Drugs for Constipation

DrugDrug NameDrug Description
DB00581LactuloseA disaccharide derivative of lactose used to treat constipation and portal systemic encephalopathy.
DB01046LubiprostoneA prostaglandin derivative used to treat constipation caused by irritable bowel syndrome and opioid-use.
DB01079TegaserodA serotonin-4 (5-HT4) receptor agonist indicated for the treatment of constipation predominant irritable bowel syndrome (IBS-C) specifically in women under the age of 65. There is currently no safety or efficacy data for use of tegaserol in men.
DB04816DantronWithdrawn from the Canadian, US, and UK markets in 1998 due to genotoxicity.
DB04823OxyphenisatinA laxative that undergoes enterohepatic circulation. It may cause jaundice.
DB04824PhenolphthaleinUsed for over a century as a laxative.
DB06274AlvimopanAn opioid antagonist used to reduce healing time of the upper and lower gastrointestinal tract following surgical procedures that involve bowel resection with primary anastomosis.
DB06480PrucaloprideA P2Y12 platelet receptor antagonist used during percutaneous coronary intervention to reduce the risk for periprocedural myocardial infarction (MI), repeat coronary revascularization, and stent thrombosis (ST).
DB06800MethylnaltrexoneA μ-opioid antagonist used for the treatment of opioid-induced constipation in palliative patients that are inadequately responding to laxative therapy.
DB08890LinaclotideA guanylate cyclase-C agonist used to treat constipation associated with irritable bowel syndrome or that is idiopathic in nature.
DB09020BisacodylA stimulant laxative used for the temporary relief of occasional constipation and cleansing of the colon as a preparation for colonoscopy in adults.
DB09049NaloxegolA peripherally-selective opioid antagonist used to treat opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain.
DB09219BisoxatinFor use in the treatment of constipation in the absence of bowel obstruction and for surgical preparation of the colon .
DB09268Picosulfuric acidA stimulant laxative used for cleansing of the colon as a preparation for colonoscopy in adults.
DB09287Polyethylene glycolA laxative used to treat constipation and used for bowel preparation before colonoscopies and other procedures.
DB09462GlycerinIt is used as a solvent, emollient, pharmaceutical agent, and sweetening agent.
DB09472Sodium sulfateAn agent used for bowel cleansing prior to colonoscopy or barium enema X-ray examination.
DB09481Magnesium carbonateAn antacid used for symptomatic relief of heartburn, indigestion, and upset stomach.
DB11057Mineral oilMineral oil is not considered an active pharmacological ingredient in pharmaceutical preparations and so has no official indication. It is typically present in topical formulations as an emollient and occlusive...
DB11089DocusateA medication used to treat constipation associated with dry, hard stools, or opioid induced constipation.
DB11110Magnesium citrateA laxative used in bowel preparation for colonoscopy or as a magnesium supplement.
DB11113Castor oilAn ingredient used in a variety of natural health products.
DB11228MethylcelluloseA compound used as a bulk forming laxative and is not an approved medication.
DB11365SennosidesA laxative used to treat constipation.
DB12942LactitolLactitol has been used in trials studying the treatment of Bacterial Colonization.
DB13157Sodium lauryl sulfoacetateSodium lauryl sulfoacetate is not an active pharmacological ingredient in pharmaceutical preparations and so has no official indication.
DB13526PentaerithritylNot Annotated
DB13707Sodium tartrateIt acts as an emulsifier and pH control agent in food products , . In the laboratory, it is used while performing the Karl Fischer equation, which is used to...
DB00653Magnesium sulfateA drug used to treat convulsions during pregnancy, nephritis in children, magnesium deficiency, and tetany.
DB00742MannitolA sugar alcohol used to test for asthma, to reduce intracranial and intraocular pressure, and to measure glomerular filtration rate.
DB01377Magnesium oxideA compound commonly used as a laxative for the symptomatic relief of acid indigestion and upset stomach, and in health supplements for cardiovascular and neuromuscular health.
DB01638SorbitolA product that can be used as a laxative to relieve constipation, and also as a urologic irrigating fluid. May also be used as a pharmaceutical sweetener.
DB13486Magnesium peroxideNot Annotated
DB14585Plantago ovata seedNot Annotated
DB14684Calcium polycarbophilA bulk forming laxative used to treat constipation.
DB01183NaloxoneAn opioid receptor antagonist used to rapidly reverse an opioid overdose. Also included in some drug formulations as an abuse deterrent to prevent injection.
DB11691NaldemedineAn opioid antagonist used to to treat opioid-induced constipation.
DB13170PlecanatideA laxative used to treat chronic idiopathic constipation and IBS with constipation.
DrugDrug NameTargetType
DB00581LactuloseEvolved beta-galactosidase subunit alphatarget
DB01046LubiprostoneChloride channel protein 2target
DB01046LubiprostoneCarbonyl reductase [NADPH] 1enzyme
DB01079Tegaserod5-hydroxytryptamine receptor 4target
DB01079Tegaserod5-hydroxytryptamine receptor 2Btarget
DB01079Tegaserod5-hydroxytryptamine receptor 2Ctarget
DB01079Tegaserod5-hydroxytryptamine receptor 2Atarget
DB01079TegaserodSodium-dependent serotonin transportertransporter
DB01079TegaserodCytochrome P450 1A2enzyme
DB01079TegaserodCytochrome P450 2C8enzyme
DB01079TegaserodCytochrome P450 2D6enzyme
DB01079TegaserodCytochrome P450 2E1enzyme
DB01079TegaserodATP-binding cassette sub-family G member 2transporter
DB01079TegaserodP-glycoprotein 1transporter
DB04816DantronSerum albumincarrier
DB04824PhenolphthaleinUDP-glucuronosyltransferase 1-9target
DB04824PhenolphthaleinNuclear receptor subfamily 1 group I member 2target
DB04824PhenolphthaleinNuclear receptor subfamily 1 group I member 3target
DB04824PhenolphthaleinEstrogen receptor alphatarget
DB04824PhenolphthaleinSex hormone-binding globulintarget
DB06274AlvimopanMu-type opioid receptortarget
DB06274AlvimopanKappa-type opioid receptortarget
DB06274AlvimopanDelta-type opioid receptortarget
DB06480Prucalopride5-hydroxytryptamine receptor 4target
DB06480PrucaloprideCytochrome P450 3A4enzyme
DB06480PrucaloprideSerum albumincarrier
DB06480PrucaloprideP-glycoprotein 1transporter
DB06800MethylnaltrexoneMu-type opioid receptortarget
DB06800MethylnaltrexoneKappa-type opioid receptortarget
DB08890LinaclotideHeat-stable enterotoxin receptortarget
DB09049NaloxegolCytochrome P450 3A4enzyme
DB09049NaloxegolCytochrome P450 2D6enzyme
DB09049NaloxegolCytochrome P450 2C19enzyme
DB09049NaloxegolMu-type opioid receptortarget
DB09268Picosulfuric acidArylsulfate sulfotransferaseenzyme
DB09462GlycerinHematopoietic prostaglandin D synthasetarget
DB09462GlycerinEndoglucanase Gtarget
DB09462GlycerinGlutathione S-transferase Ptarget
DB09462GlycerinGroup IIE secretory phospholipase A2target
DB09462GlycerinInositol-3-phosphate synthase 1target
DB09462GlycerinC4-dicarboxylate transport transcriptional regulatory protein DctDtarget
DB09462GlycerinAlcohol dehydrogenase 1Btarget
DB09462GlycerinInositol 1,4,5-trisphosphate receptor type 1target
DB09462GlycerinCytochrome c4target
DB09462GlycerinTGF-beta receptor type-2target
DB09462GlycerinArgininosuccinate synthasetarget
DB09462GlycerinADP-ribosylation factor 1target
DB09462GlycerinMultidrug resistance protein MexAtarget
DB09462GlycerinBifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1target
DB09462GlycerinHistidinol dehydrogenasetarget
DB09462GlycerinDNA mismatch repair protein MutLtarget
DB09462GlycerinGlycerol uptake facilitator proteintarget
DB09462GlycerinRibonucleoside-diphosphate reductase 1 subunit betatarget
DB09462GlycerinA/G-specific adenine glycosylasetarget
DB09462GlycerintRNA (cytosine(38)-C(5))-methyltransferasetarget
DB09462GlycerinCytochrome P450 2E1enzyme
DB09462GlycerinRetinal dehydrogenase 1enzyme
DB09462GlycerinPeroxisome proliferator-activated receptor deltatarget
DB09472Sodium sulfateCarbonic anhydrase 2target
DB09472Sodium sulfateCarbonic anhydrase 1target
DB09481Magnesium carbonateTransient receptor potential cation channel subfamily M member 6transporter
DB09481Magnesium carbonateSolute carrier family 41 member 3transporter
DB09481Magnesium carbonateMetal transporter CNNM2transporter
DB09481Magnesium carbonateTransient receptor potential cation channel subfamily M member 7transporter
DB09481Magnesium carbonateGlutamate (NMDA) receptortarget
DB11113Castor oilProstaglandin E2 receptor EP3 subtypetarget
DB11113Castor oilProstaglandin E2 receptor EP4 subtypetarget
DB11365SennosidesReverse transcriptase/RNaseHtarget
DB00653Magnesium sulfateVoltage-dependent calcium channel gamma-1 subunittarget
DB00653Magnesium sulfateVoltage-dependent calcium channel subunit alpha-2/delta-1target
DB00653Magnesium sulfateVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB00653Magnesium sulfateVoltage-dependent L-type calcium channel subunit beta-1target
DB00653Magnesium sulfateVoltage-dependent L-type calcium channel subunit beta-2target
DB00653Magnesium sulfateVoltage-dependent L-type calcium channel subunit alpha-1Starget
DB00742MannitolP-glycoprotein 1transporter
DB00742MannitolMannitol dehydrogenaseenzyme
DB01638SorbitolXylose isomerasetarget
DB01638SorbitolXylose isomerasetarget
DB01638SorbitolXylose isomerasetarget
DB01638SorbitolMalate synthase Gtarget
DB01183NaloxoneMu-type opioid receptortarget
DB01183NaloxoneEstrogen receptor alphatarget
DB01183NaloxoneCyclic AMP-responsive element-binding protein 1target
DB01183NaloxoneDelta-type opioid receptortarget
DB01183NaloxoneSolute carrier organic anion transporter family member 1A2transporter
DB01183NaloxoneP-glycoprotein 1transporter
DB01183NaloxoneKappa-type opioid receptortarget
DB01183NaloxoneCytochrome P450 3A4enzyme
DB01183NaloxoneSerum albumincarrier
DB01183NaloxoneToll-like receptor 4target
DB01183NaloxoneLiver carboxylesterase 1target
DB01183NaloxoneUDP-glucuronosyltransferase 1-1enzyme
DB11691NaldemedineCytochrome P450 3A Subfamilyenzyme
DB11691NaldemedineUDP-glucuronosyltransferase 1-3enzyme
DB11691NaldemedineMu-type opioid receptortarget
DB11691NaldemedineDelta-type opioid receptortarget
DB11691NaldemedineKappa-type opioid receptortarget
DB11691NaldemedineATP-binding cassette sub-family B member 5transporter
DB13170PlecanatideGuanylate cyclase soluble subunit alpha-2target