Antithrombin III human

Identification

Name
Antithrombin III human
Accession Number
DB11598
Type
Biotech
Groups
Approved
Biologic Classification
Protein Based Therapies
Thrombolytic agents
Description

A plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes. It is a member of the serpin superfamily.

Protein chemical formula
Not Available
Protein average weight
Not Available
Sequences
Not Available
Synonyms
  • Antithrombin III
  • Antithrombin III (human)
  • Antithrombin III human plasma-derived
  • Antithrombin III, human
  • Antithrombin III,human
  • AT-III
  • Heparin cofactor B
External IDs
ORG 10849
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Thrombate IIIKitGrifols1991-12-30Not applicableUs
Thrombate IIIPowder, for solution500 unitIntravenousGrifols Therapeutics Inc.Not applicableNot applicableCanada
Thrombate IIIPowder, for solution1000 unitIntravenousGrifols Therapeutics Inc.1996-11-11Not applicableCanada
Thrombate IIIKitGrifols1991-12-30Not applicableUs
Thrombate IIIKitGrifols1991-12-302017-06-29Us
Thrombate III Pws IV 1000iu/vialPowder, for solution1000 unitIntravenousMiles Inc. Pharmaceutical Division1995-12-311998-09-25Canada
Thrombate III Pws IV 500iu/vialPowder, for solution500 unitIntravenousMiles Inc. Pharmaceutical Division1995-12-311998-09-25Canada
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Antithrombin III ImmunoAntithrombin III human (1650 unit) + Water (30 ml)Powder, for solutionIntravenousBaxter Ag1999-07-052011-10-07Canada
Antithrombin III NfAntithrombin III human (550 unit) + Water (10 ml)Kit; Powder, for solutionIntravenousBaxalta Canada Corporation1999-07-05Not applicableCanada
Antithrombin III NfAntithrombin III human (1100 unit) + Water (20 ml)Kit; Powder, for solutionIntravenousBaxalta Canada Corporation1999-07-05Not applicableCanada
International/Other Brands
Thrombate III
Categories
UNII
T0LTO7L82X
CAS number
9000-94-6

Pharmacology

Indication

Antithrombin III human is a human antithrombin (AT) indicated in patients with hereditary antithrombin deficiency for the treatment and prevention of thromboembolism and prevention of peri-operative and peri-partum thromboembolism

Structured Indications
Pharmacodynamics

Hereditary AT deficiency causes an increased risk of venous thromboembolism (VTE). During high-risk situations such as surgery or trauma or for pregnant women, during the peri-partum period, the risk of development of VTEs as compared to the normal population in these situations is increased by a factor 10 to 50. In hereditary antithrombin deficient patients ATryn restores (normalize) plasma AT activity levels during peri-operative and peri-partum periods.

Mechanism of action

Antithrombin, an alpha2-glycoprotein of molecular weight 58,000, is normally present in human plasma at a concentration of approximately 12.5 mg/dL and is the major plasma inhibitor of thrombin. Inactivation of thrombin by AT occurs by formation of a covalent bond resulting in an inactive 1:1 stoichiometric complex between the two, involving an interaction of the active serine of thrombin and an arginine reactive site on AT. AT is also capable of inactivating other components of the coagulation cascade including factors IXa, Xa, XIa, and XIIa, as well as plasmin. The neutralization rate of serine proteases by AT proceeds slowly in the absence of heparin, but is greatly accelerated in the presence of heparin. As the therapeutic antithrombotic effect of heparin is mediated by AT, heparin in vivo is ineffective in the absence or near absence of AT. After administration, Antithrombin III human temporarily replaces the missing AT in patients with hereditary antithrombin deficiency.

TargetActionsOrganism
UAntithrombin-III
agonist
Human
Absorption

Therapeutic target plasma concentrations in patients with congenital antithrombin III deficiency range from 80–120% of values in healthy adults. At plasma concentrations ≤70% of normal, increased thrombin generation. Supraphysiologic plasma concentrations (e.g., 150–200% of normal) have increased bleeding risk in patients with sepsis and disseminated intravascular coagulation, not known whether supraphysiologic concentrations increase bleeding risk in patients with congenital antithrombin III deficiency.

Volume of distribution

Distributed into plasma (39%), extravascular space (49%), and vascular endothelial cells (11%).

Protein binding
Not Available
Metabolism

<5% metabolized to low molecular weight breakdown products.

Route of elimination

Complexes of antithrombin III with thrombin or other proteinases cleared principally by liver and excreted in urine.

Half life

2.5 - 3.8 hs

Clearance
Not Available
Toxicity
Not Available
Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
(4R)-limonene(4R)-limonene may increase the anticoagulant activities of Antithrombin III human.Investigational
AbacavirThe serum concentration of Abacavir can be decreased when it is combined with Antithrombin III human.Approved, Investigational
AbciximabAbciximab may increase the anticoagulant activities of Antithrombin III human.Approved
AceclofenacAceclofenac may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
AcemetacinThe risk or severity of bleeding can be increased when Antithrombin III human is combined with Acemetacin.Approved, Experimental, Investigational
AcenocoumarolAcenocoumarol may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
Acetylsalicylic acidAcetylsalicylic acid may increase the anticoagulant activities of Antithrombin III human.Approved, Vet Approved
AdapaleneAdapalene may increase the anticoagulant activities of Antithrombin III human.Approved
AlclofenacAlclofenac may increase the anticoagulant activities of Antithrombin III human.Approved, Withdrawn
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Antithrombin III human.Approved, Investigational
AllylestrenolThe therapeutic efficacy of Antithrombin III human can be decreased when used in combination with Allylestrenol.Approved
AlminoprofenAlminoprofen may increase the anticoagulant activities of Antithrombin III human.Experimental
AloxiprinAloxiprin may increase the anticoagulant activities of Antithrombin III human.Experimental
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Antithrombin III human.Approved, Illicit, Investigational
AlprostadilAlprostadil may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
AlteplaseAlteplase may increase the anticoagulant activities of Antithrombin III human.Approved
AltrenogestThe therapeutic efficacy of Antithrombin III human can be decreased when used in combination with Altrenogest.Vet Approved
Ambroxol acefyllinateThe serum concentration of Ambroxol acefyllinate can be decreased when it is combined with Antithrombin III human.Experimental, Investigational
AmineptineThe serum concentration of Amineptine can be increased when it is combined with Antithrombin III human.Illicit, Withdrawn
AminophyllineThe serum concentration of Aminophylline can be decreased when it is combined with Antithrombin III human.Approved
Aminosalicylic AcidAminosalicylic Acid may increase the anticoagulant activities of Antithrombin III human.Approved
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Antithrombin III human.Approved
AmoxapineThe serum concentration of Amoxapine can be increased when it is combined with Antithrombin III human.Approved
AnagrelideAnagrelide may increase the anticoagulant activities of Antithrombin III human.Approved
AncrodAncrod may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
AndrographolideAndrographolide may increase the anticoagulant activities of Antithrombin III human.Investigational
AnisodamineAnisodamine may increase the anticoagulant activities of Antithrombin III human.Investigational
AnistreplaseAnistreplase may increase the anticoagulant activities of Antithrombin III human.Approved
AntipyrineAntipyrine may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
ApixabanApixaban may increase the anticoagulant activities of Antithrombin III human.Approved
ApocyninApocynin may increase the anticoagulant activities of Antithrombin III human.Investigational
ApremilastApremilast may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
AprotininThe therapeutic efficacy of Antithrombin III human can be decreased when used in combination with Aprotinin.Approved, Investigational, Withdrawn
ArdeparinArdeparin may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational, Withdrawn
ArgatrobanArgatroban may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
AstaxanthinAstaxanthin may increase the anticoagulant activities of Antithrombin III human.Investigational
AzapropazoneAzapropazone may increase the anticoagulant activities of Antithrombin III human.Withdrawn
AzelastineAzelastine may increase the anticoagulant activities of Antithrombin III human.Approved
BalsalazideBalsalazide may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
BatroxobinBatroxobin may increase the anticoagulant activities of Antithrombin III human.Experimental
BecaplerminBecaplermin may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
BemiparinBemiparin may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
BendazacBendazac may increase the anticoagulant activities of Antithrombin III human.Experimental
BenorilateBenorilate may increase the anticoagulant activities of Antithrombin III human.Experimental
BenoxaprofenBenoxaprofen may increase the anticoagulant activities of Antithrombin III human.Withdrawn
BenzydamineBenzydamine may increase the anticoagulant activities of Antithrombin III human.Approved
BeraprostBeraprost may increase the anticoagulant activities of Antithrombin III human.Investigational
BevoniumBevonium may increase the anticoagulant activities of Antithrombin III human.Experimental
BivalirudinBivalirudin may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
BoceprevirThe serum concentration of Antithrombin III human can be decreased when it is combined with Boceprevir.Approved, Withdrawn
BrinaseBrinase may increase the anticoagulant activities of Antithrombin III human.Experimental
BromfenacBromfenac may increase the anticoagulant activities of Antithrombin III human.Approved
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Antithrombin III human.Approved, Investigational
BucillamineBucillamine may increase the anticoagulant activities of Antithrombin III human.Investigational
BufexamacBufexamac may increase the anticoagulant activities of Antithrombin III human.Approved, Experimental
BuflomedilBuflomedil may increase the anticoagulant activities of Antithrombin III human.Experimental
BumadizoneBumadizone may increase the anticoagulant activities of Antithrombin III human.Experimental
ButylphthalideButylphthalide may increase the anticoagulant activities of Antithrombin III human.Investigational
CabergolineThe serum concentration of Cabergoline can be increased when it is combined with Antithrombin III human.Approved
CangrelorCangrelor may increase the anticoagulant activities of Antithrombin III human.Approved
CaplacizumabCaplacizumab may increase the anticoagulant activities of Antithrombin III human.Investigational
CarbamazepineThe metabolism of Antithrombin III human can be increased when combined with Carbamazepine.Approved, Investigational
Carbaspirin calciumCarbaspirin calcium may increase the anticoagulant activities of Antithrombin III human.Experimental, Investigational
CarprofenCarprofen may increase the anticoagulant activities of Antithrombin III human.Approved, Vet Approved, Withdrawn
CastanospermineCastanospermine may increase the anticoagulant activities of Antithrombin III human.Experimental
CelecoxibCelecoxib may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
CertoparinCertoparin may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
ChloroquineChloroquine may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational, Vet Approved
ChlorotrianiseneThe serum concentration of Chlorotrianisene can be decreased when it is combined with Antithrombin III human.Investigational, Withdrawn
Choline magnesium trisalicylateCholine magnesium trisalicylate may increase the anticoagulant activities of Antithrombin III human.Approved
CilostazolCilostazol may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
Citric AcidCitric Acid may increase the anticoagulant activities of Antithrombin III human.Approved, Nutraceutical, Vet Approved
ClarithromycinThe therapeutic efficacy of Clarithromycin can be decreased when used in combination with Antithrombin III human.Approved
ClomipramineThe serum concentration of Clomipramine can be increased when it is combined with Antithrombin III human.Approved, Investigational, Vet Approved
ClonixinClonixin may increase the anticoagulant activities of Antithrombin III human.Approved
ClopidogrelClopidogrel may increase the anticoagulant activities of Antithrombin III human.Approved
CloricromenCloricromen may increase the anticoagulant activities of Antithrombin III human.Experimental
ClorindioneClorindione may increase the anticoagulant activities of Antithrombin III human.Experimental
Collagenase clostridium histolyticumThe risk or severity of adverse effects can be increased when Antithrombin III human is combined with Collagenase clostridium histolyticum.Approved, Investigational
Conjugated estrogensThe serum concentration of Conjugated estrogens can be decreased when it is combined with Antithrombin III human.Approved
CurcuminCurcumin may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be increased when it is combined with Antithrombin III human.Approved
CyclophosphamideThe risk or severity of adverse effects can be increased when Antithrombin III human is combined with Cyclophosphamide.Approved, Investigational
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Antithrombin III human.Approved, Investigational, Vet Approved
Dabigatran etexilateAntithrombin III human may increase the anticoagulant activities of Dabigatran etexilate.Approved
DaidzeinDaidzein may decrease the anticoagulant activities of Antithrombin III human.Experimental
DalteparinDalteparin may increase the anticoagulant activities of Antithrombin III human.Approved
DanaparoidDanaparoid may increase the anticoagulant activities of Antithrombin III human.Approved, Withdrawn
DarexabanAntithrombin III human may increase the anticoagulant activities of Darexaban.Investigational
DasatinibDasatinib may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
DeferasiroxThe risk or severity of adverse effects can be increased when Antithrombin III human is combined with Deferasirox.Approved, Investigational
DefibrotideDefibrotide may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
DelavirdineThe serum concentration of Delavirdine can be decreased when it is combined with Antithrombin III human.Approved
DemegestoneThe therapeutic efficacy of Antithrombin III human can be decreased when used in combination with Demegestone.Experimental
Deoxycholic AcidThe risk or severity of adverse effects can be increased when Antithrombin III human is combined with Deoxycholic Acid.Approved
DersalazineDersalazine may increase the anticoagulant activities of Antithrombin III human.Investigational
DesipramineThe serum concentration of Desipramine can be increased when it is combined with Antithrombin III human.Approved, Investigational
DesirudinDesirudin may increase the anticoagulant activities of Antithrombin III human.Approved
DesmoteplaseDesmoteplase may increase the anticoagulant activities of Antithrombin III human.Investigational
DesogestrelThe therapeutic efficacy of Antithrombin III human can be decreased when used in combination with Desogestrel.Approved
DextranDextran may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational, Vet Approved
Dextran 40Dextran 40 may increase the anticoagulant activities of Antithrombin III human.Approved
Dextran 70Dextran 70 may increase the anticoagulant activities of Antithrombin III human.Approved
Dextran 75Dextran 75 may increase the anticoagulant activities of Antithrombin III human.Approved
DibenzepinThe serum concentration of Dibenzepin can be increased when it is combined with Antithrombin III human.Experimental
DiclofenacDiclofenac may increase the anticoagulant activities of Antithrombin III human.Approved, Vet Approved
DicoumarolDicoumarol may increase the anticoagulant activities of Antithrombin III human.Approved
DienestrolThe serum concentration of Dienestrol can be decreased when it is combined with Antithrombin III human.Approved, Investigational
DienogestThe therapeutic efficacy of Antithrombin III human can be decreased when used in combination with Dienogest.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be decreased when it is combined with Antithrombin III human.Approved, Investigational
DifenpiramideDifenpiramide may increase the anticoagulant activities of Antithrombin III human.Experimental
DiflunisalDiflunisal may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Antithrombin III human.Approved
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Antithrombin III human.Approved, Investigational
DiltiazemThe metabolism of Diltiazem can be decreased when combined with Antithrombin III human.Approved, Investigational
DiphenadioneDiphenadione may increase the anticoagulant activities of Antithrombin III human.Experimental
DipyridamoleDipyridamole may increase the anticoagulant activities of Antithrombin III human.Approved
DitazoleDitazole may increase the anticoagulant activities of Antithrombin III human.Approved, Withdrawn
DosulepinThe serum concentration of Dosulepin can be increased when it is combined with Antithrombin III human.Approved
DoxepinThe serum concentration of Doxepin can be increased when it is combined with Antithrombin III human.Approved, Investigational
Drotrecogin alfaDrotrecogin alfa may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational, Withdrawn
DroxicamDroxicam may increase the anticoagulant activities of Antithrombin III human.Withdrawn
DuvelisibDuvelisib may increase the anticoagulant activities of Antithrombin III human.Investigational
DydrogesteroneThe therapeutic efficacy of Antithrombin III human can be decreased when used in combination with Dydrogesterone.Approved, Investigational, Withdrawn
DyphyllineThe serum concentration of Dyphylline can be decreased when it is combined with Antithrombin III human.Approved
E-6201E-6201 may increase the anticoagulant activities of Antithrombin III human.Investigational
Edetic AcidEdetic Acid may increase the anticoagulant activities of Antithrombin III human.Approved, Vet Approved
EdoxabanEdoxaban may increase the anticoagulant activities of Antithrombin III human.Approved
EnfuvirtideThe serum concentration of Enfuvirtide can be increased when it is combined with Antithrombin III human.Approved, Investigational
EnoxaparinEnoxaparin may increase the anticoagulant activities of Antithrombin III human.Approved
EpimestrolEpimestrol may decrease the anticoagulant activities of Antithrombin III human.Experimental
EpinastineEpinastine may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
EpirizoleEpirizole may increase the anticoagulant activities of Antithrombin III human.Approved
EplivanserinEplivanserin may increase the anticoagulant activities of Antithrombin III human.Investigational
eplivanserineeplivanserine may increase the anticoagulant activities of Antithrombin III human.Investigational
EpoprostenolEpoprostenol may increase the anticoagulant activities of Antithrombin III human.Approved
EptifibatideEptifibatide may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
EquolEquol may decrease the anticoagulant activities of Antithrombin III human.Investigational
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Antithrombin III human.Approved
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Antithrombin III human.Approved
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Antithrombin III human.Approved
EsmirtazapineThe serum concentration of Esmirtazapine can be increased when it is combined with Antithrombin III human.Investigational
EstradiolThe serum concentration of Estradiol can be decreased when it is combined with Antithrombin III human.Approved, Investigational, Vet Approved
Estradiol acetateEstradiol acetate may decrease the anticoagulant activities of Antithrombin III human.Approved, Investigational, Vet Approved
Estradiol cypionateEstradiol cypionate may decrease the anticoagulant activities of Antithrombin III human.Approved, Investigational, Vet Approved
Estradiol valerateEstradiol valerate may decrease the anticoagulant activities of Antithrombin III human.Approved, Investigational, Vet Approved
EstramustineThe serum concentration of Estramustine can be decreased when it is combined with Antithrombin III human.Approved, Investigational
EstriolEstriol may decrease the anticoagulant activities of Antithrombin III human.Approved, Investigational, Vet Approved
Estrogens, esterifiedThe serum concentration of Estrogens, esterified can be decreased when it is combined with Antithrombin III human.Approved
EstroneEstrone may decrease the anticoagulant activities of Antithrombin III human.Approved
Estrone sulfateThe serum concentration of Estrone sulfate can be decreased when it is combined with Antithrombin III human.Approved
EtanerceptEtanercept may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
EthenzamideEthenzamide may increase the anticoagulant activities of Antithrombin III human.Experimental
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Antithrombin III human.Approved
Ethyl biscoumacetateEthyl biscoumacetate may increase the anticoagulant activities of Antithrombin III human.Withdrawn
EtodolacEtodolac may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational, Vet Approved
EtofenamateEtofenamate may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
EtonogestrelThe therapeutic efficacy of Antithrombin III human can be decreased when used in combination with Etonogestrel.Approved, Investigational
EtoricoxibEtoricoxib may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
EtravirineThe serum concentration of Etravirine can be decreased when it is combined with Antithrombin III human.Approved
Evening primrose oilEvening primrose oil may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
ExisulindExisulind may increase the anticoagulant activities of Antithrombin III human.Investigational
FelbinacFelbinac may increase the anticoagulant activities of Antithrombin III human.Experimental
FenbufenFenbufen may increase the anticoagulant activities of Antithrombin III human.Approved
FenoprofenFenoprofen may increase the anticoagulant activities of Antithrombin III human.Approved
FentiazacFentiazac may increase the anticoagulant activities of Antithrombin III human.Experimental
FeprazoneFeprazone may increase the anticoagulant activities of Antithrombin III human.Experimental
Ferulic acidFerulic acid may increase the anticoagulant activities of Antithrombin III human.Experimental
FibrinolysinFibrinolysin may increase the anticoagulant activities of Antithrombin III human.Investigational
FloctafenineFloctafenine may increase the anticoagulant activities of Antithrombin III human.Approved, Withdrawn
FluindioneAntithrombin III human may increase the anticoagulant activities of Fluindione.Approved, Investigational
FlunixinFlunixin may increase the anticoagulant activities of Antithrombin III human.Vet Approved
FlunoxaprofenFlunoxaprofen may increase the anticoagulant activities of Antithrombin III human.Experimental
FlurbiprofenFlurbiprofen may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
FondaparinuxAntithrombin III human may increase the anticoagulant activities of Fondaparinux.Approved, Investigational
Fondaparinux sodiumFondaparinux sodium may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
GabexateAntithrombin III human may increase the anticoagulant activities of Gabexate.Investigational
GarlicThe serum concentration of Antithrombin III human can be decreased when it is combined with Garlic.Approved
GenisteinGenistein may decrease the anticoagulant activities of Antithrombin III human.Investigational
GestodeneThe therapeutic efficacy of Antithrombin III human can be decreased when used in combination with Gestodene.Approved, Investigational
GestonoroneThe therapeutic efficacy of Antithrombin III human can be decreased when used in combination with Gestonorone.Experimental
GestrinoneThe therapeutic efficacy of Antithrombin III human can be decreased when used in combination with Gestrinone.Approved
GuacetisalGuacetisal may increase the anticoagulant activities of Antithrombin III human.Experimental
HeminHemin may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
Hemoglobin crosfumarilHemoglobin crosfumaril may increase the anticoagulant activities of Antithrombin III human.Experimental
HeparinHeparin may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
HexestrolThe serum concentration of Hexestrol can be decreased when it is combined with Antithrombin III human.Withdrawn
HigenamineHigenamine may increase the anticoagulant activities of Antithrombin III human.Investigational
Hydroxyprogesterone caproateThe therapeutic efficacy of Antithrombin III human can be decreased when used in combination with Hydroxyprogesterone caproate.Approved, Investigational
HydroxytyrosolHydroxytyrosol may increase the anticoagulant activities of Antithrombin III human.Investigational
Ibritumomab tiuxetanThe risk or severity of adverse effects can be increased when Antithrombin III human is combined with Ibritumomab tiuxetan.Approved, Investigational
IbrutinibThe risk or severity of adverse effects can be increased when Ibrutinib is combined with Antithrombin III human.Approved
IbudilastIbudilast may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
IbuprofenIbuprofen may increase the anticoagulant activities of Antithrombin III human.Approved
IbuproxamIbuproxam may increase the anticoagulant activities of Antithrombin III human.Withdrawn
IcatibantIcatibant may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
Icosapent ethylIcosapent ethyl may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational, Nutraceutical
IdraparinuxIdraparinux may increase the anticoagulant activities of Antithrombin III human.Investigational
IfenprodilIfenprodil may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational, Withdrawn
IfetrobanIfetroban may increase the anticoagulant activities of Antithrombin III human.Investigational
IloprostIloprost may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
Imidazole salicylateImidazole salicylate may increase the anticoagulant activities of Antithrombin III human.Experimental
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Antithrombin III human.Approved
IndobufenIndobufen may increase the anticoagulant activities of Antithrombin III human.Investigational
IndomethacinIndomethacin may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
IndoprofenIndoprofen may increase the anticoagulant activities of Antithrombin III human.Withdrawn
IprindoleThe serum concentration of Iprindole can be increased when it is combined with Antithrombin III human.Experimental
IsoxicamIsoxicam may increase the anticoagulant activities of Antithrombin III human.Withdrawn
KebuzoneKebuzone may increase the anticoagulant activities of Antithrombin III human.Experimental
KetanserinKetanserin may increase the anticoagulant activities of Antithrombin III human.Investigational
KetoprofenKetoprofen may increase the anticoagulant activities of Antithrombin III human.Approved, Vet Approved
KetorolacKetorolac may increase the anticoagulant activities of Antithrombin III human.Approved
LeflunomideLeflunomide may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
LepirudinLepirudin may increase the anticoagulant activities of Antithrombin III human.Approved
LetaxabanAntithrombin III human may increase the anticoagulant activities of Letaxaban.Investigational
LevonorgestrelThe therapeutic efficacy of Antithrombin III human can be decreased when used in combination with Levonorgestrel.Approved, Investigational
LimaprostThe risk or severity of adverse effects can be increased when Limaprost is combined with Antithrombin III human.Approved, Investigational
LinsidomineLinsidomine may increase the anticoagulant activities of Antithrombin III human.Experimental
LisofyllineLisofylline may increase the anticoagulant activities of Antithrombin III human.Investigational
LofepramineThe serum concentration of Lofepramine can be increased when it is combined with Antithrombin III human.Experimental
LonazolacLonazolac may increase the anticoagulant activities of Antithrombin III human.Experimental
LornoxicamLornoxicam may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Antithrombin III human.Approved, Investigational
LoxoprofenLoxoprofen may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
LumiracoxibLumiracoxib may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
Magnesium salicylateMagnesium salicylate may increase the anticoagulant activities of Antithrombin III human.Approved
MasoprocolMasoprocol may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
Meclofenamic acidMeclofenamic acid may increase the anticoagulant activities of Antithrombin III human.Approved, Vet Approved
MedrogestoneThe therapeutic efficacy of Antithrombin III human can be decreased when used in combination with Medrogestone.Approved
Medroxyprogesterone acetateThe therapeutic efficacy of Antithrombin III human can be decreased when used in combination with Medroxyprogesterone acetate.Approved, Investigational
Mefenamic acidMefenamic acid may increase the anticoagulant activities of Antithrombin III human.Approved
Megestrol acetateThe therapeutic efficacy of Antithrombin III human can be decreased when used in combination with Megestrol acetate.Approved, Investigational, Vet Approved
MelagatranAntithrombin III human may increase the anticoagulant activities of Melagatran.Experimental
MeloxicamMeloxicam may increase the anticoagulant activities of Antithrombin III human.Approved, Vet Approved
MesalazineMesalazine may increase the anticoagulant activities of Antithrombin III human.Approved
MestranolThe serum concentration of Mestranol can be decreased when it is combined with Antithrombin III human.Approved
MetamizoleMetamizole may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational, Withdrawn
MethallenestrilThe serum concentration of Methallenestril can be decreased when it is combined with Antithrombin III human.Experimental
Methyl salicylateMethyl salicylate may increase the anticoagulant activities of Antithrombin III human.Approved, Vet Approved
MethylergometrineThe serum concentration of Methylergometrine can be increased when it is combined with Antithrombin III human.Approved
MethylestrenoloneThe therapeutic efficacy of Antithrombin III human can be decreased when used in combination with Methylestrenolone.Experimental
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Antithrombin III human.Approved, Illicit
MilrinoneMilrinone may increase the anticoagulant activities of Antithrombin III human.Approved
MirtazapineThe serum concentration of Mirtazapine can be increased when it is combined with Antithrombin III human.Approved
MizoribineMizoribine may increase the anticoagulant activities of Antithrombin III human.Investigational
MofebutazoneMofebutazone may increase the anticoagulant activities of Antithrombin III human.Experimental
MoxestrolMoxestrol may decrease the anticoagulant activities of Antithrombin III human.Experimental
Mycophenolate mofetilMycophenolate mofetil may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
Mycophenolic acidMycophenolic acid may increase the anticoagulant activities of Antithrombin III human.Approved
NabumetoneNabumetone may increase the anticoagulant activities of Antithrombin III human.Approved
NadroparinNadroparin may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
NafamostatNafamostat may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
NaftifineNaftifine may increase the anticoagulant activities of Antithrombin III human.Approved
NaftopidilNaftopidil may increase the anticoagulant activities of Antithrombin III human.Investigational
NaproxenNaproxen may increase the anticoagulant activities of Antithrombin III human.Approved, Vet Approved
NefazodoneThe serum concentration of Nefazodone can be increased when it is combined with Antithrombin III human.Approved, Withdrawn
NepafenacNepafenac may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
NifenazoneNifenazone may increase the anticoagulant activities of Antithrombin III human.Experimental
Niflumic AcidNiflumic Acid may increase the anticoagulant activities of Antithrombin III human.Approved
NimesulideNimesulide may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational, Withdrawn
NintedanibThe risk or severity of adverse effects can be increased when Antithrombin III human is combined with Nintedanib.Approved
NitroaspirinNitroaspirin may increase the anticoagulant activities of Antithrombin III human.Investigational
NomegestrolThe therapeutic efficacy of Antithrombin III human can be decreased when used in combination with Nomegestrol.Approved
NorethisteroneThe therapeutic efficacy of Antithrombin III human can be decreased when used in combination with Norethisterone.Approved
NorgestrienoneThe therapeutic efficacy of Antithrombin III human can be decreased when used in combination with Norgestrienone.Experimental
NortriptylineThe serum concentration of Nortriptyline can be increased when it is combined with Antithrombin III human.Approved
ObinutuzumabThe risk or severity of adverse effects can be increased when Antithrombin III human is combined with Obinutuzumab.Approved, Investigational
OlopatadineOlopatadine may increase the anticoagulant activities of Antithrombin III human.Approved
OlsalazineOlsalazine may increase the anticoagulant activities of Antithrombin III human.Approved
Omacetaxine mepesuccinateThe risk or severity of bleeding can be increased when Antithrombin III human is combined with Omacetaxine mepesuccinate.Approved, Investigational
Omega-3 fatty acidsOmega-3 fatty acids may increase the anticoagulant activities of Antithrombin III human.Approved, Nutraceutical
OpipramolThe serum concentration of Opipramol can be increased when it is combined with Antithrombin III human.Investigational
OrgoteinOrgotein may increase the anticoagulant activities of Antithrombin III human.Vet Approved
OtamixabanOtamixaban may increase the anticoagulant activities of Antithrombin III human.Investigational
OxaprozinOxaprozin may increase the anticoagulant activities of Antithrombin III human.Approved
OxyphenbutazoneOxyphenbutazone may increase the anticoagulant activities of Antithrombin III human.Approved, Withdrawn
OzagrelOzagrel may increase the anticoagulant activities of Antithrombin III human.Investigational
ParecoxibParecoxib may increase the anticoagulant activities of Antithrombin III human.Approved
ParnaparinParnaparin may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
ParthenolideParthenolide may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
Pentaerythritol TetranitratePentaerythritol Tetranitrate may increase the anticoagulant activities of Antithrombin III human.Approved
Pentosan PolysulfatePentosan Polysulfate may increase the anticoagulant activities of Antithrombin III human.Approved
PentoxifyllinePentoxifylline may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
PethidineThe risk or severity of adverse effects can be increased when Antithrombin III human is combined with Pethidine.Approved
PhenindionePhenindione may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
PhenprocoumonPhenprocoumon may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
PhenylbutazonePhenylbutazone may increase the anticoagulant activities of Antithrombin III human.Approved, Vet Approved
PicotamidePicotamide may increase the anticoagulant activities of Antithrombin III human.Experimental
PimecrolimusPimecrolimus may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
PirfenidonePirfenidone may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
PiroxicamPiroxicam may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
PirprofenPirprofen may increase the anticoagulant activities of Antithrombin III human.Experimental
Polyestradiol phosphatePolyestradiol phosphate may decrease the anticoagulant activities of Antithrombin III human.Approved
PranoprofenPranoprofen may increase the anticoagulant activities of Antithrombin III human.Experimental, Investigational
PrasugrelPrasugrel may increase the anticoagulant activities of Antithrombin III human.Approved
ProgesteroneThe therapeutic efficacy of Antithrombin III human can be decreased when used in combination with Progesterone.Approved, Vet Approved
ProglumetacinProglumetacin may increase the anticoagulant activities of Antithrombin III human.Experimental
PromegestoneThe therapeutic efficacy of Antithrombin III human can be decreased when used in combination with Promegestone.Experimental
PromestrienePromestriene may decrease the anticoagulant activities of Antithrombin III human.Investigational
PropacetamolPropacetamol may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
PropyphenazonePropyphenazone may increase the anticoagulant activities of Antithrombin III human.Experimental
ProquazoneProquazone may increase the anticoagulant activities of Antithrombin III human.Experimental
Protein CProtein C may increase the anticoagulant activities of Antithrombin III human.Approved
Protein S humanAntithrombin III human may increase the anticoagulant activities of Protein S human.Approved
ProtocatechualdehydeProtocatechualdehyde may increase the anticoagulant activities of Antithrombin III human.Approved
ProtriptylineThe serum concentration of Protriptyline can be increased when it is combined with Antithrombin III human.Approved
PTC299PTC299 may increase the anticoagulant activities of Antithrombin III human.Investigational
QuinestrolQuinestrol may decrease the anticoagulant activities of Antithrombin III human.Approved
RamatrobanRamatroban may increase the anticoagulant activities of Antithrombin III human.Investigational
RelcovaptanRelcovaptan may increase the anticoagulant activities of Antithrombin III human.Investigational
ResveratrolResveratrol may increase the anticoagulant activities of Antithrombin III human.Approved, Experimental, Investigational
ReteplaseReteplase may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
ReviparinReviparin may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
RidogrelRidogrel may increase the anticoagulant activities of Antithrombin III human.Approved
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Antithrombin III human.Approved
RivaroxabanAntithrombin III human may increase the anticoagulant activities of Rivaroxaban.Approved
RofecoxibRofecoxib may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational, Withdrawn
RosiglitazoneRosiglitazone may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
SalicylamideSalicylamide may increase the anticoagulant activities of Antithrombin III human.Approved
Salicylic acidSalicylic acid may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational, Vet Approved
SalsalateSalsalate may increase the anticoagulant activities of Antithrombin III human.Approved
SarpogrelateSarpogrelate may increase the anticoagulant activities of Antithrombin III human.Investigational
SaruplaseSaruplase may increase the anticoagulant activities of Antithrombin III human.Experimental
SecoisolariciresinolSecoisolariciresinol may decrease the anticoagulant activities of Antithrombin III human.Investigational
SelexipagSelexipag may increase the anticoagulant activities of Antithrombin III human.Approved
SemapimodSemapimod may increase the anticoagulant activities of Antithrombin III human.Investigational
SeratrodastSeratrodast may increase the anticoagulant activities of Antithrombin III human.Approved
SerrapeptaseSerrapeptase may increase the anticoagulant activities of Antithrombin III human.Investigational
SevofluraneSevoflurane may increase the anticoagulant activities of Antithrombin III human.Approved, Vet Approved
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Antithrombin III human.Approved, Investigational
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Antithrombin III human.Approved
SRT501SRT501 may increase the anticoagulant activities of Antithrombin III human.Investigational
St. John's WortThe metabolism of Antithrombin III human can be increased when combined with St. John's Wort.Approved, Investigational, Nutraceutical
StreptokinaseStreptokinase may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
SugammadexSugammadex may increase the anticoagulant activities of Antithrombin III human.Approved
SulfasalazineSulfasalazine may increase the anticoagulant activities of Antithrombin III human.Approved
SulindacSulindac may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
SulodexideSulodexide may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
SuprofenSuprofen may increase the anticoagulant activities of Antithrombin III human.Approved, Withdrawn
SuxibuzoneSuxibuzone may increase the anticoagulant activities of Antithrombin III human.Experimental
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be decreased when it is combined with Antithrombin III human.Approved
Synthetic Conjugated Estrogens, BSynthetic Conjugated Estrogens, B may decrease the anticoagulant activities of Antithrombin III human.Approved
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Antithrombin III human.Approved, Investigational
TarenflurbilTarenflurbil may increase the anticoagulant activities of Antithrombin III human.Investigational
TemsirolimusThe risk or severity of adverse effects can be increased when Antithrombin III human is combined with Temsirolimus.Approved
TenecteplaseTenecteplase may increase the anticoagulant activities of Antithrombin III human.Approved
TenidapTenidap may increase the anticoagulant activities of Antithrombin III human.Experimental
TenoxicamTenoxicam may increase the anticoagulant activities of Antithrombin III human.Approved
TepoxalinTepoxalin may increase the anticoagulant activities of Antithrombin III human.Vet Approved
TeriflunomideTeriflunomide may increase the anticoagulant activities of Antithrombin III human.Approved
TesmilifeneTesmilifene may increase the anticoagulant activities of Antithrombin III human.Investigational
Testosterone cypionateThe therapeutic efficacy of Antithrombin III human can be increased when used in combination with Testosterone cypionate.Approved
Testosterone enanthateThe therapeutic efficacy of Antithrombin III human can be increased when used in combination with Testosterone enanthate.Approved
Testosterone undecanoateThe therapeutic efficacy of Antithrombin III human can be increased when used in combination with Testosterone undecanoate.Approved, Investigational
TheophyllineThe serum concentration of Theophylline can be decreased when it is combined with Antithrombin III human.Approved
TianeptineThe serum concentration of Tianeptine can be increased when it is combined with Antithrombin III human.Approved, Investigational
Tiaprofenic acidTiaprofenic acid may increase the anticoagulant activities of Antithrombin III human.Approved
TiboloneTibolone may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
TicagrelorTicagrelor may increase the anticoagulant activities of Antithrombin III human.Approved
TiclopidineTiclopidine may increase the anticoagulant activities of Antithrombin III human.Approved
TinoridineTinoridine may increase the anticoagulant activities of Antithrombin III human.Investigational
TinzaparinTinzaparin may increase the anticoagulant activities of Antithrombin III human.Approved
TioclomarolTioclomarol may increase the anticoagulant activities of Antithrombin III human.Experimental
TipranavirTipranavir may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
TirofibanTirofiban may increase the anticoagulant activities of Antithrombin III human.Approved
Tolfenamic AcidTolfenamic Acid may increase the anticoagulant activities of Antithrombin III human.Approved
TolmetinTolmetin may increase the anticoagulant activities of Antithrombin III human.Approved
TositumomabThe risk or severity of adverse effects can be increased when Antithrombin III human is combined with Tositumomab.Approved, Investigational
TranilastTranilast may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
TrapidilTrapidil may increase the anticoagulant activities of Antithrombin III human.Approved
TreprostinilTreprostinil may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Antithrombin III human.Approved, Investigational
TribenosideTribenoside may increase the anticoagulant activities of Antithrombin III human.Experimental
TriflusalTriflusal may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
TrimipramineThe serum concentration of Trimipramine can be increased when it is combined with Antithrombin III human.Approved
TriptolideTriptolide may increase the anticoagulant activities of Antithrombin III human.Investigational
Trolamine salicylateTrolamine salicylate may increase the anticoagulant activities of Antithrombin III human.Approved
TroxerutinAntithrombin III human may increase the anticoagulant activities of Troxerutin.Investigational
UrokinaseUrokinase may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational, Withdrawn
ValdecoxibValdecoxib may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational, Withdrawn
Valproic AcidThe serum concentration of Valproic Acid can be decreased when it is combined with Antithrombin III human.Approved, Investigational
VerapamilThe metabolism of Verapamil can be decreased when combined with Antithrombin III human.Approved
Vitamin EVitamin E may increase the anticoagulant activities of Antithrombin III human.Approved, Nutraceutical, Vet Approved
VorapaxarThe risk or severity of adverse effects can be increased when Vorapaxar is combined with Antithrombin III human.Approved
WarfarinWarfarin may increase the anticoagulant activities of Antithrombin III human.Approved
XimelagatranXimelagatran may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational, Withdrawn
ZaltoprofenZaltoprofen may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational
ZeranolZeranol may decrease the anticoagulant activities of Antithrombin III human.Vet Approved
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Antithrombin III human.Approved
ZileutonZileuton may increase the anticoagulant activities of Antithrombin III human.Approved, Investigational, Withdrawn
ZomepiracZomepirac may increase the anticoagulant activities of Antithrombin III human.Withdrawn
Food Interactions
Not Available

References

General References
  1. Cavenagh JD, Colvin BT: Guidelines for the management of thrombophilia. Department of Haematology, The Royal London Hospital, Whitechapel, London, UK. Postgrad Med J. 1996 Feb;72(844):87-94. [PubMed:8871458]
  2. Menache D, Grossman BJ, Jackson CM: Antithrombin III: physiology, deficiency, and replacement therapy. Transfusion. 1992 Jul-Aug;32(6):580-8. [PubMed:1502714]
  3. Aibiki M, Fukuoka N, Nishiyama T, Maekawa S, Shirakawa Y: Differences in antithrombin III activities by administration method in critical patients with disseminated intravascular coagulation: a pharmacokinetic study. Shock. 2007 Aug;28(2):141-7. [PubMed:17515857]
  4. Collen D, Schetz J, de Cock F, Holmer E, Verstraete M: Metabolism of antithrombin III (heparin cofactor) in man: effects of venous thrombosis and of heparin administration. Eur J Clin Invest. 1977 Feb;7(1):27-35. [PubMed:65284]
  5. FDA label [Link]
External Links
PubChem Substance
347911209
ATC Codes
B01AB02 — Antithrombin iii
AHFS Codes
  • 20:12.04.12 — Direct Thrombin Inhibitors

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1RecruitingTreatmentCardiopulmonary Bypass / Extracorporeal Membrane Oxygenation Complication1
1TerminatedTreatmentCongenital Heart Disease (CHD)1
2CompletedPreventionAcquired Antithrombin III Deficiency / Coronary Artery Bypass Graft1
2CompletedTreatmentATIII Deficiency1
2RecruitingTreatmentCardiopulmonary Bypass / Surgery, Cardiac1
2, 3RecruitingPreventionHereditary antithrombin III deficiency1
3CompletedTreatmentCardiopulmonary Bypass1
4Unknown StatusSupportive CareAcute Coronary Syndromes (ACS) / Aortic Valve Insufficiency / Aortic Valve Stenosis / Mitral Valve Insufficiency / Mitral Valve Stenosis1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
Powder, for solutionIntravenous
Kit; powder, for solutionIntravenous
Kit
Powder, for solutionIntravenous1000 unit
Powder, for solutionIntravenous500 unit
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available

Taxonomy

Description
Not Available
Kingdom
Organic Compounds
Super Class
Organic Acids
Class
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Peptides
Alternative Parents
Not Available
Substituents
Not Available
Molecular Framework
Not Available
External Descriptors
Not Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Agonist
General Function
Serine-type endopeptidase inhibitor activity
Specific Function
Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory a...
Gene Name
SERPINC1
Uniprot ID
P01008
Uniprot Name
Antithrombin-III
Molecular Weight
52601.935 Da
References
  1. Menache D, Grossman BJ, Jackson CM: Antithrombin III: physiology, deficiency, and replacement therapy. Transfusion. 1992 Jul-Aug;32(6):580-8. [PubMed:1502714]

Drug created on May 20, 2016 14:36 / Updated on February 13, 2018 09:54