Gepirone

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Gepirone
Accession Number
DB12184
Type
Small Molecule
Groups
Investigational
Description

Gepirone has been used in trials studying the treatment of Cocaine-Related Disorders.

Structure
Thumb
Synonyms
Not Available
Product Ingredients
IngredientUNIICASInChI Key
Gepirone Hydrochloride80C9L8EP6V83928-66-9DGOCVISYYYQFEP-UHFFFAOYSA-N
Categories
UNII
JW5Y7B8Z18
CAS number
83928-76-1
Weight
Average: 359.474
Monoisotopic: 359.232125194
Chemical Formula
C19H29N5O2
InChI Key
QOIGKGMMAGJZNZ-UHFFFAOYSA-N
InChI
InChI=1S/C19H29N5O2/c1-19(2)14-16(25)24(17(26)15-19)9-4-3-8-22-10-12-23(13-11-22)18-20-6-5-7-21-18/h5-7H,3-4,8-15H2,1-2H3
IUPAC Name
4,4-dimethyl-1-{4-[4-(pyrimidin-2-yl)piperazin-1-yl]butyl}piperidine-2,6-dione
SMILES
CC1(C)CC(=O)N(CCCCN2CCN(CC2)C2=NC=CC=N2)C(=O)C1

Pharmacology

Indication
Not Available
Structured Indications
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
7-NitroindazoleThe risk or severity of adverse effects can be increased when 7-Nitroindazole is combined with Gepirone.Experimental
AcepromazineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Gepirone.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Gepirone.Approved
AdipiplonThe risk or severity of adverse effects can be increased when Adipiplon is combined with Gepirone.Investigational
AgomelatineThe risk or severity of adverse effects can be increased when Agomelatine is combined with Gepirone.Approved, Investigational
AlaproclateThe risk or severity of adverse effects can be increased when Gepirone is combined with Alaproclate.Experimental
AlfaxaloneThe risk or severity of adverse effects can be increased when Alfaxalone is combined with Gepirone.Vet Approved
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Gepirone.Approved, Illicit
AllopregnanoloneThe risk or severity of adverse effects can be increased when Allopregnanolone is combined with Gepirone.Investigational
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Gepirone.Experimental, Illicit
AlphaprodineThe risk or severity of adverse effects can be increased when Gepirone is combined with Alphaprodine.Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Gepirone.Approved, Illicit, Investigational
AmisulprideThe risk or severity of adverse effects can be increased when Amisulpride is combined with Gepirone.Approved, Investigational
AmitriptylineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Gepirone.Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Gepirone.Approved, Illicit
AmoxapineThe risk or severity of adverse effects can be increased when Amoxapine is combined with Gepirone.Approved
AmperozideThe risk or severity of adverse effects can be increased when Amperozide is combined with Gepirone.Experimental
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Gepirone.Approved, Investigational
ArticaineThe risk or severity of adverse effects can be increased when Articaine is combined with Gepirone.Approved
AsenapineThe risk or severity of adverse effects can be increased when Asenapine is combined with Gepirone.Approved
AzaperoneThe risk or severity of adverse effects can be increased when Azaperone is combined with Gepirone.Investigational, Vet Approved
AzelastineGepirone may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Gepirone.Approved
BarbitalThe risk or severity of adverse effects can be increased when Barbital is combined with Gepirone.Illicit
BenperidolThe risk or severity of adverse effects can be increased when Gepirone is combined with Benperidol.Approved, Investigational
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Gepirone.Approved, Investigational
Benzyl alcoholThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Gepirone.Approved
BrexpiprazoleThe risk or severity of adverse effects can be increased when Brexpiprazole is combined with Gepirone.Approved, Investigational
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Gepirone.Approved
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Gepirone.Approved, Illicit, Investigational
BromisovalThe risk or severity of adverse effects can be increased when Gepirone is combined with Bromisoval.Experimental
BromperidolThe risk or severity of adverse effects can be increased when Gepirone is combined with Bromperidol.Approved, Investigational
BrompheniramineThe risk or severity of adverse effects can be increased when Brompheniramine is combined with Gepirone.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Brotizolam is combined with Gepirone.Approved, Investigational, Withdrawn
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Gepirone.Approved, Investigational
BuprenorphineGepirone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Gepirone.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Gepirone.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Butacaine is combined with Gepirone.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Butalbital is combined with Gepirone.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Butamben is combined with Gepirone.Approved
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Gepirone.Approved, Illicit
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Gepirone.Approved, Illicit, Vet Approved
CanertinibThe risk or severity of adverse effects can be increased when Canertinib is combined with Gepirone.Investigational
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Gepirone.Approved, Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when Carbinoxamine is combined with Gepirone.Approved
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Gepirone.Illicit, Investigational, Vet Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Carisoprodol is combined with Gepirone.Approved
CetirizineThe risk or severity of adverse effects can be increased when Cetirizine is combined with Gepirone.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Gepirone.Approved, Illicit, Investigational, Vet Approved
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Gepirone.Approved, Illicit, Investigational
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Gepirone.Approved, Investigational, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Gepirone.Approved
ChlorphenamineThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Gepirone.Approved
ChlorpromazineThe risk or severity of adverse effects can be increased when Chlorpromazine is combined with Gepirone.Approved, Investigational, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Gepirone.Approved, Investigational, Withdrawn
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Gepirone.Approved
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Gepirone.Approved, Vet Approved
CitalopramThe risk or severity of adverse effects can be increased when Gepirone is combined with Citalopram.Approved
ClemastineThe risk or severity of adverse effects can be increased when Clemastine is combined with Gepirone.Approved, Investigational
ClidiniumThe risk or severity of adverse effects can be increased when Clidinium is combined with Gepirone.Approved
ClobazamThe risk or severity of adverse effects can be increased when Clobazam is combined with Gepirone.Approved, Illicit
clomethiazoleThe risk or severity of adverse effects can be increased when clomethiazole is combined with Gepirone.Investigational
ClomipramineThe risk or severity of adverse effects can be increased when Clomipramine is combined with Gepirone.Approved, Investigational, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when Clonazepam is combined with Gepirone.Approved, Illicit
ClonidineThe risk or severity of adverse effects can be increased when Clonidine is combined with Gepirone.Approved
ClopenthixolThe risk or severity of adverse effects can be increased when Gepirone is combined with Clopenthixol.Experimental
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Gepirone.Approved, Illicit
ClothiapineThe risk or severity of adverse effects can be increased when Gepirone is combined with Clothiapine.Experimental
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Gepirone.Approved
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Gepirone.Approved, Illicit
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Gepirone.Approved, Illicit
CyclizineThe risk or severity of adverse effects can be increased when Cyclizine is combined with Gepirone.Approved
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Gepirone.Approved
CyclopropaneThe risk or severity of adverse effects can be increased when Gepirone is combined with Cyclopropane.Experimental
CyproheptadineThe risk or severity of adverse effects can be increased when Cyproheptadine is combined with Gepirone.Approved
DantroleneThe risk or severity of adverse effects can be increased when Dantrolene is combined with Gepirone.Approved, Investigational
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Gepirone.Approved
DapoxetineThe risk or severity of adverse effects can be increased when Gepirone is combined with Dapoxetine.Investigational
DeramciclaneThe risk or severity of adverse effects can be increased when Deramciclane is combined with Gepirone.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Gepirone.Approved
DesipramineThe risk or severity of adverse effects can be increased when Desipramine is combined with Gepirone.Approved, Investigational
DesloratadineThe risk or severity of adverse effects can be increased when Desloratadine is combined with Gepirone.Approved, Investigational
DesvenlafaxineThe risk or severity of adverse effects can be increased when Gepirone is combined with Desvenlafaxine.Approved, Investigational
DetomidineThe risk or severity of adverse effects can be increased when Detomidine is combined with Gepirone.Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Gepirone.Approved
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Gepirone.Approved, Vet Approved
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Gepirone.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Gepirone.Approved, Illicit, Investigational, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Gepirone.Approved, Investigational
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Gepirone.Approved, Illicit, Investigational, Vet Approved
Diethyl etherThe risk or severity of adverse effects can be increased when Gepirone is combined with Diethyl ether.Experimental
DifenoxinThe risk or severity of adverse effects can be increased when Difenoxin is combined with Gepirone.Approved, Illicit
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Gepirone.Approved, Illicit
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Gepirone.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Dihydromorphine is combined with Gepirone.Experimental, Illicit
DimenhydrinateThe risk or severity of adverse effects can be increased when Dimenhydrinate is combined with Gepirone.Approved
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Gepirone.Approved, Investigational
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Gepirone.Approved, Illicit
DixyrazineThe risk or severity of adverse effects can be increased when Gepirone is combined with Dixyrazine.Experimental
DoramectinThe risk or severity of adverse effects can be increased when Doramectin is combined with Gepirone.Vet Approved
DoxepinThe risk or severity of adverse effects can be increased when Doxepin is combined with Gepirone.Approved, Investigational
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Gepirone.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when DPDPE is combined with Gepirone.Experimental
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Gepirone.Approved, Illicit
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Gepirone.Approved, Vet Approved
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Gepirone.Experimental, Illicit
DuloxetineThe risk or severity of adverse effects can be increased when Gepirone is combined with Duloxetine.Approved
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Gepirone.Approved
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Gepirone.Experimental, Illicit
EcopipamThe risk or severity of adverse effects can be increased when Gepirone is combined with Ecopipam.Investigational
EfavirenzThe risk or severity of adverse effects can be increased when Efavirenz is combined with Gepirone.Approved, Investigational
EltanoloneThe risk or severity of adverse effects can be increased when Gepirone is combined with Eltanolone.Investigational
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Gepirone.Approved, Investigational, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Entacapone is combined with Gepirone.Approved, Investigational
EscitalopramThe risk or severity of adverse effects can be increased when Gepirone is combined with Escitalopram.Approved, Investigational
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Gepirone.Approved, Illicit
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Gepirone.Approved, Investigational
EthanolGepirone may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Gepirone.Approved, Illicit, Withdrawn
EthosuximideThe risk or severity of adverse effects can be increased when Ethosuximide is combined with Gepirone.Approved
EthotoinThe risk or severity of adverse effects can be increased when Ethotoin is combined with Gepirone.Approved
Ethyl carbamateThe risk or severity of adverse effects can be increased when Ethyl carbamate is combined with Gepirone.Withdrawn
Ethyl chlorideThe risk or severity of adverse effects can be increased when Gepirone is combined with Ethyl chloride.Approved, Experimental, Investigational
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Gepirone.Approved, Illicit
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Gepirone.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Etidocaine is combined with Gepirone.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Gepirone.Investigational, Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Etizolam is combined with Gepirone.Approved
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Gepirone.Approved
EtoperidoneThe risk or severity of adverse effects can be increased when Gepirone is combined with Etoperidone.Withdrawn
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Gepirone.Illicit, Vet Approved
EzogabineThe risk or severity of adverse effects can be increased when Ezogabine is combined with Gepirone.Approved, Investigational
FelbamateThe risk or severity of adverse effects can be increased when Felbamate is combined with Gepirone.Approved
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Gepirone.Approved, Illicit, Withdrawn
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Gepirone.Approved, Illicit, Investigational, Vet Approved
FexofenadineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Gepirone.Approved, Investigational
FlibanserinThe risk or severity of adverse effects can be increased when Flibanserin is combined with Gepirone.Approved, Investigational
FluanisoneThe risk or severity of adverse effects can be increased when Gepirone is combined with Fluanisone.Experimental
FludiazepamThe risk or severity of adverse effects can be increased when Fludiazepam is combined with Gepirone.Approved, Illicit
FlunarizineThe risk or severity of adverse effects can be increased when Flunarizine is combined with Gepirone.Approved
FlunitrazepamThe risk or severity of adverse effects can be increased when Flunitrazepam is combined with Gepirone.Approved, Illicit
FluoxetineThe risk or severity of adverse effects can be increased when Gepirone is combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Gepirone.Approved, Investigational, Withdrawn
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Gepirone.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Gepirone.Approved, Illicit, Investigational
FluspirileneThe risk or severity of adverse effects can be increased when Fluspirilene is combined with Gepirone.Approved, Investigational
Fluticasone propionateThe risk or severity of adverse effects can be increased when Fluticasone propionate is combined with Gepirone.Approved
FluvoxamineThe risk or severity of adverse effects can be increased when Fluvoxamine is combined with Gepirone.Approved, Investigational
FosphenytoinThe risk or severity of adverse effects can be increased when Fosphenytoin is combined with Gepirone.Approved, Investigational
FospropofolThe risk or severity of adverse effects can be increased when Fospropofol is combined with Gepirone.Approved, Illicit, Investigational
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Gepirone.Approved, Investigational
Gabapentin EnacarbilThe risk or severity of adverse effects can be increased when Gabapentin Enacarbil is combined with Gepirone.Approved, Investigational
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Gepirone.Approved, Illicit, Investigational
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Gepirone.Approved, Illicit
GuanfacineThe risk or severity of adverse effects can be increased when Guanfacine is combined with Gepirone.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Gepirone.Approved, Illicit, Withdrawn
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with Gepirone.Approved
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Gepirone.Approved, Vet Approved
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Gepirone.Approved, Illicit, Investigational
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Gepirone.Approved
HydrocodoneGepirone may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Gepirone.Approved, Illicit
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Gepirone.Approved
IloperidoneThe risk or severity of adverse effects can be increased when Iloperidone is combined with Gepirone.Approved
ImipramineThe risk or severity of adverse effects can be increased when Imipramine is combined with Gepirone.Approved
IndalpineThe risk or severity of adverse effects can be increased when Gepirone is combined with Indalpine.Investigational, Withdrawn
IndiplonThe risk or severity of adverse effects can be increased when Gepirone is combined with Indiplon.Investigational
IsocarboxazidThe therapeutic efficacy of Gepirone can be increased when used in combination with Isocarboxazid.Approved
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Gepirone.Approved, Vet Approved
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Gepirone.Approved, Vet Approved
KetazolamThe risk or severity of adverse effects can be increased when Ketazolam is combined with Gepirone.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Ketobemidone is combined with Gepirone.Approved, Investigational
LamotrigineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Gepirone.Approved, Investigational
LevetiracetamThe risk or severity of adverse effects can be increased when Levetiracetam is combined with Gepirone.Approved, Investigational
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Gepirone.Approved, Investigational
LevocabastineThe risk or severity of adverse effects can be increased when Gepirone is combined with Levocabastine.Approved, Investigational
LevocetirizineThe risk or severity of adverse effects can be increased when Levocetirizine is combined with Gepirone.Approved
LevodopaThe risk or severity of adverse effects can be increased when Levodopa is combined with Gepirone.Approved
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Gepirone.Approved, Investigational
LevomilnacipranThe risk or severity of adverse effects can be increased when Gepirone is combined with Levomilnacipran.Approved, Investigational
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Gepirone.Approved
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Gepirone.Approved, Vet Approved
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with Gepirone.Approved
LofentanilThe risk or severity of adverse effects can be increased when Lofentanil is combined with Gepirone.Illicit
LoprazolamThe risk or severity of adverse effects can be increased when Gepirone is combined with Loprazolam.Experimental
LoratadineThe risk or severity of adverse effects can be increased when Loratadine is combined with Gepirone.Approved, Investigational
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Gepirone.Approved
LormetazepamThe risk or severity of adverse effects can be increased when Gepirone is combined with Lormetazepam.Approved
LorpiprazoleThe serum concentration of Gepirone can be increased when it is combined with Lorpiprazole.Approved
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Gepirone.Approved
LurasidoneThe risk or severity of adverse effects can be increased when Lurasidone is combined with Gepirone.Approved, Investigational
Magnesium sulfateThe therapeutic efficacy of Gepirone can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
MaprotilineThe risk or severity of adverse effects can be increased when Maprotiline is combined with Gepirone.Approved, Investigational
MebicarThe risk or severity of adverse effects can be increased when Gepirone is combined with Mebicar.Experimental
MeclizineThe risk or severity of adverse effects can be increased when Meclizine is combined with Gepirone.Approved
MedazepamThe risk or severity of adverse effects can be increased when Gepirone is combined with Medazepam.Experimental
MedetomidineThe risk or severity of adverse effects can be increased when Medetomidine is combined with Gepirone.Vet Approved
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Gepirone.Approved, Nutraceutical, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Melperone is combined with Gepirone.Approved, Investigational
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Gepirone.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Gepirone.Approved, Illicit
MeptazinolThe risk or severity of adverse effects can be increased when Gepirone is combined with Meptazinol.Experimental
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Gepirone.Approved, Investigational
MetaxaloneThe risk or severity of adverse effects can be increased when Metaxalone is combined with Gepirone.Approved
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Gepirone.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Gepirone.Approved, Illicit
MethapyrileneThe risk or severity of adverse effects can be increased when Methapyrilene is combined with Gepirone.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Gepirone.Illicit, Withdrawn
MethocarbamolThe risk or severity of adverse effects can be increased when Methocarbamol is combined with Gepirone.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Gepirone.Approved
MethotrimeprazineGepirone may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved, Investigational
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Gepirone.Approved, Investigational, Vet Approved
MethsuximideThe risk or severity of adverse effects can be increased when Methsuximide is combined with Gepirone.Approved
MethylecgonineThe risk or severity of adverse effects can be increased when Methylecgonine is combined with Gepirone.Experimental
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Gepirone.Approved
MetyrosineGepirone may increase the sedative activities of Metyrosine.Approved
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Gepirone.Approved, Illicit
MilnacipranThe risk or severity of adverse effects can be increased when Gepirone is combined with Milnacipran.Approved, Investigational
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Gepirone.Approved, Investigational
MirtazapineGepirone may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MolindoneThe risk or severity of adverse effects can be increased when Molindone is combined with Gepirone.Approved
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Gepirone.Approved, Investigational
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Gepirone.Approved, Investigational
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Gepirone.Approved
NefazodoneThe risk or severity of adverse effects can be increased when Gepirone is combined with Nefazodone.Approved, Withdrawn
NitrazepamThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Gepirone.Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Gepirone.Approved, Vet Approved
NorfluraneThe risk or severity of adverse effects can be increased when Gepirone is combined with Norflurane.Approved, Investigational
NormethadoneThe risk or severity of adverse effects can be increased when Normethadone is combined with Gepirone.Approved, Illicit
NortriptylineThe risk or severity of adverse effects can be increased when Nortriptyline is combined with Gepirone.Approved
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Gepirone.Approved, Investigational
OlopatadineThe risk or severity of adverse effects can be increased when Olopatadine is combined with Gepirone.Approved
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Gepirone.Approved
OpiumThe risk or severity of adverse effects can be increased when Opium is combined with Gepirone.Approved, Illicit
OrphenadrineGepirone may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Osanetant is combined with Gepirone.Investigational
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Gepirone.Approved
OxethazaineThe risk or severity of adverse effects can be increased when Gepirone is combined with Oxethazaine.Approved, Investigational
OxprenololThe risk or severity of adverse effects can be increased when Oxprenolol is combined with Gepirone.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Gepirone.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Gepirone.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Gepirone.Approved, Investigational, Vet Approved
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Gepirone.Approved
ParaldehydeGepirone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
ParoxetineThe risk or severity of adverse effects can be increased when Gepirone is combined with Paroxetine.Approved, Investigational
PenfluridolThe risk or severity of adverse effects can be increased when Gepirone is combined with Penfluridol.Experimental
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Gepirone.Approved, Vet Approved
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Gepirone.Approved, Investigational, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Gepirone.Approved
PerazineThe risk or severity of adverse effects can be increased when Gepirone is combined with Perazine.Approved, Investigational
PerospironeThe risk or severity of adverse effects can be increased when Perospirone is combined with Gepirone.Approved
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Gepirone.Approved
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Gepirone.Approved
PhenazocineThe risk or severity of adverse effects can be increased when Gepirone is combined with Phenazocine.Experimental
PhenibutThe risk or severity of adverse effects can be increased when Gepirone is combined with Phenibut.Experimental
PhenobarbitalThe risk or severity of adverse effects can be increased when Phenobarbital is combined with Gepirone.Approved, Investigational
PhenoperidineThe risk or severity of adverse effects can be increased when Gepirone is combined with Phenoperidine.Experimental
PhenoxyethanolThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Gepirone.Approved
PhenytoinThe risk or severity of adverse effects can be increased when Phenytoin is combined with Gepirone.Approved, Vet Approved
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Gepirone.Approved
PipamperoneThe risk or severity of adverse effects can be increased when Pipamperone is combined with Gepirone.Approved, Investigational
PipotiazineThe risk or severity of adverse effects can be increased when Pipotiazine is combined with Gepirone.Approved, Investigational
PiritramideThe risk or severity of adverse effects can be increased when Gepirone is combined with Piritramide.Approved, Investigational
PizotifenThe risk or severity of adverse effects can be increased when Pizotifen is combined with Gepirone.Approved
PomalidomideThe risk or severity of adverse effects can be increased when Pomalidomide is combined with Gepirone.Approved
PramipexoleGepirone may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Pramocaine is combined with Gepirone.Approved
PrazepamThe risk or severity of adverse effects can be increased when Prazepam is combined with Gepirone.Approved, Illicit
PregabalinThe therapeutic efficacy of Gepirone can be increased when used in combination with Pregabalin.Approved, Illicit, Investigational
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Gepirone.Approved
PrimidoneThe risk or severity of adverse effects can be increased when Primidone is combined with Gepirone.Approved, Vet Approved
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Gepirone.Approved, Investigational, Vet Approved
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Gepirone.Approved, Vet Approved
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Gepirone.Approved, Vet Approved
PromethazineThe risk or severity of adverse effects can be increased when Promethazine is combined with Gepirone.Approved, Investigational
PropanididThe risk or severity of adverse effects can be increased when Gepirone is combined with Propanidid.Experimental
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Gepirone.Approved, Vet Approved
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Gepirone.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Gepirone.Approved
ProtriptylineThe risk or severity of adverse effects can be increased when Protriptyline is combined with Gepirone.Approved
ProxibarbalThe risk or severity of adverse effects can be increased when Gepirone is combined with Proxibarbal.Experimental
PSD502The risk or severity of adverse effects can be increased when PSD502 is combined with Gepirone.Investigational
QuazepamThe risk or severity of adverse effects can be increased when Quazepam is combined with Gepirone.Approved, Illicit
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Gepirone.Approved
QuinisocaineThe risk or severity of adverse effects can be increased when Gepirone is combined with Quinisocaine.Experimental
RacloprideThe risk or severity of adverse effects can be increased when Gepirone is combined with Raclopride.Investigational
RamelteonThe risk or severity of adverse effects can be increased when Ramelteon is combined with Gepirone.Approved, Investigational
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Gepirone.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Gepirone.Approved, Withdrawn
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Gepirone.Approved, Investigational
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Gepirone.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Gepirone is combined with Ritanserin.Investigational
RomifidineThe risk or severity of adverse effects can be increased when Romifidine is combined with Gepirone.Vet Approved
RopiniroleGepirone may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Gepirone.Approved
RotigotineGepirone may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Gepirone.Approved
ScopolamineThe risk or severity of adverse effects can be increased when Scopolamine is combined with Gepirone.Approved, Investigational
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Gepirone.Approved, Vet Approved
SepranoloneThe risk or severity of adverse effects can be increased when Gepirone is combined with Sepranolone.Investigational
SertindoleThe risk or severity of adverse effects can be increased when Sertindole is combined with Gepirone.Approved, Investigational, Withdrawn
SertralineThe risk or severity of adverse effects can be increased when Gepirone is combined with Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Gepirone.Approved, Vet Approved
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Gepirone.Approved
StiripentolThe risk or severity of adverse effects can be increased when Stiripentol is combined with Gepirone.Approved
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Gepirone.Approved, Investigational
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Gepirone.Approved, Investigational
SultoprideThe risk or severity of adverse effects can be increased when Gepirone is combined with Sultopride.Experimental
SuvorexantGepirone may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved, Investigational
TandospironeThe risk or severity of adverse effects can be increased when Gepirone is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Gepirone.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Tasimelteon is combined with Gepirone.Approved, Investigational
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Gepirone.Approved, Investigational
TetrabenazineThe risk or severity of adverse effects can be increased when Tetrabenazine is combined with Gepirone.Approved, Investigational
TetracaineThe risk or severity of adverse effects can be increased when Tetracaine is combined with Gepirone.Approved, Vet Approved
TetrahydropalmatineThe risk or severity of adverse effects can be increased when Tetrahydropalmatine is combined with Gepirone.Investigational
TetrodotoxinThe risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Gepirone.Investigational
ThalidomideGepirone may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Gepirone.Approved, Vet Approved
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Gepirone.Approved, Vet Approved
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Gepirone.Approved, Withdrawn
ThiothixeneThe risk or severity of adverse effects can be increased when Thiothixene is combined with Gepirone.Approved
TiagabineThe risk or severity of adverse effects can be increased when Tiagabine is combined with Gepirone.Approved, Investigational
TiaprideThe risk or severity of adverse effects can be increased when Gepirone is combined with Tiapride.Approved, Investigational
TiletamineThe risk or severity of adverse effects can be increased when Tiletamine is combined with Gepirone.Vet Approved
TilidineThe risk or severity of adverse effects can be increased when Gepirone is combined with Tilidine.Experimental
TizanidineThe risk or severity of adverse effects can be increased when Tizanidine is combined with Gepirone.Approved, Investigational
TolcaponeThe risk or severity of adverse effects can be increased when Tolcapone is combined with Gepirone.Approved, Withdrawn
TopiramateThe risk or severity of adverse effects can be increased when Topiramate is combined with Gepirone.Approved
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Gepirone.Approved, Investigational
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Gepirone.Approved, Investigational
TrazodoneThe risk or severity of adverse effects can be increased when Trazodone is combined with Gepirone.Approved, Investigational
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Gepirone.Approved, Investigational
Tricaine methanesulfonateThe risk or severity of adverse effects can be increased when Tricaine methanesulfonate is combined with Gepirone.Vet Approved
TrichloroethyleneThe risk or severity of adverse effects can be increased when Gepirone is combined with Trichloroethylene.Approved
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Gepirone.Approved, Investigational
TrifluperidolThe risk or severity of adverse effects can be increased when Gepirone is combined with Trifluperidol.Experimental
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Gepirone.Approved, Vet Approved
TrimipramineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Gepirone.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Triprolidine is combined with Gepirone.Approved
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Gepirone.Approved, Investigational
VemurafenibThe risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Gepirone.Approved
VenlafaxineThe risk or severity of adverse effects can be increased when Gepirone is combined with Venlafaxine.Approved
VeraliprideThe risk or severity of adverse effects can be increased when Gepirone is combined with Veralipride.Experimental
VigabatrinThe risk or severity of adverse effects can be increased when Vigabatrin is combined with Gepirone.Approved
Vinyl etherThe risk or severity of adverse effects can be increased when Gepirone is combined with Vinyl ether.Experimental
VortioxetineThe risk or severity of adverse effects can be increased when Vortioxetine is combined with Gepirone.Approved, Investigational
XenonThe risk or severity of adverse effects can be increased when Gepirone is combined with Xenon.Experimental
XylazineThe risk or severity of adverse effects can be increased when Xylazine is combined with Gepirone.Vet Approved
YohimbineThe therapeutic efficacy of Gepirone can be decreased when used in combination with Yohimbine.Approved, Investigational, Vet Approved
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Gepirone.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Ziconotide is combined with Gepirone.Approved
ZimelidineThe risk or severity of adverse effects can be increased when Gepirone is combined with Zimelidine.Withdrawn
ZiprasidoneThe risk or severity of adverse effects can be increased when Ziprasidone is combined with Gepirone.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Zolazepam is combined with Gepirone.Vet Approved
ZolpidemGepirone may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe risk or severity of adverse effects can be increased when Zonisamide is combined with Gepirone.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Gepirone.Approved
ZotepineThe risk or severity of adverse effects can be increased when Zotepine is combined with Gepirone.Approved, Investigational, Withdrawn
ZuclopenthixolThe risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Gepirone.Approved, Investigational
Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Compound
55191
PubChem Substance
347828470
ChemSpider
49836
BindingDB
50005132
ChEBI
135990
ChEMBL
CHEMBL284092
Wikipedia
Gepirone
ATC Codes
N06AX19 — Gepirone

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2CompletedTreatmentCocaine-Related Disorders1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility1.09 mg/mLALOGPS
logP2.09ALOGPS
logP1.35ChemAxon
logS-2.5ALOGPS
pKa (Strongest Basic)7.62ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area69.64 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity101.49 m3·mol-1ChemAxon
Polarizability40.93 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as n-arylpiperazines. These are organic compounds containing a piperazine ring where the nitrogen ring atom carries an aryl group.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Diazinanes
Sub Class
Piperazines
Direct Parent
N-arylpiperazines
Alternative Parents
Piperidinediones / Dialkylarylamines / N-alkylpiperazines / Delta lactams / Aminopyrimidines and derivatives / N-substituted carboxylic acid imides / Heteroaromatic compounds / Dicarboximides / Trialkylamines / Amino acids and derivatives
show 5 more
Substituents
N-arylpiperazine / Piperidinedione / Dialkylarylamine / Aminopyrimidine / Delta-lactam / Piperidinone / N-alkylpiperazine / Pyrimidine / Piperidine / Carboxylic acid imide, n-substituted
show 19 more
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
Not Available

Drug created on October 20, 2016 15:33 / Updated on March 02, 2018 05:30