolate reductaseenzyme
Lamotrigine5-hydroxytryptamine receptor 3Atarget
LamotrigineVoltage-dependent R-type calcium channel subunit alpha-1E (CACNA1E)target
LamotrigineAdenosine receptor A1target
LamotrigineAdenosine receptor A2atarget
LamotrigineAlpha-1A adrenergic receptortarget
LamotrigineAlpha-2A adrenergic receptortarget
LamotrigineBeta-1 adrenergic receptortarget
LamotrigineD(1) dopamine receptortarget
LamotrigineDopamine D2 receptortarget
LamotrigineGABA(A) Receptortarget
LamotrigineGABA(A) Receptor Benzodiazepine Binding Sitetarget
LamotrigineHistamine H1 receptortarget
LamotrigineKappa-type opioid receptortarget
LamotrigineAcetylcholine receptor subunit alphatarget
Lamotrigine5-hydroxytryptamine receptor 2Atarget
LamotrigineSolute carrier family 22 member 2transporter
LamotrigineSerum albumincarrier
LamotrigineSolute carrier family 22 member 1transporter
LamotrigineGlutamate receptor 1target
CinnarizineHistamine H1 receptortarget
CinnarizineDopamine D2 receptortarget
CinnarizineVoltage-dependent T-type calcium channel subunit alpha-1Htarget
CinnarizineCytochrome P450 2D6enzyme
CinnarizineCytochrome P450 2B6enzyme
CinnarizineCytochrome P450 2C9enzyme
CinnarizineCytochrome P450 1A1enzyme
CinnarizineCytochrome P450 1A2enzyme
CinnarizineCytochrome P450 2A6enzyme
CinnarizineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
CinnarizineVoltage-dependent L-type calcium channel subunit alpha-1Starget
CinnarizineVoltage-dependent L-type calcium channel subunit alpha-1Ftarget
CinnarizineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
CinnarizineVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
CinnarizineVoltage-dependent T-type calcium channel subunit alpha-1Itarget
CinnarizineD(1) dopamine receptortarget
CinnarizineMuscarinic acetylcholine receptortarget
CinnarizineCytochrome P450 3A4enzyme
FelodipineVoltage-dependent calcium channel subunit alpha-2/delta-1target
FelodipineCalmodulintarget
FelodipineCytochrome P450 3A4enzyme
FelodipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
FelodipineVoltage-dependent L-type calcium channel subunit beta-2target
FelodipineCytochrome P450 2C8enzyme
FelodipineCalcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1Btarget
FelodipineCalcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1Atarget
FelodipineVoltage-dependent T-type calcium channel subunit alpha-1Htarget
FelodipineVoltage-dependent calcium channel subunit alpha-2/delta-2target
FelodipineTroponin C, skeletal muscletarget
FelodipineTroponin C, slow skeletal and cardiac musclestarget
FelodipineMineralocorticoid receptortarget
FelodipineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
FelodipineVoltage-dependent L-type calcium channel subunit alpha-1Starget
FelodipineCytochrome P450 3A5enzyme
FelodipineCytochrome P450 3A7enzyme
FelodipineP-glycoprotein 1transporter
FelodipineCytochrome P450 2C9enzyme
FelodipineCytochrome P450 2D6enzyme
FelodipineBile salt export pumptransporter
NitrendipineCytochrome P450 3A4enzyme
NitrendipineVoltage-dependent T-type calcium channel subunit alpha-1Htarget
NitrendipineVoltage-dependent calcium channel subunit alpha-2/delta-2target
NitrendipineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
NitrendipineVoltage-dependent L-type calcium channel subunit alpha-1Starget
NitrendipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
NitrendipineVoltage-dependent calcium channel subunit alpha-2/delta-1target
NitrendipineVoltage-dependent L-type calcium channel subunit beta-2target
NitrendipineCytochrome P450 3A5enzyme
NitrendipineCytochrome P450 3A7enzyme
NitrendipineP-glycoprotein 1transporter
NitrendipineBile salt export pumptransporter
FlunarizineHistamine H1 receptortarget
FlunarizineVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
FlunarizineVoltage-dependent T-type calcium channel subunit alpha-1Htarget
FlunarizineVoltage-dependent T-type calcium channel subunit alpha-1Itarget
FlunarizineCalmodulintarget
FlunarizineCytochrome P450 2D6enzyme
FlunarizineCytochrome P450 2C9enzyme
FlunarizineCytochrome P450 1A1enzyme
FlunarizineCytochrome P450 1A2enzyme
FlunarizineCytochrome P450 2A6enzyme
FlunarizineCytochrome P450 3A4enzyme
PinaveriumVoltage-dependent L-type calcium channel subunit alpha-1Starget
PinaveriumCytochrome P450 3A4enzyme
ManidipineVoltage-dependent L-type calcium channeltarget
ManidipineVoltage-dependent T-type calcium channeltarget
ManidipineCytochrome P450 2C9enzyme
ManidipineCytochrome P450 2D6enzyme
ManidipineCytochrome P450 1A1enzyme
ManidipineCytochrome P450 2B6enzyme
ManidipineCytochrome P450 2C19enzyme
ManidipineCytochrome P450 3A4enzyme
EfonidipineVoltage-dependent T-type calcium channel subunit alpha-1Itarget
EfonidipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
EfonidipineCytochrome P450 3A4enzyme
Magnesium sulfateVoltage-dependent L-type calcium channeltarget
NimesulideProstaglandin G/H synthase 2target
NimesulideGroup IIE secretory phospholipase A2target
NimesulideLactotransferrintarget
NimesulideCytochrome P450 3A4enzyme
PrenylamineCalmodulintarget
PrenylamineMyosin light chain kinase 2, skeletal/cardiac muscletarget
PrenylamineCytochrome P450 3A4enzyme
ZiconotideVoltage-dependent N-type calcium channel subunit alpha-1Btarget
ZiconotideVoltage-dependent P/Q-type calcium channel subunit alpha-1Atarget
Dotarizine5-hydroxytryptamine receptor 2Atarget
Dotarizine5-hydroxytryptamine receptor 1Atarget
DotarizineVoltage-dependent P/Q-type calcium channel subunit alpha-1Atarget
Dotarizine5-hydroxytryptamine receptor 2Ctarget
DotarizineCytochrome P450 3A4enzyme
TranilastHematopoietic prostaglandin D synthasetarget
TranilastCytochrome P450 3A4enzyme
TranilastCytochrome P450 2C9enzyme
EperisoneCytochrome P450 3A4enzyme
Tolfenamic acidProstaglandin G/H synthase 1target
Tolfenamic acidProstaglandin G/H synthase 2target
Tolfenamic acidCytochrome P450 3A4enzyme
AzelnidipineCytochrome P450 3A4enzyme
AzelnidipineVoltage-dependent L-type calcium channel subunit beta-1target
DarodipineCytochrome P450 3A4enzyme
NiguldipineAlpha-1A adrenergic receptortarget
NiguldipineCytochrome P450 3A4enzyme
NiguldipineP-glycoprotein 1transporter
NiludipineCytochrome P450 3A4enzyme
CarboxyamidotriazoleCytochrome P450 3A4enzyme
NaftopidilCytochrome P450 3A4enzyme
TetrahydropalmatineDopamine D1 receptortarget
TetrahydropalmatineDopamine D2 receptortarget
TetrahydropalmatineCytochrome P450 3A4enzyme
VinpocetineCytochrome P450 3A4enzyme
BencyclaneCytochrome P450 3A4enzyme
OtiloniumCytochrome P450 3A4enzyme
TerodilineCytochrome P450 3A4enzyme
CaroverineCytochrome P450 3A4enzyme
WIN 55212-2Cytochrome P450 3A4enzyme
SeletracetamSynaptic vesicle glycoprotein 2Atarget
SeletracetamVoltage-dependent N-type calcium channel subunit alpha-1Btarget
SeletracetamGlycine receptor (alpha-1/beta)target
SeletracetamCytochrome P450 3A4enzyme
BioallethrinVoltage-gated sodium channel alpha subunittarget
BioallethrinSodium channel proteintarget
BioallethrinVoltage-dependent calcium channeltarget
BioallethrinVoltage-dependent T-type calcium channeltarget
BioallethrinVoltage-dependent P/Q-type calcium channeltarget
BioallethrinVoltage-dependent L-type calcium channeltarget
BioallethrinCytochrome P450 2C8enzyme
BioallethrinCytochrome P450 2C9enzyme
BioallethrinCytochrome P450 2C19enzyme
BioallethrinCytochrome P450 3A4enzyme
BioallethrinCytochrome P450 2A1enzyme
BioallethrinCytochrome P450 1A1enzyme
BioallethrinCytochrome P450 2C6enzyme
BioallethrinCytochrome P450 2C11enzyme
BioallethrinCytochrome P450 3A1enzyme
BioallethrinCytochrome P450 3A2enzyme
ZonisamideSodium channel protein type 1 subunit alphatarget
ZonisamideCarbonic anhydrase 1target
ZonisamideVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
ZonisamideCytochrome P450 3A4enzyme
ZonisamideAldehyde oxidaseenzyme
ZonisamideAmine oxidase [flavin-containing] Btarget
ZonisamideCarbonic anhydrase 2target
ZonisamideCarbonic anhydrase 3target
ZonisamideCarbonic anhydrase 4target
ZonisamideCarbonic anhydrase 5A, mitochondrialtarget
ZonisamideCarbonic anhydrase 5B, mitochondrialtarget
ZonisamideCarbonic anhydrase 6target
ZonisamideCarbonic anhydrase 7target
ZonisamideCarbonic anhydrase-related proteintarget
ZonisamideCarbonic anhydrase 9target
ZonisamideCarbonic anhydrase-related protein 10target
ZonisamideCarbonic anhydrase-related protein 11target
ZonisamideCarbonic anhydrase 12target
ZonisamideCarbonic anhydrase 13target
ZonisamideCarbonic anhydrase 14target
ZonisamideVoltage-dependent T-type calcium channel subunit alpha-1Htarget
ZonisamideVoltage-dependent T-type calcium channel subunit alpha-1Itarget
ZonisamideSodium channel protein type 2 subunit alphatarget
ZonisamideSodium channel protein type 3 subunit alphatarget
ZonisamideSodium channel protein type 4 subunit alphatarget
ZonisamideSodium channel protein type 5 subunit alphatarget
ZonisamideSodium channel protein type 9 subunit alphatarget
ZonisamideSodium channel protein type 11 subunit alphatarget
ZonisamideSodium channel subunit beta-1target
ZonisamideSodium channel subunit beta-2target
ZonisamideSodium channel subunit beta-3target
ZonisamideSodium channel subunit beta-4target
ZonisamideAmine oxidase [flavin-containing] Atarget
ZonisamideCytochrome P450 2C19enzyme
ZonisamideUDP-glucuronosyltransferase 1-1enzyme
ZonisamideCytochrome P450 3A5enzyme
ZonisamideP-glycoprotein 1transporter
LoperamideVoltage-dependent P/Q-type calcium channel subunit alpha-1Atarget
LoperamideMu-type opioid receptortarget
LoperamideCalmodulintarget
LoperamidePro-opiomelanocortintarget
LoperamideDelta-type opioid receptortarget
LoperamideCytochrome P450 3A4enzyme
LoperamideP-glycoprotein 1transporter
LoperamideKappa-type opioid receptortarget
LoperamideCytochrome P450 2C8enzyme
LoperamideCytochrome P450 2B6enzyme
LoperamideCytochrome P450 2D6enzyme
LoperamideNuclear receptor subfamily 1 group I member 3target
TrimethadioneVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
TrimethadioneCytochrome P450 2C19enzyme
TrimethadioneCytochrome P450 2C8enzyme
TrimethadioneCytochrome P450 2C9enzyme
TrimethadioneCytochrome P450 2E1enzyme
TrimethadioneCytochrome P450 3A4enzyme
EthosuximideVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
EthosuximideCytochrome P450 3A4enzyme
EthosuximideCytochrome P450 2E1enzyme
EthosuximideCytochrome P450 3A Subfamilyenzyme
MethsuximideCytochrome P450 2C19enzyme
MethsuximideVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
FluspirileneDopamine D2 receptortarget
Fluspirilene5-hydroxytryptamine receptor 2Atarget
FluspirileneVoltage-dependent calcium channel gamma-1 subunittarget
FluspirileneCytochrome P450 3A4enzyme
CyclandelateVoltage-dependent calcium channel subunit alpha-2/delta-1target
CyclandelateLiver carboxylesterase 1target
CyclandelateCytochrome P450 3A4enzyme
AmiodaroneBeta adrenergic receptortarget
AmiodaroneHERG human cardiac K+ channeltarget
AmiodaroneCytochrome P450 2C8enzyme
AmiodaroneCytochrome P450 2C9enzyme
AmiodaroneCytochrome P450 2D6enzyme
AmiodaroneVoltage-dependent T-type calcium channel subunit alpha-1Itarget
AmiodaroneVoltage gated L-type calcium channeltarget
AmiodaroneCytochrome P450 3A4enzyme
AmiodaroneCytochrome P450 1A2enzyme
AmiodaroneCytochrome P450 1A1enzyme
AmiodaroneP-glycoprotein 1transporter
AmiodaroneCytochrome P450 2C19enzyme
AmiodaroneCytochrome P450 2A6enzyme
AmiodaroneThyroid hormone receptortarget
AmiodaronePeroxisome proliferator-activated receptor gammatarget
AmiodaroneBile salt export pumptransporter
AmiodaroneSolute carrier family 22 member 2transporter
AmiodaroneCytochrome P450 2J2enzyme
AmiodaronePeroxisome proliferator-activated receptor alphatarget
AmiodaronePeroxisome proliferator-activated receptor gamma coactivator 1-betatarget
AmiodaroneSerum albumincarrier
TrimebutineMu-type opioid receptortarget
TrimebutineVoltage-dependent L-type calcium channeltarget
TrimebutineCalcium-activated potassium channeltarget
TrimebutineVoltage-dependent T-type calcium channeltarget
TrimebutineMuscarinic acetylcholine receptor M1target
TrimebutineMuscarinic acetylcholine receptor M2target
TrimebutineMuscarinic acetylcholine receptor M3target
TrimebutineMuscarinic acetylcholine receptor M4target
TrimebutineCytochrome P450 3A4enzyme
Fish oilDiacylglycerol O-acyltransferase 2target
Fish oilProstaglandin G/H synthase 2target
Fish oilFree fatty acid receptor 4target
Fish oilVoltage gated L-type calcium channeltarget
Fish oilSodium channel proteintarget
Fish oilFree radicalstarget
Fish oilNuclear factor NF-kappa-Btarget
Fish oilSterol regulatory element-binding protein 1target
Fish oilPeroxisome proliferator-activated receptor alphatarget
Fish oilPeroxisome proliferator-activated receptor gammatarget
Fish oilPeroxisome proliferator-activated receptor deltatarget
Fish oilCytochrome P450 3A4enzyme
NylidrinCatechol O-methyltransferaseenzyme
NylidrinVoltage-dependent T-type calcium channel subunit alpha-1Itarget
NylidrinInterferon alpha/beta receptor 2target
NylidrinCytochrome P450 3A4enzyme
AgmatineSolute carrier family 22 member 1transporter
AgmatineSolute carrier family 22 member 2transporter
AgmatineSolute carrier family 22 member 3transporter
AgmatineAlpha-2C adrenergic receptortarget
AgmatineNischarintarget
AgmatineAcetylcholine receptor subunit alphatarget
AgmatineGlutamate receptor ionotropic, NMDA 1target
AgmatineATP-sensitive inward rectifier potassium channel 1target
AgmatineVoltage-dependent N-type calcium channel subunit alpha-1Btarget
AgmatineAcid-sensing ion channel 3target
AgmatineY+L amino acid transporter 1transporter
AgmatineCytochrome P450 3A4enzyme
AranidipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
AranidipineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
AranidipineVoltage-dependent L-type calcium channel subunit alpha-1Ftarget
AranidipineVoltage-dependent L-type calcium channel subunit alpha-1Starget
AranidipineAlpha adrenergic receptortarget
AranidipineSerum albumincarrier
AranidipineAlpha-1-acid glycoprotein 1carrier
AranidipineCytochrome P450 3A4enzyme
LevomentholTransient receptor potential cation channel subfamily A member 1target
LevomentholTransient receptor potential cation channel subfamily M member 8target
LevomentholTransient receptor potential cation channel subfamily V member 3target
LevomentholKappa-type opioid receptortarget
LevomentholVoltage-dependent L-type calcium channeltarget
LevomentholCytochrome P450 3A4enzyme
PenfluridolCytochrome P450 3A4enzyme
EmopamilP-glycoprotein 1target
EmopamilCytochrome P450 3A4enzyme
EmopamilP-glycoprotein 1transporter
LomerizineP-glycoprotein 1target
LomerizineCytochrome P450 3A4enzyme
LomerizineP-glycoprotein 1transporter
TetrandrineP-glycoprotein 1target
TetrandrineCytochrome P450 3A4enzyme
TetrandrineP-glycoprotein 1transporter
DexniguldipineP-glycoprotein 1target
DexniguldipineCytochrome P450 3A4enzyme
DexverapamilP-glycoprotein 1target
DexverapamilCytochrome P450 3A4enzyme
DexverapamilP-glycoprotein 1transporter
XylometazolineAlpha-2A adrenergic receptortarget
XylometazolineAlpha-1A adrenergic receptortarget
XylometazolineAlpha-1B adrenergic receptortarget
XylometazolineAlpha-1D adrenergic receptortarget
XylometazolineAlpha-2B adrenergic receptortarget
XylometazolineAlpha-2C adrenergic receptortarget
FasudilcAMP-dependent protein kinase inhibitor alphatarget
FasudilcAMP-dependent protein kinase catalytic subunit alphatarget
FasudilRho-associated protein kinase 1target
FasudilRho-associated protein kinase 2target
CarvedilolAlpha-1A adrenergic receptortarget
CarvedilolBeta-1 adrenergic receptortarget
CarvedilolNADH dehydrogenase [ubiquinone] 1 subunit C2target
CarvedilolBeta-2 adrenergic receptortarget
CarvedilolVascular endothelial growth factor Atarget
CarvedilolNatriuretic peptides Btarget
CarvedilolGap junction alpha-1 proteintarget
CarvedilolPotassium voltage-gated channel subfamily H member 2target
CarvedilolVascular cell adhesion protein 1target
CarvedilolCytochrome P450 2C9enzyme
CarvedilolCytochrome P450 2D6enzyme
CarvedilolXanthine dehydrogenase/oxidaseenzyme
CarvedilolP-glycoprotein 1transporter
CarvedilolCytochrome P450 1A2enzyme
CarvedilolCytochrome P450 3A4enzyme
CarvedilolCytochrome P450 1A1enzyme
CarvedilolCytochrome P450 2E1enzyme
CarvedilolAlpha-1D adrenergic receptortarget
CarvedilolAlpha-1B adrenergic receptortarget
CarvedilolAlpha-2C adrenergic receptortarget
CarvedilolAlpha-2B adrenergic receptortarget
CarvedilolAlpha-2A adrenergic receptortarget
CarvedilolE-selectintarget
CarvedilolHypoxia-inducible factor 1-alphatarget
CarvedilolInward rectifier potassium channel 4target
CarvedilolUDP-glucuronosyltransferase 1-1enzyme
CarvedilolSerum albumincarrier
CarvedilolUDP-glucuronosyltransferase 2B4enzyme
CarvedilolUDP-glucuronosyltransferase 2B7enzyme
CarvedilolInward rectifier potassium channel 2target
CarvedilolAlpha-1 adrenergic receptorstarget