Major Depressive Disorder (MDD)

Also known as: Major depressive disorder / Major depression / Depressive Disorder, Major / Major depressive disorder NOS / Major depressive disorders / MDD / Depression NOS / Major depressive illness

DrugDrug NameDrug Description
DB01238AripiprazoleAripiprazole is an atypical antipsychotic medication used for the treatment of schizophrenia. It has also recently received FDA approval for the treatment of acute manic and mixed episodes associated with bipolar disorder. Aripiprazole appears to mediate its antipsychotic effects primarily by partial agonism at the D2 receptor. In addition to partial agonist activity at the D2 receptor, aripiprazole is also a partial agonist at the 5-HT1A receptor, and like the other atypical antipsychotics, aripiprazole displays an antagonist profile at the 5-HT2A receptor. Aripiprazole has moderate affinity for histamine and alpha adrenergic receptors, and no appreciable affinity for cholinergic muscarinic receptors.
DB01156BupropionA unicyclic, aminoketone antidepressant. The mechanism of its therapeutic actions is not well understood, but it does appear to block dopamine uptake. The hydrochloride is available as an aid to smoking cessation treatment.
DB00215CitalopramCitalopram belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). In spite of structural differences between compounds in this class, the SSRIs possess similar pharmacological activity. As with other antidepressant agents, several weeks of therapy may be indicated before a clinical effect is noticed. SSRIs are potent inhibitors of serotonin reuptake in the neurons. They have little to no effect on norepinephrine or dopamine reuptake and do not antagonize α- or β-adrenergic, dopamine D2 or histamine H1 receptors. During acute usage, SSRIs inhibit serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Chronic use leads to desensitization of somatodendritic 5-HT1A and terminal autoreceptors. The general clinical effect of increased mood and decreased anxiety is thought to be due to adaptive changes in neuronal function that leads to enhanced serotonergic neurotransmission. Side effects include dry mouth, nausea, dizziness, drowsiness, sexual dysfunction, and headache. Side effects generally occur within the first two weeks of therapy and are usually less severe and frequent than those observed with tricyclic antidepressants. Citalopram is approved for treatment of depression. Unlabeled indications include mild dementia-associated agitation in nonpsychotic patients, smoking cessation, ethanol abuse, obsessive-compulsive disorder (OCD) in children, and diabetic neuropathy [A325, FDA label].
DB06700DesvenlafaxineDesvenlafaxine (O-desmethylvenlafaxine) the major active metabolite of venlafaxine, is an antidepressant from the serotonin-norepinephrine reuptake inhibitor (SNRI class). Desvenlafaxine may be used to treat major depressive disorder and is being studied for use in the management of vasomotor symptoms in postmenopausal women. It is formulated as an extended release tablet. FDA approved in 2008.
DB00476DuloxetineDuloxetine (brand names Cymbalta, Yentreve, and in parts of Europe, Xeristar or Ariclaim) is a drug which primarily targets major depressive disorder (MDD), generalized anxiety disorder (GAD), pain related to diabetic peripheral neuropathy and in some countries stress urinary incontinence (SUI). It is manufactured and marketed by Eli Lilly and Company. Duloxetine has not yet been FDA approved for stress urinary incontinence or for fibromyalgia. Duloxetine is a selective SNRI (selective serotonin-norepinephrine reuptake inhibitor). Duloxetine is a systemic drug therapy which affects the body as a whole. Known also under the code name LY248686, it is a potent dual reuptake inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE), possessing comparable affinities in binding to NE- and 5-HT transporter sites. It is a less potent inhibitor of dopamine reuptake.
DB01175EscitalopramEscitalopram, the S-enantiomer of citalopram, belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). Despite distinct structural differences between compounds in this class, SSRIs possess similar pharmacological activity. As with other antidepressant agents, several weeks of therapy may be required before a clinical effect is seen. SSRIs are potent inhibitors of neuronal serotonin reuptake. They have little to no effect on norepinephrine or dopamine reuptake and do not antagonize α- or β-adrenergic, dopamine D2 or histamine H1 receptors. During acute use, SSRIs block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Chronic use leads to desensitization of somatodendritic 5-HT1A and terminal autoreceptors. The overall clinical effect of increased mood and decreased anxiety is thought to be due to adaptive changes in neuronal function that leads to enhanced serotonergic neurotransmission. Side effects include dry mouth, nausea, dizziness, drowsiness, sexual dysfunction and headache. Side effects generally occur within the first two weeks of therapy and are usually less severe and frequent than those observed with tricyclic antidepressants. Escitalopram may be used to treat major depressive disorder (MDD) and generalized anxiety disorder (GAD).
DB00176FluvoxamineFluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database comprised of approximately 35,000 patients. It was launched in the US in December 1994 and in Japan in June 1999. As of the end of 1995, more than 10 million patients worldwide have been treated with fluvoxamine.
DB00458ImipramineImipramine, the prototypical tricyclic antidepressant (TCA), is a dibenzazepine-derivative TCA. TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, imipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, imipramine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as imipramine and amitriptyline, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline and desipramine. TCAs also block histamine H1 receptors, α1-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively [A6584]. Imipramine has less sedative and anticholinergic effects than the tertiary amine TCAs, amitriptyline and clomipramine. Imipramine may be used to treat depression and nocturnal enuresis in children [FDA Label]. Unlabeled indications include chronic and neuropathic pain (including diabetic neuropathy), panic disorder, attention-deficit/hyperactivity disorder (ADHD), and post-traumatic stress disorder (PTSD) [L1349,L1348,A31900,L1351,L1352,L1353,A31904].
DB08918LevomilnacipranLevomilnacipran is a selective serotonin and norepinephrine reuptake inhibitor. Chemically, levomilnacipran is the 1S,2R-enantiomer of milnacipran. FDA approved on July 25, 2013.
DB00934MaprotilineMaprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does not appear to block serotonin reuptake. Maprotiline may be used to treat depressive affective disorders, including dysthymic disorder (depressive neurosis) and major depressive disorder. Maprotiline is effective at reducing symptoms of anxiety associated with depression.
DB00370MirtazapineMirtazapine is an antidepressant introduced by Organon International in 1996 used for the treatment of moderate to severe depression. Mirtazapine has a tetracyclic chemical structure and is classified as a noradrenergic and specific serotonergic antidepressant (NaSSA). It is the only tetracyclic antidepressant that has been approved by the Food and Drug Administration to treat depression. [Wikipedia]
DB01171MoclobemideA reversible monoamine oxidase inhibitor (MAOI) selective for isoform A (RIMA) used to treat major depressive disorder. Most meta-analyses and most studies indicate that in the acute management of depression, moclobemide is more efficacious than placebo medication and similarly efficacious as tricyclic antidepressants (TCA) or selective serotonin reuptake inhibitors (SSRIs). Due to negligible anticholinergic and antihistaminic actions, moclobemide has been better tolerated than tri- or heterocyclic antidepressants [A3901].
DB00540NortriptylineNortriptyline hydrochloride, the N-demethylated active metabolite of amitriptyline, is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, nortriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, nortriptyline exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Secondary amine TCAs, such as nortriptyline, are more potent inhibitors of norepinephrine reuptake than tertiary amine TCAs, such as amitriptyline. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine-H1 receptors, α1-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. Compared to other TCAs, nortriptyline is less toxic and displays less drug interactions [A6584]. As a more selective noadrenaline reuptake inhibitor, nortriptyline is less likely associated with the hypertensive ‘cheese reaction' [A6584]. Nortriptyline exerts less anticholinergic and sedative side effects compared to the tertiary amine TCAs, amitriptyline and clomipramine. Apart from its indication to treat depression, nortriptyline has been investigated in chronic neuropathic pain (unlabeled use), fibromyalgia [A31911], irritable bowel syndrome (unlabeled use), diabetic neuropathy (unlabeled use) [A31912], post-traumatic stress disorder (unlabeled use), and migraine prophylaxis (unlabeled use).
DB00715ParoxetineParoxetine hydrochloride and paroxetine mesylate belong to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). Despite distinct structural differences between compounds in this class, SSRIs possess similar pharmacological activity. As with other antidepressant agents, several weeks of therapy may be required before a clinical effect is seen. SSRIs are potent inhibitors of neuronal serotonin reuptake. They have little to no effect on norepinephrine or dopamine reuptake and do not antagonize ⍺- or β-adrenergic, dopamine D2 or histamine H1 receptors. During acute use, SSRIs block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Chronic use leads to desensitization of somatodendritic 5-HT1A and terminal autoreceptors. The overall clinical effect of increased mood and decreased anxiety is thought to be due to adaptive changes in neuronal function that leads to enhanced serotonergic neurotransmission. Side effects include dry mouth, nausea, dizziness, drowsiness, sexual dysfunction and headache (see Toxicity section below for a complete listing of side effects). Side effects generally occur during the first two weeks of therapy and are usually less severe and frequent than those observed with tricyclic antidepressants. Paroxetine hydrochloride and mesylate are considered therapeutic alternatives rather than generic equivalents by the US Food and Drug Administration (FDA); both agents contain the same active moiety (i.e. paroxetine), but are formulated as different salt forms. Clinical studies establishing the efficacy of paroxetine in various conditions were performed using paroxetine hydrochloride. Since both agents contain the same active moiety, the clinical efficacy of both agents is thought to be similar. Paroxetine may be used to treat major depressive disorder (MDD), panic disorder with or without agoraphobia, obsessive-compulsive disorder (OCD), social anxiety disorder (social phobia), generalized anxiety disorder (GAD), post-traumatic stress disorder (PTSD) and premenstrual dysphoric disorder (PMDD). Paroxetine has the most evidence supporting its use for anxiety-related disorders of the SSRIs. It has the greatest anticholinergic activity of the agents in this class and compared to other SSRIs, paroxetine may cause greater weight gain, sexual dysfunction, sedation and constipation.
DB01037SelegilineA selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson's disease. It may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodopa upon onset of disability. (From AMA Drug Evaluations Annual, 1994, p385) The compound without isomeric designation is Deprenyl.
DB01104SertralineSertraline hydrochloride belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). Despite distinct structural differences between compounds in this class, SSRIs possess similar pharmacological activity. As with other antidepressant agents, several weeks of therapy may be required before a clinical effect is seen. SSRIs are potent inhibitors of neuronal serotonin reuptake [T28]. They have little to no effect on norepinephrine or dopamine reuptake and do not antagonize α- or β-adrenergic, dopamine D2 or histamine H1 receptors. During acute use, SSRIs block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Chronic use leads to desensitization of somatodendritic 5-HT1A and terminal autoreceptors. The overall clinical effect of increased mood and decreased anxiety is thought to be due to adaptive changes in neuronal function that leads to enhanced serotonergic neurotransmission. Side effects include dry mouth, nausea, dizziness, drowsiness, sexual dysfunction and headache (see Toxicity section below for a more detailed listing of side effects). Compared to other agents in this class, sertraline may cause greater diarrheal and male sexual dysfunction effects [A1844]. Sertraline displays a better safety or tolerability profile than other classes of antidepressants [A1846]. Side effects generally occur within the first two weeks of therapy and are usually less severe and frequent than those observed with tricyclic antidepressants or monoamine oxidase inhibitors [T28]. Sertraline has shown therapeutic effectiveness as a treatment for major depressive disorder [A1836], obsessive-compulsive disorder (OCD) [A1838], panic disorder, post-traumatic stress disorder (PTSD) [A1841], premenstrual dysphoric disorder (PMDD) [A1842] and social anxiety disorder (social phobia).
DB00656TrazodoneA serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309)
DB00285VenlafaxineVenlafaxine (Effexor) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class first introduced by Wyeth in 1993. It is prescribed for the treatment of clinical depression and anxiety disorders. Due to the pronounced side effects and suspicions that venlafaxine may significantly increase the risk of suicide it is not recommended as a first line treatment of depression. However, it is often effective for depression not responding to SSRIs. Venlafaxine was the sixth most widely-used antidepressant based on the amount of retail prescriptions in the US (17.1 million) in 2006. [Wikipedia]
DB06684VilazodoneVilazodone is a novel compound with combined high affinity and selectivity for the 5-hydroxytryptamine (5-HT) transporter and 5-HT(1A) receptors. It has been shown to be equally efficacious as other antidepressants with similar gastrointestinal side effects and possibly with reduced sexual side effects and weight gain. Vilazodone is an antidepressant agent that can used as an alternative for patients who cannot tolerate therapy with other antidepressant classes such as selective serotonin reuptake inhibitors or serotonin norepinephrine reuptake inhibitors. Treatment should be titrated towards the target dose, which is 40mg per day.
DB09068VortioxetineVortioxetine is an atypical antipsychotic and antidepressant indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and simulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin receptors and inhibits the reuptake of serotonin. More specifically, vortioxetine acts via the following biological mechanisms: as a serotonin reuptake inhibitor (SRI) through inhibition of the serotonin transporter, as a partial agonist of the 5-HT1B receptor, an agonist of 5-HT1A, and an antagonist of the 5-HT3, 5-HT1D, and 5-HT7 receptors. SMSs were developed because there are many different subtypes of serotonin receptors, however, not all of these receptors appear to be involved in the antidepressant effects of SRIs. Some serotonin receptors seem to play a relatively neutral or insignificant role in the regulation of mood, but others, such as 5-HT1A autoreceptors and 5-HT7 receptors, appear to play an oppositional role in the efficacy of SRIs in treating depression.
DrugDrug NameTargetType
DB01238AripiprazoleD(2) dopamine receptortarget
DB01238Aripiprazole5-hydroxytryptamine receptor 1Atarget
DB01238Aripiprazole5-hydroxytryptamine receptor 2Atarget
DB01238AripiprazoleCytochrome P450 3A4enzyme
DB01238AripiprazoleCytochrome P450 2D6enzyme
DB01238Aripiprazole5-hydroxytryptamine receptor 1Btarget
DB01238Aripiprazole5-hydroxytryptamine receptor 1Dtarget
DB01238Aripiprazole5-hydroxytryptamine receptor 1Etarget
DB01238AripiprazoleD(1A) dopamine receptortarget
DB01238AripiprazoleD(1B) dopamine receptortarget
DB01238AripiprazoleD(3) dopamine receptortarget
DB01238AripiprazoleD(4) dopamine receptortarget
DB01238Aripiprazole5-hydroxytryptamine receptor 2Ctarget
DB01238Aripiprazole5-hydroxytryptamine receptor 3Atarget
DB01238Aripiprazole5-hydroxytryptamine receptor 6target
DB01238Aripiprazole5-hydroxytryptamine receptor 7target
DB01238AripiprazoleHistamine H1 receptortarget
DB01238AripiprazoleAlpha-1A adrenergic receptortarget
DB01238AripiprazoleAlpha-1B adrenergic receptortarget
DB01238AripiprazoleAlpha-2A adrenergic receptortarget
DB01238AripiprazoleAlpha-2B adrenergic receptortarget
DB01238AripiprazoleAlpha-2C adrenergic receptortarget
DB01238AripiprazoleMuscarinic acetylcholine receptor M1target
DB01238AripiprazoleMuscarinic acetylcholine receptor M2target
DB01238AripiprazoleMuscarinic acetylcholine receptor M3target
DB01238AripiprazoleMuscarinic acetylcholine receptor M4target
DB01238AripiprazoleMuscarinic acetylcholine receptor M5target
DB01238AripiprazoleCytochrome P450 3A5enzyme
DB01238AripiprazoleCytochrome P450 3A7enzyme
DB01156BupropionSodium-dependent dopamine transportertarget
DB01156BupropionSodium-dependent noradrenaline transportertarget
DB01156BupropionCytochrome P450 2B6enzyme
DB01156BupropionCytochrome P450 2D6enzyme
DB01156BupropionAlpha-1-acid glycoprotein 1carrier
DB01156BupropionNeuronal acetylcholine receptor subunit alpha-3target
DB01156BupropionCytochrome P450 1A2enzyme
DB01156BupropionCytochrome P450 2A6enzyme
DB01156BupropionCytochrome P450 2C8enzyme
DB01156BupropionCytochrome P450 2C9enzyme
DB01156BupropionCytochrome P450 2E1enzyme
DB01156BupropionCytochrome P450 3A4enzyme
DB00215CitalopramSodium-dependent serotonin transportertarget
DB00215CitalopramCytochrome P450 2C19enzyme
DB00215CitalopramCytochrome P450 2D6enzyme
DB00215CitalopramCytochrome P450 3A4enzyme
DB00215CitalopramMultidrug resistance protein 1transporter
DB00215CitalopramCytochrome P450 1A2enzyme
DB00215CitalopramCytochrome P450 2B6enzyme
DB00215CitalopramCytochrome P450 2E1enzyme
DB00215CitalopramHistamine H1 receptortarget
DB00215CitalopramSodium-dependent dopamine transportertransporter
DB00215CitalopramSodium-dependent noradrenaline transportertransporter
DB00215CitalopramSodium-dependent serotonin transportertransporter
DB00215CitalopramAlpha-1A adrenergic receptortarget
DB00215CitalopramMuscarinic acetylcholine receptor M1target
DB00215Citalopram5-hydroxytryptamine receptor 2Ctarget
DB06700DesvenlafaxineCytochrome P450 3A4enzyme
DB06700DesvenlafaxineSodium-dependent serotonin transportertarget
DB06700DesvenlafaxineSodium-dependent noradrenaline transportertarget
DB00476DuloxetineSodium-dependent serotonin transportertarget
DB00476DuloxetineSodium-dependent dopamine transportertarget
DB00476DuloxetineSodium-dependent noradrenaline transportertarget
DB00476DuloxetineCytochrome P450 1A2enzyme
DB00476DuloxetineCytochrome P450 2D6enzyme
DB01175EscitalopramSodium-dependent serotonin transportertarget
DB01175EscitalopramCytochrome P450 3A4enzyme
DB01175EscitalopramCytochrome P450 2D6enzyme
DB01175EscitalopramSodium-dependent dopamine transportertarget
DB01175EscitalopramSodium-dependent noradrenaline transportertarget
DB01175EscitalopramAlpha-1A adrenergic receptortarget
DB01175EscitalopramMuscarinic acetylcholine receptor M1target
DB01175EscitalopramHistamine H1 receptortarget
DB01175EscitalopramCytochrome P450 2C19enzyme
DB00176FluvoxamineSodium-dependent serotonin transportertarget
DB00176FluvoxamineCytochrome P450 1A2enzyme
DB00176FluvoxamineCytochrome P450 2D6enzyme
DB00176FluvoxamineCytochrome P450 2C9enzyme
DB00176FluvoxamineCytochrome P450 2C19enzyme
DB00176FluvoxamineCytochrome P450 1A1enzyme
DB00176FluvoxamineCytochrome P450 3A4enzyme
DB00176FluvoxamineCytochrome P450 3A5enzyme
DB00176FluvoxamineCytochrome P450 3A7enzyme
DB00176FluvoxamineMultidrug resistance protein 1transporter
DB00176FluvoxamineCytochrome P450 2B6enzyme
DB00176FluvoxamineCytochrome P450 2E1enzyme
DB00176FluvoxaminePotassium voltage-gated channel subfamily H member 2target
DB00458ImipramineAlpha-1-acid glycoprotein 1carrier
DB00458ImipramineSerum albumincarrier
DB00458ImipramineCytochrome P450 2D6enzyme
DB00458ImipramineCytochrome P450 2C19enzyme
DB00458ImipramineCytochrome P450 1A2enzyme
DB00458ImipramineCytochrome P450 3A4enzyme
DB00458ImipramineCytochrome P450 3A7enzyme
DB00458ImipramineCytochrome P450 2B6enzyme
DB00458ImipramineCytochrome P450 2C18enzyme
DB00458ImipramineCytochrome P450 2E1enzyme
DB00458ImipramineSodium-dependent noradrenaline transportertarget
DB00458ImipramineSodium-dependent serotonin transportertarget
DB00458Imipramine5-hydroxytryptamine receptor 2Atarget
DB00458ImipramineHistamine H1 receptortarget
DB00458ImipramineAlpha-1A adrenergic receptortarget
DB00458ImipramineAlpha-1D adrenergic receptortarget
DB00458ImipramineMuscarinic acetylcholine receptor M1target
DB00458ImipramineMuscarinic acetylcholine receptor M2target
DB00458ImipramineMuscarinic acetylcholine receptor M3target
DB00458ImipramineMuscarinic acetylcholine receptor M4target
DB00458ImipramineMuscarinic acetylcholine receptor M5target
DB00458ImipraminePotassium voltage-gated channel subfamily D member 2target
DB00458ImipraminePotassium voltage-gated channel subfamily D member 3target
DB00458Imipramine5-hydroxytryptamine receptor 2Ctarget
DB00458ImipramineAlpha-1B adrenergic receptortarget
DB00458Imipramine5-hydroxytryptamine receptor 7target
DB00458ImipramineD(1) dopamine receptortarget
DB00458ImipramineD(2) dopamine receptortarget
DB00458ImipraminePotassium voltage-gated channel subfamily H member 2target
DB00458ImipramineSodium-dependent dopamine transportertarget
DB00458Imipramine5-hydroxytryptamine receptor 1Atarget
DB00458Imipramine5-hydroxytryptamine receptor 6target
DB00458ImipraminePotassium voltage-gated channel subfamily H member 1target
DB00458ImipramineAlpha-1-acid glycoprotein 2target
DB00458ImipramineSolute carrier family 22 member 1transporter
DB00458ImipramineMultidrug resistance protein 1transporter
DB00458ImipramineSolute carrier family 22 member 2transporter
DB00458ImipramineSolute carrier family 22 member 3transporter
DB00458ImipramineSolute carrier family 22 member 4transporter
DB08918LevomilnacipranCytochrome P450 3A4enzyme
DB08918LevomilnacipranCytochrome P450 2C8enzyme
DB08918LevomilnacipranCytochrome P450 2C19enzyme
DB08918LevomilnacipranCytochrome P450 2D6enzyme
DB08918LevomilnacipranCytochrome P450 2J2enzyme
DB08918LevomilnacipranSodium-dependent serotonin transportertarget
DB08918LevomilnacipranSodium-dependent noradrenaline transportertarget
DB08918LevomilnacipranMultidrug resistance protein 1transporter
DB00934MaprotilineHistamine H1 receptortarget
DB00934MaprotilineSodium-dependent noradrenaline transportertarget
DB00934MaprotilineAlpha-1 adrenergic receptorstarget
DB00934MaprotilineCytochrome P450 2D6enzyme
DB00934MaprotilineAlpha-1-acid glycoprotein 1carrier
DB00934MaprotilineMultidrug resistance protein 1transporter
DB00934MaprotilineMuscarinic acetylcholine receptor M1target
DB00934MaprotilineMuscarinic acetylcholine receptor M2target
DB00934MaprotilineMuscarinic acetylcholine receptor M3target
DB00934MaprotilineMuscarinic acetylcholine receptor M4target
DB00934MaprotilineMuscarinic acetylcholine receptor M5target
DB00934MaprotilineCytochrome P450 1A2enzyme
DB00934Maprotiline5-hydroxytryptamine receptor 2Atarget
DB00934Maprotiline5-hydroxytryptamine receptor 2Ctarget
DB00934Maprotiline5-hydroxytryptamine receptor 7target
DB00934MaprotilineD(2) dopamine receptortarget
DB00934MaprotilineAlpha-2 adrenergic receptorstarget
DB00370Mirtazapine5-hydroxytryptamine receptor 2Atarget
DB00370Mirtazapine5-hydroxytryptamine receptor 3Atarget
DB00370MirtazapineAlpha-2A adrenergic receptortarget
DB00370Mirtazapine5-hydroxytryptamine receptor 2Ctarget
DB00370MirtazapineKappa-type opioid receptortarget
DB00370MirtazapineHistamine H1 receptortarget
DB00370MirtazapineCytochrome P450 1A2enzyme
DB00370MirtazapineCytochrome P450 3A4enzyme
DB00370MirtazapineCytochrome P450 2D6enzyme
DB00370MirtazapineCytochrome P450 2C8enzyme
DB00370MirtazapineCytochrome P450 2C9enzyme
DB00370MirtazapineAlpha-2C adrenergic receptortarget
DB00370Mirtazapine5-hydroxytryptamine receptor 7target
DB00370MirtazapineAlpha-1 adrenergic receptorstarget
DB00370MirtazapineD(2) dopamine receptortarget
DB00370MirtazapineD(3) dopamine receptortarget
DB00370MirtazapineSodium-dependent noradrenaline transportertarget
DB00370MirtazapineSodium-dependent serotonin transportertarget
DB00370MirtazapineSodium-dependent dopamine transportertarget
DB00370Mirtazapine5-hydroxytryptamine receptor 2Btarget
DB00370MirtazapineD(1) dopamine receptortarget
DB00370MirtazapineHistamine H3 receptortarget
DB00370MirtazapineAlpha-1A adrenergic receptortarget
DB00370MirtazapineBeta-1 adrenergic receptortarget
DB00370MirtazapineBeta-2 adrenergic receptortarget
DB01171MoclobemideAmine oxidase [flavin-containing] Atarget
DB01171MoclobemideCytochrome P450 2C19enzyme
DB01171MoclobemideCytochrome P450 2D6enzyme
DB01171MoclobemideAmine oxidase [flavin-containing] Aenzyme
DB01171MoclobemideAmine oxidase [flavin-containing] Benzyme
DB01171MoclobemideCytochrome P450 1A2enzyme
DB01171MoclobemideCytochrome P450 2C9enzyme
DB01171MoclobemideMonoamine oxidasetarget
DB01171MoclobemideAmine oxidase [flavin-containing] Btarget
DB00540NortriptylineSodium-dependent serotonin transportertarget
DB00540NortriptylineSodium-dependent noradrenaline transportertarget
DB00540NortriptylineCytochrome P450 1A2enzyme
DB00540NortriptylineCytochrome P450 2D6enzyme
DB00540NortriptylineSerum albumincarrier
DB00540NortriptylineAlpha-1-acid glycoprotein 1carrier
DB00540NortriptylineHistamine H1 receptortarget
DB00540NortriptylineMuscarinic acetylcholine receptor M1target
DB00540NortriptylineMuscarinic acetylcholine receptor M2target
DB00540NortriptylineMuscarinic acetylcholine receptor M3target
DB00540NortriptylineMuscarinic acetylcholine receptor M4target
DB00540NortriptylineMuscarinic acetylcholine receptor M5target
DB00540Nortriptyline5-hydroxytryptamine receptor 2Atarget
DB00540NortriptylineAlpha-1A adrenergic receptortarget
DB00540Nortriptyline5-hydroxytryptamine receptor 1Atarget
DB00540NortriptylineCytochrome P450 3A4enzyme
DB00540NortriptylineCytochrome P450 3A5enzyme
DB00540NortriptylineAlpha-1D adrenergic receptortarget
DB00540NortriptylineCytochrome P450 2C19enzyme
DB00540NortriptylineCytochrome P450 2C9enzyme
DB00540NortriptylineProstaglandin G/H synthase 1enzyme
DB00540NortriptylineCytochrome P450 2E1enzyme
DB00540Nortriptyline5-hydroxytryptamine receptor 2Ctarget
DB00540Nortriptyline5-hydroxytryptamine receptor 6target
DB00540NortriptylineAlpha-1B adrenergic receptortarget
DB00540NortriptylineAlpha-2 adrenergic receptorstarget
DB00540NortriptylineBeta adrenergic receptortarget
DB00540NortriptylineD(2) dopamine receptortarget
DB00540NortriptylineSigma receptortarget
DB00540Nortriptyline5-hydroxytryptamine receptor 1Ctarget
DB00715ParoxetineCytochrome P450 2D6enzyme
DB00715ParoxetineCytochrome P450 2C9enzyme
DB00715ParoxetineCytochrome P450 2B6enzyme
DB00715ParoxetineCytochrome P450 2C8enzyme
DB00715ParoxetineCytochrome P450 1A2enzyme
DB00715ParoxetineSodium-dependent serotonin transportertarget
DB00715ParoxetineSodium-dependent noradrenaline transportertarget
DB00715Paroxetine5-hydroxytryptamine receptor 2Atarget
DB00715ParoxetineMuscarinic acetylcholine receptor M1target
DB00715ParoxetineMuscarinic acetylcholine receptor M2target
DB00715ParoxetineMuscarinic acetylcholine receptor M3target
DB00715ParoxetineMuscarinic acetylcholine receptor M4target
DB00715ParoxetineMuscarinic acetylcholine receptor M5target
DB00715ParoxetineMultidrug resistance protein 1transporter
DB01037SelegilineAmine oxidase [flavin-containing] Btarget
DB01037SelegilineCytochrome P450 2B6enzyme
DB01037SelegilineAmine oxidase [flavin-containing] Atarget
DB01037SelegilineCytochrome P450 2A6enzyme
DB01037SelegilineCytochrome P450 3A4enzyme
DB01037SelegilineMultidrug resistance protein 1transporter
DB01037SelegilineCytochrome P450 1A2enzyme
DB01037SelegilineCytochrome P450 2C19enzyme
DB01037SelegilineCytochrome P450 2C8enzyme
DB01037SelegilineCytochrome P450 2C9enzyme
DB01037SelegilineCytochrome P450 2D6enzyme
DB01037SelegilineCytochrome P450 2E1enzyme
DB01104SertralineSodium-dependent serotonin transportertarget
DB01104SertralineCytochrome P450 2B6enzyme
DB01104SertralineCytochrome P450 2C19enzyme
DB01104SertralineCytochrome P450 2C9enzyme
DB01104SertralineCytochrome P450 2D6enzyme
DB01104SertralineSodium-dependent dopamine transportertarget
DB01104SertralineCYP2B proteinenzyme
DB01104SertralineCytochrome P450 3A4enzyme
DB01104SertralineAmine oxidase [flavin-containing] Benzyme
DB01104SertralineAmine oxidase [flavin-containing] Aenzyme
DB01104SertralineMultidrug resistance protein 1transporter
DB01104SertralineCytochrome P450 1A2enzyme
DB01104SertralineSerum albumincarrier
DB01104SertralineSigma receptortarget
DB00656Trazodone5-hydroxytryptamine receptor 2Atarget
DB00656TrazodoneSodium-dependent serotonin transportertarget
DB00656TrazodoneAlpha-1A adrenergic receptortarget
DB00656TrazodoneAlpha-2A adrenergic receptortarget
DB00656TrazodoneHistamine H1 receptortarget
DB00656Trazodone5-hydroxytryptamine receptor 1Atarget
DB00656TrazodoneCytochrome P450 2D6enzyme
DB00656TrazodoneCytochrome P450 3A4enzyme
DB00656Trazodone5-hydroxytryptamine receptor 2Ctarget
DB00656TrazodoneAlpha-1-acid glycoprotein 1carrier
DB00656TrazodoneCytochrome P450 3A5enzyme
DB00656TrazodoneCytochrome P450 3A7enzyme
DB00656TrazodoneMultidrug resistance protein 1transporter
DB00285VenlafaxineSodium-dependent serotonin transportertarget
DB00285VenlafaxineSodium-dependent noradrenaline transportertarget
DB00285VenlafaxineCytochrome P450 2D6enzyme
DB00285VenlafaxineCytochrome P450 3A4enzyme
DB00285VenlafaxineCytochrome P450 2C9enzyme
DB00285VenlafaxineCytochrome P450 2C19enzyme
DB00285VenlafaxineSodium-dependent dopamine transportertarget
DB00285VenlafaxineMultidrug resistance protein 1transporter
DB00285VenlafaxineCytochrome P450 2B6enzyme
DB00285VenlafaxineATP-binding cassette sub-family G member 2transporter
DB06684Vilazodone5-hydroxytryptamine receptor 1Atarget
DB06684VilazodoneCytochrome P450 3A4enzyme
DB06684VilazodoneCytochrome P450 2C18enzyme
DB06684VilazodoneCytochrome P450 2D6enzyme
DB06684VilazodoneSodium-dependent serotonin transportertransporter
DB09068VortioxetineSodium-dependent serotonin transportertarget
DB09068Vortioxetine5-hydroxytryptamine receptor 3Atarget
DB09068Vortioxetine5-hydroxytryptamine receptor 7target
DB09068Vortioxetine5-hydroxytryptamine receptor 1Btarget
DB09068Vortioxetine5-hydroxytryptamine receptor 1Atarget
DB09068VortioxetineBeta-1 adrenergic receptortarget
DB09068Vortioxetinesolute carrier family 6 member 2target
DB09068VortioxetineCytochrome P450 2D6enzyme
DB09068VortioxetineCytochrome P450 3A4enzyme
DB09068VortioxetineCytochrome P450 3A5enzyme
DB09068VortioxetineCytochrome P450 2C19enzyme
DB09068VortioxetineCytochrome P450 2C9enzyme
DB09068VortioxetineCytochrome P450 2A6enzyme
DB09068VortioxetineCytochrome P450 2C8enzyme
DB09068VortioxetineCytochrome P450 2B6enzyme
DrugDrug NamePhaseStatusCount
DB06151Acetylcysteine0Recruiting1
DB00482Celecoxib0Recruiting1
DB00215Citalopram0Completed1
DB00215Citalopram0Recruiting1
DB01221Ketamine0Completed1
DB00683Midazolam0Completed1
DB01017Minocycline0Recruiting1
DB00370Mirtazapine0Completed1
DB10803Salmonella typhi ty2 vi polysaccharide antigen0Completed1
DB01104Sertraline0Recruiting1
DB09068Vortioxetine0Withdrawn1
DB09278Activated charcoal1Completed1
DB06288Amisulpride1Completed2
DB09128Brexpiprazole1Completed1
DB01156Bupropion1Completed2
DB12063CERC-3011Completed1
DB05205CX1571Completed1
DB01211Clarithromycin1Completed1
DB00758Clopidogrel1Completed1
DB00318Codeine1Completed1
DB00260Cycloserine1Not Yet Recruiting1
DB06700Desvenlafaxine1Completed4
DB00514Dextromethorphan1Not Yet Recruiting1
DB00390Digoxin1Completed1
DB01075Diphenhydramine1Completed1
DB00476Duloxetine1Completed1
DB00476Duloxetine1Recruiting1
DB09184Edivoxetine1Completed15
DB01175Escitalopram1Completed2
DB01175Escitalopram1Recruiting1
DB11823Esketamine1Recruiting1
DB00977Ethinyl Estradiol1Completed1
DB00472Fluoxetine1Completed2
DB12542GSK-3562781Completed1
DB01221Ketamine1Completed1
DB01221Ketamine1Enrolling by Invitation1
DB01221Ketamine1Not Yet Recruiting1
DB01221Ketamine1Recruiting3
DB01009Ketoprofen1Completed1
DB01356Lithium1Completed2
DB00186Lorazepam1Completed1
DB01043Memantine1Completed1
DB00683Midazolam1Recruiting1
DB11784NRX-10741Completed1
DB06690Nitrous oxide1Recruiting1
DB00957Norgestimate1Completed1
DB00107Oxytocin1Unknown Status1
DB00715Paroxetine1Completed1
DB08883Perampanel1Not Yet Recruiting1
DB00818Propofol1Active Not Recruiting1
DB00571Propranolol1Completed1
DB00908Quinidine1Completed1
DB01954Rolipram1Completed1
DB01001Salbutamol1Completed1
DB01104Sertraline1Completed3
DB00277Theophylline1Completed1
DB09070Tibolone1Unknown Status1
DB00682Warfarin1Completed1
DB01593Zinc1Completed1
DB00921Buprenorphine1 / 2Active Not Recruiting1
DB00921Buprenorphine1 / 2Completed1
DB00921Buprenorphine1 / 2Recruiting1
DB01175Escitalopram1 / 2Completed1
DB01221Ketamine1 / 2Recruiting1
DB01221Ketamine1 / 2Unknown Status1
DB01356Lithium1 / 2Recruiting1
DB01183Naloxone1 / 2Active Not Recruiting1
DB01183Naloxone1 / 2Recruiting1
DB00704Naltrexone1 / 2Recruiting1
DB12572Pexacerfont1 / 2Completed1
DB01104Sertraline1 / 2Recruiting1
DB00285Venlafaxine1 / 2Active Not Recruiting1
DB00285Venlafaxine1 / 2Recruiting1
DB12878AV-1012Recruiting2
DB12644AZD-20662Terminated1
DB00321Amitriptyline2Completed1
DB01238Aripiprazole2Completed1
DB11833Basimglurant2Completed1
DB00083Botulinum Toxin Type A2Completed1
DB09128Brexpiprazole2Completed3
DB01156Bupropion2Active Not Recruiting1
DB01156Bupropion2Completed1
DB00490Buspirone2Completed1
DB12063CERC-3012Completed2
DB12244CP-6019272Terminated1
DB05205CX1572Completed1
DB06016Cariprazine2Completed2
DB06634Casopitant2Completed2
DB05095Cimicoxib2Completed1
DB00215Citalopram2Active Not Recruiting2
DB00215Citalopram2Completed4
DB00766Clavulanate2Completed2
DB00260Cycloserine2Completed2
DB00260Cycloserine2Not Yet Recruiting1
DB00260Cycloserine2Recruiting1
DB05954Dasotraline2Completed1
DB11923Decoglurant2Completed1
DB11923Decoglurant2Withdrawn1
DB06700Desvenlafaxine2Completed1
DB11807Dexmecamylamine2Completed1
DB11807Dexmecamylamine2Terminated1
DB00514Dextromethorphan2Completed1
DB00476Duloxetine2Active Not Recruiting1
DB00476Duloxetine2Completed4
DB00476Duloxetine2Terminated2
DB09184Edivoxetine2Completed2
DB01175Escitalopram2Active Not Recruiting1
DB01175Escitalopram2Completed11
DB01175Escitalopram2Not Yet Recruiting1
DB01175Escitalopram2Terminated1
DB11823Esketamine2Completed2
DB11823Esketamine2Recruiting1
DB04953Ezogabine2Completed1
DB00472Fluoxetine2Completed3
DB00472Fluoxetine2Terminated1
DB06554Gaboxadol2Completed1
DB00159Icosapent2Completed1
DB12059JNJ-404118132Completed1
DB01322Kava2Completed1
DB01221Ketamine2Active Not Recruiting1
DB01221Ketamine2Completed3
DB01221Ketamine2Enrolling by Invitation1
DB01221Ketamine2Recruiting3
DB01221Ketamine2Terminated3
DB00149L-Leucine2Recruiting1
DB11889Lanicemine2Completed1
DB08918Levomilnacipran2Completed1
DB01255Lisdexamfetamine2Completed3
DB01356Lithium2Completed1
DB12270Losmapimod2Completed1
DB12270Losmapimod2Terminated1
DB00657Mecamylamine2Completed2
DB01011Metyrapone2Completed1
DB00683Midazolam2Completed1
DB00683Midazolam2Recruiting1
DB01017Minocycline2Recruiting1
DB00370Mirtazapine2Active Not Recruiting2
DB00370Mirtazapine2Recruiting1
DB00745Modafinil2Recruiting1
DB11784NRX-10742Completed1
DB00704Naltrexone2Completed1
DB05562Naluzotan2Completed1
DB12643Nelivaptan2Completed1
DB06690Nitrous oxide2Active Not Recruiting1
DB06690Nitrous oxide2Recruiting1
DB00540Nortriptyline2Active Not Recruiting1
DB05423ORG-345172Completed1
DB11133Omega-3 fatty acids2Completed2
DB11133Omega-3 fatty acids2Unknown Status2
DB12427Orvepitant2Terminated1
DB00715Paroxetine2Active Not Recruiting1
DB00715Paroxetine2Completed3
DB00806Pentoxifylline2Completed1
DB00960Pindolol2Completed1
DB01132Pioglitazone2Completed1
DB00413Pramipexole2Completed1
DB02789Pregnenolone2Withdrawn1
DB11664Psilocybine2Not Yet Recruiting1
DB11664Psilocybine2Recruiting1
DB01224Quetiapine2Completed2
DB01224Quetiapine2Suspended1
DB01224Quetiapine2Withdrawn1
DB00908Quinidine2Completed1
DB11790Radafaxine2Completed3
DB11801Rapastinel2Active Not Recruiting1
DB11801Rapastinel2Completed2
DB11801Rapastinel2Recruiting1
DB00740Riluzole2Recruiting1
DB12519Sarcosine2Completed1
DB01104Sertraline2Active Not Recruiting1
DB01104Sertraline2Completed4
DB01104Sertraline2Recruiting2
DB01104Sertraline2Terminated1
DB11803Sirukumab2Recruiting1
DB09153Sodium Chloride2Active Not Recruiting1
DB01323St. John's Wort2Completed1
DB12641Tedatioxetine2Completed1
DB06273Tocilizumab2Recruiting1
DB00285Venlafaxine2Active Not Recruiting1
DB00285Venlafaxine2Completed3
DB00285Venlafaxine2Terminated1
DB06684Vilazodone2Completed2
DB05700Vortioxetine2Completed3
DB09068Vortioxetine2Completed4
DB00246Ziprasidone2Completed2
DB00475Chlordiazepoxide2 / 3Completed1
DB00215Citalopram2 / 3Completed1
DB06700Desvenlafaxine2 / 3Terminated1
DB09184Edivoxetine2 / 3Completed1
DB01175Escitalopram2 / 3Completed1
DB01175Escitalopram2 / 3Recruiting1
DB13961Fish oil2 / 3Completed1
DB01050Ibuprofen2 / 3Completed1
DB00159Icosapent2 / 3Recruiting1
DB01221Ketamine2 / 3Recruiting2
DB01221Ketamine2 / 3Unknown Status1
DB01043Memantine2 / 3Completed1
DB00834Mifepristone2 / 3Terminated1
DB01132Pioglitazone2 / 3Completed1
DB01104Sertraline2 / 3Completed1
DB09071Tasimelteon2 / 3Completed1
DB05700Vortioxetine2 / 3Completed1
DB09068Vortioxetine2 / 3Completed1
DB09068Vortioxetine2 / 3Not Yet Recruiting1
DB06594Agomelatine3Completed7
DB06594Agomelatine3Terminated1
DB05395Amibegron3Completed4
DB00321Amitriptyline3Completed1
DB00673Aprepitant3Completed9
DB01238Aripiprazole3Completed8
DB01238Aripiprazole3Terminated3
DB09128Brexpiprazole3Completed10
DB09128Brexpiprazole3Terminated2
DB00921Buprenorphine3Active Not Recruiting1
DB00921Buprenorphine3Completed1
DB01156Bupropion3Completed6
DB06016Cariprazine3Completed2
DB11121Chloroxylenol3Recruiting1
DB00215Citalopram3Completed3
DB00215Citalopram3Withdrawn1
DB01151Desipramine3Completed1
DB06700Desvenlafaxine3Completed5
DB06700Desvenlafaxine3Unknown Status1
DB11807Dexmecamylamine3Completed5
DB00476Duloxetine3Completed19
DB00476Duloxetine3Not Yet Recruiting1
DB09184Edivoxetine3Completed6
DB01240Epoprostenol3Completed1
DB01175Escitalopram3Completed15
DB01175Escitalopram3Terminated4
DB01175Escitalopram3Unknown Status1
DB11823Esketamine3Recruiting2
DB00402Eszopiclone3Completed2
DB00472Fluoxetine3Completed10
DB00472Fluoxetine3Recruiting4
DB00674Galantamine3Completed1
DB09341Glucose3Completed1
DB12551Idazoxan3Withdrawn1
DB01221Ketamine3Active Not Recruiting1
DB01221Ketamine3Completed1
DB01221Ketamine3Enrolling by Invitation1
DB00650Leucovorin3Completed1
DB08918Levomilnacipran3Completed4
DB08918Levomilnacipran3Recruiting3
DB00279Liothyronine3Completed1
DB06655Liraglutide3Completed1
DB01255Lisdexamfetamine3Completed2
DB01255Lisdexamfetamine3Terminated1
DB01356Lithium3Completed1
DB01356Lithium3Terminated1
DB08815Lurasidone3Completed1
DB08815Lurasidone3Withdrawn1
DB00422Methylphenidate3Completed1
DB00834Mifepristone3Completed5
DB00834Mifepristone3Unknown Status1
DB01183Naloxone3Active Not Recruiting1
DB01183Naloxone3Completed1
DB00334Olanzapine3Completed1
DB00715Paroxetine3Completed12
DB00715Paroxetine3Terminated1
DB09286Pipamperone3Completed1
DB00205Pyrimethamine3Completed1
DB01224Quetiapine3Completed9
DB01224Quetiapine3Recruiting1
DB01224Quetiapine3Terminated1
DB00980Ramelteon3Terminated1
DB11801Rapastinel3Recruiting5
DB00734Risperidone3Completed2
DB00734Risperidone3Unknown Status1
DB06660Saredutant3Completed2
DB08839Serotonin3Completed1
DB01104Sertraline3Completed4
DB00641Simvastatin3Not Yet Recruiting1
DB09153Sodium Chloride3Active Not Recruiting1
DB00656Trazodone3Completed2
DB00285Venlafaxine3Completed10
DB06684Vilazodone3Active Not Recruiting1
DB06684Vilazodone3Completed5
DB06684Vilazodone3Recruiting1
DB05700Vortioxetine3Active Not Recruiting1
DB09068Vortioxetine3Active Not Recruiting1
DB05700Vortioxetine3Completed21
DB09068Vortioxetine3Completed22
DB05700Vortioxetine3Enrolling by Invitation2
DB09068Vortioxetine3Enrolling by Invitation2
DB05700Vortioxetine3Recruiting2
DB09068Vortioxetine3Recruiting2
DB09068Vortioxetine3Withdrawn1
DB00246Ziprasidone3Completed1
DB00659Acamprosate4Completed2
DB06594Agomelatine4Unknown Status1
DB00321Amitriptyline4Unknown Status1
DB13114Amitriptylinoxide4Unknown Status1
DB00182Amphetamine4Completed1
DB01238Aripiprazole4Completed4
DB01238Aripiprazole4Recruiting3
DB01238Aripiprazole4Terminated1
DB01238Aripiprazole4Withdrawn1
DB06413Armodafinil4Completed1
DB00083Botulinum Toxin Type A4Unknown Status1
DB01156Bupropion4Completed8
DB01156Bupropion4Not Yet Recruiting1
DB01156Bupropion4Recruiting4
DB01156Bupropion4Terminated1
DB01156Bupropion4Unknown Status2
DB01156Bupropion4Withdrawn1
DB00490Buspirone4Recruiting1
DB00215Citalopram4Completed5
DB00215Citalopram4Recruiting1
DB00215Citalopram4Unknown Status3
DB00215Citalopram4Withdrawn1
DB00148Creatine4Active Not Recruiting1
DB00148Creatine4Completed1
DB00148Creatine4Recruiting1
DB00148Creatine4Withdrawn1
DB11672Curcumin4Completed1
DB01151Desipramine4Completed1
DB06700Desvenlafaxine4Completed3
DB06700Desvenlafaxine4Terminated1
DB06700Desvenlafaxine4Unknown Status2
DB01576Dextroamphetamine4Completed1
DB01576Dextroamphetamine4Terminated1
DB00476Duloxetine4Completed24
DB00476Duloxetine4Recruiting2
DB00476Duloxetine4Unknown Status3
DB01175Escitalopram4Active Not Recruiting3
DB01175Escitalopram4Completed28
DB01175Escitalopram4Recruiting10
DB01175Escitalopram4Terminated3
DB01175Escitalopram4Unknown Status8
DB00783Estradiol4Unknown Status1
DB00402Eszopiclone4Unknown Status1
DB00472Fluoxetine4Completed10
DB00472Fluoxetine4Recruiting1
DB00472Fluoxetine4Unknown Status4
DB00176Fluvoxamine4Completed2
DB00176Fluvoxamine4Unknown Status2
DB04946Iloperidone4Completed1
DB00458Imipramine4Completed3
DB01221Ketamine4Completed4
DB01221Ketamine4Recruiting3
DB00125L-Arginine4Unknown Status1
DB00555Lamotrigine4Completed1
DB00555Lamotrigine4Terminated1
DB08918Levomilnacipran4Active Not Recruiting1
DB08918Levomilnacipran4Recruiting1
DB00279Liothyronine4Completed1
DB00279Liothyronine4Terminated1
DB01255Lisdexamfetamine4Completed1
DB01356Lithium4Completed3
DB01356Lithium4Recruiting2
DB01356Lithium4Terminated1
DB00678Losartan4Recruiting1
DB00683Midazolam4Completed2
DB00683Midazolam4Recruiting1
DB00370Mirtazapine4Completed5
DB00370Mirtazapine4Recruiting2
DB00370Mirtazapine4Terminated1
DB00370Mirtazapine4Unknown Status2
DB00745Modafinil4Completed1
DB00184Nicotine4Completed1
DB00184Nicotine4Unknown Status1
DB00540Nortriptyline4Recruiting1
DB00540Nortriptyline4Terminated1
DB00540Nortriptyline4Unknown Status1
DB00334Olanzapine4Completed1
DB01267Paliperidone4Completed1
DB00715Paroxetine4Completed7
DB00715Paroxetine4Terminated1
DB00715Paroxetine4Unknown Status3
DB01132Pioglitazone4Unknown Status1
DB00413Pramipexole4Active Not Recruiting1
DB02789Pregnenolone4Completed2
DB02789Pregnenolone4Not Yet Recruiting1
DB01224Quetiapine4Active Not Recruiting1
DB01224Quetiapine4Completed5
DB01224Quetiapine4Recruiting1
DB01224Quetiapine4Terminated1
DB01224Quetiapine4Unknown Status1
DB00980Ramelteon4Completed1
DB00234Reboxetine4Unknown Status1
DB00740Riluzole4Completed1
DB00734Risperidone4Terminated1
DB00268Ropinirole4Unknown Status1
DB00747Scopolamine4Recruiting1
DB01037Selegiline4Completed1
DB01104Sertraline4Completed8
DB01104Sertraline4Recruiting3
DB01104Sertraline4Terminated2
DB01104Sertraline4Unknown Status3
DB01236Sevoflurane4Completed1
DB00641Simvastatin4Recruiting1
DB09153Sodium Chloride4Recruiting3
DB09153Sodium Chloride4Unknown Status1
DB09034Suvorexant4Not Yet Recruiting1
DB00624Testosterone4Completed1
DB09289Tianeptine4Completed1
DB00752Tranylcypromine4Terminated2
DB00656Trazodone4Unknown Status1
DB00726Trimipramine4Unknown Status1
DB00177Valsartan4Unknown Status1
DB01273Varenicline4Recruiting1
DB00285Venlafaxine4Completed10
DB00285Venlafaxine4Recruiting4
DB00285Venlafaxine4Terminated1
DB00285Venlafaxine4Unknown Status4
DB00285Venlafaxine4Withdrawn1
DB06684Vilazodone4Completed5
DB06684Vilazodone4Terminated1
DB06684Vilazodone4Withdrawn1
DB09068Vortioxetine4Active Not Recruiting1
DB09068Vortioxetine4Completed2
DB09068Vortioxetine4Not Yet Recruiting1
DB09068Vortioxetine4Recruiting4
DB06151AcetylcysteineNot AvailableRecruiting1
DB06594AgomelatineNot AvailableCompleted1
DB06594AgomelatineNot AvailableWithdrawn1
DB00182AmphetamineNot AvailableUnknown Status1
DB01238AripiprazoleNot AvailableCompleted2
DB01238AripiprazoleNot AvailableUnknown Status1
DB00921BuprenorphineNot AvailableNot Yet Recruiting1
DB01156BupropionNot AvailableActive Not Recruiting1
DB01156BupropionNot AvailableCompleted1
DB01156BupropionNot AvailableUnknown Status1
DB00215CitalopramNot AvailableCompleted3
DB12153CiticolineNot AvailableCompleted1
DB01242ClomipramineNot AvailableCompleted1
DB00260CycloserineNot AvailableRecruiting1
DB00847CysteamineNot AvailableTerminated1
DB06700DesvenlafaxineNot AvailableCompleted1
DB06700DesvenlafaxineNot AvailableNot Yet Recruiting1
DB01576DextroamphetamineNot AvailableUnknown Status1
DB00476DuloxetineNot AvailableActive Not Recruiting1
DB00476DuloxetineNot AvailableCompleted3
DB00476DuloxetineNot AvailableNo Longer Available1
DB00476DuloxetineNot AvailableTerminated1
DB00476DuloxetineNot AvailableUnknown Status2
DB00476DuloxetineNot AvailableWithdrawn1
DB01175EscitalopramNot AvailableActive Not Recruiting1
DB01175EscitalopramNot AvailableCompleted8
DB01175EscitalopramNot AvailableRecruiting2
DB01175EscitalopramNot AvailableUnknown Status4
DB00292EtomidateNot AvailableCompleted1
DB09149Florbetapir (18F)Not AvailableRecruiting1
DB00687FludrocortisoneNot AvailableCompleted1
DB00687FludrocortisoneNot AvailableRecruiting1
DB00472FluoxetineNot AvailableActive Not Recruiting1
DB00472FluoxetineNot AvailableCompleted6
DB00472FluoxetineNot AvailableTerminated1
DB00472FluoxetineNot AvailableUnknown Status1
DB05087GanaxoloneNot AvailableRecruiting1
DB11895GhrelinNot AvailableCompleted1
DB00014GoserelinNot AvailableCompleted1
DB00741HydrocortisoneNot AvailableCompleted1
DB00741HydrocortisoneNot AvailableUnknown Status1
DB01064IsoprenalineNot AvailableRecruiting1
DB01221KetamineNot AvailableActive Not Recruiting1
DB01221KetamineNot AvailableCompleted4
DB01221KetamineNot AvailableNot Yet Recruiting1
DB01221KetamineNot AvailableRecruiting2
DB01221KetamineNot AvailableTerminated2
DB01221KetamineNot AvailableWithdrawn1
DB01235LevodopaNot AvailableRecruiting1
DB11256Levomefolic acidNot AvailableCompleted1
DB00279LiothyronineNot AvailableCompleted2
DB01356LithiumNot AvailableRecruiting1
DB00186LorazepamNot AvailableCompleted1
DB01043MemantineNot AvailableUnknown Status1
DB01043MemantineNot AvailableWithdrawn1
DB00474MethohexitalNot AvailableActive Not Recruiting1
DB00474MethohexitalNot AvailableTerminated1
DB00683MidazolamNot AvailableRecruiting1
DB04896MilnacipranNot AvailableUnknown Status1
DB00370MirtazapineNot AvailableRecruiting1
DB00370MirtazapineNot AvailableUnknown Status1
DB00107OxytocinNot AvailableTerminated1
DB00715ParoxetineNot AvailableActive Not Recruiting1
DB00715ParoxetineNot AvailableCompleted1
DB00715ParoxetineNot AvailableUnknown Status1
DB00008Peginterferon alfa-2aNot AvailableCompleted1
DB00960PindololNot AvailableTerminated1
DB00818PropofolNot AvailableCompleted3
DB01224QuetiapineNot AvailableCompleted2
DB00234ReboxetineNot AvailableCompleted1
DB00811RibavirinNot AvailableCompleted1
DB00747ScopolamineNot AvailableWithdrawn1
DB08839SerotoninNot AvailableCompleted1
DB01104SertralineNot AvailableCompleted8
DB01104SertralineNot AvailableRecruiting2
DB01104SertralineNot AvailableUnknown Status1
DB09153Sodium ChlorideNot AvailableCompleted1
DB09153Sodium ChlorideNot AvailableRecruiting1
DB09072Sodium oxybateNot AvailableCompleted1
DB00421SpironolactoneNot AvailableCompleted1
DB01323St. John's WortNot AvailableCompleted1
DB11471TilmicosinNot AvailableUnknown Status1
DB00285VenlafaxineNot AvailableActive Not Recruiting1
DB00285VenlafaxineNot AvailableCompleted3
DB00285VenlafaxineNot AvailableUnknown Status3
DB01392YohimbineNot AvailableRecruiting1