Oxatomide

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Oxatomide
Accession Number
DB12877
Type
Small Molecule
Groups
Investigational
Description

Oxatomide has been used in trials studying the treatment of Muscular Dystrophy, Duchenne.

Structure
Thumb
Synonyms
Not Available
Categories
UNII
J31IL9Z2EE
CAS number
60607-34-3
Weight
Average: 426.564
Monoisotopic: 426.241961602
Chemical Formula
C27H30N4O
InChI Key
BAINIUMDFURPJM-UHFFFAOYSA-N
InChI
InChI=1S/C27H30N4O/c32-27-28-24-14-7-8-15-25(24)31(27)17-9-16-29-18-20-30(21-19-29)26(22-10-3-1-4-11-22)23-12-5-2-6-13-23/h1-8,10-15,26H,9,16-21H2,(H,28,32)
IUPAC Name
1-{3-[4-(diphenylmethyl)piperazin-1-yl]propyl}-2,3-dihydro-1H-1,3-benzodiazol-2-one
SMILES
OC1=NC2=CC=CC=C2N1CCCN1CCN(CC1)C(C1=CC=CC=C1)C1=CC=CC=C1

Pharmacology

Indication
Not Available
Structured Indications
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
PathwayCategory
Oxatomide H1-Antihistamine ActionDrug action
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
2,5-Dimethoxy-4-ethylamphetamine2,5-Dimethoxy-4-ethylamphetamine may decrease the sedative activities of Oxatomide.Experimental, Illicit
2,5-Dimethoxy-4-ethylthioamphetamine2,5-Dimethoxy-4-ethylthioamphetamine may decrease the sedative activities of Oxatomide.Experimental
3,4-Methylenedioxyamphetamine3,4-Methylenedioxyamphetamine may decrease the sedative activities of Oxatomide.Experimental, Illicit
4-Bromo-2,5-dimethoxyamphetamine4-Bromo-2,5-dimethoxyamphetamine may decrease the sedative activities of Oxatomide.Experimental, Illicit
AmphetamineAmphetamine may decrease the sedative activities of Oxatomide.Approved, Illicit, Investigational
BenzphetamineBenzphetamine may decrease the sedative activities of Oxatomide.Approved, Illicit
Benzylpenicilloyl PolylysineOxatomide may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.Approved
BetahistineThe therapeutic efficacy of Betahistine can be decreased when used in combination with Oxatomide.Approved, Investigational
ChlorphentermineChlorphentermine may decrease the sedative activities of Oxatomide.Illicit, Withdrawn
DextroamphetamineDextroamphetamine may decrease the sedative activities of Oxatomide.Approved, Illicit
DiethylpropionDiethylpropion may decrease the sedative activities of Oxatomide.Approved, Illicit
GepefrineGepefrine may decrease the sedative activities of Oxatomide.Experimental
HyaluronidaseThe therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Oxatomide.Approved, Investigational
HydroxyamphetamineHydroxyamphetamine may decrease the sedative activities of Oxatomide.Approved
Iofetamine I-123Iofetamine I-123 may decrease the sedative activities of Oxatomide.Approved
LisdexamfetamineLisdexamfetamine may decrease the sedative activities of Oxatomide.Approved, Investigational
MephedroneMephedrone may decrease the sedative activities of Oxatomide.Investigational
MephentermineMephentermine may decrease the sedative activities of Oxatomide.Approved
MethamphetamineMethamphetamine may decrease the sedative activities of Oxatomide.Approved, Illicit
MethoxyphenamineMethoxyphenamine may decrease the sedative activities of Oxatomide.Experimental
MidomafetamineMidomafetamine may decrease the sedative activities of Oxatomide.Experimental, Illicit, Investigational
MMDAMMDA may decrease the sedative activities of Oxatomide.Experimental, Illicit
PhenterminePhentermine may decrease the sedative activities of Oxatomide.Approved, Illicit
PseudoephedrinePseudoephedrine may decrease the sedative activities of Oxatomide.Approved
RitobegronRitobegron may decrease the sedative activities of Oxatomide.Investigational
Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Compound
4615
PubChem Substance
347829033
ChemSpider
4454
BindingDB
76863
ChEBI
31943
ChEMBL
CHEMBL13828
PharmGKB
PA163522137
ATC Codes
R06AE06 — Oxatomide

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2CompletedTreatmentMuscular Dystrophy, Duchenne1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0393 mg/mLALOGPS
logP4.71ALOGPS
logP4.62ChemAxon
logS-4ALOGPS
pKa (Strongest Acidic)12.92ChemAxon
pKa (Strongest Basic)8.01ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area38.82 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity130.94 m3·mol-1ChemAxon
Polarizability48.56 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Diphenylmethanes
Direct Parent
Diphenylmethanes
Alternative Parents
Benzimidazoles / N-alkylpiperazines / Aralkylamines / N-substituted imidazoles / Heteroaromatic compounds / Ureas / Trialkylamines / Azacyclic compounds / Organopnictogen compounds / Organooxygen compounds
show 2 more
Substituents
Diphenylmethane / Benzimidazole / N-alkylpiperazine / Aralkylamine / 1,4-diazinane / N-substituted imidazole / Piperazine / Azole / Imidazole / Heteroaromatic compound
show 14 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available

Drug created on October 20, 2016 18:57 / Updated on December 01, 2017 16:34