Promestriene

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Promestriene
Accession Number
DB12487
Type
Small Molecule
Groups
Investigational
Description

Promestriene has been used in trials studying the prevention of Hypospadias.

Synonyms
Not Available
Categories
UNII
GXM4PER6WZ
CAS number
39219-28-8
Weight
Not Available
Chemical Formula
Not Available
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
16-BromoepiandrosteroneThe serum concentration of 16-Bromoepiandrosterone can be increased when it is combined with Promestriene.Investigational
19-norandrostenedioneThe serum concentration of 19-norandrostenedione can be increased when it is combined with Promestriene.Experimental, Illicit
5-androstenedioneThe serum concentration of 5-androstenedione can be increased when it is combined with Promestriene.Experimental, Illicit
AbciximabPromestriene may decrease the anticoagulant activities of Abciximab.Approved
AceclofenacAceclofenac may increase the thrombogenic activities of Promestriene.Approved, Investigational
AcenocoumarolPromestriene may decrease the anticoagulant activities of Acenocoumarol.Approved, Investigational
Acetylsalicylic acidAcetylsalicylic acid may increase the thrombogenic activities of Promestriene.Approved, Vet Approved
AlclometasoneThe serum concentration of Alclometasone can be increased when it is combined with Promestriene.Approved
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Promestriene.Experimental, Investigational
Ambroxol acefyllinateThe serum concentration of Ambroxol acefyllinate can be increased when it is combined with Promestriene.Experimental, Investigational
AmcinonideThe serum concentration of Amcinonide can be increased when it is combined with Promestriene.Approved
AminophyllineThe serum concentration of Aminophylline can be increased when it is combined with Promestriene.Approved
Aminosalicylic AcidAminosalicylic Acid may increase the thrombogenic activities of Promestriene.Approved
AnastrozoleThe therapeutic efficacy of Anastrozole can be decreased when used in combination with Promestriene.Approved, Investigational
AncrodPromestriene may decrease the anticoagulant activities of Ancrod.Approved, Investigational
AndrostenedioneThe serum concentration of Androstenedione can be increased when it is combined with Promestriene.Experimental, Illicit
AnecortaveThe serum concentration of Anecortave can be increased when it is combined with Promestriene.Investigational
anecortave acetateThe serum concentration of anecortave acetate can be increased when it is combined with Promestriene.Investigational
Anthrax immune globulin humanPromestriene may increase the thrombogenic activities of Anthrax immune globulin human.Approved
AntipyrineAntipyrine may increase the thrombogenic activities of Promestriene.Approved, Investigational
Antithrombin III humanPromestriene may decrease the anticoagulant activities of Antithrombin III human.Approved
AntrafenineAntrafenine may increase the thrombogenic activities of Promestriene.Approved
ApixabanPromestriene may decrease the anticoagulant activities of Apixaban.Approved
ArdeparinPromestriene may decrease the anticoagulant activities of Ardeparin.Approved, Investigational, Withdrawn
ArgatrobanPromestriene may decrease the anticoagulant activities of Argatroban.Approved, Investigational
Ascorbic acidThe serum concentration of Promestriene can be increased when it is combined with Vitamin C.Approved, Nutraceutical
AtamestaneThe serum concentration of Atamestane can be increased when it is combined with Promestriene.Investigational
BalsalazideBalsalazide may increase the thrombogenic activities of Promestriene.Approved, Investigational
BecaplerminPromestriene may decrease the anticoagulant activities of Becaplermin.Approved, Investigational
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Promestriene.Approved, Vet Approved
BivalirudinPromestriene may decrease the anticoagulant activities of Bivalirudin.Approved, Investigational
BromfenacBromfenac may increase the thrombogenic activities of Promestriene.Approved
BufexamacBufexamac may increase the thrombogenic activities of Promestriene.Approved, Experimental
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Promestriene.Approved
Capromab pendetidePromestriene may decrease effectiveness of Capromab pendetide as a diagnostic agent.Approved
CapsaicinCapsaicin may increase the thrombogenic activities of Promestriene.Approved
CarprofenCarprofen may increase the thrombogenic activities of Promestriene.Approved, Vet Approved, Withdrawn
CelecoxibCelecoxib may increase the thrombogenic activities of Promestriene.Approved, Investigational
CertoparinPromestriene may decrease the anticoagulant activities of Certoparin.Approved, Investigational
Chenodeoxycholic acidThe therapeutic efficacy of Chenodeoxycholic acid can be decreased when used in combination with Promestriene.Approved
ChlorphenesinChlorphenesin may increase the thrombogenic activities of Promestriene.Approved, Vet Approved, Withdrawn
Choline magnesium trisalicylateCholine magnesium trisalicylate may increase the thrombogenic activities of Promestriene.Approved
CiclesonideThe serum concentration of Ciclesonide can be increased when it is combined with Promestriene.Approved, Investigational
CimicoxibCimicoxib may increase the thrombogenic activities of Promestriene.Investigational
CisplatinCisplatin may increase the thrombogenic activities of Promestriene.Approved
ClobetasolThe serum concentration of Clobetasol can be increased when it is combined with Promestriene.Approved, Investigational
Clobetasol propionateThe serum concentration of Clobetasol propionate can be increased when it is combined with Promestriene.Approved
ClobetasoneThe serum concentration of Clobetasone can be increased when it is combined with Promestriene.Approved
ClocortoloneThe serum concentration of Clocortolone can be increased when it is combined with Promestriene.Approved
Clodronic AcidClodronic Acid may increase the thrombogenic activities of Promestriene.Approved, Investigational, Vet Approved
Conestat alfaPromestriene may increase the thrombogenic activities of Conestat alfa.Approved, Investigational
Cortexolone 17α-propionateThe serum concentration of Cortexolone 17α-propionate can be increased when it is combined with Promestriene.Investigational
CorticosteroneThe serum concentration of Corticosterone can be increased when it is combined with Promestriene.Experimental
Cortisone acetateThe serum concentration of Cortisone acetate can be increased when it is combined with Promestriene.Approved, Investigational
Dabigatran etexilatePromestriene may decrease the anticoagulant activities of Dabigatran etexilate.Approved
DalteparinPromestriene may decrease the anticoagulant activities of Dalteparin.Approved
DanaparoidPromestriene may decrease the anticoagulant activities of Danaparoid.Approved, Withdrawn
DarexabanPromestriene may decrease the anticoagulant activities of Darexaban.Investigational
DeflazacortThe serum concentration of Deflazacort can be increased when it is combined with Promestriene.Approved, Investigational
DesirudinPromestriene may decrease the anticoagulant activities of Desirudin.Approved
DesonideThe serum concentration of Desonide can be increased when it is combined with Promestriene.Approved, Investigational
DesoximetasoneThe serum concentration of Desoximetasone can be increased when it is combined with Promestriene.Approved
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be increased when it is combined with Promestriene.Approved
Desoxycorticosterone PivalateThe serum concentration of Desoxycorticosterone Pivalate can be increased when it is combined with Promestriene.Experimental, Vet Approved
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be increased when it is combined with Promestriene.Vet Approved
DexibuprofenDexibuprofen may increase the thrombogenic activities of Promestriene.Approved, Investigational
DexketoprofenDexketoprofen may increase the thrombogenic activities of Promestriene.Approved, Investigational
DextranPromestriene may decrease the anticoagulant activities of Dextran.Approved, Investigational, Vet Approved
DicoumarolPromestriene may decrease the anticoagulant activities of Dicoumarol.Approved
DiflorasoneThe serum concentration of Diflorasone can be increased when it is combined with Promestriene.Approved
DiflunisalDiflunisal may increase the thrombogenic activities of Promestriene.Approved, Investigational
DifluocortoloneThe serum concentration of Difluocortolone can be increased when it is combined with Promestriene.Approved, Investigational, Withdrawn
DifluprednateThe serum concentration of Difluprednate can be increased when it is combined with Promestriene.Approved
DrospirenoneDrospirenone may increase the thrombogenic activities of Promestriene.Approved
DroxicamDroxicam may increase the thrombogenic activities of Promestriene.Withdrawn
DyphyllineThe serum concentration of Dyphylline can be increased when it is combined with Promestriene.Approved
Edetic AcidPromestriene may decrease the anticoagulant activities of Edetic Acid.Approved, Vet Approved
EdoxabanPromestriene may decrease the anticoagulant activities of Edoxaban.Approved
EnoxaparinPromestriene may decrease the anticoagulant activities of Enoxaparin.Approved
EquileninThe serum concentration of Equilenin can be increased when it is combined with Promestriene.Experimental
EquilinThe serum concentration of Equilin can be increased when it is combined with Promestriene.Approved
EstroneThe serum concentration of Estrone can be increased when it is combined with Promestriene.Approved
Estrone sulfateThe serum concentration of Estrone sulfate can be increased when it is combined with Promestriene.Approved
EtanerceptEtanercept may increase the thrombogenic activities of Promestriene.Approved, Investigational
Ethyl biscoumacetatePromestriene may decrease the anticoagulant activities of Ethyl biscoumacetate.Withdrawn
EtodolacEtodolac may increase the thrombogenic activities of Promestriene.Approved, Investigational, Vet Approved
EtoricoxibEtoricoxib may increase the thrombogenic activities of Promestriene.Approved, Investigational
ExemestaneThe therapeutic efficacy of Exemestane can be decreased when used in combination with Promestriene.Approved, Investigational
FenoprofenFenoprofen may increase the thrombogenic activities of Promestriene.Approved
Ferulic acidPromestriene may decrease the anticoagulant activities of Ferulic acid.Experimental
FluasteroneThe serum concentration of Fluasterone can be increased when it is combined with Promestriene.Investigational
FludrocortisoneThe serum concentration of Fludrocortisone can be increased when it is combined with Promestriene.Approved, Investigational
FluindionePromestriene may decrease the anticoagulant activities of Fluindione.Approved, Investigational
FlumethasoneThe serum concentration of Flumethasone can be increased when it is combined with Promestriene.Approved, Vet Approved
FlunisolideThe serum concentration of Flunisolide can be increased when it is combined with Promestriene.Approved, Investigational
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be increased when it is combined with Promestriene.Approved, Investigational, Vet Approved
FluocinonideThe serum concentration of Fluocinonide can be increased when it is combined with Promestriene.Approved, Investigational
FluocortoloneThe serum concentration of Fluocortolone can be increased when it is combined with Promestriene.Approved, Withdrawn
FluorometholoneThe serum concentration of Fluorometholone can be increased when it is combined with Promestriene.Approved, Investigational
FluprednideneThe serum concentration of Fluprednidene can be increased when it is combined with Promestriene.Approved, Withdrawn
FluprednisoloneThe serum concentration of Fluprednisolone can be increased when it is combined with Promestriene.Approved
FlurandrenolideThe serum concentration of Flurandrenolide can be increased when it is combined with Promestriene.Approved
FlurbiprofenFlurbiprofen may increase the thrombogenic activities of Promestriene.Approved, Investigational
FluticasoneThe serum concentration of Fluticasone can be increased when it is combined with Promestriene.Approved, Experimental, Investigational
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Promestriene.Approved
FondaparinuxPromestriene may decrease the anticoagulant activities of Fondaparinux sodium.Approved, Investigational
FormestaneThe serum concentration of Formestane can be increased when it is combined with Promestriene.Approved, Investigational, Withdrawn
GabexatePromestriene may decrease the anticoagulant activities of Gabexate.Investigational
GanciclovirThe serum concentration of Ganciclovir can be increased when it is combined with Promestriene.Approved, Investigational
GinsengGinseng may increase the thrombogenic activities of Promestriene.Approved, Investigational, Nutraceutical
HalcinonideThe serum concentration of Halcinonide can be increased when it is combined with Promestriene.Approved, Investigational, Withdrawn
HE3286The serum concentration of HE3286 can be increased when it is combined with Promestriene.Investigational
HeparinPromestriene may decrease the anticoagulant activities of Heparin.Approved, Investigational
Human C1-esterase inhibitorPromestriene may increase the thrombogenic activities of Human C1-esterase inhibitor.Approved
HyaluronidaseThe therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Promestriene.Approved, Investigational
IcosapentIcosapent may increase the thrombogenic activities of Promestriene.Approved, Nutraceutical
IdraparinuxPromestriene may decrease the anticoagulant activities of Idraparinux.Investigational
IndomethacinIndomethacin may increase the thrombogenic activities of Promestriene.Approved, Investigational
IstaroximeThe serum concentration of Istaroxime can be increased when it is combined with Promestriene.Investigational
KetoprofenKetoprofen may increase the thrombogenic activities of Promestriene.Approved, Vet Approved
LenalidomidePromestriene may increase the thrombogenic activities of Lenalidomide.Approved
LepirudinPromestriene may decrease the anticoagulant activities of Lepirudin.Approved
LetaxabanPromestriene may decrease the anticoagulant activities of Letaxaban.Investigational
LevothyroxineThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Promestriene.Approved
LiothyronineThe therapeutic efficacy of Liothyronine can be decreased when used in combination with Promestriene.Approved, Vet Approved
LiotrixThe therapeutic efficacy of Liotrix can be decreased when used in combination with Promestriene.Approved
LornoxicamLornoxicam may increase the thrombogenic activities of Promestriene.Approved, Investigational
LoteprednolThe serum concentration of Loteprednol can be increased when it is combined with Promestriene.Approved
LumiracoxibLumiracoxib may increase the thrombogenic activities of Promestriene.Approved, Investigational
Magnesium salicylateMagnesium salicylate may increase the thrombogenic activities of Promestriene.Approved
ME-609The serum concentration of ME-609 can be increased when it is combined with Promestriene.Investigational
Meclofenamic acidMeclofenamic acid may increase the thrombogenic activities of Promestriene.Approved, Vet Approved
MedrysoneThe serum concentration of Medrysone can be increased when it is combined with Promestriene.Approved
Mefenamic acidMefenamic acid may increase the thrombogenic activities of Promestriene.Approved
MelagatranPromestriene may decrease the anticoagulant activities of Melagatran.Experimental
MelengestrolThe serum concentration of Melengestrol can be increased when it is combined with Promestriene.Vet Approved
MeloxicamMeloxicam may increase the thrombogenic activities of Promestriene.Approved, Vet Approved
MesalazineMesalazine may increase the thrombogenic activities of Promestriene.Approved
MometasoneThe serum concentration of Mometasone can be increased when it is combined with Promestriene.Approved, Vet Approved
MorniflumateMorniflumate may increase the thrombogenic activities of Promestriene.Approved
NabumetoneNabumetone may increase the thrombogenic activities of Promestriene.Approved
NadroparinPromestriene may decrease the anticoagulant activities of Nadroparin.Approved, Investigational
NafamostatPromestriene may decrease the anticoagulant activities of Nafamostat.Approved, Investigational
NCX 1022The serum concentration of NCX 1022 can be increased when it is combined with Promestriene.Investigational
NepafenacNepafenac may increase the thrombogenic activities of Promestriene.Approved, Investigational
Niflumic AcidNiflumic Acid may increase the thrombogenic activities of Promestriene.Approved
NimesulideNimesulide may increase the thrombogenic activities of Promestriene.Approved, Investigational, Withdrawn
Oleoyl-estroneThe serum concentration of Oleoyl-estrone can be increased when it is combined with Promestriene.Investigational
OspemifeneThe risk or severity of adverse effects can be increased when Promestriene is combined with Ospemifene.Approved, Investigational
OtamixabanPromestriene may decrease the anticoagulant activities of Otamixaban.Investigational
OxaprozinOxaprozin may increase the thrombogenic activities of Promestriene.Approved
ParamethasoneThe serum concentration of Paramethasone can be increased when it is combined with Promestriene.Approved
ParecoxibParecoxib may increase the thrombogenic activities of Promestriene.Approved
Pentaerythritol TetranitratePromestriene may decrease the anticoagulant activities of Pentaerythritol Tetranitrate.Approved
Pentosan PolysulfatePromestriene may decrease the anticoagulant activities of Pentosan Polysulfate.Approved
PhenindionePromestriene may decrease the anticoagulant activities of Phenindione.Approved, Investigational
PhenprocoumonPromestriene may decrease the anticoagulant activities of Phenprocoumon.Approved, Investigational
PhenylbutazonePhenylbutazone may increase the thrombogenic activities of Promestriene.Approved, Vet Approved
PiroxicamPiroxicam may increase the thrombogenic activities of Promestriene.Approved, Investigational
PomalidomidePomalidomide may increase the thrombogenic activities of Promestriene.Approved
Potassium CitratePromestriene may decrease the anticoagulant activities of Potassium Citrate.Approved, Investigational, Vet Approved
PrasteroneThe risk or severity of adverse effects can be increased when Prasterone is combined with Promestriene.Approved, Investigational, Nutraceutical
Prasterone sulfateThe serum concentration of Prasterone sulfate can be increased when it is combined with Promestriene.Investigational
PrednicarbateThe serum concentration of Prednicarbate can be increased when it is combined with Promestriene.Approved, Investigational
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Promestriene.Approved, Vet Approved
PregnenoloneThe serum concentration of Pregnenolone can be increased when it is combined with Promestriene.Approved, Experimental, Investigational
Protein CPromestriene may decrease the anticoagulant activities of Protein C.Approved
Protein S humanPromestriene may decrease the anticoagulant activities of Protein S human.Approved
ProtocatechualdehydePromestriene may decrease the anticoagulant activities of Protocatechualdehyde.Approved
ResveratrolResveratrol may increase the thrombogenic activities of Promestriene.Approved, Experimental, Investigational
ReviparinPromestriene may decrease the anticoagulant activities of Reviparin.Approved, Investigational
RimexoloneThe serum concentration of Rimexolone can be increased when it is combined with Promestriene.Approved
RivaroxabanPromestriene may decrease the anticoagulant activities of Rivaroxaban.Approved
RofecoxibRofecoxib may increase the thrombogenic activities of Promestriene.Approved, Investigational, Withdrawn
RopinirolePromestriene may increase the excretion rate of Ropinirole which could result in a lower serum level and potentially a reduction in efficacy.Approved, Investigational
SalsalateSalsalate may increase the thrombogenic activities of Promestriene.Approved
SeliciclibSeliciclib may increase the thrombogenic activities of Promestriene.Investigational
Sodium CitratePromestriene may decrease the anticoagulant activities of Sodium Citrate.Approved, Investigational
SomatotropinThe therapeutic efficacy of Somatotropin can be decreased when used in combination with Promestriene.Approved, Investigational
SulodexidePromestriene may decrease the anticoagulant activities of Sulodexide.Approved, Investigational
SuprofenSuprofen may increase the thrombogenic activities of Promestriene.Approved, Withdrawn
TalniflumateTalniflumate may increase the thrombogenic activities of Promestriene.Approved
TenoxicamTenoxicam may increase the thrombogenic activities of Promestriene.Approved
ThalidomidePromestriene may increase the thrombogenic activities of Thalidomide.Approved, Investigational, Withdrawn
TheophyllineThe serum concentration of Theophylline can be increased when it is combined with Promestriene.Approved
Thyroid, porcineThe therapeutic efficacy of Thyroid, porcine can be decreased when used in combination with Promestriene.Approved
Tiaprofenic acidTiaprofenic acid may increase the thrombogenic activities of Promestriene.Approved
TipranavirPromestriene may increase the dermatologic adverse activities of Tipranavir.Approved, Investigational
TixocortolThe serum concentration of Tixocortol can be increased when it is combined with Promestriene.Approved, Withdrawn
TolmetinTolmetin may increase the thrombogenic activities of Promestriene.Approved
TriamcinoloneThe serum concentration of Triamcinolone can be increased when it is combined with Promestriene.Approved, Vet Approved
TroxerutinPromestriene may decrease the anticoagulant activities of Troxerutin.Investigational
UlobetasolThe serum concentration of Ulobetasol can be increased when it is combined with Promestriene.Approved
Ursodeoxycholic acidThe therapeutic efficacy of Ursodeoxycholic acid can be decreased when used in combination with Promestriene.Approved, Investigational
ValaciclovirThe serum concentration of Valaciclovir can be increased when it is combined with Promestriene.Approved, Investigational
ValdecoxibValdecoxib may increase the thrombogenic activities of Promestriene.Approved, Investigational, Withdrawn
WarfarinPromestriene may decrease the anticoagulant activities of Warfarin.Approved
XimelagatranPromestriene may decrease the anticoagulant activities of Ximelagatran.Approved, Investigational, Withdrawn
Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Substance
347911337
Wikipedia
Promestriene
ATC Codes
G03CA09 — Promestriene

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3CompletedPreventionHypospadias1
4CompletedSupportive CareAtrophic Vaginitis / Endometrial Hyperplasia / Pelvic Organ Prolapse (POP)1
4Not Yet RecruitingTreatmentVulvovaginal Atrophy1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on October 20, 2016 16:34 / Updated on August 02, 2018 06:39