Irritable Bowel Syndrome (IBS)

Also known as: Irritable Bowel Disease / IBS (Irritable Bowel Syndrome) / IBS / IBS - Irritable Bowel Syndrome / Irritable Bowel / Colitis, Mucous / Irritable Colon / Colon, Irritable / Irritable Bowel Syndrome(IBS) / Irritable Bowel Syndrome / Mucous colitis / Colitis mucous / Irritable bowel syndrome NOS / Colon spastic / Spastic colon / Irritable colon syndrome / [X]Psychogenic IBS / Functional bowel syndrome

DrugDrug NameDrug Description
DB00321AmitriptylineA tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety.
DB00771ClidiniumA synthetic anticholinergic used to treat peptic ulcer disease, colicky abdominal pain, diverticulitis, and IBS.
DB01151DesipramineA tricyclic antidepressant used in the treatment of depression.
DB00804DicyclomineAn antimuscarinic agent used to treat IBS.
DB00424HyoscyamineFor treatment of bladder spasms, peptic ulcer disease, diverticulitis, colic, irritable bowel syndrome, cystitis, and pancreatitis. Also used to treat certain heart conditions, to control the symptoms of Parkinson's disease...
DB01046LubiprostoneA prostaglandin derivative used to treat constipation caused by irritable bowel syndrome and opioid-use.
DB12554MebeverineMebeverine has been investigated for the treatment of Irritable Bowel Syndrome and Post-cholecystectomy Gastrointestinal Spasms.
DB00540NortriptylineA tricyclic antidepressant used in the treatment of depression.
DB00715ParoxetineA selective serotonin reuptake inhibitor used to treat major depressive disorder, panic disorder, OCD, social phobia, generalized anxiety disorder, the vasomotor symptoms of menopause, and premenstrual dysphoric disorder.
DB09090PinaveriumA spasmolytic agent used for the symptomatic treatment of irritable bowel syndrome (IBS) and functional disorders of the biliary tract.
DB01220RifaximinA rifamycin-based non-systemic antibiotic used for the treatment of gastrointestinal bacterial infections, such as traveler's diarrhea and irritable bowel syndrome, and reduction of overt hepatic encephalopathy recurrence in adults.
DB09089TrimebutineA spasmolytic agent used for the symptomatic treatment of irritable bowel syndrome (IBS) and treatment of postoperative paralytic ileus following abdominal surgery.
DrugDrug NameTargetType
DB00321AmitriptylineSodium-dependent serotonin transportertarget
DB00321AmitriptylineSodium-dependent noradrenaline transportertarget
DB00321AmitriptylinePotassium voltage-gated channel subfamily KQT member 2target
DB00321AmitriptylineAlpha-2A adrenergic receptortarget
DB00321AmitriptylineCytochrome P450 1A2enzyme
DB00321AmitriptylineCytochrome P450 2C19enzyme
DB00321AmitriptylineCytochrome P450 2D6enzyme
DB00321AmitriptylineSerum albumincarrier
DB00321AmitriptylineAlpha-1-acid glycoprotein 1carrier
DB00321AmitriptylineHistamine H1 receptortarget
DB00321Amitriptyline5-hydroxytryptamine receptor 2Atarget
DB00321Amitriptyline5-hydroxytryptamine receptor 1Atarget
DB00321AmitriptylineAlpha-1A adrenergic receptortarget
DB00321AmitriptylineCytochrome P450 3A4enzyme
DB00321AmitriptylineCytochrome P450 3A5enzyme
DB00321AmitriptylinePotassium voltage-gated channel subfamily A member 1target
DB00321AmitriptylineAlpha-1D adrenergic receptortarget
DB00321AmitriptylineDelta-type opioid receptortarget
DB00321AmitriptylineKappa-type opioid receptortarget
DB00321AmitriptylineHigh affinity nerve growth factor receptortarget
DB00321AmitriptylineBDNF/NT-3 growth factors receptortarget
DB00321AmitriptylineCytochrome P450 2C9enzyme
DB00321AmitriptylineCytochrome P450 2B6enzyme
DB00321AmitriptylineCytochrome P450 2C8enzyme
DB00321AmitriptylineHistamine H2 receptortarget
DB00321AmitriptylineHistamine H4 receptortarget
DB00321AmitriptylineSigma non-opioid intracellular receptor 1target
DB00321Amitriptyline5-hydroxytryptamine receptor 2Ctarget
DB00321AmitriptylineAlpha-1B adrenergic receptortarget
DB00321Amitriptyline5-hydroxytryptamine receptor 7target
DB00321Amitriptyline5-hydroxytryptamine receptor 1Dtarget
DB00321AmitriptylineMu-type opioid receptortarget
DB00321Amitriptyline5-hydroxytryptamine receptor 1Btarget
DB00321Amitriptyline5-hydroxytryptamine receptor 6target
DB00321AmitriptylinePotassium voltage-gated channel subfamily KQT member 3target
DB00321AmitriptylineUDP-glucuronosyltransferase 2B10enzyme
DB00321Amitriptyline5-hydroxytryptamine receptor 1Ctarget
DB00321AmitriptylineMuscarinic acetylcholine receptortarget
DB00321AmitriptylineHERG human cardiac K+ channeltarget
DB00321AmitriptylineP-glycoprotein 1transporter
DB00321AmitriptylineUDP-glucuronosyltransferase 1-4enzyme
DB00771ClidiniumMuscarinic acetylcholine receptor M1target
DB01151DesipramineMuscarinic acetylcholine receptor M1target
DB01151DesipramineSodium-dependent noradrenaline transportertarget
DB01151DesipramineBeta-2 adrenergic receptortarget
DB01151DesipramineMuscarinic acetylcholine receptor M2target
DB01151DesipramineSodium-dependent serotonin transportertarget
DB01151DesipramineHistamine H1 receptortarget
DB01151DesipramineBeta-1 adrenergic receptortarget
DB01151DesipramineCytochrome P450 2D6enzyme
DB01151DesipramineMuscarinic acetylcholine receptor M3target
DB01151DesipramineMuscarinic acetylcholine receptor M4target
DB01151DesipramineMuscarinic acetylcholine receptor M5target
DB01151DesipramineAlpha-1 adrenergic receptorstarget
DB01151Desipramine5-hydroxytryptamine receptor 2Atarget
DB01151DesipramineAlpha-1-acid glycoprotein 1carrier
DB01151DesipramineCytochrome P450 2B6enzyme
DB01151DesipramineCytochrome P450 3A4enzyme
DB01151DesipramineSolute carrier family 22 member 2transporter
DB01151DesipramineSolute carrier family 22 member 1transporter
DB01151DesipramineSolute carrier family 22 member 3transporter
DB01151DesipramineSolute carrier family 22 member 5transporter
DB01151DesipramineP-glycoprotein 1transporter
DB01151DesipramineSolute carrier family 22 member 4transporter
DB01151DesipramineCytochrome P450 1A2enzyme
DB01151DesipramineCytochrome P450 2E1enzyme
DB01151DesipramineSphingomyelin phosphodiesterasetarget
DB01151Desipramine5-hydroxytryptamine receptor 1Atarget
DB01151Desipramine5-hydroxytryptamine receptor 2Ctarget
DB01151DesipramineDopamine D2 receptortarget
DB01151DesipramineAlpha-2 adrenergic receptorstarget
DB00804DicyclomineMuscarinic acetylcholine receptor M1target
DB00804DicyclomineMuscarinic acetylcholine receptor M2target
DB00424HyoscyamineMuscarinic acetylcholine receptor M1target
DB00424HyoscyamineMuscarinic acetylcholine receptor M2target
DB00424HyoscyamineMuscarinic acetylcholine receptor M3target
DB00424HyoscyamineMuscarinic acetylcholine receptor M4target
DB01046LubiprostoneChloride channel protein 2target
DB01046LubiprostoneCarbonyl reductase [NADPH] 1enzyme
DB00540NortriptylineSodium-dependent serotonin transportertarget
DB00540NortriptylineSodium-dependent noradrenaline transportertarget
DB00540NortriptylineCytochrome P450 1A2enzyme
DB00540NortriptylineCytochrome P450 2D6enzyme
DB00540NortriptylineSerum albumincarrier
DB00540NortriptylineAlpha-1-acid glycoprotein 1carrier
DB00540NortriptylineHistamine H1 receptortarget
DB00540Nortriptyline5-hydroxytryptamine receptor 2Atarget
DB00540NortriptylineAlpha-1A adrenergic receptortarget
DB00540Nortriptyline5-hydroxytryptamine receptor 1Atarget
DB00540NortriptylineCytochrome P450 3A4enzyme
DB00540NortriptylineCytochrome P450 3A5enzyme
DB00540NortriptylineAlpha-1D adrenergic receptortarget
DB00540NortriptylineCytochrome P450 2C19enzyme
DB00540NortriptylineCytochrome P450 2E1enzyme
DB00540Nortriptyline5-hydroxytryptamine receptor 2Ctarget
DB00540NortriptylineAlpha-1B adrenergic receptortarget
DB00540NortriptylineAlpha-2 adrenergic receptorstarget
DB00540NortriptylineBeta adrenergic receptortarget
DB00540NortriptylineDopamine D2 receptortarget
DB00540NortriptylineSigma receptortarget
DB00540Nortriptyline5-hydroxytryptamine receptor 1Ctarget
DB00540NortriptylineSodium-dependent noradrenaline transportertransporter
DB00540NortriptylineMuscarinic acetylcholine receptortarget
DB00540NortriptylineP-glycoprotein 1transporter
DB00715ParoxetineSodium-dependent serotonin transportertarget
DB00715ParoxetineSodium-dependent noradrenaline transportertarget
DB00715Paroxetine5-hydroxytryptamine receptor 2Atarget
DB00715ParoxetineCytochrome P450 2D6enzyme
DB00715ParoxetineCytochrome P450 2C9enzyme
DB00715ParoxetineP-glycoprotein 1transporter
DB00715ParoxetineCytochrome P450 2B6enzyme
DB00715ParoxetineCytochrome P450 1A2enzyme
DB00715ParoxetineCytochrome P450 3A4enzyme
DB00715ParoxetineAlpha-1 adrenergic receptorstarget
DB00715ParoxetineAlpha-2 adrenergic receptorstarget
DB00715ParoxetineBeta adrenergic receptortarget
DB00715ParoxetineDopamine D2 receptortarget
DB00715ParoxetineHistamine H1 receptortarget
DB00715ParoxetineSerotonin Receptorstarget
DB00715ParoxetineMuscarinic acetylcholine receptortarget
DB00715Paroxetine5-hydroxytryptamine receptor 2Btarget
DB00715ParoxetineD(1) dopamine receptortarget
DB00715ParoxetineCytochrome P450 2C19enzyme
DB09090PinaveriumVoltage-dependent L-type calcium channel subunit alpha-1Starget
DB09090PinaveriumCytochrome P450 3A4enzyme
DB01220RifaximinDNA-directed RNA polymerase subunit betatarget
DB01220RifaximinNuclear receptor subfamily 1 group I member 2target
DB01220RifaximinCytochrome P450 3A4enzyme
DB01220RifaximinCytochrome P450 2C19enzyme
DB01220RifaximinCytochrome P450 2C8enzyme
DB09089TrimebutineMu-type opioid receptortarget
DB09089TrimebutineVoltage-dependent L-type calcium channeltarget
DB09089TrimebutineCalcium-activated potassium channeltarget
DB09089TrimebutineVoltage-dependent T-type calcium channeltarget
DB09089TrimebutineMuscarinic acetylcholine receptor M1target
DB09089TrimebutineMuscarinic acetylcholine receptor M2target
DB09089TrimebutineMuscarinic acetylcholine receptor M3target
DB09089TrimebutineMuscarinic acetylcholine receptor M4target
DB09089TrimebutineCytochrome P450 3A4enzyme
DrugDrug NamePhaseStatusCount
DB05072AV6081Terminated1
DB12853DA-68861Unknown Status1
DB12910Emicerfont1Completed1
DB00693Fluorescein1Suspended1
DB08890Linaclotide1Completed1
DB01046Lubiprostone1Completed2
DB01065Melatonin1Withdrawn1
DB00379Mexiletine1Completed1
DB00104Octreotide1Completed1
DB11198Peppermint oil1Withdrawn1
DB09512Simethicone1Withdrawn1
DB06190Solabegron1Completed1
DB12467TU-1001 / 2Completed1
DB05269Activated charcoal2Completed1
DB09278Activated charcoal2Completed1
DB00969Alosetron2Completed1
DB05104Asimadoline2Completed2
DB00215Citalopram2Completed1
DB00930Colesevelam2Completed1
DB04941Crofelemer2Completed2
DB05642DDP-2252Completed1
DB05049DDP7332Completed1
DB06582Dextofisopam2Completed1
DB00514Dextromethorphan2Completed1
DB11074Dimethicone2Recruiting1
DB01142Doxepin2Completed1
DB00470Dronabinol2Completed2
DB09272Eluxadoline2Completed1
DB09272Eluxadoline2Recruiting1
DB12910Emicerfont2Completed2
DB12910Emicerfont2Withdrawn1
DB00783Estradiol2Recruiting1
DB00593Ethosuximide2Recruiting1
DB00813Fentanyl2Completed1
DB12042Ibodutant2Completed1
DB04924Itopride2Completed1
DB00130L-Glutamine2Completed1
DB05199LX10312Completed1
DB00281Lidocaine2Completed1
DB00281Lidocaine2Recruiting1
DB08890Linaclotide2Completed1
DB01046Lubiprostone2Terminated1
DB00244Mesalazine2Completed2
DB14158Microcrystalline cellulose2Completed1
DB04896Milnacipran2Terminated1
DB01183Naloxone2Completed1
DB00540Nortriptyline2Completed1
DB00540Nortriptyline2Recruiting1
DB14802ONO-29522Completed1
DB14802ONO-29522Terminated1
DB14998Olorinab2Recruiting1
DB11198Peppermint oil2Completed1
DB11058Petrolatum2Recruiting1
DB00230Pregabalin2Completed1
DB09290Ramosetron2Completed2
DB12798Relenopride2Completed1
DB12143Rezatomidine2Terminated1
DB01220Rifaximin2Completed2
DB01220Rifaximin2Recruiting1
DB11883SB-7054982Terminated1
DB06190Solabegron2Completed1
DB01323St. John's Wort2Completed1
DB06429Talnetant2Completed1
DB12512Verucerfont2Withdrawn1
DB14895Vibegron2Active Not Recruiting1
DB05049DDP7332 / 3Unknown Status1
DB00244Mesalazine2 / 3Completed1
DB00141N-Acetylglucosamine2 / 3Recruiting1
DB01220Rifaximin2 / 3Recruiting2
DB09089Trimebutine2 / 3Completed1
DB14691Willow bark2 / 3Recruiting1
DB00969Alosetron3Completed2
DB14222Bifidobacterium longum infantis3Completed1
DB01151Desipramine3Completed1
DB04856Dexloxiglumide3Completed1
DB09272Eluxadoline3Completed2
DB00593Ethosuximide3Recruiting1
DB01046Lubiprostone3Completed1
DB12554Mebeverine3Recruiting1
DB01065Melatonin3Recruiting1
DB00244Mesalazine3Completed2
DB00141N-Acetylglucosamine3Recruiting1
DB00904Ondansetron3Recruiting1
DB11198Peppermint oil3Completed1
DB06377Plecanatide3Completed1
DB09290Ramosetron3Completed1
DB04917Renzapride3Completed1
DB09532Secretin human3Not Yet Recruiting1
DB00969Alosetron4Completed1
DB01616Alverine4Completed3
DB11347Bacillus subtilis4Recruiting1
DB14222Bifidobacterium longum infantis4Completed2
DB00476Duloxetine4Completed3
DB11742Ebastine4Completed1
DB11742Ebastine4Recruiting1
DB14225Enterococcus faecium4Recruiting1
DB01175Escitalopram4Completed2
DB13042Fenoverine4Completed1
DB00813Fentanyl4Completed1
DB00996Gabapentin4Terminated1
DB11360Lactobacillus plantarum4Completed1
DB12554Mebeverine4Completed1
DB11228Methylcellulose4Completed1
DB11228Methylcellulose4Unknown Status1
DB00916Metronidazole4Completed1
DB14158Microcrystalline cellulose4Completed1
DB00683Midazolam4Completed1
DB00507Nitazoxanide4Completed1
DB13500Otilonium4Recruiting1
DB00085Pancrelipase4Completed1
DB00715Paroxetine4Completed1
DB00806Pentoxifylline4Unknown Status1
DB00230Pregabalin4Completed1
DB00818Propofol4Completed1
DB09290Ramosetron4Completed2
DB01220Rifaximin4Recruiting3
DB09512Simethicone4Completed3
DB09089Trimebutine4Completed1
DB00321AmitriptylineNot AvailableNot Yet Recruiting1
DB01151DesipramineNot AvailableActive Not Recruiting1
DB00424HyoscyamineNot AvailableRecruiting1
DB08890LinaclotideNot AvailableEnrolling by Invitation1
DB01046LubiprostoneNot AvailableCompleted1
DB09567Olive oilNot AvailableCompleted1
DB02959OxitriptanNot AvailableCompleted1
DB09090PinaveriumNot AvailableActive Not Recruiting1
DB09090PinaveriumNot AvailableUnknown Status1
DB01220RifaximinNot AvailableCompleted2
DB01220RifaximinNot AvailableNot Yet Recruiting1