Pruritus

Also known as: Itch / Pruritus NOS / Itching / Pruritis / Unspecified pruritic disorder / Pruritus cutaneous / Itchy skin / Itchy

DrugDrug NameDrug Description
DB09488AcrivastineAcrivastine is a triprolidine analog antihistamine indicated for the treatment of allergies and hay fever. As an H1 receptor antagonist, it functions by blocking the action of histamine at this receptor thereby preventing the symptoms associated with histamine release such as pruritis, vasodilation, hypotension, edema, bronchoconstriction, and tachycardia. Acrivastine is currently available in combination with pseudoephedrine as the FDA-approved product Semprex-D.
DB14544Hydrocortisone valerateNot Available
DB00557HydroxyzineA histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite cetirizine, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative.
DB00455LoratadineLoratadine is a derivative of azatadine and a second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (histamine H1 antagonists) it lacks central nervous system depressing effects such as drowsiness.
DrugDrug NameTargetType
DB09488AcrivastineHistamine H1 receptortarget
DB14544Hydrocortisone valerateAnnexin A1target
DB14544Hydrocortisone valerateGlucocorticoid receptortarget
DB14544Hydrocortisone valerateSex hormone-binding globulincarrier
DB14544Hydrocortisone valerateCytochrome P450 3A4enzyme
DB14544Hydrocortisone valerateCytochrome P450 3A5enzyme
DB14544Hydrocortisone valerateCytochrome P450 3A7enzyme
DB14544Hydrocortisone valerateMultidrug resistance protein 1transporter
DB14544Hydrocortisone valerateSolute carrier organic anion transporter family member 1A2transporter
DB14544Hydrocortisone valerateATP-binding cassette sub-family G member 2transporter
DB14544Hydrocortisone valerateCytochrome P450 11B1, mitochondrialenzyme
DB14544Hydrocortisone valerateCytochrome P450 11B2, mitochondrialenzyme
DB14544Hydrocortisone valerateCytochrome P450 2C8enzyme
DB14544Hydrocortisone valerateCorticosteroid-binding globulincarrier
DB14544Hydrocortisone valerateCorticosteroid 11-beta-dehydrogenase isozyme 2target
DB14544Hydrocortisone valerate3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
DB14544Hydrocortisone valerateSolute carrier family 22 member 8transporter
DB00557HydroxyzineHistamine H1 receptortarget
DB00557HydroxyzineCytochrome P450 2D6enzyme
DB00455LoratadineHistamine H1 receptortarget
DB00455LoratadineCytochrome P450 3A4enzyme
DB00455LoratadineCytochrome P450 2C19enzyme
DB00455LoratadineCytochrome P450 2D6enzyme
DB00455LoratadineCytochrome P450 2C8enzyme
DB00455LoratadineMultidrug resistance protein 1transporter
DB00455LoratadinePotassium voltage-gated channel subfamily H member 2target
DB00455LoratadineBile salt export pumptransporter
DrugDrug NamePhaseStatusCount
DB00083Botulinum toxin type A1Active Not Recruiting1
DB00996Gabapentin1Withdrawn1
DB09153Sodium Chloride1Active Not Recruiting1
DB12580Tradipitant1Completed1
DB06774Capsaicin1 / 2Completed1
DB00321Amitriptyline2Terminated1
DB00673Aprepitant2Completed1
DB05104Asimadoline2Completed1
DB02300Calcipotriol2Active Not Recruiting1
DB11121Chloroxylenol2Unknown Status1
DB01003Cromoglicic acid2Completed1
DB11938Difelikefalin2Completed1
DB11938Difelikefalin2Recruiting1
DB01221Ketamine2Terminated1
DB00281Lidocaine2Terminated1
DB01183Naloxone2Completed1
DB12427Orvepitant2Withdrawn1
DB12973Serlopitant2Active Not Recruiting1
DB12973Serlopitant2Completed2
DB12973Serlopitant2Terminated1
DB01104Sertraline2Completed1
DB00193Tramadol2Unknown Status1
DB10579Wheat2Completed1
DB00295Morphine2 / 3Completed1
DB00844Nalbuphine2 / 3Completed3
DB01183Naloxone2 / 3Completed1
DB00996Gabapentin3Completed1
DB00295Morphine3Completed1
DB00497Oxycodone3Completed1
DB12973Serlopitant3Recruiting3
DB00673Aprepitant4Terminated1
DB00341Cetirizine4Terminated1
DB01234Dexamethasone4Completed1
DB00950Fexofenadine4Completed1
DB06717Fosaprepitant4Terminated1
DB00557Hydroxyzine4Completed1
DB06282Levocetirizine4Completed1
DB00295Morphine4Completed1
DB00904Ondansetron4Completed1
DB00904Ondansetron4Recruiting1
DB09153Sodium Chloride4Completed1
DB00518AlbendazoleNot AvailableCompleted1
DB06774CapsaicinNot AvailableRecruiting1
DB14184CinnamaldehydeNot AvailableRecruiting1
DB01234DexamethasoneNot AvailableCompleted1
DB00996GabapentinNot AvailableCompleted1
DB00996GabapentinNot AvailableUnknown Status1
DB00602IvermectinNot AvailableCompleted1
DB00825LevomentholNot AvailableRecruiting1
DB00455LoratadineNot AvailableCompleted1
DB00904OndansetronNot AvailableCompleted1
DB11365SennosidesNot AvailableCompleted1